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Richard Malley

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Alan Basset; Cyril Benes; Andrew Camilli; Douglas T Golenbock; Muriel Herd; Sabina Sayeed; Claudette Thompson; Fan Zhang; Richard Malley
Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein.
Lise E Nigrovic; Richard Malley; Nathan Kuppermann
Meta-analysis of bacterial meningitis score validation studies.
Kristin L Moffitt; Daniel M Weinberger; Puja Yadav; Porter W Anderson; Richard Malley
Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine.

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All Publications

2013: Alan Basset; Cyril Benes; Andrew Camilli; Douglas T Golenbock; Muriel Herd; Sabina Sayeed; Claudette Thompson; Fan Zhang; Richard Malley
Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein.
The Journal of biological chemistry 2013;288(4):2665-75.
2012: Lise E Nigrovic; Richard Malley; Nathan Kuppermann
Meta-analysis of bacterial meningitis score validation studies.
Archives of disease in childhood 2012;97(9):799-805.
2012: Kristin L Moffitt; Daniel M Weinberger; Puja Yadav; Porter W Anderson; Richard Malley
Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine.
Vaccine 2012;30(29):4316-22.
2012: Ying-Jie Lu; Porter W Anderson; Sabina Sayeed; Shousun Szu; Claudette M Thompson; Fan Zhang; Richard Malley
A bivalent vaccine to protect against Streptococcus pneumoniae and Salmonella typhi.
Vaccine 2012;30(23):3405-12.
2012: Richard Malley; Porter W Anderson
Serotype-independent pneumococcal experimental vaccines that induce cellular as well as humoral immunity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(10):3623-7.
2012: Yuan Li; Richard Malley; Claudette M Thompson; Krzysztof Trzciński; Nicholas Croucher; Jessica B Flechtner; Christopher B Ford; Todd Gierahn; Paulo Gouveia; Marc Lipsitch
Distinct effects on diversifying selection by two mechanisms of immunity against Streptococcus pneumoniae.
PLoS pathogens 2012;8(11):e1002989.
2012: Gili Regev-Yochay; Yulia Roytman; Bracha Shainberg; Miriam Varon; Arnona Ziv; Izzeldin Abullaish; Abedallah Elhamdany; Aviva Goral; Richard Malley; Galia Rahav; Meir Raz
Streptococcus pneumoniae carriage in the Gaza strip.
PloS one 2012;7(4):e35061.
2011: Daniel M Weinberger; Richard Malley; Marc Lipsitch
Serotype replacement in disease after pneumococcal vaccination.
Lancet 2011;378(9807):1962-73.
2011: Alan Basset; Elizabeth Boush; Simon L Dove; Sabina Sayeed; Keith Holte Turner; Richard Malley
Expression of the type 1 pneumococcal pilus is bistable and negatively regulated by the structural component RrgA.
Infection and immunity 2011;79(8):2974-83.
2011: Kristin L Moffitt; Richard Malley
Next generation pneumococcal vaccines.
Current opinion in immunology 2011;23(3):407-13.
2011: Kristin L Moffitt; Todd M Gierahn; Ying-jie Lu; Paulo Gouveia; Mark Alderson; Jessica Flechtner; Darren E Higgins; Richard Malley
T(H)17-based vaccine design for prevention of Streptococcus pneumoniae colonization.
Cell host & microbe 2011;9(2):158-65.
2010: Lise E Nigrovic; Richard Malley; Dewesh Agrawal; Nathan Kuppermann
Low risk of bacterial meningitis in children with a positive enteroviral polymerase chain reaction test result.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010;51(10):1221-2.
2010: Ying-Jie Lu; Luciana C C Leite; Viviane Maimoni Gonçalves; Waldely de Oliveira Dias; Celia Liberman; Fernando Fratelli; Mark R Alderson; Andrea Tate; Jean-François Maisonneuve; George Robertson; Rita Graca; Sabina Sayeed; Claudette M Thompson; Porter Anderson; Richard Malley
GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis.
Vaccine 2010;28(47):7468-75.
2010: Gili Regev-Yochay; William P Hanage; Krzysztof Trzcinski; Sheryl L Rifas-Shiman; Grace Lee; Andrew Bessolo; Susan S Huang; Stephen I Pelton; Alexander J McAdam; Jonathan A Finkelstein; Marc Lipsitch; Richard Malley
Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA.
Vaccine 2010;28(30):4842-6.
2010: Ying-Jie Lu; Puja Yadav; John Clements; Sophie Forte; Amit Srivastava; Claudette M Thompson; Robert Seid; Jee Look; Mark Alderson; Andrea Tate; Jean-François Maisonneuve; George Robertson; Porter W Anderson; Richard Malley
Options for inactivation, adjuvant, and route of topical administration of a killed, unencapsulated pneumococcal whole-cell vaccine.
Clinical and vaccine immunology : CVI 2010;17(6):1005-12.
2010: Richard Malley
Antibody and cell-mediated immunity to Streptococcus pneumoniae: implications for vaccine development.
Journal of molecular medicine (Berlin, Germany) 2010;88(2):135-42.
2010: D Bogaert; Claudette M Thompson; Krzysztof Trzcinski; Richard Malley; Marc Lipsitch
The role of complement in innate and adaptive immunity to pneumococcal colonization and sepsis in a murine model.
Vaccine 2010;28(3):681-5.
2009: Ying-Jie Lu; Ian Chr Skovsted; Claudette M Thompson; Porter W Anderson; Richard Malley
Mechanisms in the serotype-independent pneumococcal immunity induced in mice by intranasal vaccination with the cell wall polysaccharide.
Microbial pathogenesis 2009;47(3):177-82.
2009: Daniel M Weinberger; Krzysztof Trzciński; Ying-Jie Lu; Debby Bogaert; Aaron Brandes; James E Galagan; Porter W Anderson; Richard Malley; Marc Lipsitch
Pneumococcal capsular polysaccharide structure predicts serotype prevalence.
PLoS pathogens 2009;5(6):e1000476.
2009: Ying-Jie Lu; Sophie Forte; Claudette M Thompson; Porter W Anderson; Richard Malley
Protection against Pneumococcal colonization and fatal pneumonia by a trivalent conjugate of a fusion protein with the cell wall polysaccharide.
Infection and immunity 2009;77(5):2076-83.
2009: Gili Regev-Yochay; Marc Lipsitch; Alan Basset; Ethan Rubinstein; Ron Dagan; Meir Raz; Richard Malley
The pneumococcal pilus predicts the absence of Staphylococcus aureus co-colonization in pneumococcal carriers.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009;48(6):760-3.
2009: Lise E Nigrovic; Richard Malley; Nathan Kuppermann
Cerebrospinal fluid pleocytosis in children in the era of bacterial conjugate vaccines: distinguishing the child with bacterial and aseptic meningitis.
Pediatric emergency care 2009;25(2):112-7; quiz 118-20.
2009: Ward P Myers; Andrea P Myers; Janet Cox-Singh; Hui C Lau; Benny Mokuai; Richard Malley
Micro-geographic risk factors for malarial infection.
Malaria journal 2009;8():27.
2008: Lise E Nigrovic; Nathan Kuppermann; Richard Malley
Children with bacterial meningitis presenting to the emergency department during the pneumococcal conjugate vaccine era.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2008;15(6):522-8.
2008: Daniel M Weinberger; Ron Dagan; Noga Givon-Lavi; Gili Regev-Yochay; Richard Malley; Marc Lipsitch
Epidemiologic evidence for serotype-specific acquired immunity to pneumococcal carriage.
The Journal of infectious diseases 2008;197(11):1511-8.
2008: Krzysztof Trzciński; Claudette M Thompson; Amit Srivastava; Alan Basset; Richard Malley; Marc Lipsitch
Protection against nasopharyngeal colonization by Streptococcus pneumoniae is mediated by antigen-specific CD4+ T cells.
Infection and immunity 2008;76(6):2678-84.
2008: Gili Regev-Yochay; Richard Malley; Ethan Rubinstein; Meir Raz; Ron Dagan; Marc Lipsitch
In vitro bactericidal activity of Streptococcus pneumoniae and bactericidal susceptibility of Staphylococcus aureus strains isolated from cocolonized versus noncocolonized children.
Journal of clinical microbiology 2008;46(2):747-9.
2008: Ying-Jie Lu; Jane Gross; Debby Bogaert; Adam Finn; Linda Bagrade; Qibo Zhang; Jay K Kolls; Amit Srivastava; Anna Lundgren; Sophie Forte; Claudette M Thompson; Kathleen F Harney; Porter W Anderson; Marc Lipsitch; Richard Malley
Interleukin-17A mediates acquired immunity to pneumococcal colonization.
PLoS pathogens 2008;4(9):e1000159.
2007: Alan Basset; Claudette M Thompson; Susan Kay Hollingshead; David E Briles; Edwin W Ades; Marc Lipsitch; Richard Malley
Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins.
Infection and immunity 2007;75(11):5460-4.
2007: Richard Malley; Marc Lipsitch; Debby Bogaert; Claudette M Thompson; Peter Hermans; A Claire Watkins; Sanjay Sethi; Timothy F Murphy
Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease.
The Journal of infectious diseases 2007;196(6):928-35.
2007: Gili Regev-Yochay; Krzysztof Trzcinski; Claudette M Thompson; Marc Lipsitch; Richard Malley
SpxB is a suicide gene of Streptococcus pneumoniae and confers a selective advantage in an in vivo competitive colonization model.
Journal of bacteriology 2007;189(18):6532-9.
2007: Alan Basset; Krzysztof Trzcinski; Christina Hermos; Katherine L O'Brien; Raymond Reid; Mathuram Santosham; Alexander J McAdam; Marc Lipsitch; Richard Malley
Association of the pneumococcal pilus with certain capsular serotypes but not with increased virulence.
Journal of clinical microbiology 2007;45(6):1684-9.
2007: Lise E Nigrovic; Nathan Kuppermann; Charles G Macias; Christopher R Cannavino; Donna M Moro-Sutherland; Robert D Schremmer; Sandra H Schwab; Dewesh Agrawal; Karim M Mansour; Jonathan E Bennett; Yiannis L Katsogridakis; Michael M Mohseni; Blake Bulloch; Dale W Steele; Ron L Kaplan; Martin I Herman; Subhankar Bandyopadhyay; Peter S Dayan; Uyen T Truong; Vincent J Wang; Bema K Bonsu; Jennifer L Chapman; John T Kanegaye; Richard Malley
Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis.
JAMA : the journal of the American Medical Association 2007;297(1):52-60.
2007: Amit Srivastava; Heather Casey; Nathaniel Johnson; Ofer Levy; Richard Malley
Recombinant bactericidal/permeability-increasing protein rBPI21 protects against pneumococcal disease.
Infection and immunity 2007;75(1):342-9.
2006: Gili Regev-Yochay; Krzysztof Trzcinski; Claudette M Thompson; Richard Malley; Marc Lipsitch
Interference between Streptococcus pneumoniae and Staphylococcus aureus: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae.
Journal of bacteriology 2006;188(13):4996-5001.
2006: Richard Malley; Amit Srivastava; Marc Lipsitch; Claudette M Thompson; Claire Watkins; Arthur O Tzianabos; Porter W Anderson
Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide.
Infection and immunity 2006;74(4):2187-95.
2006: Sybille Kenzel; Giuseppe Mancuso; Richard Malley; Giuseppe Teti; Douglas T Golenbock; Philipp Henneke
c-Jun kinase is a critical signaling molecule in a neonatal model of group B streptococcal sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3181-8.
2005: Krzysztof Trzcinski; Claudette Thompson; Richard Malley; Marc Lipsitch
Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model.
Infection and immunity 2005;73(10):7043-6.
2005: Amit Srivastava; Philipp Henneke; Alberto Visintin; Sarah C Morse; Victoria Martin; Claire Watkins; James C Paton; Michael R Wessels; Douglas T Golenbock; Richard Malley
The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease.
Infection and immunity 2005;73(10):6479-87.
2005: Richard Malley; Krzysztof Trzcinski; Amit Srivastava; Claudette M Thompson; Porter W Anderson; Marc Lipsitch
CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(13):4848-53.
2005: Marc Lipsitch; Cynthia G Whitney; Elizabeth R Zell; Tarja Kaijalainen; Ron Dagan; Richard Malley
Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease?
PLoS medicine 2005;2(1):e15.
2004: Lise E Nigrovic; Nathan Kuppermann; Alexander J McAdam; Richard Malley
Cerebrospinal latex agglutination fails to contribute to the microbiologic diagnosis of pretreated children with meningitis.
The Pediatric infectious disease journal 2004;23(8):786-8.
2004: Richard Malley; Sarah C Morse; Luciana C C Leite; Ana Paula Mattos Areas; Paulo Lee Ho; Flavia S Kubrusly; Igor Almeida; Porter Anderson
Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a nontoxic adjuvant.
Infection and immunity 2004;72(7):4290-2.
2003: Richard Malley; Philipp Henneke; Sarah C Morse; Michael J Cieslewicz; Marc Lipsitch; Claudette M Thompson; Evelyn A Kurt-Jones; James C Paton; Michael R Wessels; Douglas T Golenbock
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1966-71.
2003: Nathan Kuppermann; Richard Malley; W Charles Huskins
A new prognostic scoring system for meningococcal septic shock in children: comparison with three other scoring systems.
Intensive care medicine 2003;29(2):333; author reply 334.
2003: Deborah C Molrine; Joseph H Antin; Eva C Guinan; Robert J Soiffer; Kristin MacDonald; Richard Malley; Frank J Malinoski; Susan M Trocciola; Marjorie Wilson; Donna M Ambrosino
Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation.
Blood 2003;101(3):831-6.
2002: James P Marcin; Nicole Glaser; Peter Barnett; Ian McCaslin; David Nelson; Jennifer Trainor; Jeffrey Louie; Francine Kaufman; Kimberly S Quayle; Mark Roback; Richard Malley; Nathan Kuppermann
Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema.
The Journal of pediatrics 2002;141(6):793-7.
2002: Lise E Nigrovic; Nathan Kuppermann; Richard Malley
Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era.
Pediatrics 2002;110(4):712-9.
2002: Philipp Henneke; Osamu Takeuchi; Richard Malley; Egil Lien; Robin R Ingalls; Mason W Freeman; Tanya N Mayadas; Victor Nizet; Shizuo Akira; Dennis L Kasper; Douglas T Golenbock
Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3970-7.
2002: Tran Nguyen; Richard Malley; Stanley H Inkelis; Nathan Kuppermann
Comparison of prediction models for adverse outcome in pediatric meningococcal disease using artificial neural network and logistic regression analyses.
Journal of clinical epidemiology 2002;55(7):687-95.
2002: Stanley H Inkelis; Daniel O'Leary; Vincent J Wang; Richard Malley; Martha K Nicholson; Nathan Kuppermann
Extremity pain and refusal to walk in children with invasive meningococcal disease.
Pediatrics 2002;110(1 Pt 1):e3.
2002: Ofer Levy; Jean-Pierre Bourquin; Alisa McQueen; Alan B Cantor; Catherine Lachenauer; Richard Malley
Fatal disseminated Candida lusitaniae infection in an infant with chronic granulomatous disease.
The Pediatric infectious disease journal 2002;21(3):262-4.
2001: Vincent J Wang; Nathan Kuppermann; Richard Malley; E D Barnett; H Cody Meissner; E V Schmidt; Gary R Fleisher
Meningococcal disease among children who live in a large metropolitan area, 1981-1996.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001;32(7):1004-9.
2001: Nicole Glaser; P Barnett; Ian McCaslin; D Nelson; J Trainor; J Louie; F Kaufman; Kimberly S Quayle; M Roback; Richard Malley; Nathan Kuppermann
Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics.
The New England journal of medicine 2001;344(4):264-9.
2000: Vincent J Wang; Richard Malley; Gary R Fleisher; Stanley H Inkelis; Nathan Kuppermann
Antibiotic treatment of children with unsuspected meningococcal disease.
Archives of pediatrics & adolescent medicine 2000;154(6):556-60.
2000: John Belko; David L Wessel; Richard Malley
Endocarditis caused by Corynebacterium diphtheriae: case report and review of the literature.
The Pediatric infectious disease journal 2000;19(2):159-63.
2000: Anne M Stack; Richard Malley; RA Saladino; J B Montana; K L MacDonald; Deborah C Molrine
Primary respiratory syncytial virus infection: pathology, immune response, and evaluation of vaccine challenge strains in a new mouse model.
Vaccine 2000;18(14):1412-8.
2000: Richard Malley; Louis Vernacchio; John P DeVincenzo; Octavio Ramilo; Penelope H Dennehy; H Cody Meissner; William C Gruber; Hasan Jafri; P Sanchez; Kristin MacDonald; J B Montana; C M Thompson; Donna M Ambrosino
Enzyme-linked immunosorbent assay to assess respiratory syncytial virus concentration and correlate results with inflammatory mediators in tracheal secretions.
The Pediatric infectious disease journal 2000;19(1):1-7.
1999: Jon Bruss; Richard Malley; S Halperin; S Dobson; M Dhalla; J Mciver; George R Siber
Treatment of severe pertussis: a study of the safety and pharmacology of intravenous pertussis immunoglobulin.
The Pediatric infectious disease journal 1999;18(6):505-11.
1999: I L Feinerman; H K Tan; David W Roberson; Richard Malley; Margaret A Kenna
Necrotizing fasciitis of the pharynx following adenotonsillectomy.
International journal of pediatric otorhinolaryngology 1999;48(1):1-7.
1999: Nathan Kuppermann; Richard Malley; Stanley H Inkelis; Gary R Fleisher
Clinical and hematologic features do not reliably identify children with unsuspected meningococcal disease.
Pediatrics 1999;103(2):E20.
1998: Richard Malley; John P DeVincenzo; Octavio Ramilo; Penelope H Dennehy; H Cody Meissner; William C Gruber; P Sanchez; Hasan Jafri; �James F Balsley; David A Carlin; Steven C Buckingham; Louis Vernacchio; Donna M Ambrosino
Reduction of respiratory syncytial virus (RSV) in tracheal aspirates in intubated infants by use of humanized monoclonal antibody to RSV F protein.
The Journal of infectious diseases 1998;178(6):1555-61.
1998: Richard Malley; Stanley H Inkelis; P Coelho; W Charles Huskins; Nathan Kuppermann
Cerebrospinal fluid pleocytosis and prognosis in invasive meningococcal disease in children.
The Pediatric infectious disease journal 1998;17(10):855-9.
1998: Richard Malley; Anne M Stack; M L Ferretti; Claudette M Thompson; RA Saladino
Anticapsular polysaccharide antibodies and nasopharyngeal colonization with Streptococcus pneumoniae in infant rats.
The Journal of infectious diseases 1998;178(3):878-82.
1998: Anne M Stack; Richard Malley; Claudette M Thompson; L Kobzik; George R Siber; RA Saladino
Minimum protective serum concentrations of pneumococcal anti-capsular antibodies in infant rats.
The Journal of infectious diseases 1998;177(4):986-90.
1996: Richard Malley; W Charles Huskins; Nathan Kuppermann
Multivariable predictive models for adverse outcome of invasive meningococcal disease in children.
The Journal of pediatrics 1996;129(5):702-10.