FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

James Manley

Research Profile

Chemicals & Drugs

Physiology

Anatomy

Co-author Network

Publications

TOP 3
Dafne Campigli Di Giammartino; Yongsheng Shi; James L Manley
PARP1 represses PAP and inhibits polyadenylation during heat shock.
Kehui Xiang; James L Manley; Liang Tong
An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.
Jing-Ping Hsin; James L Manley
The RNA polymerase II CTD coordinates transcription and RNA processing.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of James Manley (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Dafne Campigli Di Giammartino; Yongsheng Shi; James L Manley
PARP1 represses PAP and inhibits polyadenylation during heat shock.
Molecular cell 2013;49(1):7-17.
2012: Kehui Xiang; James L Manley; Liang Tong
An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.
Genes & development 2012;26(20):2265-70.
2012: Jing-Ping Hsin; James L Manley
The RNA polymerase II CTD coordinates transcription and RNA processing.
Genes & development 2012;26(19):2119-37.
2012: Adelene Y Tan; Todd R Riley; Harmen J Bussemaker; Tristan Coady; James L Manley
TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(16):6030-5.
2012: Lynn Biderman; James L Manley; Carol Prives
Mdm2 and MdmX as Regulators of Gene Expression.
Genes & cancer 2012;3(3-4):264-73.
2012: Emanuel Rosonina; Sarah M Duncan; James L Manley
Sumoylation of transcription factor Gcn4 facilitates its Srb10-mediated clearance from promoters in yeast.
Genes & development 2012;26(4):350-5.
2012: Kehui Xiang; James L Manley; Liang Tong
The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity.
Nature communications 2012;3():946.
2011: Jing-Ping Hsin; Amit Sheth; James L Manley
RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing.
Science (New York, N.Y.) 2011;334(6056):683-6.
2011: Takashi Nagaike; James L Manley
Transcriptional activators enhance polyadenylation of mRNA precursors.
RNA biology 2011;8(6):964-7.
2011: Dafne Campigli Di Giammartino; Kensei Nishida; James L Manley
Mechanisms and consequences of alternative polyadenylation.
Molecular cell 2011;43(6):853-66.
2011: Charles J David; Alex R Boyne; Scott R Millhouse; James L Manley
The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex.
Genes & development 2011;25(9):972-83.
2011: Takashi Nagaike; Charlotte Logan; Ikuko Hotta; Orit Rozenblatt-Rosen; Matthew Meyerson; James L Manley
Transcriptional activators enhance polyadenylation of mRNA precursors.
Molecular cell 2011;41(4):409-18.
2011: Yun Bai; Sandeep K Srivastava; Jeong Ho Chang; James L Manley; Liang Tong
Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase.
Molecular cell 2011;41(3):311-20.
2011: Yongsheng Shi; Kensei Nishida; Dafne Campigli Di Giammartino; James L Manley
Heat shock-induced SRSF10 dephosphorylation displays thermotolerance mediated by Hsp27.
Molecular and cellular biology 2011;31(3):458-65.
2010: Mo Chen; Jian Zhang; James L Manley
Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA.
Cancer research 2010;70(22):8977-80.
2010: Charles J David; James L Manley
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged.
Genes & development 2010;24(21):2343-64.
2010: Kehui Xiang; Takashi Nagaike; Song Xiang; TURGAY KILIC; Maia M Beh; James L Manley; Liang Tong
Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature 2010;467(7316):729-33.
2010: Emanuel Rosonina; Sarah M Duncan; James L Manley
SUMO functions in constitutive transcription and during activation of inducible genes in yeast.
Genes & development 2010;24(12):1242-52.
2010: James L Manley; Adrian R Krainer
A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).
Genes & development 2010;24(11):1073-4.
2010: Lisa S Chen; Lei Du-Cuny; Vasupradha Vethantham; David H Hawke; James L Manley; Shuxing Zhang; Varsha Gandhi
Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues.
Biochemical pharmacology 2010;79(5):669-77.
2010: Emanuel Rosonina; James L Manley
Alternative polyadenylation blooms.
Developmental cell 2010;18(2):172-4.
2010: Charles J David; Mo Chen; Marcela Assanah; Peter Canoll; James L Manley
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.
Nature 2010;463(7279):364-8.
2010: Adelene Y Tan; James L Manley
TLS inhibits RNA polymerase III transcription.
Molecular and cellular biology 2010;30(1):186-96.
2009: Adelene Y Tan; James L Manley
The TET family of proteins: functions and roles in disease.
Journal of molecular cell biology 2009;1(2):82-92.
2009: Mo Chen; James L Manley
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches.
Nature reviews. Molecular cell biology 2009;10(11):741-54.
2009: Rachel Beckerman; Aaron J Donner; Melissa Mattia; Melissa J Peart; James L Manley; Joaquin M Espinosa; Carol Prives
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.
Genes & development 2009;23(11):1364-77.
2009: Patricia Richard; James L Manley
Transcription termination by nuclear RNA polymerases.
Genes & development 2009;23(11):1247-69.
2009: Song Xiang; Amalene Cooper-Morgan; Xinfu Jiao; Megerditch Kiledjian; James L Manley; Liang Tong
Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.
Nature 2009;458(7239):784-8.
2009: Ying Feng; Matthew T Valley; Josef Lazar; Allison L Yang; Roderick T Bronson; Stuart Firestein; William A Coetzee; James L Manley
SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart.
Developmental cell 2009;16(4):528-38.
2009: Emanuel Rosonina; Ian M Willis; James L Manley
Sub1 functions in osmoregulation and in transcription by both RNA polymerases II and III.
Molecular and cellular biology 2009;29(8):2308-21.
2009: Yongsheng Shi; Dafne Campigli Di Giammartino; Derek Taylor; Ali Sarkeshik; William J Rice; John R Yates; Joachim Frank; James L Manley
Molecular architecture of the human pre-mRNA 3' processing complex.
Molecular cell 2009;33(3):365-76.
2009: Orit Rozenblatt-Rosen; Takashi Nagaike; Joshua M Francis; Syuzo Kaneko; Karen A Glatt; Christina M Hughes; Thomas LaFramboise; James L Manley; Matthew Meyerson
The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):755-60.
2009: Vasupradha Vethantham; James L Manley
In vitro sumoylation of recombinant proteins and subsequent purification for use in enzymatic assays.
Cold Spring Harbor protocols 2009;2009(1):pdb.prot5121.
2008: Ying Feng; Mo Chen; James L Manley
Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator.
Nature structural & molecular biology 2008;15(10):1040-8.
2008: Vasupradha Vethantham; Nishta Rao; James L Manley
Sumoylation regulates multiple aspects of mammalian poly(A) polymerase function.
Genes & development 2008;22(4):499-511.
2008: Charles J David; James L Manley
The search for alternative splicing regulators: new approaches offer a path to a splicing code.
Genes & development 2008;22(3):279-85.
2008: Stephanie D Bush; Patricia Richard; James L Manley
Variations in intracellular levels of TATA binding protein can affect specific genes by different mechanisms.
Molecular and cellular biology 2008;28(1):83-92.
2007: Yu-Xin Xu; James L Manley
New insights into mitotic chromosome condensation: a role for the prolyl isomerase Pin1.
Cell cycle (Georgetown, Tex.) 2007;6(23):2896-901.
2007: Xialu Li; Tianhui Niu; James L Manley
The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability.
RNA (New York, N.Y.) 2007;13(12):2108-15.
2007: Saba Valadkhan; Afshin Mohammadi; Chaim Wachtel; James L Manley
Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing.
RNA (New York, N.Y.) 2007;13(12):2300-11.
2007: Vasupradha Vethantham; Nishta Rao; James L Manley
Sumoylation modulates the assembly and activity of the pre-mRNA 3' processing complex.
Molecular and cellular biology 2007;27(24):8848-58.
2007: Yu-Xin Xu; James L Manley
Pin1 modulates RNA polymerase II activity during the transcription cycle.
Genes & development 2007;21(22):2950-62.
2007: Syuzo Kaneko; Chun Chu; Aaron J Shatkin; James L Manley
Human capping enzyme promotes formation of transcriptional R loops in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17620-5.
2007: Yongsheng Shi; James L Manley
A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock.
Molecular cell 2007;28(1):79-90.
2007: Denis Lazarev; James L Manley
Concurrent splicing and transcription are not sufficient to enhance splicing efficiency.
RNA (New York, N.Y.) 2007;13(9):1546-57.
2007: Syuzo Kaneko; Orit Rozenblatt-Rosen; Matthew Meyerson; James L Manley
The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination.
Genes & development 2007;21(14):1779-89.
2007: Yu-Xin Xu; James L Manley
The prolyl isomerase Pin1 functions in mitotic chromosome condensation.
Molecular cell 2007;26(2):287-300.
2007: Yun Bai; Thierry C Auperin; Chi-Yuan Chou; Gu-Gang Chang; James L Manley; Liang Tong
Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors.
Molecular cell 2007;25(6):863-75.
2007: Tsuyoshi Kashima; Nishta Rao; James L Manley
An intronic element contributes to splicing repression in spinal muscular atrophy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3426-31.
2006: Corey R Mandel; Syuzo Kaneko; Hailong Zhang; Damara Gebauer; Vasupradha Vethantham; James L Manley; Liang Tong
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease.
Nature 2006;444(7121):953-6.
2006: Yongsheng Shi; Bharat Reddy; James L Manley
PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins.
Molecular cell 2006;23(6):819-29.
2006: Xialu Li; James L Manley
Cotranscriptional processes and their influence on genome stability.
Genes & development 2006;20(14):1838-47.
2006: Xialu Li; James L Manley
Alternative splicing and control of apoptotic DNA fragmentation.
Cell cycle (Georgetown, Tex.) 2006;5(12):1286-8.
2006: Emanuel Rosonina; Syuzo Kaneko; James L Manley
Terminating the transcript: breaking up is hard to do.
Genes & development 2006;20(9):1050-6.
2006: Stephanie Bush; James L Manley
Transcription and RNA processing factors play complex roles in DT40 cells.
Sub-cellular biochemistry 2006;40():207-23.
2005: Xialu Li; James L Manley
New talents for an old acquaintance: the SR protein splicing factor ASF/SF2 functions in the maintenance of genome stability.
Cell cycle (Georgetown, Tex.) 2005;4(12):1706-8.
2005: Xialu Li; Jin Wang; James L Manley
Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation.
Genes & development 2005;19(22):2705-14.
2005: Emanuel Rosonina; James L Manley
From transcription to mRNA: PAF provides a new path.
Molecular cell 2005;20(2):167-8.
2005: Syuzo Kaneko; James L Manley
The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3' end formation.
Molecular cell 2005;20(1):91-103.
2005: Chanseok Shin; Frida E Kleiman; James L Manley
Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins.
Molecular and cellular biology 2005;25(18):8334-43.
2005: Xialu Li; James L Manley
Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability.
Cell 2005;122(3):365-78.
2005: Frida E Kleiman; Foon Wu-Baer; Danae Fonseca; Syuzo Kaneko; Richard Baer; James L Manley
BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.
Genes & development 2005;19(10):1227-37.
2005: Olga Calvo; James L Manley
The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription.
The EMBO journal 2005;24(5):1009-20.
2005: Scott Millhouse; James L Manley
The C-terminal domain of RNA polymerase II functions as a phosphorylation-dependent splicing activator in a heterologous protein.
Molecular and cellular biology 2005;25(2):533-44.
2004: Daron C Barnard; Kevin Ryan; James L Manley; Joel D Richter
Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.
Cell 2004;119(5):641-51.
2004: Chanseok Shin; James L Manley
Cell signalling and the control of pre-mRNA splicing.
Nature reviews. Molecular cell biology 2004;5(9):727-38.
2004: Kevin Ryan; Olga Calvo; James L Manley
Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease.
RNA (New York, N.Y.) 2004;10(4):565-73.
2004: Yu-Xin Xu; James L Manley
Pinning down transcription: regulation of RNA polymerase II activity during the cell cycle.
Cell cycle (Georgetown, Tex.) 2004;3(4):432-5.
2004: Chanseok Shin; Ying Feng; James L Manley
Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock.
Nature 2004;427(6974):553-8.
2003: Yu-Xin Xu; Yutaka Hirose; Xiao Zhen Zhou; Kun Ping Lu; James L Manley
Pin1 modulates the structure and function of human RNA polymerase II.
Genes & development 2003;17(22):2765-76.
2003: Masha V Poyurovsky; Xavier Jacq; Charles Ma; Orit Karni-Schmidt; Peter J Parker; Martin Chalfie; James L Manley; Carol Prives
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization.
Molecular cell 2003;12(4):875-87.
2003: zheng chen; James L Manley
Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates.
Molecular and cellular biology 2003;23(20):7350-62.
2003: zheng chen; James L Manley
In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L.
The Journal of biological chemistry 2003;278(37):35172-83.
2003: Tsuyoshi Kashima; James L Manley
A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy.
Nature genetics 2003;34(4):460-3.
2003: Saba Valadkhan; James L Manley
Characterization of the catalytic activity of U2 and U6 snRNAs.
RNA (New York, N.Y.) 2003;9(7):892-904.
2003: Olga Calvo; James L Manley
Strange bedfellows: polyadenylation factors at the promoter.
Genes & development 2003;17(11):1321-7.
2003: Jayendra Prasad; James L Manley
Regulation and substrate specificity of the SR protein kinase Clk/Sty.
Molecular and cellular biology 2003;23(12):4139-49.
2002: Chanseok Shin; James L Manley
The SR protein SRp38 represses splicing in M phase cells.
Cell 2002;111(3):407-17.
2002: Saba Valadkhan; James L Manley
Intrinsic metal binding by a spliceosomal RNA.
Nature structural biology 2002;9(7):498-9.
2002: Angus Chen; Frida E Kleiman; James L Manley; Toru Ouchi; Zhen-Qiang Pan
Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase.
The Journal of biological chemistry 2002;277(24):22085-92.
2002: Baohe Shen; James L Manley
Pelle kinase is activated by autophosphorylation during Toll signaling in Drosophila.
Development (Cambridge, England) 2002;129(8):1925-33.
2002: Kevin Ryan; Kanneganti G K Murthy; Syuzo Kaneko; James L Manley
Requirements of the RNA polymerase II C-terminal domain for reconstituting pre-mRNA 3' cleavage.
Molecular and cellular biology 2002;22(6):1684-92.
2001: Carol Prives; James L Manley
Why is p53 acetylated?
Cell 2001;107(7):815-8.
2001: Saba Valadkhan; James L Manley
Splicing-related catalysis by protein-free snRNAs.
Nature 2001;413(6857):701-7.
2001: B Shen; H Liu; Edward Y Skolnik; James L Manley
Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8596-601.
2001: Olga Calvo; James L Manley
Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination.
Molecular cell 2001;7(5):1013-23.
2001: M Um; J Yamauchi; S Kato; James L Manley
Heterozygous disruption of the TATA-binding protein gene in DT40 cells causes reduced cdc25B phosphatase expression and delayed mitosis.
Molecular and cellular biology 2001;21(7):2435-48.
2001: Frida E Kleiman; James L Manley
The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression.
Cell 2001;104(5):743-53.
2000: Y Xu; Xiao Tao; B Shen; Tiffany Horng; Ruslan Medzhitov; James L Manley; Liang Tong
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Nature 2000;408(6808):111-5.
2000: Raul Mendez; Kanneganti G K Murthy; Kevin Ryan; James L Manley; Joel D Richter
Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex.
Molecular cell 2000;6(5):1253-9.
2000: Aaron J Shatkin; James L Manley
The ends of the affair: capping and polyadenylation.
Nature structural biology 2000;7(10):838-42.
2000: Gareth Bond; Carol Prives; James L Manley
Poly(A) polymerase phosphorylation is dependent on novel interactions with cyclins.
Molecular and cellular biology 2000;20(14):5310-20.
2000: zheng chen; James L Manley
Robust mRNA transcription in chicken DT40 cells depleted of TAF(II)31 suggests both functional degeneracy and evolutionary divergence.
Molecular and cellular biology 2000;20(14):5064-76.
2000: Y Takagaki; James L Manley
Complex protein interactions within the human polyadenylation machinery identify a novel component.
Molecular and cellular biology 2000;20(5):1515-25.
2000: Saba Valadkhan; James L Manley
A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast.
RNA (New York, N.Y.) 2000;6(2):206-19.
2000: M Um; James L Manley
The Drosophila TATA binding protein contains a strong but masked activation domain.
Gene expression 2000;9(3):123-32.
1999: J Prasad; K Colwill; T Pawson; James L Manley
The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing.
Molecular and cellular biology 1999;19(10):6991-7000.
1999: Frida E Kleiman; James L Manley
Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.
Science (New York, N.Y.) 1999;285(5433):1576-9.
1999: R Tacke; James L Manley
Determinants of SR protein specificity.
Current opinion in cell biology 1999;11(3):358-62.
1999: Yutaka Hirose; R Tacke; James L Manley
Phosphorylated RNA polymerase II stimulates pre-mRNA splicing.
Genes & development 1999;13(10):1234-9.
1999: R Tacke; James L Manley
Functions of SR and Tra2 proteins in pre-mRNA splicing regulation.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1999;220(2):59-63.
1999: C Li; James L Manley
Allosteric regulation of even-skipped repression activity by phosphorylation.
Molecular cell 1999;3(1):77-86.
1998: Y Takagaki; James L Manley
Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation.
Molecular cell 1998;2(6):761-71.
1998: B Shen; James L Manley
Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube.
Development (Cambridge, England) 1998;125(23):4719-28.
1998: SH Xiao; James L Manley
Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2.
The EMBO journal 1998;17(21):6359-67.
1998: Yutaka Hirose; James L Manley
RNA polymerase II is an essential mRNA polyadenylation factor.
Nature 1998;395(6697):93-6.
1998: W Zhao; James L Manley
Deregulation of poly(A) polymerase interferes with cell growth.
Molecular and cellular biology 1998;18(9):5010-20.
1998: Jin Wang; SH Xiao; James L Manley
Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing.
Genes & development 1998;12(14):2222-33.
1998: C Li; James L Manley
Even-skipped represses transcription by binding TATA binding protein and blocking the TFIID-TATA box interaction.
Molecular and cellular biology 1998;18(7):3771-81.
1998: J S Sun; Saba Valadkhan; James L Manley
A UV-crosslinkable interaction in human U6 snRNA.
RNA (New York, N.Y.) 1998;4(5):489-97.
1998: R Tacke; M Tohyama; S Ogawa; James L Manley
Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing.
Cell 1998;93(1):139-48.
1998: D F Colgan; Kanneganti G K Murthy; W Zhao; Carol Prives; James L Manley
Inhibition of poly(A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non-consensus sites.
The EMBO journal 1998;17(4):1053-62.
1998: L Jayaraman; N C Moorthy; Kanneganti G K Murthy; James L Manley; M Bustin; Carol Prives
High mobility group protein-1 (HMG-1) is a unique activator of p53.
Genes & development 1998;12(4):462-72.
1997: Yutaka Hirose; James L Manley
Creatine phosphate, not ATP, is required for 3' end cleavage of mammalian pre-mRNA in vitro.
The Journal of biological chemistry 1997;272(47):29636-42.
1997: D F Colgan; James L Manley
Mechanism and regulation of mRNA polyadenylation.
Genes & development 1997;11(21):2755-66.
1997: JC Dantonel; Kanneganti G K Murthy; James L Manley; Làszlò Tora
Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNA.
Nature 1997;389(6649):399-402.
1997: Y Takagaki; James L Manley
RNA recognition by the human polyadenylation factor CstF.
Molecular and cellular biology 1997;17(7):3907-14.
1997: J S Sun; James L Manley
The human U6 snRNA intramolecular helix: structural constraints and lack of sequence specificity.
RNA (New York, N.Y.) 1997;3(5):514-26.
1997: Jin Wang; James L Manley
Regulation of pre-mRNA splicing in metazoa.
Current opinion in genetics & development 1997;7(2):205-11.
1997: R Tacke; Yang Chen; James L Manley
Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1148-53.
1997: SH Xiao; James L Manley
Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.
Genes & development 1997;11(3):334-44.
1996: James L Manley; Y Takagaki
The end of the message--another link between yeast and mammals.
Science (New York, N.Y.) 1996;274(5292):1481-2.
1996: Y Takagaki; Rebecca Seipelt; Martha L Peterson; James L Manley
The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation.
Cell 1996;87(5):941-52.
1996: D F Colgan; Kanneganti G K Murthy; Carol Prives; James L Manley
Cell-cycle related regulation of poly(A) polymerase by phosphorylation.
Nature 1996;384(6606):282-5.
1996: G Farmer; P Friedlander; J Colgan; James L Manley; Carol Prives
Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein.
Nucleic acids research 1996;24(21):4281-8.
1996: J Wang; Y Takagaki; James L Manley
Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability.
Genes & development 1996;10(20):2588-99.
1996: G Farmer; J Colgan; Y Nakatani; James L Manley; Carol Prives
Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo.
Molecular and cellular biology 1996;16(8):4295-304.
1996: James L Manley; R Tacke
SR proteins and splicing control.
Genes & development 1996;10(13):1569-79.
1996: W Zhao; James L Manley
Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms.
Molecular and cellular biology 1996;16(5):2378-86.
1996: James L Manley; M Um; C Li; H Ashali
Mechanisms of transcriptional activation and repression can both involve TFIID.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1339):517-26.
1996: J L Norris; James L Manley
Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal.
Genes & development 1996;10(7):862-72.
1996: Karen Colwill; Tony Pawson; Brenda Andrews; J Prasad; James L Manley; John C Bell; Peter Duncan
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.
The EMBO journal 1996;15(2):265-75.
1995: Kanneganti G K Murthy; James L Manley
The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation.
Genes & development 1995;9(21):2672-83.
1995: M Um; C Li; James L Manley
The transcriptional repressor even-skipped interacts directly with TATA-binding protein.
Molecular and cellular biology 1995;15(9):5007-16.
1995: S F Jamison; Z Pasman; J Wang; Cindy L Will; Reinhard Lührmann; James L Manley; Mariano A Garcia-Blanco
U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.
Nucleic acids research 1995;23(16):3260-7.
1995: R Tacke; James L Manley
The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.
The EMBO journal 1995;14(14):3540-51.
1995: J Wang; James L Manley
Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways.
RNA (New York, N.Y.) 1995;1(3):335-46.
1995: J Colgan; H Ashali; James L Manley
A direct interaction between a glutamine-rich activator and the N terminus of TFIIB can mediate transcriptional activation in vivo.
Molecular and cellular biology 1995;15(4):2311-20.
1995: J S Sun; James L Manley
A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing.
Genes & development 1995;9(7):843-54.
1995: James L Manley
A complex protein assembly catalyzes polyadenylation of mRNA precursors.
Current opinion in genetics & development 1995;5(2):222-8.
1995: J Colgan; James L Manley
Cooperation between core promoter elements influences transcriptional activity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):1955-9.
1995: James L Manley
Messenger RNA polyadenylylation: a universal modification.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):1800-1.
1995: J L Norris; James L Manley
Regulation of dorsal in cultured cells by Toll and tube: tube function involves a novel mechanism.
Genes & development 1995;9(3):358-69.
1994: Y Takagaki; James L Manley
A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein.
Nature 1994;372(6505):471-4.
1994: T Raabe; Kanneganti G K Murthy; James L Manley
Poly(A) polymerase contains multiple functional domains.
Molecular and cellular biology 1994;14(5):2946-57.
1994: P Zuo; James L Manley
The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3363-7.
1994: J D Kohtz; S F Jamison; Cindy L Will; P Zuo; Reinhard Lührmann; Mariano A Garcia-Blanco; James L Manley
Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors.
Nature 1994;368(6467):119-24.
1994: James L Manley; N J Proudfoot
RNA 3' ends: formation and function--meeting review.
Genes & development 1994;8(3):259-64.
1993: P Zuo; James L Manley
Functional domains of the human splicing factor ASF/SF2.
The EMBO journal 1993;12(12):4727-37.
1993: K Han; James L Manley
Functional domains of the Drosophila Engrailed protein.
The EMBO journal 1993;12(7):2723-33.
1993: A Woppmann; Cindy L Will; U Kornstädt; P Zuo; James L Manley; Reinhard Lührmann
Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.
Nucleic acids research 1993;21(12):2815-22.
1993: J Colgan; S Wampler; James L Manley
Interaction between a transcriptional activator and transcription factor IIB in vivo.
Nature 1993;362(6420):549-53.
1993: K Han; James L Manley
Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain.
Genes & development 1993;7(3):491-503.
1992: D Read; James L Manley
Transcriptional regulators of Drosophila embryogenesis.
Biochimica et biophysica acta 1992;1114(2-3):79-93.
1992: J Wu; James L Manley
Multiple functional domains of human U2 small nuclear RNA: strengthening conserved stem I can block splicing.
Molecular and cellular biology 1992;12(12):5464-73.
1992: Y Takagaki; James L Manley
A human polyadenylation factor is a G protein beta-subunit homologue.
The Journal of biological chemistry 1992;267(33):23471-4.
1992: D Read; Michael Levine; James L Manley
Ectopic expression of the Drosophila tramtrack gene results in multiple embryonic defects, including repression of even-skipped and fushi tarazu.
Mechanisms of development 1992;38(3):183-95.
1992: J L Norris; James L Manley
Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A.
Genes & development 1992;6(9):1654-67.
1992: Kanneganti G K Murthy; James L Manley
Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus.
The Journal of biological chemistry 1992;267(21):14804-11.
1992: D Read; James L Manley
Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities.
The EMBO journal 1992;11(3):1035-44.
1992: Y Takagaki; C C MacDonald; Thomas Shenk; James L Manley
The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1403-7.
1992: J Colgan; James L Manley
TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters.
Genes & development 1992;6(2):304-15.
1991: Y M Han; J Dahlberg; E Lund; James L Manley; Carol Prives
SV40 T-antigen-binding sites within the 5'-flanking regions of human U1 and U2 genes.
Gene 1991;109(2):219-31.
1991: T Raabe; James L Manley
A human homologue of the Escherichia coli DnaJ heat-shock protein.
Nucleic acids research 1991;19(23):6645.
1991: T Raabe; F J Bollum; James L Manley
Primary structure and expression of bovine poly(A) polymerase.
Nature 1991;353(6341):229-34.
1991: J A Wu; James L Manley
Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA.
Nature 1991;352(6338):818-21.
1991: H Ge; P Zuo; James L Manley
Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators.
Cell 1991;66(2):373-82.
1991: Kanneganti G K Murthy; P Park; James L Manley
A nuclear micrococcal-sensitive, ATP-dependent exoribonuclease degrades uncapped but not capped RNA substrates.
Nucleic acids research 1991;19(10):2685-92.
1991: P Zuo; D Stanojević; J Colgan; K Han; Michael Levine; James L Manley
Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells.
Genes & development 1991;5(2):254-64.
1990: Y Takagaki; James L Manley; C C MacDonald; Jeffrey Wilusz; Thomas Shenk
A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs.
Genes & development 1990;4(12A):2112-20.
1990: J E Harper; S M Miceli; R J Roberts; James L Manley
Sequence specificity of the human mRNA N6-adenosine methylase in vitro.
Nucleic acids research 1990;18(19):5735-41.
1990: D Read; T Nishigaki; James L Manley
The Drosophila even-skipped promoter is transcribed in a stage-specific manner in vitro and contains multiple, overlapping factor-binding sites.
Molecular and cellular biology 1990;10(8):4334-44.
1990: H Ge; James L Manley
A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro.
Cell 1990;62(1):25-34.
1990: H Ge; J Noble; J Colgan; James L Manley
Polyoma virus small tumor antigen pre-mRNA splicing requires cooperation between two 3' splice sites.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3338-42.
1990: Jeffrey Wilusz; Thomas Shenk; Y Takagaki; James L Manley
A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates.
Molecular and cellular biology 1990;10(3):1244-8.
1989: C A Rushlow; K Han; James L Manley; Michael Levine
The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila.
Cell 1989;59(6):1165-77.
1989: James L Manley; N J Proudfoot; T Platt
RNA 3'-end formation.
Genes & development 1989;3(12B):2218-22.
1989: Michael Levine; James L Manley
Transcriptional repression of eukaryotic promoters.
Cell 1989;59(3):405-8.
1989: S Connelly; James L Manley
RNA polymerase II transcription termination is mediated specifically by protein binding to a CCAAT box sequence.
Molecular and cellular biology 1989;9(11):5254-9.
1989: Y Takagaki; L C Ryner; James L Manley
Four factors are required for 3'-end cleavage of pre-mRNAs.
Genes & development 1989;3(11):1711-24.
1989: J Wu; James L Manley
Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.
Genes & development 1989;3(10):1553-61.
1989: L C Ryner; Y Takagaki; James L Manley
Multiple forms of poly(A) polymerases purified from HeLa cells function in specific mRNA 3'-end formation.
Molecular and cellular biology 1989;9(10):4229-38.
1989: Z Q Pan; H Ge; X Y Fu; James L Manley; Carol Prives
Oligonucleotide-targeted degradation of U1 and U2 snRNAs reveals differential interactions of simian virus 40 pre-mRNAs with snRNPs.
Nucleic acids research 1989;17(16):6553-68.
1989: S Connelly; James L Manley
A CCAAT box sequence in the adenovirus major late promoter functions as part of an RNA polymerase II termination signal.
Cell 1989;57(4):561-71.
1989: J C Noble; H Ge; M Chaudhuri; James L Manley
Factor interactions with the simian virus 40 early pre-mRNA influence branch site selection and alternative splicing.
Molecular and cellular biology 1989;9(5):2007-17.
1989: L C Ryner; Y Takagaki; James L Manley
Sequences downstream of AAUAAA signals affect pre-mRNA cleavage and polyadenylation in vitro both directly and indirectly.
Molecular and cellular biology 1989;9(4):1759-71.
1989: K Han; M S Levine; James L Manley
Synergistic activation and repression of transcription by Drosophila homeobox proteins.
Cell 1989;56(4):573-83.
1988: J C Noble; Carol Prives; James L Manley
Alternative splicing of SV40 early pre-mRNA is determined by branch site selection.
Genes & development 1988;2(11):1460-75.
1988: X Y Fu; J D Colgan; James L Manley
Multiple cis-acting sequence elements are required for efficient splicing of simian virus 40 small-t antigen pre-mRNA.
Molecular and cellular biology 1988;8(9):3582-90.
1988: James L Manley
Polyadenylation of mRNA precursors.
Biochimica et biophysica acta 1988;950(1):1-12.
1988: S Connelly; James L Manley
A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II.
Genes & development 1988;2(4):440-52.
1988: Y Takagaki; L C Ryner; James L Manley
Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation.
Cell 1988;52(5):731-42.
1988: X Y Fu; H Ge; James L Manley
The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3' splice site in alternative splicing.
The EMBO journal 1988;7(3):809-17.
1987: D S Grass; D Read; E D Lewis; James L Manley
Cell- and promoter-specific activation of transcription by DNA replication.
Genes & development 1987;1(10):1065-74.
1987: J C Noble; Z Q Pan; Carol Prives; James L Manley
Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites.
Cell 1987;50(2):227-36.
1986: J C Noble; Carol Prives; James L Manley
In vitro splicing of simian virus 40 early pre mRNA.
Nucleic acids research 1986;14(3):1219-35.
1981: James L Manley; M L Gefter
Transcription of mammalian genes in vitro.
Gene amplification and analysis 1981;2():369-82.