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Husseini Manji

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Wallace C Duncan; Fabio Ferrarelli; Nadia S Hejazi; Husseini K Manji; Brady A Riedner; Simone Sarasso; Jessica Selter; Giulio Tononi; Peixiong Yuan; Nancy Brutsche; Carlos A Zarate
Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder.
Vaibhav A Narayan; Gary Pisano; Michael Yang; Marco Mohwinckel; Husseini K Manji
Beyond magic bullets: true innovation in health care.
Harold W Koenigsberg; Husseini K Manji; Sarahjo Mayson; Antonia S New; George A Diaz; Christine Dorantes; Marianne Goodman; Stephanie Guerreri; Peixiong Yuan; Constantin Zamfirescu; Larry J Siever
Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients.

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2013: Wallace C Duncan; Fabio Ferrarelli; Nadia S Hejazi; Husseini K Manji; Brady A Riedner; Simone Sarasso; Jessica Selter; Giulio Tononi; Peixiong Yuan; Nancy Brutsche; Carlos A Zarate
Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2013;16(2):301-11.
2013: Vaibhav A Narayan; Gary Pisano; Michael Yang; Marco Mohwinckel; Husseini K Manji
Beyond magic bullets: true innovation in health care.
Nature reviews. Drug discovery 2013;12(2):85-6.
2012: Harold W Koenigsberg; Husseini K Manji; Sarahjo Mayson; Antonia S New; George A Diaz; Christine Dorantes; Marianne Goodman; Stephanie Guerreri; Peixiong Yuan; Constantin Zamfirescu; Larry J Siever
Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients.
Psychiatry research 2012;199(2):92-7.
2012: Oz Malkesman; Husseini K Manji; Kazu Nakazawa; Gregory Rompala; Tyson Tragon; Gang Wang; W Scott Young; Carlos A Zarate; Daniel R Austin; Zhenzhong Cui; Anahita B Hamidi; Guang Chen
Acute D-serine treatment produces antidepressant-like effects in rodents.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2012;15(8):1135-48.
2012: Andrea de Bartolomeis; Carmine Tomasetti; Pei-Xiong Yuan; Maria Cicale; Husseini K Manji
Chronic treatment with lithium or valproate modulates the expression of Homer1b/c and its related genes Shank and Inositol 1,4,5-trisphosphate receptor.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2012;22(7):527-35.
2012: Oz Malkesman; D R Austin; Guang Chen; Ioline D Henter; M Pellecchia; J C Reed; T Tragon; Husseini K Manji
Targeting the BH3-interacting domain death agonist to develop mechanistically unique antidepressants.
Molecular psychiatry 2012;17(8):770-80.
2012: Wendy A Koss; Husseini K Manji; Haim Einat; Robert J Schloesser; David R Rubinow
Estrogen effects on the forced swim test differ in two outbred rat strains.
Physiology & behavior 2012;106(2):81-6.
2012: Lobna Ibrahim; Phillip Kronstein; David Luckenbaugh; Husseini K Manji; Ruin Moaddel; Irving Wainer; Nancy Brutsche; Nancy Diazgranados; Jose Franco-Chaves; Ioline D Henter; Carlos A Zarate
Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(6):1526-33.
2012: Rima Kaddurah-Daouk; Ranga R Krishnan; Husseini K Manji; Wayne Matson; Alexander Neumeister; Zhi Wang; Jeffrey K Yao; Peixiong Yuan; Carlos Zarate; Zhao-Bang Zeng; Hongjie Zhu; Stephen H Boyle; Paul J Carlson; Guang Chen; George G Dougherty; Xavier Guitart; Wayne Drevets
Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile.
Scientific reports 2012;2():667.
2012: Keri Martinowich; Robert Schloesser; Kathleen M Cardinale; Nigel H Greig; Michael Hsu; Husseini K Manji
Acetylcholinesterase inhibition ameliorates deficits in motivational drive.
Behavioral and brain functions : BBF 2012;8():15.
2012: Robert J Schloesser; Keri Martinowich; Husseini K Manji
Mood-stabilizing drugs: mechanisms of action.
Trends in neurosciences 2012;35(1):36-46.
2012: Keri Martinowich; Daniel Paredes; Robert Schloesser; Yuan Lu; Husseini K Manji; Joshua S Greene; Nigel H Greig; Dennisse V Jimenez; Bai Lu
Roles of p75(NTR), long-term depression, and cholinergic transmission in anxiety and acute stress coping.
Biological psychiatry 2012;71(1):75-83.
2011: Dhaval Nanavati; Daniel R Austin; Lisa A Catapano; Guang Chen; Ayse Dosemeci; David Luckenbaugh; Husseini K Manji; Sanford P Markey
The effects of chronic treatment with mood stabilizers on the rat hippocampal post-synaptic density proteome.
Journal of neurochemistry 2011;119(3):617-29.
2011: Joshua G Hunsberger; Rodrigo Machado-Vieira; Daniel R Austin; Guang Chen; De-Maw Chuang; John C Reed; Carlos Zarate; Husseini K Manji
Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience.
Brain research 2011;1403():19-27.
2011: Thomas K Creson; Husseini K Manji; Joseph McCammon; Galit Shaltiel; Jürgen Wess; Daniel R Austin; Guang Chen
Lithium treatment attenuates muscarinic M(1) receptor dysfunction.
Bipolar disorders 2011;13(3):238-49.
2011: Linda Mah; Carlos A Zarate; Allison C Nugent; Jaskaran B Singh; Husseini K Manji; Wayne C Drevets
Neural mechanisms of antidepressant efficacy of the dopamine receptor agonist pramipexole in treatment of bipolar depression.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2011;14(4):545-51.
2011: Rodrigo Machado-Vieira; Natalia B Pivovarova; Ruslan I Stanika; Peixiong Yuan; Yun Wang; Rulun Zhou; Carlos A Zarate; Wayne C Drevets; Christine A Brantner; Amber Baum; Gonzalo Laje; Francis McMajon; Guang Chen; Jing Du; Husseini K Manji; S Brian Andrews
The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder.
Biological psychiatry 2011;69(4):344-52.
2011: Jonathan B Savitz; Allison Nugent; Wendy Bogers; Jonathan P Roiser; Earle E Bain; Alexander Neumeister; Carlos A Zarate; Husseini K Manji; Dara M Cannon; Sean Marrett; Fritz Henn; Dennis S Charney; Wayne C Drevets
Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study.
Biological psychiatry 2011;69(4):336-43.
2010: Robert Schloesser; M Lehmann; Keri Martinowich; Husseini K Manji; Miles Herkenham
Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress.
Molecular psychiatry 2010;15(12):1152-63.
2010: Giacomo Salvadore; Jorge A Quiroz; Rodrigo Machado-Vieira; Ioline D Henter; Husseini K Manji; Carlos A Zarate
The neurobiology of the switch process in bipolar disorder: a review.
The Journal of clinical psychiatry 2010;71(11):1488-501.
2010: Guang Chen; Roy Twyman; Husseini K Manji
p11 and gene therapy for severe psychiatric disorders: a practical goal?
Science translational medicine 2010;2(54):54ps51.
2010: Guang Chen; Ioline D Henter; Husseini K Manji
Translational research in bipolar disorder: emerging insights from genetically based models.
Molecular psychiatry 2010;15(9):883-95.
2010: Nancy Diazgranados; Lobna Ibrahim; Nancy E Brutsche; Andrew Newberg; Phillip Kronstein; Sami Khalife; William A Kammerer; Zenaide Quezado; David Luckenbaugh; Giacomo Salvadore; Rodrigo Machado-Vieira; Husseini K Manji; Carlos A Zarate
A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.
Archives of general psychiatry 2010;67(8):793-802.
2010: Brian R Cornwell; Giacomo Salvadore; Veronica Colon-Rosario; David R Latov; Tom Holroyd; Frederick W Carver; Richard Coppola; Husseini K Manji; Carlos A Zarate; Christian Grillon
Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals: evidence from whole-head magnetoencephalography.
The American journal of psychiatry 2010;167(7):836-44.
2010: Gonzalo Laje; Dara M Cannon; Andrew S Allen; Jackie M Klaver; Summer A Peck; xinmin liu; Husseini K Manji; Wayne C Drevets; Francis McMajon
Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2010;13(6):715-24.
2010: Peixiong Yuan; Rulun Zhou; Yun Wang; Xiaoxia Li; Jianling Li; Guang Chen; Xavier Guitart; Husseini K Manji
Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia.
Journal of affective disorders 2010;124(1-2):164-9.
2010: Jing Du; Yanling Wei; Lidong Liu; Yun Wang; Rushaniya Khairova; Rayah Blumenthal; Tyson Tragon; Joshua G Hunsberger; Rodrigo Machado-Vieira; Wayne C Drevets; Yu Tian Wang; Husseini K Manji
A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11573-8.
2010: Guang Chen; Ioline D Henter; Husseini K Manji
Presynaptic glutamatergic dysfunction in bipolar disorder.
Biological psychiatry 2010;67(11):1007-9.
2010: Oz Malkesman; Maria Luisa Scattoni; Daniel Paredes; Tyson Tragon; Brandon Pearson; Galit Shaltiel; Guang Chen; Jacqueline N Crawley; Husseini K Manji
The female urine sniffing test: a novel approach for assessing reward-seeking behavior in rodents.
Biological psychiatry 2010;67(9):864-71.
2010: Jens Benninghoff; Angela Gritti; Matteo Rizzi; Giuseppe Lamorte; Robert Schloesser; Angelika Schmitt; Stefanie Robel; Just Genius; Rainald Moessner; Peter Riederer; Husseini K Manji; Heinz Grunze; Dan Rujescu; Hans-Juergen Moeller; Klaus-Peter Lesch; Angelo L Vescovi
Serotonin depletion hampers survival and proliferation in neurospheres derived from adult neural stem cells.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(4):893-903.
2010: Jonathan Savitz; Allison Nugent; Wendy Bogers; Alice Liu; Rebecca Sills; David Luckenbaugh; Earle E Bain; Joseph L Price; Carlos A Zarate; Husseini K Manji; Dara M Cannon; Sean Marrett; Dennis S Charney; Wayne C Drevets
Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication.
NeuroImage 2010;49(4):2966-76.
2010: Jorge A Quiroz; Rodrigo Machado-Vieira; Carlos A Zarate; Husseini K Manji
Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects.
Neuropsychobiology 2010;62(1):50-60.
2010: Tewarit Sarachana; Rulun Zhou; Guang Chen; Husseini K Manji; Valerie W Hu
Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines.
Genome medicine 2010;2(4):23.
2009: Rulun Zhou; Andrew Holmes; Jing Du; Oz Malkesman; Peixiong Yuan; Yun Wang; Patricia Damschroder-Williams; Guang Chen; Xavier Guitart; Husseini K Manji
Genome-wide gene expression profiling in GluR1 knockout mice: key role of the calcium signaling pathway in glutamatergically mediated hippocampal transmission.
The European journal of neuroscience 2009;30(12):2318-26.
2009: Rodrigo Machado-Vieira; Peixiong Yuan; Nancy Brutsche; Nancy DiazGranados; David Luckenbaugh; Husseini K Manji; Carlos A Zarate
Brain-derived neurotrophic factor and initial antidepressant response to an N-methyl-D-aspartate antagonist.
The Journal of clinical psychiatry 2009;70(12):1662-6.
2009: Guang Chen; Ioline D Henter; Husseini K Manji
A role for PKC in mediating stress-induced prefrontal cortical structural plasticity and cognitive function.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17613-4.
2009: Giacomo Salvadore; Allison C Nugent; Guang Chen; Nirmala Akula; Peixiong Yuan; Dara M Cannon; Carlos A Zarate; Francis McMajon; Husseini K Manji; Wayne C Drevets
Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans.
Biological psychiatry 2009;66(8):804-7.
2009: Joshua G Hunsberger; Daniel R Austin; Guang Chen; Husseini K Manji
Cellular mechanisms underlying affective resiliency: the role of glucocorticoid receptor- and mitochondrially-mediated plasticity.
Brain research 2009;1293():76-84.
2009: Rodrigo Machado-Vieira; Husseini K Manji; Carlos A Zarate
The role of the tripartite glutamatergic synapse in the pathophysiology and therapeutics of mood disorders.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2009;15(5):525-39.
2009: Jing Du; Bruce McEwen; Husseini K Manji
Glucocorticoid receptors modulate mitochondrial function: A novel mechanism for neuroprotection.
Communicative & integrative biology 2009;2(4):350-2.
2009: Rosilla F Bachmann; Yun Wang; Peixiong Yuan; Rulun Zhou; Xiaoxia Li; Salvatore Alesci; Jing Du; Husseini K Manji
Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009;12(6):805-22.
2009: Rodrigo Machado-Vieira; Husseini K Manji; Carlos A Zarate
The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis.
Bipolar disorders 2009;11 Suppl 2():92-109.
2009: Thomas K Creson; Yanlei Hao; Sharon Engel; Yi Shen; Anahita Hamidi; Min Zhuo; Husseini K Manji; Guang Chen
The anterior cingulate ERK pathway contributes to regulation of behavioral excitement and hedonic activity.
Bipolar disorders 2009;11(4):339-50.
2009: Peixiong Yuan; Giacomo Salvadore; Xiaoxia Li; Lei Zhang; Jing Du; Guang Chen; Husseini K Manji
Valproate activates the Notch3/c-FLIP signaling cascade: a strategy to attenuate white matter hyperintensities in bipolar disorder in late life?
Bipolar disorders 2009;11(3):256-69.
2009: Oz Malkesman; Daniel R Austin; Guang Chen; Husseini K Manji
Reverse translational strategies for developing animal models of bipolar disorder.
Disease models & mechanisms 2009;2(5-6):238-45.
2009: Gregory Moore; Bernadette M Cortese; Debra A Glitz; Caroline Zajac-Benitez; Jorge A Quiroz; Thomas W Uhde; Wayne C Drevets; Husseini K Manji
A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients.
The Journal of clinical psychiatry 2009;70(5):699-705.
2009: Rushaniya A Khairova; Rodrigo Machado-Vieira; Jing Du; Husseini K Manji
A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009;12(4):561-78.
2009: Rulun Zhou; Peixiong Yuan; Yun Wang; Joshua G Hunsberger; Abdel Elkahloun; Yanling Wei; Patricia Damschroder-Williams; Jing Du; Guang Chen; Husseini K Manji
Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(6):1395-405.
2009: Robert Schloesser; Husseini K Manji; Keri Martinowich
Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response.
Neuroreport 2009;20(6):553-7.
2009: Keri Martinowich; Robert Schloesser; Husseini K Manji
Bipolar disorder: from genes to behavior pathways.
The Journal of clinical investigation 2009;119(4):726-36.
2009: Oz Malkesman; Daniel S Pine; Tyson Tragon; Daniel R Austin; Ioline D Henter; Guang Chen; Husseini K Manji
Animal models of suicide-trait-related behaviors.
Trends in pharmacological sciences 2009;30(4):165-73.
2009: S R Engel; T K Creson; Y Hao; Yong Shen; Sungho Maeng; T Nekrasova; Gary Landreth; Husseini K Manji; Guang Chen
The extracellular signal-regulated kinase pathway contributes to the control of behavioral excitement.
Molecular psychiatry 2009;14(4):448-61.
2009: Jing Du; Yun Wang; Richard Hunter; Yanling Wei; Rayah Blumenthal; Cynthia Falke; Rushaniya Khairova; Rulun Zhou; Peixiong Yuan; Rodrigo Machado-Vieira; Bruce S McEwen; Husseini K Manji
Dynamic regulation of mitochondrial function by glucocorticoids.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3543-8.
2009: Giacomo Salvadore; Brian Cornwell; Veronica Colon-Rosario; Richard Coppola; Christian Grillon; Carlos A Zarate; Husseini K Manji
Increased anterior cingulate cortical activity in response to fearful faces: a neurophysiological biomarker that predicts rapid antidepressant response to ketamine.
Biological psychiatry 2009;65(4):289-95.
2009: Laura E Phelps; Nancy Brutsche; Jazmin R Moral; David Luckenbaugh; Husseini K Manji; Carlos A Zarate
Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist.
Biological psychiatry 2009;65(2):181-4.
2009: Carlos A Zarate; Husseini K Manji
Protein kinase C inhibitors: rationale for use and potential in the treatment of bipolar disorder.
CNS drugs 2009;23(7):569-82.
2009: Joshua G Hunsberger; Daniel R Austin; Guang Chen; Husseini K Manji
MicroRNAs in mental health: from biological underpinnings to potential therapies.
Neuromolecular medicine 2009;11(3):173-82.
2009: Steven Szabo; Rodrigo Machado-Vieira; Peixiong Yuan; Yun Wang; Yanling Wei; Cynthia Falke; Chiara Cirelli; Giulio Tononi; Husseini K Manji; Jing Du
Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania.
Neuropharmacology 2009;56(1):47-55.
2008: ALAN MALLINGER; Michael E Thase; Roger Haskett; Joan Buttenfield; David Luckenbaugh; Ellen Frank; David J Kupfer; Husseini K Manji
Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms.
Bipolar disorders 2008;10(8):856-66.
2008: M Kathleen Holmes; Kristine Erickson; David Luckenbaugh; Wayne C Drevets; Earle E Bain; Dara M Cannon; Joseph Snow; Barbara J Sahakian; Husseini K Manji; Carlos A Zarate
A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression.
Bipolar disorders 2008;10(7):806-15.
2008: Alan J Gelenberg; Michael E Thase; Roger E Meyer; Frederick K Goodwin; Martin M Katz; Helena Chmura Kraemer; William Z Potter; Richard C Shelton; Maurizio Fava; Arif Khan; Madhukar H Trivedi; Philip T Ninan; John J Mann; Susan Bergeson; Jean Endicott; James H Kocsis; Andrew C Leon; Husseini K Manji; Jerrold F Rosenbaum
The history and current state of antidepressant clinical trial design: a call to action for proof-of-concept studies.
The Journal of clinical psychiatry 2008;69(10):1513-28.
2008: Jorge A Quiroz; Neil A Gray; Tadafumi Kato; Husseini K Manji
Mitochondrially mediated plasticity in the pathophysiology and treatment of bipolar disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(11):2551-65.
2008: Carlos A Zarate; Husseini K Manji
Riluzole in psychiatry: a systematic review of the literature.
Expert opinion on drug metabolism & toxicology 2008;4(9):1223-34.
2008: G Shaltiel; Sungho Maeng; O Malkesman; Brandon Pearson; Robert Schloesser; T Tragon; Michael A Rogawski; M Gasior; David Luckenbaugh; Guang Chen; Husseini K Manji
Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania.
Molecular psychiatry 2008;13(9):858-72.
2008: Giacomo Salvadore; Wayne C Drevets; Ioline D Henter; Carlos A Zarate; Husseini K Manji
Early intervention in bipolar disorder, part II: therapeutics.
Early intervention in psychiatry 2008;2(3):136-46.
2008: Giacomo Salvadore; Wayne C Drevets; Ioline D Henter; Carlos A Zarate; Husseini K Manji
Early intervention in bipolar disorder, part I: clinical and imaging findings.
Early intervention in psychiatry 2008;2(3):122-35.
2008: Sanjay J Mathew; Husseini K Manji; Dennis S Charney
Novel drugs and therapeutic targets for severe mood disorders.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(9):2080-92.
2008: Sungho Maeng; Joshua G Hunsberger; Brandon Pearson; Peixiong Yuan; Yun Wang; Yanling Wei; Joseph McCammon; Robert Schloesser; Rulun Zhou; Jing Du; Guang Chen; Bruce McEwen; John C Reed; Husseini K Manji
BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8766-71.
2008: Magnus Lekman; Gonzalo Laje; Dennis Charney; john rush; Alexander F Wilson; Alexa J M Sorant; Robert Lipsky; Stephen R Wisniewski; Husseini K Manji; Francis McMajon; Silvia Paddock
The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort.
Biological psychiatry 2008;63(12):1103-10.
2008: Martin J Lan; Peixiong Yuan; Guang Chen; Husseini K Manji
Neuronal peroxisome proliferator-activated receptor gamma signaling: regulation by mood-stabilizer valproate.
Journal of molecular neuroscience : MN 2008;35(2):225-34.
2008: Rodrigo Machado-Vieira; Giacomo Salvadore; David Luckenbaugh; Husseini K Manji; Carlos A Zarate
Rapid onset of antidepressant action: a new paradigm in the research and treatment of major depressive disorder.
The Journal of clinical psychiatry 2008;69(6):946-58.
2008: Christine E Marx; Peixiong Yuan; Jason D Kilts; Roger D Madison; Lawrence J Shampine; Husseini K Manji
Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2008;11(4):547-52.
2008: Todd D Gould; Kelley C O'Donnell; Alyssa M Picchini; Eliot R Dow; Guang Chen; Husseini K Manji
Generation and behavioral characterization of beta-catenin forebrain-specific conditional knock-out mice.
Behavioural brain research 2008;189(1):117-25.
2008: Carlos A Zarate; Husseini K Manji
Bipolar disorder: candidate drug targets.
The Mount Sinai journal of medicine, New York 2008;75(3):226-47.
2008: Gerard Sanacora; Carlos A Zarate; John H Krystal; Husseini K Manji
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders.
Nature reviews. Drug discovery 2008;7(5):426-37.
2008: Carlos A Zarate; Husseini K Manji
The role of AMPA receptor modulation in the treatment of neuropsychiatric diseases.
Experimental neurology 2008;211(1):7-10.
2008: John H Krystal; Cameron S Carter; Daniel Geschwind; Husseini K Manji; John March; Eric J Nestler; Jon K Zubieta; Dennis S Charney; David Goldman; Raquel E Gur; Jeffrey A Lieberman; Peter Roy-Byrne; David Rubinow; Stewart A Anderson; Samuel Barondes; Karen F Berman; James Blair; David L Braff; E Sherwood Brown; Joseph Calabrese; William A Carlezon; Edwin H Cook; Richard Davidson; Michael Davis; Robert Desimone; Wayne C Drevets; Ronald S Duman; Susan M Essock; Stephen Faraone; Robert Freedman; Karl J Friston; Joel Gelernter; Barbara Geller; Michael Gill; Elizabeth Gould; Anthony A Grace; Christian Grillon; Ralitza Gueorguieva; Ahmad R Hariri; Robert B Innis; Edward G Jones; Joel E Kleinman; George F Koob; Andrew D Krystal; Ellen Leibenluft; Douglas F Levinson; Pat Levitt; David A Lewis; Israel Liberzon; Barbara K Lipska; Stephen R Marder; Athina Markou; Graeme F Mason; Christopher J McDougle; Bruce McEwen; Francis McMajon; Michael J Meaney; Herbert Y Meltzer; Kathleen Ries Merikangas; Andreas Meyer-Lindenberg; Károly Mirnics; Lisa M Monteggia; Alexander Neumeister; Charles P O'Brien; Michael J Owen; Daniel S Pine; Judy Rapoport; Scott L Rauch; Trevor W Robbins; Jerrold F Rosenbaum; David R Rosenberg; Christopher A Ross; john rush; Harold A Sackeim; Gerard Sanacora; Alan F Schatzberg; Yavin Shaham; Larry J Siever; Trey Sunderland; Laurence H Tecott; Michael E Thase; Richard D Todd; Myrna M Weissman; Rachel Yehuda; Takeo Yoshikawa; Elizabeth A Young; R McCandless
It is time to take a stand for medical research and against terrorism targeting medical scientists.
Biological psychiatry 2008;63(8):725-7.
2008: Lisa A Catapano; Husseini K Manji
Kinases as drug targets in the treatment of bipolar disorder.
Drug discovery today 2008;13(7-8):295-302.
2008: Todd D Gould; Kelley C O'Donnell; Eliot R Dow; Jing Du; Guang Chen; Husseini K Manji
Involvement of AMPA receptors in the antidepressant-like effects of lithium in the mouse tail suspension test and forced swim test.
Neuropharmacology 2008;54(3):577-87.
2008: Sungho Maeng; Carlos A Zarate; Jing Du; Robert Schloesser; Joseph McCammon; Guang Chen; Husseini K Manji
Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors.
Biological psychiatry 2008;63(4):349-52.
2008: Jing Du; Thomas K Creson; Long-Jun Wu; Ming Ren; Neil A Gray; Cynthia Falke; Yanling Wei; Yun Wang; Rayah Blumenthal; Rodrigo Machado-Vieira; Peixiong Yuan; Guang Chen; Min Zhuo; Husseini K Manji
The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(1):68-79.
2008: Andrew Newberg; Lisa A Catapano; Carlos A Zarate; Husseini K Manji
Neurobiology of bipolar disorder.
Expert review of neurotherapeutics 2008;8(1):93-110.
2008: Robert Schloesser; Jian Huang; Peter S Klein; Husseini K Manji
Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(1):110-33.
2007: Dara M Cannon; Masanori Ichise; Denise Rollis; Jacqueline M Klaver; Shilpa K Gandhi; Dennis S Charney; Husseini K Manji; Wayne C Drevets
Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder.
Biological psychiatry 2007;62(8):870-7.
2007: Gonzalo Laje; Silvia Paddock; Husseini K Manji; A John Rush; Alexander F Wilson; Dennis Charney; Francis McMajon
Genetic markers of suicidal ideation emerging during citalopram treatment of major depression.
The American journal of psychiatry 2007;164(10):1530-8.
2007: Todd D Gould; Haim Einat; Kelley C O'Donnell; Alyssa M Picchini; Robert Schloesser; Husseini K Manji
Beta-catenin overexpression in the mouse brain phenocopies lithium-sensitive behaviors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(10):2173-83.
2007: Carlos A Zarate; Jaskaran B Singh; Paul J Carlson; Jorge A Quiroz; Libby Jolkovsky; David Luckenbaugh; Husseini K Manji
Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study.
Bipolar disorders 2007;9(6):561-70.
2007: Keri Martinowich; Husseini K Manji; Bai Lu
New insights into BDNF function in depression and anxiety.
Nature neuroscience 2007;10(9):1089-93.
2007: Mitchel A Kling; Salvatore Alesci; Gyorgy Csako; Rene Costello; David Luckenbaugh; Omer Bonne; Roman Duncko; Wayne C Drevets; Husseini K Manji; Dennis S Charney; Philip W Gold; Alexander Neumeister
Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A.
Biological psychiatry 2007;62(4):309-13.
2007: Silvia Paddock; Gonzalo Laje; Dennis Charney; A John Rush; Alexander F Wilson; Alexa J M Sorant; Robert Henry Lipsky; Stephen R Wisniewski; Husseini K Manji; Francis McMajon
Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort.
The American journal of psychiatry 2007;164(8):1181-8.
2007: Xian-Zhang Hu; A John Rush; Dennis Charney; Alexander F Wilson; Alexa J M Sorant; George J Papanicolaou; Maurizio Fava; Madhukar H Trivedi; Stephen R Wisniewski; Gonzalo Laje; Silvia Paddock; Francis McMajon; Husseini K Manji; Robert Henry Lipsky
Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression.
Archives of general psychiatry 2007;64(7):783-92.
2007: De-Maw Chuang; Husseini K Manji
In search of the Holy Grail for the treatment of neurodegenerative disorders: has a simple cation been overlooked?
Biological psychiatry 2007;62(1):4-6.
2007: Todd D Gould; Eliot R Dow; Kelley C O'Donnell; Guang Chen; Husseini K Manji
Targeting signal transduction pathways in the treatment of mood disorders: recent insights into the relevance of the Wnt pathway.
CNS & neurological disorders drug targets 2007;6(3):193-204.
2007: Todd D Gould; Kelley C O'Donnell; Alyssa M Picchini; Husseini K Manji
Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(6):1321-33.
2007: Lisa A Catapano; Husseini K Manji
G protein-coupled receptors in major psychiatric disorders.
Biochimica et biophysica acta 2007;1768(4):976-93.
2007: Jing Du; Katsuji Suzuki; Yanling Wei; Yun Wang; Rayah Blumenthal; Zheng Chen; Cynthia Falke; Carlos A Zarate; Husseini K Manji
The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(4):793-802.
2007: Linda Mah; Carlos A Zarate; Jaskaran Singh; Yu-Fei Duan; David Luckenbaugh; Husseini K Manji; Wayne C Drevets
Regional cerebral glucose metabolic abnormalities in bipolar II depression.
Biological psychiatry 2007;61(6):765-75.
2007: Yves Agid; György Buzsáki; David M Diamond; Richard S J Frackowiak; Jay Giedd; Jean-Antoine Girault; Anthony Grace; Jeremy J Lambert; Husseini K Manji; Helen S Mayberg; Maurizio Popoli; Alain Prochiantz; Gal Richter-Levin; Peter Somogyi; Michael Spedding; Per Svenningsson; Daniel Weinberger
How can drug discovery for psychiatric disorders be improved?
Nature reviews. Drug discovery 2007;6(3):189-201.
2007: Neda F Gould; M Kathleen Holmes; Bryan D Fantie; David Luckenbaugh; Daniel S Pine; Todd D Gould; Neil Burgess; Husseini K Manji; Carlos A Zarate
Performance on a virtual reality spatial memory navigation task in depressed patients.
The American journal of psychiatry 2007;164(3):516-9.
2007: Galit Shaltiel; Guang Chen; Husseini K Manji
Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder.
Current opinion in pharmacology 2007;7(1):22-6.
2007: Haim Einat; Peixiong Yuan; Steven Szabo; Samriti Dogra; Husseini K Manji
Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder.
Neuropsychobiology 2007;55(3-4):123-31.
2007: Robert Schloesser; Guang Chen; Husseini K Manji
Neurogenesis and neuroenhancement in the pathophysiology and treatment of bipolar disorder.
International review of neurobiology 2007;77():143-78.
2006: Todd D Gould; Alyssa M Picchini; Haim Einat; Husseini K Manji
Targeting glycogen synthase kinase-3 in the CNS: implications for the development of new treatments for mood disorders.
Current drug targets 2006;7(11):1399-409.
2006: Andrew H Miller; Husseini K Manji
On redefining the role of the immune system in psychiatric disease.
Biological psychiatry 2006;60(8):796-8.
2006: Carlos A Zarate; Jaskaran B Singh; Paul J Carlson; Nancy E Brutsche; Rezvan Ameli; David Luckenbaugh; Dennis S Charney; Husseini K Manji
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Archives of general psychiatry 2006;63(8):856-64.
2006: Dara M Cannon; Masanori Ichise; Stephen J Fromm; Allison Nugent; Denise Rollis; Shilpa K Gandhi; Jacqueline M Klaver; Dennis S Charney; Husseini K Manji; Wayne C Drevets
Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography.
Biological psychiatry 2006;60(3):207-17.
2006: Gregor Hasler; Wayne C Drevets; Todd D Gould; Irving GOTTESMAN; Husseini K Manji
Toward constructing an endophenotype strategy for bipolar disorders.
Biological psychiatry 2006;60(2):93-105.
2006: Haim Einat; Husseini K Manji
Cellular plasticity cascades: genes-to-behavior pathways in animal models of bipolar disorder.
Biological psychiatry 2006;59(12):1160-71.
2006: Carlos A Zarate; Jaskaran Singh; Husseini K Manji
Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder.
Biological psychiatry 2006;59(11):1006-20.
2006: Rulun Zhou; Carlos A Zarate; Husseini K Manji
Identification of molecular mechanisms underlying mood stabilization through genome-wide gene expression profiling.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2006;9(3):263-6.
2006: Francis McMajon; Silvia Buervenich; Dennis Charney; Robert Henry Lipsky; A John Rush; Alexander F Wilson; Alexa J M Sorant; George J Papanicolaou; Gonzalo Laje; Maurizio Fava; Madhukar H Trivedi; Stephen R Wisniewski; Husseini K Manji
Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.
American journal of human genetics 2006;78(5):804-14.
2006: Guang Chen; Husseini K Manji
The extracellular signal-regulated kinase pathway: an emerging promising target for mood stabilizers.
Current opinion in psychiatry 2006;19(3):313-23.
2006: Salvatore Alesci; Michelle Rodak; Ioannis Ilias; Rulun Zhou; Husseini K Manji
The genomics of mood disorders.
Progress in brain research 2006;158():129-39.
2006: Paul J Carlson; Jaskaran B Singh; Carlos A Zarate; Wayne C Drevets; Husseini K Manji
Neural circuitry and neuroplasticity in mood disorders: insights for novel therapeutic targets.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2006;3(1):22-41.
2006: Carlos A Zarate; Jaskaran B Singh; Jorge A Quiroz; Georgette De Jesus; Kirk K Denicoff; David Luckenbaugh; Husseini K Manji; Dennis S Charney
A double-blind, placebo-controlled study of memantine in the treatment of major depression.
The American journal of psychiatry 2006;163(1):153-5.
2005: Haim Einat; Peixiong Yuan; Husseini K Manji
Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders.
Behavioural brain research 2005;165(2):172-80.
2005: Rosilla F Bachmann; Robert Schloesser; Todd D Gould; Husseini K Manji
Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics.
Molecular neurobiology 2005;32(2):173-202.
2005: Todd D Gould; Husseini K Manji
Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(7):1223-37.
2005: Rulun Zhou; Neil A Gray; Peixiong Yuan; Xiaoxia Li; Jingshan Chen; Guang Chen; Patricia Damschroder-Williams; Jing Du; Lei Zhang; Husseini K Manji
The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(18):4493-502.
2005: Alexander Neumeister; Peixiong Yuan; Theresa A Young; Omer Bonne; David Luckenbaugh; Dennis S Charney; Husseini K Manji
Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjects.
The American journal of psychiatry 2005;162(4):805-7.
2005: Alexander Neumeister; Dennis S Charney; Inna Belfer; Marilla Geraci; Courtney Holmes; Yehonatan Sharabi; Tanya Alim; Omer Bonne; David Luckenbaugh; Husseini K Manji; David Goldman; David S Goldstein
Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans.
Pharmacogenetics and genomics 2005;15(3):143-9.
2005: Carlos A Zarate; Jorge A Quiroz; Jaskaran B Singh; Kirk D Denicoff; Georgette De Jesus; David Luckenbaugh; Dennis S Charney; Husseini K Manji
An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression.
Biological psychiatry 2005;57(4):430-2.
2005: Todd D Gould; Husseini K Manji
DARPP-32: A molecular switch at the nexus of reward pathway plasticity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(2):253-4.
2004: Todd D Gould; Haim Einat; Ratan Bhat; Husseini K Manji
AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2004;7(4):387-90.
2004: Shari G Birnbaum; PX Yuan; Min Wang; Susheel Vijayraghavan; A K Bloom; D J Davis; K T Gobeske; J D Sweatt; Husseini K Manji; Amy F T Arnsten
Protein kinase C overactivity impairs prefrontal cortical regulation of working memory.
Science (New York, N.Y.) 2004;306(5697):882-4.
2004: Jorge A Quiroz; Todd D Gould; Husseini K Manji
Molecular effects of lithium.
Molecular interventions 2004;4(5):259-72.
2004: Gregor Hasler; Wayne C Drevets; Husseini K Manji; Dennis S Charney
Discovering endophenotypes for major depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(10):1765-81.
2004: Jing Du; Steven Szabo; Neil A Gray; Husseini K Manji
Focus on CaMKII: a molecular switch in the pathophysiology and treatment of mood and anxiety disorders.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2004;7(3):243-8.
2004: Jing Du; Jorge Quiroz; Peixiong Yuan; Carlos Zarate; Husseini K Manji
Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses.
Neuron glia biology 2004;1(3):231-43.
2004: Jorge A Quiroz; Jaskaran Singh; Todd D Gould; Kirk D Denicoff; Carlos A Zarate; Husseini K Manji
Emerging experimental therapeutics for bipolar disorder: clues from the molecular pathophysiology.
Molecular psychiatry 2004;9(8):756-76.
2004: Todd D Gould; Jorge A Quiroz; Jaskaran Singh; Carlos A Zarate; Husseini K Manji
Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers.
Molecular psychiatry 2004;9(8):734-55.
2004: Yanlei Hao; Thomas Creson; Lei Zhang; Pipeng Li; Fu Du; Peixiong Yuan; Todd D Gould; Husseini K Manji; Guang Chen
Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(29):6590-9.
2004: Jing Du; Neil A Gray; Cynthia A Falke; Wenxin Chen; Peixiong Yuan; Steven Szabo; Haim Einat; Husseini K Manji
Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(29):6578-89.
2004: Carlos A Zarate; Jennifer L Payne; Jaskaran Singh; Jorge A Quiroz; David Luckenbaugh; Kirk D Denicoff; Dennis S Charney; Husseini K Manji
Pramipexole for bipolar II depression: a placebo-controlled proof of concept study.
Biological psychiatry 2004;56(1):54-60.
2004: Jing Du; Neil A Gray; Jorge A Quiroz; Steven Szabo; Carlos A Zarate; Husseini K Manji
Regulation of cellular plasticity and resilience by mood stabilizers: the role of AMPA receptor trafficking.
Dialogues in clinical neuroscience 2004;6(2):143-55.
2004: Dennis S Charney; Georgette Dejesus; Husseini K Manji
Cellular plasticity and resilience and the pathophysiology of severe mood disorders.
Dialogues in clinical neuroscience 2004;6(2):217-25.
2004: Haim Einat; Guang Chen; Husseini K Manji
[Possible involvement of protein kinase C in the pathophysiology and treatment of bipolar disorder].
Harefuah 2004;143(6):420-5, 462.
2004: Todd D Gould; Husseini K Manji
The molecular medicine revolution and psychiatry: bridging the gap between basic neuroscience research and clinical psychiatry.
The Journal of clinical psychiatry 2004;65(5):598-604.
2004: Ayşegül Ozerdem; Mark E Schmidt; Husseini K Manji; Robert C Risinger; William Z Potter
Chronic lithium administration enhances noradrenergic responses to intravenous administration of the alpha2 antagonist idazoxan in healthy volunteers.
Journal of clinical psychopharmacology 2004;24(2):150-4.
2004: Dennis S Charney; Husseini K Manji
Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention.
Science's STKE : signal transduction knowledge environment 2004;2004(225):re5.
2004: Todd D Gould; Carlos A Zarate; Husseini K Manji
Glycogen synthase kinase-3: a target for novel bipolar disorder treatments.
The Journal of clinical psychiatry 2004;65(1):10-21.
2004: Carlos A Zarate; Jennifer L Payne; Jorge A Quiroz; Jonathan Sporn; Kirk K Denicoff; David Luckenbaugh; Dennis S Charney; Husseini K Manji
An open-label trial of riluzole in patients with treatment-resistant major depression.
The American journal of psychiatry 2004;161(1):171-4.
2004: Todd D Gould; Guang Chen; Husseini K Manji
In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(1):32-8.
2003: Husseini K Manji; Irving GOTTESMAN; Todd D Gould
Signal transduction and genes-to-behaviors pathways in psychiatric diseases.
Science's STKE : signal transduction knowledge environment 2003;2003(207):pe49.
2003: Neil A Gray; Jing Du; Cynthia Falke; Peixiong Yuan; Husseini K Manji
Lithium regulates total and synaptic expression of the AMPA glutamate receptor GluR2 in vitro and in vivo.
Annals of the New York Academy of Sciences 2003;1003():402-4.
2003: Jing Du; Neil A Gray; Cynthia Falke; Peixiong Yuan; Steven Szabo; Husseini K Manji
Structurally dissimilar antimanic agents modulate synaptic plasticity by regulating AMPA glutamate receptor subunit GluR1 synaptic expression.
Annals of the New York Academy of Sciences 2003;1003():378-80.
2003: Carlos A Zarate; Jing Du; Jorge A Quiroz; Neil A Gray; Kirk D Denicoff; Jaskaran Singh; Dennis S Charney; Husseini K Manji
Regulation of cellular plasticity cascades in the pathophysiology and treatment of mood disorders: role of the glutamatergic system.
Annals of the New York Academy of Sciences 2003;1003():273-91.
2003: Husseini K Manji; Jorge A Quiroz; Jennifer L Payne; Jaskaran Singh; Barbara P Lopes; Jenilee S Viegas; Carlos A Zarate
The underlying neurobiology of bipolar disorder.
World psychiatry : official journal of the World Psychiatric Association (WPA) 2003;2(3):136-46.
2003: Terence A Ketter; Husseini K Manji; Robert M Post
Potential mechanisms of action of lamotrigine in the treatment of bipolar disorders.
Journal of clinical psychopharmacology 2003;23(5):484-95.
2003: Haim Einat; Husseini K Manji; Todd D Gould; Jing Du; Guang Chen
Possible involvement of the ERK signaling cascade in bipolar disorder: behavioral leads from the study of mutant mice.
Drug news & perspectives 2003;16(7):453-63.
2003: Haim Einat; Peixiong Yuan; Todd D Gould; Jianling Li; JianHua Du; Lei Zhang; Husseini K Manji; Guang Chen
The role of the extracellular signal-regulated kinase signaling pathway in mood modulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(19):7311-6.
2003: Danielle M Dick; Tatiana Foroud; Leah Flury; Elizabeth S Bowman; Marvin J Miller; N Leela Rau; P Ryan Moe; Nalini Samavedy; Rif El-Mallakh; Husseini K Manji; Debra A Glitz; Eric T Meyer; Carrie Smiley; Rhoda Hahn; Clifford Widmark; Rebecca McKinney; Laura Sutton; Christos Ballas; Dorothy Grice; Wade Berrettini; William Byerley; William Coryell; J. Raymond DePaulo; Dean F MacKinnon; Elliot S Gershon; John R Kelsoe; Francis McMajon; Melvin G McInnis; Dennis L Murphy; Theodore Reich; William Scheftner; John I Nurnberger
Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative.
American journal of human genetics 2003;73(1):107-14.
2003: Todd D Gould; Neil A Gray; Husseini K Manji
Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice.
Pharmacological research : the official journal of the Italian Pharmacological Society 2003;48(1):49-53.
2003: Jianling Li; Todd D Gould; Peixiong Yuan; Husseini K Manji; Guang Chen
Post-mortem interval effects on the phosphorylation of signaling proteins.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(6):1017-25.
2003: Husseini K Manji; Jorge A Quiroz; Jonathan Sporn; Jennifer L Payne; Kirk D Denicoff; Neil A Gray; Carlos A Zarate; Dennis S Charney
Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression.
Biological psychiatry 2003;53(8):707-42.
2003: Haim Einat; Husseini K Manji; Robert H Belmaker
New approaches to modeling bipolar disorder.
Psychopharmacology bulletin 2003;37(1):47-63.
2003: Neil A Gray; Rulun Zhou; Jing Du; Gregory Moore; Husseini K Manji
The use of mood stabilizers as plasticity enhancers in the treatment of neuropsychiatric disorders.
The Journal of clinical psychiatry 2003;64 Suppl 5():3-17.
2003: Xizhong Huang; Da-Yu Wu; Guang Chen; Husseini K Manji; Dong Feng Chen
Support of retinal ganglion cell survival and axon regeneration by lithium through a Bcl-2-dependent mechanism.
Investigative ophthalmology & visual science 2003;44(1):347-54.
2003: Husseini K Manji
Depression, III: treatments.
The American journal of psychiatry 2003;160(1):24.
2002: Jennifer L Payne; Jorge A Quiroz; Carlos A Zarate; Husseini K Manji
Timing is everything: does the robust upregulation of noradrenergically regulated plasticity genes underlie the rapid antidepressant effects of sleep deprivation?
Biological psychiatry 2002;52(10):921-6.
2002: Debra Glitz; Husseini K Manji; Gregory Moore
Mood disorders: treatment-induced changes in brain neurochemistry and structure.
Seminars in clinical neuropsychiatry 2002;7(4):269-80.
2002: Todd D Gould; Husseini K Manji
The Wnt signaling pathway in bipolar disorder.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2002;8(5):497-511.
2002: Eric J Nestler; Elizabeth Gould; Husseini K Manji; Maja Buncan; Ronald S Duman; Howard K Greshenfeld; Ren Hen; Susan Koester; Israel Lederhendler; Michael Meaney; Trevor W Robbins; Lois Winsky; Steve Zalcman
Preclinical models: status of basic research in depression.
Biological psychiatry 2002;52(6):503-28.
2002: Todd D Gould; Husseini K Manji
Signaling networks in the pathophysiology and treatment of mood disorders.
Journal of psychosomatic research 2002;53(2):687-97.
2002: Joseph T Coyle; Husseini K Manji
Getting balance: drugs for bipolar disorder share target.
Nature medicine 2002;8(6):557-8.
2002: RH Lenox; Todd D Gould; Husseini K Manji
Endophenotypes in bipolar disorder.
American journal of medical genetics 2002;114(4):391-406.
2002: Jorge A Quiroz; Husseini K Manji
Enhancing synaptic plasticity and cellular resilience to develop novel, improved treatments for mood disorders.
Dialogues in clinical neuroscience 2002;4(1):73-92.
2002: Carlos A Zarate; Jorge Quiroz; Jennifer L Payne; Husseini K Manji
Modulators of the glutamatergic system: implications for the development of improved therapeutics in mood disorders.
Psychopharmacology bulletin 2002;36(4):35-83.
2002: Brian H Harvey; Catharina L Meyer; Vincent S Gallichio; Husseini K Manji
Lithium salts in AIDS and AIDS-related dementia.
Psychopharmacology bulletin 2002;36(1):5-26.
2002: Husseini K Manji; Guang Chen
PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers.
Molecular psychiatry 2002;7 Suppl 1():S46-56.
2002: Husseini K Manji; C A Zarate
Molecular and cellular mechanisms underlying mood stabilization in bipolar disorder: implications for the development of improved therapeutics.
Molecular psychiatry 2002;7 Suppl 1():S1-7.
2001: PX Yuan; LD Huang; YM Jiang; J Silvio Gutkind; Husseini K Manji; Guang Chen
The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth.
The Journal of biological chemistry 2001;276(34):31674-83.
2001: Mark Hyman Rapaport; Husseini K Manji
The effects of lithium on ex vivo cytokine production.
Biological psychiatry 2001;50(3):217-24.
2001: Husseini K Manji; Gregory Moore; Guang Chen
Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers.
The British journal of psychiatry. Supplement 2001;41():s107-19.
2001: Husseini K Manji; W C Drevets; D S Charney
The cellular neurobiology of depression.
Nature medicine 2001;7(5):541-7.
2001: Husseini K Manji; R S Duman
Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics.
Psychopharmacology bulletin 2001;35(2):5-49.
2000: Husseini K Manji; Guang Chen
Post-receptor signaling pathways in the pathophysiology and treatment of mood disorders.
Current psychiatry reports 2000;2(6):479-89.
2000: Husseini K Manji; Gregory Moore; G Rajkowska; Guang Chen
Neuroplasticity and cellular resilience in mood disorders.
Molecular psychiatry 2000;5(6):578-93.
2000: Husseini K Manji; Gregory Moore; Guang Chen
Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic-depressive illness.
Biological psychiatry 2000;48(8):740-54.
2000: Gregory Moore; JM Bebchuk; Ian B Wilds; Guang Chen; Husseini K Manji; H K Menji
Lithium-induced increase in human brain grey matter.
Lancet 2000;356(9237):1241-2.
2000: Guang Chen; G Rajkowska; F Du; Navid Seraji-Bozorgzad; Husseini K Manji
Enhancement of hippocampal neurogenesis by lithium.
Journal of neurochemistry 2000;75(4):1729-34.
2000: Ognian C Ikonomov; Theodor Petrov; K Soden; Assia Shisheva; Husseini K Manji
Lithium treatment in ovo: effects on embryonic heart rate, natural death of ciliary ganglion neurons, and brain expression of a highly conserved chicken homolog of human MTG8/ETO.
Brain research. Developmental brain research 2000;123(1):13-24.
2000: Husseini K Manji; RH Lenox
Signaling: cellular insights into the pathophysiology of bipolar disorder.
Biological psychiatry 2000;48(6):518-30.
2000: Guang Chen; M I Masana; Husseini K Manji
Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo.
Bipolar disorders 2000;2(3 Pt 2):217-36.
2000: Jair C Soares; Guang Chen; CS Dippold; Kelly Forster Wells; Ellen Frank; David J Kupfer; Husseini K Manji; ALAN MALLINGER
Concurrent measures of protein kinase C and phosphoinositides in lithium-treated bipolar patients and healthy individuals: a preliminary study.
Psychiatry research 2000;95(2):109-18.
2000: Gregory Moore; JM Bebchuk; KA Hasanat; Guang Chen; Navid Seraji-Bozorgzad; Ian B Wilds; Michael W Faulk; S Koch; Debra Glitz; Libby Jolkovsky; Husseini K Manji
Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects?
Biological psychiatry 2000;48(1):1-8.
2000: Husseini K Manji; RH Lenox
The nature of bipolar disorder.
The Journal of clinical psychiatry 2000;61 Supp 13():42-57.
2000: Husseini K Manji; Gregory Moore; Guang Chen
Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness.
The Journal of clinical psychiatry 2000;61 Suppl 9():82-96.
2000: JM Bebchuk; Cynthia L Arfken; S Dolan-Manji; J Murphy; KA Hasanat; Husseini K Manji
A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania.
Archives of general psychiatry 2000;57(1):95-7.
1999: Husseini K Manji; R McNamara; Guang Chen; RH Lenox
Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illness.
The Australian and New Zealand journal of psychiatry 1999;33 Suppl():S65-83.
1999: Gregory Moore; JM Bebchuk; J K Parrish; Michael W Faulk; Cynthia L Arfken; J Strahl-Bevacqua; Husseini K Manji
Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness.
The American journal of psychiatry 1999;156(12):1902-8.
1999: Peixiong Yuan; Guang Chen; Husseini K Manji
Lithium activates the c-Jun NH2-terminal kinases in vitro and in the CNS in vivo.
Journal of neurochemistry 1999;73(6):2299-309.
1999: Husseini K Manji; RH Lenox
Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness.
Biological psychiatry 1999;46(10):1328-51.
1999: Ognian C Ikonomov; Husseini K Manji
Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challenge.
The American journal of psychiatry 1999;156(10):1506-14.
1999: Husseini K Manji; Gregory Moore; Guang Chen
Lithium at 50: have the neuroprotective effects of this unique cation been overlooked?
Biological psychiatry 1999;46(7):929-40.
1999: Guang Chen; KA Hasanat; JM Bebchuk; Gregory Moore; Debra Glitz; Husseini K Manji
Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants.
Psychosomatic medicine 1999;61(5):599-617.
1999: Guang Chen; LD Huang; YM Jiang; Husseini K Manji
The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3.
Journal of neurochemistry 1999;72(3):1327-30.
1999: Guang Chen; W Z Zeng; PX Yuan; LD Huang; YM Jiang; Z H Zhao; Husseini K Manji
The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS.
Journal of neurochemistry 1999;72(2):879-82.
1999: Guang Chen; PX Yuan; YM Jiang; LD Huang; Husseini K Manji
Valproate robustly enhances AP-1 mediated gene expression.
Brain research. Molecular brain research 1999;64(1):52-8.
1999: Husseini K Manji; JM Bebchuk; Gregory Moore; Debra Glitz; KA Hasanat; Guang Chen
Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implications.
The Journal of clinical psychiatry 1999;60 Suppl 2():27-39; discussion 40-1, 113-6.
1998: Husseini K Manji; RH Lenox
Lithium: a molecular transducer of mood-stabilization in the treatment of bipolar disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;19(3):161-6.
1998: PX Yuan; Guang Chen; LD Huang; Husseini K Manji
Lithium stimulates gene expression through the AP-1 transcription factor pathway.
Brain research. Molecular brain research 1998;58(1-2):225-30.
1998: Guang Chen; PX Yuan; YM Jiang; LD Huang; Husseini K Manji
Lithium increases tyrosine hydroxylase levels both in vivo and in vitro.
Journal of neurochemistry 1998;70(4):1768-71.
1998: RH Lenox; Robert K McNamara; Roger L Papke; Husseini K Manji
Neurobiology of lithium: an update.
The Journal of clinical psychiatry 1998;59 Suppl 6():37-47.
1997: N Ozaki; Husseini K Manji; V Lubierman; S J Lu; J Lappalainen; Norman Rosenthal; David Goldman
A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization.
Journal of neurochemistry 1997;68(5):2186-93.
1997: Guang Chen; Peixiong Yuan; D B Hawver; W Z Potter; Husseini K Manji
Increase in AP-1 transcription factor DNA binding activity by valproic acid.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1997;16(3):238-45.
1997: P B Mitchell; Husseini K Manji; Guang Chen; Libby Jolkovsky; E Smith-Jackson; Kirk D Denicoff; M Schmidt; W Z Potter
High levels of Gs alpha in platelets of euthymic patients with bipolar affective disorder.
The American journal of psychiatry 1997;154(2):218-23.
1997: Husseini K Manji; Guang Chen; W Potter; Thomas R Kosten
Guanine nucleotide binding proteins in opioid-dependent patients.
Biological psychiatry 1997;41(2):130-4.
1997: A Ram; F Guedj; A Cravchik; L Weinstein; Q Cao; Judith A Badner; LR Goldin; N Grisaru; Husseini K Manji; R H Belmaker; Elliot S Gershon; Pablo V Gejman
No abnormality in the gene for the G protein stimulatory alpha subunit in patients with bipolar disorder.
Archives of general psychiatry 1997;54(1):44-8.
1996: Guang Chen; B Pan; D B Hawver; Clinton Wright; William Z Potter; Husseini K Manji
Attenuation of cyclic AMP production by carbamazepine.
Journal of neurochemistry 1996;67(5):2079-86.
1996: Husseini K Manji; Y Bersudsky; Guang Chen; R H Belmaker; William Z Potter
Modulation of protein kinase C isozymes and substrates by lithium: the role of myo-inositol.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1996;15(4):370-81.
1996: Guang Chen; Husseini K Manji; Clinton Wright; D B Hawver; William Z Potter
Effects of valproic acid on beta-adrenergic receptors, G-proteins, and adenylyl cyclase in rat C6 glioma cells.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1996;15(3):271-80.
1996: Murray B Stein; Guang Chen; W Z Potter; Husseini K Manji
G-protein level quantification in platelets and leukocytes from patients with panic disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1996;15(2):180-6.
1996: Husseini K Manji; Guang Chen; J K Hsiao; E D Risby; M I Masana; William Z Potter
Regulation of signal transduction pathways by mood-stabilizing agents: implications for the delayed onset of therapeutic efficacy.
The Journal of clinical psychiatry 1996;57 Suppl 13():34-46; discussion 47-8.
1995: K Suyama; K Saito; Guang Chen; B S Pan; Husseini K Manji; William Z Potter
Alterations in cyclic AMP generation and G protein subunits following transient ischemia in gerbil hippocampus.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1995;15(5):877-85.
1995: Husseini K Manji; William Z Potter; RH Lenox
Signal transduction pathways. Molecular targets for lithium's actions.
Archives of general psychiatry 1995;52(7):531-43.
1995: Husseini K Manji; Guang Chen; H Shimon; J K Hsiao; William Z Potter; R H Belmaker
Guanine nucleotide-binding proteins in bipolar affective disorder. Effects of long-term lithium treatment.
Archives of general psychiatry 1995;52(2):135-44.
1995: I W Chung; Y S Kim; J S Ahn; H S Lee; Guang Chen; Husseini K Manji; W Z Potter; DAVID PICKAR
Pharmacologic profile of natural products used to treat psychotic illnesses.
Psychopharmacology bulletin 1995;31(1):139-45.
1995: JOSE BITRAN; Husseini K Manji; William Z Potter; F Gusovsky
Down-regulation of PKC alpha by lithium in vitro.
Psychopharmacology bulletin 1995;31(2):449-52.
1994: Guang Chen; Husseini K Manji; D B Hawver; Clinton Wright; William Z Potter
Chronic sodium valproate selectively decreases protein kinase C alpha and epsilon in vitro.
Journal of neurochemistry 1994;63(6):2361-4.
1994: Mark Hyman Rapaport; M E Schmidt; R Risinger; Husseini K Manji
The effects of prolonged lithium exposure on the immune system of normal control subjects: serial serum soluble interleukin-2 receptor and antithyroid antibody measurements.
Biological psychiatry 1994;35(10):761-6.
1994: K Suyama; K H Dykstra; M I Masana; Husseini K Manji; William Z Potter
In vivo evidence that nonneuronal beta-adrenoceptors as well as dopamine receptors contribute to cyclic AMP efflux in rat striatum.
Journal of neurochemistry 1994;62(5):1734-40.
1994: William Z Potter; Husseini K Manji
Catecholamines in depression: an update.
Clinical chemistry 1994;40(2):279-87.
1994: M V Rudorfer; Husseini K Manji; William Z Potter
Comparative tolerability profiles of the newer versus older antidepressants.
Drug safety : an international journal of medical toxicology and drug experience 1994;10(1):18-46.
1994: Husseini K Manji; RH Lenox
Long-term action of lithium: a role for transcriptional and posttranscriptional factors regulated by protein kinase C.
Synapse (New York, N.Y.) 1994;16(1):11-28.
1993: Husseini K Manji; René Etcheberrigaray; Guang Chen; J L Olds
Lithium decreases membrane-associated protein kinase C in hippocampus: selectivity for the alpha isozyme.
Journal of neurochemistry 1993;61(6):2303-10.
1993: S E Molchan; Husseini K Manji; Guang Chen; L Dou; John Timothy Little; W Z Potter; Trey Sunderland
Effects of chronic lithium treatment on platelet PKC isozymes in Alzheimer's and elderly control subjects.
Neuroscience letters 1993;162(1-2):187-91.
1993: William Z Potter; Husseini K Manji
Are monoamine metabolites in cerebrospinal fluid worth measuring?
Archives of general psychiatry 1993;50(8):653-6.
1992: M V Rudorfer; Husseini K Manji; W Z Potter
ECT and delirium in Parkinson's disease.
The American journal of psychiatry 1992;149(12):1758-9; author reply 1759-60.
1992: Husseini K Manji; Guang Chen; JOSE BITRAN; F Gusovsky; William Z Potter
Idazoxan down-regulates beta-adrenoceptors on C6 glioma cells in vitro.
European journal of pharmacology 1992;227(3):275-82.
1992: Klaus-Peter Lesch; Husseini K Manji
Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain.
Biological psychiatry 1992;32(7):549-79.
1992: Husseini K Manji
G proteins: implications for psychiatry.
The American journal of psychiatry 1992;149(6):746-60.
1992: J K Hsiao; Husseini K Manji; Guang Chen; J A Bitran; E D Risby; William Z Potter
Lithium administration modulates platelet Gi in humans.
Life sciences 1992;50(3):227-33.
1992: R W Parks; D J Crockett; Husseini K Manji; W Ammann
Assessment of bromocriptine intervention for the treatment of frontal lobe syndrome: a case study.
The Journal of neuropsychiatry and clinical neurosciences 1992;4(1):109-11.
1992: M V Rudorfer; Husseini K Manji; William Z Potter
Monoaminergic actions of ECT.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():677A-678A.
1992: Husseini K Manji; E D Risby; J K Hsiao; Guang Chen; William Z Potter
Effects of lithium on signal transduction in humans.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():608A-609A.
1992: William Z Potter; Husseini K Manji; Karon Dawkins; F Grossman
Combined measures of noradrenergic output and receptor responsivity in depression.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():319A-320A.
1991: William Z Potter; M V Rudorfer; Husseini K Manji
The pharmacologic treatment of depression.
The New England journal of medicine 1991;325(9):633-42.
1991: M V Rudorfer; Husseini K Manji; W Z Potter
Bupropion, ECT, and dopaminergic overdrive.
The American journal of psychiatry 1991;148(8):1101-2.
1991: E D Risby; J K Hsiao; Husseini K Manji; J Bitran; F Moses; D F Zhou; William Z Potter
The mechanisms of action of lithium. II. Effects on adenylate cyclase activity and beta-adrenergic receptor binding in normal subjects.
Archives of general psychiatry 1991;48(6):513-24.
1991: Husseini K Manji; J K Hsiao; E D Risby; J Oliver; M V Rudorfer; William Z Potter
The mechanisms of action of lithium. I. Effects on serotoninergic and noradrenergic systems in normal subjects.
Archives of general psychiatry 1991;48(6):505-12.
1991: Husseini K Manji; Guang Chen; J A Bitran; F Gusovsky; William Z Potter
Chronic exposure of C6 glioma cells to desipramine desensitizes beta-adrenoceptors, but increases KL/KH ratio.
European journal of pharmacology 1991;206(2):159-62.
1991: Husseini K Manji; J A Bitran; M I Masana; Guang Chen; J K Hsiao; E D Risby; M V Rudorfer; William Z Potter
Signal transduction modulation by lithium: cell culture, cerebral microdialysis and human studies.
Psychopharmacology bulletin 1991;27(3):199-208.
1991: Husseini K Manji; Guang Chen; J A Bitran; William Z Potter
Down-regulation of beta receptors by desipramine in vitro involves PKC/phospholipase A2.
Psychopharmacology bulletin 1991;27(3):247-53.
1990: J A Bitran; William Z Potter; Husseini K Manji; F Gusovsky
Chronic Li+ attenuates agonist- and phorbol ester-mediated Na+/H+ antiporter activity in HL-60 cells.
European journal of pharmacology 1990;188(4-5):193-202.
1990: William Z Potter; Husseini K Manji
Antidepressants, metabolites, and apparent drug resistance.
Clinical neuropharmacology 1990;13 Suppl 1():S45-53.
1989: Athanasios P Zis; Husseini K Manji; Ronald Remick; B E Grant; C M Clark
Effect of the 5-HT2 antagonist ketanserin on the ECT-induced prolactin release.
Biological psychiatry 1989;26(1):102-6.
1987: Husseini K Manji; M Lander
Bromocriptine in neuroleptic resistance.
Biological psychiatry 1987;22(4):523-4.