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Guy Mannaerts

Research Profile

Anatomy

Living Beings

Chemicals & Drugs

Phenomena

Oxidation-Reduction

Concepts & Ideas

Disorders

Zellweger's Syndrome

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Sofie J Huybrechts; Paul P Van Veldhoven; Chantal Brees; Guy P Mannaerts; Georgyi V Los; Marc Fransen
Peroxisome dynamics in cultured mammalian cells.
Erin A Anthonio; Chantal Brees; Eveline Baumgart-Vogt; Tsunaki Hongu; Sofie J Huybrechts; Patrick Van Dijck; Guy P Mannaerts; Yasunori Kanaho; Paul P Van Veldhoven; Marc Fransen
Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6.
Marc Fransen; Leen Amery; Andreas Hartig; Chantal Brees; Anja Rabijns; Guy P Mannaerts; Paul P Van Veldhoven
Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b.

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All Publications

2009: Sofie J Huybrechts; Paul P Van Veldhoven; Chantal Brees; Guy P Mannaerts; Georgyi V Los; Marc Fransen
Peroxisome dynamics in cultured mammalian cells.
Traffic (Copenhagen, Denmark) 2009;10(11):1722-33.
2009: Erin A Anthonio; Chantal Brees; Eveline Baumgart-Vogt; Tsunaki Hongu; Sofie J Huybrechts; Patrick Van Dijck; Guy P Mannaerts; Yasunori Kanaho; Paul P Van Veldhoven; Marc Fransen
Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6.
BMC cell biology 2009;10():58.
2008: Marc Fransen; Leen Amery; Andreas Hartig; Chantal Brees; Anja Rabijns; Guy P Mannaerts; Paul P Van Veldhoven
Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b.
Biochimica et biophysica acta 2008;1783(5):864-73.
2007: Minne Casteels; Mieke Sniekers; P Fraccascia; Guy P Mannaerts; Paul P Van Veldhoven
The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids.
Biochemical Society transactions 2007;35(Pt 5):876-80.
2006: Steven Huyghe; Guy P Mannaerts; Myriam Baes; Paul P Van Veldhoven
Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model.
Biochimica et biophysica acta 2006;1761(9):973-94.
2006: Ilse Vastiau; E A Anthonio; M Brams; Chantal Brees; S G Young; Sam Van de Velde; R J A Wanders; Guy P Mannaerts; Myriam Baes; Paul P Van Veldhoven; Marc Fransen
Farnesylation of Pex19p is not essential for peroxisome biogenesis in yeast and mammalian cells.
Cellular and molecular life sciences : CMLS 2006;63(14):1686-99.
2006: Mieke Sniekers; Veerle Foulon; Guy P Mannaerts; L Van Maldergem; H Mandel; B D Gelb; Minne Casteels; Paul P Van Veldhoven
Thiamine pyrophosphate: an essential cofactor for the alpha-oxidation in mammals--implications for thiamine deficiencies?
Cellular and molecular life sciences : CMLS 2006;63(13):1553-63.
2006: Vasily D Antonenkov; Raija Sormunen; Steffen Ohlmeier; Leen Amery; Marc Fransen; Guy P Mannaerts; J Kalervo Hiltunen
Localization of a portion of the liver isoform of fatty-acid-binding protein (L-FABP) to peroxisomes.
The Biochemical journal 2006;394(Pt 2):475-84.
2005: Veerle Foulon; Mieke Sniekers; Els Huysmans; Stanny Asselberghs; Vincent Mahieu; Guy P Mannaerts; Paul P Van Veldhoven; Minne Casteels
Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids.
The Journal of biological chemistry 2005;280(11):9802-12.
2005: Marc Fransen; Ilse Vastiau; Chantal Brees; Vanessa Brys; Guy P Mannaerts; Paul P Van Veldhoven
Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis.
Journal of molecular biology 2005;346(5):1275-86.
2004: Marc Fransen; Ilse Vastiau; Chantal Brees; Vanessa Brys; Guy P Mannaerts; Paul P Van Veldhoven
Potential role for Pex19p in assembly of PTS-receptor docking complexes.
The Journal of biological chemistry 2004;279(13):12615-24.
2003: Veerle Foulon; Stanny Asselberghs; Wendy Geens; Guy P Mannaerts; Minne Casteels; Paul P Van Veldhoven
Further studies on the substrate spectrum of phytanoyl-CoA hydroxylase: implications for Refsum disease?
Journal of lipid research 2003;44(12):2349-55.
2003: Anneleen Janssen; Pierre Gressens; Markus Grabenbauer; Eveline Baumgart; Arno Schad; Ilse Vanhorebeek; Annelies Brouwers; Peter E Declercq; Dariush Fahimi; Philippe Evrard; Luc Schoonjans; Désiré Collen; Peter Carmeliet; Guy P Mannaerts; Paul P Van Veldhoven; Myriam Baes
Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(30):9732-41.
2003: Minne Casteels; Veerle Foulon; Guy P Mannaerts; Paul P Van Veldhoven
Alpha-oxidation of 3-methyl-substituted fatty acids and its thiamine dependence.
European journal of biochemistry / FEBS 2003;270(8):1619-27.
2003: Veerle Foulon; Minne Casteels; Guy P Mannaerts; Bruce D Gelb; Paul P Van Veldhoven
Thiamine pyrophosphate: an essential cofactor in the mammalian metabolism of 3-methyl-branched fatty acids--implications for thiamine deficiencies?
Advances in experimental medicine and biology 2003;544():305-6.
2002: Karen Ghys; Marc Fransen; Guy P Mannaerts; Paul P Van Veldhoven
Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins.
The Biochemical journal 2002;365(Pt 1):41-50.
2002: Myriam Baes; Pierre Gressens; Steven Huyghe; Nys K De; Chao Qi; Yuzhi Jia; Guy P Mannaerts; Philippe Evrard; Veldhoven P P Van; Peter E Declercq; Janardan K Reddy
The neuronal migration defect in mice with Zellweger syndrome (Pex5 knockout) is not caused by the inactivity of peroxisomal beta-oxidation.
Journal of neuropathology and experimental neurology 2002;61(4):368-74.
2002: Marc Fransen; Chantal Brees; Karen Ghys; Leen Amery; Guy P Mannaerts; Daniel Ladant; Paul P Van Veldhoven
Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay.
Molecular & cellular proteomics : MCP 2002;1(3):243-52.
2001: Leen Amery; Guy P Mannaerts; Suresh Subramani; Paul P Van Veldhoven; Marc Fransen
Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology.
Combinatorial chemistry & high throughput screening 2001;4(7):545-52.
2001: K De Nys; Els Meyhi; Guy P Mannaerts; Marc Fransen; Paul P Van Veldhoven
Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase.
Biochimica et biophysica acta 2001;1533(1):66-72.
2001: Paul P Van Veldhoven; Els Meyhi; Robert H Squires; Marc Fransen; B Fournier; Vanessa Brys; M J Bennett; Guy P Mannaerts
Fibroblast studies documenting a case of peroxisomal 2-methylacyl-CoA racemase deficiency: possible link between racemase deficiency and malabsorption and vitamin K deficiency.
European journal of clinical investigation 2001;31(8):714-22.
2001: Leen Amery; H Sano; Guy P Mannaerts; J Snider; J Van Looy; Marc Fransen; Paul P Van Veldhoven
Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals.
The Biochemical journal 2001;357(Pt 3):635-46.
2001: Marc Fransen; T Wylin; Chantal Brees; Guy P Mannaerts; Paul P Van Veldhoven
Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.
Molecular and cellular biology 2001;21(13):4413-24.
2001: Paul P Van Veldhoven; Minne Casteels; Guy P Mannaerts; Myriam Baes
Further insights into peroxisomal lipid breakdown via alpha- and beta-oxidation.
Biochemical Society transactions 2001;29(Pt 2):292-8.
2001: H Van Houte; E De Hoffmann; Paul P Van Veldhoven; Guy P Mannaerts; Hubert A Carchon; Myriam Baes; Peter E Declercq
Oxidative catabolism of alpha-tocopherol in rat liver microsomes.
Lipids 2001;36(4):367-72.
2001: Steven Huyghe; Minne Casteels; Anneleen Janssen; L Meulders; Guy P Mannaerts; Peter E Declercq; Paul P Van Veldhoven; Myriam Baes
Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse.
The Biochemical journal 2001;353(Pt 3):673-80.
2000: Leen Amery; Marc Fransen; K De Nys; Guy P Mannaerts; Paul P Van Veldhoven
Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans.
Journal of lipid research 2000;41(11):1752-9.
2000: C Causeret; Liesl Geeraert; Gerd Van der Hoeven; Guy P Mannaerts; Paul P Van Veldhoven
Further characterization of rat dihydroceramide desaturase: tissue distribution, subcellular localization, and substrate specificity.
Lipids 2000;35(10):1117-25.
2000: Paul P Van Veldhoven; Sofie Gijsbers; Guy P Mannaerts; J R Vermeesch; Vanessa Brys
Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1).
Biochimica et biophysica acta 2000;1487(2-3):128-34.
2000: Paul P Van Veldhoven; Guy P Mannaerts; Peter E Declercq; Myriam Baes
Do sphingoid bases interact with the peroxisome proliferator activated receptor alpha (PPAR-alpha)?
Cellular signalling 2000;12(7):475-9.
2000: Myriam Baes; Steven Huyghe; Peter Carmeliet; Peter E Declercq; Désiré Collen; Guy P Mannaerts; Paul P Van Veldhoven
Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but also of very long chain fatty acids.
The Journal of biological chemistry 2000;275(21):16329-36.
2000: Vasily D Antonenkov; K Croes; Etienne Waelkens; Paul P Van Veldhoven; Guy P Mannaerts
Identification, purification and characterization of an acetoacetyl-CoA thiolase from rat liver peroxisomes.
European journal of biochemistry / FEBS 2000;267(10):2981-90.
2000: K Croes; Veerle Foulon; Minne Casteels; Paul P Van Veldhoven; Guy P Mannaerts
Phytanoyl-CoA hydroxylase: recognition of 3-methyl-branched acyl-coAs and requirement for GTP or ATP and Mg(2+) in addition to its known hydroxylation cofactors.
Journal of lipid research 2000;41(4):629-36.
2000: Vasily D Antonenkov; Paul P Van Veldhoven; Guy P Mannaerts
Isolation and subunit composition of native sterol carrier protein 2/3-oxoacyl-coenzyme A thiolase from normal rat liver peroxisomes.
Protein expression and purification 2000;18(3):249-56.
2000: Guy P Mannaerts; Paul P Van Veldhoven; Minne Casteels
Peroxisomal lipid degradation via beta- and alpha-oxidation in mammals.
Cell biochemistry and biophysics 2000;32 Spring():73-87.
2000: Anneleen Janssen; Myriam Baes; Pierre Gressens; Guy P Mannaerts; Peter E Declercq; Paul P Van Veldhoven
Docosahexaenoic acid deficit is not a major pathogenic factor in peroxisome-deficient mice.
Laboratory investigation; a journal of technical methods and pathology 2000;80(1):31-5.
1999: Veerle Foulon; Vasily D Antonenkov; K Croes; Etienne Waelkens; Guy P Mannaerts; Paul P Van Veldhoven; Minne Casteels
Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10039-44.
1999: Sofie Gijsbers; Guy P Mannaerts; Bernard Himpens; Paul P Van Veldhoven
N-acetyl-sphingenine-1-phosphate is a potent calcium mobilizing agent.
FEBS letters 1999;453(3):269-72.
1999: K Croes; Minne Casteels; M Dieuaide-Noubhani; Guy P Mannaerts; Paul P Van Veldhoven
Stereochemistry of the alpha-oxidation of 3-methyl-branched fatty acids in rat liver.
Journal of lipid research 1999;40(4):601-9.
1999: Vasily D Antonenkov; Paul P Van Veldhoven; Etienne Waelkens; Guy P Mannaerts
Comparison of the stability and substrate specificity of purified peroxisomal 3-oxoacyl-CoA thiolases A and B from rat liver.
Biochimica et biophysica acta 1999;1437(2):136-41.
1999: Vasily D Antonenkov; Paul P Van Veldhoven; Guy P Mannaerts
The commonly used Mg2+-enolate assay can lead to underestimation of thiolase activity.
Analytical biochemistry 1999;267(2):418-20.
1999: Paul P Van Veldhoven; Guy P Mannaerts; Minne Casteels; K Croes
Hepatic alpha-oxidation of phytanic acid. A revised pathway.
Advances in experimental medicine and biology 1999;466():273-81.
1999: Paul P Van Veldhoven; Guy P Mannaerts
Role and organization of peroxisomal beta-oxidation.
Advances in experimental medicine and biology 1999;466():261-72.
1999: K Croes; Paul P Van Veldhoven; Guy P Mannaerts; Minne Casteels
Alpha-oxidation of 3-methyl-branched fatty acids: a revised pathway confined to peroxisomes.
Lipids 1999;34 Suppl():S159.
1999: Vasily D Antonenkov; Paul P Van Veldhoven; Guy P Mannaerts
The growing family of peroxisomal thiolases.
Lipids 1999;34 Suppl():S157.
1998: T Wylin; Myriam Baes; Chantal Brees; Guy P Mannaerts; Marc Fransen; Paul P Van Veldhoven
Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii.
European journal of biochemistry / FEBS 1998;258(2):332-8.
1998: Leen Amery; Chantal Brees; Myriam Baes; Chiaki Setoyama; Retsu Miura; Guy P Mannaerts; Paul P Van Veldhoven
C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal.
The Biochemical journal 1998;336 ( Pt 2)():367-71.
1998: H Stier; H Dariush Fahimi; Paul P Van Veldhoven; Guy P Mannaerts; Alfred Völkl; Eveline Baumgart
Maturation of peroxisomes in differentiating human hepatoblastoma cells (HepG2): possible involvement of the peroxisome proliferator-activated receptor alpha (PPAR alpha).
Differentiation; research in biological diversity 1998;64(1):55-66.
1998: Paul P Van Veldhoven; Els Meyhi; Guy P Mannaerts
Enzymatic quantitation of cholesterol esters in lipid extracts.
Analytical biochemistry 1998;258(1):152-5.
1997: Vasily D Antonenkov; Paul P Van Veldhoven; Etienne Waelkens; Guy P Mannaerts
Substrate specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates.
The Journal of biological chemistry 1997;272(41):26023-31.
1997: Liesl Geeraert; Guy P Mannaerts; Paul P Van Veldhoven
Conversion of dihydroceramide into ceramide: involvement of a desaturase.
The Biochemical journal 1997;327 ( Pt 1)():125-32.
1997: Minne Casteels; K Croes; Paul P Van Veldhoven; Guy P Mannaerts
Peroxisomal localization of alpha-oxidation in human liver.
Journal of inherited metabolic disease 1997;20(5):665-73.
1997: Myriam Baes; Pierre Gressens; Eveline Baumgart; Peter Carmeliet; Minne Casteels; Marc Fransen; Philippe Evrard; Dariush Fahimi; Peter E Declercq; Désiré Collen; Paul P Van Veldhoven; Guy P Mannaerts
A mouse model for Zellweger syndrome.
Nature genetics 1997;17(1):49-57.
1997: K Croes; Minne Casteels; Stanny Asselberghs; Piet Herdewijn; Guy P Mannaerts; Paul P Van Veldhoven
Formation of a 2-methyl-branched fatty aldehyde during peroxisomal alpha-oxidation.
FEBS letters 1997;412(3):643-5.
1997: J C Vanhooren; Peter Marynen; Guy P Mannaerts; Paul P Van Veldhoven
Evidence for the existence of a pristanoyl-CoA oxidase gene in man.
The Biochemical journal 1997;325 ( Pt 3)():593-9.
1997: M Dieuaide-Noubhani; Stanny Asselberghs; Guy P Mannaerts; Paul P Van Veldhoven
Evidence that multifunctional protein 2, and not multifunctional protein 1, is involved in the peroxisomal beta-oxidation of pristanic acid.
The Biochemical journal 1997;325 ( Pt 2)():367-73.
1997: H A Van Houte; Paul P Van Veldhoven; Guy P Mannaerts; Myriam Baes; Peter E Declercq
Metabolism of dolichol, dolichoic acid and nordolichoic acid in cultured cells.
Biochimica et biophysica acta 1997;1347(1):93-100.
1997: Paul P Van Veldhoven; K Croes; Minne Casteels; Guy P Mannaerts
2-methylacyl racemase: a coupled assay based on the use of pristanoyl-CoA oxidase/peroxidase and reinvestigation of its subcellular distribution in rat and human liver.
Biochimica et biophysica acta 1997;1347(1):62-8.
1997: D Novikov; M Dieuaide-Noubhani; J R Vermeesch; B Fournier; Guy P Mannaerts; Paul P Van Veldhoven
The human peroxisomal multifunctional protein involved in bile acid synthesis: activity measurement, deficiency in Zellweger syndrome and chromosome mapping.
Biochimica et biophysica acta 1997;1360(3):229-40.
1997: K Croes; Paul P Van Veldhoven; Guy P Mannaerts; Minne Casteels
Production of formyl-CoA during peroxisomal alpha-oxidation of 3-methyl-branched fatty acids.
FEBS letters 1997;407(2):197-200.
1997: M Dieuaide-Noubhani; D Novikov; Joël Vandekerckhove; P P Veldhoven; Guy P Mannaerts
Identification and characterization of the 2-enoyl-CoA hydratases involved in peroxisomal beta-oxidation in rat liver.
The Biochemical journal 1997;321 ( Pt 1)():253-9.
1996: K Croes; Minne Casteels; Paul P Van Veldhoven; Guy P Mannaerts
Alpha-oxidation in intact and permeabilized rat hepatocytes.
Annals of the New York Academy of Sciences 1996;804():682-3.
1996: M Dieuaide; D K Novikov; Hubert A Carchon; Paul P Van Veldhoven; Guy P Mannaerts
Substrate stereospecificities of rat liver peroxisomal 3-hydroxyacyl-CoA dehydrogenases.
Annals of the New York Academy of Sciences 1996;804():680-1.
1996: E Baumgart; J C Vanhooren; Marc Fransen; Guy P Mannaerts; Paul P Van Veldhoven
Mammalian peroxisomal acyl-CoA oxidases. III. Molecular characterization of human branched chain fatty acyl-CoA oxidase.
Annals of the New York Academy of Sciences 1996;804():678-9.
1996: E Baumgart; J C Vanhooren; Marc Fransen; Paul P Van Veldhoven; Guy P Mannaerts
Mammalian peroxisomal acyl-CoA oxidases. II. Molecular characterization of rat trihydroxycoprostanoyl-CoA oxidase.
Annals of the New York Academy of Sciences 1996;804():676-7.
1996: J C Vanhooren; E Baumgart; Marc Fransen; Guy P Mannaerts; Paul P Van Veldhoven
Mammalian peroxisomal acyl-CoA oxidases. I. Molecular characterization of rat pristanoyl-CoA oxidase.
Annals of the New York Academy of Sciences 1996;804():674-5.
1996: Marc Fransen; Peter Marynen; E Baumgart; J C Vanhooren; Guy P Mannaerts; Paul P Van Veldhoven
Further characterization of the human peroxisomal C-terminal targeting signal protein import receptor.
Annals of the New York Academy of Sciences 1996;804():672-3.
1996: Guy P Mannaerts; Paul P Van Veldhoven
Functions and organization of peroxisomal beta-oxidation.
Annals of the New York Academy of Sciences 1996;804():99-115.
1996: E Baumgart; J C Vanhooren; Marc Fransen; Peter Marynen; M Puype; J Vandekerckhove; Jack Leunissen; H D Fahimi; Guy P Mannaerts; Paul P Van Veldhoven
Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13748-53.
1996: E Baumgart; J C Vanhooren; Marc Fransen; Fred Van Leuven; H D Fahimi; Paul P Van Veldhoven; Guy P Mannaerts
Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase.
The Biochemical journal 1996;320 ( Pt 1)():115-21.
1996: Marc Fransen; Chantal Brees; Paul P Van Veldhoven; Guy P Mannaerts
The visualization of peroxisomal proteins containing a C-terminal targeting sequence on western blot by using the biotinylated PTS1-receptor.
Analytical biochemistry 1996;242(1):26-30.
1996: Paul P Van Veldhoven; Stanny Asselberghs; H J Eyssen; Guy P Mannaerts
Stabilisation and partial purification of Triton X-100 solubilised trihydroxycoprostanoyl-CoA synthetase from rat liver.
Biochemistry and molecular biology international 1996;40(3):447-57.
1996: Ben Distel; Ralf Erdmann; Stephen J Gould; Günter Blobel; D I Crane; James M Cregg; Gabriele Dodt; Y Fujiki; J M Goodman; W W Just; Jan A K W Kiel; Wolf-H Kunau; Paul B LAZAROW; Guy P Mannaerts; Hugo W Moser; T Osumi; R A Rachubinski; A Roscher; Suresh Subramani; Henk F Tabak; T Tsukamoto; David Valle; Ida Van der klei; P P van Veldhoven; M Veenhuis
A unified nomenclature for peroxisome biogenesis factors.
The Journal of cell biology 1996;135(1):1-3.
1996: K Croes; Minne Casteels; E De Hoffmann; Guy P Mannaerts; Paul P Van Veldhoven
alpha-Oxidation of 3-methyl-substituted fatty acids in rat liver. Production of formic acid instead of CO2, cofactor requirements, subcellular localization and formation of a 2-hydroxy-3-methylacyl-CoA intermediate.
European journal of biochemistry / FEBS 1996;240(3):674-83.
1996: M Dieuaide-Noubhani; D Novikov; E Baumgart; J C Vanhooren; Marc Fransen; M Goethals; J Vandekerckhove; Paul P Van Veldhoven; Guy P Mannaerts
Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver. Relationship between the different dehydrogenases and evidence that fatty acids and the C27 bile acids di- and tri-hydroxycoprostanic acids are metabolized by separate multifunctional proteins.
European journal of biochemistry / FEBS 1996;240(3):660-6.
1996: J C Vanhooren; Marc Fransen; B de Béthune; E Baumgart; Myriam Baes; S Torrekens; Fred Van Leuven; Guy P Mannaerts; Paul P Van Veldhoven
Rat pristanoyl-CoA oxidase. cDNA cloning and recognition of its C-terminal (SQL) by the peroxisomal-targeting signal 1 receptor.
European journal of biochemistry / FEBS 1996;239(2):302-9.
1996: Paul P Van Veldhoven; K Croes; Stanny Asselberghs; P Herdewijn; Guy P Mannaerts
Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase.
FEBS letters 1996;388(1):80-4.
1996: Paul P Van Veldhoven; E Baumgart; Guy P Mannaerts
Iodixanol (Optiprep), an improved density gradient medium for the iso-osmotic isolation of rat liver peroxisomes.
Analytical biochemistry 1996;237(1):17-23.
1995: Peter Marynen; Marc Fransen; Petra Raeymaekers; Guy P Mannaerts; Paul P Van Veldhoven
The gene for the peroxisomal targeting signal import receptor (PXR1) is located on human chromosome 12p13, flanked by TPI1 and D12S1089.
Genomics 1995;30(2):366-8.
1995: P De Ceuster; Guy P Mannaerts; Paul P Van Veldhoven
Identification and subcellular localization of sphinganine-phosphatases in rat liver.
The Biochemical journal 1995;311 ( Pt 1)():139-46.
1995: Marc Fransen; Chantal Brees; E Baumgart; J C Vanhooren; Myriam Baes; Guy P Mannaerts; Paul P Van Veldhoven
Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor.
The Journal of biological chemistry 1995;270(13):7731-6.
1995: K Croes; Minne Casteels; Paul P Van Veldhoven; Guy P Mannaerts
Evidence for the importance of iron in the alpha-oxidation of 3-methyl-substituted fatty acids in the intact cell.
Biochimica et biophysica acta 1995;1255(1):63-7.
1994: Minne Casteels; K Croes; Paul P Van Veldhoven; Guy P Mannaerts
Aminotriazole is a potent inhibitor of alpha-oxidation of 3-methyl-substituted fatty acids in rat liver.
Biochemical pharmacology 1994;48(10):1973-5.
1994: Paul P Van Veldhoven; P Van Rompuy; J C Vanhooren; Guy P Mannaerts
Purification and further characterization of peroxisomal trihydroxycoprostanoyl-CoA oxidase from rat liver.
The Biochemical journal 1994;304 ( Pt 1)():195-200.
1994: Marc Fransen; Chantal Brees; B de Béthune; Paul P Van Veldhoven; Guy P Mannaerts
The 80 kDa cytosolic protein that binds the C-terminal part of rat acyl-CoA oxidase is not a peroxisomal import receptor but a prolyl-endopeptidase.
Biochimica et biophysica acta 1994;1201(2):157-64.
1994: D K Novikov; G F Vanhove; Hubert A Carchon; Stanny Asselberghs; H J Eyssen; Paul P Van Veldhoven; Guy P Mannaerts
Peroxisomal beta-oxidation. Purification of four novel 3-hydroxyacyl-CoA dehydrogenases from rat liver peroxisomes.
The Journal of biological chemistry 1994;269(43):27125-35.
1994: H Castelein; T Gulick; Peter E Declercq; Guy P Mannaerts; David D Moore; Myriam Baes
The peroxisome proliferator activated receptor regulates malic enzyme gene expression.
The Journal of biological chemistry 1994;269(43):26754-8.
1994: S Huang; Paul P Van Veldhoven; Stanny Asselberghs; H J Eyssen; E de Hoffmann; Guy P Mannaerts
Comparison of fatty acid alpha-oxidation by rat hepatocytes and by liver microsomes fortified with NADPH, Fe3+ and phosphate.
Lipids 1994;29(10):671-8.
1994: J C Vanhooren; Stanny Asselberghs; H J Eyssen; Guy P Mannaerts; Paul P Van Veldhoven
Activation of 3-methyl-branched fatty acids in rat liver.
The International journal of biochemistry 1994;26(9):1095-101.
1994: Paul P Van Veldhoven; P De Ceuster; R Rozenberg; Guy P Mannaerts; E de Hoffmann
On the presence of phosphorylated sphingoid bases in rat tissues. A mass-spectrometric approach.
FEBS letters 1994;350(1):91-5.
1994: Paul P Van Veldhoven; P Van Rompuy; Marc Fransen; B De Béthune; Guy P Mannaerts
Large-scale purification and further characterization of rat pristanoyl-CoA oxidase.
European journal of biochemistry / FEBS 1994;222(3):795-801.
1994: Paul P Van Veldhoven; Guy P Mannaerts
Assembly of the peroxisomal membrane.
Sub-cellular biochemistry 1994;22():231-61.
1993: H Castelein; Peter E Declercq; Guy P Mannaerts; Myriam Baes
Peroxisome proliferators and T3 operate by way of distinct receptors.
FEBS letters 1993;332(1-2):24-6.
1993: G G Parmentier; Roger Busson; G A Janssen; Guy P Mannaerts; H J Eyssen
Synthesis and 29-14C-labeling of 3 alpha, 7 alpha, 12 alpha-trihydroxy-27-carboxymethyl-5 beta-cholestan-26-oic acid. A bile acid occurring in peroxisomal diseases.
Steroids 1993;58(8):351-6.
1993: G J Sulter; K Verheyden; Guy P Mannaerts; W Harder; Marten Veenhuis
The in vitro permeability of yeast peroxisomal membranes is caused by a 31 kDa integral membrane protein.
Yeast (Chichester, England) 1993;9(7):733-42.
1993: G Vanhove; Paul P Van Veldhoven; H J Eyssen; Guy P Mannaerts
Mitochondrial short-chain acyl-CoA dehydrogenase of human liver and kidney can function as an oxidase.
The Biochemical journal 1993;292 ( Pt 1)():23-30.
1993: G F Vanhove; Paul P Van Veldhoven; Marc Fransen; S Denis; H J Eyssen; R J Wanders; Guy P Mannaerts
The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney.
The Journal of biological chemistry 1993;268(14):10335-44.
1993: Guy P Mannaerts; Paul P Van Veldhoven
Metabolic pathways in mammalian peroxisomes.
Biochimie 1993;75(3-4):147-58.
1993: Guy P Mannaerts; Paul P Van Veldhoven
[Peroxisomal beta-oxidation].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1993;55(1):45-78.
1992: Paul P Van Veldhoven; G Vanhove; S Assselberghs; H J Eyssen; Guy P Mannaerts
Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase.
The Journal of biological chemistry 1992;267(28):20065-74.
1992: Guy P Mannaerts; Paul P Van Veldhoven
Role of peroxisomes in mammalian metabolism.
Cell biochemistry and function 1992;10(3):141-51.
1992: K Verheyden; Marc Fransen; Paul P Van Veldhoven; Guy P Mannaerts
Presence of small GTP-binding proteins in the peroxisomal membrane.
Biochimica et biophysica acta 1992;1109(1):48-54.
1992: S Huang; Paul P Van Veldhoven; F Vanhoutte; G Parmentier; H J Eyssen; Guy P Mannaerts
Alpha-oxidation of 3-methyl-substituted fatty acids in rat liver.
Archives of biochemistry and biophysics 1992;296(1):214-23.
1992: H K Stals; Guy P Mannaerts; Peter E Declercq
Factors influencing triacylglycerol synthesis in permeabilized rat hepatocytes.
The Biochemical journal 1992;283 ( Pt 3)():719-25.
1991: G Vanhove; Paul P Van Veldhoven; F Vanhoutte; G Parmentier; H J Eyssen; Guy P Mannaerts
Mitochondrial and peroxisomal beta oxidation of the branched chain fatty acid 2-methylpalmitate in rat liver.
The Journal of biological chemistry 1991;266(36):24670-5.
1991: Paul P Van Veldhoven; G Vanhove; F Vanhoutte; G Dacremont; G Parmentier; H J Eyssen; Guy P Mannaerts
Identification and purification of a peroxisomal branched chain fatty acyl-CoA oxidase.
The Journal of biological chemistry 1991;266(36):24676-83.
1991: R J Wanders; Minne Casteels; Guy P Mannaerts; Carlo W T van Roermund; R B Schutgens; Viktor Kozich; Jirí Zeman; J Hyanek
Accumulation and impaired in vivo metabolism of di- and trihydroxycholestanoic acid in two patients.
Clinica chimica acta; international journal of clinical chemistry 1991;202(3):123-32.
1991: Paul P Van Veldhoven; Chantal Brees; Guy P Mannaerts
D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man.
Biochimica et biophysica acta 1991;1073(1):203-8.
1991: R J Wanders; Carlo W T van Roermund; A Schelen; R B Schutgens; Jirí Zeman; Viktor Kozich; J Hyanek; Minne Casteels; Guy P Mannaerts
Di- and trihydroxycholestanaemia in twin sisters.
Journal of inherited metabolic disease 1991;14(3):357-60.
1990: Minne Casteels; L Schepers; Paul P Van Veldhoven; H J Eyssen; Guy P Mannaerts
Separate peroxisomal oxidases for fatty acyl-CoAs and trihydroxycoprostanoyl-CoA in human liver.
Journal of lipid research 1990;31(10):1865-72.
1990: Minne Casteels; L Schepers; Paul P Van Veldhoven; Guy P Mannaerts
Separate peroxisomal acyl-CoA oxidases for fatty acids and trihydroxycoprostanic acid in human liver.
Biochemical Society transactions 1990;18(5):1003-4.
1990: L Schepers; Paul P Van Veldhoven; Minne Casteels; H J Eyssen; Guy P Mannaerts
Presence of three acyl-CoA oxidases in rat liver peroxisomes. An inducible fatty acyl-CoA oxidase, a noninducible fatty acyl-CoA oxidase, and a noninducible trihydroxycoprostanoyl-CoA oxidase.
The Journal of biological chemistry 1990;265(9):5242-6.
1990: Guy P Mannaerts; Paul P Van Veldhoven
The peroxisome: functional properties in health and disease.
Biochemical Society transactions 1990;18(1):87-9.
1990: A C Douma; Marten Veenhuis; G J Sulter; H R Waterham; K Verheyden; Guy P Mannaerts; W Harder
Permeability properties of peroxisomal membranes from yeasts.
Archives of microbiology 1990;153(5):490-5.
1990: H Przyrembel; R J Wanders; Carlo W T van Roermund; R B Schutgens; Guy P Mannaerts; Minne Casteels
Di- and trihydroxycholestanoic acidaemia with hepatic failure.
Journal of inherited metabolic disease 1990;13(3):367-70.
1989: L Schepers; Paul P Van Veldhoven; H J Eyssen; Guy P Mannaerts
Separate peroxisomal oxidases for long-chain acyl-CoA and trihydroxycoprostanoyl-CoA.
Biochemical Society transactions 1989;17(6):1076.
1989: M Lemmens; K Verheyden; Paul P Van Veldhoven; J Vereecke; Guy P Mannaerts; Edward Carmeliet
Single-channel analysis of a large conductance channel in peroxisomes from rat liver.
Biochimica et biophysica acta 1989;984(3):351-9.
1989: Minne Casteels; L Schepers; G Parmentier; H J Eyssen; Guy P Mannaerts
Activation and peroxisomal beta-oxidation of fatty acids and bile acid intermediates in liver from Bombina orientalis and from the rat.
Comparative biochemistry and physiology. B, Comparative biochemistry 1989;92(1):129-32.
1989: Minne Casteels; Carlo W T van Roermund; L Schepers; L Govaert; H J Eyssen; Guy P Mannaerts; R J Wanders
Deficient oxidation of trihydroxycoprostanic acid in liver homogenates from patients with peroxisomal diseases.
Journal of inherited metabolic disease 1989;12(4):415-22.
1989: L Schepers; Minne Casteels; K Verheyden; G Parmentier; Stanny Asselberghs; H J Eyssen; Guy P Mannaerts
Subcellular distribution and characteristics of trihydroxycoprostanoyl-CoA synthetase in rat liver.
The Biochemical journal 1989;257(1):221-9.
1988: Minne Casteels; L Schepers; Johan Van Eldere; H J Eyssen; Guy P Mannaerts
Inhibition of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid oxidation and of bile acid secretion in rat liver by fatty acids.
The Journal of biological chemistry 1988;263(10):4654-61.
1988: L Schepers; Minne Casteels; Joseph Vamecq; G Parmentier; Paul P Van Veldhoven; Guy P Mannaerts
Beta-oxidation of the carboxyl side chain of prostaglandin E2 in rat liver peroxisomes and mitochondria.
The Journal of biological chemistry 1988;263(6):2724-31.
1988: F D Suyatna; Paul P Van Veldhoven; Marcel Borgers; Guy P Mannaerts
Phospholipid composition and amphiphile content of isolated sarcolemma from normal and autolytic rat myocardium.
Journal of molecular and cellular cardiology 1988;20(1):47-62.
1987: Joseph Vamecq; L Schepers; G Parmentier; Guy P Mannaerts
Inhibition of peroxisomal fatty acyl-CoA oxidase by antimycin A.
The Biochemical journal 1987;248(2):603-7.