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Roberto Mallone

Research Profile

Disorders

Type 1 Diabetes Mellitus

Anatomy

Chemicals & Drugs

Living Beings

Physiology

Lymphocyte Activation

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Publications

TOP 3
Sloboda Culina; Vedran Brezar; Roberto Mallone
Insulin and type 1 diabetes: immune connections.
Maria Candela Iglesias; Roberto Mallone; Céline Meaudre; Arnaud Moris; David A Price; Asier Saez-Cirion; Marie-Noëlle Ungeheuer; Olivia Briceno; Emma Gostick; Victor Appay
Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency.
S Culina; Roberto Mallone
Immune biomarkers in immunotherapeutic trials for type 1 diabetes: cui prodest?

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All Publications

2013: Sloboda Culina; Vedran Brezar; Roberto Mallone
Insulin and type 1 diabetes: immune connections.
European journal of endocrinology / European Federation of Endocrine Societies 2013;168(2):R19-31.
2013: Maria Candela Iglesias; Roberto Mallone; Céline Meaudre; Arnaud Moris; David A Price; Asier Saez-Cirion; Marie-Noëlle Ungeheuer; Olivia Briceno; Emma Gostick; Victor Appay
Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency.
Immunology letters 2013;149(1-2):119-22.
2012: S Culina; Roberto Mallone
Immune biomarkers in immunotherapeutic trials for type 1 diabetes: cui prodest?
Diabetes & metabolism 2012;38(5):379-85.
2012: Matthieu Scotto; Thomas Østerbye; Giulia Novelli; Cécile Raverdy; Georgia Afonso; Christian Boitard; Graziella Bruno; Søren Buus; Jean-Claude Carel; Céline Gonfroy-Leymarie; Etienne Larger; Odile Launay; François A Lemonnier; Sandrine Luce; Roberto Mallone
HLA-B7-restricted islet epitopes are differentially recognized in type 1 diabetic children and adults and form weak peptide-HLA complexes.
Diabetes 2012;61(10):2546-55.
2012: Adriaan H C de Jongste; Jan W Gratama; Jaco Kraan; Cor H J Lamers; Roberto Mallone; Emanuela Martinuzzi; Miranda de Graaf; Patricia D M van den Broek; Peter A E Sillevis Smitt
Three sensitive assays do not provide evidence for circulating HuD-specific T cells in the blood of patients with paraneoplastic neurological syndromes with anti-Hu antibodies.
Neuro-oncology 2012;14(7):841-8.
2012: M Scotto; L A Sechi; C Raverdy; G Afonso; B Baz; C Boitard; G Bruno; J C Carel; H W Davidson; D Dubois-Laforgue; J F Gautier; J C Hutton; E Larger; O Launay; F A Lemonnier; D Levy; Roberto Mallone
Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients.
Diabetologia 2012;55(7):2026-31.
2012: Vedran Brezar; Slobodan Culina; Marie-Claude Gagnerault; Roberto Mallone
Short-term subcutaneous insulin treatment delays but does not prevent diabetes in NOD mice.
European journal of immunology 2012;42(6):1553-61.
2012: Monica Boita; Sophie Caillat-Zucman; Alessandro Cignetti; Paola Circosta; Mathilde de Menthon; Angela Rita Elia; Enrico Heffler; Roberto Mallone; Emanuela Martinuzzi; Giovanni Rolla; Giuseppe Guida
Expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome.
Clinical and experimental rheumatology 2012;30(1 Suppl 70):S57-61.
2011: Sandrine Luce; Roberto Mallone; Sylviane Muller; Benedita Rocha; Jean-Paul Briand; Joel Coste; Najiba Lahlou; Etienne Larger; François Lemonnier; Christian Boitard
Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes.
Diabetes 2011;60(12):3289-99.
2011: Barbara Brooks-Worrell; Corrado M Cilio; I Durinovic-Bello; P Gottlieb; E James; O Lou; Roberto Mallone; Stuart I Mannering; B Menart; L Petrich de Marquesini; M Pham; J Reichow; R Rutter; Nanette C Schloot; R Schreiner; M Scotto; T Tree; S Wong; L Yang; Z Zhou
Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1 diabetic patients and controls.
Diabetes/metabolism research and reviews 2011;27(8):737-45.
2011: Eddie A James; N Jospe; O Lou; Roberto Mallone; M N Pham; J Reichow; Nanette C Schloot; J Thorpe; R Wagner; B M Brooks-Worrell; Ivana Durinovic-Belló; L Fitzgerald-Miller; Marie-Claude Gagnerault; P A Gottlieb
Immunology of Diabetes Society T-Cell Workshop: HLA class II tetramer-directed epitope validation initiative.
Diabetes/metabolism research and reviews 2011;27(8):727-36.
2011: Roberto Mallone; M Scotto; J Thorpe; R Wagner; F S Wong; Christian Boitard; C M Dayan; I Durinovic-Bellò; L Fitzgerald-Miller; P Gottlieb; Eddie A James; C N Janicki; N Jospe; O Lou
Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative.
Diabetes/metabolism research and reviews 2011;27(8):720-6.
2011: Slobodan Culina; Roberto Mallone
Pathogenic and regulatory T cells in type 1 diabetes: losing self-control, restoring it, and how to take the temperature.
Current diabetes reports 2011;11(5):426-33.
2011: Vedran Brezar; Jean-Claude Carel; Christian Boitard; Roberto Mallone
Beyond the hormone: insulin as an autoimmune target in type 1 diabetes.
Endocrine reviews 2011;32(5):623-69.
2011: Emanuela Martinuzzi; Diana Mittag; Gaetano Naselli; Laurence Zitvogel; Georgia Afonso; Christian Boitard; Nathalie Chaput; Béhazine Combadière; Marie-Claude Gagnerault; Leonard C Harrison; Roberto Mallone
acDCs enhance human antigen-specific T-cell responses.
Blood 2011;118(8):2128-37.
2011: Roberto Mallone; Vedran Brezar
To B or not to B: (anti)bodies of evidence on the crime scene of type 1 diabetes?
Diabetes 2011;60(8):2020-2.
2011: Julien Diana; Vedran Brezar; Lucie Beaudoin; Marc Dalod; Andrew L Mellor; Anna Tafuri; Matthias von Herrath; Christian Boitard; Roberto Mallone; Agnès Lehuen
Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay.
The Journal of experimental medicine 2011;208(4):729-45.
2011: Spiros Fourlanos; Christine Perry; Shane A Gellert; Emanuela Martinuzzi; Roberto Mallone; Jeanne Butler; Peter G Colman; Leonard C Harrison
Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes.
Diabetes 2011;60(4):1237-45.
2011: Speranza Masala; Daniela Paccagnini; Adolfo Pacifico; Niyaz Ahmed; Vedran Brezar; Davide Cossu; Roberto Mallone; Leonardo A Sechi
Antibodies recognizing Mycobacterium avium paratuberculosis epitopes cross-react with the beta-cell antigen ZnT8 in Sardinian type 1 diabetic patients.
PloS one 2011;6(10):e26931.
2011: Roberto Mallone; Vedran Brezar; Christian Boitard
T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives.
Clinical & developmental immunology 2011;2011():513210.
2011: Slobodan Culina; Christian Boitard; Roberto Mallone
Antigen-based immune therapeutics for type 1 diabetes: magic bullets or ordinary blanks?
Clinical & developmental immunology 2011;2011():286248.
2010: Diane Rottembourg; Cheri Deal; Marion Lambert; Roberto Mallone; Jean-Claude Carel; André Lacroix; Sophie Caillat-Zucman; Françoise Le Deist
21-Hydroxylase epitopes are targeted by CD8 T cells in autoimmune Addison's disease.
Journal of autoimmunity 2010;35(4):309-15.
2010: Georgia Afonso; Matthieu Scotto; Amédée Renand; Jeanette Arvastsson; Dominique Vassilieff; Corrado M Cilio; Roberto Mallone
Critical parameters in blood processing for T-cell assays: validation on ELISpot and tetramer platforms.
Journal of immunological methods 2010;359(1-2):28-36.
2008: Emanuela Martinuzzi; François A Lemonnier; Christian Boitard; Roberto Mallone
Measurement of CD8 T cell responses in human type 1 diabetes.
Annals of the New York Academy of Sciences 2008;1150():61-7.
2008: Emanuela Martinuzzi; Giulia Novelli; Matthieu Scotto; Philippe Blancou; Jean-Marie Bach; Lucy Chaillous; Graziella Bruno; Lucienne Chatenoud; Peter van Endert; Roberto Mallone
The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment.
Diabetes 2008;57(5):1312-20.
2008: Emanuela Martinuzzi; Matthieu Scotto; Emmanuelle Enée; Vedran Brezar; Jean-Antoine Ribeil; Peter van Endert; Roberto Mallone
Serum-free culture medium and IL-7 costimulation increase the sensitivity of ELISpot detection.
Journal of immunological methods 2008;333(1-2):61-70.
2008: Emmanuelle Enée; Emanuela Martinuzzi; Philippe Blancou; Jean-Marie Bach; Roberto Mallone; Peter van Endert
Equivalent specificity of peripheral blood and islet-infiltrating CD8+ T lymphocytes in spontaneously diabetic HLA-A2 transgenic NOD mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5430-8.
2008: Roberto Mallone; Peter van Endert
T cells in the pathogenesis of type 1 diabetes.
Current diabetes reports 2008;8(2):101-6.
2007: Philippe Blancou; Roberto Mallone; Emanuela Martinuzzi; Sabine Sévère; Sylvie Pogu; Giulia Novelli; Graziella Bruno; Bernard Charbonnel; Manuel Dolz; Lucy Chaillous; Peter van Endert; Jean-Marie Bach
Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):7458-66.
2007: Roberto Mallone; Emanuela Martinuzzi; Philippe Blancou; Giulia Novelli; Georgia Afonso; Manuel Dolz; Graziella Bruno; Lucy Chaillous; Lucienne Chatenoud; Jean-Marie Bach; Peter van Endert
CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes.
Diabetes 2007;56(3):613-21.
2006: Peter van Endert; Yousra Hassainya; Vivian Lindo; Jean-Marie Bach; Philippe Blancou; François Lemonnier; Roberto Mallone
HLA class I epitope discovery in type 1 diabetes.
Annals of the New York Academy of Sciences 2006;1079():190-7.
2006: Roberto Mallone; Paolo Cavallo Perin
Anti-CD38 autoantibodies in type? diabetes.
Diabetes/metabolism research and reviews 2006;22(4):284-94.
2005: Roberto Mallone; Gerald Nepom
Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetes.
American journal of therapeutics 2005;12(6):534-50.
2005: Roberto Mallone; Sharon A Kochik; Helena Reijonen; Bryan Carson; Steven F Ziegler; William W Kwok; Gerald Nepom
Functional avidity directs T-cell fate in autoreactive CD4+ T cells.
Blood 2005;106(8):2798-805.
2004: Helena Reijonen; Roberto Mallone; Anne-Kristin Heninger; Elsa M Laughlin; Sharon A Kochik; Ben A Falk; William W Kwok; Carla J Greenbaum; Gerald Nepom
GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.
Diabetes 2004;53(8):1987-94.
2004: Roberto Mallone; Sharon A Kochik; Elsa M Laughlin; Vivian H Gersuk; Helena Reijonen; William W Kwok; Gerald Nepom
Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.
Diabetes 2004;53(4):971-7.
2004: Roberto Mallone; Gerald Nepom
MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete.
Clinical immunology (Orlando, Fla.) 2004;110(3):232-42.
2003: Attilio Allione; Fulvio Pomero; Susanna Valpreda; Massimo Porta; Roberto Mallone; Claudio Rabbia; Paolo Cavallo-Perin
Worsening of hypertension in a pregnant woman with renal arteriovenous malformation: a successful superselective embolization after delivery.
Clinical nephrology 2003;60(3):211-3.
2002: Roberto Mallone; Erika Ortolan; Silvia Pinach; M Volante; Maria M Zanone; Graziella Bruno; Germano Baj; Tobias Lohmann; Paolo Cavallo-Perin; Fabio Malavasi
Anti-CD38 autoantibodies: characterisation in new-onset type I diabetes and latent autoimmune diabetes of the adult (LADA) and comparison with other islet autoantibodies.
Diabetologia 2002;45(12):1667-77.
2002: Carlo Chizzolini; Elena Raschi; Roger Rezzonico; Cinzia Testoni; Roberto Mallone; Armando Gabrielli; Andrea Facchini; Nicoletta Del Papa; Maria Orietta Borghi; Jean-Michel Dayer; Pier Luigi Meroni
Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis.
Arthritis and rheumatism 2002;46(6):1602-13.
2002: Germano Baj; Alberto Arnulfo; Silvia Deaglio; Roberto Mallone; Alessandro Vigone; Maria Grazia De Cesaris; Nicola Surico; Fabio Malavasi; Enza Ferrero
Arsenic trioxide and breast cancer: analysis of the apoptotic, differentiative and immunomodulatory effects.
Breast cancer research and treatment 2002;73(1):61-73.
2001: Roberto Mallone; Erika Ortolan; Germano Baj; Ada Funaro; Sara Giunti; Emma Lillaz; Franca Saccucci; Maurizio Cassader; Paolo Cavallo-Perin; Fabio Malavasi
Autoantibody response to CD38 in Caucasian patients with type 1 and type 2 diabetes: immunological and genetic characterization.
Diabetes 2001;50(4):752-62.
2001: Roberto Mallone; Ada Funaro; Mercedes Zubiaur; Germano Baj; Clara Maria Ausiello; Carlo Tacchetti; Jaime Sancho; Carlo E Grossi; Fabio Malavasi
Signaling through CD38 induces NK cell activation.
International immunology 2001;13(4):397-409.
2001: Silvia Deaglio; Roberto Mallone; Germano Baj; D Donati; Giuseppe Giraudo; F Corno; S Bruzzone; Massimo Geuna; Clara Maria Ausiello; Fabio Malavasi
Human CD38 and its ligand CD31 define a unique lamina propria T lymphocyte signaling pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):580-2.
2000: Marie-Thérèse Zilber; S Gregory; Roberto Mallone; Silvia Deaglio; Fabio Malavasi; Dominique Charron; Catherine Gelin
CD38 expressed on human monocytes: a coaccessory molecule in the superantigen-induced proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2840-5.
2000: Germano Baj; Alberto Arnulfo; Silvia Deaglio; Roberto Mallone; Alessandro Vigone; M Rosa; M Giana; L Villa; Fabio Malavasi; Nicola Surico
Retinoids in breast cancer prevention and treatment. A review of the literature.
European journal of gynaecological oncology 2000;21(4):411-5.
2000: Silvia Deaglio; Roberto Mallone; Germano Baj; Alberto Arnulfo; Nicola Surico; Umberto Dianzani; K Mehta; Fabio Malavasi
CD38/CD31, a receptor/ligand system ruling adhesion and signaling in human leukocytes.
Chemical immunology 2000;75():99-120.
1998: Yair Levy; Boris Gilburd; Jacob George; Nicoletta Del Papa; Roberto Mallone; maya damianovich; Miri Blank; Antonella Radice; Yves Renaudineau; Pierre Youinou; A Wiik; Fabio Malavasi; Pier Luigi Meroni; Yehuda Shoenfeld
Characterization of murine monoclonal anti-endothelial cell antibodies (AECA) produced by idiotypic manipulation with human AECA.
International immunology 1998;10(7):861-8.
1998: Roberto Mallone; S Ferrua; Massimo Morra; E Zocchi; K Mehta; L D Notarangelo; Fabio Malavasi
Characterization of a CD38-like 78-kilodalton soluble protein released from B cell lines derived from patients with X-linked agammaglobulinemia.
The Journal of clinical investigation 1998;101(12):2821-30.
1998: Silvia Deaglio; Massimo Morra; Roberto Mallone; Clara Maria Ausiello; Elisabeth Prager; Giovanni Garbarino; Umberto Dianzani; Hannes Stockinger; Fabio Malavasi
Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):395-402.