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Ewa Malatynska

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Ewa Malatynska; Olga Redkozubova; Harry W M Steinbusch; Sergei Bachurin; Alexei Bolkunov; Aslan Kubatiev; Julie Vignisse; Naira B Yeritsyan; Tatyana Strekalova
Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression.
Yuval Feder; Elimelech Nesher; Ariel Ogran; Anatoly Kreinin; Ewa Malatynska; Gal Yadid; Albert Pinhasov
Selective breeding for dominant and submissive behavior in Sabra mice.
Michael H Parker; Virginia L Smith-Swintosky; David F McComsey; Yifang Huang; Douglas Brenneman; Brian Klein; Ewa Malatynska; H White; Michael E Milewski; Mark Herb; Michael F A Finley; Yi Liu; Mary Lou Lubin; Ning Qin; Robert Iannucci; Laurent Leclercq; Filip Cuyckens; Allen B Reitz; Bruce E Maryanoff
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

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All Publications

2012: Ewa Malatynska; Olga Redkozubova; Harry W M Steinbusch; Sergei Bachurin; Alexei Bolkunov; Aslan Kubatiev; Julie Vignisse; Naira B Yeritsyan; Tatyana Strekalova
Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression.
Experimental gerontology 2012;47(8):552-64.
2010: Yuval Feder; Elimelech Nesher; Ariel Ogran; Anatoly Kreinin; Ewa Malatynska; Gal Yadid; Albert Pinhasov
Selective breeding for dominant and submissive behavior in Sabra mice.
Journal of affective disorders 2010;126(1-2):214-22.
2009: Michael H Parker; Virginia L Smith-Swintosky; David F McComsey; Yifang Huang; Douglas Brenneman; Brian Klein; Ewa Malatynska; H White; Michael E Milewski; Mark Herb; Michael F A Finley; Yi Liu; Mary Lou Lubin; Ning Qin; Robert Iannucci; Laurent Leclercq; Filip Cuyckens; Allen B Reitz; Bruce E Maryanoff
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.
Journal of medicinal chemistry 2009;52(23):7528-36.
2007: Ewa Malatynska; Albert Pinhasov; Jeffrey J Crooke; Virginia L Smith-Swintosky; Douglas E Brenneman
Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: technical considerations.
Journal of neuroscience methods 2007;165(2):175-82.
2007: Ewa Malatynska; Albert Pinhasov; Christopher J Creighton; Jeffrey J Crooke; Allen B Reitz; Douglas E Brenneman; Mariusz S Lubomirski
Assessing activity onset time and efficacy for clinically effective antidepressant and antimanic drugs in animal models based on dominant-submissive relationships.
Neuroscience and biobehavioral reviews 2007;31(6):904-19.
2006: Ewa Malatynska; Albert Pinhasov; Jeffrey J Crooke; Daniel Horowitz; Douglas E Brenneman; Sergey E Ilyin
Levels of mRNA coding for alpha-, beta-, and gamma-synuclein in the brains of newborn, juvenile, and adult rats.
Journal of molecular neuroscience : MN 2006;29(3):269-77.
2005: Albert Pinhasov; Jeffrey J Crooke; Daniel Rosenthal; Douglas E Brenneman; Ewa Malatynska
Reduction of Submissive Behavior Model for antidepressant drug activity testing: study using a video-tracking system.
Behavioural pharmacology 2005;16(8):657-64.
2005: Ewa Malatynska; Robert Rapp; David Harrawood; Godfrey Tunnicliff
Submissive behavior in mice as a test for antidepressant drug activity.
Pharmacology, biochemistry, and behavior 2005;82(2):306-13.
2005: Gregory C Leo; Gary W Caldwell; Jeffrey J Crooke; Ewa Malatynska; Carlos Cotto; Becki Hastings; Jaclyn Scowcroft; Jeffrey Hall; Karina Browne; William Hageman
The application of nuclear magnetic resonance-based metabonomics to the dominant-submissive rat behavioral model.
Analytical biochemistry 2005;339(1):174-8.
2005: Albert Pinhasov; Sergey E Ilyin; Jeffrey J Crooke; Frank A Amato; Anil Vaidya; Daniel Rosenthal; Douglas E Brenneman; Ewa Malatynska
Different levels of gamma-synuclein mRNA in the cerebral cortex of dominant, neutral and submissive rats selected in the competition test.
Genes, brain, and behavior 2005;4(1):60-4.
2005: Ewa Malatynska; Richard J Knapp
Dominant-submissive behavior as models of mania and depression.
Neuroscience and biobehavioral reviews 2005;29(4-5):715-37.
2003: Godfrey Tunnicliff; Ewa Malatynska
Central GABAergic systems and depressive illness.
Neurochemical research 2003;28(6):965-76.
2002: Richard J Knapp; Rachel Goldenberg; Caroline Shuck; Alicia Cecil; Jeff Watkins; Cortland Miller; Glenda J. Crites; Ewa Malatynska
Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model.
European journal of pharmacology 2002;440(1):27-35.
2002: Ewa Malatynska; Rachel Goldenberg; Lucy Shuck; Arif Haque; Paula Zamecki; Glenda J. Crites; Nancy Schindler; Richard J Knapp
Reduction of submissive behavior in rats: a test for antidepressant drug activity.
Pharmacology 2002;64(1):8-17.
2001: Ewa Malatynska; Wanda Dyr; Pawel Krzascik; Wojciech Kostowski
Changes in ethanol preference by rats treated with gamma1 and gamma2 GABA(A) receptor subunit antisense oligodeoxynucleotides.
Alcohol and alcoholism (Oxford, Oxfordshire) 2001;36(4):309-13.
2000: Ewa Malatynska; Glenda J. Crites; David Harrawood; R Goldenberg; GK Matheson
Antidepressant effects on GABA-stimulated 36Cl(-) influx in rat cerebral cortex are altered after treatment with GABA(A) receptor antisense oligodeoxynucleotides.
Brain research 2000;869(1-2):78-84.
2000: Ewa Malatynska; GK Matheson; Rachel Goldenberg; Glenda J. Crites; Nancy Schindler; D Weinzapfel; David Harrawood; A Yochum; Godfrey Tunnicliff
Effects of treatment with GABA(A) receptor subunit antisense oligodeoxynucleotides on GABA-stimulated 36Cl- influx in the rat cerebral cortex.
Neurochemistry international 2000;36(1):45-54.
1999: Ewa Malatynska; C Miller; Nancy Schindler; A Cecil; A Knapp; Glenda J. Crites; H Rogers
Amitriptyline increases GABA-stimulated 36Cl- influx by recombinant (alpha 1 gamma 2) GABAA receptors.
Brain research 1999;851(1-2):277-80.
1999: Godfrey Tunnicliff; Nancy Schindler; Glenda J. Crites; Rachel Goldenberg; A Yochum; Ewa Malatynska
The GABA(A) receptor complex as a target for fluoxetine action.
Neurochemical research 1999;24(10):1271-6.
1999: H Bartosz-Bechowski; Peg Davis; J Slaninova; Ewa Malatynska; Dagmar Stropova; Frank Porreca; Henry I Yamamura; Victor J Hruby
Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors.
The journal of peptide research : official journal of the American Peptide Society 1999;53(3):329-36.
1998: Ewa Malatynska; Sue Waite; H B Wei; Richard J Knapp; Henry I Yamamura; William R Roeske
Structural correlates for down-regulation of m1 and m2 muscarinic receptor subtypes.
Brain research bulletin 1998;47(3):285-90.
1998: Ewa Malatynska; Glenda J. Crites; A Yochum; R Kopp; M L Giroux; S C Dilsaver
Schild regression analysis of antidepressant and bicuculline antagonist effects at the GABAA receptor.
Pharmacology 1998;57(3):117-23.
1996: E V Varga; X Li; Dagmar Stropova; T Zalewska; R S Landsman; Richard J Knapp; Ewa Malatynska; K Kawai; A Mizusura; Hiroshi Nagase; SN Calderon; K Rice; Victor J Hruby; William R Roeske; Henry I Yamamura
The third extracellular loop of the human delta-opioid receptor determines the selectivity of delta-opioid agonists.
Molecular pharmacology 1996;50(6):1619-24.
1996: Ewa Malatynska; Y Wang; Richard J Knapp; Sue Waite; SN Calderon; K Rice; Victor J Hruby; Henry I Yamamura; William R Roeske
Human delta opioid receptor: functional studies on stably transfected Chinese hamster ovary cells after acute and chronic treatment with the selective nonpeptidic agonist SNC-80.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1083-9.
1996: Richard J Knapp; G Santoro; I A De Leon; K B Lee; S A Edsall; Sue Waite; Ewa Malatynska; E Varga; SN Calderon; Kenner C Rice; Richard B Rothman; F Porreca; William R Roeske; Henry I Yamamura
Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1284-91.
1996: X Li; E V Varga; Dagmar Stropova; T Zalewska; Ewa Malatynska; Richard J Knapp; William R Roeske; Henry I Yamamura
delta-Opioid receptor: the third extracellular loop determines naltrindole selectivity.
European journal of pharmacology 1996;300(1-2):R1-2.
1995: Richard J Knapp; R Landsman; Sue Waite; Ewa Malatynska; E Varga; W Haq; Victor J Hruby; William R Roeske; Hiroshi Nagase; Henry I Yamamura
Properties of TAN-67, a nonpeptidic delta-opioid receptor agonist, at cloned human delta- and mu-opioid receptors.
European journal of pharmacology 1995;291(2):129-34.
1995: Ewa Malatynska; Richard J Knapp; Dagmar Stropova; E Varga; Henry I Yamamura
The role of the Val353 residue in antagonist binding to rat CCK-B receptors.
Neuroreport 1995;6(9):1325-9.
1995: Richard J Knapp; Ewa Malatynska; N Collins; L Fang; J Y Wang; Victor J Hruby; William R Roeske; Henry I Yamamura
Molecular biology and pharmacology of cloned opioid receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(7):516-25.
1995: Ewa Malatynska; Y Wang; Richard J Knapp; G Santoro; X Li; Sue Waite; William R Roeske; Henry I Yamamura
Human delta opioid receptor: a stable cell line for functional studies of opioids.
Neuroreport 1995;6(4):613-6.
1995: Ewa Malatynska; I De Leon; D Allen; Henry I Yamamura
Effects of amitriptyline on GABA-stimulated 36CI- uptake in relation to a behavioral model of depression.
Brain research bulletin 1995;37(1):53-9.
1995: Richard J Knapp; Sue Waite; R Landsman; G Santoro; I A De Leon; Ewa Malatynska; E Varga; Hiroshi Nagase; SN Calderon; K Rice
Efficacy of peptide and nonpeptidic agonists at the cloned human delta opioid receptor.
Proceedings of the Western Pharmacology Society 1995;38():141-3.
1994: Richard J Knapp; Ewa Malatynska; P Peterson; T Zalewska; S Fang; Victor J Hruby; T L Smith; Henry I Yamamura
[N-methylnorleucine-(28,31)]cholecystokinin-(26-33) (SNF 8702) activity at a cloned rat CCKB receptor.
European journal of pharmacology 1994;269(2):133-8.
1994: Richard J Knapp; Ewa Malatynska; S Hashimoto; S Fang; M Hunt; J K Wamsley; P Peterson; T Zalewska; Victor J Hruby; Henry I Yamamura
[3H]SNF8702 autoradiography of CCK-B receptors in guinea pig brain and studies with a cloned rat CCK-B receptor.
Annals of the New York Academy of Sciences 1994;713():380-3.
1994: Richard J Knapp; Ewa Malatynska; L Fang; X Li; E Babin; M Nguyen; G Santoro; E V Varga; Victor J Hruby; William R Roeske
Identification of a human delta opioid receptor: cloning and expression.
Life sciences 1994;54(25):PL463-9.
1993: P J Horan; A Mattia; E J Bilsky; S Weber; Thomas P Davis; Henry I Yamamura; Ewa Malatynska; Suzanne M Appleyard; J Slaninova; Aleksandra Misicka
Antinociceptive profile of biphalin, a dimeric enkephalin analog.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1446-54.
1992: Ewa Malatynska; M L Giroux; Steven C Dilsaver; S B Schwarzkopf
Bidirectional effect of beta-carboline agonists at the benzodiazepine-GABAA receptor chloride ionophore complex on GABA-stimulated 36Cl- uptake.
Brain research bulletin 1992;28(4):605-11.
1992: M S Yamamura; R Horvath; G Toth; F Otvos; Ewa Malatynska; Richard J Knapp; F Porreca; Victor J Hruby; Henry I Yamamura
Characterization of [3H]naltrindole binding to delta opioid receptors in rat brain.
Life sciences 1992;50(16):PL119-24.
1991: Ewa Malatynska; M L Giroux; Steven C Dilsaver; S B Schwarzkopf
Chronic treatment with amitriptyline alters the GABA-mediated uptake of 36Cl- in the rat brain.
Pharmacology, biochemistry, and behavior 1991;39(2):553-6.
1991: M L Giroux; Ewa Malatynska; Steven C Dilsaver
Bright light does not alter muscarinic receptor binding parameters.
Pharmacology, biochemistry, and behavior 1991;38(3):695-7.
1991: Ewa Malatynska; S C Dilsaver; R J Knapp; M L Giroux; M Ikeda; Henry I Yamamura
The interaction of a benzodiazepine receptor antagonist (Ro15-1788) with GABA and GABA receptor antagonists at the GABA(A) receptor chloride-ionophore complex.
Neurochemistry international 1991;18(3):405-10.
1990: Richard J Knapp; Ewa Malatynska; Henry I Yamamura
From binding studies to the molecular biology of GABA receptors.
Neurochemical research 1990;15(2):105-12.
1989: Ewa Malatynska; R Knapp; M Ikeda; Henry I Yamamura
Beta-carboline interactions at the BZ-GABA receptor chloride-ionophore complex in the rat cerebral cortex.
Brain research bulletin 1989;22(5):845-8.
1989: M Ikeda; K H Weber; W D Bechtel; Ewa Malatynska; Henry I Yamamura
Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles.
Life sciences 1989;45(4):349-58.
1989: M Ikeda; Richard J Knapp; Ewa Malatynska; Henry I Yamamura
Amoxapine inhibition of GABA-stimulated chloride conductance: investigations of potential sites of activity.
Life sciences 1989;45(20):1903-10.
1988: Ewa Malatynska; M Serra; M Ikeda; G Biggio; Henry I Yamamura
Modulation of GABA-stimulated chloride influx by beta-carbolines in rat brain membrane vesicles.
Brain research 1988;443(1-2):395-7.
1988: T Obata; Henry I Yamamura; Ewa Malatynska; M Ikeda; H Laird; C J Palmer; J E Casida
Modulation of gamma-aminobutyric acid-stimulated chloride influx by bicycloorthocarboxylates, bicyclophosphorus esters, polychlorocycloalkanes and other cage convulsants.
The Journal of pharmacology and experimental therapeutics 1988;244(3):802-6.
1988: Ewa Malatynska; Richard J Knapp; M Ikeda; Henry I Yamamura
Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex.
Life sciences 1988;43(4):303-7.