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Jaroslav Malina

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Jaroslav Malina; Giovanni Natile; Olga Novakova; Viktor Brabec
The thermodynamics of translesion DNA synthesis past major adducts of enantiomeric analogues of antitumor cisplatin.
Hana Kostrhunova; Jaroslav Malina; Tereza Muchova; Amanda J Pickard; Matthew L Rohlfing; Jana Stepankova; Marie Vojtiskova; Ulrich Bierbach; Jana Kasparkova; Viktor Brabec
Replacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair.
Jana Stepankova; Martin Studenovsky; Karel Ulbrich; Jana Kasparkova; Barbora Liskova; Jaroslav Malina; Olga Novakova; Viktor Brabec
DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin.

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All Publications

2012: Jaroslav Malina; Giovanni Natile; Olga Novakova; Viktor Brabec
The thermodynamics of translesion DNA synthesis past major adducts of enantiomeric analogues of antitumor cisplatin.
Chemistry, an Asian journal 2012;7(5):1026-31.
2011: Hana Kostrhunova; Jaroslav Malina; Tereza Muchova; Amanda J Pickard; Matthew L Rohlfing; Jana Stepankova; Marie Vojtiskova; Ulrich Bierbach; Jana Kasparkova; Viktor Brabec
Replacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair.
Molecular pharmaceutics 2011;8(5):1941-54.
2011: Jana Stepankova; Martin Studenovsky; Karel Ulbrich; Jana Kasparkova; Barbora Liskova; Jaroslav Malina; Olga Novakova; Viktor Brabec
DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin.
Biochemical pharmacology 2011;82(3):227-35.
2011: Jaroslav Malina; Nicholas P Farrell; Viktor Brabec
DNA interstrand cross-links of an antitumor trinuclear platinum(II) complex: thermodynamic analysis and chemical probing.
Chemistry, an Asian journal 2011;6(6):1566-74.
2011: Jaroslav Malina; Jana Kasparkova; Nicholas Farrell; Viktor Brabec
Walking of antitumor bifunctional trinuclear PtII complex on double-helical DNA.
Nucleic acids research 2011;39(2):720-8.
2010: Olga Novakova; Jaroslav Malina; Tereza Suchankova; Jana Kasparkova; Tijana Bugarcic; Peter J Sadler; Viktor Brabec
Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru(II) complexes containing terphenyl arenes.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(19):5744-54.
2009: Jaroslav Malina; Oldrich Vrana; Viktor Brabec
Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional PtII complexes.
Nucleic acids research 2009;37(16):5432-42.
2009: Olga Nováková; Jaroslav Malina; Jana Kaspárková; Anna Halámiková; Vladan Bernard; Francesco P Intini; Giovanni Natile; Viktor Brabec
Energetics, conformation, and recognition of DNA duplexes modified by methylated analogues of [PtCl(dien)]+.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(25):6211-21.
2008: Jaroslav Malina; Michael J Hannon; Viktor Brabec
DNA binding of dinuclear iron(II) metallosupramolecular cylinders. DNA unwinding and sequence preference.
Nucleic acids research 2008;36(11):3630-8.
2008: Jaroslav Malina; Michael J Hannon; Viktor Brabec
Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(33):10408-14.
2007: Jaroslav Malina; Olga Novakova; Marie Vojtiskova; Giovanni Natile; Viktor Brabec
Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog.
Biophysical journal 2007;93(11):3950-62.
2007: Jemma C Peberdy; Jaroslav Malina; Syma Khalid; Michael J Hannon; Alison Rodger
Influence of surface shape on DNA binding of bimetallo helicates.
Journal of inorganic biochemistry 2007;101(11-12):1937-45.
2007: Jaroslav Malina; Michael J Hannon; Viktor Brabec
Recognition of DNA three-way junctions by metallosupramolecular cylinders: gel electrophoresis studies.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(14):3871-7.
2006: Laura J Childs; Jaroslav Malina; Britt Elin Rolfsnes; Mirela Pascu; Maria J Prieto; Mark J Broome; P Mark Rodger; Einar Sletten; Virtudes Moreno; Alison Rodger; Michael J Hannon
A DNA-binding copper(I) metallosupramolecular cylinder that acts as an artificial nuclease.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(18):4919-27.
2006: Viktor Brabec; Kristýna Stehlíková; Jaroslav Malina; Marie Vojtiísková; Jana Kaspárková
Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A.
Archives of biochemistry and biophysics 2006;446(1):1-10.
2005: Jaroslav Malina; Marie Vojtiskova; Viktor Brabec; Connie I Diakos; Trevor W Hambley
DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins.
Biochemical and biophysical research communications 2005;332(4):1034-41.
2005: Olivier Delalande; Jaroslav Malina; Viktor Brabec; Jirí Kozelka
Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent.
Biophysical journal 2005;88(6):4159-69.
2005: Carsten Uerpmann; Jaroslav Malina; Mirela Pascu; Guy J Clarkson; Virtudes Moreno; Alison Rodger; Anna Grandas; Michael J Hannon
Design and DNA binding of an extended triple-stranded metallo-supramolecular cylinder.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(6):1750-6.
2004: Miriam Kloster; Hana Kostrhunova; Renata Zaludova; Jaroslav Malina; Jana Kasparkova; Viktor Brabec; Nicholas Farrell
Trifunctional dinuclear platinum complexes as DNA-protein cross-linking agents.
Biochemistry 2004;43(24):7776-86.
2003: Olga Novakova; Jana Kasparkova; Jaroslav Malina; Giovanni Natile; Viktor Brabec
DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes.
Nucleic acids research 2003;31(22):6450-60.
2002: Michele Benedetti; Jaroslav Malina; Jana Kasparkova; Viktor Brabec; Giovanni Natile
Chiral discrimination in platinum anticancer drugs.
Environmental health perspectives 2002;110 Suppl 5():779-82.
2002: Jaroslav Malina; Jana Kasparkova; Giovanni Natile; Viktor Brabec
Recognition of major DNA adducts of enantiomeric cisplatin analogs by HMG box proteins and nucleotide excision repair of these adducts.
Chemistry & biology 2002;9(5):629-38.
2001: Jaroslav Malina; Olga Novakova; B K Keppler; E Alessio; Viktor Brabec
Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(4):435-45.
2000: Jaroslav Malina; Ctirad Hofr; L Maresca; Giovanni Natile; Viktor Brabec
DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands.
Biophysical journal 2000;78(4):2008-21.