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Silvia Mandel

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Orly Weinreb; Tamar Amit; Silvia Mandel; Moussa B H Youdim
Novel therapeutic approach for neurodegenerative pathologies: multitarget iron-chelating drugs regulating hypoxia-inducible factor 1 signal transduction pathway.
L Kupershmidt; Silvia Mandel; Orly Weinreb; Tamar Amit; Orit Bar-Am; M B H Youdim
Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain.
Orly Weinreb; Silvia Mandel; Orit Bar-Am; Tamar Amit
Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim.

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All Publications

2012: Orly Weinreb; Tamar Amit; Silvia Mandel; Moussa B H Youdim
Novel therapeutic approach for neurodegenerative pathologies: multitarget iron-chelating drugs regulating hypoxia-inducible factor 1 signal transduction pathway.
Neuro-degenerative diseases 2012;10(1-4):112-5.
2011: L Kupershmidt; Silvia Mandel; Orly Weinreb; Tamar Amit; Orit Bar-Am; M B H Youdim
Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain.
Neuroscience 2011;189():345-58.
2011: Orly Weinreb; Silvia Mandel; Orit Bar-Am; Tamar Amit
Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim.
Journal of neural transmission (Vienna, Austria : 1996) 2011;118(3):479-92.
2010: Orly Weinreb; Tamar Amit; Silvia Mandel; Lana Kupershmidt; Moussa B H Youdim
Neuroprotective multifunctional iron chelators: from redox-sensitive process to novel therapeutic opportunities.
Antioxidants & redox signaling 2010;13(6):919-49.
2010: Lana Kupershmidt; Zoya Okun; Tamar Amit; Silvia Mandel; Irena Saltsman; Atif Mahammed; Orit Bar-Am; Zeev Gross; Moussa B H Youdim
Metallocorroles as cytoprotective agents against oxidative and nitrative stress in cellular models of neurodegeneration.
Journal of neurochemistry 2010;113(2):363-73.
2010: Orit Bar-Am; Tamar Amit; Orly Weinreb; Moussa B H Youdim; Silvia Mandel
Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation.
Journal of Alzheimer's disease : JAD 2010;21(2):361-71.
2009: Orly Weinreb; Tamar Amit; Silvia Mandel; Moussa B H Youdim
Neuroprotective molecular mechanisms of (-)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties.
Genes & nutrition 2009;4(4):283-96.
2009: Zoya Okun; Lana Kupershmidt; Tamar Amit; Silvia Mandel; Orit Bar-Am; Moussa B H Youdim; Zeev Gross
Manganese corroles prevent intracellular nitration and subsequent death of insulin-producing cells.
ACS chemical biology 2009;4(11):910-4.
2009: Lana Kupershmidt; Orly Weinreb; Tamar Amit; Silvia Mandel; Maria Teresa Carri; Moussa B H Youdim
Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(11):3766-79.
2009: Orly Weinreb; Silvia Mandel; Orit Bar-Am; Merav Yogev-Falach; Yael Avramovich-Tirosh; Tamar Amit; Moussa B H Youdim
Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2009;6(1):163-74.
2008: Tamar Amit; Yael Avramovich-Tirosh; Moussa B H Youdim; Silvia Mandel
Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1296-305.
2008: Peter Riederer; Moussa B H Youdim; Silvia Mandel; Manfred Gerlach; Edna Grünblatt
Genomic aspects of sporadic Parkinson's disease.
Parkinsonism & related disorders 2008;14 Suppl 2():S88-91.
2007: Cornelis J Van Der Schyf; Silvia Mandel; Werner J Geldenhuys; Tamar Amit; Yael Avramovich; Hailin Zheng; Mati Fridkin; Shunit Gal; Orly Weinreb; Orit Bar Am; Yotam Sagi; Moussa B H Youdim
Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties.
Current Alzheimer research 2007;4(5):522-36.
2007: Silvia Mandel; Tamar Amit; Limor Kalfon; Moussa Bh Youdim
Applying transcriptomic and proteomic knowledge to Parkinson's disease drug discovery.
Expert opinion on drug discovery 2007;2(9):1225-40.
2007: Yael Avramovich-Tirosh; Lydia Reznichenko; Tamar Mit; Hailin Zheng; Mati Fridkin; Orly Weinreb; Silvia Mandel; Moussa B H Youdim
Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.
Current Alzheimer research 2007;4(4):403-11.
2007: Silvia Mandel; Tamar Amit; Orit Bar-Am; Moussa B H Youdim
Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents.
Progress in neurobiology 2007;82(6):348-60.
2007: Moussa B H Youdim; Edna Grünblatt; Silvia Mandel
The copper chelator, D-penicillamine, does not attenuate MPTP induced dopamine depletion in mice.
Journal of neural transmission (Vienna, Austria : 1996) 2007;114(2):205-9.
2007: Yotam Sagi; Silvia Mandel; Tamar Amit; Moussa B H Youdim
Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism.
Neurobiology of disease 2007;25(1):35-44.
2006: Lydia Reznichenko; Tamar Amit; Hailin Zheng; Yael Avramovich-Tirosh; Moussa B H Youdim; Orly Weinreb; Silvia Mandel
Reduction of iron-regulated amyloid precursor protein and beta-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: implications for iron chelation in Alzheimer's disease.
Journal of neurochemistry 2006;97(2):527-36.
2006: Silvia Mandel; Tamar Amit; Lydia Reznichenko; Orly Weinreb; Moussa B H Youdim
Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders.
Molecular nutrition & food research 2006;50(2):229-34.
2006: Silvia Mandel; Orly Weinreb; Lydia Reznichenko; L Kalfon; Tamar Amit
Green tea catechins as brain-permeable, non toxic iron chelators to "iron out iron" from the brain.
Journal of neural transmission. Supplementum 2006;(71):249-57.
2006: Orly Weinreb; Tamar Amit; Orit Bar-Am; Yotam Sagi; Silvia Mandel; Moussa B H Youdim
Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety.
Journal of neural transmission. Supplementum 2006;(70):457-65.
2005: Silvia Mandel; Edna Grunblatt; Peter Riederer; Ninette Amariglio; Jasmine Jacob-Hirsch; Gideon Rechavi; Moussa B H Youdim
Gene expression profiling of sporadic Parkinson's disease substantia nigra pars compacta reveals impairment of ubiquitin-proteasome subunits, SKP1A, aldehyde dehydrogenase, and chaperone HSC-70.
Annals of the New York Academy of Sciences 2005;1053():356-75.
2005: Lydia Reznichenko; Tamar Amit; Moussa B H Youdim; Silvia Mandel
Green tea polyphenol (-)-epigallocatechin-3-gallate induces neurorescue of long-term serum-deprived PC12 cells and promotes neurite outgrowth.
Journal of neurochemistry 2005;93(5):1157-67.
2005: Silvia Mandel; Orly Weinreb; Tamar Amit; Moussa B H Youdim
Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives.
Brain research. Brain research reviews 2005;48(2):379-87.
2004: Silvia Mandel; Orly Weinreb; Moussa B H Youdim
Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs.
Drug discovery today 2004;9(24 Suppl):S37-44.
2004: Edna Grünblatt; Silvia Mandel; Jasmine Jacob-Hirsch; Sharon Zeligson; N Amariglo; G Rechavi; J Li; Rivka Ravid; Wolfgang Roggendorf; Peter Riederer; Moussa B H Youdim
Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes.
Journal of neural transmission (Vienna, Austria : 1996) 2004;111(12):1543-73.
2004: Orly Weinreb; Silvia Mandel; Tamar Amit; Moussa B H Youdim
Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases.
The Journal of nutritional biochemistry 2004;15(9):506-16.
2004: Silvia Mandel; Moussa B H Youdim
Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases.
Free radical biology & medicine 2004;37(3):304-17.
2004: Silvia Mandel; Orly Weinreb; Tamar Amit; Moussa B H Youdim
Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases.
Journal of neurochemistry 2004;88(6):1555-69.
2004: Silvia Mandel; Gila Maor; Moussa B H Youdim
Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate.
Journal of molecular neuroscience : MN 2004;24(3):401-16.
2003: Yona Levites; Tamar Amit; Silvia Mandel; Moussa B H Youdim
Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(8):952-4.
2003: Silvia Mandel; Orly Weinreb; Moussa B H Youdim
Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs.
Trends in pharmacological sciences 2003;24(4):184-91.
2003: Silvia Mandel; Lydia Reznichenko; Tamar Amit; Moussa B H Youdim
Green tea polyphenol (-)-epigallocatechin-3-gallate protects rat PC12 cells from apoptosis induced by serum withdrawal independent of P13-Akt pathway.
Neurotoxicity research 2003;5(6):419-24.
2003: Silvia Mandel; Edna Grünblatt; Peter Riederer; Manfred Gerlach; Yona Levites; Moussa B H Youdim
Neuroprotective strategies in Parkinson's disease : an update on progress.
CNS drugs 2003;17(10):729-62.
2003: Silvia Mandel; Edna Grünblatt; Peter Riederer; Moussa B H Youdim
Genes and oxidative stress in parkinsonism: cDNA microarray studies.
Advances in neurology 2003;91():123-32.
2002: Silvia Mandel; Edna Grünblatt; Gila Maor; Moussa B H Youdim
Early and late gene changes in MPTP mice model of Parkinson's disease employing cDNA microarray.
Neurochemical research 2002;27(10):1231-43.
2002: Yona Levites; Tamar Amit; Moussa B H Youdim; Silvia Mandel
Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action.
The Journal of biological chemistry 2002;277(34):30574-80.
2002: Yona Levites; Moussa B H Youdim; Gila Maor; Silvia Mandel
Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures.
Biochemical pharmacology 2002;63(1):21-9.
2001: Yona Levites; O Weinreb; Gila Maor; Moussa B H Youdim; Silvia Mandel
Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration.
Journal of neurochemistry 2001;78(5):1073-82.
2001: Edna Grünblatt; Silvia Mandel; Gila Maor; Moussa B H Youdim
Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: effect of R-apomorphine.
Journal of neurochemistry 2001;78(1):1-12.
2001: Edna Grünblatt; Silvia Mandel; Gila Maor; Moussa B H Youdim
Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss.
Journal of neurochemistry 2001;77(1):146-56.
1999: Edna Grünblatt; Silvia Mandel; T Berkuzki; Moussa B H Youdim
Apomorphine protects against MPTP-induced neurotoxicity in mice.
Movement disorders : official journal of the Movement Disorder Society 1999;14(4):612-8.