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Thomas Mandrup-Poulsen

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Minh Nguyet Pham; Paolo Pozzilli; Michael Roden; Nanette C Schloot; Tadej Battelino; Hubert Kolb; Johnny Ludvigsson; Thomas Mandrup-Poulsen
Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin.
Guy W Novotny; Emil M H Pallesen; Marie B Backe; Dan P Christensen; Mattias S Dahllöf; Jakob B Hansen; Morten Lundh; Thomas Mandrup-Poulsen
Transcriptional and translational regulation of cytokine signaling in inflammatory β-cell dysfunction and apoptosis.
Mattias S Dahllöf; Charles A Dinarello; Lars G Grunnet; Morten Lundh; Dan P Christensen; Paolo Mascagni; Thomas Mandrup-Poulsen
The lysine deacetylase inhibitor Givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing.

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2013: Minh Nguyet Pham; Paolo Pozzilli; Michael Roden; Nanette C Schloot; Tadej Battelino; Hubert Kolb; Johnny Ludvigsson; Thomas Mandrup-Poulsen
Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin.
Diabetes/metabolism research and reviews 2013;29(2):166-70.
2012: Guy W Novotny; Emil M H Pallesen; Marie B Backe; Dan P Christensen; Mattias S Dahllöf; Jakob B Hansen; Morten Lundh; Thomas Mandrup-Poulsen
Transcriptional and translational regulation of cytokine signaling in inflammatory β-cell dysfunction and apoptosis.
Archives of biochemistry and biophysics 2012;528(2):171-84.
2012: Mattias S Dahllöf; Charles A Dinarello; Lars G Grunnet; Morten Lundh; Dan P Christensen; Paolo Mascagni; Thomas Mandrup-Poulsen
The lysine deacetylase inhibitor Givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing.
Islets 2012;4(6):417-22.
2012: Kasper Engholm-Keller; Thomas Mandrup-Poulsen; Flemming Pociot; Joachim Størling; Pernille Birck; Martin R Larsen
TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC.
Journal of proteomics 2012;75(18):5749-61.
2012: Jakob Bondo Hansen; R Scott Heller; Birgitte Holst; Allan E Karlsen; Andreas Nygaard Madsen; Anja Østergren Nielsen; Flemming Pociot; Klaus Qvortrup; Joachim Størling; Morten Fog Tonnesen; Mogens Aalund; Nancy C Andrews; Leeat Anker-Kitai; Luc Baeyens; Nils Billestrup; Luc Bouwens; Shimon Efrat; Josefine Friberg; Lars Groth Grunnet; Peter H Hagedorn; Thomas Mandrup-Poulsen
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.
Cell metabolism 2012;16(4):449-61.
2012: M Lundh; J Berthelsen; D P Christensen; M S Dahllöf; M Damgaard Nielsen; C A Dinarello; L G Grunnet; P Mascagni; N G Morgan; S J Richardson; T Skovgaard; A Stevenazzi; Thomas Mandrup-Poulsen
Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children.
Diabetologia 2012;55(9):2421-31.
2012: Claudia Cavelti-Weder; Charles A Dinarello; Andrea Babians-Brunner; Cornelia Keller; Malaika Kurz-Levin; Thomas Mandrup-Poulsen; Alan M Solinger; Marc A Stahel; Hany Zayed; Marc Y Donath
Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes.
Diabetes care 2012;35(8):1654-62.
2012: Thomas Mandrup-Poulsen
Perspective: Testing failures.
Nature 2012;485(7398):S17.
2012: Henrik E Poulsen; Elisabeth Specht; Morten Tonnesen; Henrik U Andersen; Kasper Broedbaek; Christina Ellervik; Trine Henriksen; Thomas Mandrup-Poulsen; Peter E Nielsen; Allan Weimann
RNA modifications by oxidation: a novel disease mechanism?
Free radical biology & medicine 2012;52(8):1353-61.
2011: Christina Ellervik; Merete Frandsen; Thomas Mandrup-Poulsen; Henrik Ullits Andersen; Henrik Birgens; Anne Tybjaerg-Hansen; Børge G Nordestgaard
Elevated transferrin saturation and risk of diabetes: three population-based studies.
Diabetes care 2011;34(10):2256-8.
2011: Joachim Størling; Per-Olof Berggren; Lisa Juntti-Berggren; Gunilla Olivecrona; Michala C Prause; Thomas Mandrup-Poulsen
Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway.
Endocrinology 2011;152(8):3040-8.
2011: Dan P Christensen; Mattias Dahllöf; Lars G Grunnet; Morten Lundh; Mette D Nielsen; Daniel Noesgaard; Nils Billestrup; Thomas Mandrup-Poulsen
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.
Molecular medicine (Cambridge, Mass.) 2011;17(5-6):378-90.
2011: Eli C Lewis; Lykke Blaabjerg; Charles A Dinarello; Paolo Mascagni; Sif G Ronn; Joachim Størling; Thomas Mandrup-Poulsen
The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro.
Molecular medicine (Cambridge, Mass.) 2011;17(5-6):369-77.
2011: Lars Groth Grunnet; Thomas Mandrup-Poulsen
Cytokines and type 1 diabetes: a numbers game.
Diabetes 2011;60(3):697-9.
2011: Nikolaj Kulahin; Lars Groth Grunnet; Morten Lundh; Dan Ploug Christensen; Rasmus Jorgensen; Anders Heding; Nils Billestrup; Vladimir Berezin; Elisabeth Bock; Thomas Mandrup-Poulsen
Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique.
FEBS letters 2011;585(1):58-64.
2011: Henrik Reinhard; Lise Tarnow; Anne Sofie Astrup; Nils Billestrup; Peter Karl Jacobsen; Won Yong Kim; Maria Lajer; Thomas Mandrup-Poulsen; Hans-Henrik Parving; Nadja Pedersen; Peter Rossing
Endothelial progenitor cells in long-standing asymptomatic type 1 diabetic patients with or without diabetic nephropathy.
Nephron. Clinical practice 2011;118(3):c309-14.
2010: M Lundh; D P Christensen; Daniel Noesgaard; P Mascagni; C A Dinarello; Nils Billestrup; L G Grunnet; Thomas Mandrup-Poulsen
Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines.
Diabetologia 2010;53(12):2569-78.
2010: Thomas Mandrup-Poulsen
IAPP boosts islet macrophage IL-1 in type 2 diabetes.
Nature immunology 2010;11(10):881-3.
2010: Charles A Dinarello; Marc Y Donath; Thomas Mandrup-Poulsen
Role of IL-1beta in type 2 diabetes.
Current opinion in endocrinology, diabetes, and obesity 2010;17(4):314-21.
2010: Thomas Mandrup-Poulsen; Linda Pickersgill; Marc Yves Donath
Blockade of interleukin 1 in type 1 diabetes mellitus.
Nature reviews. Endocrinology 2010;6(3):158-66.
2010: Rikard G Fred; Claus H Bang-Berthelsen; Thomas Mandrup-Poulsen; Lars G Grunnet; Nils Welsh
High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression.
PloS one 2010;5(5):e10843.
2009: Christine Bruun; Peter E Heding; Sif G Rønn; Helle Frobøse; Christopher J Rhodes; Thomas Mandrup-Poulsen; Nils Billestrup
Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
Molecular and cellular endocrinology 2009;311(1-2):32-8.
2009: Morten F Tonnesen; Lars G Grunnet; Josefine Friberg; Alessandra K Cardozo; Nils Billestrup; Décio L Eizirik; Joachim Størling; Thomas Mandrup-Poulsen
Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells.
Endocrinology 2009;150(9):4094-103.
2009: Claus M Larsen; Mirjam Faulenbach; Allan Vaag; Jan A Ehses; Marc Y Donath; Thomas Mandrup-Poulsen
Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.
Diabetes care 2009;32(9):1663-8.
2009: Lars G Grunnet; Reid Aikin; Morten F Tonnesen; Steven Paraskevas; Lykke Blaabjerg; Joachim Størling; Lawrence Rosenberg; Nils Billestrup; Dusica Maysinger; Thomas Mandrup-Poulsen
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.
Diabetes 2009;58(8):1807-15.
2009: Lukas A Berchtold; Claus M Larsen; Allan Vaag; Mirjam Faulenbach; Christopher T Workman; Mogens Kruhøffer; Marc Y Donath; Thomas Mandrup-Poulsen
IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes.
European cytokine network 2009;20(2):81-7.
2009: Birgitte Holst; Kristoffer Lihme Egerod; Chunyu Jin; Pia Steen Petersen; Mette Viberg Østergaard; Jacob Hald; A M Ejernaes Sprinkel; Joachim Størling; Thomas Mandrup-Poulsen; Jens J Holst; Peter Thams; Cathrine Orskov; Nils Wierup; Frank Sundler; Ole D Madsen; Thue W Schwartz
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction.
Endocrinology 2009;150(6):2577-85.
2009: T Gylvin; Jakob Ek; Runa Louise Nolsoe; Anders Albrechtsen; Gitte Andersen; Regine Bergholdt; C Brorsson; C H Bang-Berthelsen; Torben Hansen; Allan E Karlsen; Nils Billestrup; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Functional SOCS1 polymorphisms are associated with variation in obesity in whites.
Diabetes, obesity & metabolism 2009;11(3):196-203.
2008: Carla J Greenbaum; Thomas Mandrup-Poulsen; Paula Friedenberg McGee; Tadej Battelino; Burkhard Haastert; Johnny Ludvigsson; Paolo Pozzilli; John M Lachin; Hubert Kolb
Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes.
Diabetes care 2008;31(10):1966-71.
2008: Claus Morten Larsen; Thomas Mandrup-Poulsen
[Treatment of diabetes mellitus with biologic therapeutics].
Ugeskrift for laeger 2008;170(24):2134-7.
2008: Marc Y Donath; Thomas Mandrup-Poulsen
The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus.
Nature clinical practice. Endocrinology & metabolism 2008;4(5):240-1.
2008: Marc Y Donath; Joachim Størling; Lukas A Berchtold; Nils Billestrup; Thomas Mandrup-Poulsen
Cytokines and beta-cell biology: from concept to clinical translation.
Endocrine reviews 2008;29(3):334-50.
2008: Irina I Zaitseva; Joachim Størling; Thomas Mandrup-Poulsen; Per-Olof Berggren; Sergei V Zaitsev
The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase.
Cellular and molecular life sciences : CMLS 2008;65(7-8):1248-55.
2008: Géraldine Parnaud; Domenico Bosco; Thierry Berney; F Pattou; J Kerr-Conte; Marc Y Donath; C Bruun; Thomas Mandrup-Poulsen; Nils Billestrup; Philippe A Halban
Proliferation of sorted human and rat beta cells.
Diabetologia 2008;51(1):91-100.
2007: Claus Morten Larsen; Mirjam Faulenbach; Allan Vaag; Aage Voelund; Jan A Ehses; Burkhardt Seifert; Thomas Mandrup-Poulsen; Marc Y Donath
[Interleukin-1 receptor antagonist-treatment of patients with type 2 diabetes].
Ugeskrift for laeger 2007;169(45):3868-71.
2007: Claus Morten Larsen; Mirjam Faulenbach; Allan Vaag; Aage Voelund; Jan A Ehses; Burkhardt Seifert; Thomas Mandrup-Poulsen; Marc Y Donath
Interleukin-1-receptor antagonist in type 2 diabetes mellitus.
The New England journal of medicine 2007;356(15):1517-26.
2007: L Larsen; Morten Tonnesen; S G Ronn; Joachim Størling; S Jørgensen; P Mascagni; C A Dinarello; Nils Billestrup; Thomas Mandrup-Poulsen
Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells.
Diabetologia 2007;50(4):779-89.
2007: Desiree M Schumann; Kathrin Maedler; Isobel Franklin; Daniel Konrad; Joachim Størling; Marianne Böni-Schnetzler; Asllan Gjinovci; Michael O Kurrer; Benoit R Gauthier; Domenico Bosco; Axel Andres; Thierry Berney; Melanie Greter; Burkhard Becher; Alexander V Chervonsky; Philippe A Halban; Thomas Mandrup-Poulsen; Claes B Wollheim; Marc Y Donath
The Fas pathway is involved in pancreatic beta cell secretory function.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2861-6.
2007: Sif G Rønn; Nils Billestrup; Thomas Mandrup-Poulsen
Diabetes and suppressors of cytokine signaling proteins.
Diabetes 2007;56(2):541-8.
2007: Thomas Mandrup-Poulsen
[Auto-antibodies against glutamic acid decarboxylase and diabetes].
Ugeskrift for laeger 2007;169(4):300-4.
2006: Irina I Zaitseva; Vladimir Sharoyko; Joachim Størling; Suad Efendic; Christopher Guerin; Thomas Mandrup-Poulsen; Pierluigi Nicotera; Per-Olof Berggren; Sergei V Zaitsev
RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines.
Biochemical and biophysical research communications 2006;347(4):1121-8.
2006: L G Petersen; Joachim Størling; Peter E Heding; S Li; V Berezin; J Saldeen; Nils Billestrup; E Bock; Thomas Mandrup-Poulsen
IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line.
Diabetologia 2006;49(8):1864-75.
2006: Fernanda Ortis; Alessandra K Cardozo; Daisy Crispim; Joachim Störling; Thomas Mandrup-Poulsen; Decio L Eizirik
Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.
Molecular endocrinology (Baltimore, Md.) 2006;20(8):1867-79.
2006: Helle Frobøse; Sif G Rønn; Peter E Heding; Heidi Mendoza; Philip Cohen; Thomas Mandrup-Poulsen; Nils Billestrup
Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex.
Molecular endocrinology (Baltimore, Md.) 2006;20(7):1587-96.
2006: Runa Louise Nolsoe; Yasmin H Hamid; Flemming Pociot; S Paulsen; K M Andersen; Knut Borch-Johnsen; Thomas Drivsholm; Torben Hansen; Oluf Pedersen; Thomas Mandrup-Poulsen
Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance.
Genes and immunity 2006;7(4):316-21.
2006: Claus Morten Larsen; Morten Graugaard Døssing; S Papa; G Franzoso; Nils Billestrup; Thomas Mandrup-Poulsen
Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells.
Diabetologia 2006;49(5):980-9.
2005: Ole P Kristiansen; Thomas Mandrup-Poulsen
Interleukin-6 and diabetes: the good, the bad, or the indifferent?
Diabetes 2005;54 Suppl 2():S114-24.
2005: L Larsen; Joachim Størling; Martine I Darville; Decio L Eizirik; Christophe Bonny; Nils Billestrup; Thomas Mandrup-Poulsen
Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells.
Diabetologia 2005;48(12):2582-90.
2005: Runa Louise Nolsoe; J A Kelly; Flemming Pociot; K L Moser; Ole P Kristiansen; Thomas Mandrup-Poulsen; J B Harley
Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia.
Genes and immunity 2005;6(8):699-706.
2005: Joachim Størling; J Binzer; Annika K Andersson; R A Züllig; Morten Tonnesen; R Lehmann; Giatgen A Spinas; Stellan Sandler; Nils Billestrup; Thomas Mandrup-Poulsen
Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.
Diabetologia 2005;48(10):2039-50.
2005: Joachim Størling; Sergei V Zaitsev; Iouri L Kapelioukh; Allan E Karlsen; Nils Billestrup; Per-Olof Berggren; Thomas Mandrup-Poulsen
Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.
Endocrinology 2005;146(7):3026-36.
2005: Frederik Persson; Carl Erik Mogensen; Thomas Mandrup-Poulsen
[Is there any documentation for Lyrica in the treatment of painful diabetic neuropathy?].
Ugeskrift for laeger 2005;167(16):1768-9; author reply 1769-70.
2005: Kathleen M Gillespie; Runa Louise Nolsoe; Virginie M Betin; Ole P Kristiansen; Polly J Bingley; Thomas Mandrup-Poulsen; Edwin A M Gale
Is puberty an accelerator of type 1 diabetes in IL6-174CC females?
Diabetes 2005;54(4):1245-8.
2005: Joachim Størling; Nathalie Allaman-Pillet; Allan E Karlsen; Nils Billestrup; Christophe Bonny; Thomas Mandrup-Poulsen
Antitumorigenic effect of proteasome inhibitors on insulinoma cells.
Endocrinology 2005;146(4):1718-26.
2005: Tine D Clausen; Elisabeth R Mathiesen; Pia Ekbom; Ellinor Hellmuth; Thomas Mandrup-Poulsen; Peter Damm
Poor pregnancy outcome in women with type 2 diabetes.
Diabetes care 2005;28(2):323-8.
2005: Alessandra K Cardozo; Fernanda Ortis; Joachim Storling; Ying-Mei Feng; Joanne Rasschaert; Morten Tonnesen; Françoise Van Eylen; Thomas Mandrup-Poulsen; André Herchuelz; Decio L Eizirik
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
Diabetes 2005;54(2):452-61.
2005: Yasmin H Hamid; Christian Schack Rose; Søren A Urhammer; Charlotte Glümer; Runa Louise Nolsoe; Ole P Kristiansen; Thomas Mandrup-Poulsen; Knut Borch-Johnsen; T Jorgensen; Torben Hansen; Oluf Pedersen
Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes.
Diabetologia 2005;48(2):251-60.
2005: Jesper I Reimers; Claus Morten Larsen; Thomas Mandrup-Poulsen
[European Nicotinamide Diabetes Intervention Trial (ENDIT)--secondary publication. A randomized, placebo-controlled trial of intervention before the onset of type 1 diabetes].
Ugeskrift for laeger 2005;167(3):293-6.
2004: Allan E Karlsen; Peter E Heding; H Frobøse; Sif G Rønn; Mogens Kruhøffer; T F Orntoft; Martine I Darville; Decio L Eizirik; Flemming Pociot; Jørn Nerup; Thomas Mandrup-Poulsen; Nils Billestrup
Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Diabetologia 2004;47(11):1998-2011.
2004: T Gylvin; Runa Louise Nolsoe; Torben Hansen; E M D Nielsen; Regine Bergholdt; Allan E Karlsen; Nils Billestrup; Knut Borch-Johnsen; Oluf Pedersen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.
Diabetologia 2004;47(7):1273-7.
2004: Kathrin Maedler; Joachim Størling; Jeppe Sturis; Richard A Zuellig; Giatgen A Spinas; Per O G Arkhammar; Thomas Mandrup-Poulsen; Marc Y Donath
Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.
Diabetes 2004;53(7):1706-13.
2004: Ole P Kristiansen; Allan E Karlsen; Zenia Marian Larsen; Jesper Johannesen; Flemming Pociot; Thomas Mandrup-Poulsen
Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity.
Scandinavian journal of immunology 2004;59(6):582-91.
2004: Thomas Mandrup-Poulsen
[Transplantation between monozygotic twins].
Ugeskrift for laeger 2004;166(5):398-9; author reply 399.
2004: Regine Bergholdt; Peter E Heding; Karin Nielsen; Runa Louise Nolsoe; Thomas Sparre; Joachim Størling; Jørn Nerup; Flemming Pociot; Thomas Mandrup-Poulsen
Type 1 database mellitus: an inflammatory disease of the islet.
Advances in experimental medicine and biology 2004;552():129-53.
2003: Nathalie Allaman-Pillet; Joachim Størling; Anne Oberson; Raphael Roduit; Stéphanie Negri; Christelle Sauser; Pascal Nicod; Jacques Beckmann; Daniel F Schorderet; Thomas Mandrup-Poulsen; Christophe Bonny
Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1.
The Journal of biological chemistry 2003;278(49):48720-6.
2003: Runa Louise Nolsoe; Flemming Pociot; Daniela Novick; Menachem Rubinstein; Soo-Hyun Kim; Charles A Dinarello; Thomas Mandrup-Poulsen
Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene.
Annals of the New York Academy of Sciences 2003;1005():332-9.
2003: Thomas Mandrup-Poulsen
Beta cell death and protection.
Annals of the New York Academy of Sciences 2003;1005():32-42.
2003: Thomas Mandrup-Poulsen
Apoptotic signal transduction pathways in diabetes.
Biochemical pharmacology 2003;66(8):1433-40.
2003: M A Nikulina; N Sandhu; Z Shamim; NA Andersen; Anne Oberson; philippe Dupraz; B Thorens; Allan E Karlsen; C Bonny; Thomas Mandrup-Poulsen
The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines.
Cytokine 2003;24(1-2):13-24.
2003: Niels Møller; Ole E Schmitz; Henrik B Mortensen; Thomas Mandrup-Poulsen; Eva E Hommel; Hans-Henrik Parving; Carl Erik Mogensen
[Insulin pumps and treatment of diabetes].
Ugeskrift for laeger 2003;165(33):3167-8; author reply 3168-9.
2003: Thomas Mandrup-Poulsen
[Postprandial glucose fluctuations and late diabetic complications].
Ugeskrift for laeger 2003;165(33):3147.
2003: Marc Y Donath; Joachim Størling; Kathrin Maedler; Thomas Mandrup-Poulsen
Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes.
Journal of molecular medicine (Berlin, Germany) 2003;81(8):455-70.
2003: Minna Wittrup; Julie Pildal; Ase Krogh Rasmussen; Birgit Guldhammer Skov; Jørgen Petersen; Thomas Mandrup-Poulsen
[Systemic and local allergy to human insulin].
Ugeskrift for laeger 2003;165(21):2207-8.
2003: Ole P Kristiansen; Runa Louise Nolsoe; Lykke Larsen; Anette M P Gjesing; Jesper Johannesen; Zenia Marian Larsen; Anne E Lykkesfeldt; Allan E Karlsen; Flemming Pociot; Thomas Mandrup-Poulsen
Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females.
Human molecular genetics 2003;12(10):1101-10.
2002: Thomas Mandrup-Poulsen
[Type 1 diabetes mellitus--an infectious disease?].
Ugeskrift for laeger 2002;164(50):5936-40.
2002: Thomas Sparre; Ulla Bjerre Christensen; P Mose Larsen; Stephen Fey; Krzysztof Wrzesinski; Peter Roepstorff; Thomas Mandrup-Poulsen; Flemming Pociot; Allan E Karlsen; Jørn Nerup
IL-1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis.
Diabetologia 2002;45(11):1550-61.
2002: Michael R Christie; Jens Mølvig; Charlotte J Hawkes; Bendix Carstensen; Thomas Mandrup-Poulsen
IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin.
Diabetes care 2002;25(7):1192-7.
2002: Tonny Jensen; Lise Musaeus; Brian Molsing; Benny Lyholm; Thomas Mandrup-Poulsen
Process measures and outcome research as tools for future improvement of diabetes treatment quality.
Diabetes research and clinical practice 2002;56(3):207-11.
2002: Peter Damm; Tine Boe Mortensen; Thomas Mandrup-Poulsen; Elisabeth R Mathiesen
[Pregnancy in women with type 2 diabetes].
Ugeskrift for laeger 2002;164(16):2145-6.
2002: Runa Louise Nolsoe; Ole P Kristiansen; Zenia Marian Larsen; Jesper Johannesen; Flemming Pociot; Thomas Mandrup-Poulsen
Complete mutation scan of the human Fas ligand gene: linkage studies in Type I diabetes mellitus families.
Diabetologia 2002;45(1):134-9.
2002: Thomas Mandrup-Poulsen; Jens Mølvig; Julie Pildal; Ase Krogh Rasmussen AK; Lennart Andersen; Birgit Guldhammer Skov; Jørgen Petersen
Leukocytoclastic vasculitis induced by subcutaneous injection of human insulin in a patient with type 1 diabetes and essential thrombocytemia.
Diabetes care 2002;25(1):242-3.
2001: Decio L Eizirik; Thomas Mandrup-Poulsen
A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis.
Diabetologia 2001;44(12):2115-33.
2001: Allan E Karlsen; Sif G Rønn; Karen Lindberg; Jesper Johannesen; Elisabeth D Galsgaard; Flemming Pociot; Jens H Nielsen; Thomas Mandrup-Poulsen; Jørn Nerup; Nils Billestrup
Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12191-6.
2001: Jesper Johannesen; Flemming Pociot; Allan E Karlsen; Thomas Mandrup-Poulsen; Jørn Nerup
Strain-dependent difference in inducible nitric oxide synthesis (iNOS) expression in rat pancreatic islets correlates with interferon regulating factor 1 (IRF-1) and heat shock protein 70 (HSP70) expression.
European cytokine network 2001;12(3):501-9.
2001: A M Sprinkel; NA Andersen; Thomas Mandrup-Poulsen
Glucose potentiates interleukin-1 beta (IL-1 beta)-induced p38 mitogen-activated protein kinase activity in rat pancreatic islets of Langerhans.
European cytokine network 2001;12(2):331-9.
2001: Thomas Mandrup-Poulsen
beta-cell apoptosis: stimuli and signaling.
Diabetes 2001;50 Suppl 1():S58-63.
2000: Regine Bergholdt; Zenia Marian Larsen; NA Andersen; Jesper Johannesen; Ole P Kristiansen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Characterization of new polymorphisms in the 5' UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level.
Genes and immunity 2000;1(8):495-500.
2000: Ole P Kristiansen; Runa Louise Nolsoe; H Holst; Sine Reker Hadrup; Zenia Marian Larsen; Jesper Johannesen; Jørn Nerup; Flemming Pociot; Thomas Mandrup-Poulsen
The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes.
Immunogenetics 2000;52(1-2):107-11.
2000: NA Andersen; Claus Morten Larsen; Thomas Mandrup-Poulsen
TNFalpha and IFNgamma potentiate IL-1beta induced mitogen activated protein kinase activity in rat pancreatic islets of Langerhans.
Diabetologia 2000;43(11):1389-96.
2000: NE John; HU Andersen; Stephen Fey; Peter Mose Larsen; Peter Roepstorff; Martin R Larsen; Flemming Pociot; Allan E Karlsen; Jørn Nerup; Irene C Green; Thomas Mandrup-Poulsen
Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.
Diabetes 2000;49(11):1819-29.
2000: M A Nikulina; HU Andersen; Allan E Karlsen; Martine I Darville; Decio L Eizirik; Thomas Mandrup-Poulsen
Glutathione depletion inhibits IL-1 beta-stimulated nitric oxide production by reducing inducible nitric oxide synthase gene expression.
Cytokine 2000;12(9):1391-4.
2000: A Ammendrup; A Maillard; K Nielsen; N Aabenhus Andersen; P Serup; O Dragsbaek Madsen; Thomas Mandrup-Poulsen; Christophe Bonny
The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells.
Diabetes 2000;49(9):1468-76.
2000: Runa Louise Nolsoe; Ole P Kristiansen; K Sangthongpitag; Zenia Marian Larsen; Jesper Johannesen; Allan E Karlsen; Flemming Pociot; Jørn Nerup; CF Verge; Thomas Mandrup-Poulsen
Complete molecular scanning of the human Fas gene: mutational analysis and linkage studies in families with type I diabetes mellitus. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
Diabetologia 2000;43(6):800-8.
2000: D Pavlovic; NA Andersen; Thomas Mandrup-Poulsen; Decio L Eizirik
Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells.
European cytokine network 2000;11(2):267-74.
2000: T P Hong; NA Andersen; K Nielsen; Allan E Karlsen; Giamila Fantuzzi; Decio L Eizirik; Charles A Dinarello; Thomas Mandrup-Poulsen
Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.
European cytokine network 2000;11(2):193-205.
2000: Ole P Kristiansen; Flemming Pociot; E P Bennett; H Clausen; Jesper Johannesen; Jørn Nerup; Thomas Mandrup-Poulsen
IDDM7 links to insulin-dependent diabetes mellitus in Danish multiplex families but linkage is not explained by novel polymorphisms in the candidate gene GALNT3. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
Human mutation 2000;15(3):295-6.
2000: Allan E Karlsen; D Pavlovic; K Nielsen; J Jensen; HU Andersen; Flemming Pociot; Thomas Mandrup-Poulsen; Decio L Eizirik; Jørn Nerup
Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism.
The Journal of clinical endocrinology and metabolism 2000;85(2):830-6.
2000: Ole P Kristiansen; Flemming Pociot; Jesper Johannesen; Regine Bergholdt; C A Dinarello; Jørn Nerup; Thomas Mandrup-Poulsen
Linkage disequilibrium testing of four interleukin-1 gene-cluster polymorphisms in Danish multiplex families with insulin-dependent diabetes mellitus.
Cytokine 2000;12(2):171-5.
2000: Ulla Bjerre Christensen; Peter Mose Larsen; Stephen Fey; HU Andersen; Artur Nawrocki; Thomas Sparre; Thomas Mandrup-Poulsen; Jørn Nerup
Islet protein expression changes during diabetes development in islet syngrafts in BB-DP rats and during rejection of BB-DP islet allografts.
Autoimmunity 2000;32(1):1-15.
1999: K Nielsen; Allan E Karlsen; M Deckert; O D Madsen; Palle Serup; Thomas Mandrup-Poulsen; Jørn Nerup
Beta-cell maturation leads to in vitro sensitivity to cytotoxins.
Diabetes 1999;48(12):2324-32.
1999: T O'Brien; Allan E Karlsen; HU Andersen; Thomas Mandrup-Poulsen; Jørn Nerup
Absence of toxicity associated with adenoviral-mediated transfer of the beta-galactosidase reporter gene to neonatal rat islets in vitro.
Diabetes research and clinical practice 1999;44(3):157-63.
1999: Hans-Henrik Parving; Lise Tarnow; Flemming S Nielsen; Peter Rossing; Thomas Mandrup-Poulsen; R Osterby; Jørn Nerup
Cyclosporine nephrotoxicity in type 1 diabetic patients. A 7-year follow-up study.
Diabetes care 1999;22(3):478-83.
1999: Ole P Kristiansen; Zenia Marian Larsen; Jesper Johannesen; Jørn Nerup; Thomas Mandrup-Poulsen; Flemming Pociot
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
Human mutation 1999;14(1):67-70.
1998: K A Wadt; Claus Morten Larsen; HU Andersen; K Nielsen; Allan E Karlsen; Thomas Mandrup-Poulsen
Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase.
Diabetes 1998;47(10):1602-8.
1998: D Mauricio; Thomas Mandrup-Poulsen
Apoptosis and the pathogenesis of IDDM: a question of life and death.
Diabetes 1998;47(10):1537-43.
1998: Henrik B Mortensen; Thomas Mandrup-Poulsen; Bendt Brock Jacobsen; Mariane Rix; S Krabbe; K Borch-Johnsen; Flemming Pociot; D P Selskab
[Cow's milk-based infant formula to newborns of parents with insulin-dedent diabetes].
Ugeskrift for laeger 1998;160(27):4083-4.
1998: Claus Morten Larsen; K A Wadt; L F Juhl; HU Andersen; A E Karlsen; M S Su; K Seedorf; L Shapiro; C A Dinarello; Thomas Mandrup-Poulsen
Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases.
The Journal of biological chemistry 1998;273(24):15294-300.
1998: Ole P Kristiansen; M Zamani; Jesper Johannesen; Thomas Mandrup-Poulsen; J J Cassiman; Jørn Nerup; Flemming Pociot
Linkage and association between a CD4 gene polymorphism and IDDM in Danish IDDM patients. The Danish IDDM Epidemiology and Genetics Group, and The Danish Study Group of Diabetes in Childhood.
Diabetes 1998;47(2):281-3.
1998: Ulla Bjerre Christensen; Thomas Sparre; A Cooke; HU Andersen; Thomas Mandrup-Poulsen; Jørn Nerup
Syngeneic islet transplantation in prediabetic BB-DP rats--a synchronized model for studying beta-cell destruction during the development of IDDM.
Autoimmunity 1998;28(2):91-107.
1997: HU Andersen; Stephen Fey; Peter Mose Larsen; Artur Nawrocki; K R Hejnaes; Thomas Mandrup-Poulsen; Jørn Nerup
Interleukin-1beta induced changes in the protein expression of rat islets: a computerized database.
Electrophoresis 1997;18(11):2091-103.
1997: D Mauricio; HU Andersen; Claus Morten Larsen; Allan E Karlsen; Thomas Mandrup-Poulsen; Jørn Nerup
Dexamethasone prevents interleukin-1beta-mediated inhibition of rat islet insulin secretion without decreasing nitric oxide production.
Cytokine 1997;9(8):563-9.
1996: J I Reimers; A K Rasmussen; Allan E Karlsen; U Bjerre; H Liang; O Morin; HU Andersen; Thomas Mandrup-Poulsen; A G Burger; U Feldt-Rasmussen; Jørn Nerup
Interleukin-1 beta inhibits rat thyroid cell function in vivo and in vitro by an NO-independent mechanism and induces hypothyroidism and accelerated thyroiditis in diabetes-prone BB rats.
The Journal of endocrinology 1996;151(1):147-57.
1996: Thomas Mandrup-Poulsen
The role of interleukin-1 in the pathogenesis of IDDM.
Diabetologia 1996;39(9):1005-29.
1996: J I Reimers; HU Andersen; D Mauricio; Flemming Pociot; Allan E Karlsen; J S Petersen; Thomas Mandrup-Poulsen; Jørn Nerup
Strain-dependent differences in sensitivity of rat beta-cells to interleukin 1 beta in vitro and in vivo: association with islet nitric oxide synthesis.
Diabetes 1996;45(6):771-8.
1996: D Mauricio; Thomas Mandrup-Poulsen; Jørn Nerup
Vitamin D analogues in insulin-dependent diabetes mellitus and other autoimmune diseases: a therapeutic perspective.
Diabetes/metabolism reviews 1996;12(1):57-68.
1996: HU Andersen; D Mauricio; Allan E Karlsen; Thomas Mandrup-Poulsen; J H Nielsen; Jørn Nerup
Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(2):251-9.
1996: U B Christensen; D Mauricio; J I Reimers; HU Andersen; T Kalland; Jørn Nerup; Thomas Mandrup-Poulsen
Linomide increases plasma corticosterone in normal rats, but does not prevent the inhibitory action of IL-1 on beta-cells in vivo or ex vivo.
Autoimmunity 1996;23(4):257-68.
1996: Thomas Mandrup-Poulsen; Jørn Nerup; J I Reimers; Flemming Pociot; HU Andersen; Allan E Karlsen; U Bjerre; R Bergholdt
Cytokines and the endocrine system. II. Roles in substrate metabolism, modulation of thyroidal and pancreatic endocrine cell functions and autoimmune endocrine diseases.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(1):21-30.
1995: Thomas Mandrup-Poulsen; Jørn Nerup; J I Reimers; Flemming Pociot; HU Andersen; Allan E Karlsen; U Bjerre; R Bergholdt
Cytokines and the endocrine system. I. The immunoendocrine network.
European journal of endocrinology / European Federation of Endocrine Societies 1995;133(6):660-71.
1995: Allan E Karlsen; HU Andersen; Henrik Vissing; Peter Mose Larsen; Stephen Fey; B G Cuartero; Ole D Madsen; J S Petersen; Steen Mortensen; Thomas Mandrup-Poulsen
Cloning and expression of cytokine-inducible nitric oxide synthase cDNA from rat islets of Langerhans.
Diabetes 1995;44(7):753-8.
1995: HU Andersen; Peter Mose Larsen; Stephen Fey; Allan E Karlsen; Thomas Mandrup-Poulsen; Jørn Nerup
Two-dimensional gel electrophoresis of rat islet proteins. Interleukin 1 beta-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide.
Diabetes 1995;44(4):400-7.
1995: Thomas Mandrup-Poulsen; L D Wogensen; M Jensen; P Svensson; P Nilsson; T Emdal; J Mølvig; C A Dinarello; Jørn Nerup
Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury.
Critical care medicine 1995;23(1):26-33.
1994: JS Petersen; Thomas Dyrberg; Allan E Karlsen; J Mølvig; Birgitte K Michelsen; Jørn Nerup; Thomas Mandrup-Poulsen
Glutamic acid decarboxylase (GAD65) autoantibodies in prediction of beta-cell function and remission in recent-onset IDDM after cyclosporin treatment. The Canadian-European Randomized Control Trial Group.
Diabetes 1994;43(11):1291-6.
1994: Thomas Mandrup-Poulsen; Flemming Pociot; J Mølvig; L Shapiro; P Nilsson; T Emdal; ME Røder; L L Kjems; C A Dinarello; Jørn Nerup
Monokine antagonism is reduced in patients with IDDM.
Diabetes 1994;43(10):1242-7.
1994: Jørn Nerup; Thomas Mandrup-Poulsen; S Helqvist; HU Andersen; Flemming Pociot; J I Reimers; B G Cuartero; Allan E Karlsen; U Bjerre; T Lorenzen
On the pathogenesis of IDDM.
Diabetologia 1994;37 Suppl 2():S82-9.
1994: J I Reimers; U Bjerre; Thomas Mandrup-Poulsen; Jørn Nerup
Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases.
Cytokine 1994;6(5):512-20.
1994: HU Andersen; K H Jørgensen; J Egeberg; Thomas Mandrup-Poulsen; Jørn Nerup
Nicotinamide prevents interleukin-1 effects on accumulated insulin release and nitric oxide production in rat islets of Langerhans.
Diabetes 1994;43(6):770-7.
1994: J I Reimers; L Mørch; H Markholst; L D Wogensen; HU Andersen; Thomas Mandrup-Poulsen; Jørn Nerup
Interleukin-1 beta (IL-1) does not reduce the diabetes incidence in diabetes-prone BB rats.
Autoimmunity 1994;17(2):105-18.
1993: Thomas Mandrup-Poulsen; J I Reimers; HU Andersen; Flemming Pociot; Allan E Karlsen; U Bjerre; Jørn Nerup
Nicotinamide treatment in the prevention of insulin-dependent diabetes mellitus.
Diabetes/metabolism reviews 1993;9(4):295-309.
1993: U Zumsteg; J I Reimers; Flemming Pociot; L Mørch; S Helqvist; M Brendel; Rodolfo Alejandro; Thomas Mandrup-Poulsen; C A Dinarello; Jørn Nerup
Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats.
Diabetologia 1993;36(8):759-66.
1993: Thomas Mandrup-Poulsen; U Zumsteg; J Reimers; Flemming Pociot; L Mørch; S Helqvist; C A Dinarello; Jørn Nerup
Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic beta-cell destruction in insulin-dependent diabetes mellitus.
Cytokine 1993;5(3):185-91.
1992: L D Wogensen; J Reimers; Jørn Nerup; V Kolb-Bachofen; K D Kröncke; T Almdal; Thomas Mandrup-Poulsen
Repetitive in vivo treatment with human recombinant interleukin-1 beta modifies beta-cell function in normal rats.
Diabetologia 1992;35(4):331-9.
1991: J Mølvig; Flemming Pociot; H Worsaae; L D Wogensen; L Baek; P Christensen; Thomas Mandrup-Poulsen; K Andersen; P Madsen; J Dyerberg
Dietary supplementation with omega-3-polyunsaturated fatty acids decreases mononuclear cell proliferation and interleukin-1 beta content but not monokine secretion in healthy and insulin-dependent diabetic individuals.
Scandinavian journal of immunology 1991;34(4):399-410.
1991: L Wogensen; J Reimers; Thomas Mandrup-Poulsen; Jørn Nerup
Repeated intraperitoneal injections of interleukin 1 beta induce glucose intolerance in normal rats.
Acta endocrinologica 1991;124(4):470-8.
1991: S Helqvist; U W Zumsteg; G A Spinas; J P Palmer; Thomas Mandrup-Poulsen; J Egeberg; Jørn Nerup
Repetitive exposure of pancreatic islets to interleukin-1 beta. An in vitro model of pre-diabetes?
Autoimmunity 1991;10(4):311-8.
1990: J Mølvig; Flemming Pociot; L Baek; H Worsaae; L Dall Wogensen; P Christensen; L Staub-Nielsen; Thomas Mandrup-Poulsen; K Manogue; Jørn Nerup
Monocyte function in IDDM patients and healthy individuals.
Scandinavian journal of immunology 1990;32(3):297-311.
1990: Thomas Mandrup-Poulsen; J Mølvig; HU Andersen; S Helqvist; G A Spinas; M Munck
Lack of predictive value of islet cell antibodies, insulin antibodies, and HLA-DR phenotype for remission in cyclosporin-treated IDDM patients. The Canadian-European Randomized Control Trial Group.
Diabetes 1990;39(2):204-10.
1990: L D Wogensen; V Kolb-Bachofen; P Christensen; C A Dinarello; Thomas Mandrup-Poulsen; S Martin; Jørn Nerup
Functional and morphological effects of interleukin-1 beta on the perfused rat pancreas.
Diabetologia 1990;33(1):15-23.
1990: L Wogensen; S Helqvist; Flemming Pociot; Jesper Johannesen; J Reimers; Thomas Mandrup-Poulsen; Jørn Nerup
Intra-peritoneal administration of interleukin-1 beta induces impaired insulin release from the perfused rat pancreas.
Autoimmunity 1990;7(1):1-12.
1990: Thomas Mandrup-Poulsen; S Helqvist; L D Wogensen; J Mølvig; Flemming Pociot; Jesper Johannesen; Jørn Nerup
Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells.
Current topics in microbiology and immunology 1990;164():169-93.
1989: J P Palmer; S Helqvist; G A Spinas; J Mølvig; Thomas Mandrup-Poulsen; HU Andersen; Jørn Nerup
Interaction of beta-cell activity and IL-1 concentration and exposure time in isolated rat islets of Langerhans.
Diabetes 1989;38(10):1211-6.
1989: HU Andersen; Thomas Mandrup-Poulsen; J Egeberg; S Helqvist; Jørn Nerup
Genetically determined differences in newborn rat islet sensitivity to interleukin-1 in vitro: no association with the diabetes prone phenotype in the BB-rat.
Acta endocrinologica 1989;120(1):92-8.
1989: Thomas Mandrup-Poulsen; S Helqvist; J Mølvig; L D Wogensen; Jørn Nerup
Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus.
Autoimmunity 1989;4(3):191-218; discussion 219-34.
1988: Jørn Nerup; Thomas Mandrup-Poulsen; J Mølvig; S Helqvist; L Wogensen; J Egeberg
Mechanisms of pancreatic beta-cell destruction in type I diabetes.
Diabetes care 1988;11 Suppl 1():16-23.
1988: G A Spinas; J P Palmer; Thomas Mandrup-Poulsen; H Andersen; J H Nielsen; Jørn Nerup
The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration.
Acta endocrinologica 1988;119(2):307-11.
1988: L D Wogensen; Thomas Mandrup-Poulsen; H Markholst; J Mølvig; A Lernmark; J J Holst; C A Dinarello; Jørn Nerup
Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas.
Acta endocrinologica 1988;117(3):302-6.
1988: B S Hansen; Jens H Nielsen; S Linde; G A Spinas; B S Welinder; Thomas Mandrup-Poulsen; Jørn Nerup
Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets.
Biomedica biochimica acta 1988;47(4-5):305-9.
1987: G A Spinas; B S Hansen; S Linde; W Kastern; J Mølvig; Thomas Mandrup-Poulsen; C A Dinarello; Jens H Nielsen; Jørn Nerup
Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans.
Diabetologia 1987;30(7):474-80.
1987: Thomas Mandrup-Poulsen; G A Spinas; Stephen James Prowse; B S Hansen; D W Jørgensen; K Bendtzen; J H Nielsen; Jørn Nerup
Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics.
Diabetes 1987;36(5):641-7.
1987: Thomas Mandrup-Poulsen; J Egeberg; Jørn Nerup; K Bendtzen; J H Nielsen; C A Dinarello
Ultrastructural studies of time-course and cellular specificity of interleukin-1 mediated islet cytotoxicity.
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology 1987;95(2):55-63.
1986: G A Spinas; Thomas Mandrup-Poulsen; J Mølvig; L Baek; K Bendtzen; C A Dinarello; Jørn Nerup
Low concentrations of interleukin-1 stimulate and high concentrations inhibit insulin release from isolated rat islets of Langerhans.
Acta endocrinologica 1986;113(4):551-8.
1986: Thomas Mandrup-Poulsen; K Bendtzen; Jørn Nerup; J Egeberg; J H Nielsen
Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans.
Allergy 1986;41(4):250-9.