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Christian Mandl

Research Profile

Living Beings

Chemicals & Drugs

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Anatomy

Cell Line

Disorders

Encephalitis, Tick-Borne

Genes & Molecular Sequences

Physiology

Mutation

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Cloning, Molecular

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Publications

TOP 3
Sabrina Schrauf; Martina Kurz; Christian W Mandl; Christian Taucher; Tim Skern
Generation and genetic stability of tick-borne encephalitis virus mutants dependent on processing by the foot-and-mouth disease virus 3C protease.
Harald Rouha; Caroline Thurner; Verena M Hoenninger; Christian W Mandl
Mutational analysis of three predicted 5'-proximal stem-loop structures in the genome of tick-borne encephalitis virus indicates different roles in RNA replication and translation.
Harald Rouha; Caroline Thurner; Christian W Mandl
Functional microRNA generated from a cytoplasmic RNA virus.

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All Publications

2012: Sabrina Schrauf; Martina Kurz; Christian W Mandl; Christian Taucher; Tim Skern
Generation and genetic stability of tick-borne encephalitis virus mutants dependent on processing by the foot-and-mouth disease virus 3C protease.
The Journal of general virology 2012;93(Pt 3):504-15.
2011: Harald Rouha; Caroline Thurner; Verena M Hoenninger; Christian W Mandl
Mutational analysis of three predicted 5'-proximal stem-loop structures in the genome of tick-borne encephalitis virus indicates different roles in RNA replication and translation.
Virology 2011;417(1):79-86.
2010: Harald Rouha; Caroline Thurner; Christian W Mandl
Functional microRNA generated from a cytoplasmic RNA virus.
Nucleic acids research 2010;38(22):8328-37.
2009: Sabrina Schrauf; Christian W Mandl; Lesley Bell-Sakyi; Tim Skern
Extension of flavivirus protein C differentially affects early RNA synthesis and growth in mammalian and arthropod host cells.
Journal of virology 2009;83(21):11201-10.
2008: Wolfgang Fischl; Sigrid Elshuber; Sabrina Schrauf; Christian W Mandl
Changing the protease specificity for activation of a flavivirus, tick-borne encephalitis virus.
Journal of virology 2008;82(17):8272-82.
2008: Verena M Hoenninger; Harald Rouha; Klaus Orlinger; Lisa Miorin; Alessandro Marcello; Regina M Kofler; Christian W Mandl
Analysis of the effects of alterations in the tick-borne encephalitis virus 3'-noncoding region on translation and RNA replication using reporter replicons.
Virology 2008;377(2):419-30.
2008: Sabrina Schrauf; Petra Schlick; Tim Skern; Christian W Mandl
Functional analysis of potential carboxy-terminal cleavage sites of tick-borne encephalitis virus capsid protein.
Journal of virology 2008;82(5):2218-29.
2007: Klaus Orlinger; Regina M Kofler; Franz X Heinz; Verena M Hoenninger; Christian W Mandl
Selection and analysis of mutations in an encephalomyocarditis virus internal ribosome entry site that improve the efficiency of a bicistronic flavivirus construct.
Journal of virology 2007;81(22):12619-29.
2006: Klaus Orlinger; Verena M Hoenninger; Regina M Kofler; Christian W Mandl
Construction and mutagenesis of an artificial bicistronic tick-borne encephalitis virus genome reveals an essential function of the second transmembrane region of protein e in flavivirus assembly.
Journal of virology 2006;80(24):12197-208.
2006: Regina M Kofler; Verena M Hoenninger; Caroline Thurner; Christian W Mandl
Functional analysis of the tick-borne encephalitis virus cyclization elements indicates major differences between mosquito-borne and tick-borne flaviviruses.
Journal of virology 2006;80(8):4099-113.
2005: Judith H Aberle; Stephan W Aberle; Regina M Kofler; Christian W Mandl
Humoral and cellular immune response to RNA immunization with flavivirus replicons derived from tick-borne encephalitis virus.
Journal of virology 2005;79(24):15107-13.
2005: Sigrid Elshuber; Christian W Mandl
Resuscitating mutations in a furin cleavage-deficient mutant of the flavivirus tick-borne encephalitis virus.
Journal of virology 2005;79(18):11813-23.
2005: Christian W Mandl
Steps of the tick-borne encephalitis virus replication cycle that affect neuropathogenesis.
Virus research 2005;111(2):161-74.
2005: Rainer Gehrke; Franz X Heinz; Nancy L Davis; Christian W Mandl
Heterologous gene expression by infectious and replicon vectors derived from tick-borne encephalitis virus and direct comparison of this flavivirus system with an alphavirus replicon.
The Journal of general virology 2005;86(Pt 4):1045-53.
2004: Remi CHARREL; Houssam Attoui; A M Butenko; J C Clegg; V Deubel; TV Frolova; Ernest A Gould; Tamara S Gritsun; Franz X Heinz; M Labuda; VA Lashkevich; Valery B Loktev; A Lundkvist; D V Lvov; Christian W Mandl; M Niedrig; Anna Papa; V S Petrov; A Plyusnin; S Randolph; Jochen Süss; V I Zlobin; Xavier de Lamballerie
Tick-borne virus diseases of human interest in Europe.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2004;10(12):1040-55.
2004: Stefan Kiermayr; Regina M Kofler; Christian W Mandl; Paul Messner; Franz X Heinz
Isolation of capsid protein dimers from the tick-borne encephalitis flavivirus and in vitro assembly of capsid-like particles.
Journal of virology 2004;78(15):8078-84.
2004: Regina M Kofler; Judith H Aberle; Stephan W Aberle; Steven L Allison; Franz X Heinz; Christian W Mandl
Mimicking live flavivirus immunization with a noninfectious RNA vaccine.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1951-6.
2004: Christian W Mandl
Flavivirus immunization with capsid-deletion mutants: basics, benefits, and barriers.
Viral immunology 2004;17(4):461-72.
2004: Regina M Kofler; Franz X Heinz; Christian W Mandl
A novel principle of attenuation for the development of new generation live flavivirus vaccines.
Archives of virology. Supplementum 2004;(18):191-200.
2003: Steven L Allison; Yizhi J Tao; Gabriel O'Riordain; Christian W Mandl; Stephen C Harrison; Franz X Heinz
Two distinct size classes of immature and mature subviral particles from tick-borne encephalitis virus.
Journal of virology 2003;77(21):11357-66.
2003: Rainer Gehrke; Michael Ecker; Stephan W Aberle; Steven L Allison; Franz X Heinz; Christian W Mandl
Incorporation of tick-borne encephalitis virus replicons into virus-like particles by a packaging cell line.
Journal of virology 2003;77(16):8924-33.
2003: Helga Kroschewski; Steven L Allison; Franz X Heinz; Christian W Mandl
Role of heparan sulfate for attachment and entry of tick-borne encephalitis virus.
Virology 2003;308(1):92-100.
2003: Sigrid Elshuber; Steven L Allison; Franz X Heinz; Christian W Mandl
Cleavage of protein prM is necessary for infection of BHK-21 cells by tick-borne encephalitis virus.
The Journal of general virology 2003;84(Pt 1):183-91.
2003: Regina M Kofler; Agnes Leitner; Gabriel O'Riordain; Franz X Heinz; Christian W Mandl
Spontaneous mutations restore the viability of tick-borne encephalitis virus mutants with large deletions in protein C.
Journal of virology 2003;77(1):443-51.
2002: Regina M Kofler; Franz X Heinz; Christian W Mandl
Capsid protein C of tick-borne encephalitis virus tolerates large internal deletions and is a favorable target for attenuation of virulence.
Journal of virology 2002;76(7):3534-43.
2001: Karin Stiasny; Steven L Allison; Christian W Mandl; Franz X Heinz
Role of metastability and acidic pH in membrane fusion by tick-borne encephalitis virus.
Journal of virology 2001;75(16):7392-8.
2001: Christian W Mandl; Helga Kroschewski; Steven L Allison; Regina M Kofler; Heidemarie Holzmann; T Meixner; Franz X Heinz
Adaptation of tick-borne encephalitis virus to BHK-21 cells results in the formation of multiple heparan sulfate binding sites in the envelope protein and attenuation in vivo.
Journal of virology 2001;75(12):5627-37.
2001: Steven L Allison; Juliane Schalich; Karin Stiasny; Christian W Mandl; Franz X Heinz
Mutational evidence for an internal fusion peptide in flavivirus envelope protein E.
Journal of virology 2001;75(9):4268-75.
2000: Christian W Mandl; Steven L Allison; Heidemarie Holzmann; T Meixner; Franz X Heinz
Attenuation of tick-borne encephalitis virus by structure-based site-specific mutagenesis of a putative flavivirus receptor binding site.
Journal of virology 2000;74(20):9601-9.
2000: Elisabeth Puchhammer-Stöckl; Christian W Mandl; Josef Kletzmayr; Heidemarie Holzmann; A Hofmann; Stephan W Aberle; Franz X Heinz; Bruno Watschinger; H Hofmann
Monitoring the virus load can predict the emergence of drug-resistant hepatitis B virus strains in renal transplantation patients during lamivudine therapy.
The Journal of infectious diseases 2000;181(6):2063-6.
1999: Judith H Aberle; Stephan W Aberle; Steven L Allison; Karin Stiasny; Michael Ecker; Christian W Mandl; R Berger; Franz X Heinz
A DNA immunization model study with constructs expressing the tick-borne encephalitis virus envelope protein E in different physical forms.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6756-61.
1999: Judith H Aberle; Stephan W Aberle; M N Dworzak; Christian W Mandl; Winfried Rebhandl; G Vollnhofer; Michael Kundi; Theresia Popow-Kraupp
Reduced interferon-gamma expression in peripheral blood mononuclear cells of infants with severe respiratory syncytial virus disease.
American journal of respiratory and critical care medicine 1999;160(4):1263-8.
1999: Steven L Allison; Karin Stiasny; Konrad Stadler; Christian W Mandl; Franz X Heinz
Mapping of functional elements in the stem-anchor region of tick-borne encephalitis virus envelope protein E.
Journal of virology 1999;73(7):5605-12.
1999: Elisabeth Puchhammer-Stöckl; Brigitte Schmied; Christian W Mandl; Norbert Vetter; Franz X Heinz
Comparison of line probe assay (LIPA) and sequence analysis for detection of HIV-1 drug resistance.
Journal of medical virology 1999;57(3):283-9.
1998: Christian W Mandl; Judith H Aberle; Stephan W Aberle; Heidemarie Holzmann; Steven L Allison; Franz X Heinz
In vitro-synthesized infectious RNA as an attenuated live vaccine in a flavivirus model.
Nature medicine 1998;4(12):1438-40.
1998: Christian W Mandl; Stephan W Aberle; JH Henkel; Elisabeth Puchhammer-Stöckl; Franz X Heinz
Possible influence of the mutant CCR5 Allele on vertical transmission of HIV-1.
Journal of medical virology 1998;55(1):51-5.
1998: Christian W Mandl; Heidemarie Holzmann; T Meixner; S Rauscher; Peter F Stadler; Steven L Allison; Franz X Heinz
Spontaneous and engineered deletions in the 3' noncoding region of tick-borne encephalitis virus: construction of highly attenuated mutants of a flavivirus.
Journal of virology 1998;72(3):2132-40.
1997: S Rauscher; Christoph Flamm; Christian W Mandl; Franz X Heinz; Peter F Stadler
Secondary structure of the 3'-noncoding region of flavivirus genomes: comparative analysis of base pairing probabilities.
RNA (New York, N.Y.) 1997;3(7):779-91.
1997: Christian W Mandl; Michael Ecker; Heidemarie Holzmann; Christian Kunz; Franz X Heinz
Infectious cDNA clones of tick-borne encephalitis virus European subtype prototypic strain Neudoerfl and high virulence strain Hypr.
The Journal of general virology 1997;78 ( Pt 5)():1049-57.
1996: Stephan W Aberle; Christian W Mandl; Christian Kunz; Theresia Popow-Kraupp
Presence of human herpesvirus 6 variants A and B in saliva and peripheral blood mononuclear cells of healthy adults.
Journal of clinical microbiology 1996;34(12):3223-5.
1996: J Schalich; Steven L Allison; Karin Stiasny; Christian W Mandl; Christian Kunz; Franz X Heinz
Recombinant subviral particles from tick-borne encephalitis virus are fusogenic and provide a model system for studying flavivirus envelope glycoprotein functions.
Journal of virology 1996;70(7):4549-57.
1996: G Wallner; Christian W Mandl; Michael Ecker; Heidemarie Holzmann; Karin Stiasny; Christian Kunz; Franz X Heinz
Characterization and complete genome sequences of high- and low- virulence variants of tick-borne encephalitis virus.
The Journal of general virology 1996;77 ( Pt 5)():1035-42.
1995: Elisabeth Puchhammer-Stöckl; Christian Kunz; Christian W Mandl; Franz X Heinz
Identification of tick-borne encephalitis virus ribonucleic acid in tick suspensions and in clinical specimens by a reverse transcription-nested polymerase chain reaction assay.
Clinical and diagnostic virology 1995;4(4):321-6.
1995: Franz X Heinz; Steven L Allison; Karin Stiasny; J Schalich; Heidemarie Holzmann; Christian W Mandl; Christian Kunz
Recombinant and virion-derived soluble and particulate immunogens for vaccination against tick-borne encephalitis.
Vaccine 1995;13(17):1636-42.
1995: G Wallner; Christian W Mandl; Christian Kunz; Franz X Heinz
The flavivirus 3'-noncoding region: extensive size heterogeneity independent of evolutionary relationships among strains of tick-borne encephalitis virus.
Virology 1995;213(1):169-78.
1995: Steven L Allison; Konrad Stadler; Christian W Mandl; Christian Kunz; Franz X Heinz
Synthesis and secretion of recombinant tick-borne encephalitis virus protein E in soluble and particulate form.
Journal of virology 1995;69(9):5816-20.
1995: Steven L Allison; J Schalich; Karin Stiasny; Christian W Mandl; Christian Kunz; Franz X Heinz
Oligomeric rearrangement of tick-borne encephalitis virus envelope proteins induced by an acidic pH.
Journal of virology 1995;69(2):695-700.
1995: Christian W Mandl
[Genome sequence and antigen structure of the Powassan virus: analysis of genetic elements of tick-transmitted flaviviruses].
Wiener klinische Wochenschrift 1995;107(3):101-2.
1994: Steven L Allison; Christian W Mandl; Christian Kunz; Franz X Heinz
Expression of cloned envelope protein genes from the flavivirus tick-borne encephalitis virus in mammalian cells and random mutagenesis by PCR.
Virus genes 1994;8(3):187-98.
1994: Franz X Heinz; Karin Stiasny; G Püschner-Auer; Heidemarie Holzmann; Steven L Allison; Christian W Mandl; Christian Kunz
Structural changes and functional control of the tick-borne encephalitis virus glycoprotein E by the heterodimeric association with protein prM.
Virology 1994;198(1):109-17.
1994: Franz X Heinz; G Auer; Karin Stiasny; Heidemarie Holzmann; Christian W Mandl; Farshad Guirakhoo; Christian Kunz
The interactions of the flavivirus envelope proteins: implications for virus entry and release.
Archives of virology. Supplementum 1994;9():339-48.
1993: Franz X Heinz; Christian W Mandl
The molecular biology of tick-borne encephalitis virus. Review article.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1993;101(10):735-45.
1993: Heidemarie Holzmann; G Utter; E Norrby; Christian W Mandl; Christian Kunz; Franz X Heinz
Assessment of the antigenic structure of tick-borne encephalitis virus by the use of synthetic peptides.
The Journal of general virology 1993;74 ( Pt 9)():2031-5.
1993: Christian W Mandl; H Holzmann; Christian Kunz; Franz X Heinz
Complete genomic sequence of Powassan virus: evaluation of genetic elements in tick-borne versus mosquito-borne flaviviruses.
Virology 1993;194(1):173-84.
1991: Christian W Mandl; L Iacono-Connors; G Wallner; Heidemarie Holzmann; Christian Kunz; Franz X Heinz
Sequence of the genes encoding the structural proteins of the low-virulence tick-borne flaviviruses Langat TP21 and Yelantsev.
Virology 1991;185(2):891-5.
1991: Franz X Heinz; Christian W Mandl; Heidemarie Holzmann; Christian Kunz; B A Harris; F Rey; S C Harrison
The flavivirus envelope protein E: isolation of a soluble form from tick-borne encephalitis virus and its crystallization.
Journal of virology 1991;65(10):5579-83.
1991: Christian W Mandl; Christian Kunz; Franz X Heinz
Presence of poly(A) in a flavivirus: significant differences between the 3' noncoding regions of the genomic RNAs of tick-borne encephalitis virus strains.
Journal of virology 1991;65(8):4070-7.
1991: Elisabeth Puchhammer-Stöckl; Theresia Popow-Kraupp; Franz X Heinz; Christian W Mandl; Christian Kunz
Detection of varicella-zoster virus DNA by polymerase chain reaction in the cerebrospinal fluid of patients suffering from neurological complications associated with chicken pox or herpes zoster.
Journal of clinical microbiology 1991;29(7):1513-6.
1991: Farshad Guirakhoo; Franz X Heinz; Christian W Mandl; Heidemarie Holzmann; Christian Kunz
Fusion activity of flaviviruses: comparison of mature and immature (prM-containing) tick-borne encephalitis virions.
The Journal of general virology 1991;72 ( Pt 6)():1323-9.
1991: Christian W Mandl; Franz X Heinz; Elisabeth Puchhammer-Stöckl; Christian Kunz
Sequencing the termini of capped viral RNA by 5'-3' ligation and PCR.
BioTechniques 1991;10(4):484, 486.
1991: Farshad Guirakhoo; Franz X Heinz; Christian W Mandl; Heidemarie Holzmann; Christian Kunz; M Gresíková
The relationship between the flaviviruses Skalica and Langat as revealed by monoclonal antibodies, peptide mapping and RNA sequence analysis.
The Journal of general virology 1991;72 ( Pt 2)():333-8.
1990: Heidemarie Holzmann; Franz X Heinz; Christian W Mandl; Farshad Guirakhoo; Christian Kunz
A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model.
Journal of virology 1990;64(10):5156-9.
1990: Elisabeth Puchhammer-Stöckl; Theresia Popow-Kraupp; Franz X Heinz; Christian W Mandl; Christian Kunz
Establishment of PCR for the early diagnosis of herpes simplex encephalitis.
Journal of medical virology 1990;32(2):77-82.
1989: Christian W Mandl; Franz X Heinz; E Stöckl; Christian Kunz
Genome sequence of tick-borne encephalitis virus (Western subtype) and comparative analysis of nonstructural proteins with other flaviviruses.
Virology 1989;173(1):291-301.
1989: Christian W Mandl; Farshad Guirakhoo; Heidemarie Holzmann; Franz X Heinz; Christian Kunz
Antigenic structure of the flavivirus envelope protein E at the molecular level, using tick-borne encephalitis virus as a model.
Journal of virology 1989;63(2):564-71.
1989: Heidemarie Holzmann; Christian W Mandl; Farshad Guirakhoo; Franz X Heinz; Christian Kunz
Characterization of antigenic variants of tick-borne encephalitis virus selected with neutralizing monoclonal antibodies.
The Journal of general virology 1989;70 ( Pt 1)():219-22.
1988: Christian W Mandl; Franz X Heinz; Christian Kunz
Sequence of the structural proteins of tick-borne encephalitis virus (western subtype) and comparative analysis with other flaviviruses.
Virology 1988;166(1):197-205.