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Sandhya Mandlekar

Research Profile

Chemicals & Drugs

Living Beings

Mouse

Physiology

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Publications

TOP 3
T Thanga Mariappan; Sandhya Mandlekar; Punit Marathe
Insight into tissue unbound concentration: utility in drug discovery and development.
Cullen L Cavallaro; Jing Chen; Mary Ellen Cvijic; Paul Davies; John Hynes; Rui-Qin Liu; Sandhya Mandlekar; Anne V Rose; Andrew J Tebben; Katy Van Kirk; Andrew Watson; Hong Wu; Guchen Yang; Stephanie Briceno; Percy H Carter
Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis.
Rajareddy Kallem; Chetan P Kulkarni; S Shahe Mahammad; Dakshay Patel; Sheelendra P Singh; Michael Sinz; Megha Thakur; Sandhya Mandlekar
A simplified protocol employing elacridar in rodents: a screening model in drug discovery to assess P-gp mediated efflux at the blood brain barrier.

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All Publications

2013: T Thanga Mariappan; Sandhya Mandlekar; Punit Marathe
Insight into tissue unbound concentration: utility in drug discovery and development.
Current drug metabolism 2013;14(3):324-40.
2012: Cullen L Cavallaro; Jing Chen; Mary Ellen Cvijic; Paul Davies; John Hynes; Rui-Qin Liu; Sandhya Mandlekar; Anne V Rose; Andrew J Tebben; Katy Van Kirk; Andrew Watson; Hong Wu; Guchen Yang; Stephanie Briceno; Percy H Carter
Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis.
Journal of medicinal chemistry 2012;55(22):9643-53.
2012: Rajareddy Kallem; Chetan P Kulkarni; S Shahe Mahammad; Dakshay Patel; Sheelendra P Singh; Michael Sinz; Megha Thakur; Sandhya Mandlekar
A simplified protocol employing elacridar in rodents: a screening model in drug discovery to assess P-gp mediated efflux at the blood brain barrier.
Drug metabolism letters 2012;6(2):134-44.
2012: Percy H Carter; Robert J Cherney; Gregory D Brown; Sarah R King; Yvonne C Lo; Sandhya Mandlekar; Persymphonie B Miller; Peggy A Scherle; Andrew J Tebben; Matthew E Voss; Gengjie Yang; Qihong Zhao; Carl P Decicco
Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone.
Bioorganic & medicinal chemistry letters 2012;22(9):3311-6.
2012: Vishwanath Kurawattimath; Krishna Pocha; Ravi Kumar Trivedi; T Thanga Mariappan; Sandhya Mandlekar
A modified serial blood sampling technique and utility of dried-blood spot technique in estimation of blood concentration: application in mouse pharmacokinetics.
European journal of drug metabolism and pharmacokinetics 2012;37(1):23-30.
2010: Robert J Cherney; Ruowei Mo; Dayton T Meyer; Matthew E Voss; Michael G Yang; Joseph B Santella; John V Duncia; Yvonne C Lo; Gengjie Yang; Persymphonie B Miller; Peggy A Scherle; Qihong Zhao; Sandhya Mandlekar; Mary Ellen Cvijic; Joel C Barrish; Carl P Decicco; Percy H Carter
gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
Bioorganic & medicinal chemistry letters 2010;20(8):2425-30.
2009: Snehasis Jana; Sandhya Mandlekar
Role of phase II drug metabolizing enzymes in cancer chemoprevention.
Current drug metabolism 2009;10(6):595-616.
2008: Robert J Cherney; Ruowei Mo; Dayton T Meyer; David J Nelson; Yvonne C Lo; Gengjie Yang; Peggy A Scherle; Sandhya Mandlekar; Zelda R Wasserman; Heather Jezak; Kimberly A Solomon; Andrew J Tebben; Percy H Carter; Carl P Decicco
Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists.
Journal of medicinal chemistry 2008;51(4):721-4.
2008: Joseph B Santella; Daniel S Gardner; Wenqing Yao; Chongsheng Shi; Prabhakar Reddy; Andrew J Tebben; George V DeLucca; Dean A Wacker; Paul S Watson; Patricia K Welch; Eric A Wadman; Paul Davies; Kimberly A Solomon; Danielle Graden; Swamy Yeleswaram; Sandhya Mandlekar; Ilona Kariv; Carl P Decicco; Soo S Ko; Percy H Carter; John V Duncia
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.
Bioorganic & medicinal chemistry letters 2008;18(2):576-85.
2006: Sandhya Mandlekar; Jin-Liern Hong; Ah-Ng Tony Kong
Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects.
Current drug metabolism 2006;7(6):661-75.
2006: Anuk M Das; Kris Vaddi; Kimberly A Solomon; Candice Krauthauser; Xiaosui Jiang; Kim McIntyre; Xiao Xia Yang; Eric A Wadman; Patricia K Welch; Maryanne B Covington; Danielle Graden; Krishnaswamy Yeleswaram; James M Trzaskos; Robert C Newton; Sandhya Mandlekar; Soo S Ko; Percy H Carter; Paul Davies
Selective inhibition of eosinophil influx into the lung by small molecule CC chemokine receptor 3 antagonists in mouse models of allergic inflammation.
The Journal of pharmacology and experimental therapeutics 2006;318(1):411-7.
2003: Robert J Cherney; James J-W Duan; Matthew E Voss; Lihua Chen; Li Wang; Dayton T Meyer; Zelda R Wasserman; Karl D Hardman; Rui-Qin Liu; Maryanne B Covington; Mingxin Qian; Sandhya Mandlekar; David D Christ; James M Trzaskos; Robert C Newton; Ronald L Magolda; Ruth R Wexler; Carl P Decicco
Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.
Journal of medicinal chemistry 2003;46(10):1811-23.
2001: Sandhya Mandlekar; Ah-Ng Tony Kong
Mechanisms of tamoxifen-induced apoptosis.
Apoptosis : an international journal on programmed cell death 2001;6(6):469-77.
2001: Ah-Ng Tony Kong; R Yu; Vidya Hebbar; Chin Chen; Edward D Owuor; Rong Hu; R Ee; Sandhya Mandlekar
Signal transduction events elicited by cancer prevention compounds.
Mutation research 2001;480-481():231-41.
2001: Ah-Ng Tony Kong; Edward D Owuor; R Yu; Vidya Hebbar; Chin Chen; Rong Hu; Sandhya Mandlekar
Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).
Drug metabolism reviews 2001;33(3-4):255-71.
2001: R Yu; Vidya Hebbar; D W Kim; Sandhya Mandlekar; John M Pezzuto; Ah-Ng Tony Kong
Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways.
Molecular pharmacology 2001;60(1):217-24.
2000: Sandhya Mandlekar; Vidya Hebbar; Konstantin Christov-Tzelkov; Ah-Ng Tony Kong
Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites: activation of caspases and induction of apoptosis in rat mammary tumors and in human breast cancer cell lines.
Cancer research 2000;60(23):6601-6.
2000: Sandhya Mandlekar; R Yu; Tse-Hua Tan; Ah-Ng Tony Kong
Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells.
Cancer research 2000;60(21):5995-6000.
2000: R Yu; Sandhya Mandlekar; Ah-Ng Tony Kong
Molecular mechanisms of butylated hydroxylanisole-induced toxicity: induction of apoptosis through direct release of cytochrome c.
Molecular pharmacology 2000;58(2):431-7.
2000: R Yu; Sandhya Mandlekar; S Ruben; J Ni; Ah-Ng Tony Kong
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells.
Cancer research 2000;60(9):2384-9.
2000: R Yu; Sandhya Mandlekar; Tse-Hua Tan; Ah-Ng Tony Kong
Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C.
The Journal of biological chemistry 2000;275(13):9612-9.
2000: Ah-Ng Tony Kong; R Yu; Chin Chen; Sandhya Mandlekar; T Primiano
Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis.
Archives of pharmacal research 2000;23(1):1-16.
2000: R Yu; Sandhya Mandlekar; W Lei; W E Fahl; Tse-Hua Tan; Ah-Ng Tony Kong
p38 mitogen-activated protein kinase negatively regulates the induction of phase II drug-metabolizing enzymes that detoxify carcinogens.
The Journal of biological chemistry 2000;275(4):2322-7.
1999: R Yu; W Lei; Sandhya Mandlekar; M J Weber; Channing J Der; J Wu; Ah-Ng Tony Kong
Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.
The Journal of biological chemistry 1999;274(39):27545-52.
1999: Ah-Ng Tony Kong; Sandhya Mandlekar; R Yu; W Lei; A Fasanmande
Pharmacodynamics and toxicodynamics of drug action: signaling in cell survival and cell death.
Pharmaceutical research 1999;16(6):790-8.
1999: Alexander A Shtil; Sandhya Mandlekar; R Yu; robert walter; K Hagen; Tse-Hua Tan; Igor B Roninson; Ah-Ng Tony Kong
Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells.
Oncogene 1999;18(2):377-84.
1998: Ah-Ng Tony Kong; R Yu; W Lei; Sandhya Mandlekar; Tse-Hua Tan; David S Ucker
Differential activation of MAPK and ICE/Ced-3 protease in chemical-induced apoptosis. The role of oxidative stress in the regulation of mitogen-activated protein kinases (MAPKs) leading to gene expression and survival or activation of caspases leading to apoptosis.
Restorative neurology and neuroscience 1998;12(2-3):63-70.
1998: W Lei; R Yu; Sandhya Mandlekar; Ah-Ng Tony Kong
Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene.
Cancer research 1998;58(10):2102-6.
1998: R Yu; Sandhya Mandlekar; Kevin Harvey; David S Ucker; Ah-Ng Tony Kong
Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.
Cancer research 1998;58(3):402-8.