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Belur Manjula

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K Ananda; Marcos Intaglietta; Belur N Manjula; Fantao Meng; Vivek N Acharya; Seetharama A Acharya
Packing density of the PEG-shell in PEG-albumins: PEGylation induced viscosity and COP are inverse correlate of packing density.
Dongxia Li; Tao Hu; Belur N Manjula; Seetharama A Acharya
Extension arm facilitated pegylation of alphaalpha-hemoglobin with modifications targeted exclusively to amino groups: functional and structural advantages of free Cys-93(beta) in the PEG-Hb adduct.
Fantao Meng; Belur N Manjula; Amy Tsai; Pedro Cabrales; Marcos Intaglietta; Paul K Smith; Muthuchidambaram Prabhakaran; Seetharama A Acharya
Hexa-thiocarbamoyl phenyl PEG5K Hb: vasoactivity and structure: influence of rigidity of the conjugation linkage on the PEGylation induced plasma expander-like solution properties of PEG-Hb adducts.

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All Publications

2012: K Ananda; Marcos Intaglietta; Belur N Manjula; Fantao Meng; Vivek N Acharya; Seetharama A Acharya
Packing density of the PEG-shell in PEG-albumins: PEGylation induced viscosity and COP are inverse correlate of packing density.
Artificial cells, blood substitutes, and immobilization biotechnology 2012;40(1-2):14-27.
2009: Dongxia Li; Tao Hu; Belur N Manjula; Seetharama A Acharya
Extension arm facilitated pegylation of alphaalpha-hemoglobin with modifications targeted exclusively to amino groups: functional and structural advantages of free Cys-93(beta) in the PEG-Hb adduct.
Bioconjugate chemistry 2009;20(11):2062-70.
2009: Fantao Meng; Belur N Manjula; Amy Tsai; Pedro Cabrales; Marcos Intaglietta; Paul K Smith; Muthuchidambaram Prabhakaran; Seetharama A Acharya
Hexa-thiocarbamoyl phenyl PEG5K Hb: vasoactivity and structure: influence of rigidity of the conjugation linkage on the PEGylation induced plasma expander-like solution properties of PEG-Hb adducts.
The protein journal 2009;28(5):199-212.
2009: Tao Hu; Dongxia Li; Belur N Manjula; Michael Brenowitz; Muthuchidambaram Prabhakaran; Seetharama A Acharya
PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin.
Biochemistry 2009;48(3):608-16.
2009: ranjit sahu; Parimala Nacharaju; Belur N Manjula; Seetharama A Acharya
Induced plasma expander-like properties as a function of PEG-chains on extension arm facilitated PEGylation of albumin: "mushroom to brush-like" conformational transition of the PEG-albumin conjugate.
Artificial cells, blood substitutes, and immobilization biotechnology 2009;37(6):245-56.
2008: Tao Hu; Dongxia Li; Belur N Manjula; Seetharama A Acharya
Autoxidation of the site-specifically PEGylated hemoglobins: role of the PEG chains and the sites of PEGylation in the autoxidation.
Biochemistry 2008;47(41):10981-90.
2008: Dongxia Li; Tao Hu; Belur N Manjula; Seetharama A Acharya
Non-conservative surface decoration of hemoglobin: influence of neutralization of positive charges at PEGylation sites on molecular and functional properties of PEGylated hemoglobin.
Biochimica et biophysica acta 2008;1784(10):1395-401.
2008: Fantao Meng; Belur N Manjula; Paul K Smith; Seetharama A Acharya
PEGylation of human serum albumin: reaction of PEG-phenyl-isothiocyanate with protein.
Bioconjugate chemistry 2008;19(7):1352-60.
2008: K Ananda; Parimala Nacharaju; Paul K Smith; Seetharama A Acharya; Belur N Manjula
Analysis of functionalization of methoxy-PEG as maleimide-PEG.
Analytical biochemistry 2008;374(2):231-42.
2007: Seetharama A Acharya; Vivek N Acharya; Nirmala Devi Kanika; Amy Tsai; Marcos Intaglietta; Belur N Manjula
Non-hypertensive tetraPEGylated canine haemoglobin: correlation between PEGylation, O2 affinity and tissue oxygenation.
The Biochemical journal 2007;405(3):503-11.
2007: Parimala Nacharaju; Joel Mitchel Friedman; Muthuchidambaram Prabhakaran; Seetharama A Acharya; Belur N Manjula
Combining the influence of two low O2 affinity-inducing chemical modifications of the central cavity of hemoglobin.
Biochemistry 2007;46(15):4554-64.
2007: Tao Hu; Belur N Manjula; Dongxia Li; Michael Brenowitz; Seetharama A Acharya
Influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated haemoglobin.
The Biochemical journal 2007;402(1):143-51.
2007: Parimala Nacharaju; Belur N Manjula; Seetharama A Acharya
Thiolation mediated pegylation platform to generate functional universal red blood cells.
Artificial cells, blood substitutes, and immobilization biotechnology 2007;35(1):107-18.
2007: Dongxia Li; Belur N Manjula; Nancy T Ho; Virgil Simplaceanu; Chien Ho; Seetharama A Acharya
Molecular aspects of the high oxygen affinity of non-hypertensive hexa pegylated hemoglobin, [(SP-PEG5K)(6)-Hb].
Artificial cells, blood substitutes, and immobilization biotechnology 2007;35(1):19-29.
2006: Sonati Srinivasulu; Krishnaveni Perumalsamy; Rajendra Upadhya; Belur N Manjula; Steven Feiring; Raouf Alami; Eric E Bouhassira; Mary E Fabry; Ronald L Nagel; Seetharama A Acharya
Pair-wise interactions of polymerization inhibitory contact site mutations of hemoglobin-S.
The protein journal 2006;25(7-8):503-16.
2006: Amy Tsai; Pedro Cabrales; Belur N Manjula; Seetharama A Acharya; Robert M Winslow; Marcos Intaglietta
Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers.
Blood 2006;108(10):3603-10.
2006: Dongxia Li; Belur N Manjula; Seetharama A Acharya
Extension arm facilitated PEGylation of hemoglobin: correlation of the properties with the extent of PEGylation.
The protein journal 2006;25(4):263-74.
2006: Muthuchidambaram Prabhakaran; Belur N Manjula; Seetharama A Acharya
Molecular modeling studies of surface decoration of hemoglobin by maleimide PEG.
Artificial cells, blood substitutes, and immobilization biotechnology 2006;34(4):381-93.
2006: Nanae Hangai-Hoger; Parimala Nacharaju; Belur N Manjula; Pedro Cabrales; Amy Tsai; Seetharama A Acharya; Marcos Intaglietta
Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia.
Critical care medicine 2006;34(1):108-17.
2005: Tao Hu; Muthuchidambaram Prabhakaran; Seetharama A Acharya; Belur N Manjula
Influence of the chemistry of conjugation of poly(ethylene glycol) to Hb on the oxygen-binding and solution properties of the PEG-Hb conjugate.
The Biochemical journal 2005;392(Pt 3):555-64.
2005: Pedro Cabrales; Parimala Nacharaju; Belur N Manjula; Amy Tsai; Seetharama A Acharya; Marcos Intaglietta
Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders.
Shock (Augusta, Ga.) 2005;24(1):66-73.
2005: Belur N Manjula; Amy Tsai; Marcos Intaglietta; Ching-Hsuan Tsai; Chien Ho; Paul K Smith; Krishnaveni Perumalsamy; Nirmala Devi Kanika; Joel Mitchel Friedman; Seetharama A Acharya
Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation: influence on hemoglobin structure and function.
The protein journal 2005;24(3):133-46.
2005: Parimala Nacharaju; Fouad N Boctor; Belur N Manjula; Seetharama A Acharya
Surface decoration of red blood cells with maleimidophenyl-polyethylene glycol facilitated by thiolation with iminothiolane: an approach to mask A, B, and D antigens to generate universal red blood cells.
Transfusion 2005;45(3):374-83.
2005: Seetharama A Acharya; Joel Mitchel Friedman; Belur N Manjula; Marcos Intaglietta; Amy Tsai; Robert M Winslow; Ashok Malavalli; Kim Vandegriff; Paul K Smith
Enhanced molecular volume of conservatively pegylated Hb: (SP-PEG5K)6-HbA is non-hypertensive.
Artificial cells, blood substitutes, and immobilization biotechnology 2005;33(3):239-55.
2004: Pedro Cabrales; Nirmala Devi Kanika; Belur N Manjula; Amy Tsai; Seetharama A Acharya; Marcos Intaglietta
Microvascular PO2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(beta) in hamster window chamber.
American journal of physiology. Heart and circulatory physiology 2004;287(4):H1609-17.
2004: Sonati Srinivasulu; Belur N Manjula; Ronald L Nagel; Ching-Hsuan Tsai; Chien Ho; Muthuchidambaram Prabhakaran; Seetharama A Acharya
Hemoglobin Einstein: semisynthetic deletion in the B-helix of the alpha-chain.
Protein science : a publication of the Protein Society 2004;13(5):1266-75.
2004: Eric S Peterson; Roman Shinder; Imran Khan; Laura Juczszak; Jiaqian Wang; Belur N Manjula; Seetharama A Acharya; Celia Bonaventura; Joel Mitchel Friedman
Domain-specific effector interactions within the central cavity of human adult hemoglobin in solution and in porous sol-gel matrices: evidence for long-range communication pathways.
Biochemistry 2004;43(16):4832-43.
2003: Seetharama A Acharya; Ashok Malavalli; Eric Peterson; Philip D Sun; Chien Ho; Muthuchidambaram Prabhakaran; Arthur Arnone; Belur N Manjula; Joel Mitchel Friedman
Probing the conformation of hemoglobin presbyterian in the R-state.
Journal of protein chemistry 2003;22(3):221-30.
2003: Belur N Manjula; Amy Tsai; R Upadhya; Krishnaveni Perumalsamy; Paul K Smith; Ashok Malavalli; Kim Vandegriff; Robert M Winslow; Marcos Intaglietta; Muthuchidambaram Prabhakaran; Joel Mitchel Friedman; Seetharama A Acharya
Site-specific PEGylation of hemoglobin at Cys-93(beta): correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain.
Bioconjugate chemistry 2003;14(2):464-72.
2003: Belur N Manjula; Seetharama A Acharya
Purification and molecular analysis of hemoglobin by high-performance liquid chromatography.
Methods in molecular medicine 2003;82():31-47.
2002: Steven Deem; Joung Uk Kim; Belur N Manjula; Seetharama A Acharya; Mark E Kerr; Rakesh P Patel; Mark T Gladwin; Erik R Swenson
Effects of S-nitrosation and cross-linking of hemoglobin on hypoxic pulmonary vasoconstriction in isolated rat lungs.
Circulation research 2002;91(7):626-32.
2002: Laura J Juszczak; Belur N Manjula; Celia Bonaventura; Seetharama A Acharya; Joel Mitchel Friedman
UV resonance Raman study of beta93-modified hemoglobin A: chemical modifier-specific effects and added influences of attached poly(ethylene glycol) chains.
Biochemistry 2002;41(1):376-85.
2001: Imran Khan; David Dantsker; Uri Samuni; Adam J Friedman; Celia Bonaventura; Belur N Manjula; Seetharama A Acharya; Joel Mitchel Friedman
Beta 93 modified hemoglobin: kinetic and conformational consequences.
Biochemistry 2001;40(25):7581-92.
2001: Belur N Manjula; Ashok Malavalli; Muthuchidambaram Prabhakaran; Joel Mitchel Friedman; Seetharama A Acharya
Activation of the low oxygen affinity-inducing potential of the Asn108(beta)-->Lys mutation of Hb-Presbyterian on intramolecular alpha alpha-fumaryl cross-bridging.
Protein engineering 2001;14(5):359-66.
2000: M J Rao; Ashok Malavalli; Belur N Manjula; R Kumar; Muthuchidambaram Prabhakaran; DP Sun; Nancy T Ho; Chien Ho; Ronald L Nagel; Seetharama A Acharya
Interspecies hybrid HbS: complete neutralization of Val6(beta)-dependent polymerization of human beta-chain by pig alpha-chains.
Journal of molecular biology 2000;300(5):1389-406.
2000: Ashok Malavalli; Belur N Manjula; Joel Mitchel Friedman; Seetharama A Acharya
Perturbation of the intermolecular contact regions (molecular surface) of hemoglobin S by intramolecular low-O2-affinity-inducing central cavity cross-bridges.
Journal of protein chemistry 2000;19(4):255-67.
2000: Belur N Manjula; Ashok Malavalli; Paul K Smith; Nei-Li Chan; Arthur Arnone; Joel Mitchel Friedman; Seetharama A Acharya
Cys-93-betabeta-succinimidophenyl polyethylene glycol 2000 hemoglobin A. Intramolecular cross-bridging of hemoglobin outside the central cavity.
The Journal of biological chemistry 2000;275(8):5527-34.
1999: David Gottfried; Belur N Manjula; Ashok Malavalli; Seetharama A Acharya; Joel Mitchel Friedman
Probing the diphosphoglycerate binding pocket of HbA and HbPresbyterian (beta 108Asn --> Lys).
Biochemistry 1999;38(35):11307-15.
1998: Belur N Manjula; R Kumar; DP Sun; Nancy T Ho; Chien Ho; J M Rao; Ashok Malavalli; Seetharama A Acharya
Correct assembly of human normal adult hemoglobin when expressed in transgenic swine: chemical, conformational and functional equivalence with the human-derived protein.
Protein engineering 1998;11(7):583-8.
1996: M J Rao; Belur N Manjula; R Kumar; Seetharama A Acharya
Chimeric hemoglobins--hybrids of human and swine hemoglobin: assembly and stability of interspecies hybrids.
Protein science : a publication of the Protein Society 1996;5(5):956-65.
1995: Belur N Manjula; P K Smith; Ashok Malavalli; Seetharama A Acharya
Intramolecular cross-linking of oxy hemoglobin by bis sulfosuccinimidyl suberate and sebacate: generation of cross-linked hemoglobin with reduced oxygen affinity.
Artificial cells, blood substitutes, and immobilization biotechnology 1995;23(3):311-8.
1994: J K O'Donnell; P Birch; C T Parsons; S P White; J Okabe; M J Martin; C Adams; K Sundarapandiyan; Belur N Manjula; Seetharama A Acharya
Influence of the chemical nature of side chain at beta 108 of hemoglobin A on the modulation of the oxygen affinity by chloride ions. Low oxygen affinity variants of human hemoglobin expressed in transgenic pigs: hemoglobins Presbyterian and Yoshizuka.
The Journal of biological chemistry 1994;269(44):27692-9.
1994: A Sharma; A M Khoury-Christianson; S P White; N K Dhanjal; W Huang; C Paulhiac; E J Friedman; Belur N Manjula; R Kumar
High-efficiency synthesis of human alpha-endorphin and magainin in the erythrocytes of transgenic mice: a production system for therapeutic peptides.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9337-41.
1994: Belur N Manjula; R P Roy; P K Smith; Seetharama A Acharya
Bissulfosuccinimidyl esters of aliphatic dicarboxylic acids: a new class of 'affinity directed' beta beta crosslinkers of HbA.
Artificial cells, blood substitutes, and immobilization biotechnology 1994;22(3):747-52.
1994: M J Rao; K Schneider; Brian T Chait; T L Chao; H Keller; S Anderson; Belur N Manjula; R Kumar; Seetharama A Acharya
Recombinant hemoglobin A produced in transgenic swine: structural equivalence with human hemoglobin A.
Artificial cells, blood substitutes, and immobilization biotechnology 1994;22(3):695-700.
1993: C R Tinsley; Belur N Manjula; Emil C Gotschlich
Purification and characterization of polyphosphate kinase from Neisseria meningitidis.
Infection and immunity 1993;61(9):3703-10.
1992: Seetharama A Acharya; K S Iyer; G Sahni; K M Khandke; Belur N Manjula
Restriction in the conformational flexibility of apoproteins in the presence of organic cosolvents: a consequence of the formation of "native-like conformation".
Journal of protein chemistry 1992;11(5):527-38.
1992: R P Roy; K M Khandke; Belur N Manjula; Seetharama A Acharya
Helix formation in enzymically ligated peptides as a driving force for the synthetic reaction: example of alpha-globin semisynthetic reaction.
Biochemistry 1992;31(32):7249-55.
1991: Belur N Manjula; K M Khandke; T Fairwell; W A Relf; Kadaba S Sriprakash
Heptad motifs within the distal subdomain of the coiled-coil rod region of M protein from rheumatic fever and nephritis associated serotypes of group A streptococci are distinct from each other: nucleotide sequence of the M57 gene and relation of the deduced amino acid sequence to other M proteins.
Journal of protein chemistry 1991;10(4):369-84.
1991: K M Khandke; T Fairwell; E H Braswell; Belur N Manjula
The amino-terminal region of group A streptococcal M protein determines its molecular state of assembly and function.
Journal of protein chemistry 1991;10(1):49-59.
1990: K M Khandke; T Fairwell; Seetharama A Acharya; Belur N Manjula
Domain structure and molecular flexibility of streptococcal M protein in situ probed by limited proteolysis.
Journal of protein chemistry 1990;9(5):511-22.
1989: K M Khandke; T Fairwell; Brian T Chait; Belur N Manjula
Influence of ions on cyclization of the amino terminal glutamine residues of tryptic peptides of streptococcal PepM49 protein. Resolution of cyclized peptides by HPLC and characterization by mass spectrometry.
International journal of peptide and protein research 1989;34(2):118-23.
1988: Belur N Manjula
Molecular aspects of the phagocytosis resistance of group A streptococci.
European journal of epidemiology 1988;4(3):289-300.
1988: Seetharama A Acharya; Y J Cho; Belur N Manjula
Cross-linking of proteins by aldotriose: reaction of the carbonyl function of the keto amines generated in situ with amino groups.
Biochemistry 1988;27(12):4522-9.
1988: K M Khandke; T Fairwell; Seetharama A Acharya; Benes Trus; Belur N Manjula
Complete amino acid sequence of streptococcal PepM49 protein, a nephritis-associated serotype. Conserved conformational design among sequentially distinct M protein serotypes.
The Journal of biological chemistry 1988;263(11):5075-82.
1988: Vincent Fischetti; D A Parry; Benes Trus; Susan Kay Hollingshead; June R Scott; Belur N Manjula
Conformational characteristics of the complete sequence of group A streptococcal M6 protein.
Proteins 1988;3(1):60-9.
1987: K M Khandke; T Fairwell; Belur N Manjula
Difference in the structural features of streptococcal M proteins from nephritogenic and rheumatogenic serotypes.
The Journal of experimental medicine 1987;166(1):151-62.
1987: Seetharama A Acharya; Belur N Manjula
Dihydroxypropylation of amino groups of proteins: use of glyceraldehyde as a reversible agent for reductive alkylation.
Biochemistry 1987;26(12):3524-30.
1987: Sheenah Mische; Belur N Manjula; Vincent Fischetti
Relation of streptococcal M protein with human and rabbit tropomyosin: the complete amino acid sequence of human cardiac alpha tropomyosin, a highly conserved contractile protein.
Biochemical and biophysical research communications 1987;142(3):813-8.
1986: Belur N Manjula; Seetharama A Acharya; T Fairwell; Vincent Fischetti
Antigenic domains of the streptococcal Pep M5 protein. Localization of epitopes crossreactive with type 6 M protein and identification of a hypervariable region of the M molecule.
The Journal of experimental medicine 1986;163(1):129-38.
1985: K F Jones; Belur N Manjula; K H Johnston; Susan Kay Hollingshead; June R Scott; Vincent Fischetti
Location of variable and conserved epitopes among the multiple serotypes of streptococcal M protein.
The Journal of experimental medicine 1985;161(3):623-8.
1985: Belur N Manjula; Benes Trus; Vincent Fischetti
Presence of two distinct regions in the coiled-coil structure of the streptococcal Pep M5 protein: relationship to mammalian coiled-coil proteins and implications to its biological properties.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(4):1064-8.
1984: Seetharama A Acharya; L G Sussman; Belur N Manjula
Application of reductive dihydroxypropylation of amino groups of proteins in primary structural studies: identification of phenylthiohydantoin derivative of epsilon-dihydroxypropyl-lysine residues by high-performance liquid chromatography.
Journal of chromatography 1984;297():37-48.
1984: Vincent Fischetti; K F Jones; Belur N Manjula; June R Scott
Streptococcal M6 protein expressed in Escherichia coli. Localization, purification, and comparison with streptococcal-derived M protein.
The Journal of experimental medicine 1984;159(4):1083-95.
1984: Belur N Manjula; Seetharama A Acharya; Sheenah Mische; T Fairwell; Vincent Fischetti
The complete amino acid sequence of a biologically active 197-residue fragment of M protein isolated from type 5 group A streptococci.
The Journal of biological chemistry 1984;259(6):3686-93.
1983: Belur N Manjula; Sheenah Mische; Vincent Fischetti
Primary structure of streptococcal Pep M5 protein: Absence of extensive sequence repeats.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(18):5475-9.
1983: Seetharama A Acharya; Alberto Di Donato; Belur N Manjula; Vincent Fischetti; J M Manning
Influence of trifluoroacetic acid on retention times of histidine-containing tryptic peptides in reverse phase HPLC.
International journal of peptide and protein research 1983;22(1):78-82.