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Paul Malthouse

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Nuclear Magnetic Resonance, Biomolecular

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Teodolinda Petrillo; Catrina A O'Donohoe; Nicole Howe; J Paul G Malthouse
Importance of tetrahedral intermediate formation in the catalytic mechanism of the serine proteases chymotrypsin and subtilisin.
Nicole Howe; Mariangela Ceruso; Edward Spink; J Paul G Malthouse
pH stability of the stromelysin-1 catalytic domain and its mechanism of interaction with a glyoxal inhibitor.
Kalyana C Venneti; J Paul G Malthouse; Finbarr P M O'Harte; Chandralal Hewage
Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide.

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All Publications

2012: Teodolinda Petrillo; Catrina A O'Donohoe; Nicole Howe; J Paul G Malthouse
Importance of tetrahedral intermediate formation in the catalytic mechanism of the serine proteases chymotrypsin and subtilisin.
Biochemistry 2012;51(31):6164-70.
2011: Nicole Howe; Mariangela Ceruso; Edward Spink; J Paul G Malthouse
pH stability of the stromelysin-1 catalytic domain and its mechanism of interaction with a glyoxal inhibitor.
Biochimica et biophysica acta 2011;1814(10):1394-403.
2011: Kalyana C Venneti; J Paul G Malthouse; Finbarr P M O'Harte; Chandralal Hewage
Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide.
Biochimica et biophysica acta 2011;1814(7):882-8.
2009: Nicole Howe; Louis Rogers; Chandralal Hewage; J Paul G Malthouse
Oxyanion and tetrahedral intermediate stabilisation by subtilisin: detection of a new tetrahedral adduct.
Biochimica et biophysica acta 2009;1794(8):1251-8.
2009: Neville H McClenaghan; Siobhan M Scullion; Brian Mion; Chandralal Hewage; J Paul G Malthouse; Peter R Flatt; Philip Newsholme; Lorraine Brennan
Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells.
Clinical science (London, England : 1979) 2009;116(4):341-51.
2007: Edward Spink; Chandralal Hewage; J Paul G Malthouse
Determination of the structure of tetrahedral transition state analogues bound at the active site of chymotrypsin using 18O and 2H isotope shifts in the 13C NMR spectra of glyoxal inhibitors.
Biochemistry 2007;46(44):12868-74.
2007: Sonya Cosgrove; Louis Rogers; Chandralal Hewage; J Paul G Malthouse
NMR study of the inhibition of pepsin by glyoxal inhibitors: mechanism of tetrahedral intermediate stabilization by the aspartyl proteases.
Biochemistry 2007;46(39):11205-15.
2007: Iñigo Alaña; J Paul G Malthouse; Finbarr P M O'Harte; Chandralal Hewage
The bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy.
Proteins 2007;68(1):92-9.
2007: J Paul G Malthouse
13C- and 1H-NMR studies of oxyanion and tetrahedral intermediate stabilization by the serine proteinases: optimizing inhibitor warhead specificity and potency by studying the inhibition of the serine proteinases by peptide-derived chloromethane and glyoxal inhibitors.
Biochemical Society transactions 2007;35(Pt 3):566-70.
2007: Edward Spink; Sonya Cosgrove; Louis Rogers; Chandralal Hewage; J Paul G Malthouse
13C and 1H NMR studies of ionizations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes.
The Journal of biological chemistry 2007;282(11):7852-61.
2006: Lorraine Brennan; Chandralal Hewage; J Paul G Malthouse; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism.
The FEBS journal 2006;273(22):5160-8.
2006: Marianne C Walsh; Lorraine Brennan; J Paul G Malthouse; Helen M Roche; Mike joseph Gibney
Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans.
The American journal of clinical nutrition 2006;84(3):531-9.
2006: Iñigo Alaña; Jeremy C Parker; Victor A Gault; Peter R Flatt; Finbarr P M O'Harte; J Paul G Malthouse; Chandralal Hewage
NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water.
The Journal of biological chemistry 2006;281(24):16370-6.
2006: Lorraine Brennan; Paula M Alves; Chandralal Hewage; J Paul G Malthouse; Gethin J McBean
Impact of the gliotoxin L-serine-O-sulphate on cellular metabolism in cultured rat astrocytes.
Neurochemistry international 2006;48(8):739-45.
2005: Aleksandra Djurdjevic-Pahl; Chandralal Hewage; J Paul G Malthouse
Ionisations within a subtilisin-glyoxal inhibitor complex.
Biochimica et biophysica acta 2005;1749(1):33-41.
2004: Iñigo Alaña; Chandralal Hewage; J Paul G Malthouse; Jeremy C Parker; Victor A Gault; Finbarr P M O'Harte
NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide.
Biochemical and biophysical research communications 2004;325(1):281-6.
2004: Lorraine Brennan; Chandralal Hewage; J Paul G Malthouse; Gethin J McBean
Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study.
Neurochemistry international 2004;45(8):1155-65.
2004: Krisztina Toth; Tina L Amyes; John Patrick Richard; J Paul G Malthouse; Máire E NíBeilliú
Claisen-type addition of glycine to pyridoxal in water.
Journal of the American Chemical Society 2004;126(34):10538-9.
2004: Máire E Níbeilliú; J Paul G Malthouse
The stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the alpha-protons of amino acids.
The Biochemical journal 2004;381(Pt 3):847-52.
2004: S J Brooks; E M Doyle; Chandralal Hewage; J Paul G Malthouse; Wouter A Duetz; K E O' Connor
Biotransformation of halophenols using crude cell extracts of Pseudomonas putida F6.
Applied microbiology and biotechnology 2004;64(4):486-92.
2003: L Brennan; Mary Corless; Chandralal Hewage; J Paul G Malthouse; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line.
Diabetologia 2003;46(11):1512-21.
2003: Lorraine Brennan; Chandralal Hewage; J Paul G Malthouse; Gethin J McBean
An NMR study of alterations in [1-13C]glucose metabolism in C6 glioma cells by gliotoxic amino acids.
Neurochemistry international 2003;42(6):441-8.
2003: J Paul G Malthouse
Stereospecificity of alpha-proton exchange reactions catalysed by pyridoxal-5'-phosphate-dependent enzymes.
Biochimica et biophysica acta 2003;1647(1-2):138-42.
2002: Jonathan Lowther; Aleksandra Djurdjevic-Pahl; Chandralal Hewage; J Paul G Malthouse
A 13C-NMR study of the inhibition of papain by a dipeptide-glyoxal inhibitor.
The Biochemical journal 2002;366(Pt 3):983-7.
2002: Lorraine Brennan; Aine Shine; Chandralal Hewage; J Paul G Malthouse; Kevin M Brindle; Neville H McClenaghan; Peter R Flatt; Philip Newsholme
A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.
Diabetes 2002;51(6):1714-21.
2002: Aleksandra Djurdjevic-Pahl; Chandralal Hewage; J Paul G Malthouse
13C-NMR study of the inhibition of delta-chymotrypsin by a tripeptide-glyoxal inhibitor.
The Biochemical journal 2002;362(Pt 2):339-47.
1999: MM Mahon; R Graber; Philipp Christen; J Paul G Malthouse
The aspartate aminotransferase-catalysed exchange of the alpha-protons of aspartate and glutamate: the effects of the R386A and R292V mutations on this exchange reaction.
Biochimica et biophysica acta 1999;1434(1):191-201.
1999: J Paul G Malthouse
Using NMR as a probe of protein structure and function.
Biochemical Society transactions 1999;27(4):701-13.
1999: D B O'Sullivan; Timothy O'Connell; MM Mahon; A Koenig; J J Milne; TB Fitzpatrick; J Paul G Malthouse
13C NMR study of how the oxyanion pKa values of subtilisin and chymotrypsin tetrahedral adducts are affected by different amino acid residues binding in enzyme subsites S1-S4.
Biochemistry 1999;38(19):6187-94.
1999: Gary Yalloway; Stephen G Mayhew; J Paul G Malthouse; M E Gallagher; G P Curley
pH-dependent spectroscopic changes associated with the hydroquinone of FMN in flavodoxins.
Biochemistry 1999;38(12):3753-62.
1998: TB Fitzpatrick; J Paul G Malthouse
The effect of histidine-228 on the catalytic efficiency and stereospecificity of the serine hydroxymethyltransferase catalysed exchange of the alpha-protons of amino acids.
Biochimica et biophysica acta 1998;1386(1):220-6.
1998: MM Mahon; Svetlana Gramatikova; Philipp Christen; TB Fitzpatrick; J Paul G Malthouse
The pyridoxal-5'-phosphate-dependent catalytic antibody 15A9: its efficiency and stereospecificity in catalysing the exchange of the alpha-protons of glycine.
FEBS letters 1998;427(1):74-8.
1998: TB Fitzpatrick; J Paul G Malthouse
A substrate-induced change in the stereospecificity of the serine-hydroxymethyltransferase-catalysed exchange of the alpha-protons of amino acids--evidence for a second catalytic site.
European journal of biochemistry / FEBS 1998;252(1):113-7.
1998: Timothy O'Connell; J Paul G Malthouse
Effect of the bulk solvent on the pKa values of the oxyanions of serine protease derivatives.
Biochemical Society transactions 1998;26(1):S70.
1998: P Phelan; J Paul G Malthouse
Quenching of beta-lactoglobulin fluorescence by 2-nitro-5-thiobenzoic acid.
Biochemical Society transactions 1998;26(1):S69.
1998: Declan A Healy; MM Mahon; J Paul G Malthouse
An attempt to cyanylate the thiol group of bovine serum albumin with 13C-enriched cyanide and to observe the thiocyanate carbon by 13C-NMR.
Biochemical Society transactions 1998;26(1):S68.
1998: D B O'Sullivan; E Murphy; Timothy O'Connell; E A Murphy; J Paul G Malthouse
Synthesis of benzyloxycarbonylglycylglycinephenylalanine p-nitroanilide and an evaluation of its potential as a substrate for alpha-chymotrypsin and subtilisin BPN'.
Biochemical Society transactions 1998;26(1):S67.
1998: J Paul G Malthouse; TB Fitzpatrick; MM Mahon
A comparison of some of the methods available for analysing the substrate dependence of the exchange of the alpha-protons of amino acids catalysed by pyridoxal-phosphate-dependent enzymes.
Biochemical Society transactions 1998;26(1):S66.
1997: J Paul G Malthouse; TB Fitzpatrick; J J Milne; Leif Grehn; Ulf Ragnarsson
Enzymatic synthesis of isotopically labelled serine and tryptophan for application in peptide synthesis.
Journal of peptide science : an official publication of the European Peptide Society 1997;3(5):361-6.
1996: Timothy O'Connell; J Paul G Malthouse
Determination of the ionization state of the active-site histidine in a subtilisin-(chloromethane inhibitor) derivative by 13C-NMR.
The Biochemical journal 1996;317 ( Pt 1)():35-40.
1996: J J Milne; J Paul G Malthouse
The effect of different amino acid side chains on the stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the alpha-protons of amino acids.
The Biochemical journal 1996;314 ( Pt 3)():787-91.
1996: M E Gallagher; Stephen G Mayhew; J Paul G Malthouse; M F Fillat
Cyanylation of the thiol of the cysteine of flavodoxin from Anabaena PCC 7119.
Biochemical Society transactions 1996;24(1):40S.
1996: Timothy O'Connell; J Paul G Malthouse
A 1H-NMR study of the histidine resonance's of native subtilisin and of subtilisin inhibited by benzyloxycarbonylglycylglycylphenylalanyl-chloromethane.
Biochemical Society transactions 1996;24(1):135S.
1996: J Paul G Malthouse; J J Milne; TB Fitzpatrick; MM Mahon
Kinetic analysis of the exchange of the alpha-protons of amino acids by pyridoxal-phosphate-dependent enzymes.
Biochemical Society transactions 1996;24(1):134S.
1996: J J Milne; J Paul G Malthouse
Enzymatic synthesis of alpha-deuterated amino acids.
Biochemical Society transactions 1996;24(1):133S.
1996: TB Fitzpatrick; J Paul G Malthouse
Proof that serine hydroxymethyltransferase retains its specificity for the pro-2S proton of glycine in the absence of tetrahydrofolate.
Biochemical Society transactions 1996;24(1):132S.
1996: MM Mahon; J Paul G Malthouse
A study of the pH dependence of the reaction of benzyloxycarbonyltryptophanylchloromethane with chymotrypsin.
Biochemical Society transactions 1996;24(1):131S.
1996: P Phelan; J Paul G Malthouse
1H-NMb spectroscopy of beta-thiocyanatoalanine.
Biochemical Society transactions 1996;24(1):130S.
1996: E A Murphy; Timothy O'Connell; J Paul G Malthouse
The synthesis and characterisation of a glyoxal inhibitor of chymotrypsin.
Biochemical Society transactions 1996;24(1):129S.
1995: J J Milne; J Paul G Malthouse
Factors affecting the stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the pro-2R and pro-2S protons of glycine.
The Biochemical journal 1995;311 ( Pt 3)():1015-9.
1995: Timothy O'Connell; J Paul G Malthouse
A study of the stabilization of the oxyanion of tetrahedral adducts by trypsin, chymotrypsin and subtilisin.
The Biochemical journal 1995;307 ( Pt 2)():353-9.
1995: J Paul G Malthouse; P Phelan
Effect of magnetic field strength on the linewidth and spin-lattice relaxation time of the thiocyanate carbon of cyanylated beta-lactoglobulin B: optimization of the experimental parameters for observing thiocyanate carbons in proteins.
The Biochemical journal 1995;306 ( Pt 2)():531-5.
1994: P Phelan; J Paul G Malthouse
13C-n.m.r. of the cyanylated beta-lactoglobulins: evidence that Cys-121 provides the thiol group of beta-lactoglobulins A and B.
The Biochemical journal 1994;302 ( Pt 2)():511-6.
1994: J J Milne; J Paul G Malthouse
A study of the tryptophan synthase catalysed H/D exchange of the alpha-protons of amino acids.
Biochemical Society transactions 1994;22(1):43S.
1994: P Phelan; J Paul G Malthouse
A 13C-n.m.r. study of cyanylated beta-lactoglobulins.
Biochemical Society transactions 1994;22(1):31S.
1994: Timothy O'Connell; M D Finucane; J Paul G Malthouse
The use of 13C n.m.r. and saturation transfer to detect tetrahedral intermediates in reactions catalysed by chymotrypsin and also in an amide inhibitor complex.
Biochemical Society transactions 1994;22(1):30S.
1993: Gerard M Doherty; Stephen G Mayhew; J Paul G Malthouse
13C-n.m.r. of the cyanylated apoflavodoxin and flavodoxin from Clostridium pasteurianum.
The Biochemical journal 1993;294 ( Pt 1)():215-8.
1992: M D Finucane; J Paul G Malthouse
A study of the stabilization of tetrahedral adducts by trypsin and delta-chymotrypsin.
The Biochemical journal 1992;286 ( Pt 3)():889-900.
1992: Gerard M Doherty; R Motherway; Stephen G Mayhew; J Paul G Malthouse
13C NMR of cyanylated flavodoxin from Megasphaera elsdenii and of thiocyanate model compounds.
Biochemistry 1992;31(34):7922-30.
1991: J Paul G Malthouse; M D Finucane
A study of the relaxation parameters of a 13C-enriched methylene carbon and a 13C-enriched perdeuteromethylene carbon attached to chymotrypsin.
The Biochemical journal 1991;280 ( Pt 3)():649-57.
1991: J Paul G Malthouse; J J Milne; L S Gariani
A comparative study of the kinetics and stereochemistry of the serine hydroxymethyltransferase- and tryptophan synthase-catalysed exchange of the pro-2R and pro-2S protons of glycine.
The Biochemical journal 1991;274 ( Pt 3)():807-12.
1989: M D Finucane; E A Hudson; J Paul G Malthouse
A 13C-n.m.r. investigation of the ionizations within an inhibitor--alpha-chymotrypsin complex. Evidence that both alpha-chymotrypsin and trypsin stabilize a hemiketal oxyanion by similar mechanisms.
The Biochemical journal 1989;258(3):853-9.