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Md Nawajes Mandal

Research Profile

Chemicals & Drugs

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Retina

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Publications

TOP 3
Man Yu; Robert E Anderson; Aaron Benham; Richard S Brush; Sreemathi Logan; Md Nawajes A Mandal; Martin-Paul Agbaga
ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3.
Yimin Zhong; Robert E Anderson; Chen Chen; Yun-Zheng Le; Jingming Li; Md Nawajes A Mandal; Anisse Saadi; Julie-Thu A Tran; Joshua J Wang; Qiang Yu; Sarah X Zhang
X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium.
Hui Chen; Robert E Anderson; Julie-Thu A Tran; Md Nawajes A Mandal
Caffeic acid phenethyl ester protects 661W cells from H2O2-mediated cell death and enhances electroretinography response in dim-reared albino rats.

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All Publications

2012: Man Yu; Robert E Anderson; Aaron Benham; Richard S Brush; Sreemathi Logan; Md Nawajes A Mandal; Martin-Paul Agbaga
ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3.
Journal of lipid research 2012;53(3):494-504.
2012: Yimin Zhong; Robert E Anderson; Chen Chen; Yun-Zheng Le; Jingming Li; Md Nawajes A Mandal; Anisse Saadi; Julie-Thu A Tran; Joshua J Wang; Qiang Yu; Sarah X Zhang
X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium.
PloS one 2012;7(6):e38616.
2012: Hui Chen; Robert E Anderson; Julie-Thu A Tran; Md Nawajes A Mandal
Caffeic acid phenethyl ester protects 661W cells from H2O2-mediated cell death and enhances electroretinography response in dim-reared albino rats.
Molecular vision 2012;18():1325-38.
2011: Md Nawajes A Mandal; Gennadiy P Moiseyev; Olga Nikolaeva; Lixin Zheng; Hui Chen; Michael H Elliott; Robert A Floyd; Anne Kasus-Jacobi; Xiaoman Li; Jian-Xing Ma; Robert E Anderson
Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity.
The Journal of biological chemistry 2011;286(37):32491-501.
2010: Richard S Brush; Julie-Thu A Tran; Kimberly R Henry; Mark E McClellan; Michael H Elliott; Md Nawajes A Mandal
Retinal sphingolipids and their very-long-chain fatty acid-containing species.
Investigative ophthalmology & visual science 2010;51(9):4422-31.
2010: Martin-Paul Agbaga; Md Nawajes A Mandal; Robert E Anderson
Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein.
Journal of lipid research 2010;51(7):1624-42.
2010: Martin-Paul Agbaga; Richard S Brush; Md Nawajes A Mandal; Michael H Elliott; Muayyad R Al-Ubaidi; Robert E Anderson
Role of Elovl4 protein in the biosynthesis of docosahexaenoic acid.
Advances in experimental medicine and biology 2010;664():233-42.
2010: Lea D Marchette; Debra A Thompson; Marina Kravtsova; Thierry N Ngansop; Md Nawajes A Mandal; Anne Kasus-Jacobi
Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells.
Free radical biology & medicine 2010;48(1):16-25.
2009: G Bhanuprakash Reddy; Vidyullatha Vasireddy; Md Nawajes A Mandal; Mrudula Tiruvalluru; Xiaofei F Wang; Monica M Jablonski; Giridharan Nappanveettil; Radha Ayyagari
A novel rat model with obesity-associated retinal degeneration.
Investigative ophthalmology & visual science 2009;50(7):3456-63.
2009: Md Nawajes A Mandal; Jagan M R Patlolla; Lixin Zheng; Martin-Paul Agbaga; Julie-Thu A Tran; Lea Wicker; Anne Kasus-Jacobi; Michael H Elliott; Chinthalapally V Rao; Robert E Anderson
Curcumin protects retinal cells from light-and oxidant stress-induced cell death.
Free radical biology & medicine 2009;46(5):672-9.
2008: Bo Chang; Md Nawajes A Mandal; Venkata R M Chavali; Norman L Hawes; Naheed W Khan; Ronald E Hurd; Richard S Smith; Muriel L Davisson; Laura Kopplin; Barbara E K Klein; Ronald Klein; Sudha K Iyengar; John R Heckenlively; Radha Ayyagari
Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 gene.
Human molecular genetics 2008;17(24):3929-41.
2008: Martin-Paul Agbaga; Richard S Brush; Md Nawajes A Mandal; Kimberly Henry; Michael H Elliott; Robert E Anderson
Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12843-8.
2007: Vidyullatha Vasireddy; Yoshikazu Uchida; Norman Salem; Soo Yeon Kim; Md Nawajes A Mandal; G Bhanuprakash Reddy; Ravi Bodepudi; Nathan L Alderson; Johnie C Brown; Hiroko Hama; Andrzej Dlugosz; Peter M Elias; Walter M Holleran; Radha Ayyagari
Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.
Human molecular genetics 2007;16(5):471-82.
2006: Md Nawajes A Mandal; Vidyullatha Vasireddy; Monica M Jablonski; Xiaofei Wang; John R Heckenlively; Bret A Hughes; G Bhanuprakash Reddy; Radha Ayyagari
Spatial and temporal expression of MFRP and its interaction with CTRP5.
Investigative ophthalmology & visual science 2006;47(12):5514-21.
2006: Md Nawajes A Mandal; Vidyullatha Vasireddy; G Bhanuprakash Reddy; Xiaofei Wang; Sayoko E Moroi; Bikash R Pattnaik; Bret A Hughes; John R Heckenlively; Peter F Hitchcock; Monica M Jablonski; Radha Ayyagari
CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion.
Investigative ophthalmology & visual science 2006;47(12):5505-13.
2006: Vidyullatha Vasireddy; Monica M Jablonski; Md Nawajes A Mandal; Dorit Raz-Prag; Xiaofei F Wang; Lesli Nizol; Alessandro Iannaccone; David C Musch; Ronald A Bush; Norman Salem; Paul Sieving; Radha Ayyagari
Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration.
Investigative ophthalmology & visual science 2006;47(10):4558-68.
2006: Md Nawajes A Mandal; Radha Ayyagari
Complement factor H: spatial and temporal expression and localization in the eye.
Investigative ophthalmology & visual science 2006;47(9):4091-7.
2006: Dorit Raz-Prag; Radha Ayyagari; Robert Fariss; Md Nawajes A Mandal; Vidyullatha Vasireddy; Sharon Majchrzak-Hong; Andrea L Webber; Ronald A Bush; Norman Salem; Konstantin Petrukhin; Paul Sieving
Haploinsufficiency is not the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease.
Investigative ophthalmology & visual science 2006;47(8):3603-11.
2005: Charles M Krafchak; Hemant Pawar; Sayoko E Moroi; Alan Sugar; Paul R Lichter; David A Mackey; Shahzad I Mian; Theresa M Cooney; Victor M Elner; Miriam T Schteingart; Catherine A Downs; Theresa Guckian Kijek; Jenae M Johnson; Edward H Trager; Frank W Rozsa; Md Nawajes A Mandal; Michael P Epstein; Douglas Vollrath; Radha Ayyagari; Michael Boehnke; Julia E Richards
Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells.
American journal of human genetics 2005;77(5):694-708.
2005: Radha Ayyagari; Md Nawajes A Mandal; Athanasios J Karoukis; Lianchun Chen; Ning C McLaren; Mona Lichter; David T Wong; Peter F Hitchcock; Rafael C Caruso; Sayoko E Moroi; Irene H Maumenee; Paul Sieving
Late-onset macular degeneration and long anterior lens zonules result from a CTRP5 gene mutation.
Investigative ophthalmology & visual science 2005;46(9):3363-71.
2005: Md Nawajes A Mandal; John R Heckenlively; Tracy Burch; Lianchun Chen; Vidyullatha Vasireddy; Robert K Koenekoop; Paul Sieving; Radha Ayyagari
Sequencing arrays for screening multiple genes associated with early-onset human retinal degenerations on a high-throughput platform.
Investigative ophthalmology & visual science 2005;46(9):3355-62.
2004: Md Nawajes A Mandal; Rajesh Ambasudhan; Paul W Wong; Philip J Gage; Paul Sieving; Radha Ayyagari
Characterization of mouse orthologue of ELOVL4: genomic organization and spatial and temporal expression.
Genomics 2004;83(4):626-35.