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David Mangelsdorf
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Chemicals & Drugs
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Physiology
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Network (preview)
24
Evans, Ronald
19
Kliewer, Steven
19
Repa, Joyce
12
Cummins, Carolyn
11
Bookout, Angie
9
Umesono, Kazuhiko
8
Lobaccaro, Jean-Marc
8
Tontonoz, Peter
7
Inagaki, Takeshi
7
Moschetta, Antonio
6
Motola, Daniel
6
Ong, Estelita
6
Heyman, Richard
6
Joseph, Sean
6
Volle, David
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All Publications
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2009: Jeong Yangsik; Mangelsdorf David J
Nuclear receptor regulation of stemness and stem cell differentiation.
Experimental & molecular medicine 2009;41(8):525-37.
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2009: Potthoff Matthew J; Inagaki Takeshi; Satapati Santhosh; Ding Xunshan; He Tianteng; Goetz Regina; Mohammadi Moosa; Finck Brian N; Mangelsdorf David J; Kliewer Steven A; Burgess Shawn C
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(26):10853-8.
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2009: Wang Zhu; Zhou X Edward; Motola Daniel L; Gao Xin; Suino-Powell Kelly; Conneely Aoife; Ogata Craig; Sharma Kamalesh K; Auchus Richard J; Lok James B; Hawdon John M; Kliewer Steven A; Xu H Eric; Mangelsdorf David J
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9138-43.
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2009: McKenna Neil J; Cooney Austin J; DeMayo Francesco J; Downes Michael; Glass Christopher K; Lanz Rainer B; Lazar Mitchell A; Mangelsdorf David J; Moore David D; Qin Jun; Steffen David L; Tsai Ming-Jer; Tsai Sophia Y; Yu Ruth; Margolis Ronald N; Evans Ronald M; O'Malley Bert W
Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas.
Molecular endocrinology (Baltimore, Md.) 2009;23(6):740-6.
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2009: Sun Tingwan; Fu Mingui; Bookout Angie L; Kliewer Steven A; Mangelsdorf David J
MicroRNA let-7 regulates 3T3-L1 adipogenesis.
Molecular endocrinology (Baltimore, Md.) 2009;23(6):925-31.
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2009: Sharma Kamalesh K; Wang Zhu; Motola Daniel L; Cummins Carolyn L; Mangelsdorf David J; Auchus Richard J
Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.
Molecular endocrinology (Baltimore, Md.) 2009;23(5):640-8.
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2009: Xie Chang-Qing; Jeong Yangsik; Fu Mingui; Bookout Angie L; Garcia-Barrio Minerva T; Sun Tingwan; Kim Bong-Hyun; Xie Yang; Root Sierra; Zhang Jifeng; Xu Ren-He; Chen Y Eugene; Mangelsdorf David J
Expression profiling of nuclear receptors in human and mouse embryonic stem cells.
Molecular endocrinology (Baltimore, Md.) 2009;23(5):724-33.
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2009: Bethke Axel; Fielenbach Nicole; Wang Zhu; Mangelsdorf David J; Antebi Adam
Nuclear hormone receptor regulation of microRNAs controls developmental progression.
Science (New York, N.Y.) 2009;324(5923):95-8.
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2008: Schmidt Daniel R; Mangelsdorf David J
Nuclear receptors of the enteric tract: guarding the frontier.
Nutrition reviews 2008;66(10 Suppl 2):S88-97.
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2008: Satapati Santhosh; He Tianteng; Inagaki Takeshi; Potthoff Matthew; Merritt Matthew E; Esser Victoria; Mangelsdorf David J; Kliewer Steven A; Browning Jeffrey D; Burgess Shawn C
Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.
Diabetes 2008;57(8):2012-21.
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2008: Inagaki Takeshi; Lin Vicky Y; Goetz Regina; Mohammadi Moosa; Mangelsdorf David J; Kliewer Steven A
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.
Cell metabolism 2008;8(1):77-83.
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2008: Lee Youn-Kyoung; Schmidt Daniel R; Cummins Carolyn L; Choi Mihwa; Peng Li; Zhang Yuan; Goodwin Bryan; Hammer Robert E; Mangelsdorf David J; Kliewer Steven A
Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.
Molecular endocrinology (Baltimore, Md.) 2008;22(6):1345-56.
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2008: Wang Haibo; Zhang Yuan; Yehuda-Shnaidman Einav; Medvedev Alexander V; Kumar Naresh; Daniel Kiefer W; Robidoux Jacques; Czech Michael P; Mangelsdorf David J; Collins Sheila
Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.
Molecular and cellular biology 2008;28(7):2187-200.
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2008: DuSell Carolyn D; Umetani Michihisa; Shaul Philip W; Mangelsdorf David J; McDonnell Donald P
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.
Molecular endocrinology (Baltimore, Md.) 2008;22(1):65-77.
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2007: Jung Diana; Inagaki Takeshi; Gerard Robert D; Dawson Paul A; Kliewer Steven A; Mangelsdorf David J; Moschetta Antonio
FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.
Journal of lipid research 2007;48(12):2693-700.
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2007: Umetani Michihisa; Domoto Hideharu; Gormley Andrew K; Yuhanna Ivan S; Cummins Carolyn L; Javitt Norman B; Korach Kenneth S; Shaul Philip W; Mangelsdorf David J
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.
Nature medicine 2007;13(10):1185-92.
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2007: Inagaki Takeshi; Dutchak Paul; Zhao Guixiang; Ding Xunshan; Gautron Laurent; Parameswara Vinay; Li Yong; Goetz Regina; Mohammadi Moosa; Esser Victoria; Elmquist Joel K; Gerard Robert D; Burgess Shawn C; Hammer Robert E; Mangelsdorf David J; Kliewer Steven A
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.
Cell metabolism 2007;5(6):415-25.
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2007: Houten Sander M; Volle David H; Cummins Carolyn L; Mangelsdorf David J; Auwerx Johan
In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.
Molecular endocrinology (Baltimore, Md.) 2007;21(6):1312-23.
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2007: Gerisch Birgit; Rottiers Veerle; Li Dongling; Motola Daniel L; Cummins Carolyn L; Lehrach Hans; Mangelsdorf David J; Antebi Adam
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5014-9.
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2007: Baker Keith D; Beckstead Robert B; Mangelsdorf David J; Thummel Carl S
Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila.
Genes & development 2007;21(4):450-64.
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2007: Chen Wenling; Chen Guoxen; Head Daphne L; Mangelsdorf David J; Russell David W
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.
Cell metabolism 2007;5(1):73-9.
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2006: Germain Pierre; Chambon Pierre; Eichele Gregor; Evans Ronald M; Lazar Mitchell A; Leid Mark; De Lera Angel R; Lotan Reuben; Mangelsdorf David J; Gronemeyer Hinrich
International Union of Pharmacology. LXIII. Retinoid X receptors.
Pharmacological reviews 2006;58(4):760-72.
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2006: Moore David D; Kato Shigeaki; Xie Wen; Mangelsdorf David J; Schmidt Daniel R; Xiao Rui; Kliewer Steven A
International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.
Pharmacological reviews 2006;58(4):742-59.
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2006: Germain Pierre; Chambon Pierre; Eichele Gregor; Evans Ronald M; Lazar Mitchell A; Leid Mark; De Lera Angel R; Lotan Reuben; Mangelsdorf David J; Gronemeyer Hinrich
International Union of Pharmacology. LX. Retinoic acid receptors.
Pharmacological reviews 2006;58(4):712-25.
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2006: Cummins C L; Mangelsdorf D J
Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland.
Biochemical Society transactions 2006;34(Pt 6):1110-3.
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2006: Choi Mihwa; Moschetta Antonio; Bookout Angie L; Peng Li; Umetani Michihisa; Holmstrom Sam R; Suino-Powell Kelly; Xu H Eric; Richardson James A; Gerard Robert D; Mangelsdorf David J; Kliewer Steven A
Identification of a hormonal basis for gallbladder filling.
Nature medicine 2006;12(11):1253-5.
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2006: Yang Chendong; McDonald Jeffrey G; Patel Amit; Zhang Yuan; Umetani Michihisa; Xu Fang; Westover Emily J; Covey Douglas F; Mangelsdorf David J; Cohen Jonathan C; Hobbs Helen H
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.
The Journal of biological chemistry 2006;281(38):27816-26.
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2006: Yang Xiaoyong; Downes Michael; Yu Ruth T; Bookout Angie L; He Weimin; Straume Marty; Mangelsdorf David J; Evans Ronald M
Nuclear receptor expression links the circadian clock to metabolism.
Cell 2006;126(4):801-10.
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2006: Bookout Angie L; Jeong Yangsik; Downes Michael; Yu Ruth T; Evans Ronald M; Mangelsdorf David J
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network.
Cell 2006;126(4):789-99.
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2006: Cummins Carolyn L; Volle David H; Zhang Yuan; McDonald Jeffrey G; Sion Benoît; Lefrançois-Martinez Anne-Marie; Caira Françoise; Veyssière Georges; Mangelsdorf David J; Lobaccaro Jean-Marc A
Liver X receptors regulate adrenal cholesterol balance.
The Journal of clinical investigation 2006;116(7):1902-12.
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2006: Rottiers Veerle; Motola Daniel L; Gerisch Birgit; Cummins Carolyn L; Nishiwaki Kiyoji; Mangelsdorf David J; Antebi Adam
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.
Developmental cell 2006;10(4):473-82.
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2006: Motola Daniel L; Cummins Carolyn L; Rottiers Veerle; Sharma Kamalesh K; Li Tingting; Li Yong; Suino-Powell Kelly; Xu H Eric; Auchus Richard J; Antebi Adam; Mangelsdorf David J
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.
Cell 2006;124(6):1209-23.
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2006: Inagaki Takeshi; Moschetta Antonio; Lee Youn-Kyoung; Peng Li; Zhao Guixiang; Downes Michael; Yu Ruth T; Shelton John M; Richardson James A; Repa Joyce J; Mangelsdorf David J; Kliewer Steven A
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3920-5.
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2006: Bookout Angie L; Cummins Carolyn L; Mangelsdorf David J; Pesola Jean M; Kramer Martha F
High-throughput real-time quantitative reverse transcription PCR.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2006;Chapter 15():Unit 15.8.
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2006: Kalaany Nada Y; Mangelsdorf David J
LXRS and FXR: the yin and yang of cholesterol and fat metabolism.
Annual review of physiology 2006;68():159-91.
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2005: Inagaki Takeshi; Choi Mihwa; Moschetta Antonio; Peng Li; Cummins Carolyn L; McDonald Jeffrey G; Luo Guizhen; Jones Stacey A; Goodwin Bryan; Richardson James A; Gerard Robert D; Repa Joyce J; Mangelsdorf David J; Kliewer Steven A
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Cell metabolism 2005;2(4):217-25.
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2005: Barish Grant D; Downes Michael; Alaynick William A; Yu Ruth T; Ocampo Corinne B; Bookout Angie L; Mangelsdorf David J; Evans Ronald M
A Nuclear Receptor Atlas: macrophage activation.
Molecular endocrinology (Baltimore, Md.) 2005;19(10):2466-77.
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2005: Fu Mingui; Sun Tingwan; Bookout Angie L; Downes Michael; Yu Ruth T; Evans Ronald M; Mangelsdorf David J
A Nuclear Receptor Atlas: 3T3-L1 adipogenesis.
Molecular endocrinology (Baltimore, Md.) 2005;19(10):2437-50.
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2005: Shulman Andrew I; Mangelsdorf David J
Retinoid x receptor heterodimers in the metabolic syndrome.
The New England journal of medicine 2005;353(6):604-15.
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2005: Kalaany Nada Y; Gauthier Karine C; Zavacki Ann Marie; Mammen Pradeep P A; Kitazume Tatsuya; Peterson Julian A; Horton Jay D; Garry Daniel J; Bianco Antonio C; Mangelsdorf David J
LXRs regulate the balance between fat storage and oxidation.
Cell metabolism 2005;1(4):231-44.
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2005: Arai Satoko; Shelton John M; Chen Mingyi; Bradley Michelle N; Castrillo Antonio; Bookout Angie L; Mak Puiying A; Edwards Peter A; Mangelsdorf David J; Tontonoz Peter; Miyazaki Toru
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.
Cell metabolism 2005;1(3):201-13.
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2005: Marceau Geoffroy; Volle David H; Gallot Denis; Mangelsdorf David J; Sapin Vincent; Lobaccaro Jean-Marc A
Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2005;283(1):175-81.
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2005: Yu Liqing; Gupta Sarita; Xu Fang; Liverman Amy D B; Moschetta Antonio; Mangelsdorf David J; Repa Joyce J; Hobbs Helen H; Cohen Jonathan C
Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion.
The Journal of biological chemistry 2005;280(10):8742-7.
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2004: Moschetta Antonio; Bookout Angie L; Mangelsdorf David J
Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.
Nature medicine 2004;10(12):1352-8.
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2004: Frenoux J-M; Vernet P; Volle D H; Britan A; Saez F; Kocer A; Henry-Berger J; Mangelsdorf D J; Lobaccaro J-M A; Drevet J R
Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.
Journal of molecular endocrinology 2004;33(2):361-75.
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2004: Watanabe Mitsuhiro; Houten Sander M; Wang Li; Moschetta Antonio; Mangelsdorf David J; Heyman Richard A; Moore David D; Auwerx Johan
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.
The Journal of clinical investigation 2004;113(10):1408-18.
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2004: Cheng Jeffrey B; Levine Michael A; Bell Norman H; Mangelsdorf David J; Russell David W
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(20):7711-5.
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2004: Volle David H; Repa Joyce J; Mazur Andrzej; Cummins Carolyn L; Val Pierre; Henry-Berger Joelle; Caira Francoise; Veyssiere Georges; Mangelsdorf David J; Lobaccaro Jean-Marc A
Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.
Molecular endocrinology (Baltimore, Md.) 2004;18(4):888-98.
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2004: Zhang Yuan; Repa Joyce J; Inoue Yusuke; Hayhurst Graham P; Gonzalez Frank J; Mangelsdorf David J
Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors.
Molecular endocrinology (Baltimore, Md.) 2004;18(4):851-62.
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2004: Shulman Andrew I; Larson Christopher; Mangelsdorf David J; Ranganathan Rama
Structural determinants of allosteric ligand activation in RXR heterodimers.
Cell 2004;116(3):417-29.
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2003: Hinshelwood Margaret M; Repa Joyce J; Shelton John M; Richardson James A; Mangelsdorf David J; Mendelson Carole R
Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function.
Molecular and cellular endocrinology 2003;207(1-2):39-45.
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2003: Cheng Jeffrey B; Motola Daniel L; Mangelsdorf David J; Russell David W
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase.
The Journal of biological chemistry 2003;278(39):38084-93.
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2003: Baker Keith D; Shewchuk Lisa M; Kozlova Tatiana; Makishima Makoto; Hassell Annie; Wisely Bruce; Caravella Justin A; Lambert Millard H; Reinking Jeffrey L; Krause Henry; Thummel Carl S; Willson Timothy M; Mangelsdorf David J
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway.
Cell 2003;113(6):731-42.
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2003: Tontonoz Peter; Mangelsdorf David J
Liver X receptor signaling pathways in cardiovascular disease.
Molecular endocrinology (Baltimore, Md.) 2003;17(6):985-93.
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2003: Laffitte Bryan A; Chao Lily C; Li Jing; Walczak Robert; Hummasti Sarah; Joseph Sean B; Castrillo Antonio; Wilpitz Damien C; Mangelsdorf David J; Collins Jon L; Saez Enrique; Tontonoz Peter
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5419-24.
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2003: Castrillo Antonio; Joseph Sean B; Marathe Chaitra; Mangelsdorf David J; Tontonoz Peter
Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages.
The Journal of biological chemistry 2003;278(12):10443-9.
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2003: Joseph Sean B; Castrillo Antonio; Laffitte Bryan A; Mangelsdorf David J; Tontonoz Peter
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.
Nature medicine 2003;9(2):213-9.
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2003: Goodwin Bryan; Gauthier Karine C; Umetani Michihisa; Watson Michael A; Lochansky Matthew I; Collins Jon L; Leitersdorf Eran; Mangelsdorf David J; Kliewer Steven A; Repa Joyce J
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):223-8.
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2003: Bookout Angie L; Mangelsdorf David J
Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways.
Nuclear receptor signaling 2003;1():e012.
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2002: Repa Joyce J; Mangelsdorf David J
The liver X receptor gene team: potential new players in atherosclerosis.
Nature medicine 2002;8(11):1243-8.
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2002: Lee Y; Yu X; Gonzales F; Mangelsdorf D J; Wang May-Yun; Richardson C; Witters L A; Unger R H
PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11848-53.
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2002: Tangirala Rajendra K; Bischoff Eric D; Joseph Sean B; Wagner Brandee L; Walczak Robert; Laffitte Bryan A; Daige Chris L; Thomas Diane; Heyman Richard A; Mangelsdorf David J; Wang Xuping; Lusis Aldons J; Tontonoz Peter; Schulman Ira G
Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11896-901.
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2002: Mak Puiying A; Laffitte Bryan A; Desrumaux Catherine; Joseph Sean B; Curtiss Linda K; Mangelsdorf David J; Tontonoz Peter; Edwards Peter A
Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
The Journal of biological chemistry 2002;277(35):31900-8.
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2002: Makishima Makoto; Lu Timothy T; Xie Wen; Whitfield G Kerr; Domoto Hideharu; Evans Ronald M; Haussler Mark R; Mangelsdorf David J
Vitamin D receptor as an intestinal bile acid sensor.
Science (New York, N.Y.) 2002;296(5571):1313-6.
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2002: Urizar Nancy L; Liverman Amy B; Dodds D'Nette T; Silva Frank Valentin; Ordentlich Peter; Yan Yingzhuo; Gonzalez Frank J; Heyman Richard A; Mangelsdorf David J; Moore David D
A natural product that lowers cholesterol as an antagonist ligand for FXR.
Science (New York, N.Y.) 2002;296(5573):1703-6.
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2002: Repa Joyce J; Berge Knut E; Pomajzl Chris; Richardson James A; Hobbs Helen; Mangelsdorf David J
Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.
The Journal of biological chemistry 2002;277(21):18793-800.
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2002: Zhang Yuan; Mangelsdorf David J
LuXuRies of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing.
Molecular interventions 2002;2(2):78-87.
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2001: Doyle D F; Braasch D A; Jackson L K; Weiss H E; Boehm M F; Mangelsdorf D J; Corey D R
Engineering orthogonal ligand-receptor pairs from "near drugs".
Journal of the American Chemical Society 2001;123(46):11367-71.
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2001: Zhang Y; Repa J J; Gauthier K; Mangelsdorf D J
Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.
The Journal of biological chemistry 2001;276(46):43018-24.
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2001: Lu T T; Repa J J; Mangelsdorf D J
Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism.
The Journal of biological chemistry 2001;276(41):37735-8.
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2001: Lobaccaro J M; Repa J J; Lu T T; Caira F; Henry-Berger J; Volle D H; Mangelsdorf D J
[Regulation of lipid metabolism by the orphan nuclear receptors]
Annales d'endocrinologie 2001;62(3):239-47.
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2001: Laffitte B A; Repa J J; Joseph S B; Wilpitz D C; Kast H R; Mangelsdorf D J; Tontonoz P
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):507-12.
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2000: Schultz J R; Tu H; Luk A; Repa J J; Medina J C; Li L; Schwendner S; Wang S; Thoolen M; Mangelsdorf D J; Lustig K D; Shan B
Role of LXRs in control of lipogenesis.
Genes & development 2000;14(22):2831-8.
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2000: Repa J J; Liang G; Ou J; Bashmakov Y; Lobaccaro J M; Shimomura I; Shan B; Brown M S; Goldstein J L; Mangelsdorf D J
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
Genes & development 2000;14(22):2819-30.
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2000: Baker K D; Warren J T; Thummel C S; Gilbert L I; Mangelsdorf D J
Transcriptional activation of the Drosophila ecdysone receptor by insect and plant ecdysteroids.
Insect biochemistry and molecular biology 2000;30(11):1037-43.
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2000: Lu T T; Makishima M; Repa J J; Schoonjans K; Kerr T A; Auwerx J; Mangelsdorf D J
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.
Molecular cell 2000;6(3):507-15.
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2000: Repa J J; Turley S D; Lobaccaro J A; Medina J; Li L; Lustig K; Shan B; Heyman R A; Dietschy J M; Mangelsdorf D J
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
Science (New York, N.Y.) 2000;289(5484):1524-9.
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2000: Venkateswaran A; Repa J J; Lobaccaro J M; Bronson A; Mangelsdorf D J; Edwards P A
Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols.
The Journal of biological chemistry 2000;275(19):14700-7.
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2000: Doyle D F; Mangelsdorf D J; Corey D R
Modifying ligand specificity of gene regulatory proteins.
Current opinion in chemical biology 2000;4(1):60-3.
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1999: Makishima M; Okamoto A Y; Repa J J; Tu H; Learned R M; Luk A; Hull M V; Lustig K D; Mangelsdorf D J; Shan B
Identification of a nuclear receptor for bile acids.
Science (New York, N.Y.) 1999;284(5418):1362-5.
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1999: Janowski B A; Grogan M J; Jones S A; Wisely G B; Kliewer S A; Corey E J; Mangelsdorf D J
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):266-71.
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1998: Peet D J; Janowski B A; Mangelsdorf D J
The LXRs: a new class of oxysterol receptors.
Current opinion in genetics & development 1998;8(5):571-5.
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1998: Wang M Y; Koyama K; Shimabukuro M; Mangelsdorf D; Newgard C B; Unger R H
Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11921-6.
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1998: Peet D J; Turley S D; Ma W; Janowski B A; Lobaccaro J M; Hammer R E; Mangelsdorf D J
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha.
Cell 1998;93(5):693-704.
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1998: Peet D J; Doyle D F; Corey D R; Mangelsdorf D J
Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR.
Chemistry & biology 1998;5(1):13-21.
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1997: Harmon M A; Scott T C; Li Y; Boehm M F; Phillips M A; Mangelsdorf D J
Trypanosoma brucei: effects of methoprene and other isoprenoid compounds on procyclic and bloodstream forms in vitro and in mice.
Experimental parasitology 1997;87(3):229-36.
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1997: Willy P J; Mangelsdorf D J
Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.
Genes & development 1997;11(3):289-98.
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1996: Janowski B A; Willy P J; Devi T R; Falck J R; Mangelsdorf D J
An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha.
Nature 1996;383(6602):728-31.
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1995: Mangelsdorf D J; Evans R M
The RXR heterodimers and orphan receptors.
Cell 1995;83(6):841-50.
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1995: Mangelsdorf D J; Thummel C; Beato M; Herrlich P; Schütz G; Umesono K; Blumberg B; Kastner P; Mark M; Chambon P; Evans R M
The nuclear receptor superfamily: the second decade.
Cell 1995;83(6):835-9.
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1995: Harmon M A; Boehm M F; Heyman R A; Mangelsdorf D J
Activation of mammalian retinoid X receptors by the insect growth regulator methoprene.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6157-60.
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1995: Willy P J; Umesono K; Ong E S; Evans R M; Heyman R A; Mangelsdorf D J
LXR, a nuclear receptor that defines a distinct retinoid response pathway.
Genes & development 1995;9(9):1033-45.
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1994: Kliewer S A; Forman B M; Blumberg B; Ong E S; Borgmeyer U; Mangelsdorf D J; Umesono K; Evans R M
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7355-9.
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1994: Almasan A; Mangelsdorf D J; Ong E S; Wahl G M; Evans R M
Chromosomal localization of the human retinoid X receptors.
Genomics 1994;20(3):397-403.
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1994: Boehm M F; McClurg M R; Pathirana C; Mangelsdorf D; White S K; Hebert J; Winn D; Goldman M E; Heyman R A
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.
Journal of medicinal chemistry 1994;37(3):408-14.
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1993: Mangelsdorf D J; Kliewer S A; Kakizuka A; Umesono K; Evans R M
Retinoid receptors.
Recent progress in hormone research 1993;48():99-121.
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1992: Blumberg B; Mangelsdorf D J; Dyck J A; Bittner D A; Evans R M; De Robertis E M
Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2321-5.
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1992: Mangelsdorf D J; Borgmeyer U; Heyman R A; Zhou J Y; Ong E S; Oro A E; Kakizuka A; Evans R M
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
Genes & development 1992;6(3):329-44.
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1992: Kliewer S A; Umesono K; Heyman R A; Mangelsdorf D J; Dyck J A; Evans R M
Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1448-52.
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1992: Kliewer S A; Umesono K; Mangelsdorf D J; Evans R M
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.
Nature 1992;355(6359):446-9.
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1992: Heyman R A; Mangelsdorf D J; Dyck J A; Stein R B; Eichele G; Evans R M; Thaller C
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.
Cell 1992;68(2):397-406.
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1991: Mangelsdorf D J; Umesono K; Kliewer S A; Borgmeyer U; Ong E S; Evans R M
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
Cell 1991;66(3):555-61.
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1991: Yang N; Schüle R; Mangelsdorf D J; Evans R M
Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3559-63.
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1990: Ishikawa T; Umesono K; Mangelsdorf D J; Aburatani H; Stanger B Z; Shibasaki Y; Imawari M; Evans R M; Takaku F
A functional retinoic acid receptor encoded by the gene on human chromosome 12.
Molecular endocrinology (Baltimore, Md.) 1990;4(6):837-44.
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1990: Schüle R; Umesono K; Mangelsdorf D J; Bolado J; Pike J W; Evans R M
Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene.
Cell 1990;61(3):497-504.
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1990: Mangelsdorf D J; Ong E S; Dyck J A; Evans R M
Nuclear receptor that identifies a novel retinoic acid response pathway.
Nature 1990;345(6272):224-9.
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1989: Merke J; Milde P; Lewicka S; Hügel U; Klaus G; Mangelsdorf D J; Haussler M R; Rauterberg E W; Ritz E
Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries.
The Journal of clinical investigation 1989;83(6):1903-15.
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