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Alexander Mankin
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Research Profile (preview)
Chemicals & Drugs
Anatomy
Concepts & Ideas
Living Beings
Physiology
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Network (preview)
16
Xiong, Liqun
12
Tenson, Tanel
6
Kloss, PS
5
Shinabarger, Dean
4
Polacek, Norbert
4
Khaitovich, P
4
Noller, Harry
3
Swaney, Steven
3
Yassin, Aymen
3
Garrett, Roger
2
Bocchetta, Maurizio
2
Böttger, Erik
2
Lancaster, Laura
2
Colca, Jerry
2
Douthwaite, Stephen
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Publications
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All Publications
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2009: Llano-Sotelo Beatriz; Klepacki Dorota; Mankin Alexander S
Selection of small peptides, inhibitors of translation.
Journal of molecular biology 2009;391(5):813-9.
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2009: Llano-Sotelo Beatriz; Hickerson Robyn P; Lancaster Laura; Noller Harry F; Mankin Alexander S
Fluorescently labeled ribosomes as a tool for analyzing antibiotic binding.
RNA (New York, N.Y.) 2009;15(8):1597-604.
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2009: Ramu Haripriya; Mankin Alexander; Vazquez-Laslop Nora
Programmed drug-dependent ribosome stalling.
Molecular microbiology 2009;71(4):811-24.
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2009: Siibak Triinu; Peil Lauri; Xiong Liqun; Mankin Alexander; Remme Jaanus; Tenson Tanel
Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition.
Antimicrobial agents and chemotherapy 2009;53(2):563-71.
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2008: Mankin Alexander S
Macrolide myths.
Current opinion in microbiology 2008;11(5):414-21.
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2008: Toh Seok-Ming; Mankin Alexander S
An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors.
Journal of molecular biology 2008;380(4):593-7.
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2008: Smith Lisa K; Mankin Alexander S
Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors.
Antimicrobial agents and chemotherapy 2008;52(5):1703-12.
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2008: Vazquez-Laslop Nora; Thum Celine; Mankin Alexander S
Molecular mechanism of drug-dependent ribosome stalling.
Molecular cell 2008;30(2):190-202.
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2008: Samant Shalaka; Lee Hyunwoo; Ghassemi Mahmood; Chen Juan; Cook James L; Mankin Alexander S; Neyfakh Alexander A
Nucleotide biosynthesis is critical for growth of bacteria in human blood.
PLoS pathogens 2008;4(2):e37.
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2008: Toh Seok-Ming; Xiong Liqun; Bae Taeok; Mankin Alexander S
The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA.
RNA (New York, N.Y.) 2008;14(1):98-106.
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2008: Mankin Alexander S; Polacek Norbert
SPARK: a new peptidyl transferase activity assay.
Methods in molecular medicine 2008;142():107-16.
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2007: Yassin Aymen; Mankin Alexander S
Potential new antibiotic sites in the ribosome revealed by deleterious mutations in RNA of the large ribosomal subunit.
The Journal of biological chemistry 2007;282(33):24329-42.
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2007: Toh Seok-Ming; Xiong Liqun; Arias Cesar A; Villegas Maria V; Lolans Karen; Quinn John; Mankin Alexander S
Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid.
Molecular microbiology 2007;64(6):1506-14.
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2007: Leach Karen L; Swaney Steven M; Colca Jerry R; McDonald William G; Blinn James R; Thomasco Lisa M; Gadwood Robert C; Shinabarger Dean; Xiong Liqun; Mankin Alexander S
The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria.
Molecular cell 2007;26(3):393-402.
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2006: Tenson Tanel; Mankin Alexander
Antibiotics and the ribosome.
Molecular microbiology 2006;59(6):1664-77.
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2006: Mankin Alexander S
Nascent peptide in the "birth canal" of the ribosome.
Trends in biochemical sciences 2006;31(1):11-3.
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2005: Yassin Aymen; Fredrick Kurt; Mankin Alexander S
Deleterious mutations in small subunit ribosomal RNA identify functional sites and potential targets for antibiotics.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16620-5.
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2005: Beringer Malte; Bruell Christian; Xiong Liqun; Pfister Peter; Bieling Peter; Katunin Vladimir I; Mankin Alexander S; Böttger Erik C; Rodnina Marina V
Essential mechanisms in the catalysis of peptide bond formation on the ribosome.
The Journal of biological chemistry 2005;280(43):36065-72.
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2005: Polacek Norbert; Mankin Alexander S
The ribosomal peptidyl transferase center: structure, function, evolution, inhibition.
Critical reviews in biochemistry and molecular biology 2005;40(5):285-311.
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2005: Xiong Liqun; Korkhin Yakov; Mankin Alexander S
Binding site of the bridged macrolides in the Escherichia coli ribosome.
Antimicrobial agents and chemotherapy 2005;49(1):281-8.
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2005: Erlacher Matthias D; Lang Kathrin; Shankaran Nisha; Wotzel Brigitte; Hüttenhofer Alexander; Micura Ronald; Mankin Alexander S; Polacek Norbert
Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451.
Nucleic acids research 2005;33(5):1618-27.
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2004: Vimberg Vladimir; Xiong Liqun; Bailey Marne; Tenson Tanel; Mankin Alexander
Peptide-mediated macrolide resistance reveals possible specific interactions in the nascent peptide exit tunnel.
Molecular microbiology 2004;54(2):376-85.
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2003: Ruggero Kathleen A; Schroeder Laura K; Schreckenberger Paul C; Mankin Alexander S; Quinn John P
Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: evidence for a gene dosage effect on linezolid MICs.
Diagnostic microbiology and infectious disease 2003;47(3):511-3.
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2003: Colca Jerry R; McDonald William G; Waldon Daniel J; Thomasco Lisa M; Gadwood Robert C; Lund Eric T; Cavey Gregory S; Mathews W Rodney; Adams Lonnie D; Cecil Eric T; Pearson James D; Bock Jeffrey H; Mott John E; Shinabarger Dean L; Xiong Liqun; Mankin Alexander S
Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics.
The Journal of biological chemistry 2003;278(24):21972-9.
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2003: Polacek Norbert; Gomez Maria J; Ito Koichi; Xiong Liqun; Nakamura Yoshikazu; Mankin Alexander
The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination.
Molecular cell 2003;11(1):103-12.
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2003: Gaynor Marne; Mankin Alexander S
Macrolide antibiotics: binding site, mechanism of action, resistance.
Current topics in medicinal chemistry 2003;3(9):949-61.
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2002: Sander P; Belova L; Kidan Y G; Pfister P; Mankin A S; Böttger E C
Ribosomal and non-ribosomal resistance to oxazolidinones: species-specific idiosyncrasy of ribosomal alterations.
Molecular microbiology 2002;46(5):1295-304.
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2002: Polacek Norbert; Swaney Steven; Shinabarger Dean; Mankin Alexander S
SPARK--a novel method to monitor ribosomal peptidyl transferase activity.
Biochemistry 2002;41(39):11602-10.
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2001: Garza-Ramos G; Xiong L; Zhong P; Mankin A
Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA.
Journal of bacteriology 2001;183(23):6898-907.
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2001: Xiong L; Polacek N; Sander P; Böttger E C; Mankin A
pKa of adenine 2451 in the ribosomal peptidyl transferase center remains elusive.
RNA (New York, N.Y.) 2001;7(10):1365-9.
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2001: Tenson T; Mankin A S
Short peptides conferring resistance to macrolide antibiotics.
Peptides 2001;22(10):1661-8.
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2001: Mann P A; Xiong L; Mankin A S; Chau A S; Mendrick C A; Najarian D J; Cramer C A; Loebenberg D; Coates E; Murgolo N J; Aarestrup F M; Goering R V; Black T A; Hare R S; McNicholas P M
EmtA, a rRNA methyltransferase conferring high-level evernimicin resistance.
Molecular microbiology 2001;41(6):1349-56.
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2001: Polacek N; Gaynor M; Yassin A; Mankin A S
Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide.
Nature 2001;411(6836):498-501.
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2001: Belova L; Tenson T; Xiong L; McNicholas P M; Mankin A S
A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3726-31.
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2001: Bocchetta M; Xiong L; Shah S; Mankin A S
Interactions between 23S rRNA and tRNA in the ribosomal E site.
RNA (New York, N.Y.) 2001;7(1):54-63.
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2000: Xiong L; Kloss P; Douthwaite S; Andersen N M; Swaney S; Shinabarger D L; Mankin A S
Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.
Journal of bacteriology 2000;182(19):5325-31.
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2000: Velichutina I V; Dresios J; Hong J Y; Li C; Mankin A; Synetos D; Liebman S W
Mutations in helix 27 of the yeast Saccharomyces cerevisiae 18S rRNA affect the function of the decoding center of the ribosome.
RNA (New York, N.Y.) 2000;6(8):1174-84.
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1999: Kloss P; Xiong L; Shinabarger D L; Mankin A S
Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center.
Journal of molecular biology 1999;294(1):93-101.
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1999: Khaitovich P; Mankin A S
Effect of antibiotics on large ribosomal subunit assembly reveals possible function of 5 S rRNA.
Journal of molecular biology 1999;291(5):1025-34.
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1999: Mankin A S; Liebman S W
Baby, don't stop!
Nature genetics 1999;23(1):8-10.
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1999: Chernyaeva N S; Murgola E J; Mankin A S
Suppression of nonsense mutations induced by expression of an RNA complementary to a conserved segment of 23S rRNA.
Journal of bacteriology 1999;181(17):5257-62.
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1999: Khaitovich P; Tenson T; Mankin A S; Green R
Peptidyl transferase activity catalyzed by protein-free 23S ribosomal RNA remains elusive.
RNA (New York, N.Y.) 1999;5(5):605-8.
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1999: Tenson T; Herrera J V; Kloss P; Guarneros G; Mankin A S
Inhibition of translation and cell growth by minigene expression.
Journal of bacteriology 1999;181(5):1617-22.
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1999: Khaitovich P; Tenson T; Kloss P; Mankin A S
Reconstitution of functionally active Thermus aquaticus large ribosomal subunits with in vitro-transcribed rRNA.
Biochemistry 1999;38(6):1780-8.
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1999: Xiong L; Shah S; Mauvais P; Mankin A S
A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre.
Molecular microbiology 1999;31(2):633-9.
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1999: Khaitovich P; Mankin A S; Green R; Lancaster L; Noller H F
Characterization of functionally active subribosomal particles from Thermus aquaticus.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):85-90.
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1998: Tripathi S; Kloss P S; Mankin A S
Ketolide resistance conferred by short peptides.
The Journal of biological chemistry 1998;273(32):20073-7.
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1998: Arkov A L; Mankin A; Murgola E J
An rRNA fragment and its antisense can alter decoding of genetic information.
Journal of bacteriology 1998;180(10):2744-8.
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1998: Bocchetta M; Xiong L; Mankin A S
23S rRNA positions essential for tRNA binding in ribosomal functional sites.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3525-30.
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1997: Mankin A S
Pactamycin resistance mutations in functional sites of 16 S rRNA.
Journal of molecular biology 1997;274(1):8-15.
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1997: Tenson T; Xiong L; Kloss P; Mankin A S
Erythromycin resistance peptides selected from random peptide libraries.
The Journal of biological chemistry 1997;272(28):17425-30.
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1996: Tan G T; DeBlasio A; Mankin A S
Mutations in the peptidyl transferase center of 23 S rRNA reveal the site of action of sparsomycin, a universal inhibitor of translation.
Journal of molecular biology 1996;261(2):222-30.
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1996: Dam M; Douthwaite S; Tenson T; Mankin A S
Mutations in domain II of 23 S rRNA facilitate translation of a 23 S rRNA-encoded pentapeptide conferring erythromycin resistance.
Journal of molecular biology 1996;259(1):1-6.
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1996: Tenson T; DeBlasio A; Mankin A
A functional peptide encoded in the Escherichia coli 23S rRNA.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5641-6.
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1995: Tenson T; Mankin A
Comparison of functional peptide encoded in the Escherichia coli 23S rRNA with other peptides involved in cis-regulation of translation.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1995;73(11-12):1061-70.
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1995: Noller H F; Green R; Heilek G; Hoffarth V; Hüttenhofer A; Joseph S; Lee I; Lieberman K; Mankin A; Merryman C
Structure and function of ribosomal RNA.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1995;73(11-12):997-1009.
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1994: Mankin A S; Leviev I; Garrett R A
Cross-hypersensitivity effects of mutations in 23 S rRNA yield insight into aminoacyl-tRNA binding.
Journal of molecular biology 1994;244(2):151-7.
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1994: Leviev I G; Rodriguez-Fonseca C; Phan H; Garrett R A; Heilek G; Noller H F; Mankin A S
A conserved secondary structural motif in 23S rRNA defines the site of interaction of amicetin, a universal inhibitor of peptide bond formation.
The EMBO journal 1994;13(7):1682-6.
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1991: Garrett R A; Dalgaard J; Larsen N; Kjems J; Mankin A S
Archaeal rRNA operons.
Trends in biochemical sciences 1991;16(1):22-6.
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