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David Mangelsdorf

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Stan D Atkin; Angie L Bookout; Roberta M Cravo; Carol F Elias; Joel K Elmquist; Steven A Kliewer; Charlotte Lee; Bryn M Owen; David J Mangelsdorf
Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.
Sungsoo Lee; David J Mangelsdorf; Richard G W Anderson; Yangsik Jeong; Ping-Yuan Wang; Peter Michaely
Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE.
Xunshan Ding; Jamie Boney-Montoya; Angie L Bookout; Katie Colbert Coate; David J Mangelsdorf; Bryn M Owen; Steven A Kliewer
βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism.

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2013: Stan D Atkin; Angie L Bookout; Roberta M Cravo; Carol F Elias; Joel K Elmquist; Steven A Kliewer; Charlotte Lee; Bryn M Owen; David J Mangelsdorf
Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.
Molecular endocrinology (Baltimore, Md.) 2013;27(4):598-605.
2012: Sungsoo Lee; David J Mangelsdorf; Richard G W Anderson; Yangsik Jeong; Ping-Yuan Wang; Peter Michaely
Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE.
Experimental cell research 2012;318(16):2128-42.
2012: Xunshan Ding; Jamie Boney-Montoya; Angie L Bookout; Katie Colbert Coate; David J Mangelsdorf; Bryn M Owen; Steven A Kliewer
βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism.
Cell metabolism 2012;16(3):387-93.
2012: Yangsik Jeong; Woochang Lee; Carmen Behrens; Angie L Bookout; Adi F Gadzar; Luc Girard; John D Minna; Gabriela Raso; Ignacio I Wistuba; Yang Xie; David J Mangelsdorf
Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer.
Molecular endocrinology (Baltimore, Md.) 2012;26(8):1443-54.
2012: Wei Wei; Xunde Wang; Xueqian Wang; Angie L Bookout; Paul C Dechow; Xunshan Ding; Paul Anthony Dutchak; Robert D Gerard; Regina Goetz; Steven A Kliewer; David J Mangelsdorf; Moosa Mohammadi; Yihong Wan
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):3143-8.
2012: Xiaoyong Zhi; X Edward Zhou; Verena Gelmedin; John Hawdon; Steven A Kliewer; David J Mangelsdorf; Karsten Melcher; Daniel L Motola; H Eric Xu
Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes.
The Journal of biological chemistry 2012;287(7):4894-903.
2012: Paul Anthony Dutchak; Takeshi Katafuchi; Angie L Bookout; Jang Hyun Choi; David J Mangelsdorf; Ruth T Yu; Steven A Kliewer
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.
Cell 2012;148(3):556-67.
2012: Yuan Zhang; Eric D Berglund; Katie Colbert Coate; Ronald M Evans; Tian-Teng He; Takeshi Katafuchi; Steven A Kliewer; Matthew J Potthoff; Yihong Wan; Wei Wei; Guanghua Xiao; Yang Xie; Ruth T Yu; David J Mangelsdorf
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.
eLife 2012;1():e00065.
2011: Joshua Wollam; Carolyn L Cummins; Daniel B Magner; Lilia Magomedova; David J Mangelsdorf; Daniel L Motola; Veerle Rottiers; Yidong Shen; Adam Antebi
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.
Aging cell 2011;10(5):879-84.
2011: Sam R Holmstrom; Steven A Kliewer; David J Mangelsdorf; Frank J Poelwijk; Galvin H Swift; Tye Deering; Raymond J MacDonald
LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.
Genes & development 2011;25(16):1674-9.
2011: Matthew J Potthoff; Jamie Boney-Montoya; Mihwa Choi; Tianteng He; Nishanth E Sunny; Santhosh Satapati; Kelly Suino-Powell; H Eric Xu; Robert D Gerard; Brian N Finck; Shawn C Burgess; David J Mangelsdorf; Steven A Kliewer
FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway.
Cell metabolism 2011;13(6):729-38.
2011: Tingting Li; Sam R Holmstrom; Serkan Kir; Michihisa Umetani; Daniel R Schmidt; Steven A Kliewer; David J Mangelsdorf
The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling.
Molecular endocrinology (Baltimore, Md.) 2011;25(6):1066-71.
2011: Serkan Kir; Sara A Beddow; Varman T Samuel; Paul Miller; Stephen F Previs; Kelly Suino-Powell; H Eric Xu; Gerald I Shulman; Steven A Kliewer; David J Mangelsdorf
FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.
Science (New York, N.Y.) 2011;331(6024):1621-4.
2011: Rucha Patel; Monika Patel; Ricky Tsai; Vicky Lin; Angie L Bookout; Yuan Zhang; Lilia Magomedova; Tingting Li; Jessica F Chan; Conrad Budd; David J Mangelsdorf; Carolyn L Cummins
LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.
The Journal of clinical investigation 2011;121(1):431-41.
2010: David J Mangelsdorf
Commentary: the year in nuclear receptor control of metabolism.
Molecular endocrinology (Baltimore, Md.) 2010;24(11):2075-80.
2010: Klementina Fon Tacer; Angie L Bookout; Xunshan Ding; Hiroshi Kurosu; George B John; Lei Wang; Regina Goetz; Moosa Mohammadi; Makoto Kuro-o; David J Mangelsdorf; Steven A Kliewer
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.
Molecular endocrinology (Baltimore, Md.) 2010;24(10):2050-64.
2010: Susan Holbeck; Jianjun Chang; Anne M Best; Angie L Bookout; David J Mangelsdorf; Elisabeth D Martinez
Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions.
Molecular endocrinology (Baltimore, Md.) 2010;24(6):1287-96.
2010: Daniel R Schmidt; Sam R Holmstrom; Klementina Fon Tacer; Angie L Bookout; Steven A Kliewer; David J Mangelsdorf
Regulation of bile acid synthesis by fat-soluble vitamins A and D.
The Journal of biological chemistry 2010;285(19):14486-94.
2010: Yangsik Jeong; Yang Xie; Guanghua Xiao; Carmen Behrens; Luc Girard; Ignacio I Wistuba; John D Minna; David J Mangelsdorf
Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer.
PLoS medicine 2010;7(12):e1000378.
2010: Steven A Kliewer; David J Mangelsdorf
Fibroblast growth factor 21: from pharmacology to physiology.
The American journal of clinical nutrition 2010;91(1):254S-257S.
2009: Yangsik Jeong; David J Mangelsdorf
Nuclear receptor regulation of stemness and stem cell differentiation.
Experimental & molecular medicine 2009;41(8):525-37.
2009: Matthew J Potthoff; Takeshi Inagaki; Santhosh Satapati; Xunshan Ding; Tianteng He; Regina Goetz; Moosa Mohammadi; Brian N Finck; David J Mangelsdorf; Steven A Kliewer; Shawn C Burgess
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(26):10853-8.
2009: Zhu Wang; X Edward Zhou; Daniel L Motola; Xin Gao; Kelly Suino-Powell; Aoife Conneely; Craig Ogata; Kamalesh K Sharma; Richard J Auchus; James B Lok; John M Hawdon; Steven A Kliewer; H Eric Xu; David J Mangelsdorf
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9138-43.
2009: Neil J McKenna; Austin J Cooney; Francesco J DeMayo; Michael Downes; Christopher K Glass; Rainer B Lanz; Mitchell Lazar; David J Mangelsdorf; David D Moore; Jun Qin; David L Steffen; Ming-Jer Tsai; Sophia Y Tsai; Ruth Yu; Ronald N Margolis; Ronald M Evans; Bert W O'Malley
Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas.
Molecular endocrinology (Baltimore, Md.) 2009;23(6):740-6.
2009: Tingwan Sun; Mingui Fu; Angie L Bookout; Steven A Kliewer; David J Mangelsdorf
MicroRNA let-7 regulates 3T3-L1 adipogenesis.
Molecular endocrinology (Baltimore, Md.) 2009;23(6):925-31.
2009: Kamalesh K Sharma; Zhu Wang; Daniel L Motola; Carolyn L Cummins; David J Mangelsdorf; Richard J Auchus
Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.
Molecular endocrinology (Baltimore, Md.) 2009;23(5):640-8.
2009: Changqing Xie; Yangsik Jeong; Mingui Fu; Angie L Bookout; Minerva Garcia-Barrio; Tingwan Sun; Bong-Hyun Kim; Yang Xie; Sierra Root; Jifeng Zhang; Ren-He Xu; Chen Lab; David J Mangelsdorf
Expression profiling of nuclear receptors in human and mouse embryonic stem cells.
Molecular endocrinology (Baltimore, Md.) 2009;23(5):724-33.
2009: Axel Bethke; Nicole Fielenbach; Zhu Wang; David J Mangelsdorf; Adam Antebi
Nuclear hormone receptor regulation of microRNAs controls developmental progression.
Science (New York, N.Y.) 2009;324(5923):95-8.
2008: Daniel R Schmidt; David J Mangelsdorf
Nuclear receptors of the enteric tract: guarding the frontier.
Nutrition reviews 2008;66(10 Suppl 2):S88-97.
2008: Santhosh Satapati; Tianteng He; Takeshi Inagaki; Matthew Potthoff; Matthew E Merritt; Victoria Esser; David J Mangelsdorf; Steven A Kliewer; Jeffrey D Browning; Shawn C Burgess
Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.
Diabetes 2008;57(8):2012-21.
2008: Takeshi Inagaki; Vicky Y Lin; Regina Goetz; Moosa Mohammadi; David J Mangelsdorf; Steven A Kliewer
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.
Cell metabolism 2008;8(1):77-83.
2008: Youn-Kyoung Lee; Daniel R Schmidt; Carolyn L Cummins; Mihwa Choi; Li Peng; Yuan Zhang; Bryan Goodwin; Robert E Hammer; David J Mangelsdorf; Steven A Kliewer
Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.
Molecular endocrinology (Baltimore, Md.) 2008;22(6):1345-56.
2008: Haibo Wang; Yuan Zhang; Einav Yehuda-Shnaidman; Alexander V Medvedev; Naresh Kumar; Kiefer W Daniel; jacques robidoux; Michael P Czech; David J Mangelsdorf; Sheila Collins
Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.
Molecular and cellular biology 2008;28(7):2187-200.
2008: Carolyn D DuSell; Michihisa Umetani; Philip W Shaul; David J Mangelsdorf; Donald P McDonnell
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.
Molecular endocrinology (Baltimore, Md.) 2008;22(1):65-77.
2007: Diana Jung; Takeshi Inagaki; Robert D Gerard; Paul A Dawson; Steven A Kliewer; David J Mangelsdorf; Antonio Moschetta
FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.
Journal of lipid research 2007;48(12):2693-700.
2007: Michihisa Umetani; Hideharu Domoto; Andrew K Gormley; Ivan S Yuhanna; Carolyn L Cummins; Norman B Javitt; Kenneth S Korach; Philip W Shaul; David J Mangelsdorf
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.
Nature medicine 2007;13(10):1185-92.
2007: Takeshi Inagaki; Paul Anthony Dutchak; Guixiang Zhao; Xunshan Ding; Laurent Gautron; Vinay Parameswara; Yong Li; Regina Goetz; Moosa Mohammadi; Victoria Esser; Joel K Elmquist; Robert D Gerard; Shawn C Burgess; Robert E Hammer; David J Mangelsdorf; Steven A Kliewer
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.
Cell metabolism 2007;5(6):415-25.
2007: Sander M Houten; David H Volle; Carolyn L Cummins; David J Mangelsdorf; Johan Auwerx
In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.
Molecular endocrinology (Baltimore, Md.) 2007;21(6):1312-23.
2007: Birgit Gerisch; Veerle Rottiers; Dongling Li; Daniel L Motola; Carolyn L Cummins; Hans Lehrach; David J Mangelsdorf; Adam Antebi
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5014-9.
2007: Keith D Baker; Robert B Beckstead; David J Mangelsdorf; Carl S Thummel
Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila.
Genes & development 2007;21(4):450-64.
2007: Wenling Chen; Guoxen Chen; Daphne L Head; David J Mangelsdorf; David W Russell
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.
Cell metabolism 2007;5(1):73-9.
2006: Pierre Germain; Pierre Chambon; Gregor Eichele; Ronald M Evans; Mitchell Lazar; Mark Leid; Angel R de Lera; Reuben Lotan; David J Mangelsdorf; Hinrich Gronemeyer
International Union of Pharmacology. LXIII. Retinoid X receptors.
Pharmacological reviews 2006;58(4):760-72.
2006: David D Moore; Shigeaki Kato; Wen Xie; David J Mangelsdorf; Daniel R Schmidt; Rui Xiao; Steven A Kliewer
International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.
Pharmacological reviews 2006;58(4):742-59.
2006: Pierre Germain; Pierre Chambon; Gregor Eichele; Ronald M Evans; Mitchell Lazar; Mark Leid; Angel R de Lera; Reuben Lotan; David J Mangelsdorf; Hinrich Gronemeyer
International Union of Pharmacology. LX. Retinoic acid receptors.
Pharmacological reviews 2006;58(4):712-25.
2006: Carolyn L Cummins; David J Mangelsdorf
Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland.
Biochemical Society transactions 2006;34(Pt 6):1110-3.
2006: Mihwa Choi; Antonio Moschetta; Angie L Bookout; Li Peng; Michihisa Umetani; Sam R Holmstrom; Kelly Suino-Powell; H Eric Xu; James A Richardson; Robert D Gerard; David J Mangelsdorf; Steven A Kliewer
Identification of a hormonal basis for gallbladder filling.
Nature medicine 2006;12(11):1253-5.
2006: Chendong Yang; Jeffrey G McDonald; Amit Patel; Yuan Zhang; Michihisa Umetani; Fang Xu; Emily J Westover; Douglas F Covey; David J Mangelsdorf; Jonathan C Cohen; Helen H Hobbs
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.
The Journal of biological chemistry 2006;281(38):27816-26.
2006: Xiaoyong Yang; Michael Downes; Ruth T Yu; Angie L Bookout; Weimin He; Marty Straume; David J Mangelsdorf; Ronald M Evans
Nuclear receptor expression links the circadian clock to metabolism.
Cell 2006;126(4):801-10.
2006: Angie L Bookout; Yangsik Jeong; Michael Downes; Ruth T Yu; Ronald M Evans; David J Mangelsdorf
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network.
Cell 2006;126(4):789-99.
2006: Carolyn L Cummins; David H Volle; Yuan Zhang; Jeffrey G McDonald; Benoît Sion; Anne-Marie Lefrançois-Martinez; Françoise Caira; Georges Veyssière; David J Mangelsdorf; Jean-Marc Lobaccaro
Liver X receptors regulate adrenal cholesterol balance.
The Journal of clinical investigation 2006;116(7):1902-12.
2006: Veerle Rottiers; Daniel L Motola; Birgit Gerisch; Carolyn L Cummins; Kiyoji Nishiwaki; David J Mangelsdorf; Adam Antebi
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.
Developmental cell 2006;10(4):473-82.
2006: Daniel L Motola; Carolyn L Cummins; Veerle Rottiers; Kamalesh K Sharma; Tingting Li; Yong Li; Kelly Suino-Powell; H Eric Xu; Richard J Auchus; Adam Antebi; David J Mangelsdorf
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.
Cell 2006;124(6):1209-23.
2006: Takeshi Inagaki; Antonio Moschetta; Youn-Kyoung Lee; Li Peng; Guixiang Zhao; Michael Downes; Ruth T Yu; John M Shelton; James A Richardson; Joyce J Repa; David J Mangelsdorf; Steven A Kliewer
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3920-5.
2006: Angie L Bookout; Carolyn L Cummins; David J Mangelsdorf; Jean M Pesola; Martha F Kramer
High-throughput real-time quantitative reverse transcription PCR.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2006;Chapter 15():Unit 15.8.
2006: Nada Y Kalaany; David J Mangelsdorf
LXRS and FXR: the yin and yang of cholesterol and fat metabolism.
Annual review of physiology 2006;68():159-91.
2005: Takeshi Inagaki; Mihwa Choi; Antonio Moschetta; Li Peng; Carolyn L Cummins; Jeffrey G McDonald; Guizhen Luo; Stacey A Jones; Bryan Goodwin; James A Richardson; Robert D Gerard; Joyce J Repa; David J Mangelsdorf; Steven A Kliewer
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Cell metabolism 2005;2(4):217-25.
2005: Grant D Barish; Michael Downes; William Alaynick; Ruth T Yu; Corinne B Ocampo; Angie L Bookout; David J Mangelsdorf; Ronald M Evans
A Nuclear Receptor Atlas: macrophage activation.
Molecular endocrinology (Baltimore, Md.) 2005;19(10):2466-77.
2005: Mingui Fu; Tingwan Sun; Angie L Bookout; Michael Downes; Ruth T Yu; Ronald M Evans; David J Mangelsdorf
A Nuclear Receptor Atlas: 3T3-L1 adipogenesis.
Molecular endocrinology (Baltimore, Md.) 2005;19(10):2437-50.
2005: Andrew I Shulman; David J Mangelsdorf
Retinoid x receptor heterodimers in the metabolic syndrome.
The New England journal of medicine 2005;353(6):604-15.
2005: Nada Y Kalaany; Karine C Gauthier; Ann Marie Zavacki; Pradeep P.A. Mammen; Tatsuya Kitazume; Julian A Peterson; Jay D Horton; Daniel J Garry; Antonio Bianco; David J Mangelsdorf
LXRs regulate the balance between fat storage and oxidation.
Cell metabolism 2005;1(4):231-44.
2005: Liqing Yu; Sarita Gupta; Fang Xu; Amy D B Liverman; Antonio Moschetta; David J Mangelsdorf; Joyce J Repa; Helen H Hobbs; Jonathan C Cohen
Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion.
The Journal of biological chemistry 2005;280(10):8742-7.
2005: Satoko Arai; John M Shelton; Mingyi Chen; Michelle N Bradley; Antonio Castrillo; Angie L Bookout; Puiying A Mak; Peter A Edwards; David J Mangelsdorf; Peter Tontonoz; Toru Miyazaki
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.
Cell metabolism 2005;1(3):201-13.
2005: Geoffroy Marceau; David H Volle; Denis Gallot; David J Mangelsdorf; Vincent Sapin; Jean-Marc Lobaccaro
Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2005;283(1):175-81.
2004: Antonio Moschetta; Angie L Bookout; David J Mangelsdorf
Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.
Nature medicine 2004;10(12):1352-8.
2004: Jean-Marie Frenoux; Patrick Vernet; David H Volle; Aurore Britan; Fabrice Saez; A Kocer; Joelle Henry-Berger; David J Mangelsdorf; Jean-Marc Lobaccaro; Joel Drevet
Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.
Journal of molecular endocrinology 2004;33(2):361-75.
2004: Jeffrey B Cheng; Michael A. Levine; Norman H Bell; David J Mangelsdorf; David W Russell
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(20):7711-5.
2004: Mitsuhiro Watanabe; Sander M Houten; Li Wang; Antonio Moschetta; David J Mangelsdorf; Richard A Heyman; David D Moore; Johan Auwerx
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.
The Journal of clinical investigation 2004;113(10):1408-18.
2004: David H Volle; Joyce J Repa; Andrzej Mazur; Carolyn L Cummins; Pierre Val; Joelle Henry-Berger; Francoise Caira; Georges Veyssiere; David J Mangelsdorf; Jean-Marc Lobaccaro
Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.
Molecular endocrinology (Baltimore, Md.) 2004;18(4):888-98.
2004: Yuan Zhang; Joyce J Repa; Yusuke Inoue; Graham P Hayhurst; Frank J Gonzalez; David J Mangelsdorf
Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors.
Molecular endocrinology (Baltimore, Md.) 2004;18(4):851-62.
2004: Andrew I Shulman; Christopher Larson; David J Mangelsdorf; Rama Ranganathan
Structural determinants of allosteric ligand activation in RXR heterodimers.
Cell 2004;116(3):417-29.
2003: Margaret M Hinshelwood; Joyce J Repa; John M Shelton; James A Richardson; David J Mangelsdorf; Carole R Mendelson
Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function.
Molecular and cellular endocrinology 2003;207(1-2):39-45.
2003: Jeffrey B Cheng; Daniel L Motola; David J Mangelsdorf; David W Russell
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase.
The Journal of biological chemistry 2003;278(39):38084-93.
2003: Keith D Baker; Lisa M Shewchuk; Tatiana Kozlova; Makoto Makishima; Annie Hassell; Bruce Wisely; Justin A Caravella; Millard H Lambert; Jeffrey L Reinking; Henry Krause; Carl S Thummel; Timothy M Willson; David J Mangelsdorf
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway.
Cell 2003;113(6):731-42.
2003: Peter Tontonoz; David J Mangelsdorf
Liver X receptor signaling pathways in cardiovascular disease.
Molecular endocrinology (Baltimore, Md.) 2003;17(6):985-93.
2003: Bryan A Laffitte; Lily C Chao; Jing Li; Robert Walczak; Sarah Hummasti; Sean B Joseph; Antonio Castrillo; DAMIEN WILPITZ; David J Mangelsdorf; Jon L Collins; Enrique Saez; Peter Tontonoz
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5419-24.
2003: Antonio Castrillo; Sean B Joseph; Chaitra Marathe; David J Mangelsdorf; Peter Tontonoz
Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages.
The Journal of biological chemistry 2003;278(12):10443-9.
2003: Sean B Joseph; Antonio Castrillo; Bryan A Laffitte; David J Mangelsdorf; Peter Tontonoz
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.
Nature medicine 2003;9(2):213-9.
2003: Bryan Goodwin; Karine C Gauthier; Michihisa Umetani; Michael A Watson; Matthew I Lochansky; Jon L Collins; eran leitersdorf; David J Mangelsdorf; Steven A Kliewer; Joyce J Repa
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):223-8.
2003: Angie L Bookout; David J Mangelsdorf
Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways.
Nuclear receptor signaling 2003;1():e012.
2002: Joyce J Repa; David J Mangelsdorf
The liver X receptor gene team: potential new players in atherosclerosis.
Nature medicine 2002;8(11):1243-8.
2002: Young Lee; Xinxin Yu; F Gonzales; David J Mangelsdorf; May-Yun Wang; C Richardson; L A Witters; Roger H Unger
PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11848-53.
2002: Rajendra K Tangirala; Eric D Bischoff; Sean B Joseph; Brandee L Wagner; Robert Walczak; Bryan A Laffitte; Chris L Daige; Diane Thomas; Richard A Heyman; David J Mangelsdorf; Xuping Wang; Aldons J Lusis; Peter Tontonoz; Ira G Schulman
Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11896-901.
2002: Puiying A Mak; Bryan A Laffitte; Catherine Desrumaux; Sean B Joseph; Linda K Curtiss; David J Mangelsdorf; Peter Tontonoz; Peter A Edwards
Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
The Journal of biological chemistry 2002;277(35):31900-8.
2002: Nancy L Urizar; Amy B Liverman; D'Nette T Dodds; Frank Valentin Silva; Peter Ordentlich; Yingzhuo Yan; Frank J Gonzalez; Richard A Heyman; David J Mangelsdorf; David D Moore
A natural product that lowers cholesterol as an antagonist ligand for FXR.
Science (New York, N.Y.) 2002;296(5573):1703-6.
2002: Joyce J Repa; Knut E Berge; Chris Pomajzl; James A Richardson; Helen H Hobbs; David J Mangelsdorf
Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.
The Journal of biological chemistry 2002;277(21):18793-800.
2002: Makoto Makishima; Theresa T Lu; Wen Xie; G Kerr Whitfield; Hideharu Domoto; Ronald M Evans; Mark R Haussler; David J Mangelsdorf
Vitamin D receptor as an intestinal bile acid sensor.
Science (New York, N.Y.) 2002;296(5571):1313-6.
2002: Yuan Zhang; David J Mangelsdorf
LuXuRies of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing.
Molecular interventions 2002;2(2):78-87.
2001: Donald F Doyle; Dwaine A Braasch; L K Jackson; H E Weiss; M F Boehm; David J Mangelsdorf; David R Corey
Engineering orthogonal ligand-receptor pairs from "near drugs".
Journal of the American Chemical Society 2001;123(46):11367-71.
2001: Yuan Zhang; Joyce J Repa; Karine C Gauthier; David J Mangelsdorf
Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.
The Journal of biological chemistry 2001;276(46):43018-24.
2001: Theresa T Lu; Joyce J Repa; David J Mangelsdorf
Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism.
The Journal of biological chemistry 2001;276(41):37735-8.
2001: Jean-Marc Lobaccaro; Joyce J Repa; Theresa T Lu; F Caira; Joelle Henry-Berger; David H Volle; David J Mangelsdorf
[Regulation of lipid metabolism by the orphan nuclear receptors].
Annales d'endocrinologie 2001;62(3):239-47.
2001: Bryan A Laffitte; Joyce J Repa; Sean B Joseph; DAMIEN WILPITZ; Heidi R Kast; David J Mangelsdorf; Peter Tontonoz
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):507-12.
2000: J R Schultz; Huiping Tu; A Luk; Joyce J Repa; Julio C Medina; Leping Li; S Schwendner; S Wang; M Thoolen; David J Mangelsdorf; KD Lustig; Bei Shan
Role of LXRs in control of lipogenesis.
Genes & development 2000;14(22):2831-8.
2000: Joyce J Repa; Guosheng Liang; Jiafu Ou; Yuriy Bashmakov; Jean-Marc Lobaccaro; Iichiro Shimomura; Bei Shan; Michael S Brown; Joseph L Goldstein; David J Mangelsdorf
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
Genes & development 2000;14(22):2819-30.
2000: Keith D Baker; James T Warren; Carl S Thummel; Lawrence I Gilbert; David J Mangelsdorf
Transcriptional activation of the Drosophila ecdysone receptor by insect and plant ecdysteroids.
Insect biochemistry and molecular biology 2000;30(11):1037-43.
2000: Theresa T Lu; Makoto Makishima; Joyce J Repa; K Schoonjans; Thomas A Kerr; J Auwerx; David J Mangelsdorf
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.
Molecular cell 2000;6(3):507-15.
2000: Joyce J Repa; Stephen D Turley; Jean-Marc Lobaccaro; J Medina; Linheng Li; KD Lustig; Bei Shan; R A Heyman; John M Dietschy; David J Mangelsdorf
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
Science (New York, N.Y.) 2000;289(5484):1524-9.
2000: A Venkateswaran; Joyce J Repa; Jean-Marc Lobaccaro; A Bronson; David J Mangelsdorf; Peter A Edwards
Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols.
The Journal of biological chemistry 2000;275(19):14700-7.
2000: Donald F Doyle; David J Mangelsdorf; David R Corey
Modifying ligand specificity of gene regulatory proteins.
Current opinion in chemical biology 2000;4(1):60-3.
1999: Makoto Makishima; A Y Okamoto; Joyce J Repa; Huiping Tu; RM Learned; A Luk; M V Hull; KD Lustig; David J Mangelsdorf; Bei Shan
Identification of a nuclear receptor for bile acids.
Science (New York, N.Y.) 1999;284(5418):1362-5.
1999: Bethany A Janowski; Michael J Grogan; Stacey A Jones; G Bruce Wisely; Steven A Kliewer; EJ Corey; David J Mangelsdorf
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):266-71.
1998: DJ Peet; Bethany A Janowski; David J Mangelsdorf
The LXRs: a new class of oxysterol receptors.
Current opinion in genetics & development 1998;8(5):571-5.
1998: May-Yun Wang; K Koyama; Michio Shimabukuro; David J Mangelsdorf; Christopher B Newgard; Roger H Unger
Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11921-6.
1998: DJ Peet; Stephen D Turley; W Ma; Bethany A Janowski; Jean-Marc Lobaccaro; Robert E Hammer; David J Mangelsdorf
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha.
Cell 1998;93(5):693-704.
1998: DJ Peet; Donald F Doyle; David R Corey; David J Mangelsdorf
Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR.
Chemistry & biology 1998;5(1):13-21.
1997: Margaret Harmon; T C Scott; Y Li; M F Boehm; Margaret A Phillips; David J Mangelsdorf
Trypanosoma brucei: effects of methoprene and other isoprenoid compounds on procyclic and bloodstream forms in vitro and in mice.
Experimental parasitology 1997;87(3):229-36.
1997: P J Willy; David J Mangelsdorf
Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.
Genes & development 1997;11(3):289-98.
1996: Bethany A Janowski; P J Willy; T R Devi; J R Falck; David J Mangelsdorf
An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha.
Nature 1996;383(6602):728-31.
1995: David J Mangelsdorf; Ronald M Evans
The RXR heterodimers and orphan receptors.
Cell 1995;83(6):841-50.
1995: David J Mangelsdorf; Carl S Thummel; M Beato; P Herrlich; G Schütz; Kazuhiko Umesono; B Blumberg; P Kastner; M Mark; P Chambon; Ronald M Evans
The nuclear receptor superfamily: the second decade.
Cell 1995;83(6):835-9.
1995: Margaret Harmon; Marcus F Boehm; Richard A Heyman; David J Mangelsdorf
Activation of mammalian retinoid X receptors by the insect growth regulator methoprene.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6157-60.
1995: P J Willy; Kazuhiko Umesono; Estelita S Ong; Ronald M Evans; Richard A Heyman; David J Mangelsdorf
LXR, a nuclear receptor that defines a distinct retinoid response pathway.
Genes & development 1995;9(9):1033-45.
1994: Steven A Kliewer; B M Forman; B Blumberg; Estelita S Ong; U Borgmeyer; David J Mangelsdorf; Kazuhiko Umesono; Ronald M Evans
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7355-9.
1994: alex almasan; David J Mangelsdorf; Estelita S Ong; Geoffrey M Wahl; Ronald M Evans
Chromosomal localization of the human retinoid X receptors.
Genomics 1994;20(3):397-403.
1994: Marcus F Boehm; M R McClurg; C Pathirana; David J Mangelsdorf; Steven White; J Hebert; D Winn; M E Goldman; Richard A Heyman
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.
Journal of medicinal chemistry 1994;37(3):408-14.
1993: David J Mangelsdorf; Steven A Kliewer; A Kakizuka; Kazuhiko Umesono; Ronald M Evans
Retinoid receptors.
Recent progress in hormone research 1993;48():99-121.
1992: B Blumberg; David J Mangelsdorf; J A Dyck; D A Bittner; Ronald M Evans; Edward M De Robertis
Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2321-5.
1992: David J Mangelsdorf; U Borgmeyer; Richard A Heyman; J Y Zhou; Estelita S Ong; A E Oro; A Kakizuka; Ronald M Evans
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
Genes & development 1992;6(3):329-44.
1992: Steven A Kliewer; Kazuhiko Umesono; R A Heyman; David J Mangelsdorf; J A Dyck; Ronald M Evans
Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1448-52.
1992: Steven A Kliewer; Kazuhiko Umesono; David J Mangelsdorf; Ronald M Evans
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.
Nature 1992;355(6359):446-9.
1992: R A Heyman; David J Mangelsdorf; J A Dyck; R B Stein; Gregor Eichele; Ronald M Evans; Christina Thaller
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.
Cell 1992;68(2):397-406.
1991: David J Mangelsdorf; Kazuhiko Umesono; Steven A Kliewer; U Borgmeyer; Estelita S Ong; Ronald M Evans
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
Cell 1991;66(3):555-61.
1991: N Yang; R Schüle; David J Mangelsdorf; Ronald M Evans
Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3559-63.
1990: T Ishikawa; Kazuhiko Umesono; David J Mangelsdorf; Hiroyuki Aburatani; B Z Stanger; Y Shibasaki; M Imawari; Ronald M Evans; F Takaku
A functional retinoic acid receptor encoded by the gene on human chromosome 12.
Molecular endocrinology (Baltimore, Md.) 1990;4(6):837-44.
1990: David J Mangelsdorf; Estelita S Ong; J A Dyck; Ronald M Evans
Nuclear receptor that identifies a novel retinoic acid response pathway.
Nature 1990;345(6272):224-9.
1990: R Schüle; Kazuhiko Umesono; David J Mangelsdorf; J Bolado; J W Pike; Ronald M Evans
Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene.
Cell 1990;61(3):497-504.
1989: J Merke; P Milde; S Lewicka; Ulrike Hügel; Günter Klaus; David J Mangelsdorf; M R Haussler; E W Rauterberg; Eberhard Ritz
Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries.
The Journal of clinical investigation 1989;83(6):1903-15.