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Ofer Mandelboim

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Yotam Bar-On; Ariella Glasner; Chamutal Gur; Dikla Lankry; Michal Mandelboim; Tal Meningher; Adrienne F A Meyers; Alon Vitenshtein; Hagit Achdout; Ofer Mandelboim
Neuraminidase-Mediated, NKp46-Dependent Immune-Evasion Mechanism of Influenza Viruses.
Joachim Koch; Alexander Steinle; Carsten Watzl; Ofer Mandelboim
Activating natural cytotoxicity receptors of natural killer cells in cancer and infection.
Moran Elboim; Inna Grodzovski; Esther Djian; Dana G Wolf; Ofer Mandelboim
HSV-2 specifically down regulates HLA-C expression to render HSV-2-infected DCs susceptible to NK cell killing.

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All Publications

2013: Yotam Bar-On; Ariella Glasner; Chamutal Gur; Dikla Lankry; Michal Mandelboim; Tal Meningher; Adrienne F A Meyers; Alon Vitenshtein; Hagit Achdout; Ofer Mandelboim
Neuraminidase-Mediated, NKp46-Dependent Immune-Evasion Mechanism of Influenza Viruses.
Cell reports 2013;3(4):1044-50.
2013: Joachim Koch; Alexander Steinle; Carsten Watzl; Ofer Mandelboim
Activating natural cytotoxicity receptors of natural killer cells in cancer and infection.
Trends in immunology 2013;34(4):182-91.
2013: Moran Elboim; Inna Grodzovski; Esther Djian; Dana G Wolf; Ofer Mandelboim
HSV-2 specifically down regulates HLA-C expression to render HSV-2-infected DCs susceptible to NK cell killing.
PLoS pathogens 2013;9(3):e1003226.
2013: Rossana Tallerico; Luca Tirinato; Matilde Todaro; Enzo Di Fabrizio; Simone Di Franco; Francesco Dieli; Cinzia Garofalo; Klas Kärre; Rosanna La Rocca; Cristina Maccalli; Ofer Mandelboim; Alessandro Moretta; Camillo Palmieri; Pradeepa N Pangigadde; Giorgio Parmiani; Rosa Sottile; Giorgio Stassi; Ennio Carbone
Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):2381-90.
2013: Hen Y Sela; O Singer; Tikva Turetsky; N Yachimovich-Cohen; Debra Goldman-Wohl; Caryn Greenfield; Ronit Haimov-Kochman; Yaron Hamani; Yuval Lavy; Ofer Mandelboim; Shira Natanson-Yaron; Benjamin E Reubinoff; Ariel Revel; Simcha Yagel
Human trophectoderm apposition is regulated by interferon γ-induced protein 10 (IP-10) during early implantation.
Placenta 2013;34(3):222-30.
2013: Eugenia Corrales-Aguilar; Ofer Mandelboim; Eva Mercé-Maldonado; Henrike Reinhard; Heiner Schaal; Mirko Trilling; Marek Widera; Albert Zimmermann; Hartmut Hengel
A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors.
Journal of immunological methods 2013;387(1-2):21-35.
2012: Christopher A Alvarez-Breckenridge; Michael A Caligiuri; Soledad A Fernandez; Jayson Hardcastle; Shun He; Balveen Kaur; Sean E Lawler; Ofer Mandelboim; Hsiaoyin Mao; Alessandro Moretta; Jason Pradarelli; Richard Price; Eric Vivier; Yan Wang; Min Wei; Jeffrey Wojton; Jianhua Yu; E Antonio Chiocca
NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors.
Nature medicine 2012;18(12):1827-34.
2012: Raizy Gruda; Chamutal Gur; Saar Mizrahi; Hagit Achdout; Memet Aker; Ronen Alon; Yotam Bar-On; Alice C N Brown; Daniel M Davis; Sara W Feigelson; Valentin Grabovsky; Ofer Mandelboim
Loss of kindlin-3 alters the threshold for NK cell activation in human leukocyte adhesion deficiency-III.
Blood 2012;120(19):3915-24.
2012: Pinchas Tsukerman; Alon Vitenshtein; Rachel Yamin; Daphna Nachmani; Noah Stanietsky; Noam Stern-Ginossar; Tomer Bar-Mag; Yoav Bauman; Ariella Glasner; Chamutal Gur; Dikla Lankry; Ofer Mandelboim
MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells.
Cancer research 2012;72(21):5463-72.
2012: Shlomo Elias; Ofer Mandelboim
Battle of the midgets: innate microRNA networking.
RNA biology 2012;9(6):792-8.
2012: Chamutal Gur; Elad Horwitz; Shlomit Kfir-Erenfeld; Lina Abu-Tair; Sarit Doron; Rifaat Safadi; Ofer Mandelboim
NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis.
Gut 2012;61(6):885-93.
2012: Ariella Glasner; Chamutal Gur; Jonatan Enk; Hormas Ghadially; Noa Stanietsky; Pinchas Tsukerman; Ofer Mandelboim
Recognition and prevention of tumor metastasis by the NK receptor NKp46/NCR1.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(6):2509-15.
2012: Hormas Ghadially; Yoav Keynan; Joshua Kimani; Makobu Kimani; Ofer Mandelboim; T Blake Ball; Francis A Plummer; Adrienne F A Meyers
Altered dendritic cell-natural killer interaction in Kenyan sex workers resistant to HIV-1 infection.
AIDS (London, England) 2012;26(4):429-36.
2012: Ariella Glasner; Stipan Jonjic; Tihana Lenac Rovis; Michal Mandeboim; Tal Meningher; Adrienne F A Meyers; Pinchas Tsukerman; Rachel Yamin; Antonija Zurunic; Yotam Bar-On; Ofer Mandelboim
Elucidating the mechanisms of influenza virus recognition by Ncr1.
PloS one 2012;7(5):e36837.
2012: Stella Chaushu; Moran Elboim; Chamutal Gur; Gili Halftek; Hagit Achdout; Gilad Bachrach; David Polak; Lior Shapira; Asaf Wilensky; Ofer Mandelboim
Direct recognition of Fusobacterium nucleatum by the NK cell natural cytotoxicity receptor NKp46 aggravates periodontal disease.
PLoS pathogens 2012;8(3):e1002601.
2012: Irit Manaster; Debra Goldman-Wohl; Caryn Greenfield; Yaron Hamani; Daphna Nachmani; Pinchas Tsukerman; Simcha Yagel; Ofer Mandelboim
MiRNA-mediated control of HLA-G expression and function.
PloS one 2012;7(3):e33395.
2011: Chamutal Gur; Sameer A Kassem; Judith Magenheim; Hagit Achdout; Yuval Dor; Jonatan Enk; Benjamin Glaser; Yaakov Naparstek; Tomer Nir; Angel Porgador; James Shapiro; Miri Stolovich-Rain; Yaron Suissa; Ofer Mandelboim
Recognition and killing of human and murine pancreatic beta cells by the NK receptor NKp46.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(6):3096-103.
2011: Yoav Bauman; Ofer Mandelboim
MicroRNA based immunoevasion mechanism of human polyomaviruses.
RNA biology 2011;8(4):591-4.
2011: Yoav Bauman; Daphna Nachmani; Alon Vitenshtein; Pinchas Tsukerman; Nir Drayman; Noam Stern-Ginossar; Dikla Lankry; Raizy Gruda; Ofer Mandelboim
An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination.
Cell host & microbe 2011;9(2):93-102.
2011: Shirin Elhaik-Goldman; Moshe Elkabets; Hormas Ghadially; Uzi Hadad; Luai Hulihel; Steffen Jung; Daniel Kafka; Ofer Mandelboim; Yaffa Mizrachi-Nebenzahl; Ron N Apte; Alex Braiman; Ron Dagan; Alexandra Vallon-Eberhard; Rami Yossef; Angel Porgador
The natural cytotoxicity receptor 1 contribution to early clearance of Streptococcus pneumoniae and to natural killer-macrophage cross talk.
PloS one 2011;6(8):e23472.
2010: Noa Stanietsky; Ofer Mandelboim
Paired NK cell receptors controlling NK cytotoxicity.
FEBS letters 2010;584(24):4895-900.
2010: Daphna Nachmani; Dikla Lankry; Dana G Wolf; Ofer Mandelboim
The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination.
Nature immunology 2010;11(9):806-13.
2010: Dikla Lankry; Hrvoje Simic; Yair Klieger; Francesca Levi-Schaffer; Stipan Jonjic; Ofer Mandelboim
Expression and function of CD300 in NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(5):2877-86.
2010: Irit Manaster; Ofer Mandelboim
The unique properties of uterine NK cells.
American journal of reproductive immunology (New York, N.Y. : 1989) 2010;63(6):434-44.
2010: Moran Elboim; Roi Gazit; Chamutal Gur; Hormas Ghadially; Gili Betser-Cohen; Ofer Mandelboim
Tumor immunoediting by NKp46.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(10):5637-44.
2010: Michal Mendelson; Yoram Tekoah; Alon Zilka; Orly Gershoni-Yahalom; Roi Gazit; Hagit Achdout; Nicolai V Bovin; Tal Meningher; Michal Mandelboim; Ofer Mandelboim; Ayelet David; Angel Porgador
NKp46 O-glycan sequences that are involved in the interaction with hemagglutinin type 1 of influenza virus.
Journal of virology 2010;84(8):3789-97.
2010: Hagit Achdout; Tal Meningher; Shira Hirsh; Ariella Glasner; Yotam Bar-On; Chamutal Gur; Angel Porgador; Michal Mendelson; Michal Mandelboim; Ofer Mandelboim
Killing of avian and Swine influenza virus by natural killer cells.
Journal of virology 2010;84(8):3993-4001.
2010: Gili Betser-Cohen; Saar Mizrahi; Moran Elboim; Osnat Alsheich-Bartok; Ofer Mandelboim
The association of MHC class I proteins with the 2B4 receptor inhibits self-killing of human NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(6):2761-8.
2010: Chamutal Gur; Angel Porgador; Moran Elboim; Roi Gazit; Saar Mizrahi; Noam Stern-Ginossar; Hagit Achdout; Hormas Ghadially; Yuval Dor; Tomer Nir; Victoria Doviner; Oren Hershkovitz; Michal Mendelson; Yaakov Naparstek; Ofer Mandelboim
The activating receptor NKp46 is essential for the development of type 1 diabetes.
Nature immunology 2010;11(2):121-8.
2010: Tsufit Gonen-Gross; Debra Goldman-Wohl; Berthold Huppertz; Dikla Lankry; Caryn Greenfield; Shira Natanson-Yaron; Yaron Hamani; Ronit Gilad; Simcha Yagel; Ofer Mandelboim
Inhibitory NK receptor recognition of HLA-G: regulation by contact residues and by cell specific expression at the fetal-maternal interface.
PloS one 2010;5(1):e8941.
2010: Dikla Lankry; Roi Gazit; Ofer Mandelboim
Methods to identify and characterize different NK cell receptors and their ligands.
Methods in molecular biology (Clifton, N.J.) 2010;612():249-73.
2010: Irit Manaster; Roi Gazit; Debra Goldman-Wohl; Noam Stern-Ginossar; Sa'ar Mizrahi; Simcha Yagel; Ofer Mandelboim
Notch activation enhances IFNgamma secretion by human peripheral blood and decidual NK cells.
Journal of reproductive immunology 2010;84(1):1-7.
2009: Naoko Satoh-Takayama; Laure Dumoutier; Sarah Lesjean-Pottier; Vera S G Ribeiro; Ofer Mandelboim; Jean-Christophe Renauld; Christian A J Vosshenrich; James P Di Santo
The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(10):6579-87.
2009: Noa Stanietsky; Hrvoje Simic; Jurica Arapovic; Amir Toporik; Ofer Levy; Amit Novik; Zurit Levine; Merav Beiman; Liat Dassa; Hagit Achdout; Noam Stern-Ginossar; Pinhas Tsukerman; Stipan Jonjic; Ofer Mandelboim
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17858-63.
2009: Hélène Beuneu; Jacques Deguine; Béatrice Breart; Ofer Mandelboim; James P Di Santo; Philippe Bousso
Dynamic behavior of NK cells during activation in lymph nodes.
Blood 2009;114(15):3227-34.
2009: Noam Stern-Ginossar; Niveen Saleh; Miri D Goldberg; Mark Prichard; Dana G Wolf; Ofer Mandelboim
Analysis of human cytomegalovirus-encoded microRNA activity during infection.
Journal of virology 2009;83(20):10684-93.
2009: Noam Stern-Ginossar; Ofer Mandelboim
An integrated view of the regulation of NKG2D ligands.
Immunology 2009;128(1):1-6.
2009: Daphna Nachmani; Noam Stern-Ginossar; Ronit Sarid; Ofer Mandelboim
Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells.
Cell host & microbe 2009;5(4):376-85.
2009: Gili G Halfteck; Moran Elboim; Chamutal Gur; Hagit Achdout; Hormas Ghadially; Ofer Mandelboim
Enhanced in vivo growth of lymphoma tumors in the absence of the NK-activating receptor NKp46/NCR1.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):2221-30.
2008: Noam Stern-Ginossar; Chamutal Gur; Moshe Biton; Elad Horwitz; Moran Elboim; Noa Stanietsky; Michal Mandelboim; Ofer Mandelboim
Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D.
Nature immunology 2008;9(9):1065-73.
2008: Irit Manaster; Sa'ar Mizrahi; Debra Goldman-Wohl; Hen Y Sela; Noam Stern-Ginossar; Dikla Lankry; Raizy Gruda; Arye Hurwitz; Yuval Bdolah; Ronit Haimov-Kochman; Simcha Yagel; Ofer Mandelboim
Endometrial NK cells are special immature cells that await pregnancy.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1869-76.
2008: Hagit Achdout; Irit Manaster; Ofer Mandelboim
Influenza virus infection augments NK cell inhibition through reorganization of major histocompatibility complex class I proteins.
Journal of virology 2008;82(16):8030-7.
2008: Roi Gazit; K Hershko; A Ingbar; M Schlesinger; Shoshana Israel; Chaim Brautbar; Ofer Mandelboim; V Leibovici
Immunological assessment of familial tinea corporis.
Journal of the European Academy of Dermatology and Venereology : JEADV 2008;22(7):871-4.
2008: Emanuela Cagnano; Oren Hershkovitz; Alon Zilka; Ahuva Bar-Ilan; Alexandra Golder; Netta Sion-Vardy; Alexander Bogdanov-Berezovsky; Ofer Mandelboim; Daniel Benharroch; Angel Porgador
Expression of ligands to NKp46 in benign and malignant melanocytes.
The Journal of investigative dermatology 2008;128(4):972-9.
2008: Joanna W Ho; Oren Hershkovitz; Malik Peiris; Alon Zilka; Ahuva Bar-Ilan; Beatrice Nal; Kid Chu; Mateusz Kudelko; Yiu Wing Kam; Hagit Achdout; Michal Mandelboim; Ralf Altmeyer; Ofer Mandelboim; Roberto Bruzzone; Angel Porgador
H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44.
Journal of virology 2008;82(4):2028-32.
2008: Tal I Arnon; Gal Markel; Ahuva Bar-Ilan; Jacob Hanna; Eyal Fima; Fabrice Benchetrit; Ruth Galili; Adelheid Cerwenka; Daniel Benharroch; Netta Sion-Vardy; Angel Porgador; Ofer Mandelboim
Harnessing soluble NK cell killer receptors for the generation of novel cancer immune therapy.
PloS one 2008;3(5):e2150.
2008: Oren Hershkovitz; Mostafa Jarahian; Alon Zilka; Ahuva Bar-Ilan; Guy Landau; Sergey Jivov; Yoram Tekoah; Rachel Glicklis; John T Gallagher; Sabrina C Hoffmann; Hagit Zer; Ofer Mandelboim; Carsten Watzl; Frank Momburg; Angel Porgador
Altered glycosylation of recombinant NKp30 hampers binding to heparan sulfate: a lesson for the use of recombinant immunoreceptors as an immunological tool.
Glycobiology 2008;18(1):28-41.
2007: Boaz Nachmias; Sa'ar Mizrahi; Meital Elmalech; Itay Lazar; Yaqoub Ashhab; Roi Gazit; Gal Markel; Dina Ben-Yehuda; Ofer Mandelboim
Manipulation of NK cytotoxicity by the IAP family member Livin.
European journal of immunology 2007;37(12):3467-76.
2007: Vladimir Yutkin; Dov Pode; Eli Pikarsky; Ofer Mandelboim
The expression level of ligands for natural killer cell receptors predicts response to bacillus Calmette-Guerin therapy: a pilot study.
The Journal of urology 2007;178(6):2660-4.
2007: Sa'ar Mizrahi; Eitan Yefenof; Menahem Gross; Pierre Attal; Abraham Ben-Yaakov; Debra Goldman-Wohl; Bella Maly; Noam Stern; Gil Katz; Roi Gazit; Ronit Sionov; Ofer Mandelboim; Stella Chaushu
A phenotypic and functional characterization of NK cells in adenoids.
Journal of leukocyte biology 2007;82(5):1095-105.
2007: Christian A J Vosshenrich; Sarah Lesjean-Pottier; Milena Hasan; Odile Richard-Le Goff; Erwan Corcuff; Ofer Mandelboim; James P Di Santo
CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells.
The Journal of experimental medicine 2007;204(11):2569-78.
2007: Noam Stern-Ginossar; Shlomo Nedvetzki; Gal Markel; Roi Gazit; Gili Betser-Cohen; Hagit Achdout; Memet Aker; Richard S Blumberg; Daniel M Davis; Ben J Appelmelk; Ofer Mandelboim
Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4424-34.
2007: Raizy Gruda; Hagit Achdout; Noam Stern-Ginossar; Roi Gazit; Gili Betser-Cohen; Irit Manaster; Gil Katz; Tsufit Gonen-Gross; Boaz Tirosh; Ofer Mandelboim
Intracellular cysteine residues in the tail of MHC class I proteins are crucial for extracellular recognition by leukocyte Ig-like receptor 1.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3655-61.
2007: Hannah S W Lee; Ian C Boulton; Karen Reddin; Henry Wong; Denise Halliwell; Ofer Mandelboim; Andrew R Gorringe; Scott D Gray-Owen
Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function.
Infection and immunity 2007;75(9):4449-55.
2007: Noam Stern-Ginossar; Naama Elefant; Albert Zimmermann; Dana G Wolf; Niveen Saleh; Moshe Biton; Elad Horwitz; Zafnat Prokocimer; Mark Prichard; Gabriele Hahn; Debra Goldman-Wohl; Caryn Greenfield; Simcha Yagel; Hartmut Hengel; Yael Altuvia; Hanah Margalit; Ofer Mandelboim
Host immune system gene targeting by a viral miRNA.
Science (New York, N.Y.) 2007;317(5836):376-81.
2007: Boaz Nachmias; Itay Lazar; Meital Elmalech; Ihab Abed-El-Rahaman; Yaqoub Asshab; Ofer Mandelboim; Riki Perlman; Dina Ben-Yehuda
Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin.
Apoptosis : an international journal on programmed cell death 2007;12(7):1129-42.
2007: Roi Gazit; Memet Aker; Moran Elboim; Hagit Achdout; Gil Katz; Dana G Wolf; Shulamit Katzav; Ofer Mandelboim
NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome.
Blood 2007;109(10):4306-12.
2007: Jacob Hanna; Ofer Mandelboim
When killers become helpers.
Trends in immunology 2007;28(5):201-6.
2007: Tsufit Gonen-Gross; Ofer Mandelboim
HLA-G complexes are observed on the cell surface.
Human immunology 2007;68(4):227-32.
2007: Sa'ar Mizrahi; Gal Markel; Angel Porgador; Yuri Bushkin; Ofer Mandelboim
CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72.
PloS one 2007;2(9):e818.
2006: Qigui Yu; Edith M C Chow; Henry Wong; Jenny Gu; Ofer Mandelboim; Scott D Gray-Owen; Mario A Ostrowski
CEACAM1 (CD66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and AKT-dependent pathway.
The Journal of biological chemistry 2006;281(51):39179-93.
2006: Gal Markel; Rachel Seidman; Noam Stern; Tali Cohen-Sinai; Orit Izhaki; Gil Katz; Michal Besser; Avraham J Treves; Richard S Blumberg; Ron Loewenthal; Ofer Mandelboim; Arie Orenstein; Jacob Schachter
Inhibition of human tumor-infiltrating lymphocyte effector functions by the homophilic carcinoembryonic cell adhesion molecule 1 interactions.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6062-71.
2006: Tal I Arnon; Gal Markel; Ofer Mandelboim
Tumor and viral recognition by natural killer cells receptors.
Seminars in cancer biology 2006;16(5):348-58.
2006: Jacob Hanna; Debra Goldman-Wohl; Yaron Hamani; Inbal Avraham; Caryn Greenfield; Shira Natanson-Yaron; Diana Prus; Leonor Daniel; Tal I Arnon; Irit Manaster; Roi Gazit; Vladimir Yutkin; Daniel Benharroch; Angel Porgador; Eli Keshet; Simcha Yagel; Ofer Mandelboim
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface.
Nature medicine 2006;12(9):1065-74.
2006: Gili Betser-Cohen; Gil Katz; Tsufit Gonen-Gross; Noam Stern; Tal I Arnon; Hagit Achdout; Roi Gazit; Ofer Mandelboim
Reduced KIR2DL1 recognition of MHC class I molecules presenting phosphorylated peptides.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6762-9.
2006: Roi Gazit; Raizy Gruda; Moran Elboim; Tal I Arnon; Gil Katz; Hagit Achdout; Jacob Hanna; Udi Qimron; Guy Landau; Evgenia Greenbaum; Zichria Zakay-Rones; Angel Porgador; Ofer Mandelboim
Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1.
Nature immunology 2006;7(5):517-23.
2006: Micha Drukker; Helena Katchman; Gil Katz; Smadar Even-Tov Friedman; Elias Shezen; Eran Hornstein; Ofer Mandelboim; Yair Reisner; Nissim Benvenisty
Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells.
Stem cells (Dayton, Ohio) 2006;24(2):221-9.
2005: Jacob Hanna; Huda Mussaffi; Guy Steuer; Suhair Hanna; Maher Deeb; Hannah Blau; Tal I Arnon; Noam Weizman; Ofer Mandelboim
Functional aberrant expression of CCR2 receptor on chronically activated NK cells in patients with TAP-2 deficiency.
Blood 2005;106(10):3465-73.
2005: Tsufit Gonen-Gross; Hagit Achdout; Tal I Arnon; Roi Gazit; Noam Stern; Václav Horejsí; Debra Goldman-Wohl; Simcha Yagel; Ofer Mandelboim
The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):4866-74.
2005: Niva Azuz-Lieberman; Gal Markel; Sa'ar Mizrahi; Roi Gazit; Jacob Hanna; Hagit Achdout; Raizy Gruda; Gil Katz; Tal I Arnon; Shosh Battat; Ehud Zamir; Muhammed Adawi; Reuven Mader; Ofer Mandelboim
The involvement of NK cells in ankylosing spondylitis.
International immunology 2005;17(7):837-45.
2005: Noam Stern; Gal Markel; Tal I Arnon; Raizy Gruda; Henry Wong; Scott D Gray-Owen; Ofer Mandelboim
Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):6692-701.
2005: Tal I Arnon; Hagit Achdout; Ofer Levi; Gal Markel; Niveen Saleh; Gil Katz; Roi Gazit; Tsufit Gonen-Gross; Jacob Hanna; Efrat Nahari; Angel Porgador; Alik Honigman; Bodo Plachter; Dror Mevorach; Dana G Wolf; Ofer Mandelboim
Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus.
Nature immunology 2005;6(5):515-23.
2005: Jacob Hanna; Jonathan Fitchett; Tony Rowe; Mark Daniels; Melissa Heller; Tsufit Gonen-Gross; Efrat Manaster; Samuel Y Cho; Michael J LaBarre; Ofer Mandelboim
Proteomic analysis of human natural killer cells: insights on new potential NK immune functions.
Molecular immunology 2005;42(4):425-31.
2005: Ariel Munitz; Ido Bachelet; Shira Fraenkel; Gil Katz; Ofer Mandelboim; Hans-Uwe Simon; Lorenzo Moretta; Marco COLONna; Francesca Levi-Schaffer
2B4 (CD244) is expressed and functional on human eosinophils.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):110-8.
2004: Jacob Hanna; Tsufit Gonen-Gross; Jonathan Fitchett; Tony Rowe; Mark Daniels; Tal I Arnon; Roi Gazit; Aviva Joseph; Karoline W Schjetne; Alexander Steinle; Angel Porgador; Dror Mevorach; Debra Goldman-Wohl; Simcha Yagel; Michael J LaBarre; Jane H Buckner; Ofer Mandelboim
Novel APC-like properties of human NK cells directly regulate T cell activation.
The Journal of clinical investigation 2004;114(11):1612-23.
2004: Jacob Hanna; Pamela Bechtel; Yufeng Zhai; Fadi Youssef; Karen McLachlan; Ofer Mandelboim
Novel insights on human NK cells' immunological modalities revealed by gene expression profiling.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6547-63.
2004: Gal Markel; Raizy Gruda; Hagit Achdout; Gil Katz; Morris Nechama; Richard S Blumberg; Robert Kammerer; Wolfgang Zimmermann; Ofer Mandelboim
The critical role of residues 43R and 44Q of carcinoembryonic antigen cell adhesion molecules-1 in the protection from killing by human NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3732-9.
2004: Gil Katz; Roi Gazit; Tal I Arnon; Tsufit Gonen-Gross; Gabi Tarcic; Gal Markel; Raizy Gruda; Hagit Achdout; Olga Drize; Sharon Merims; Ofer Mandelboim
MHC class I-independent recognition of NK-activating receptor KIR2DS4.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1819-25.
2004: Gal Markel; Hagit Achdout; Gil Katz; Khoon-Lin Ling; Mariolina Salio; Raizy Gruda; Roi Gazit; Sa'ar Mizrahi; Jacob Hanna; Tsufit Gonen-Gross; Tal I Arnon; Niva Lieberman; Noam Stren; Boaz Nachmias; Richard S Blumberg; Guy Steuer; Hannah Blau; Vincenzo Cerundolo; Huda Mussaffi; Ofer Mandelboim
Biological function of the soluble CEACAM1 protein and implications in TAP2-deficient patients.
European journal of immunology 2004;34(8):2138-48.
2004: Roi Gazit; Hagai Rechnitzer; Hagit Achdout; Avigail Katzenell; Gil Katz; Gal Markel; Tal I Arnon; Tsufit Gonen-Gross; Sa'ar Mizrahi; Raizy Gruda; Shlomo Rottem; Ofer Mandelboim
Recognition of Mycoplasma hyorhinis by CD99-Fc molecule.
European journal of immunology 2004;34(7):2032-40.
2004: Lola Weiss; Shoshana Reich; Ofer Mandelboim; Shimon Slavin
Murine B-cell leukemia lymphoma (BCL1) cells as a target for NK cell-mediated immunotherapy.
Bone marrow transplantation 2004;33(11):1137-41.
2004: Ori Wald; Orit Pappo; Rifaat Safadi; Michal Dagan-Berger; Katia Beider; Hanna Wald; Suzanna Franitza; Ido D Weiss; Shani Avniel; Pal Boaz; Jacob Hanna; Gideon Zamir; Ahmed Eid; Ofer Mandelboim; Ulrich Spengler; Eithan Galun; Amnon Peled
Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus.
European journal of immunology 2004;34(4):1164-74.
2004: Roi Gazit; Ben-Zion Garty; Yehudit Monselise; Vered Hoffer; Yaron Finkelstein; Gal Markel; Gil Katz; Jacob Hanna; Hagit Achdout; Raizy Gruda; Tsufit Gonen-Gross; Ofer Mandelboim
Expression of KIR2DL1 on the entire NK cell population: a possible novel immunodeficiency syndrome.
Blood 2004;103(5):1965-6.
2004: Gal Markel; Huda Mussaffi; Khoon-Lin Ling; Mariolina Salio; Stephan D Gadola; Guy Steuer; Hannah Blau; Hagit Achdout; María de Miguel; Tsufit Gonen-Gross; Jacob Hanna; Tal I Arnon; Udi Qimron; Ilan Volovitz; Lea Eisenbach; Richard S Blumberg; Angel Porgador; Vincenzo Cerundolo; Ofer Mandelboim
The mechanisms controlling NK cell autoreactivity in TAP2-deficient patients.
Blood 2004;103(5):1770-8.
2004: Tal I Arnon; Hagit Achdout; Niva Lieberman; Roi Gazit; Tsufit Gonen-Gross; Gil Katz; Ahuva Bar-Ilan; Noga Bloushtain; Marianna Lev; Aviva Joseph; Eli Kedar; Angel Porgador; Ofer Mandelboim
The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46.
Blood 2004;103(2):664-72.
2003: Tsufit Gonen-Gross; Roi Gazit; Hagit Achdout; Jacob Hanna; Sa'ar Mizrahi; Gal Markel; Václav Horejsí; Ofer Mandelboim
Special organization of the HLA-G protein on the cell surface.
Human immunology 2003;64(11):1011-6.
2003: Boaz Nachmias; Yaqoub Ashhab; Vered Bucholtz; Olga Drize; Luna Kadouri; Michal Lotem; Tamar Peretz; Ofer Mandelboim; Dina Ben-Yehuda
Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma.
Cancer research 2003;63(19):6340-9.
2003: Katia Beider; Arnon Nagler; Ori Wald; Suzanna Franitza; Michal Dagan-Berger; Hanna Wald; Hilla Giladi; Stefan Brocke; Jacob Hanna; Ofer Mandelboim; Merav Darash-Yahana; Eithan Galun; Amnon Peled
Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice.
Blood 2003;102(6):1951-8.
2003: Jacob Hanna; Ori Wald; Debra Goldman-Wohl; Diana Prus; Gal Markel; Roi Gazit; Gil Katz; Ronit Haimov-Kochman; Nobutaka Fujii; Simcha Yagel; Amnon Peled; Ofer Mandelboim
CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells.
Blood 2003;102(5):1569-77.
2003: Yuzhi Dong; Jaroslava Lieskovska; Dmitriy Kedrin; Steven A Porcelli; Ofer Mandelboim; Yuri Bushkin
Soluble nonclassical HLA generated by the metalloproteinase pathway.
Human immunology 2003;64(8):802-10.
2003: Tsufit Gonen-Gross; Hagit Achdout; Roi Gazit; Jacob Hanna; Sa'ar Mizrahi; Gal Markel; Debra Goldman-Wohl; Simcha Yagel; Václav Horejsí; Ofer Levy; Michal Baniyash; Ofer Mandelboim
Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1343-51.
2003: Hagit Achdout; Tal I Arnon; Gal Markel; Tsufit Gonen-Gross; Gil Katz; Niva Lieberman; Roi Gazit; Aviva Joseph; Eli Kedar; Ofer Mandelboim
Enhanced recognition of human NK receptors after influenza virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):915-23.
2002: Gal Markel; Dana Wolf; Jacob Hanna; Roi Gazit; Debra Goldman-Wohl; Yuval Lavy; Simcha Yagel; Ofer Mandelboim
Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions.
The Journal of clinical investigation 2002;110(7):943-53.
2002: Micha Drukker; Gil Katz; Achia Urbach; Maya Schuldiner; Gal Markel; Joseph Itskovitz-Eldor; Benjamin E Reubinoff; Ofer Mandelboim; Nissim Benvenisty
Characterization of the expression of MHC proteins in human embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9864-9.
2002: Ramakrishna Vankayalapati; Benjamin Wizel; Stephen E Weis; Hassan Safi; David L Lakey; Ofer Mandelboim; Buka Samten; Angel Porgador; Peter F Barnes
The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3451-7.
2002: Gal Markel; Niva Lieberman; Gil Katz; Tal I Arnon; Michal Lotem; Olga Drize; Richard S Blumberg; Erez Bar-Haim; Reuven Mader; Lea Eisenbach; Ofer Mandelboim
CD66a interactions between human melanoma and NK cells: a novel class I MHC-independent inhibitory mechanism of cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2803-10.
2002: Pamela Tan; Harald Kropshofer; Ofer Mandelboim; Nadja Bulbuc; Günter J Hämmerling; Frank Momburg
Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1950-60.
2001: Ofer Mandelboim; Angel Porgador
NKp46.
The international journal of biochemistry & cell biology 2001;33(12):1147-50.
2001: Tal I Arnon; Marianna Lev; Gil Katz; Y Chernobrov; Angel Porgador; Ofer Mandelboim
Recognition of viral hemagglutinins by NKp44 but not by NKp30.
European journal of immunology 2001;31(9):2680-9.
2001: Gil Katz; Gal Markel; Sa'ar Mizrahi; Tal I Arnon; Ofer Mandelboim
Recognition of HLA-Cw4 but not HLA-Cw6 by the NK cell receptor killer cell Ig-like receptor two-domain short tail number 4.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7260-7.
2001: Ofer Mandelboim; Niva Lieberman; Marianna Lev; L Paul; Tal I Arnon; Yuri Bushkin; D M Davis; Jack L Strominger; jon yewdell; Angel Porgador
Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells.
Nature 2001;409(6823):1055-60.
2000: Niva Lieberman; Ofer Mandelboim
The role of NK cells in innate immunity.
Advances in experimental medicine and biology 2000;479():137-45.
1997: Ofer Mandelboim; Erez Bar-Haim; Ezra Vadai; Mati Fridkin; Lea Eisenbach
Identification of shared tumor-associated antigen peptides between two spontaneous lung carcinomas.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6030-6.
1997: Ofer Mandelboim; G Berke; M Fridkin; M Feldman; M Eisenstein; Lea Eisenbach
Correction. CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma.
Nature 1997;390(6660):643.
1997: Angel Porgador; Ofer Mandelboim; N P Restifo; Jack L Strominger
Natural killer cell lines kill autologous beta2-microglobulin-deficient melanoma cells: implications for cancer immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13140-5.
1995: Ofer Mandelboim; Ezra Vadai; M Feldman; Lea Eisenbach
Expression of two H-2K genes, syngeneic and allogeneic, as a strategy for potentiating immune recognition of tumor cells.
Gene therapy 1995;2(10):757-65.
1995: Ofer Mandelboim; Ezra Vadai; Mati Fridkin; A Katz-Hillel; M Feldman; G Berke; Lea Eisenbach
Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides.
Nature medicine 1995;1(11):1179-83.
1994: Ofer Mandelboim; G Berke; Mati Fridkin; M Feldman; Miriam Eisenstein; Lea Eisenbach
CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma.
Nature 1994;369(6475):67-71.
1992: Ofer Mandelboim; M Feldman; Lea Eisenbach
H-2K double transfectants of tumor cells as antimetastatic cellular vaccines in heterozygous recipients. Implications for the T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(11):3666-73.