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Harry Malech
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41
Gallin, John
24
Holland, Steven
20
Linton, Gilda
19
Leto, Thomas
16
Whiting-Theobald, Narda
11
Horwitz, Mitchell
11
Choi, Uimook
10
Brenner, Sebastian
10
Leitman, Susan
9
Fleisher, Thomas
8
Anderson, Victoria
8
Puck, Jennifer
7
Barrett, John
6
Brown, Margaret
6
Bodine, David
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All Publications
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2009: Larochelle Andre; Choi Uimook; Shou Yan; Naumann Nora; Loktionova Natalia A; Clevenger Joshua R; Krouse Allen; Metzger Mark; Donahue Robert E; Kang Elizabeth; Stewart Clinton; Persons Derek; Malech Harry L; Dunbar Cynthia E; Sorrentino Brian P
In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
The Journal of clinical investigation 2009;119(7):1952-63.
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2009: Friend Julia C; Hilligoss Dianne M; Marquesen Martha; Ulrick Jean; Estwick Tyra; Turner Maria L; Cowen Edward W; Anderson Victoria; Holland Steven M; Malech Harry L
Skin ulcers and disseminated abscesses are characteristic of Serratia marcescens infection in older patients with chronic granulomatous disease.
The Journal of allergy and clinical immunology 2009;124(1):164-6.
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2009: Sweeney Colin L; Malech Harry L
Functional neutrophils from human ES cells.
Blood 2009;113(26):6503-5.
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2009: Vinh Donald C; Freeman Alexandra F; Shea Yvonne R; Malech Harry L; Abinun Mario; Weinberg Geoffrey A; Holland Steven M
Mucormycosis in chronic granulomatous disease: association with iatrogenic immunosuppression.
The Journal of allergy and clinical immunology 2009;123(6):1411-3.
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2009: Throm Robert E; Ouma Annastasia A; Zhou Sheng; Chandrasekaran Anantharaman; Lockey Timothy; Greene Michael; De Ravin Suk See; Moayeri Morvarid; Malech Harry L; Sorrentino Brian P; Gray John T
Efficient construction of producer cell lines for a SIN lentiviral vector for SCID-X1 gene therapy by concatemeric array transfection.
Blood 2009;113(21):5104-10.
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2009: Kawai Toshinao; Malech Harry L
WHIM syndrome: congenital immune deficiency disease.
Current opinion in hematology 2009;16(1):20-6.
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2009: De Ravin Suk See; Malech Harry L
Partially corrected X-linked severe combined immunodeficiency: long-term problems and treatment options.
Immunologic research 2009;43(1-3):223-42.
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2009: Kang Elizabeth M; Malech Harry L
Advances in treatment for chronic granulomatous disease.
Immunologic research 2009;43(1-3):77-84.
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2008: Patel Asha R; Avila Daniele; Malech Harry L; Pavletic Steven Z; Yao Larry; Cowen Edward W
Rippled skin, fasciitis, and joint contractures.
Journal of the American Academy of Dermatology 2008;59(6):1070-4.
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2008: De Ravin Suk See; Shum Elaine; Zarember Kol A; Rezvani Geoffrey; Rosenfeld Ron G; Stratakis Constantine A; Malech Harry L
Short stature in partially corrected X-linked severe combined immunodeficiency--suboptimal response to growth hormone.
Journal of pediatric endocrinology & metabolism : JPEM 2008;21(11):1057-63.
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2008: Vasu Sumithira; Leitman Susan F; Tisdale John F; Hsieh Matthew M; Childs Richard W; Barrett A John; Fowler Daniel H; Bishop Michael R; Kang Elizabeth M; Malech Harry L; Dunbar Cynthia E; Khuu Hanh M; Wesley Robert; Yau Yu Y; Bolan Charles D
Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population.
Blood 2008;112(5):2092-100.
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2008: Feld Jordan J; Hussain Nadeem; Wright Elizabeth C; Kleiner David E; Hoofnagle Jay H; Ahlawat Sushil; Anderson Victoria; Hilligoss Dianne; Gallin John I; Liang T Jake; Malech Harry L; Holland Steven M; Heller Theo
Hepatic involvement and portal hypertension predict mortality in chronic granulomatous disease.
Gastroenterology 2008;134(7):1917-26.
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2007: Shearer William T; Malech Harry L; Puck Jennifer M
Primary immunodeficiency: meeting the challenges.
The Journal of allergy and clinical immunology 2007;120(4):753-5.
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2007: Holland Steven M; DeLeo Frank R; Elloumi Houda Z; Hsu Amy P; Uzel Gulbu; Brodsky Nina; Freeman Alexandra F; Demidowich Andrew; Davis Joie; Turner Maria L; Anderson Victoria L; Darnell Dirk N; Welch Pamela A; Kuhns Douglas B; Frucht David M; Malech Harry L; Gallin John I; Kobayashi Scott D; Whitney Adeline R; Voyich Jovanka M; Musser James M; Woellner Cristina; Schäffer Alejandro A; Puck Jennifer M; Grimbacher Bodo
STAT3 mutations in the hyper-IgE syndrome.
The New England journal of medicine 2007;357(16):1608-19.
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2007: Siddiqui Sophia; Anderson Victoria L; Hilligoss Diane M; Abinun Mario; Kuijpers Taco W; Masur Henry; Witebsky Frank G; Shea Yvonne R; Gallin John I; Malech Henry L; Holland Steven M
Fulminant mulch pneumonitis: an emergency presentation of chronic granulomatous disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;45(6):673-81.
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2007: Brenner Sebastian; Ryser Martin F; Whiting-Theobald Narda L; Gentsch Marcus; Linton Gilda F; Malech Harry L
The late dividing population of gamma-retroviral vector transduced human mobilized peripheral blood progenitor cells contributes most to gene-marked cell engraftment in nonobese diabetic/severe combined immunodeficient mice.
Stem cells (Dayton, Ohio) 2007;25(7):1807-13.
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2007: Chinen Javier; Davis Joie; De Ravin Suk See; Hay Beverly N; Hsu Amy P; Linton Gilda F; Naumann Nora; Nomicos Effie Y H; Silvin Christopher; Ulrick Jean; Whiting-Theobald Narda L; Malech Harry L; Puck Jennifer M
Gene therapy improves immune function in preadolescents with X-linked severe combined immunodeficiency.
Blood 2007;110(1):67-73.
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2007: Kawai Toshinao; Choi Uimook; Liu Po-Ching; Whiting-Theobald Narda L; Linton Gilda F; Malech Harry L
Diprotin A infusion into nonobese diabetic/severe combined immunodeficiency mice markedly enhances engraftment of human mobilized CD34+ peripheral blood cells.
Stem cells and development 2007;16(3):361-70.
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2007: Hussain Nadeem; Feld Jordan J; Kleiner David E; Hoofnagle Jay H; Garcia-Eulate Reyes; Ahlawat Sushil; Koziel Deloris E; Anderson Victoria; Hilligoss Dianne; Choyke Peter; Gallin John I; Liang T Jake; Malech Harry L; Holland Steven M; Heller Theo
Hepatic abnormalities in patients with chronic granulomatous disease.
Hepatology (Baltimore, Md.) 2007;45(3):675-83.
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2007: Malech Harry L; Hickstein Dennis D
Genetics, biology and clinical management of myeloid cell primary immune deficiencies: chronic granulomatous disease and leukocyte adhesion deficiency.
Current opinion in hematology 2007;14(1):29-36.
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2007: Kawai Toshinao; Choi Uimook; Cardwell Lanise; DeRavin Suk See; Naumann Nora; Whiting-Theobald Narda L; Linton Gilda F; Moon Jaehyun; Murphy Philip M; Malech Harry L
WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4.
Blood 2007;109(1):78-84.
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2007: Leto Thomas L; Lavigne Mark C; Homoyounpour Neda; Lekstrom Kristen; Linton Gilda; Malech Harry L; de Mendez Isabelle
The K-562 cell model for analysis of neutrophil NADPH oxidase function.
Methods in molecular biology (Clifton, N.J.) 2007;412():365-83.
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2007: Malech Harry L
The role of neutrophils in the immune system: an overview.
Methods in molecular biology (Clifton, N.J.) 2007;412():3-11.
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2006: Taylor Ross M; Baniulis Danas; Burritt James B; Gripentrog Jeannie M; Lord Connie I; Riesselman Marcia H; Maaty Walid S; Bothner Brian P; Angel Thomas E; Dratz Edward A; Linton Gilda F; Malech Harry L; Jesaitis Algirdas J
Analysis of human phagocyte flavocytochrome b(558) by mass spectrometry.
The Journal of biological chemistry 2006;281(48):37045-56.
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2006: Garcia-Eulate Reyes; Hussain Nadeem; Heller Theo; Kleiner David; Malech Harry; Holland Steven; Choyke Peter L
CT and MRI of hepatic abscess in patients with chronic granulomatous disease.
AJR. American journal of roentgenology 2006;187(2):482-90.
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2006: Brenner Sebastian; Ryser Martin F; Choi Uimook; Whiting-Theobald Narda; Kuhlisch Eberhard; Linton Gilda; Kang Elizabeth; Lehmann Romy; Rosen-Wolff Angela; Rudikoff Andrew G; Farese Ann M; Macvittie Thomas J; Roesler Joachim; Horwitz Mitchell E; Malech Harry L
Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(2):202-11.
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2006: Bleesing Jack J; Souto-Carneiro Margarida M; Savage William J; Brown Margaret R; Martinez Cynthia; Yavuz Sule; Brenner Sebastian; Siegel Richard M; Horwitz Mitchell E; Lipsky Peter E; Malech Harry L; Fleisher Thomas A
Patients with chronic granulomatous disease have a reduced peripheral blood memory B cell compartment.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):7096-103.
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2006: Puck Jennifer M; Malech Harry L
Gene therapy for immune disorders: good news tempered by bad news.
The Journal of allergy and clinical immunology 2006;117(4):865-9.
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2006: Ting-De Ravin Suk See; Kennedy Douglas R; Naumann Nora; Kennedy Jeffrey S; Choi Uimook; Hartnett Brian J; Linton Gilda F; Whiting-Theobald Narda L; Moore Peter F; Vernau William; Malech Harry L; Felsburg Peter J
Correction of canine X-linked severe combined immunodeficiency by in vivo retroviral gene therapy.
Blood 2006;107(8):3091-7.
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2006: De Ravin Suk See; Naumann Nora; Robinson Michael R; Barron Karyl S; Kleiner David E; Ulrick Jean; Friend Julia; Anderson Victoria L; Darnell Dirk; Kang Elizabeth M; Malech Harry L
Sarcoidosis in chronic granulomatous disease.
Pediatrics 2006;117(3):e590-5.
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2006: Yamashita Kouhei; Horwitz Mitchell E; Kwatemaa Akua; Nomicos Effie; Castro Kathleen; Sokolic Robert; Foster Susan F; Garofalo Mary; Choi Uimook; Ryherd Mark; Brown Margaret R; Leitman Susan F; Wayne Alan S; Fowler Daniel H; Bishop Michael R; Childs Richard W; Barrett A John; Pavletic Steven Z; Malech Harry L
Unique abnormalities of CD4(+) and CD8(+) central memory cells associated with chronic graft-versus-host disease improve after extracorporeal photopheresis.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(1 Suppl 2):22-30.
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2005: Zarember Kol A; Malech Harry L
HIF-1alpha: a master regulator of innate host defenses?
The Journal of clinical investigation 2005;115(7):1702-4.
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2005: Lucas M Lee; Seidel Nancy E; Porada Christopher D; Quigley John G; Anderson Stacie M; Malech Harry L; Abkowitz Janis L; Zanjani Esmail D; Bodine David M
Improved transduction of human sheep repopulating cells by retrovirus vectors pseudotyped with feline leukemia virus type C or RD114 envelopes.
Blood 2005;106(1):51-8.
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2005: Segal Brahm H; Barnhart Lisa A; Anderson Victoria L; Walsh Thomas J; Malech Harry L; Holland Steven M
Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;40(11):1684-8.
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2005: Kawai Toshinao; Choi Uimook; Whiting-Theobald Narda L; Linton Gilda F; Brenner Sebastian; Sechler Joan M G; Murphy Philip M; Malech Harry L
Enhanced function with decreased internalization of carboxy-terminus truncated CXCR4 responsible for WHIM syndrome.
Experimental hematology 2005;33(4):460-8.
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2005: Ueda Takahiro; Brenner Sebastian; Malech Harry L; Langemeijer Saskia M; Perl Shira; Kirby Martha; Phang Oswald A; Krouse Allen E; Donahue Robert E; Kang Elizabeth M; Tisdale John F
Cloning and functional analysis of the rhesus macaque ABCG2 gene. Forced expression confers an SP phenotype among hematopoietic stem cell progeny in vivo.
The Journal of biological chemistry 2005;280(2):991-8.
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2004: Malech Harry L; Choi Uimook; Brenner Sebastian
Progress toward effective gene therapy for chronic granulomatous disease.
Japanese journal of infectious diseases 2004;57(5):S27-8.
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2004: Marciano Beatriz E; Wesley Robert; De Carlo Ellen S; Anderson Victoria L; Barnhart Lisa A; Darnell Dirk; Malech Harry L; Gallin John I; Holland Steven M
Long-term interferon-gamma therapy for patients with chronic granulomatous disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;39(5):692-9.
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2004: Choi Uimook; DeRavin Suk See; Yamashita Kouhei; Whiting-Theobald Narda; Linton Gilda F; Loktionova Natalia A; Pegg Anthony E; Malech Harry L
Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker.
Experimental hematology 2004;32(8):709-19.
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2004: Marciano Beatriz E; Rosenzweig Sergio D; Kleiner David E; Anderson Victoria L; Darnell Dirk N; Anaya-O'Brien Sandra; Hilligoss Dianne M; Malech Harry L; Gallin John I; Holland Steven M
Gastrointestinal involvement in chronic granulomatous disease.
Pediatrics 2004;114(2):462-8.
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2004: Pao Maryland; Wiggs Edythe A; Anastacio Melissa M; Hyun Jenny; DeCarlo Ellen S; Miller Judi T; Anderson Victoria L; Malech Harry L; Gallin John I; Holland Steven M
Cognitive function in patients with chronic granulomatous disease: a preliminary report.
Psychosomatics 2004;45(3):230-4.
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2004: Yamashita Kouhei; Choi Uimook; Woltz Patricia C; Foster Susan F; Sneller Michael C; Hakim Francis T; Fowler Daniel H; Bishop Michael R; Pavletic Steven Z; Tamari Marisa; Castro Kathleen; Barrett A John; Childs Richard W; Illei Gabor G; Leitman Susan F; Malech Harry L; Horwitz Mitchell E
Severe chronic graft-versus-host disease is characterized by a preponderance of CD4(+) effector memory cells relative to central memory cells.
Blood 2004;103(10):3986-8.
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2004: Bolan Charles D; Yau Yu Ying; Cullis Herbert C; Horwitz Mitchell E; Mackall Crystal L; Barrett A John; Malech Harry L; Rehak Nadja N; Wayne Alan S; Leitman Susan F
Pediatric large-volume leukapheresis: a single institution experience with heparin versus citrate-based anticoagulant regimens.
Transfusion 2004;44(2):229-38.
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2004: Kobayashi Scott D; Voyich Jovanka M; Braughton Kevin R; Whitney Adeline R; Nauseef William M; Malech Harry L; DeLeo Frank R
Gene expression profiling provides insight into the pathophysiology of chronic granulomatous disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):636-43.
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2004: Brenner Sebastian; Whiting-Theobald Narda; Kawai Toshinao; Linton Gilda F; Rudikoff Andrew G; Choi Uimook; Ryser Martin F; Murphy Philip M; Sechler Joan M G; Malech Harry L
CXCR4-transgene expression significantly improves marrow engraftment of cultured hematopoietic stem cells.
Stem cells (Dayton, Ohio) 2004;22(7):1128-33.
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2003: Anderson-Cohen Mindy; Holland Steve M; Kuhns Doug B; Fleisher Thomas A; Ding Li; Brenner Sebastian; Malech Harry L; Roesler Joachim
Severe phenotype of chronic granulomatous disease presenting in a female with a de novo mutation in gp91-phox and a non familial, extremely skewed X chromosome inactivation.
Clinical immunology (Orlando, Fla.) 2003;109(3):308-17.
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2003: Brenner Sebastian; Whiting-Theobald Narda L; Linton Gilda F; Holmes Kevin L; Anderson-Cohen Mindy; Kelly Patrick F; Vanin Elio F; Pilon André M; Bodine David M; Horwitz Mitchell E; Malech Harry L
Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells.
Blood 2003;102(8):2789-97.
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2003: Horwitz Mitchell E; Uzel Gulbu; Linton Gilda F; Miller Judi A; Brown Margaret R; Malech Harry L; Holland Steven M
Persistent Mycobacterium avium infection following nonmyeloablative allogeneic peripheral blood stem cell transplantation for interferon-gamma receptor-1 deficiency.
Blood 2003;102(7):2692-4.
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2003: Kohn Donald B; Sadelain Michel; Dunbar Cynthia; Bodine David; Kiem Hans-Peter; Candotti Fabio; Tisdale John; Riviére Isabelle; Blau C Anthony; Richard Robert E; Sorrentino Brian; Nolta Jan; Malech Harry; Brenner Malcolm; Cornetta Kenneth; Cavagnaro Joy; High Katherine; Glorioso Joseph;
American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(2):180-7.
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2003: Geiszt Miklós; Lekstrom Kristen; Brenner Sebastian; Hewitt Stephen M; Dana Raya; Malech Harry L; Leto Thomas L
NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):299-306.
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2003: Gallin John I; Alling David W; Malech Harry L; Wesley Robert; Koziol Deloris; Marciano Beatriz; Eisenstein Eli M; Turner Maria L; DeCarlo Ellen S; Starling Judith M; Holland Steven M
Itraconazole to prevent fungal infections in chronic granulomatous disease.
The New England journal of medicine 2003;348(24):2416-22.
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2003: Sugimoto Yoshikazu; Tsukahara Satomi; Sato Shigeo; Suzuki Mutsumi; Nunoi Hiroyuki; Malech Harry L; Gottesman Michael M; Tsuruo Takashi
Drug-selected co-expression of P-glycoprotein and gp91 in vivo from an MDR1-bicistronic retrovirus vector Ha-MDR-IRES-gp91.
The journal of gene medicine 2003;5(5):366-76.
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2003: Brenner Sebastian; Malech Harry L
Current developments in the design of onco-retrovirus and lentivirus vector systems for hematopoietic cell gene therapy.
Biochimica et biophysica acta 2003;1640(1):1-24.
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2003: Guide Shireen V; Stock Frida; Gill Vee J; Anderson Victoria L; Malech Harry L; Gallin John I; Holland Steven M
Reinfection, rather than persistent infection, in patients with chronic granulomatous disease.
The Journal of infectious diseases 2003;187(5):845-53.
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2003: Jirapongsananuruk Orathai; Malech Harry L; Kuhns Douglas B; Niemela Julie E; Brown Margaret R; Anderson-Cohen Mindy; Fleisher Thomas A
Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay.
The Journal of allergy and clinical immunology 2003;111(2):374-9.
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2003: Kobayashi Scott D; Voyich Jovanka M; Somerville Greg A; Braughton Kevin R; Malech Harry L; Musser James M; DeLeo Frank R
An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation.
Journal of leukocyte biology 2003;73(2):315-22.
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2002: Roesler Joachim; Brenner Sebastian; Bukovsky Anatoly A; Whiting-Theobald Narda; Dull Thomas; Kelly Michael; Civin Curt I; Malech Harry L
Third-generation, self-inactivating gp91(phox) lentivector corrects the oxidase defect in NOD/SCID mouse-repopulating peripheral blood-mobilized CD34+ cells from patients with X-linked chronic granulomatous disease.
Blood 2002;100(13):4381-90.
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2002: Kang Elizabeth M; De Witte Moniek; Malech Harry; Morgan Richard A; Carter Charles; Leitman Susan F; Childs Richard; Barrett A John; Little Richard; Tisdale John F
Gene therapy-based treatment for HIV-positive patients with malignancies.
Journal of hematotherapy & stem cell research 2002;11(5):809-16.
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2002: Dorman Susan E; Guide Shireen V; Conville Patricia S; DeCarlo Ellen S; Malech Harry L; Gallin John I; Witebsky Frank G; Holland Steven M
Nocardia infection in chronic granulomatous disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2002;35(4):390-4.
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2002: Jirapongsananuruk Orathai; Niemela Julie E; Malech Harry L; Fleisher Thomas A
CYBB mutation analysis in X-linked chronic granulomatous disease.
Clinical immunology (Orlando, Fla.) 2002;104(1):73-6.
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2002: Tsai Emily J; Malech Harry L; Kirby Martha R; Hsu Amy P; Seidel Nancy E; Porada Christopher D; Zanjani Esmail D; Bodine David M; Puck Jennifer M
Retroviral transduction of IL2RG into CD34(+) cells from X-linked severe combined immunodeficiency patients permits human T- and B-cell development in sheep chimeras.
Blood 2002;100(1):72-9.
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2002: Jackson Sharon H; Alicea Candido; Owens Jennie W; Eigsti Calvin L; Malech Harry L
Characterization of an early dendritic cell precursor derived from murine lineage-negative hematopoietic progenitor cells.
Experimental hematology 2002;30(5):430-9.
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2002: Lublin Matthew; Bartlett David L; Danforth David N; Kauffman Howard; Gallin John I; Malech Harry L; Shawker Thomas; Choyke Peter; Kleiner David E; Schwartzentruber Douglas J; Chang Richard; DeCarlo Ellen S; Holland Steven M
Hepatic abscess in patients with chronic granulomatous disease.
Annals of surgery 2002;235(3):383-91.
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2002: Kang Elizabeth M; de Witte Moniek; Malech Harry; Morgan Richard A; Phang Sheila; Carter Charles; Leitman Susan F; Childs Richard; Barrett A John; Little Richard; Tisdale John F
Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome.
Blood 2002;99(2):698-701.
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2001: Savage W J; Bleesing J J; Douek D; Brown M R; Linton G M; Malech H L; Horwitz M E
Lymphocyte reconstitution following non-myeloablative hematopoietic stem cell transplantation follows two patterns depending on age and donor/recipient chimerism.
Bone marrow transplantation 2001;28(5):463-71.
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2001: Pessach I; Leto T L; Malech H L; Levy R
Essential requirement of cytosolic phospholipase A(2) for stimulation of NADPH oxidase-associated diaphorase activity in granulocyte-like cells.
The Journal of biological chemistry 2001;276(36):33495-503.
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2001: Lavigne M C; Malech H L; Holland S M; Leto T L
Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.
Circulation 2001;104(1):79-84.
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2001: Avilés Mendoza G J; Seidel N E; Otsu M; Anderson S M; Simon-Stoos K; Herrera A; Hoogstraten-Miller S; Malech H L; Candotti F; Puck J M; Bodine D M
Comparison of five retrovirus vectors containing the human IL-2 receptor gamma chain gene for their ability to restore T and B lymphocytes in the X-linked severe combined immunodeficiency mouse model.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(4):565-73.
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2001: Horwitz M E; Barrett A J; Brown M R; Carter C S; Childs R; Gallin J I; Holland S M; Linton G F; Miller J A; Leitman S F; Read E J; Malech H L
Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft.
The New England journal of medicine 2001;344(12):881-8.
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2001: Vázquez N; Lehrnbecher T; Chen R; Christensen B L; Gallin J I; Malech H; Holland S; Zhu S; Chanock S J
Mutational analysis of patients with p47-phox-deficient chronic granulomatous disease: The significance of recombination events between the p47-phox gene (NCF1) and its highly homologous pseudogenes.
Experimental hematology 2001;29(2):234-43.
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2001: Stroncek D F; Procter J L; Moses L; Bolan C; Pomper G J; Conroy-Cantilena C; Malech H L; Klein H G; Leitman S F
Intravenous Rh immune globulin prevents alloimmunization in D- granulocyte recipients but obscures the detection of an allo-anti-K.
Immunohematology / American Red Cross 2001;17(2):37-41.
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2000: Uzel G; Premkumar A; Malech H L; Holland S M
Respiratory syncytial virus infection in patients with phagocyte defects.
Pediatrics 2000;106(4):835-7.
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2000: Segal B H; Leto T L; Gallin J I; Malech H L; Holland S M
Genetic, biochemical, and clinical features of chronic granulomatous disease.
Medicine 2000;79(3):170-200.
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2000: Centola M; Wood G; Frucht D M; Galon J; Aringer M; Farrell C; Kingma D W; Horwitz M E; Mansfield E; Holland S M; O'Shea J J; Rosenberg H F; Malech H L; Kastner D L
The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators.
Blood 2000;95(10):3223-31.
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1999: Rosenzweig M; MacVittie T J; Harper D; Hempel D; Glickman R L; Johnson R P; Farese A M; Whiting-Theobald N; Linton G F; Yamasaki G; Jordan C T; Malech H L
Efficient and durable gene marking of hematopoietic progenitor cells in nonhuman primates after nonablative conditioning.
Blood 1999;94(7):2271-86.
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1999: Grimbacher B; Schäffer A A; Holland S M; Davis J; Gallin J I; Malech H L; Atkinson T P; Belohradsky B H; Buckley R H; Cossu F; Español T; Garty B Z; Matamoros N; Myers L A; Nelson R P; Ochs H D; Renner E D; Wellinghausen N; Puck J M
Genetic linkage of hyper-IgE syndrome to chromosome 4.
American journal of human genetics 1999;65(3):735-44.
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1999: Horwitz M E; Malech H L; Anderson S M; Girard L J; Bodine D M; Orlic D
Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G1 of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA.
Experimental hematology 1999;27(7):1160-7.
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1999: Malech H L
Progress in gene therapy for chronic granulomatous disease.
The Journal of infectious diseases 1999;179 Suppl 2():S318-25.
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1999: Grimbacher B; Holland S M; Gallin J I; Greenberg F; Hill S C; Malech H L; Miller J A; O'Connell A C; Puck J M
Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder.
The New England journal of medicine 1999;340(9):692-702.
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1998: Segal B H; DeCarlo E S; Kwon-Chung K J; Malech H L; Gallin J I; Holland S M
Aspergillus nidulans infection in chronic granulomatous disease.
Medicine 1998;77(5):345-54.
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1998: Dana R; Leto T L; Malech H L; Levy R
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
The Journal of biological chemistry 1998;273(1):441-5.
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1997: Malech H L; Bauer T R; Hickstein D D
Prospects for gene therapy of neutrophil defects.
Seminars in hematology 1997;34(4):355-61.
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1997: Malech H L; Nauseef W M
Primary inherited defects in neutrophil function: etiology and treatment.
Seminars in hematology 1997;34(4):279-90.
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1997: Malech H L; Maples P B; Whiting-Theobald N; Linton G F; Sekhsaria S; Vowells S J; Li F; Miller J A; DeCarlo E; Holland S M; Leitman S F; Carter C S; Butz R E; Read E J; Fleisher T A; Schneiderman R D; Van Epps D E; Spratt S K; Maack C A; Rokovich J A; Cohen L K; Gallin J I
Prolonged production of NADPH oxidase-corrected granulocytes after gene therapy of chronic granulomatous disease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):12133-8.
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1997: Mardiney M; Jackson S H; Spratt S K; Li F; Holland S M; Malech H L
Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease.
Blood 1997;89(7):2268-75.
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1997: Weil W M; Linton G F; Whiting-Theobald N; Vowells S J; Rafferty S P; Li F; Malech H L
Genetic correction of p67phox deficient chronic granulomatous disease using peripheral blood progenitor cells as a target for retrovirus mediated gene transfer.
Blood 1997;89(5):1754-61.
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1996: Domachowske J B; Rafferty S P; Singhania N; Mardiney M; Malech H L
Nitric oxide alters the expression of gamma-globin, H-ferritin, and transferrin receptor in human K562 cells at the posttranscriptional level.
Blood 1996;88(8):2980-8.
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1996: Shalit M; Sekhsaria S; Mauhorter S; Mahanti S; Malech H L
Early commitment to the eosinophil lineage by cultured human peripheral blood CD34+ cells: messenger RNA analysis.
The Journal of allergy and clinical immunology 1996;98(2):344-54.
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1996: Sekhsaria S; Fleisher T A; Vowells S; Brown M; Miller J; Gordon I; Blaese R M; Dunbar C E; Leitman S; Malech H L
Granulocyte colony-stimulating factor recruitment of CD34+ progenitors to peripheral blood: impaired mobilization in chronic granulomatous disease and adenosine deaminase--deficient severe combined immunodeficiency disease patients.
Blood 1996;88(3):1104-12.
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1996: Rafferty S P; Domachowske J B; Malech H L
Inhibition of hemoglobin expression by heterologous production of nitric oxide synthase in the K562 erythroleukemic cell line.
Blood 1996;88(3):1070-8.
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1996: Ahuja S S; Brown M R; Fleisher T A; Ahuja S K; Malech H L
Autocrine activation of hemopoietic progenitor-derived myelo-monocytic cells by IFN-gamma gene transfer.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(11):4345-53.
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1996: Mardiney M; Malech H L
Enhanced engraftment of hematopoietic progenitor cells in mice treated with granulocyte colony-stimulating factor before low-dose irradiation: implications for gene therapy.
Blood 1996;87(10):4049-56.
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1996: Vowells S J; Fleisher T A; Malech H L
Testing for chronic granulomatous disease.
Lancet 1996;347(9007):1048-9.
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1996: de Mendez I; Adams A G; Sokolic R A; Malech H L; Leto T L
Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells.
The EMBO journal 1996;15(6):1211-20.
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1996: Rafferty S; Malech H L
High reductase activity of recombinant NOS2 flavoprotein domain lacking the calmodulin binding regulatory sequence.
Biochemical and biophysical research communications 1996;220(3):1002-7.
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1996: Vowells S J; Fleisher T A; Sekhsaria S; Alling D W; Maguire T E; Malech H L
Genotype-dependent variability in flow cytometric evaluation of reduced nicotinamide adenine dinucleotide phosphate oxidase function in patients with chronic granulomatous disease.
The Journal of pediatrics 1996;128(1):104-7.
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1996: Sokolic R A; Sekhsaria S; Sugimoto Y; Whiting-Theobald N; Linton G F; Li F; Gottesman M M; Malech H L
A bicistronic retrovirus vector containing a picornavirus internal ribosome entry site allows for correction of X-linked CGD by selection for MDR1 expression.
Blood 1996;87(1):42-50.
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1995: Vowells S J; Sekhsaria S; Malech H L; Shalit M; Fleisher T A
Flow cytometric analysis of the granulocyte respiratory burst: a comparison study of fluorescent probes.
Journal of immunological methods 1995;178(1):89-97.
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1995: Shalit M; Sekhsaria S; Malech H L
Modulation of growth and differentiation of eosinophils from human peripheral blood CD34+ cells by IL5 and other growth factors.
Cellular immunology 1995;160(1):50-7.
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1994: Wright D G; Kenney R F; Oette D H; LaRussa V F; Boxer L A; Malech H L
Contrasting effects of recombinant human granulocyte-macrophage colony-stimulating factor (CSF) and granulocyte CSF treatment on the cycling of blood elements in childhood-onset cyclic neutropenia.
Blood 1994;84(4):1257-67.
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1994: Li F; Linton G F; Sekhsaria S; Whiting-Theobald N; Katkin J P; Gallin J I; Malech H L
CD34+ peripheral blood progenitors as a target for genetic correction of the two flavocytochrome b558 defective forms of chronic granulomatous disease.
Blood 1994;84(1):53-8.
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1994: Kleinberg M E; Malech H L; Mital D A; Leto T L
p21rac does not participate in the early interaction between p47-phox and cytochrome b558 that leads to phagocyte NADPH oxidase activation in vitro.
Biochemistry 1994;33(9):2490-5.
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1994: Jackson S H; Malech H L; Kozak C A; Lomax K J; Gallin J I; Holland S M
Cloning and functional expression of the mouse homologue of p47phox.
Immunogenetics 1994;39(4):272-5.
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1993: Kenney R T; Malech H L; Epstein N D; Roberts R L; Leto T L
Characterization of the p67phox gene: genomic organization and restriction fragment length polymorphism analysis for prenatal diagnosis in chronic granulomatous disease.
Blood 1993;82(12):3739-44.
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1993: Sekhsaria S; Gallin J I; Linton G F; Mallory R M; Mulligan R C; Malech H L
Peripheral blood progenitors as a target for genetic correction of p47phox-deficient chronic granulomatous disease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7446-50.
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1993: Kwong C H; Malech H L; Rotrosen D; Leto T L
Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.
Biochemistry 1993;32(21):5711-7.
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1993: Sekhsaria S; Malech H L
Recombinant human stem cell factor enhances myeloid colony growth from human peripheral blood progenitors.
Blood 1993;81(8):2125-30.
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1992: Rotrosen D; Yeung C L; Leto T L; Malech H L; Kwong C H
Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase.
Science (New York, N.Y.) 1992;256(5062):1459-62.
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1992: Cobbs C S; Malech H L; Leto T L; Freeman S M; Blaese R M; Gallin J I; Lomax K J
Retroviral expression of recombinant p47phox protein by Epstein-Barr virus-transformed B lymphocytes from a patient with autosomal chronic granulomatous disease.
Blood 1992;79(7):1829-35.
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1992: Kleinberg M E; Mital D; Rotrosen D; Malech H L
Characterization of a phagocyte cytochrome b558 91-kilodalton subunit functional domain: identification of peptide sequence and amino acids essential for activity.
Biochemistry 1992;31(10):2686-90.
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1992: Gallin J I; Leto T L; Rotrosen D; Kwong C H; Malech H L
Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhood.
Current opinion in immunology 1992;4(1):53-6.
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1991: Rex J H; Bennett J E; Gallin J I; Malech H L; DeCarlo E S; Melnick D A
In vivo interferon-gamma therapy augments the in vitro ability of chronic granulomatous disease neutrophils to damage Aspergillus hyphae.
The Journal of infectious diseases 1991;163(4):849-52.
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1991: Brown C C; Malech H L; Jacobson R J; Shrimpton C F; Beverly P C; Segal A W; Gallin J I
Unique human neutrophil populations are defined by monoclonal antibody ED12F8C10.
Cellular immunology 1991;132(1):102-14.
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1990: Levy R; Rotrosen D; Nagauker O; Leto T L; Malech H L
Induction of the respiratory burst in HL-60 cells. Correlation of function and protein expression.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(8):2595-601.
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1990: Kenney R T; Kwon-Chung K J; Witebsky F G; Melnick D A; Malech H L; Gallin J I
Invasive infection with Sarcinosporon inkin in a patient with chronic granulomatous disease.
American journal of clinical pathology 1990;94(3):344-50.
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1990: Francke U; Hsieh C L; Foellmer B E; Lomax K J; Malech H L; Leto T L
Genes for two autosomal recessive forms of chronic granulomatous disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1).
American journal of human genetics 1990;47(3):483-92.
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1990: Kleinberg M E; Malech H L; Rotrosen D
The phagocyte 47-kilodalton cytosolic oxidase protein is an early reactant in activation of the respiratory burst.
The Journal of biological chemistry 1990;265(26):15577-83.
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1990: Levy R; Malech H L; Rotrosen D
Production of myeloid cell cytosols functionally and immunochemically deficient in the 47 kDa or 67 kDa NADPH oxidase cytosolic factors.
Biochemical and biophysical research communications 1990;170(3):1114-20.
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1990: Rex J H; Bennett J E; Gallin J I; Malech H L; Melnick D A
Normal and deficient neutrophils can cooperate to damage Aspergillus fumigatus hyphae.
The Journal of infectious diseases 1990;162(2):523-8.
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1990: Rotrosen D; Kleinberg M E; Nunoi H; Leto T; Gallin J I; Malech H L
Evidence for a functional cytoplasmic domain of phagocyte oxidase cytochrome b558.
The Journal of biological chemistry 1990;265(15):8745-50.
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1990: Leto T L; Lomax K J; Volpp B D; Nunoi H; Sechler J M; Nauseef W M; Clark R A; Gallin J I; Malech H L
Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src.
Science (New York, N.Y.) 1990;248(4956):727-30.
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1990: Murphy P M; Malech H L
Nucleotide sequence of a cDNA encoding a protein with primary structural similarity to G-protein coupled receptors.
Nucleic acids research 1990;18(7):1896.
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1990: Gallin J I; Malech H L
Update on chronic granulomatous diseases of childhood. Immunotherapy and potential for gene therapy.
JAMA : the journal of the American Medical Association 1990;263(11):1533-7.
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1990: Murphy P M; Gallin E K; Tiffany H L; Malech H L
The formyl peptide chemoattractant receptor is encoded by a 2 kilobase messenger RNA. Expression in Xenopus oocytes.
FEBS letters 1990;261(2):353-7.
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1989: Kleinberg M E; Rotrosen D; Malech H L
Asparagine-linked glycosylation of cytochrome b558 large subunit varies in different human phagocytic cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(12):4152-7.
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1989: King C L; Gallin J I; Malech H L; Abramson S L; Nutman T B
Regulation of immunoglobulin production in hyperimmunoglobulin E recurrent-infection syndrome by interferon gamma.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(24):10085-9.
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1989: Lomax K J; Leto T L; Nunoi H; Gallin J I; Malech H L
Minor errors in two published sequences.
Science (New York, N.Y.) 1989;246(4933):987.
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1989: Brown C C; Malech H L; Gallin J I
Intravenous endotoxin recruits a distinct subset of human neutrophils, defined by monoclonal antibody 31D8, from bone marrow to the peripheral circulation.
Cellular immunology 1989;123(2):294-306.
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1989: Clark R A; Malech H L; Gallin J I; Nunoi H; Volpp B D; Pearson D W; Nauseef W M; Curnutte J T
Genetic variants of chronic granulomatous disease: prevalence of deficiencies of two cytosolic components of the NADPH oxidase system.
The New England journal of medicine 1989;321(10):647-52.
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1989: Lomax K J; Leto T L; Nunoi H; Gallin J I; Malech H L
Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease.
Science (New York, N.Y.) 1989;245(4916):409-12.
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1989: Lomax K J; Gallin J I; Rotrosen D; Raphael G D; Kaliner M A; Benz E J; Boxer L A; Malech H L
Selective defect in myeloid cell lactoferrin gene expression in neutrophil specific granule deficiency.
The Journal of clinical investigation 1989;83(2):514-9.
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1988: Nunoi H; Rotrosen D; Gallin J I; Malech H L
Two forms of autosomal chronic granulomatous disease lack distinct neutrophil cytosol factors.
Science (New York, N.Y.) 1988;242(4883):1298-301.
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1988: Rotrosen D; Gallin J I; Spiegel A M; Malech H L
Subcellular localization of Gi alpha in human neutrophils.
The Journal of biological chemistry 1988;263(22):10958-64.
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1988: Sechler J M; Malech H L; White C J; Gallin J I
Recombinant human interferon-gamma reconstitutes defective phagocyte function in patients with chronic granulomatous disease of childhood.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4874-8.
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1988: Gallin J I; Sechler J M; Malech H L
Reconstitution of defective phagocyte function in chronic granulomatous disease of childhood with recombinant human interferon-gamma.
Transactions of the Association of American Physicians 1988;101():12-7.
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1987: Rotrosen D; Malech H L; Gallin J I
Formyl peptide leukocyte chemoattractant uptake and release by cultured human umbilical vein endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(9):3034-40.
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