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Frank Maley

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Ruth L Saxl; Gladys F Maley; Charles R Hauer; Robert MacColl; Liming Changchien; Frank Maley
Significance of mutations on the structural perturbation of thymidylate synthase: implications for their involvement in subunit exchange.
Yuanzheng Zhang; Frank Maley; Gladys F Maley; Garry Duncan; David D Dunigan; James L Van Etten
Chloroviruses encode a bifunctional dCMP-dCTP deaminase that produces two key intermediates in dTTP formation.
J Cieśla; Elzbieta Jagielska; T Skopiński; M Dabrowska; Frank Maley; Wojciech Rode
Binding and repression of translation of the cognate mRNA by Trichinella spiralis thymidylate synthase differ from the corresponding interactions of the human enzyme.

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All Publications

2007: Ruth L Saxl; Gladys F Maley; Charles R Hauer; Robert MacColl; Liming Changchien; Frank Maley
Significance of mutations on the structural perturbation of thymidylate synthase: implications for their involvement in subunit exchange.
Protein science : a publication of the Protein Society 2007;16(7):1439-48.
2007: Yuanzheng Zhang; Frank Maley; Gladys F Maley; Garry Duncan; David D Dunigan; James L Van Etten
Chloroviruses encode a bifunctional dCMP-dCTP deaminase that produces two key intermediates in dTTP formation.
Journal of virology 2007;81(14):7662-71.
2007: J Cieśla; Elzbieta Jagielska; T Skopiński; M Dabrowska; Frank Maley; Wojciech Rode
Binding and repression of translation of the cognate mRNA by Trichinella spiralis thymidylate synthase differ from the corresponding interactions of the human enzyme.
The Biochemical journal 2007;402(3):601.
2006: Sue A Roberts; David C Hyatt; Jerry E Honts; Liming Changchien; Gladys F Maley; Frank Maley; William R Montfort
Structure of the Y94F mutant of Escherichia coli thymidylate synthase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 9):840-3.
2006: Rogerio Sotelo-Mundo; Liming Changchien; Frank Maley; William R Montfort
Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.
Journal of biochemical and molecular toxicology 2006;20(2):88-92.
2005: Joanna Cieśla; Elzbieta Jagielska; Tomasz Skopiński; Magdalena D Abrowska; Frank Maley; Wojciech Rode
Binding and repression of translation of the cognate mRNA by Trichinella spiralis thymidylate synthase differ from the corresponding interactions of the human enzyme.
The Biochemical journal 2005;390(Pt 3):681-8.
2004: Rami Almog; Frank Maley; Gladys F Maley; Robert MacColl; Patrick Van Roey
Three-dimensional structure of the R115E mutant of T4-bacteriophage 2'-deoxycytidylate deaminase.
Biochemistry 2004;43(43):13715-23.
2004: Deborah K West; Donald C Porter; Ruth L Saxl; Frank Maley
A trojan horse approach for silencing thymidylate synthase.
Biochemistry 2004;43(28):9177-84.
2003: Xiukun Lin; Jun Liu; Frank Maley; Edward Chu
Role of cysteine amino acid residues on the RNA binding activity of human thymidylate synthase.
Nucleic acids research 2003;31(16):4882-7.
2003: Ruth L Saxl; James Reston; Zhe Nie; Thomas I Kalman; Frank Maley
Modification of Escherichia coli thymidylate synthase at tyrosine-94 by 5-imidazolylpropynyl-2'-deoxyuridine 5'-monophosphate.
Biochemistry 2003;42(15):4544-51.
2002: Eric F Johnson; Wolfgang Hinz; Chloé E Atreya; Frank Maley; Karen S Anderson
Mechanistic characterization of Toxoplasma gondii thymidylate synthase (TS-DHFR)-dihydrofolate reductase. Evidence for a TS intermediate and TS half-sites reactivity.
The Journal of biological chemistry 2002;277(45):43126-36.
2001: Ruth L Saxl; Liming Changchien; L W Hardy; Frank Maley
Parameters affecting the restoration of activity to inactive mutants of thymidylate synthase via subunit exchange: further evidence that thymidylate synthase is a half-of-the-sites activity enzyme.
Biochemistry 2001;40(17):5275-82.
2001: R Almog; CA Waddling; Frank Maley; Gladys F Maley; Patrick Van Roey
Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
Protein science : a publication of the Protein Society 2001;10(5):988-96.
2000: Xiukun Lin; N Mizunuma; T Chen; Sitki Copur; Gladys F Maley; Jun Liu; Frank Maley; Edward Chu
In vitro selection of an RNA sequence that interacts with high affinity with thymidylate synthase.
Nucleic acids research 2000;28(21):4266-74.
2000: Leslie A Parsels; M P Kowalski; L M Wagner; Joshua D Parsels; Frank Maley; Jonathan Maybaum
Escherichia coli thymidylate synthase expression protects human cells from the cytotoxic effects of 5-fluorodeoxyuridine more effectively than human thymidylate synthase overexpression.
Cancer gene therapy 2000;7(8):1179-87.
2000: Liming Changchien; A Garibian; Verna Frasca; A Lobo; Gladys F Maley; Frank Maley
High-level expression of Escherichia coli and Bacillus subtilis thymidylate synthases.
Protein expression and purification 2000;19(2):265-70.
2000: R G Keefe; Gladys F Maley; Ruth L Saxl; Frank Maley
A T4-phage deoxycytidylate deaminase mutant that no longer requires deoxycytidine 5'-triphosphate for activation.
The Journal of biological chemistry 2000;275(17):12598-602.
2000: Xiukun Lin; Leslie A Parsels; Donna Voeller; Carmen J Allegra; Gladys F Maley; Frank Maley; Edward Chu
Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA.
Nucleic acids research 2000;28(6):1381-9.
1999: A Reddy; B S Gibbs; Y L Liu; James K Coward; Liming Changchien; Frank Maley
Glycosylation of the overlapping sequons in yeast external invertase: effect of amino acid variation on site selectivity in vivo and in vitro.
Glycobiology 1999;9(6):547-55.
1999: Jingfang Ju; J Pedersen-Lane; Frank Maley; Edward Chu
Regulation of p53 expression by thymidylate synthase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3769-74.
1999: K M Fox; Frank Maley; A Garibian; Liming Changchien; Patrick Van Roey
Crystal structure of thymidylate synthase A from Bacillus subtilis.
Protein science : a publication of the Protein Society 1999;8(3):538-44.
1999: Edward Chu; Sitki Copur; Jingfang Ju; Tian-min Chen; Samir N Khleif; Donna Voeller; N Mizunuma; M Patel; Gladys F Maley; Frank Maley; Carmen J Allegra
Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complex.
Molecular and cellular biology 1999;19(2):1582-94.
1999: Rogerio Sotelo-Mundo; Joanna Ciesla; Jolanta M Dzik; Wojciech Rode; Frank Maley; Gladys F Maley; L W Hardy; William R Montfort
Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.
Biochemistry 1999;38(3):1087-94.
1998: A P Lobo; M G Nair; Liming Changchien; Andrzej Weichsel; William R Montfort; Frank Maley
Mode of action of site-directed irreversible folate analogue inhibitors of thymidylate synthase.
Biochemistry 1998;37(13):4535-42.
1997: Pavel Strop; Liming Changchien; Frank Maley; William R Montfort
Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu.
Protein science : a publication of the Protein Society 1997;6(12):2504-11.
1997: J Pedersen-Lane; Gladys F Maley; Edward Chu; Frank Maley
High-level expression of human thymidylate synthase.
Protein expression and purification 1997;10(2):256-62.
1997: William A Samsonoff; J Reston; M McKee; B O'Connor; J Galivan; Gladys F Maley; Frank Maley
Intracellular location of thymidylate synthase and its state of phosphorylation.
The Journal of biological chemistry 1997;272(20):13281-5.
1997: D C Hyatt; Frank Maley; William R Montfort
Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate.
Biochemistry 1997;36(15):4585-94.
1996: K M McGaughey; L J Wheeler; J T Moore; Gladys F Maley; Frank Maley; Christopher K Mathews
Protein-protein interactions involving T4 phage-coded deoxycytidylate deaminase and thymidylate synthase.
The Journal of biological chemistry 1996;271(38):23037-42.
1996: C H Chen; R A Davis; Frank Maley
Thermodynamic stabilization of nucleotide binding to thymidylate synthase by a potent benzoquinazoline folate analogue inhibitor.
Biochemistry 1996;35(26):8786-93.
1996: A Reddy; Frank Maley
Studies on identifying the catalytic role of Glu-204 in the active site of yeast invertase.
The Journal of biological chemistry 1996;271(24):13953-7.
1995: K X Weiner; J Ciesla; A B Jaffe; R Ketring; Frank Maley; Gladys F Maley
Chromosomal location and structural organization of the human deoxycytidylate deaminase gene.
The Journal of biological chemistry 1995;270(32):18727-9.
1995: Andrzej Weichsel; William R Montfort; J Cieśla; Frank Maley
Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3493-7.
1995: J Cieśla; K X Weiner; R S Weiner; J T Reston; Gladys F Maley; Frank Maley
Isolation and expression of rat thymidylate synthase cDNA: phylogenetic comparison with human and mouse thymidylate synthases.
Biochimica et biophysica acta 1995;1261(2):233-42.
1995: X Chen; Christopher K Mathews; L J Wheeler; Gladys F Maley; Frank Maley; DH Coombs
An immunoblot assay reveals that bacteriophage T4 thymidylate synthase and dihydrofolate reductase are not virion proteins.
Journal of virology 1995;69(4):2119-25.
1995: D M Voeller; Liming Changchien; Gladys F Maley; Frank Maley; T Takechi; R E Turner; William R Montfort; Carmen J Allegra; Edward Chu
Characterization of a specific interaction between Escherichia coli thymidylate synthase and Escherichia coli thymidylate synthase mRNA.
Nucleic acids research 1995;23(5):869-75.
1995: Frank Maley; J Pedersen-Lane; L Changchien
Complete restoration of activity to inactive mutants of Escherichia coli thymidylate synthase: evidence that E. coli thymidylate synthase is a half-the-sites activity enzyme.
Biochemistry 1995;34(5):1469-74.
1995: Edward Chu; T Takechi; K L Jones; D M Voeller; Sitki Copur; Gladys F Maley; Frank Maley; S Segal; Carmen J Allegra
Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro.
Molecular and cellular biology 1995;15(1):179-85.
1994: Janet S Finer-Moore; Gladys F Maley; Frank Maley; William R Montfort; Robert M Stroud
Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex.
Biochemistry 1994;33(51):15459-68.
1994: Edward Chu; D M Voeller; Paul F Morrison; K L Jones; T Takechi; Gladys F Maley; Frank Maley; Carmen J Allegra
The effect of reducing reagents on binding of thymidylate synthase protein to thymidylate synthase messenger RNA.
The Journal of biological chemistry 1994;269(32):20289-93.
1994: J T Moore; J M Cieśla; Liming Changchien; Gladys F Maley; Frank Maley
Identification of a site necessary for allosteric regulation in T4-phage deoxycytidylate deaminase.
Biochemistry 1994;33(8):2104-12.
1994: E B Fauman; Earl Rutenber; Gladys F Maley; Frank Maley; Robert M Stroud
Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A.
Biochemistry 1994;33(6):1502-11.
1994: Edward Chu; D M Voeller; K L Jones; T Takechi; Gladys F Maley; Frank Maley; S Segal; Carmen J Allegra
Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells.
Molecular and cellular biology 1994;14(1):207-13.
1993: P J Greene; Frank Maley; J Pedersen-Lane; Daniel V Santi
Catalytically active cross-species heterodimers of thymidylate synthase.
Biochemistry 1993;32(39):10283-8.
1993: K X Weiner; R S Weiner; Frank Maley; Gladys F Maley
Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli.
The Journal of biological chemistry 1993;268(17):12983-9.
1993: J T Moore; A Uppal; Frank Maley; Gladys F Maley
Overcoming inclusion body formation in a high-level expression system.
Protein expression and purification 1993;4(2):160-3.
1993: Gladys F Maley; A P Lobo; Frank Maley
Properties of an affinity-column-purified human deoxycytidylate deaminase.
Biochimica et biophysica acta 1993;1162(1-2):161-70.
1993: J T Moore; Ruth E Silversmith; Gladys F Maley; Frank Maley
T4-phage deoxycytidylate deaminase is a metalloprotein containing two zinc atoms per subunit.
The Journal of biological chemistry 1993;268(4):2288-91.
1993: J T Moore; Gladys F Maley; Frank Maley
A modified unique site elimination plasmid mutagenesis procedure utilizing standard calcium chloride transformations.
Analytical biochemistry 1993;208(2):402-3.
1993: Edward Chu; D Voeller; David M Koeller; J C Drake; Chris H Takimoto; Gladys F Maley; Frank Maley; Carmen J Allegra
Identification of an RNA binding site for human thymidylate synthase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):517-21.
1993: A Reddy; Frank Maley
Dithiothreitol improves the efficiency of yeast transformation.
Analytical biochemistry 1993;208(1):211-2.
1991: F K Chu; Frank Maley; A M Wang; J Pedersen-Lane; Gladys F Maley
Purification and substrate specificity of a T4 phage intron-encoded endonuclease.
Nucleic acids research 1991;19(24):6863-9.
1991: Robert B Trimble; P H Atkinson; J F Tschopp; R R Townsend; Frank Maley
Structure of oligosaccharides on Saccharomyces SUC2 invertase secreted by the methylotrophic yeast Pichia pastoris.
The Journal of biological chemistry 1991;266(34):22807-17.
1990: L LaPat-Polasko; Gladys F Maley; Frank Maley
Properties of bacteriophage T4 thymidylate synthase following mutagenic changes in the active site and folate binding region.
Biochemistry 1990;29(41):9561-72.
1990: William R Montfort; K M Perry; E B Fauman; Janet S Finer-Moore; Gladys F Maley; L Hardy; Frank Maley; Robert M Stroud
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.
Biochemistry 1990;29(30):6964-77.
1990: V A Reddy; Frank Maley
Identification of an active-site residue in yeast invertase by affinity labeling and site-directed mutagenesis.
The Journal of biological chemistry 1990;265(19):10817-20.
1990: M S Rhee; M Balinska; Marlene A Bunni; David G Priest; Gladys F Maley; Frank Maley; John Galivan
Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells.
Cancer research 1990;50(13):3979-84.
1990: Frank Maley; F K Chu; Gladys F Maley
Intron-associated splicing reactions in bacteriophage T4.
Molecular microbiology 1990;4(6):867-71.
1990: F K Chu; Gladys F Maley; J Pedersen-Lane; A M Wang; Frank Maley
Characterization of the restriction site of a prokaryotic intron-encoded endonuclease.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3574-8.
1990: AL Tarentino; G Quinones; A Trumble; Liming Changchien; B Duceman; Frank Maley; TH Plummer
Molecular cloning and amino acid sequence of peptide-N4-(N-acetyl-beta-D-glucosaminyl)asparagine amidase from flavobacterium meningosepticum.
The Journal of biological chemistry 1990;265(12):6961-6.
1990: A V Reddy; Robert MacColl; Frank Maley
Effect of oligosaccharides and chloride on the oligomeric structures of external, internal, and deglycosylated invertase.
Biochemistry 1990;29(10):2482-7.
1990: Gladys F Maley; B W Duceman; A M Wang; J Martinez; Frank Maley
Cloning, sequence analysis, and expression of the bacteriophage T4 cd gene.
The Journal of biological chemistry 1990;265(1):47-51.
1990: Frank Maley; Gladys F Maley
A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase.
Progress in nucleic acid research and molecular biology 1990;39():49-80.
1990: K M Perry; E B Fauman; Janet S Finer-Moore; William R Montfort; Gladys F Maley; Frank Maley; Robert M Stroud
Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases.
Proteins 1990;8(4):315-33.
1989: Frank Maley; Robert B Trimble; AL Tarentino; TH Plummer
Characterization of glycoproteins and their associated oligosaccharides through the use of endoglycosidases.
Analytical biochemistry 1989;180(2):195-204.
1989: D K West; Liming Changchien; Gladys F Maley; Frank Maley
Evidence that the intron open reading frame of the phage T4 td gene encodes a specific endonuclease.
The Journal of biological chemistry 1989;264(18):10343-6.
1989: Gladys F Maley; Frank Maley
An anomaly in the active site region of thymidylate synthase.
Advances in enzyme regulation 1989;29():181-7.
1988: Gladys F Maley; Frank Maley
Properties of a defined mutant of Escherichia coli thymidylate synthase.
The Journal of biological chemistry 1988;263(16):7620-7.
1988: V A Reddy; R S Johnson; K Biemann; R S Williams; F D Ziegler; Robert B Trimble; Frank Maley
Characterization of the glycosylation sites in yeast external invertase. I. N-linked oligosaccharide content of the individual sequons.
The Journal of biological chemistry 1988;263(15):6978-85.
1988: F D Ziegler; Frank Maley; Robert B Trimble
Characterization of the glycosylation sites in yeast external invertase. II. Location of the endo-beta-N-acetylglucosaminidase H-resistant sequons.
The Journal of biological chemistry 1988;263(15):6986-92.
1988: F K Chu; Gladys F Maley; Frank Maley
RNA splicing in the T-even bacteriophage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(3):216-23.
1987: F K Chu; Frank Maley; J Martinez; Gladys F Maley
Interrupted thymidylate synthase gene of bacteriophages T2 and T6 and other potential self-splicing introns in the T-even bacteriophages.
Journal of bacteriology 1987;169(9):4368-75.
1987: F K Chu; Gladys F Maley; Frank Maley
Mechanism and requirements of in vitro RNA splicing of the primary transcript from the T4 bacteriophage thymidylate synthase gene.
Biochemistry 1987;26(11):3050-7.
1987: F K Chu; Gladys F Maley; A M Wang; Frank Maley
Localization of the T4 phage ribonucleotide reductase B1 subunit gene and the nucleotide sequence of its upstream and 5' coding regions.
Gene 1987;57(1):143-8.
1987: Robert B Trimble; R J Trumbly; Frank Maley
Endo-beta-N-acetylglucosaminidase H from Streptomyces plicatus.
Methods in enzymology 1987;138():763-70.
1986: D K West; Marlene Belfort; Gladys F Maley; Frank Maley
Cloning and expression of an intron-deleted phage T4 td gene.
The Journal of biological chemistry 1986;261(29):13446-50.
1986: Frank Maley; Gladys F Maley; D K West; Marlene Belfort; F K Chu
RNA processing in a structural gene from bacteriophage T4.
Biochemical Society transactions 1986;14(5):813-5.
1986: Robert B Trimble; P H Atkinson; AL Tarentino; TH Plummer; Frank Maley; K B Tomer
Transfer of glycerol by Endo-beta-N-acetylglucosaminidase F to oligosaccharides during chitobiose core cleavage.
The Journal of biological chemistry 1986;261(26):12000-5.
1986: K Ehrenman; J Pedersen-Lane; D West; R Herman; Frank Maley; Marlene Belfort
Processing of phage T4 td-encoded RNA is analogous to the eukaryotic group I splicing pathway.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(16):5875-9.
1986: F K Chu; Gladys F Maley; D K West; Marlene Belfort; Frank Maley
Characterization of the intron in the phage T4 thymidylate synthase gene and evidence for its self-excision from the primary transcript.
Cell 1986;45(2):157-66.
1986: Marlene Belfort; J Pedersen-Lane; K Ehrenman; F K Chu; Gladys F Maley; Frank Maley; D S McPheeters; L Gold
RNA splicing and in vivo expression of the intron-containing td gene of bacteriophage T4.
Gene 1986;41(1):93-102.
1985: R S Williams; R J Trumbly; R MacColl; Robert B Trimble; Frank Maley
Comparative properties of amplified external and internal invertase from the yeast SUC2 gene.
The Journal of biological chemistry 1985;260(24):13334-41.
1985: F K Chu; Gladys F Maley; Marlene Belfort; Frank Maley
In vitro expression of the intron-containing gene for T4 phage thymidylate synthase.
The Journal of biological chemistry 1985;260(19):10680-8.
1985: Marlene Belfort; J Pedersen-Lane; D West; K Ehrenman; Gladys F Maley; F Chu; Frank Maley
Processing of the intron-containing thymidylate synthase (td) gene of phage T4 is at the RNA level.
Cell 1985;41(2):375-82.
1985: R J Trumbly; P W Robbins; M Belfort; F D Ziegler; Frank Maley; Robert B Trimble
Amplified expression of streptomyces endo-beta-N-acetylglucosaminidase H in Escherichia coli and characterization of the enzyme product.
The Journal of biological chemistry 1985;260(9):5683-90.
1984: F K Chu; Gladys F Maley; Frank Maley; Marlene Belfort
Intervening sequence in the thymidylate synthase gene of bacteriophage T4.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(10):3049-53.
1983: Marlene Belfort; Gladys F Maley; J Pedersen-Lane; Frank Maley
Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(16):4914-8.
1982: J C Byrd; AL Tarentino; Frank Maley; P H Atkinson; Robert B Trimble
Glycoprotein synthesis in yeast. Identification of Man8GlcNAc2 as an essential intermediate in oligosaccharide processing.
The Journal of biological chemistry 1982;257(24):14657-66.