James Manley

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TOP 3
Chen Mo; Manley James L
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches.
Beckerman Rachel; Donner Aaron J; Mattia Melissa; Peart Melissa J; Manley James L; Espinosa Joaquin M; Prives Carol
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.
Richard Patricia; Manley James L
Transcription termination by nuclear RNA polymerases.

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All Publications

2009: Chen Mo; Manley James L
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches.
Nature reviews. Molecular cell biology 2009;10(11):741-54.
2009: Beckerman Rachel; Donner Aaron J; Mattia Melissa; Peart Melissa J; Manley James L; Espinosa Joaquin M; Prives Carol
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.
Genes & development 2009;23(11):1364-77.
2009: Richard Patricia; Manley James L
Transcription termination by nuclear RNA polymerases.
Genes & development 2009;23(11):1247-69.
2009: Feng Ying; Valley Matthew T; Lazar Josef; Yang Allison L; Bronson Roderick T; Firestein Stuart; Coetzee William A; Manley James L
SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart.
Developmental cell 2009;16(4):528-38.
2009: Rosonina Emanuel; Willis Ian M; Manley James L
Sub1 functions in osmoregulation and in transcription by both RNA polymerases II and III.
Molecular and cellular biology 2009;29(8):2308-21.
2009: Xiang Song; Cooper-Morgan Amalene; Jiao Xinfu; Kiledjian Megerditch; Manley James L; Tong Liang
Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.
Nature 2009;458(7239):784-8.
2009: Shi Yongsheng; Di Giammartino Dafne Campigli; Taylor Derek; Sarkeshik Ali; Rice William J; Yates John R; Frank Joachim; Manley James L
Molecular architecture of the human pre-mRNA 3' processing complex.
Molecular cell 2009;33(3):365-76.
2009: Rozenblatt-Rosen Orit; Nagaike Takashi; Francis Joshua M; Kaneko Syuzo; Glatt Karen A; Hughes Christina M; LaFramboise Thomas; Manley James L; Meyerson Matthew
The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):755-60.
2008: Feng Ying; Chen Mo; Manley James L
Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator.
Nature structural & molecular biology 2008;15(10):1040-8.
2008: Vethantham Vasupradha; Rao Nishta; Manley James L
Sumoylation regulates multiple aspects of mammalian poly(A) polymerase function.
Genes & development 2008;22(4):499-511.
2008: David Charles J; Manley James L
The search for alternative splicing regulators: new approaches offer a path to a splicing code.
Genes & development 2008;22(3):279-85.
2008: Bush Stephanie D; Richard Patricia; Manley James L
Variations in intracellular levels of TATA binding protein can affect specific genes by different mechanisms.
Molecular and cellular biology 2008;28(1):83-92.
2007: Xu Yu-Xin; Manley James L
New insights into mitotic chromosome condensation: a role for the prolyl isomerase Pin1.
Cell cycle (Georgetown, Tex.) 2007;6(23):2896-901.
2007: Li Xialu; Niu Tianhui; Manley James L
The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability.
RNA (New York, N.Y.) 2007;13(12):2108-15.
2007: Valadkhan Saba; Mohammadi Afshin; Wachtel Chaim; Manley James L
Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing.
RNA (New York, N.Y.) 2007;13(12):2300-11.
2007: Vethantham Vasupradha; Rao Nishta; Manley James L
Sumoylation modulates the assembly and activity of the pre-mRNA 3' processing complex.
Molecular and cellular biology 2007;27(24):8848-58.
2007: Xu Yu-Xin; Manley James L
Pin1 modulates RNA polymerase II activity during the transcription cycle.
Genes & development 2007;21(22):2950-62.
2007: Kaneko Syuzo; Chu Chun; Shatkin Aaron J; Manley James L
Human capping enzyme promotes formation of transcriptional R loops in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17620-5.
2007: Shi Yongsheng; Manley James L
A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock.
Molecular cell 2007;28(1):79-90.
2007: Lazarev Denis; Manley James L
Concurrent splicing and transcription are not sufficient to enhance splicing efficiency.
RNA (New York, N.Y.) 2007;13(9):1546-57.
2007: Kaneko Syuzo; Rozenblatt-Rosen Orit; Meyerson Matthew; Manley James L
The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination.
Genes & development 2007;21(14):1779-89.
2007: Xu Yu-Xin; Manley James L
The prolyl isomerase Pin1 functions in mitotic chromosome condensation.
Molecular cell 2007;26(2):287-300.
2007: Bai Yun; Auperin Thierry C; Chou Chi-Yuan; Chang Gu-Gang; Manley James L; Tong Liang
Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors.
Molecular cell 2007;25(6):863-75.
2007: Kashima Tsuyoshi; Rao Nishta; Manley James L
An intronic element contributes to splicing repression in spinal muscular atrophy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3426-31.
2006: Mandel Corey R; Kaneko Syuzo; Zhang Hailong; Gebauer Damara; Vethantham Vasupradha; Manley James L; Tong Liang
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease.
Nature 2006;444(7121):953-6.
2006: Shi Yongsheng; Reddy Bharat; Manley James L
PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins.
Molecular cell 2006;23(6):819-29.
2006: Li Xialu; Manley James L
Cotranscriptional processes and their influence on genome stability.
Genes & development 2006;20(14):1838-47.
2006: Li Xialu; Manley James L
Alternative splicing and control of apoptotic DNA fragmentation.
Cell cycle (Georgetown, Tex.) 2006;5(12):1286-8.
2006: Rosonina Emanuel; Kaneko Syuzo; Manley James L
Terminating the transcript: breaking up is hard to do.
Genes & development 2006;20(9):1050-6.
2006: Bush Stephanie; Manley James L
Transcription and RNA processing factors play complex roles in DT40 cells.
Sub-cellular biochemistry 2006;40():207-23.
2005: Li Xialu; Manley James L
New talents for an old acquaintance: the SR protein splicing factor ASF/SF2 functions in the maintenance of genome stability.
Cell cycle (Georgetown, Tex.) 2005;4(12):1706-8.
2005: Li Xialu; Wang Jin; Manley James L
Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation.
Genes & development 2005;19(22):2705-14.
2005: Rosonina Emanuel; Manley James L
From transcription to mRNA: PAF provides a new path.
Molecular cell 2005;20(2):167-8.
2005: Kaneko Syuzo; Manley James L
The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3' end formation.
Molecular cell 2005;20(1):91-103.
2005: Shin Chanseok; Kleiman Frida E; Manley James L
Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins.
Molecular and cellular biology 2005;25(18):8334-43.
2005: Li Xialu; Manley James L
Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability.
Cell 2005;122(3):365-78.
2005: Kleiman Frida E; Wu-Baer Foon; Fonseca Danae; Kaneko Syuzo; Baer Richard; Manley James L
BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.
Genes & development 2005;19(10):1227-37.
2005: Calvo Olga; Manley James L
The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription.
The EMBO journal 2005;24(5):1009-20.
2005: Millhouse Scott; Manley James L
The C-terminal domain of RNA polymerase II functions as a phosphorylation-dependent splicing activator in a heterologous protein.
Molecular and cellular biology 2005;25(2):533-44.
2004: Barnard Daron C; Ryan Kevin; Manley James L; Richter Joel D
Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.
Cell 2004;119(5):641-51.
2004: Shin Chanseok; Manley James L
Cell signalling and the control of pre-mRNA splicing.
Nature reviews. Molecular cell biology 2004;5(9):727-38.
2004: Ryan Kevin; Calvo Olga; Manley James L
Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease.
RNA (New York, N.Y.) 2004;10(4):565-73.
2004: Xu Yu-Xin; Manley James L
Pinning down transcription: regulation of RNA polymerase II activity during the cell cycle.
Cell cycle (Georgetown, Tex.) 2004;3(4):432-5.
2004: Shin Chanseok; Feng Ying; Manley James L
Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock.
Nature 2004;427(6974):553-8.
2003: Xu Yu-Xin; Hirose Yutaka; Zhou Xiao Zhen; Lu Kun Ping; Manley James L
Pin1 modulates the structure and function of human RNA polymerase II.
Genes & development 2003;17(22):2765-76.
2003: Poyurovsky Masha V; Jacq Xavier; Ma Charles; Karni-Schmidt Orit; Parker Peter J; Chalfie Martin; Manley James L; Prives Carol
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization.
Molecular cell 2003;12(4):875-87.
2003: Chen Zheng; Manley James L
Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates.
Molecular and cellular biology 2003;23(20):7350-62.
2003: Chen Zheng; Manley James L
In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L.
The Journal of biological chemistry 2003;278(37):35172-83.
2003: Kashima Tsuyoshi; Manley James L
A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy.
Nature genetics 2003;34(4):460-3.
2003: Valadkhan Saba; Manley James L
Characterization of the catalytic activity of U2 and U6 snRNAs.
RNA (New York, N.Y.) 2003;9(7):892-904.
2003: Calvo Olga; Manley James L
Strange bedfellows: polyadenylation factors at the promoter.
Genes & development 2003;17(11):1321-7.
2003: Prasad Jayendra; Manley James L
Regulation and substrate specificity of the SR protein kinase Clk/Sty.
Molecular and cellular biology 2003;23(12):4139-49.
2002: Shin Chanseok; Manley James L
The SR protein SRp38 represses splicing in M phase cells.
Cell 2002;111(3):407-17.
2002: Valadkhan Saba; Manley James L
Intrinsic metal binding by a spliceosomal RNA.
Nature structural biology 2002;9(7):498-9.
2002: Chen Angus; Kleiman Frida E; Manley James L; Ouchi Toru; Pan Zhen-Qiang
Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase.
The Journal of biological chemistry 2002;277(24):22085-92.
2002: Shen Baohe; Manley James L
Pelle kinase is activated by autophosphorylation during Toll signaling in Drosophila.
Development (Cambridge, England) 2002;129(8):1925-33.
2002: Ryan Kevin; Murthy Kanneganti G K; Kaneko Syuzo; Manley James L
Requirements of the RNA polymerase II C-terminal domain for reconstituting pre-mRNA 3' cleavage.
Molecular and cellular biology 2002;22(6):1684-92.
2001: Prives C; Manley J L
Why is p53 acetylated?
Cell 2001;107(7):815-8.
2001: Valadkhan S; Manley J L
Splicing-related catalysis by protein-free snRNAs.
Nature 2001;413(6857):701-7.
2001: Shen B; Liu H; Skolnik E Y; Manley J L
Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8596-601.
2001: Calvo O; Manley J L
Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination.
Molecular cell 2001;7(5):1013-23.
2001: Um M; Yamauchi J; Kato S; Manley J L
Heterozygous disruption of the TATA-binding protein gene in DT40 cells causes reduced cdc25B phosphatase expression and delayed mitosis.
Molecular and cellular biology 2001;21(7):2435-48.
2001: Kleiman F E; Manley J L
The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression.
Cell 2001;104(5):743-53.
2000: Mendez R; Murthy K G; Ryan K; Manley J L; Richter J D
Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex.
Molecular cell 2000;6(5):1253-9.
2000: Xu Y; Tao X; Shen B; Horng T; Medzhitov R; Manley J L; Tong L
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Nature 2000;408(6808):111-5.
2000: Shatkin A J; Manley J L
The ends of the affair: capping and polyadenylation.
Nature structural biology 2000;7(10):838-42.
2000: Bond G L; Prives C; Manley J L
Poly(A) polymerase phosphorylation is dependent on novel interactions with cyclins.
Molecular and cellular biology 2000;20(14):5310-20.
2000: Chen Z; Manley J L
Robust mRNA transcription in chicken DT40 cells depleted of TAF(II)31 suggests both functional degeneracy and evolutionary divergence.
Molecular and cellular biology 2000;20(14):5064-76.
2000: Takagaki Y; Manley J L
Complex protein interactions within the human polyadenylation machinery identify a novel component.
Molecular and cellular biology 2000;20(5):1515-25.
2000: Valadkhan S; Manley J L
A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast.
RNA (New York, N.Y.) 2000;6(2):206-19.
2000: Um M; Manley J L
The Drosophila TATA binding protein contains a strong but masked activation domain.
Gene expression 2000;9(3):123-32.
1999: Prasad J; Colwill K; Pawson T; Manley J L
The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing.
Molecular and cellular biology 1999;19(10):6991-7000.
1999: Kleiman F E; Manley J L
Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.
Science (New York, N.Y.) 1999;285(5433):1576-9.
1999: Tacke R; Manley J L
Determinants of SR protein specificity.
Current opinion in cell biology 1999;11(3):358-62.
1999: Hirose Y; Tacke R; Manley J L
Phosphorylated RNA polymerase II stimulates pre-mRNA splicing.
Genes & development 1999;13(10):1234-9.
1999: Tacke R; Manley J L
Functions of SR and Tra2 proteins in pre-mRNA splicing regulation.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1999;220(2):59-63.
1999: Li C; Manley J L
Allosteric regulation of even-skipped repression activity by phosphorylation.
Molecular cell 1999;3(1):77-86.
1998: Takagaki Y; Manley J L
Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation.
Molecular cell 1998;2(6):761-71.
1998: Shen B; Manley J L
Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube.
Development (Cambridge, England) 1998;125(23):4719-28.
1998: Xiao S H; Manley J L
Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2.
The EMBO journal 1998;17(21):6359-67.
1998: Hirose Y; Manley J L
RNA polymerase II is an essential mRNA polyadenylation factor.
Nature 1998;395(6697):93-6.
1998: Zhao W; Manley J L
Deregulation of poly(A) polymerase interferes with cell growth.
Molecular and cellular biology 1998;18(9):5010-20.
1998: Wang J; Xiao S H; Manley J L
Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing.
Genes & development 1998;12(14):2222-33.
1998: Li C; Manley J L
Even-skipped represses transcription by binding TATA binding protein and blocking the TFIID-TATA box interaction.
Molecular and cellular biology 1998;18(7):3771-81.
1998: Sun J S; Valadkhan S; Manley J L
A UV-crosslinkable interaction in human U6 snRNA.
RNA (New York, N.Y.) 1998;4(5):489-97.
1998: Tacke R; Tohyama M; Ogawa S; Manley J L
Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing.
Cell 1998;93(1):139-48.
1998: Jayaraman L; Moorthy N C; Murthy K G; Manley J L; Bustin M; Prives C
High mobility group protein-1 (HMG-1) is a unique activator of p53.
Genes & development 1998;12(4):462-72.
1998: Colgan D F; Murthy K G; Zhao W; Prives C; Manley J L
Inhibition of poly(A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non-consensus sites.
The EMBO journal 1998;17(4):1053-62.
1997: Hirose Y; Manley J L
Creatine phosphate, not ATP, is required for 3' end cleavage of mammalian pre-mRNA in vitro.
The Journal of biological chemistry 1997;272(47):29636-42.
1997: Colgan D F; Manley J L
Mechanism and regulation of mRNA polyadenylation.
Genes & development 1997;11(21):2755-66.
1997: Dantonel J C; Murthy K G; Manley J L; Tora L
Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNA.
Nature 1997;389(6649):399-402.
1997: Takagaki Y; Manley J L
RNA recognition by the human polyadenylation factor CstF.
Molecular and cellular biology 1997;17(7):3907-14.
1997: Sun J S; Manley J L
The human U6 snRNA intramolecular helix: structural constraints and lack of sequence specificity.
RNA (New York, N.Y.) 1997;3(5):514-26.
1997: Wang J; Manley J L
Regulation of pre-mRNA splicing in metazoa.
Current opinion in genetics & development 1997;7(2):205-11.
1997: Tacke R; Chen Y; Manley J L
Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1148-53.
1997: Xiao S H; Manley J L
Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.
Genes & development 1997;11(3):334-44.
1996: Manley J L; Takagaki Y
The end of the message--another link between yeast and mammals.
Science (New York, N.Y.) 1996;274(5292):1481-2.
1996: Takagaki Y; Seipelt R L; Peterson M L; Manley J L
The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation.
Cell 1996;87(5):941-52.
1996: Farmer G; Friedlander P; Colgan J; Manley J L; Prives C
Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein.
Nucleic acids research 1996;24(21):4281-8.
1996: Colgan D F; Murthy K G; Prives C; Manley J L
Cell-cycle related regulation of poly(A) polymerase by phosphorylation.
Nature 1996;384(6606):282-5.
1996: Wang J; Takagaki Y; Manley J L
Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability.
Genes & development 1996;10(20):2588-99.
1996: Farmer G; Colgan J; Nakatani Y; Manley J L; Prives C
Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo.
Molecular and cellular biology 1996;16(8):4295-304.
1996: Manley J L; Tacke R
SR proteins and splicing control.
Genes & development 1996;10(13):1569-79.
1996: Zhao W; Manley J L
Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms.
Molecular and cellular biology 1996;16(5):2378-86.
1996: Norris J L; Manley J L
Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal.
Genes & development 1996;10(7):862-72.
1996: Manley J L; Um M; Li C; Ashali H
Mechanisms of transcriptional activation and repression can both involve TFIID.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1339):517-26.
1996: Colwill K; Pawson T; Andrews B; Prasad J; Manley J L; Bell J C; Duncan P I
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.
The EMBO journal 1996;15(2):265-75.
1995: Murthy K G; Manley J L
The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation.
Genes & development 1995;9(21):2672-83.
1995: Um M; Li C; Manley J L
The transcriptional repressor even-skipped interacts directly with TATA-binding protein.
Molecular and cellular biology 1995;15(9):5007-16.
1995: Jamison S F; Pasman Z; Wang J; Will C; Lührmann R; Manley J L; Garcia-Blanco M A
U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.
Nucleic acids research 1995;23(16):3260-7.
1995: Tacke R; Manley J L
The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.
The EMBO journal 1995;14(14):3540-51.
1995: Wang J; Manley J L
Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways.
RNA (New York, N.Y.) 1995;1(3):335-46.
1995: Colgan J; Ashali H; Manley J L
A direct interaction between a glutamine-rich activator and the N terminus of TFIIB can mediate transcriptional activation in vivo.
Molecular and cellular biology 1995;15(4):2311-20.
1995: Sun J S; Manley J L
A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing.
Genes & development 1995;9(7):843-54.
1995: Manley J L
A complex protein assembly catalyzes polyadenylation of mRNA precursors.
Current opinion in genetics & development 1995;5(2):222-8.
1995: Colgan J; Manley J L
Cooperation between core promoter elements influences transcriptional activity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):1955-9.
1995: Manley J L
Messenger RNA polyadenylylation: a universal modification.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):1800-1.
1995: Norris J L; Manley J L
Regulation of dorsal in cultured cells by Toll and tube: tube function involves a novel mechanism.
Genes & development 1995;9(3):358-69.
1994: Takagaki Y; Manley J L
A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein.
Nature 1994;372(6505):471-4.
1994: Raabe T; Murthy K G; Manley J L
Poly(A) polymerase contains multiple functional domains.
Molecular and cellular biology 1994;14(5):2946-57.
1994: Zuo P; Manley J L
The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3363-7.
1994: Kohtz J D; Jamison S F; Will C L; Zuo P; Lührmann R; Garcia-Blanco M A; Manley J L
Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors.
Nature 1994;368(6467):119-24.
1994: Manley J L; Proudfoot N J
RNA 3' ends: formation and function--meeting review.
Genes & development 1994;8(3):259-64.
1993: Zuo P; Manley J L
Functional domains of the human splicing factor ASF/SF2.
The EMBO journal 1993;12(12):4727-37.
1993: Han K; Manley J L
Functional domains of the Drosophila Engrailed protein.
The EMBO journal 1993;12(7):2723-33.
1993: Woppmann A; Will C L; Kornstädt U; Zuo P; Manley J L; Lührmann R
Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.
Nucleic acids research 1993;21(12):2815-22.
1993: Colgan J; Wampler S; Manley J L
Interaction between a transcriptional activator and transcription factor IIB in vivo.
Nature 1993;362(6420):549-53.
1993: Han K; Manley J L
Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain.
Genes & development 1993;7(3):491-503.
1992: Read D; Manley J L
Transcriptional regulators of Drosophila embryogenesis.
Biochimica et biophysica acta 1992;1114(2-3):79-93.
1992: Wu J; Manley J L
Multiple functional domains of human U2 small nuclear RNA: strengthening conserved stem I can block splicing.
Molecular and cellular biology 1992;12(12):5464-73.
1992: Takagaki Y; Manley J L
A human polyadenylation factor is a G protein beta-subunit homologue.
The Journal of biological chemistry 1992;267(33):23471-4.
1992: Read D; Levine M; Manley J L
Ectopic expression of the Drosophila tramtrack gene results in multiple embryonic defects, including repression of even-skipped and fushi tarazu.
Mechanisms of development 1992;38(3):183-95.
1992: Norris J L; Manley J L
Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A.
Genes & development 1992;6(9):1654-67.
1992: Murthy K G; Manley J L
Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus.
The Journal of biological chemistry 1992;267(21):14804-11.
1992: Read D; Manley J L
Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities.
The EMBO journal 1992;11(3):1035-44.
1992: Takagaki Y; MacDonald C C; Shenk T; Manley J L
The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1403-7.
1992: Colgan J; Manley J L
TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters.
Genes & development 1992;6(2):304-15.
1991: Raabe T; Manley J L
A human homologue of the Escherichia coli DnaJ heat-shock protein.
Nucleic acids research 1991;19(23):6645.
1991: Han Y M; Dahlberg J; Lund E; Manley J L; Prives C
SV40 T-antigen-binding sites within the 5'-flanking regions of human U1 and U2 genes.
Gene 1991;109(2):219-31.
1991: Raabe T; Bollum F J; Manley J L
Primary structure and expression of bovine poly(A) polymerase.
Nature 1991;353(6341):229-34.
1991: Wu J A; Manley J L
Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA.
Nature 1991;352(6338):818-21.
1991: Ge H; Zuo P; Manley J L
Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators.
Cell 1991;66(2):373-82.
1991: Murthy K G; Park P; Manley J L
A nuclear micrococcal-sensitive, ATP-dependent exoribonuclease degrades uncapped but not capped RNA substrates.
Nucleic acids research 1991;19(10):2685-92.
1991: Zuo P; Stanojevic D; Colgan J; Han K; Levine M; Manley J L
Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells.
Genes & development 1991;5(2):254-64.
1990: Takagaki Y; Manley J L; MacDonald C C; Wilusz J; Shenk T
A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs.
Genes & development 1990;4(12A):2112-20.
1990: Harper J E; Miceli S M; Roberts R J; Manley J L
Sequence specificity of the human mRNA N6-adenosine methylase in vitro.
Nucleic acids research 1990;18(19):5735-41.
1990: Read D; Nishigaki T; Manley J L
The Drosophila even-skipped promoter is transcribed in a stage-specific manner in vitro and contains multiple, overlapping factor-binding sites.
Molecular and cellular biology 1990;10(8):4334-44.
1990: Ge H; Manley J L
A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro.
Cell 1990;62(1):25-34.
1990: Ge H; Noble J; Colgan J; Manley J L
Polyoma virus small tumor antigen pre-mRNA splicing requires cooperation between two 3' splice sites.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3338-42.
1990: Wilusz J; Shenk T; Takagaki Y; Manley J L
A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates.
Molecular and cellular biology 1990;10(3):1244-8.
1989: Manley J L; Proudfoot N J; Platt T
RNA 3'-end formation.
Genes & development 1989;3(12B):2218-22.
1989: Rushlow C A; Han K; Manley J L; Levine M
The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila.
Cell 1989;59(6):1165-77.
1989: Connelly S; Manley J L
RNA polymerase II transcription termination is mediated specifically by protein binding to a CCAAT box sequence.
Molecular and cellular biology 1989;9(11):5254-9.
1989: Levine M; Manley J L
Transcriptional repression of eukaryotic promoters.
Cell 1989;59(3):405-8.
1989: Takagaki Y; Ryner L C; Manley J L
Four factors are required for 3'-end cleavage of pre-mRNAs.
Genes & development 1989;3(11):1711-24.
1989: Wu J; Manley J L
Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.
Genes & development 1989;3(10):1553-61.
1989: Ryner L C; Takagaki Y; Manley J L
Multiple forms of poly(A) polymerases purified from HeLa cells function in specific mRNA 3'-end formation.
Molecular and cellular biology 1989;9(10):4229-38.
1989: Pan Z Q; Ge H; Fu X Y; Manley J L; Prives C
Oligonucleotide-targeted degradation of U1 and U2 snRNAs reveals differential interactions of simian virus 40 pre-mRNAs with snRNPs.
Nucleic acids research 1989;17(16):6553-68.
1989: Connelly S; Manley J L
A CCAAT box sequence in the adenovirus major late promoter functions as part of an RNA polymerase II termination signal.
Cell 1989;57(4):561-71.
1989: Noble J C; Ge H; Chaudhuri M; Manley J L
Factor interactions with the simian virus 40 early pre-mRNA influence branch site selection and alternative splicing.
Molecular and cellular biology 1989;9(5):2007-17.
1989: Ryner L C; Takagaki Y; Manley J L
Sequences downstream of AAUAAA signals affect pre-mRNA cleavage and polyadenylation in vitro both directly and indirectly.
Molecular and cellular biology 1989;9(4):1759-71.
1989: Han K; Levine M S; Manley J L
Synergistic activation and repression of transcription by Drosophila homeobox proteins.
Cell 1989;56(4):573-83.
1988: Noble J C; Prives C; Manley J L
Alternative splicing of SV40 early pre-mRNA is determined by branch site selection.
Genes & development 1988;2(11):1460-75.
1988: Fu X Y; Colgan J D; Manley J L
Multiple cis-acting sequence elements are required for efficient splicing of simian virus 40 small-t antigen pre-mRNA.
Molecular and cellular biology 1988;8(9):3582-90.
1988: Manley J L
Polyadenylation of mRNA precursors.
Biochimica et biophysica acta 1988;950(1):1-12.
1988: Connelly S; Manley J L
A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II.
Genes & development 1988;2(4):440-52.
1988: Fu X Y; Ge H; Manley J L
The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3' splice site in alternative splicing.
The EMBO journal 1988;7(3):809-17.
1988: Takagaki Y; Ryner L C; Manley J L
Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation.
Cell 1988;52(5):731-42.
1987: Grass D S; Read D; Lewis E D; Manley J L
Cell- and promoter-specific activation of transcription by DNA replication.
Genes & development 1987;1(10):1065-74.
1987: Noble J C; Pan Z Q; Prives C; Manley J L
Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites.
Cell 1987;50(2):227-36.
1986: Noble J C; Prives C; Manley J L
In vitro splicing of simian virus 40 early pre mRNA.
Nucleic acids research 1986;14(3):1219-35.
1981: Manley J L; Gefter M L
Transcription of mammalian genes in vitro.
Gene amplification and analysis 1981;2():369-82.

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