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David Mancuso
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Research Profile (preview)
Chemicals & Drugs
Living Beings
Procedures
Anatomy
Genes & Molecular Sequences
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Physiology
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Network (preview)
20
Gross, Richard
13
Jenkins, Christopher
11
Han, Xianlin
6
Sims, Harold
5
Yang, Jingyue
4
Yang, Kui
4
Yan, Wei
3
Abendschein, Dana
2
Su, Xiong
2
Turk, John
2
Bickel, Perry
2
Saffitz, Jeffrey
2
cheng, hua
1
Sambandam, Nandakumar
1
Schmidt, Robert
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Publications
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Geonetwork of David Mancuso (preview)
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All Publications
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2008: Cheng Hua; Mancuso David J; Jiang Xuntian; Guan Shaoping; Yang Jingyue; Yang Kui; Sun Gang; Gross Richard W; Han Xianlin
Shotgun lipidomics reveals the temporally dependent, highly diversified cardiolipin profile in the mammalian brain: temporally coordinated postnatal diversification of cardiolipin molecular species with neuronal remodeling.
Biochemistry 2008;47(21):5869-80.
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2008: Malik Ibrahim; Turk John; Mancuso David J; Montier Laura; Wohltmann Mary; Wozniak David F; Schmidt Robert E; Gross Richard W; Kotzbauer Paul T
Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations.
The American journal of pathology 2008;172(2):406-16.
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2007: Mancuso David J; Sims Harold F; Han Xianlin; Jenkins Christopher M; Guan Shao Ping; Yang Kui; Moon Sung Ho; Pietka Terri; Abumrad Nada A; Schlesinger Paul H; Gross Richard W
Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype.
The Journal of biological chemistry 2007;282(48):34611-22.
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2007: Mancuso David J; Han Xianlin; Jenkins Christopher M; Lehman John J; Sambandam Nandakumar; Sims Harold F; Yang Jingyue; Yan Wei; Yang Kui; Green Karen; Abendschein Dana R; Saffitz Jeffrey E; Gross Richard W
Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma.
The Journal of biological chemistry 2007;282(12):9216-27.
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2006: Jenkins Christopher M; Yan Wei; Mancuso David J; Gross Richard W
Highly selective hydrolysis of fatty acyl-CoAs by calcium-independent phospholipase A2beta. Enzyme autoacylation and acyl-CoA-mediated reversal of calmodulin inhibition of phospholipase A2 activity.
The Journal of biological chemistry 2006;281(23):15615-24.
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2005: Gross Richard W; Jenkins Christopher M; Yang Jingyue; Mancuso David J; Han Xianlin
Functional lipidomics: the roles of specialized lipids and lipid-protein interactions in modulating neuronal function.
Prostaglandins & other lipid mediators 2005;77(1-4):52-64.
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2005: Yan Wei; Jenkins Christopher M; Han Xianlin; Mancuso David J; Sims Harold F; Yang Kui; Gross Richard W
The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling.
The Journal of biological chemistry 2005;280(29):26669-79.
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2005: Gubitosi-Klug Rose A; Mancuso David J; Gross Richard W
The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequence.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):5964-8.
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2005: Su Xiong; Han Xianlin; Mancuso David J; Abendschein Dana R; Gross Richard W
Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium: identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics.
Biochemistry 2005;44(13):5234-45.
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2005: Wang Zhepeng; Ramanadham Sasanka; Ma Zhongmin Alex; Bao Shunzhong; Mancuso David J; Gross Richard W; Turk John
Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells.
The Journal of biological chemistry 2005;280(8):6840-9.
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2004: Mancuso David J; Jenkins Christopher M; Sims Harold F; Cohen Joshua M; Yang Jingyue; Gross Richard W
Complex transcriptional and translational regulation of iPLAgamma resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization.
European journal of biochemistry / FEBS 2004;271(23-24):4709-24.
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2004: Han Xianlin; Cheng Hua; Mancuso David J; Gross Richard W
Caloric restriction results in phospholipid depletion, membrane remodeling, and triacylglycerol accumulation in murine myocardium.
Biochemistry 2004;43(49):15584-94.
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2004: Jenkins Christopher M; Mancuso David J; Yan Wei; Sims Harold F; Gibson Beverly; Gross Richard W
Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.
The Journal of biological chemistry 2004;279(47):48968-75.
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2004: Su Xiong; Han Xianlin; Yang Jingyue; Mancuso David J; Chen Jeannie; Bickel Perry E; Gross Richard W
Sequential ordered fatty acid alpha oxidation and Delta9 desaturation are major determinants of lipid storage and utilization in differentiating adipocytes.
Biochemistry 2004;43(17):5033-44.
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2004: Su Xiong; Mancuso David J; Bickel Perry E; Jenkins Christopher M; Gross Richard W
Small interfering RNA knockdown of calcium-independent phospholipases A2 beta or gamma inhibits the hormone-induced differentiation of 3T3-L1 preadipocytes.
The Journal of biological chemistry 2004;279(21):21740-8.
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2003: Jenkins Christopher M; Han Xianlin; Yang Jingyue; Mancuso David J; Sims Harold F; Muslin Anthony J; Gross Richard W
Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis.
Biochemistry 2003;42(40):11798-807.
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2003: Mancuso David J; Abendschein Dana R; Jenkins Christopher M; Han Xianlin; Saffitz Jeffrey E; Schuessler Richard B; Gross Richard W
Cardiac ischemia activates calcium-independent phospholipase A2beta, precipitating ventricular tachyarrhythmias in transgenic mice: rescue of the lethal electrophysiologic phenotype by mechanism-based inhibition.
The Journal of biological chemistry 2003;278(25):22231-6.
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2002: Jenkins Christopher M; Han Xianlin; Mancuso David J; Gross Richard W
Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s.
The Journal of biological chemistry 2002;277(36):32807-14.
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2001: Jenkins C M; Wolf M J; Mancuso D J; Gross R W
Identification of the calmodulin-binding domain of recombinant calcium-independent phospholipase A2beta. implications for structure and function.
The Journal of biological chemistry 2001;276(10):7129-35.
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2000: Mancuso D J; Jenkins C M; Gross R W
The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2).
The Journal of biological chemistry 2000;275(14):9937-45.
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