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Thomas Malek

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Jessica J Ashbaugh; Roberta Brambilla; Cecilia Cabello; Shaffiat A Karmally; Thomas R Malek; John R Bethea
IL7Rα Contributes to Experimental Autoimmune Encephalomyelitis through Altered T Cell Responses and Nonhematopoietic Cell Lineages.
Guoyan Cheng; Michael J Dee; Aixin Yu; Thomas R Malek
IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development.
Iris Castro; Michael J Dee; Thomas R Malek
Transient enhanced IL-2R signaling early during priming rapidly amplifies development of functional CD8+ T effector-memory cells.

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2013: Jessica J Ashbaugh; Roberta Brambilla; Cecilia Cabello; Shaffiat A Karmally; Thomas R Malek; John R Bethea
IL7Rα Contributes to Experimental Autoimmune Encephalomyelitis through Altered T Cell Responses and Nonhematopoietic Cell Lineages.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(9):4525-34.
2013: Guoyan Cheng; Michael J Dee; Aixin Yu; Thomas R Malek
IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(4):1567-75.
2012: Iris Castro; Michael J Dee; Thomas R Malek
Transient enhanced IL-2R signaling early during priming rapidly amplifies development of functional CD8+ T effector-memory cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(9):4321-30.
2012: Guoyan Cheng; Eckhard R Podack; Matthew S Tsai; Aixin Yu; Xiaomei Yuan; Thomas R Malek
IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(4):1780-91.
2012: Xiaomei Yuan; Thomas R Malek
Cellular and molecular determinants for the development of natural and induced regulatory T cells.
Human immunology 2012;73(8):773-82.
2012: Thomas R Malek; Wasif Khan
IL-2: fine-tuning the germinal center reaction.
Immunity 2012;36(5):702-4.
2011: Allison L Bayer; Cecilia Cabello; Julio A Chirinos; Thomas R Malek; Takaji Matsutani; Jing Yang; Robert B Levy
Expansion of a restricted residual host T reg-cell repertoire is dependent on IL-2 following experimental autologous hematopoietic stem transplantation.
European journal of immunology 2011;41(12):3467-78.
2011: Iris Castro; Michael J Dee; Aixin Yu; Thomas R Malek
The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(10):5170-82.
2011: Thomas R Malek; Alberto Pugliese
Low-dose IL-2 as a therapeutic agent for tolerance induction.
Immunotherapy 2011;3(11):1281-4.
2011: Guoyan Cheng; Aixin Yu; Thomas R Malek
T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells.
Immunological reviews 2011;241(1):63-76.
2010: Taylor Schreiber; Dietlinde Wolf; Matthew S Tsai; Jackie Chirinos; Vadim V Deyev; Louis Gonzalez; Thomas R Malek; Robert B Levy; Eckhard R Podack
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation.
The Journal of clinical investigation 2010;120(10):3629-40.
2010: Thomas R Malek; Iris Castro
Interleukin-2 receptor signaling: at the interface between tolerance and immunity.
Immunity 2010;33(2):153-65.
2010: Dennis Adeegbe; Robert B Levy; Thomas R Malek
Allogeneic T regulatory cell-mediated transplantation tolerance in adoptive therapy depends on dominant peripheral suppression and central tolerance.
Blood 2010;115(10):1932-40.
2010: Dennis Adeegbe; Takaji Matsutani; Jing Yang; Norman Altman; Thomas R Malek
CD4(+) CD25(+) Foxp3(+) T regulatory cells with limited TCR diversity in control of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(1):56-66.
2009: Aixin Yu; Linjian Zhu; Norman Altman; Thomas R Malek
A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells.
Immunity 2009;30(2):204-17.
2009: Allison L Bayer; Monica Jones; Julio A Chirinos; Lesley de Armas; Taylor Schreiber; Thomas R Malek; Robert B Levy
Host CD4+CD25+ T cells can expand and comprise a major component of the Treg compartment after experimental HCT.
Blood 2009;113(3):733-43.
2008: Thomas R Malek; Aixin Yu; Linjian Zhu; Takaji Matsutani; Dennis Adeegbe; Allison L Bayer
IL-2 family of cytokines in T regulatory cell development and homeostasis.
Journal of clinical immunology 2008;28(6):635-9.
2008: Allison L Bayer; Joon Youb Lee; Anabel de la Barrera; Charles D Surh; Thomas R Malek
A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):225-34.
2008: Cleo E Rolle; Roberto Carrio Jardines; Thomas R Malek
Modeling the CD8+ T effector to memory transition in adoptive T-cell antitumor immunotherapy.
Cancer research 2008;68(8):2984-92.
2008: Thomas R Malek
The biology of interleukin-2.
Annual review of immunology 2008;26():453-79.
2007: Roberto Carrio Jardines; Cleo E Rolle; Thomas R Malek
Non-redundant role for IL-7R signaling for the survival of CD8+ memory T cells.
European journal of immunology 2007;37(11):3078-88.
2007: Allison L Bayer; Aixin Yu; Thomas R Malek
Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4062-71.
2007: Dapeng Gong; Thomas R Malek
Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):242-52.
2006: Haoli Jin; Thomas R Malek
Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21.
Journal of leukocyte biology 2006;80(6):1416-23.
2006: Aixin Yu; Thomas R Malek
Selective availability of IL-2 is a major determinant controlling the production of CD4+CD25+Foxp3+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5115-21.
2006: Dennis Adeegbe; Allison L Bayer; Robert B Levy; Thomas R Malek
Cutting edge: allogeneic CD4+CD25+Foxp3+ T regulatory cells suppress autoimmunity while establishing transplantation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7149-53.
2006: Haoli Jin; Dapeng Gong; Dennis Adeegbe; Allison L Bayer; Cleo E Rolle; Aixin Yu; Thomas R Malek
Quantitative assessment concerning the contribution of IL-2Rbeta for superantigen-mediated T cell responses in vivo.
International immunology 2006;18(4):565-72.
2005: Allison L Bayer; Aixin Yu; Dennis Adeegbe; Thomas R Malek
Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period.
The Journal of experimental medicine 2005;201(5):769-77.
2004: Thomas R Malek; Allison L Bayer
Tolerance, not immunity, crucially depends on IL-2.
Nature reviews. Immunology 2004;4(9):665-74.
2004: Haoli Jin; Roberto Carrio Jardines; Aixin Yu; Thomas R Malek
Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):657-65.
2004: Roberto Carrio Jardines; Oliver F Bathe; Thomas R Malek
Initial antigen encounter programs CD8+ T cells competent to develop into memory cells that are activated in an antigen-free, IL-7- and IL-15-rich environment.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7315-23.
2003: Thomas R Malek
The main function of IL-2 is to promote the development of T regulatory cells.
Journal of leukocyte biology 2003;74(6):961-5.
2003: Oliver F Bathe; Nava Dalyot-Herman; Thomas R Malek
Therapeutic limitations in tumor-specific CD8+ memory T cell engraftment.
BMC cancer 2003;3():21.
2003: R. Damaris Molano; Antonello Pileggi; Thierry Berney; Raffaella Poggioli; Elsie Zahr; Robert Oliver; Thomas R Malek; Camillo Ricordi; Luca Inverardi
Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, rapamycin, and anti-interleukin-2 antibody.
Transplantation 2003;75(11):1812-9.
2003: Aixin Yu; Jiehao Zhou; Norman W Marten; Cornelia C Bergmann; Michele Mammolenti; Robert B Levy; Thomas R Malek
Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):236-42.
2002: Thomas R Malek
T helper cells, IL-2 and the generation of cytotoxic T-cell responses.
Trends in immunology 2002;23(10):465-7.
2002: Thomas R Malek; Aixin Yu; Vladimir Vincek; Paul Scibelli; Lin Kong
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2.
Immunity 2002;17(2):167-78.
2002: Gülçin Demirci; Wenda Gao; Xin Xiao Zheng; Thomas R Malek; Terry B Strom; Xian Chang Li
On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4382-90.
2002: Ferenc Olosz; Thomas R Malek
Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain.
The Journal of biological chemistry 2002;277(14):12047-52.
2001: Oliver F Bathe; Nava Dalyot-Herman; Thomas R Malek
IL-2 during in vitro priming promotes subsequent engraftment and successful adoptive tumor immunotherapy by persistent memory phenotypic CD8(+) T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4511-7.
2001: J W Lowenthal; Thomas R Malek; H Saragovi
Measurement of lymphokine receptors.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 6():Unit 6.1.
2001: Thomas R Malek; Aixin Yu; Paul Scibelli; Mathias G Lichtenheld; EK Codias
Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1675-83.
2001: Aixin Yu; Thomas R Malek
The proteasome regulates receptor-mediated endocytosis of interleukin-2.
The Journal of biological chemistry 2001;276(1):381-5.
2001: Xian Chang Li; Gülçin Demirci; Sylvie Ferrari-Lacraz; C Groves; Anthony J Coyle; Thomas R Malek; Terry B Strom
IL-15 and IL-2: a matter of life and death for T cells in vivo.
Nature medicine 2001;7(1):114-8.
2001: BO Porter; Paul Scibelli; Thomas R Malek
Control of T cell development in vivo by subdomains within the IL-7 receptor alpha-chain cytoplasmic tail.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):262-9.
2000: Nava Dalyot-Herman; Oliver F Bathe; Thomas R Malek
Reversal of CD8+ T cell ignorance and induction of anti-tumor immunity by peptide-pulsed APC.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6731-7.
2000: BO Porter; Thomas R Malek
Thymic and intestinal intraepithelial T lymphocyte development are each regulated by the gammac-dependent cytokines IL-2, IL-7, and IL-15.
Seminars in immunology 2000;12(5):465-74.
2000: Ferenc Olosz; Thomas R Malek
Three loops of the common gamma chain ectodomain required for the binding of interleukin-2 and interleukin-7.
The Journal of biological chemistry 2000;275(39):30100-5.
2000: Aixin Yu; Ferenc Olosz; C Y Choi; Thomas R Malek
Efficient internalization of IL-2 depends on the distal portion of the cytoplasmic tail of the IL-2R common gamma-chain and a lymphoid cell environment.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2556-62.
2000: EK Codias; Ferenc Olosz; Thomas R Malek
Genomic organization and 5' regulatory region of the mouse IL-2 receptor beta-chain gene (IL-2Rb).
Immunogenetics 2000;51(6):508-12.
2000: Thomas R Malek; BO Porter; EK Codias; Paul Scibelli; Aixin Yu
Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):2905-14.
2000: Xian Chang Li; A Ima; Yongsheng Li; Xin Xiao Zheng; Thomas R Malek; Terry B Strom
Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1193-9.
1999: BO Porter; Thomas R Malek
IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: roles for both IL-2 and IL-15 in CD8alphaalpha IEL development.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):5906-12.
1999: MD Marmor; Martin F Bachmann; Pamela S Ohashi; Thomas R Malek; Michael Julius
Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function.
International immunology 1999;11(9):1381-93.
1999: BO Porter; Thomas R Malek
Prostaglandin E2 inhibits T cell activation-induced apoptosis and Fas-mediated cellular cytotoxicity by blockade of Fas-ligand induction.
European journal of immunology 1999;29(7):2360-5.
1999: Thomas R Malek; BO Porter; You-Wen He
Multiple gamma c-dependent cytokines regulate T-cell development.
Immunology today 1999;20(2):71-6.
1998: Xian Chang Li; P Roy-Chaudhury; Wayne W Hancock; RC Manfro; MS Zand; Yongsheng Li; Xin Xiao Zheng; PW Nickerson; J Steiger; Thomas R Malek; Terry B Strom
IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):890-6.
1998: Thomas R Malek; Robert B Levy; Rebecca Adkins; You-Wen He
Monoclonal antibodies to the common gamma-chain as cytokine receptor antagonists in vivo: effect on intrathymic and intestinal intraepithelial T lymphocyte development.
Journal of leukocyte biology 1998;63(6):643-9.
1998: You-Wen He; Thomas R Malek
The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis.
Critical reviews in immunology 1998;18(6):503-24.
1997: V N Ivanov; Richard Lee; Eckhard R Podack; Thomas R Malek
Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: a potential role for transcription factor NF-kappa B.
Oncogene 1997;14(20):2455-64.
1997: Annette J Schlueter; Thomas R Malek; C N Hostetler; P A Smith; P deVries; Thomas J Waldschmidt
Distribution of Ly-6C on lymphocyte subsets: I. Influence of allotype on T lymphocyte expression.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4211-22.
1997: You-Wen He; H Nakajima; Warren J Leonard; Rebecca Adkins; Thomas R Malek
The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2592-9.
1996: You-Wen He; Thomas R Malek
Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.
The Journal of experimental medicine 1996;184(1):289-93.
1996: B Liu; Eckhard R Podack; James P Allison; Thomas R Malek
Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1117-25.
1995: V N Ivanov; G Deng; Eckhard R Podack; Thomas R Malek
Pleiotropic effects of Bcl-2 on transcription factors in T cells: potential role of NF-kappa B p50-p50 for the anti-apoptotic function of Bcl-2.
International immunology 1995;7(11):1709-20.
1995: You-Wen He; Thomas R Malek
The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(1):9-12.
1995: You-Wen He; Robert B Levy; Thomas R Malek
Blockade of T- and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5689-93.
1995: Thomas R Malek; R K Furse; M L Fleming; A J Fadell; You-Wen He
Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(5):447-54.
1995: You-Wen He; Rebecca Adkins; R K Furse; Thomas R Malek
Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(4):1596-605.
1994: N S Gutgsell; Thomas R Malek
Formation of high affinity IL-2 receptors is dependent on a nonligand binding region of the alpha subunit.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(9):3899-907.
1994: V Ivanov; T J Fleming; Thomas R Malek
Regulation of nuclear factor-kappa B and activator protein-1 activities after stimulation of T cells via glycosylphosphatidylinositol-anchored Ly-6A/E.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2394-406.
1994: T J Fleming; Thomas R Malek
Multiple glycosylphosphatidylinositol-anchored Ly-6 molecules and transmembrane Ly-6E mediate inhibition of IL-2 production.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):1955-62.
1994: Thomas R Malek; T J Fleming; E K Codias
Regulation of T lymphocyte function by glycosylphosphatidylinositol (GPI)-anchored proteins.
Seminars in immunology 1994;6(2):105-13.
1993: R K Furse; Thomas R Malek
Selection of internalization-deficient cells by interleukin-2-Pseudomonas exotoxin chimeric protein: the cytoplasmic domain of the interleukin-2 receptor beta chain does not contribute to internalization of interleukin-2.
European journal of immunology 1993;23(12):3181-8.
1993: E K Codias; Thomas R Malek
Subsets of activated CD4 T lymphocytes refractory for secretion of IL-2 are distinguished by expression of Ly-6A/E in BALB/c mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):5918-29.
1993: T J Fleming; M L Fleming; Thomas R Malek
Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2399-408.
1993: Clifford Mintz; Richard D Miller; N S Gutgsell; Thomas R Malek
Legionella pneumophila protease inactivates interleukin-2 and cleaves CD4 on human T cells.
Infection and immunity 1993;61(8):3416-21.
1993: T J Fleming; Colm O'hUigin; Thomas R Malek
Characterization of two novel Ly-6 genes. Protein sequence and potential structural similarity to alpha-bungarotoxin and other neurotoxins.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(12):5379-90.
1993: Thomas R Malek; Vladimir Vincek; B Gatalica; Maja Bucan
The IL-2 receptor beta chain gene (Il-2rb) is closely linked to the Pdgfb locus on mouse chromosome 15.
Immunogenetics 1993;38(2):154-6.
1992: E K Codias; T J Fleming; C M Zacharchuk; Jonathan D Ashwell; Thomas R Malek
Role of Ly-6A/E and T cell receptor-zeta for IL-2 production. Phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor-mediated IL-2 production by a zeta-independent pathway.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(6):1825-52.
1990: E K Codias; J E Rutter; T J Fleming; Thomas R Malek
Down-regulation of IL-2 production by activation of T cells through Ly-6A/E.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(5):1407-14.
1990: Carolyn Cray; Robert W Keane; Thomas R Malek; Robert B Levy
Regulation and selective expression of Ly-6A/E, a lymphocyte activation molecule, in the central nervous system.
Brain research. Molecular brain research 1990;8(1):9-15.
1990: E K Codias; Thomas R Malek
Regulation of B lymphocyte responses to IL-4 and IFN-gamma by activation through Ly-6A/E molecules.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(6):2197-204.
1990: H Saragovi; Thomas R Malek
Evidence for additional subunits associated to the mouse interleukin 2 receptor p55/p75 complex.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):11-5.
1990: R L Hendricks; Thomas R Malek; Beatrice Y J T Yue
Expression of a p55 interleukin-2 receptor-like molecule on corneal epithelial cells.
Regional immunology 1990;3(1):29-34.
1989: Thomas R Malek; E M Shevach; K M Danis
Activation of T lymphocytes through the Ly-6 pathway is defective in A strain mice.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(2):439-45.
1989: Thomas R Malek; K M Danis; E K Codias
Tumor necrosis factor synergistically acts with IFN-gamma to regulate Ly-6A/E expression in T lymphocytes, thymocytes and bone marrow cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(6):1929-36.
1989: E K Codias; Carolyn Cray; Ruben Baler; Robert B Levy; Thomas R Malek
Expression of Ly-6A/E alloantigens in thymocyte and T-lymphocyte subsets: variability related to the Ly-6a and Ly-6b haplotypes.
Immunogenetics 1989;29(2):98-107.
1988: H Saragovi; Thomas R Malek
Direct identification of the murine IL-2 receptor p55-p75 heterodimer in the absence of IL-2.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(2):476-82.
1988: Robert B Levy; A H Cotterell; M Jones; Thomas R Malek
Graft-versus-host reaction-induced immune modulation. I. Donor-recipient genetic disparity and the differential expression of Lyt-2, L3T4, and Ly-6 during acute reactions in the host thymus.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(6):1717-25.
1987: H Saragovi; Thomas R Malek
The murine interleukin 2 receptor. Irreversible cross-linking of radiolabeled interleukin 2 to high affinity interleukin 2 receptors reveals a noncovalently associated subunit.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(6):1918-26.
1987: J L Moreau; M Nabholz; T Diamantstein; Thomas R Malek; E Shevach; J Thèze
Monoclonal antibodies identify three epitope clusters on the mouse p55 subunit of the interleukin 2 receptor: relationship to the interleukin 2-binding site.
European journal of immunology 1987;17(7):929-35.
1986: G Ortega; P E Korty; E M Shevach; Thomas R Malek
Role of Ly-6 in lymphocyte activation. I. Characterization of a monoclonal antibody to a nonpolymorphic Ly-6 specificity.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(10):3240-6.
1986: J D Ashwell; R J Robb; Thomas R Malek
Proliferation of T lymphocytes in response to interleukin 2 varies with their state of activation.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(8):2572-8.
1986: F D Finkelman; Thomas R Malek; E M Shevach; J J Mond
In vivo and in vitro expression of an interleukin 2 receptor by murine B and T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(7):2252-9.
1986: Thomas R Malek; G Ortega; C Chan; R A Kroczek; E M Shevach
Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies.
The Journal of experimental medicine 1986;164(3):709-22.
1986: Thomas R Malek; J D Ashwell; R N Germain; E M Shevach; J Miller
The murine interleukin-2 receptor: biochemical structure and regulation of expression.
Immunological reviews 1986;92():81-101.
1986: D K Wagner; J York-Jolley; Thomas R Malek; J A Berzofsky; D L Nelson
Antigen-specific murine T cell clones produce soluble interleukin 2 receptor on stimulation with specific antigens.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(2):592-6.
1986: G Steiner; E Tschachler; M Tani; Thomas R Malek; E M Shevach; W Holter; W Knapp; K Wolff; G Stingl
Interleukin 2 receptors on cultured murine epidermal Langerhans cells.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(1):155-9.
1986: Thomas R Malek; P E Korty
The murine interleukin 2 receptor. IV. Biochemical characterization.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(11):4092-8.
1986: T Mizuochi; S Ono; Thomas R Malek; A Singer
Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens.
The Journal of experimental medicine 1986;163(3):603-19.
1985: K L McCoy; P J Baker; Thomas R Malek; T M Chused
Enlargement of Lyt-2-positive T cells is associated with functional impairment and autoimmune hemolytic anemia in New Zealand Black mice.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(4):2432-7.
1985: L J Joseph; T Iwasaki; Thomas R Malek; G M Shearer
Interleukin 2 receptor dysfunction in mice undergoing a graft-vs-host reaction.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(3):1846-50.
1985: Thomas R Malek; C Chan; L H Glimcher; R N Germain; E M Shevach
Influence of accessory cell and T cell surface antigens on mitogen-induced IL 2 receptor expression.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(3):1826-33.
1985: T Mizuochi; Hana Golding; Amy S Rosenberg; L H Glimcher; Thomas R Malek; A Singer
Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self.
The Journal of experimental medicine 1985;162(2):427-43.
1985: Thomas R Malek; J D Ashwell
Interleukin 2 upregulates expression of its receptor on a T cell clone.
The Journal of experimental medicine 1985;161(6):1575-80.
1985: J Miller; Thomas R Malek; Warren J Leonard; Warner Greene; E M Shevach; R N Germain
Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(6):4212-7.
1985: S S Yang; Thomas R Malek; M E Hargrove; Chou-Chik Ting
Lymphokine-induced cytotoxicity: requirement of two lymphokines for the induction of optimal cytotoxic response.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(6):3912-9.
1985: Y J Rosenberg; Thomas R Malek; D E Schaeffer; Thomas J. Santoro; G E Mark; A D Steinberg; J D Mountz
Unusual expression of IL 2 receptors and both the c-myb and c-raf oncogenes in T cell lines and clones derived from autoimmune MRL-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(5):3120-3.
1985: Thomas R Malek; J A Schmidt; E M Shevach
The murine IL 2 receptor. III. Cellular requirements for the induction of IL 2 receptor expression on T cell subpopulations.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(4):2405-13.
1985: M E Andrew; A M Churilla; Thomas R Malek; Vivian L Braciale; Thomas J Braciale
Activation of virus specific CTL clones: antigen-dependent regulation of interleukin 2 receptor expression.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(2):920-5.
1984: K Nakanishi; Thomas R Malek; Kendall A Smith; T Hamaoka; E M Shevach; William Paul
Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis.
The Journal of experimental medicine 1984;160(6):1605-21.
1984: Thomas R Malek; G Ortega; J P Jakway; C Chan; E M Shevach
The murine IL 2 receptor. II. Monoclonal anti-IL 2 receptor antibodies as specific inhibitors of T cell function in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(4):1976-82.
1984: G Ortega; R J Robb; E M Shevach; Thomas R Malek
The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(4):1970-5.
1984: J Kaye; S Gillis; S B Mizel; E M Shevach; Thomas R Malek; C A Dinarello; L B Lachman; C A Janeway
Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(3):1339-45.
1984: H S Lillehoj; Thomas R Malek; E M Shevach
Differential effect of cyclosporin A on the expression of T and B lymphocyte activation antigens.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(1):244-50.
1984: Thomas R Malek; E M Shevach
Interleukin 2-driven T lymphocyte proliferation is dependent upon a surface antigen distinct from the interleukin 2 receptor: requirements for inhibition of T-cell proliferation by monoclonal antibody 5C3.
Cellular immunology 1984;84(1):85-93.
1984: K C Gunter; Thomas R Malek; E M Shevach
T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4.
The Journal of experimental medicine 1984;159(3):716-30.
1984: Thomas J. Santoro; Thomas R Malek; Y J Rosenberg; Herbert Carpenter Morse; A D Steinberg
Signals required for activation and growth of autoimmune T lymphocytes.
The Journal of molecular and cellular immunology : JMCI 1984;1(6):347-56.
1983: M Howard; L Matis; Thomas R Malek; E Shevach; W Kell; D Cohen; K Nakanishi; William Paul
Interleukin 2 induces antigen-reactive T cell lines to secrete BCGF-I.
The Journal of experimental medicine 1983;158(6):2024-39.
1983: Thomas R Malek; L T Clement; E M Shevach
The cellular compartmentalization of macrophage-associated nominal antigen: immunologically relevant macrophage-associated antigen may not require an intracellular phase of macrophage handling.
European journal of immunology 1983;13(10):810-5.
1983: Thomas R Malek; R J Robb; E M Shevach
Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(18):5694-8.
1983: Thomas R Malek; R J Robb; E M Shevach
Identification of a membrane antigen that is distinct from the interleukin 2 receptor and that may be required for interleukin 2-driven proliferative responses.
Journal of immunology (Baltimore, Md. : 1950) 1983;130(2):747-55.
1982: Thomas R Malek; E M Shevach
Nature of the antigenic complex recognized by T lymphocytes. IX. Direct immunochemical demonstration of nominal antigen on the macrophage cell surface.
European journal of immunology 1982;12(10):825-31.
1981: Thomas R Malek; E M Shevach
Alloreactive T cells from individual soft agar colonies specific for guinea pig Ia antigens. II. Cellular and molecular requirements for optimal proliferative responses.
Journal of immunology (Baltimore, Md. : 1950) 1981;127(5):2113-8.
1981: Thomas R Malek; R B Clark; E M Shevach
Alloreactive T cells from individual soft agar colonies specific for guinea pig Ia antigens. I. Production and initial characterization.
Journal of immunology (Baltimore, Md. : 1950) 1981;127(2):616-21.
1978: Thomas R Malek; B E Peterson; W C Hanly; K L Knight; Bernard Friedenson
Structural studies of rabbit IgA allotypes: partial amino acid sequences of alpha-chain allotypes controlled by allelic genes at the Calphag locus.
Journal of immunology (Baltimore, Md. : 1950) 1978;120(3):950-4.
1978: K L Knight; Bernard Friedenson; W C Hanly; Thomas R Malek; B E Peterson
Serologic and structural comparisons of rabbit IgA allotypes.
Advances in experimental medicine and biology 1978;107():513-22.
1977: Thomas R Malek; K L Knight
Digestion of the "proteolytic resistant" f-subclass of rabbit secretory IgA. Localization of f-subclass allotypic specificities to the Fc2alpha fragment.
Immunochemistry 1977;14(7):493-6.
1975: K L Knight; M L Vetter; Thomas R Malek
Distribution of covalently bound and non-covalently bound secretory component on sbuclasses of rabbit secretory IgA.
Journal of immunology (Baltimore, Md. : 1950) 1975;115(2):595-8.
1975: K L Knight; Thomas R Malek; S Dray
Human immunoglobulins with a1 allotypic determinants of rabbit immunoglobulin heavy chains.
Nature 1975;253(5488):216-7.
1974: Thomas R Malek; W C Hanly; K L Knight
Papain-resistant (f) and papain-sensitive (g) subclasses of rabbit sLgA. Allotypic specificities on different domains of the g subclass of alpha-chains (alpha g).
European journal of immunology 1974;4(10):692-7.
1974: K L Knight; Thomas R Malek; W C Hanly
Recombinant rabbit secretory immunoglobulin molecules: alpha chains with maternal (paternal) variable-region allotypes and paternal (maternal) constant-region allotypes.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(4):1169-73.