Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Thomas Mandrup-Poulsen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Chemicals & Drugs

Disorders

Living Beings

Physiology

Signal Transduction

Geographic Areas

Denmark

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
60
Nerup, Jørn
35
Pociot, Flemming
30
Karlsen, Allan
25
Andersen, HU
17
Billestrup, Nils
17
Størling, Joachim
14
Kristiansen, Ole
14
Johannesen, Jesper
12
Nolsøe, Runa
9
Eizirik, Decio
9
Larsen, Claus Morten
9
Donath, Marc
7
Larsen, Zenia Marian
6
Fey, Stephen
6
Andersen, NA

Sign-in to see all Coauthors

Publications

TOP 3
Bruun Christine; Heding Peter E; Rønn Sif G; Frobøse Helle; Rhodes Christopher J; Mandrup-Poulsen Thomas; Billestrup Nils
Suppressor of cytokine signalling-3 inhibits tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
Tonnesen Morten F; Grunnet Lars G; Friberg Josefine; Cardozo Alessandra K; Billestrup Nils; Eizirik Décio L; Størling Joachim; Mandrup-Poulsen Thomas
Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells.
Larsen Claus M; Faulenbach Mirjam; Vaag Allan; Ehses Jan A; Donath Marc Y; Mandrup-Poulsen Thomas
Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Thomas Mandrup-Poulsen (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Bruun Christine; Heding Peter E; Rønn Sif G; Frobøse Helle; Rhodes Christopher J; Mandrup-Poulsen Thomas; Billestrup Nils
Suppressor of cytokine signalling-3 inhibits tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
Molecular and cellular endocrinology 2009;311(1-2):32-8.
2009: Tonnesen Morten F; Grunnet Lars G; Friberg Josefine; Cardozo Alessandra K; Billestrup Nils; Eizirik Décio L; Størling Joachim; Mandrup-Poulsen Thomas
Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells.
Endocrinology 2009;150(9):4094-103.
2009: Larsen Claus M; Faulenbach Mirjam; Vaag Allan; Ehses Jan A; Donath Marc Y; Mandrup-Poulsen Thomas
Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.
Diabetes care 2009;32(9):1663-8.
2009: Grunnet Lars G; Aikin Reid; Tonnesen Morten F; Paraskevas Steven; Blaabjerg Lykke; Størling Joachim; Rosenberg Lawrence; Billestrup Nils; Maysinger Dusica; Mandrup-Poulsen Thomas
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.
Diabetes 2009;58(8):1807-15.
2009: Holst Birgitte; Egerod Kristoffer L; Jin Chunyu; Petersen Pia Steen; Østergaard Mette Viberg; Hald Jacob; Sprinkel A M Ejernaes; Størling Joachim; Mandrup-Poulsen Thomas; Holst Jens J; Thams Peter; Orskov Cathrine; Wierup Nils; Sundler Frank; Madsen Ole D; Schwartz Thue W
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction.
Endocrinology 2009;150(6):2577-85.
2009: Gylvin T; Ek J; Nolsøe R; Albrechtsen A; Andersen G; Bergholdt R; Brorsson C; Bang-Berthelsen C H; Hansen T; Karlsen A E; Billestrup N; Borch-Johnsen K; Jørgensen T; Pedersen O; Mandrup-Poulsen T; Nerup J; Pociot F
Functional SOCS1 polymorphisms are associated with variation in obesity in whites.
Diabetes, obesity & metabolism 2009;11(3):196-203.
2008: Greenbaum Carla J; Mandrup-Poulsen Thomas; McGee Paula Friedenberg; Battelino Tadej; Haastert Burkhard; Ludvigsson Johnny; Pozzilli Paolo; Lachin John M; Kolb Hubert;
Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes.
Diabetes care 2008;31(10):1966-71.
2008: Larsen Claus Morten; Mandrup-Poulsen Thomas
[Treatment of diabetes mellitus with biologic therapeutics]
Ugeskrift for laeger 2008;170(24):2134-7.
2008: Donath Marc Y; Mandrup-Poulsen Thomas
The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus.
Nature clinical practice. Endocrinology & metabolism 2008;4(5):240-1.
2008: Donath Marc Y; Størling Joachim; Berchtold Lukas A; Billestrup Nils; Mandrup-Poulsen Thomas
Cytokines and beta-cell biology: from concept to clinical translation.
Endocrine reviews 2008;29(3):334-50.
2008: Zaitseva I I; Størling J; Mandrup-Poulsen T; Berggren P-O; Zaitsev S V
The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase.
Cellular and molecular life sciences : CMLS 2008;65(7-8):1248-55.
2008: Parnaud G; Bosco D; Berney T; Pattou F; Kerr-Conte J; Donath M Y; Bruun C; Mandrup-Poulsen T; Billestrup N; Halban P A
Proliferation of sorted human and rat beta cells.
Diabetologia 2008;51(1):91-100.
2007: Larsen Claus Morten; Faulenbach Mirjam; Vaag Allan; Vølund Aage; Ehses Jan; Seifert Burkhardt; Mandrup-Poulsen Thomas; Donath Marc
[Interleukin-1 receptor antagonist-treatment of patients with type 2 diabetes]
Ugeskrift for laeger 2007;169(45):3868-71.
2007: Larsen Claus M; Faulenbach Mirjam; Vaag Allan; Vølund Aage; Ehses Jan A; Seifert Burkhardt; Mandrup-Poulsen Thomas; Donath Marc Y
Interleukin-1-receptor antagonist in type 2 diabetes mellitus.
The New England journal of medicine 2007;356(15):1517-26.
2007: Larsen L; Tonnesen M; Ronn S G; Størling J; Jørgensen S; Mascagni P; Dinarello C A; Billestrup N; Mandrup-Poulsen T
Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells.
Diabetologia 2007;50(4):779-89.
2007: Schumann Desiree M; Maedler Kathrin; Franklin Isobel; Konrad Daniel; Størling Joachim; Böni-Schnetzler Marianne; Gjinovci Asllan; Kurrer Michael O; Gauthier Benoit R; Bosco Domenico; Andres Axel; Berney Thierry; Greter Melanie; Becher Burkhard; Chervonsky Alexander V; Halban Philippe A; Mandrup-Poulsen Thomas; Wollheim Claes B; Donath Marc Y
The Fas pathway is involved in pancreatic beta cell secretory function.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2861-6.
2007: Rønn Sif G; Billestrup Nils; Mandrup-Poulsen Thomas
Diabetes and suppressors of cytokine signaling proteins.
Diabetes 2007;56(2):541-8.
2007: Mandrup-Poulsen Thomas R
[Auto-antibodies against glutamic acid decarboxylase and diabetes]
Ugeskrift for laeger 2007;169(4):300-4.
2006: Zaitseva Irina I; Sharoyko Vladimir; Størling Joachim; Efendic Suad; Guerin Christopher; Mandrup-Poulsen Thomas; Nicotera Pierluigi; Berggren Per-Olof; Zaitsev Sergei V
RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines.
Biochemical and biophysical research communications 2006;347(4):1121-8.
2006: Petersen L G; Størling J; Heding P; Li S; Berezin V; Saldeen J; Billestrup N; Bock E; Mandrup-Poulsen T
IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line.
Diabetologia 2006;49(8):1864-75.
2006: Ortis Fernanda; Cardozo Alessandra K; Crispim Daisy; Störling Joachim; Mandrup-Poulsen Thomas; Eizirik Décio L
Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.
Molecular endocrinology (Baltimore, Md.) 2006;20(8):1867-79.
2006: Frobøse Helle; Rønn Sif Groth; Heding Peter E; Mendoza Heidi; Cohen Philip; Mandrup-Poulsen Thomas; Billestrup Nils
Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex.
Molecular endocrinology (Baltimore, Md.) 2006;20(7):1587-96.
2006: Nolsøe R L; Hamid Y H; Pociot F; Paulsen S; Andersen K M; Borch-Johnsen K; Drivsholm T; Hansen T; Pedersen O; Mandrup-Poulsen T
Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance.
Genes and immunity 2006;7(4):316-21.
2006: Larsen C M; Døssing M G; Papa S; Franzoso G; Billestrup N; Mandrup-Poulsen T
Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells.
Diabetologia 2006;49(5):980-9.
2005: Kristiansen Ole P; Mandrup-Poulsen Thomas
Interleukin-6 and diabetes: the good, the bad, or the indifferent?
Diabetes 2005;54 Suppl 2():S114-24.
2005: Larsen L; Størling J; Darville M; Eizirik D L; Bonny C; Billestrup N; Mandrup-Poulsen T
Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells.
Diabetologia 2005;48(12):2582-90.
2005: Nolsøe R L; Kelly J A; Pociot F; Moser K L; Kristiansen O P; Mandrup-Poulsen T; Harley J B
Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia.
Genes and immunity 2005;6(8):699-706.
2005: Størling J; Binzer J; Andersson A K; Züllig R A; Tonnesen M; Lehmann R; Spinas G A; Sandler S; Billestrup N; Mandrup-Poulsen T
Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.
Diabetologia 2005;48(10):2039-50.
2005: Størling Joachim; Zaitsev Sergei V; Kapelioukh Iouri L; Karlsen Allan E; Billestrup Nils; Berggren Per-Olof; Mandrup-Poulsen Thomas
Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.
Endocrinology 2005;146(7):3026-36.
2005: Persson Frederik; Mogensen Carl Erik; Mandrup-Poulsen Thomas
[Is there any documentation for Lyrica in the treatment of painful diabetic neuropathy?]
Ugeskrift for laeger 2005;167(16):1768-9; author reply 1769-70.
2005: Gillespie Kathleen M; Nolsøe Runa; Betin Virginie M; Kristiansen Ole P; Bingley Polly J; Mandrup-Poulsen Thomas; Gale Edwin A M
Is puberty an accelerator of type 1 diabetes in IL6-174CC females?
Diabetes 2005;54(4):1245-8.
2005: Størling Joachim; Allaman-Pillet Nathalie; Karlsen Allan E; Billestrup Nils; Bonny Christophe; Mandrup-Poulsen Thomas
Antitumorigenic effect of proteasome inhibitors on insulinoma cells.
Endocrinology 2005;146(4):1718-26.
2005: Clausen Tine D; Mathiesen Elisabeth; Ekbom Pia; Hellmuth Ellinor; Mandrup-Poulsen Thomas; Damm Peter
Poor pregnancy outcome in women with type 2 diabetes.
Diabetes care 2005;28(2):323-8.
2005: Cardozo Alessandra K; Ortis Fernanda; Storling Joachim; Feng Ying-Mei; Rasschaert Joanne; Tonnesen Morten; Van Eylen Françoise; Mandrup-Poulsen Thomas; Herchuelz André; Eizirik Décio L
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
Diabetes 2005;54(2):452-61.
2005: Hamid Y H; Rose C S; Urhammer S A; Glümer C; Nolsøe R; Kristiansen O P; Mandrup-Poulsen T; Borch-Johnsen K; Jorgensen T; Hansen T; Pedersen O
Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes.
Diabetologia 2005;48(2):251-60.
2005: Reimers Jesper I; Larsen Claus Morten; Mandrup-Poulsen Thomas R;
[European Nicotinamide Diabetes Intervention Trial (ENDIT)--secondary publication. A randomized, placebo-controlled trial of intervention before the onset of type 1 diabetes]
Ugeskrift for laeger 2005;167(3):293-6.
2004: Karlsen A E; Heding P E; Frobøse H; Rønn S G; Kruhøffer M; Orntoft T F; Darville M; Eizirik D L; Pociot F; Nerup J; Mandrup-Poulsen T; Billestrup N
Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Diabetologia 2004;47(11):1998-2011.
2004: Gylvin T; Nolsøe R; Hansen T; Nielsen E M D; Bergholdt R; Karlsen A E; Billestrup N; Borch-Johnsen K; Pedersen O; Mandrup-Poulsen T; Nerup J; Pociot F
Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.
Diabetologia 2004;47(7):1273-7.
2004: Maedler Kathrin; Størling Joachim; Sturis Jeppe; Zuellig Richard A; Spinas Giatgen A; Arkhammar Per O G; Mandrup-Poulsen Thomas; Donath Marc Y
Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.
Diabetes 2004;53(7):1706-13.
2004: Kristiansen O P; Karlsen A E; Larsen Z M; Johannesen J; Pociot F; Mandrup-Poulsen T;
Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity.
Scandinavian journal of immunology 2004;59(6):582-91.
2004: Mandrup-Poulsen Thomas
[Transplantation between monozygotic twins]
Ugeskrift for laeger 2004;166(5):398-9; author reply 399.
2004: Bergholdt Regine; Heding Peter; Nielsen Karin; Nolsøe Runa; Sparre Thomas; Størling Joachim; Nerup Jørn; Pociot Flemming; Mandrup-Poulsen Thomas
Type 1 database mellitus: an inflammatory disease of the islet.
Advances in experimental medicine and biology 2004;552():129-53.
2003: Allaman-Pillet Nathalie; Størling Joachim; Oberson Anne; Roduit Raphael; Negri Stéphanie; Sauser Christelle; Nicod Pascal; Beckmann Jacques S; Schorderet Daniel F; Mandrup-Poulsen Thomas; Bonny Christophe
Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1.
The Journal of biological chemistry 2003;278(49):48720-6.
2003: Nolsøe Rúna L; Pociot Flemming; Novick Daniela; Rubinstein Menachem; Kim Soo-Hyun; Dinarello Charles A; Mandrup-Poulsen Thomas
Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene.
Annals of the New York Academy of Sciences 2003;1005():332-9.
2003: Mandrup-Poulsen Thomas
Beta cell death and protection.
Annals of the New York Academy of Sciences 2003;1005():32-42.
2003: Nikulina M A; Sandhu N; Shamim Z; Andersen N A; Oberson A; Dupraz P; Thorens B; Karlsen A E; Bonny C; Mandrup-Poulsen T
The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines.
Cytokine 2003;24(1-2):13-24.
2003: Mandrup-Poulsen Thomas
Apoptotic signal transduction pathways in diabetes.
Biochemical pharmacology 2003;66(8):1433-40.
2003: Møller Niels; Schmitz Ole E; Mortensen Henrik Bindesbøl; Mandrup-Poulsen Thomas; Hommel Eva E; Parving Hans-Henrik; Mogensen Carl Erik
[Insulin pumps and treatment of diabetes]
Ugeskrift for laeger 2003;165(33):3167-8; author reply 3168-9.
2003: Mandrup-Poulsen Thomas R
[Postprandial glucose fluctuations and late diabetic complications]
Ugeskrift for laeger 2003;165(33):3147.
2003: Donath Marc Y; Størling Joachim; Maedler Kathrin; Mandrup-Poulsen Thomas
Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes.
Journal of molecular medicine (Berlin, Germany) 2003;81(8):455-70.
2003: Wittrup Minna; Pildal Julie; Rasmussen Ase Krogh; Skov Birgit Guldhammer; Petersen Jørgen; Mandrup-Poulsen Thomas R
[Systemic and local allergy to human insulin]
Ugeskrift for laeger 2003;165(21):2207-8.
2003: Kristiansen Ole P; Nolsøe Runa L; Larsen Lykke; Gjesing Anette M P; Johannesen Jesper; Larsen Zenia M; Lykkesfeldt Anne E; Karlsen Allan E; Pociot Flemming; Mandrup-Poulsen Thomas;
Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females.
Human molecular genetics 2003;12(10):1101-10.
2002: Mandrup-Poulsen Thomas R
[Type 1 diabetes mellitus--an infectious disease?]
Ugeskrift for laeger 2002;164(50):5936-40.
2002: Sparre T; Christensen U Bjerre; Mose Larsen P; Fey S J; Wrzesinski K; Roepstorff P; Mandrup-Poulsen T; Pociot F; Karlsen A E; Nerup J
IL-1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis.
Diabetologia 2002;45(11):1550-61.
2002: Christie Michael R; Mølvig Jens; Hawkes Charlotte J; Carstensen Bendix; Mandrup-Poulsen Thomas;
IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin.
Diabetes care 2002;25(7):1192-7.
2002: Jensen Tonny; Musaeus Lise; Molsing Brian; Lyholm Benny; Mandrup-Poulsen Thomas
Process measures and outcome research as tools for future improvement of diabetes treatment quality.
Diabetes research and clinical practice 2002;56(3):207-11.
2002: Damm Peter; Mortensen Tine Boe; Mandrup-Poulsen Thomas R; Mathiesen Elisabeth R
[Pregnancy in women with type 2 diabetes]
Ugeskrift for laeger 2002;164(16):2145-6.
2002: Nolsøe R L; Kristiansen O P; Larsen Z M; Johannesen J; Pociot F; Mandrup-Poulsen T
Complete mutation scan of the human Fas ligand gene: linkage studies in Type I diabetes mellitus families.
Diabetologia 2002;45(1):134-9.
2002: Mandrup-Poulsen Thomas; Mølvig Jens; Pildal Julie; Rasmussen AK Ase Krogh; Andersen Lennart; Skov Birgit Guldhammer; Petersen Jørgen
Leukocytoclastic vasculitis induced by subcutaneous injection of human insulin in a patient with type 1 diabetes and essential thrombocytemia.
Diabetes care 2002;25(1):242-3.
2001: Eizirik D L; Mandrup-Poulsen T
A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis.
Diabetologia 2001;44(12):2115-33.
2001: Karlsen A E; Rønn S G; Lindberg K; Johannesen J; Galsgaard E D; Pociot F; Nielsen J H; Mandrup-Poulsen T; Nerup J; Billestrup N
Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12191-6.
2001: Johannesen J; Pociot F; Karlsen A E; Mandrup-Poulsen T; Nerup J
Strain-dependent difference in inducible nitric oxide synthesis (iNOS) expression in rat pancreatic islets correlates with interferon regulating factor 1 (IRF-1) and heat shock protein 70 (HSP70) expression.
European cytokine network 2001;12(3):501-9.
2001: Sprinkel A M; Andersen N A; Mandrup-Poulsen T
Glucose potentiates interleukin-1 beta (IL-1 beta)-induced p38 mitogen-activated protein kinase activity in rat pancreatic islets of Langerhans.
European cytokine network 2001;12(2):331-9.
2001: Mandrup-Poulsen T
beta-cell apoptosis: stimuli and signaling.
Diabetes 2001;50 Suppl 1():S58-63.
2000: Bergholdt R; Larsen Z M; Andersen N A; Johannesen J; Kristiansen O P; Mandrup-Poulsen T; Nerup J; Pociot F;
Characterization of new polymorphisms in the 5' UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level.
Genes and immunity 2000;1(8):495-500.
2000: Kristiansen O P; Nolsøe R L; Holst H; Reker S; Larsen Z M; Johannesen J; Nerup J; Pociot F; Mandrup-Poulsen T;
The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes.
Immunogenetics 2000;52(1-2):107-11.
2000: Andersen N A; Larsen C M; Mandrup-Poulsen T
TNFalpha and IFNgamma potentiate IL-1beta induced mitogen activated protein kinase activity in rat pancreatic islets of Langerhans.
Diabetologia 2000;43(11):1389-96.
2000: John N E; Andersen H U; Fey S J; Larsen P M; Roepstorff P; Larsen M R; Pociot F; Karlsen A E; Nerup J; Green I C; Mandrup-Poulsen T
Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.
Diabetes 2000;49(11):1819-29.
2000: Nikulina M A; Andersen H U; Karlsen A E; Darville M I; Eizirik D L; Mandrup-Poulsen T
Glutathione depletion inhibits IL-1 beta-stimulated nitric oxide production by reducing inducible nitric oxide synthase gene expression.
Cytokine 2000;12(9):1391-4.
2000: Ammendrup A; Maillard A; Nielsen K; Aabenhus Andersen N; Serup P; Dragsbaek Madsen O; Mandrup-Poulsen T; Bonny C
The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells.
Diabetes 2000;49(9):1468-76.
2000: Nolsøe R L; Kristiansen O P; Sangthongpitag K; Larsen Z M; Johannesen J; Karlsen A E; Pociot F; Nerup J; Verge C F; Mandrup-Poulsen T
Complete molecular scanning of the human Fas gene: mutational analysis and linkage studies in families with type I diabetes mellitus. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
Diabetologia 2000;43(6):800-8.
2000: Pavlovic D; Andersen N A; Mandrup-Poulsen T; Eizirik D L
Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells.
European cytokine network 2000;11(2):267-74.
2000: Hong T P; Andersen N A; Nielsen K; Karlsen A E; Fantuzzi G; Eizirik D L; Dinarello C A; Mandrup-Poulsen T
Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.
European cytokine network 2000;11(2):193-205.
2000: Kristiansen O P; Pociot F; Bennett E P; Clausen H; Johannesen J; Nerup J; Mandrup-Poulsen T
IDDM7 links to insulin-dependent diabetes mellitus in Danish multiplex families but linkage is not explained by novel polymorphisms in the candidate gene GALNT3. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
Human mutation 2000;15(3):295-6.
2000: Karlsen A E; Pavlovic D; Nielsen K; Jensen J; Andersen H U; Pociot F; Mandrup-Poulsen T; Eizirik D L; Nerup J
Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism.
The Journal of clinical endocrinology and metabolism 2000;85(2):830-6.
2000: Kristiansen O P; Pociot F; Johannesen J; Bergholdt R; Dinarello C A; Nerup J; Mandrup-Poulsen T
Linkage disequilibrium testing of four interleukin-1 gene-cluster polymorphisms in Danish multiplex families with insulin-dependent diabetes mellitus.
Cytokine 2000;12(2):171-5.
2000: Christensen U B; Larsen P M; Fey S J; Andersen H U; Nawrocki A; Sparre T; Mandrup-Poulsen T; Nerup J
Islet protein expression changes during diabetes development in islet syngrafts in BB-DP rats and during rejection of BB-DP islet allografts.
Autoimmunity 2000;32(1):1-15.
1999: Nielsen K; Karlsen A E; Deckert M; Madsen O D; Serup P; Mandrup-Poulsen T; Nerup J
Beta-cell maturation leads to in vitro sensitivity to cytotoxins.
Diabetes 1999;48(12):2324-32.
1999: O'Brien T; Karlsen A E; Andersen H U; Mandrup-Poulsen T; Nerup J
Absence of toxicity associated with adenoviral-mediated transfer of the beta-galactosidase reporter gene to neonatal rat islets in vitro.
Diabetes research and clinical practice 1999;44(3):157-63.
1999: Parving H H; Tarnow L; Nielsen F S; Rossing P; Mandrup-Poulsen T; Osterby R; Nerup J
Cyclosporine nephrotoxicity in type 1 diabetic patients. A 7-year follow-up study.
Diabetes care 1999;22(3):478-83.
1999: Kristiansen O P; Larsen Z M; Johannesen J; Nerup J; Mandrup-Poulsen T; Pociot F
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
Human mutation 1999;14(1):67-70.
1998: Wadt K A; Larsen C M; Andersen H U; Nielsen K; Karlsen A E; Mandrup-Poulsen T
Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase.
Diabetes 1998;47(10):1602-8.
1998: Mauricio D; Mandrup-Poulsen T
Apoptosis and the pathogenesis of IDDM: a question of life and death.
Diabetes 1998;47(10):1537-43.
1998: Mortensen H B; Mandrup-Poulsen T; Jacobsen B B; Rix M; Krabbe S; Borch-Johnsen K; Pociot F; Selskab D P
[Cow's milk-based infant formula to newborns of parents with insulin-dedent diabetes]
Ugeskrift for laeger 1998;160(27):4083-4.
1998: Larsen C M; Wadt K A; Juhl L F; Andersen H U; Karlsen A E; Su M S; Seedorf K; Shapiro L; Dinarello C A; Mandrup-Poulsen T
Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases.
The Journal of biological chemistry 1998;273(24):15294-300.
1998: Kristiansen O P; Zamani M; Johannesen J; Mandrup-Poulsen T; Cassiman J J; Nerup J; Pociot F
Linkage and association between a CD4 gene polymorphism and IDDM in Danish IDDM patients. The Danish IDDM Epidemiology and Genetics Group, and The Danish Study Group of Diabetes in Childhood.
Diabetes 1998;47(2):281-3.
1998: Christensen U B; Sparre T; Cooke A; Andersen H U; Mandrup-Poulsen T; Nerup J
Syngeneic islet transplantation in prediabetic BB-DP rats--a synchronized model for studying beta-cell destruction during the development of IDDM.
Autoimmunity 1998;28(2):91-107.
1997: Andersen H U; Fey S J; Larsen P M; Nawrocki A; Hejnaes K R; Mandrup-Poulsen T; Nerup J
Interleukin-1beta induced changes in the protein expression of rat islets: a computerized database.
Electrophoresis 1997;18(11):2091-103.
1997: Mauricio D; Andersen H U; Larsen C M; Karlsen A E; Mandrup-Poulsen T; Nerup J
Dexamethasone prevents interleukin-1beta-mediated inhibition of rat islet insulin secretion without decreasing nitric oxide production.
Cytokine 1997;9(8):563-9.
1996: Reimers J I; Rasmussen A K; Karlsen A E; Bjerre U; Liang H; Morin O; Andersen H U; Mandrup-Poulsen T; Burger A G; Feldt-Rasmussen U; Nerup J
Interleukin-1 beta inhibits rat thyroid cell function in vivo and in vitro by an NO-independent mechanism and induces hypothyroidism and accelerated thyroiditis in diabetes-prone BB rats.
The Journal of endocrinology 1996;151(1):147-57.
1996: Mandrup-Poulsen T
The role of interleukin-1 in the pathogenesis of IDDM.
Diabetologia 1996;39(9):1005-29.
1996: Reimers J I; Andersen H U; Mauricio D; Pociot F; Karlsen A E; Petersen J S; Mandrup-Poulsen T; Nerup J
Strain-dependent differences in sensitivity of rat beta-cells to interleukin 1 beta in vitro and in vivo: association with islet nitric oxide synthesis.
Diabetes 1996;45(6):771-8.
1996: Mauricio D; Mandrup-Poulsen T; Nerup J
Vitamin D analogues in insulin-dependent diabetes mellitus and other autoimmune diseases: a therapeutic perspective.
Diabetes/metabolism reviews 1996;12(1):57-68.
1996: Andersen H U; Mauricio D; Karlsen A E; Mandrup-Poulsen T; Nielsen J H; Nerup J
Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(2):251-9.
1996: Mandrup-Poulsen T; Nerup J; Reimers J I; Pociot F; Andersen H U; Karlsen A; Bjerre U; Bergholdt R
Cytokines and the endocrine system. II. Roles in substrate metabolism, modulation of thyroidal and pancreatic endocrine cell functions and autoimmune endocrine diseases.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(1):21-30.
1996: Christensen U B; Mauricio D; Reimers J I; Andersen H U; Kalland T; Nerup J; Mandrup-Poulsen T
Linomide increases plasma corticosterone in normal rats, but does not prevent the inhibitory action of IL-1 on beta-cells in vivo or ex vivo.
Autoimmunity 1996;23(4):257-68.
1995: Mandrup-Poulsen T; Nerup J; Reimers J I; Pociot F; Andersen H U; Karlsen A; Bjerre U; Bergholdt R
Cytokines and the endocrine system. I. The immunoendocrine network.
European journal of endocrinology / European Federation of Endocrine Societies 1995;133(6):660-71.
1995: Karlsen A E; Andersen H U; Vissing H; Larsen P M; Fey S J; Cuartero B G; Madsen O D; Petersen J S; Mortensen S B; Mandrup-Poulsen T
Cloning and expression of cytokine-inducible nitric oxide synthase cDNA from rat islets of Langerhans.
Diabetes 1995;44(7):753-8.
1995: Andersen H U; Larsen P M; Fey S J; Karlsen A E; Mandrup-Poulsen T; Nerup J
Two-dimensional gel electrophoresis of rat islet proteins. Interleukin 1 beta-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide.
Diabetes 1995;44(4):400-7.
1995: Mandrup-Poulsen T; Wogensen L D; Jensen M; Svensson P; Nilsson P; Emdal T; Mølvig J; Dinarello C A; Nerup J
Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury.
Critical care medicine 1995;23(1):26-33.
1994: Petersen J S; Dyrberg T; Karlsen A E; Mølvig J; Michelsen B; Nerup J; Mandrup-Poulsen T
Glutamic acid decarboxylase (GAD65) autoantibodies in prediction of beta-cell function and remission in recent-onset IDDM after cyclosporin treatment. The Canadian-European Randomized Control Trial Group.
Diabetes 1994;43(11):1291-6.
1994: Mandrup-Poulsen T; Pociot F; Mølvig J; Shapiro L; Nilsson P; Emdal T; Røder M; Kjems L L; Dinarello C A; Nerup J
Monokine antagonism is reduced in patients with IDDM.
Diabetes 1994;43(10):1242-7.
1994: Nerup J; Mandrup-Poulsen T; Helqvist S; Andersen H U; Pociot F; Reimers J I; Cuartero B G; Karlsen A E; Bjerre U; Lorenzen T
On the pathogenesis of IDDM.
Diabetologia 1994;37 Suppl 2():S82-9.
1994: Reimers J I; Bjerre U; Mandrup-Poulsen T; Nerup J
Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases.
Cytokine 1994;6(5):512-20.
1994: Andersen H U; Jørgensen K H; Egeberg J; Mandrup-Poulsen T; Nerup J
Nicotinamide prevents interleukin-1 effects on accumulated insulin release and nitric oxide production in rat islets of Langerhans.
Diabetes 1994;43(6):770-7.
1994: Reimers J I; Mørch L; Markholst H; Wogensen L D; Andersen H U; Mandrup-Poulsen T; Nerup J
Interleukin-1 beta (IL-1) does not reduce the diabetes incidence in diabetes-prone BB rats.
Autoimmunity 1994;17(2):105-18.
1993: Mandrup-Poulsen T; Reimers J I; Andersen H U; Pociot F; Karlsen A E; Bjerre U; Nerup J
Nicotinamide treatment in the prevention of insulin-dependent diabetes mellitus.
Diabetes/metabolism reviews 1993;9(4):295-309.
1993: Zumsteg U; Reimers J I; Pociot F; Mørch L; Helqvist S; Brendel M; Alejandro R; Mandrup-Poulsen T; Dinarello C A; Nerup J
Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats.
Diabetologia 1993;36(8):759-66.
1993: Mandrup-Poulsen T; Zumsteg U; Reimers J; Pociot F; Mørch L; Helqvist S; Dinarello C A; Nerup J
Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic beta-cell destruction in insulin-dependent diabetes mellitus.
Cytokine 1993;5(3):185-91.
1992: Wogensen L D; Reimers J; Nerup J; Kolb-Bachofen V; Kröncke K D; Almdal T; Mandrup-Poulsen T
Repetitive in vivo treatment with human recombinant interleukin-1 beta modifies beta-cell function in normal rats.
Diabetologia 1992;35(4):331-9.
1991: Mølvig J; Pociot F; Worsaae H; Wogensen L D; Baek L; Christensen P; Mandrup-Poulsen T; Andersen K; Madsen P; Dyerberg J
Dietary supplementation with omega-3-polyunsaturated fatty acids decreases mononuclear cell proliferation and interleukin-1 beta content but not monokine secretion in healthy and insulin-dependent diabetic individuals.
Scandinavian journal of immunology 1991;34(4):399-410.
1991: Wogensen L; Reimers J; Mandrup-Poulsen T; Nerup J
Repeated intraperitoneal injections of interleukin 1 beta induce glucose intolerance in normal rats.
Acta endocrinologica 1991;124(4):470-8.
1991: Helqvist S; Zumsteg U W; Spinas G A; Palmer J P; Mandrup-Poulsen T; Egeberg J; Nerup J
Repetitive exposure of pancreatic islets to interleukin-1 beta. An in vitro model of pre-diabetes?
Autoimmunity 1991;10(4):311-8.
1990: Mølvig J; Pociot F; Baek L; Worsaae H; Dall Wogensen L; Christensen P; Staub-Nielsen L; Mandrup-Poulsen T; Manogue K; Nerup J
Monocyte function in IDDM patients and healthy individuals.
Scandinavian journal of immunology 1990;32(3):297-311.
1990: Mandrup-Poulsen T; Mølvig J; Andersen H U; Helqvist S; Spinas G A; Munck M
Lack of predictive value of islet cell antibodies, insulin antibodies, and HLA-DR phenotype for remission in cyclosporin-treated IDDM patients. The Canadian-European Randomized Control Trial Group.
Diabetes 1990;39(2):204-10.
1990: Wogensen L D; Kolb-Bachofen V; Christensen P; Dinarello C A; Mandrup-Poulsen T; Martin S; Nerup J
Functional and morphological effects of interleukin-1 beta on the perfused rat pancreas.
Diabetologia 1990;33(1):15-23.
1990: Wogensen L; Helqvist S; Pociot F; Johannesen J; Reimers J; Mandrup-Poulsen T; Nerup J
Intra-peritoneal administration of interleukin-1 beta induces impaired insulin release from the perfused rat pancreas.
Autoimmunity 1990;7(1):1-12.
1990: Mandrup-Poulsen T; Helqvist S; Wogensen L D; Mølvig J; Pociot F; Johannesen J; Nerup J
Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells.
Current topics in microbiology and immunology 1990;164():169-93.
1989: Palmer J P; Helqvist S; Spinas G A; Mølvig J; Mandrup-Poulsen T; Andersen H U; Nerup J
Interaction of beta-cell activity and IL-1 concentration and exposure time in isolated rat islets of Langerhans.
Diabetes 1989;38(10):1211-6.
1989: Andersen H U; Mandrup-Poulsen T; Egeberg J; Helqvist S; Nerup J
Genetically determined differences in newborn rat islet sensitivity to interleukin-1 in vitro: no association with the diabetes prone phenotype in the BB-rat.
Acta endocrinologica 1989;120(1):92-8.
1989: Mandrup-Poulsen T; Helqvist S; Mølvig J; Wogensen L D; Nerup J
Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus.
Autoimmunity 1989;4(3):191-218; discussion 219-34.
1988: Nerup J; Mandrup-Poulsen T; Mølvig J; Helqvist S; Wogensen L; Egeberg J
Mechanisms of pancreatic beta-cell destruction in type I diabetes.
Diabetes care 1988;11 Suppl 1():16-23.
1988: Spinas G A; Palmer J P; Mandrup-Poulsen T; Andersen H; Nielsen J H; Nerup J
The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration.
Acta endocrinologica 1988;119(2):307-11.
1988: Wogensen L D; Mandrup-Poulsen T; Markholst H; Mølvig J; Lernmark A; Holst J J; Dinarello C A; Nerup J
Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas.
Acta endocrinologica 1988;117(3):302-6.
1988: Hansen B S; Nielsen J H; Linde S; Spinas G A; Welinder B S; Mandrup-Poulsen T; Nerup J
Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets.
Biomedica biochimica acta 1988;47(4-5):305-9.
1987: Spinas G A; Hansen B S; Linde S; Kastern W; Mølvig J; Mandrup-Poulsen T; Dinarello C A; Nielsen J H; Nerup J
Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans.
Diabetologia 1987;30(7):474-80.
1987: Mandrup-Poulsen T; Spinas G A; Prowse S J; Hansen B S; Jørgensen D W; Bendtzen K; Nielsen J H; Nerup J
Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics.
Diabetes 1987;36(5):641-7.
1987: Mandrup-Poulsen T; Egeberg J; Nerup J; Bendtzen K; Nielsen J H; Dinarello C A
Ultrastructural studies of time-course and cellular specificity of interleukin-1 mediated islet cytotoxicity.
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology 1987;95(2):55-63.
1986: Spinas G A; Mandrup-Poulsen T; Mølvig J; Baek L; Bendtzen K; Dinarello C A; Nerup J
Low concentrations of interleukin-1 stimulate and high concentrations inhibit insulin release from isolated rat islets of Langerhans.
Acta endocrinologica 1986;113(4):551-8.
1986: Mandrup-Poulsen T; Bendtzen K; Nerup J; Egeberg J; Nielsen J H
Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans.
Allergy 1986;41(4):250-9.

Sign-in to see more