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Bengt Mannervik

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TOP 3
Usama M Hegazy; Yaman Musdal; Bengt Mannervik
Hidden allostery in human glutathione transferase p1-1 unveiled by unnatural amino Acid substitutions and inhibition studies.
Wei Zhang; Bengt Mannervik
An improved dual-tube megaprimer approach for multi-site saturation mutagenesis.
Song Sun; Wei Zhang; Bengt Mannervik; Dan I Andersson
Evolution of broad spectrum β-lactam resistance in an engineered metallo-β-lactamase.

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All Publications

2013: Usama M Hegazy; Yaman Musdal; Bengt Mannervik
Hidden allostery in human glutathione transferase p1-1 unveiled by unnatural amino Acid substitutions and inhibition studies.
Journal of molecular biology 2013;425(9):1509-14.
2013: Wei Zhang; Bengt Mannervik
An improved dual-tube megaprimer approach for multi-site saturation mutagenesis.
World journal of microbiology & biotechnology 2013;29(4):667-72.
2013: Song Sun; Wei Zhang; Bengt Mannervik; Dan I Andersson
Evolution of broad spectrum β-lactam resistance in an engineered metallo-β-lactamase.
The Journal of biological chemistry 2013;288(4):2314-24.
2012: Mika Ito; Yoshihiro Ito; Kyoko Kojima-Aikawa; Bengt Mannervik; Ralf Morgenstern; Yukiko Nakano; Yasushi Sako; Aya Shibata; Satoshi Shuto; Jie Zhang; Michio Hiroshima; Hiroshi Abe
Universal caging group for the in-cell detection of glutathione transferase applied to 19F NMR and bioluminogenic probes.
Chembiochem : a European journal of chemical biology 2012;13(10):1428-32.
2012: Wei Zhang; Maria João Ramos; Daniel F A R Dourado; Pedro Alexandrino Fernandes; Bengt Mannervik
Multidimensional epistasis and fitness landscapes in enzyme evolution.
The Biochemical journal 2012;445(1):39-46.
2012: Olof Modén; Wei Zhang; Bengt Mannervik
Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine.
Protein engineering, design & selection : PEDS 2012;25(4):189-97.
2012: Wei Zhang; Olof Modén; Kaspars Tars; Bengt Mannervik
Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine.
Chemistry & biology 2012;19(3):414-21.
2012: Bengt Mannervik
Five decades with glutathione and the GSTome.
The Journal of biological chemistry 2012;287(9):6072-83.
2011: P David Josephy; Dan Pan; Michael D Ianni; Bengt Mannervik
Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface.
Archives of biochemistry and biophysics 2011;513(2):87-93.
2011: Malena A Norrgård; Bengt Mannervik
Engineering GST M2-2 for high activity with indene 1,2-oxide and indication of an H-site residue sustaining catalytic promiscuity.
Journal of molecular biology 2011;412(1):111-20.
2011: Jie Zhang; Aya Shibata; Satoshi Shuto; Hiroshi Abe; Mika Ito; Yoshihiro Ito; Bengt Mannervik; Ralf Morgenstern
Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy.
Journal of the American Chemical Society 2011;133(35):14109-19.
2011: Natalia Fedulova; Bengt Mannervik
Experimental conditions affecting functional comparison of highly active glutathione transferases.
Analytical biochemistry 2011;413(1):16-23.
2011: Malena A Norrgård; Ulf Hellman; Bengt Mannervik
Cys-X scanning for expansion of active-site residues and modulation of catalytic functions in a glutathione transferase.
The Journal of biological chemistry 2011;286(19):16871-8.
2011: Emilia Larsson; Bengt Mannervik; Françoise Raffalli-Mathieu
Quantitative and selective polymerase chain reaction analysis of highly similar human alpha-class glutathione transferases.
Analytical biochemistry 2011;412(1):96-101.
2011: Natalia Fedulova; Françoise Raffalli-Mathieu; Bengt Mannervik
Characterization of porcine alpha-class glutathione transferase A1-1.
Archives of biochemistry and biophysics 2011;507(2):205-11.
2011: Asa Brunnström; Mats Hamberg; William J Griffiths; Bengt Mannervik; Hans-Erik Claesson
Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils.
Lipids 2011;46(1):69-79.
2010: Natalia Fedulova; Françoise Raffalli-Mathieu; Bengt Mannervik
Porcine glutathione transferase Alpha 2-2 is a human GST A3-3 analogue that catalyses steroid double-bond isomerization.
The Biochemical journal 2010;431(1):159-67.
2010: Arna Runarsdottir; Bengt Mannervik
A novel quasi-species of glutathione transferase with high activity towards naturally occurring isothiocyanates evolves from promiscuous low-activity variants.
Journal of molecular biology 2010;401(3):451-64.
2010: Wei Zhang; Olof Modén; Bengt Mannervik
Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine.
Chemico-biological interactions 2010;186(2):110-7.
2010: Bengt Mannervik; Arna Runarsdottir
The quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution.
FEBS letters 2010;584(12):2565-71.
2010: Anna-Karin Larsson; Abeer Shokeer; Bengt Mannervik
Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents.
Archives of biochemistry and biophysics 2010;497(1-2):28-34.
2010: Abeer Shokeer; Bengt Mannervik
Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1.
Biochimica et biophysica acta 2010;1800(4):466-73.
2010: Kaspars Tars; Birgit Olin; Bengt Mannervik
Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases.
Journal of molecular biology 2010;397(1):332-40.
2010: Larissa M Balogh; Isolde Le Trong; Kimberly A Kripps; Laura M Shireman; Ronald E Stenkamp; Wei Zhang; Bengt Mannervik; William M Atkins
Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal.
Biochemistry 2010;49(7):1541-8.
2010: Abeer Shokeer; Bengt Mannervik
Minor modifications of the C-terminal helix reschedule the favored chemical reactions catalyzed by theta class glutathione transferase T1-1.
The Journal of biological chemistry 2010;285(8):5639-45.
2010: Daniel F A R Dourado; Pedro Alexandrino Fernandes; Bengt Mannervik; Maria João Ramos
Glutathione transferase A1-1: catalytic importance of arginine 15.
The journal of physical chemistry. B 2010;114(4):1690-7.
2009: Sanela Kurtovic; Bengt Mannervik
Identification of emerging quasi-species in directed enzyme evolution.
Biochemistry 2009;48(40):9330-9.
2009: P David Josephy; Meredith Kent; Bengt Mannervik
Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties.
Archives of biochemistry and biophysics 2009;490(1):24-9.
2009: Larissa M Balogh; Isolde Le Trong; Kimberly A Kripps; Kaspars Tars; Ronald E Stenkamp; Bengt Mannervik; William M Atkins
Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals.
Biochemistry 2009;48(32):7698-704.
2009: Bengt Mannervik; Arna Runarsdottir; Sanela Kurtovic
Multi-substrate-activity space and quasi-species in enzyme evolution: Ohno's dilemma, promiscuity and functional orthogonality.
Biochemical Society transactions 2009;37(Pt 4):740-4.
2008: Cecilia Blikstad; Abeer Shokeer; Sanela Kurtovic; Bengt Mannervik
Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase.
Biochimica et biophysica acta 2008;1780(12):1458-63.
2008: Sanela Kurtovic; Abeer Shokeer; Bengt Mannervik
Emergence of novel enzyme quasi-species depends on the substrate matrix.
Journal of molecular biology 2008;382(1):136-53.
2008: Françoise Raffalli-Mathieu; Carolina Orre; Mats Stridsberg; Maryam Hansson Edalat; Bengt Mannervik
Targeting human glutathione transferase A3-3 attenuates progesterone production in human steroidogenic cells.
The Biochemical journal 2008;414(1):103-9.
2008: Sanela Kurtovic; Abeer Shokeer; Bengt Mannervik
Diverging catalytic capacities and selectivity profiles with haloalkane substrates of chimeric alpha class glutathione transferases.
Protein engineering, design & selection : PEDS 2008;21(5):329-41.
2008: Sanela Kurtovic; Leif Grehn; Andreas Karlsson; Ulf Hellman; Bengt Mannervik
Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine.
Analytical biochemistry 2008;375(2):339-44.
2008: Usama M Hegazy; Kaspars Tars; Ulf Hellman; Bengt Mannervik
Modulating catalytic activity by unnatural amino acid residues in a GSH-binding loop of GST P1-1.
Journal of molecular biology 2008;376(3):811-26.
2008: Sanela Kurtovic; Olof Modén; Abeer Shokeer; Bengt Mannervik
Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members.
Journal of molecular biology 2008;375(5):1365-79.
2008: Daniel F A R Dourado; Pedro Alexandrino Fernandes; Bengt Mannervik; Maria João Ramos
Glutathione transferase: new model for glutathione activation.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(31):9591-8.
2008: Bengt Mannervik
Molecular enzymology of the glyoxalase system.
Drug metabolism and drug interactions 2008;23(1-2):13-27.
2007: ylva ivarsson; Malena A Norrgård; Ulf Hellman; Bengt Mannervik
Engineering the enantioselectivity of glutathione transferase by combined active-site mutations and chemical modifications.
Biochimica et biophysica acta 2007;1770(9):1374-81.
2007: Sanela Kurtovic; Ronnie Jansson; Bengt Mannervik
Colorimetric endpoint assay for enzyme-catalyzed iodide ion release for high-throughput screening in microtiter plates.
Archives of biochemistry and biophysics 2007;464(2):284-7.
2007: Birgitta I Eklund; Bengt Mannervik
Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs.
Biochimica et biophysica acta 2007;1770(8):1098-103.
2007: Birgitta I Eklund; Sjofn Gunnarsdottir; Adnan A Elfarra; Bengt Mannervik
Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs.
Biochemical pharmacology 2007;73(11):1829-41.
2007: Sanela Kurtovic; Arna Runarsdottir; Lars O Emrén; Anna-Karin Larsson; Bengt Mannervik
Multivariate-activity mining for molecular quasi-species in a glutathione transferase mutant library.
Protein engineering, design & selection : PEDS 2007;20(5):243-56.
2007: Françoise Raffalli-Mathieu; David Persson; Bengt Mannervik
Differences between bovine and human steroid double-bond isomerase activities of Alpha-class glutathione transferases selectively expressed in steroidogenic tissues.
Biochimica et biophysica acta 2007;1770(1):130-6.
2006: P David Josephy; Patricia L Taylor; Gaby Vervaet; Bengt Mannervik
Screening and characterization of variant Theta-class glutathione transferases catalyzing the activation of ethylene dibromide to a mutagen.
Environmental and molecular mutagenesis 2006;47(9):657-65.
2006: Usama M Hegazy; Ulf Hellman; Bengt Mannervik
Replacement surgery with unnatural amino acids in the lock-and-key joint of glutathione transferase subunits.
Chemistry & biology 2006;13(9):929-36.
2006: Birgitta I Eklund; My Moberg; Jonas Bergquist; Bengt Mannervik
Divergent activities of human glutathione transferases in the bioactivation of azathioprine.
Molecular pharmacology 2006;70(2):747-54.
2006: Lars O Emrén; Sanela Kurtovic; Arna Runarsdottir; Anna-Karin Larsson; Bengt Mannervik
Functionally diverging molecular quasi-species evolve by crossing two enzymes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):10866-70.
2006: Stacy K Seeley; Julie A Poposki; John Maksimchuk; Jill Tebbe; Jon Gaudreau; Bengt Mannervik; Arthur W Bull
Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid.
Biochimica et biophysica acta 2006;1760(7):1064-70.
2006: Malena A Norrgård; ylva ivarsson; Kaspars Tars; Bengt Mannervik
Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(13):4876-81.
2006: Elin Grahn; Marian Novotny; Emma Jakobsson; Ann Gustafsson; Leif Grehn; Birgit Olin; Dennis Madsen; Mårten Wahlberg; Bengt Mannervik; Gerard J Kleywegt
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 2):197-207.
2006: Hee-Sung Park; Sung-Hun Nam; Jin Kak Lee; Chang No Yoon; Bengt Mannervik; Stephen J Benkovic; Hak-Sung Kim
Design and evolution of new catalytic activity with an existing protein scaffold.
Science (New York, N.Y.) 2006;311(5760):535-8.
2006: Kaspars Tars; Anna-Karin Larsson; Abeer Shokeer; Birgit Olin; Bengt Mannervik; Gerard J Kleywegt
Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant.
Journal of molecular biology 2006;355(1):96-105.
2005: ylva ivarsson; Bengt Mannervik
Regio- and enantioselectivities in epoxide conjugations are modulated by residue 210 in Mu class glutathione transferases.
Protein engineering, design & selection : PEDS 2005;18(12):607-16.
2005: Abeer Shokeer; Anna-Karin Larsson; Bengt Mannervik
Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates.
The Biochemical journal 2005;388(Pt 1):387-92.
2005: Maryam Edalat; Bengt Mannervik
Peptide phage display for probing GST-protein interactions.
Methods in enzymology 2005;401():354-67.
2005: Françoise Raffalli-Mathieu; Bengt Mannervik
Human glutathione transferase A3-3 active as steroid double-bond isomerase.
Methods in enzymology 2005;401():265-78.
2005: Bengt Mannervik
Optimizing the heterologous expression of glutathione transferase.
Methods in enzymology 2005;401():254-65.
2005: Bengt Mannervik; Philip G Board; John D Hayes; Irving Listowsky; William R Pearson
Nomenclature for mammalian soluble glutathione transferases.
Methods in enzymology 2005;401():1-8.
2005: Monique Akoachere; Rimma Iozef; Stefan Rahlfs; Marcel Deponte; Bengt Mannervik; Donald J Creighton; Heiner Schirmer; Katja Becker
Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts.
Biological chemistry 2005;386(1):41-52.
2004: Sofia Hederos; Kerstin S Broo; Emma Jakobsson; Gerard J Kleywegt; Bengt Mannervik; Lars Baltzer
Incorporation of a single His residue by rational design enables thiol-ester hydrolysis by human glutathione transferase A1-1.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13163-7.
2004: Susanne Wisén; Birgitta Bergman; Bengt Mannervik
Mutagenesis of the cysteine residues in the transcription factor NtcA from Anabaena PCC 7120 and its effects on DNA binding in vitro.
Biochimica et biophysica acta 2004;1679(2):156-63.
2004: Maryam Edalat; Bengt Mannervik; Lars-Göran Axelsson
Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria.
Histochemistry and cell biology 2004;122(2):151-9.
2004: Susanne Wisén; Tove Sjögren; Birgit Olin; Bengt Mannervik
Purification, crystallization and preliminary X-ray data of the transcription factor NtcA from the cyanobacterium Anabaena PCC 7120.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 5):923-5.
2004: Usama M Hegazy; Bengt Mannervik; Gun Stenberg
Functional role of the lock and key motif at the subunit interface of glutathione transferase p1-1.
The Journal of biological chemistry 2004;279(10):9586-96.
2004: Anna-Karin Larsson; Lars O Emrén; William G Bardsley; Bengt Mannervik
Directed enzyme evolution guided by multidimensional analysis of substrate-activity space.
Protein engineering, design & selection : PEDS 2004;17(1):49-55.
2003: Diana S Hamilton; Xiyun Zhang; Zhebo Ding; Ina Hubatsch; Bengt Mannervik; Kendall N Houk; Bruce Ganem; Donald J Creighton
Mechanism of the glutathione transferase-catalyzed conversion of antitumor 2-crotonyloxymethyl-2-cycloalkenones to GSH adducts.
Journal of the American Chemical Society 2003;125(49):15049-58.
2003: Henry J Lin; Ann-Sofie Johansson; Gun Stenberg; Alicia M Materi; Jae Man Park; Aihua Dai; Haiyan Zhou; Jason S Y Gim; Irving H Kau; Steven I Hardy; Michael W Parker; Bengt Mannervik
Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1.
Biochimica et biophysica acta 2003;1649(1):16-23.
2003: Maryam Edalat; Mats A A Persson; Bengt Mannervik
Selective recognition of peptide sequences by glutathione transferases: a possible mechanism for modulation of cellular stress-induced signaling pathways.
Biological chemistry 2003;384(4):645-51.
2003: ylva ivarsson; Aaron J Mackey; Maryam Edalat; William R Pearson; Bengt Mannervik
Identification of residues in glutathione transferase capable of driving functional diversification in evolution. A novel approach to protein redesign.
The Journal of biological chemistry 2003;278(10):8733-8.
2003: Bengt Mannervik
Novel polymorphisms in the glutathione transferase superfamily.
Pharmacogenetics 2003;13(3):127-8.
2003: Geoffrey K-W Kong; Galina Polekhina; William J McKinstry; Michael W Parker; Beatrice Dragani; Antonio Aceto; Domenico Paludi; Daniela Rossi Principe; Bengt Mannervik; Gun Stenberg
Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase p1-1.
The Journal of biological chemistry 2003;278(2):1291-302.
2002: Richard Svensson; Caroline Grenö; Ann-Sofie Johansson; Bengt Mannervik; Ralf Morgenstern
Synthesis and characterization of 6-chloroacetyl-2-dimethylaminonaphthalene as a fluorogenic substrate and a mechanistic probe for glutathione transferases.
Analytical biochemistry 2002;311(2):171-8.
2002: Ákos Végvári; Anna-Karin Larsson; Stellan Hjertén; Bengt Mannervik
High-resolution capillary zone and gel electrophoresis of structurally similar amphipathic glutathione conjugates based on interaction with beta-cyclodextrins.
Chembiochem : a European journal of chemical biology 2002;3(11):1117-25.
2002: Abdel-Monem Abdalla; Christopher M Bruns; John A Tainer; Bengt Mannervik; Gun Stenberg
Design of a monomeric human glutathione transferase GSTP1, a structurally stable but catalytically inactive protein.
Protein engineering 2002;15(10):827-34.
2002: Birgitta I Eklund; Maryam Edalat; Gun Stenberg; Bengt Mannervik
Screening for recombinant glutathione transferases active with monochlorobimane.
Analytical biochemistry 2002;309(1):102-8.
2002: Maryam Edalat; Sven Pettersson; Mats A A Persson; Bengt Mannervik
Probing biomolecular interactions of glutathione transferase M2-2 by using peptide phage display.
Chembiochem : a European journal of chemical biology 2002;3(9):823-8.
2002: Ina Hubatsch; Bengt Mannervik; Ling Gao; L Jackson Roberts; Yan Chen; Jason D Morrow
The cyclopentenone product of lipid peroxidation, 15-A(2t)-isoprostane (8-isoprostaglandin A(2)), is efficiently conjugated with glutathione by human and rat glutathione transferase A4-4.
Chemical research in toxicology 2002;15(9):1114-8.
2002: Pär L Pettersson; Ann-Sofie Johansson; Bengt Mannervik
Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase.
The Journal of biological chemistry 2002;277(33):30019-22.
2002: Lisa O Nilsson; Maryam Edalat; Pär L Pettersson; Bengt Mannervik
Aromatic residues in the C-terminal region of glutathione transferase A1-1 influence rate-determining steps in the catalytic mechanism.
Biochimica et biophysica acta 2002;1598(1-2):199-205.
2002: Xiaojun Ren; Per Jemth; Philip G Board; Guimin Luo; Bengt Mannervik; Junqiu Liu; Kun Zhang; Jiacong Shen
A semisynthetic glutathione peroxidase with high catalytic efficiency. Selenoglutathione transferase.
Chemistry & biology 2002;9(7):789-94.
2002: Kristian Dreij; Kathrin Sundberg; Ann-Sofie Johansson; erik Nordling; Albrecht Seidel; Bengt Persson; Bengt Mannervik; Bengt Jernström
Catalytic activities of human alpha class glutathione transferases toward carcinogenic dibenzo[a,l]pyrene diol epoxides.
Chemical research in toxicology 2002;15(6):825-31.
2002: Lisa O Nilsson; Maryam Edalat; Pär L Pettersson; Bengt Mannervik
Aromatic residues in the C-terminal region of glutathione transferase A1-1 influence rate-determining steps in the catalytic mechanism.
Biochimica et biophysica acta 2002;1597(1):157-63.
2002: Arthur W Bull; Stacy K Seeley; Jason Geno; Bengt Mannervik
Conjugation of the linoleic acid oxidation product, 13-oxooctadeca-9,11-dienoic acid, a bioactive endogenous substrate for mammalian glutathione transferase.
Biochimica et biophysica acta 2002;1571(1):77-82.
2002: Ann-Sofie Johansson; Bengt Mannervik
Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3.
The Journal of biological chemistry 2002;277(19):16648-54.
2002: Kerstin Broo; Anna-Karin Larsson; Per Jemth; Bengt Mannervik
An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes.
Journal of molecular biology 2002;318(1):59-70.
2002: Ann Gustafsson; Lisa O Nilsson; Bengt Mannervik
Hybridization of alpha class subunits generating a functional glutathione transferase A1-4 heterodimer.
Journal of molecular biology 2002;316(2):395-406.
2002: Stanley Mukanganyama; Mikael Widersten; Yogeshkumar Naik; Bengt Mannervik; Julia A Hasler
Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance.
International journal of cancer. Journal international du cancer 2002;97(5):700-5.
2002: Samantha Lien; Anna Karin Larsson; Bengt Mannervik
The polymorphic human glutathione transferase T1-1, the most efficient glutathione transferase in the denitrosation and inactivation of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea.
Biochemical pharmacology 2002;63(2):191-7.
2001: Ann Gustafsson; Pär L Pettersson; Leif Grehn; Per Jemth; Bengt Mannervik
Role of the glutamyl alpha-carboxylate of the substrate glutathione in the catalytic mechanism of human glutathione transferase A1-1.
Biochemistry 2001;40(51):15835-45.
2001: Lisa O Nilsson; Bengt Mannervik
Improved heterologous expression of human glutathione transferase A4-4 by random silent mutagenesis of codons in the 5' region.
Biochimica et biophysica acta 2001;1528(2-3):101-6.
2001: Stanley Mukanganyama; Yogeshkumar Naik; Mikael Widersten; Bengt Mannervik; Julia A Hasler
Proposed reductive metabolism of artemisinin by glutathione transferases in vitro.
Free radical research 2001;35(4):427-34.
2001: S Lien; A Gustafsson; Annika K Andersson; Bengt Mannervik
Human glutathione transferase A1-1 demonstrates both half-of-the-sites and all-of-the-sites reactivity.
The Journal of biological chemistry 2001;276(38):35599-605.
2001: Ann-Sofie Johansson; Bengt Mannervik
Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones.
The Journal of biological chemistry 2001;276(35):33061-5.
2001: Roberta Cocco; Gun Stenberg; Beatrice Dragani; D Rossi Principe; Domenico Paludi; Bengt Mannervik; Antonio Aceto
The folding and stability of human alpha class glutathione transferase A1-1 depend on distinct roles of a conserved N-capping box and hydrophobic staple motif.
The Journal of biological chemistry 2001;276(34):32177-83.
2001: Pär L Pettersson; Bengt Mannervik
The role of glutathione in the isomerization of delta 5-androstene-3,17-dione catalyzed by human glutathione transferase A1-1.
The Journal of biological chemistry 2001;276(15):11698-704.
2001: Ina Hubatsch; Bengt Mannervik
A highly acidic tyrosine 9 and a normally titrating tyrosine 212 contribute to the catalytic mechanism of human glutathione transferase A4-4.
Biochemical and biophysical research communications 2001;280(3):878-82.
2001: E M Frickel; Per Jemth; Mikael Widersten; Bengt Mannervik
Yeast glyoxalase I is a monomeric enzyme with two active sites.
The Journal of biological chemistry 2001;276(3):1845-9.
2000: M Ridderström; Per Jemth; AD Cameron; Bengt Mannervik
The active-site residue tyr-175 in human glyoxalase II contributes to binding of glutathione derivatives.
Biochimica et biophysica acta 2000;1481(2):344-8.
2000: Jamie Rossjohn; William J McKinstry; Aaron J Oakley; Michael W Parker; Gun Stenberg; Bengt Mannervik; Beatrice Dragani; Roberta Cocco; Antonio Aceto
Structures of thermolabile mutants of human glutathione transferase P1-1.
Journal of molecular biology 2000;302(2):295-302.
2000: F Jiang; Susanne Wisén; Mikael Widersten; Birgitta Bergman; Bengt Mannervik
Examination of the transcription factor NtcA-binding motif by in vitro selection of DNA sequences from a random library.
Journal of molecular biology 2000;301(4):783-93.
2000: Lisa O Nilsson; Ann Gustafsson; Bengt Mannervik
Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9408-12.
2000: Alexies Dagnino-Subiabre; Bruce K Cassels; S Baez; Ann-Sofie Johansson; Bengt Mannervik; Juan Segura-Aguilar
Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones.
Biochemical and biophysical research communications 2000;274(1):32-6.
2000: Runa Njålsson; Katarina Carlsson; B Olin; B Carlsson; LA Whitbread; Galina Polekhina; Michael W Parker; Svante Norgren; Bengt Mannervik; Philip G Board; Agne Larsson
Kinetic properties of missense mutations in patients with glutathione synthetase deficiency.
The Biochemical journal 2000;349(Pt 1):275-9.
2000: Gun Stenberg; A M Abdalla; Bengt Mannervik
Tyrosine 50 at the subunit interface of dimeric human glutathione transferase P1-1 is a structural key residue for modulating protein stability and catalytic function.
Biochemical and biophysical research communications 2000;271(1):59-63.
2000: Gun Stenberg; Beatrice Dragani; Roberta Cocco; Bengt Mannervik; Antonio Aceto
A conserved "hydrophobic staple motif" plays a crucial role in the refolding of human glutathione transferase P1-1.
The Journal of biological chemistry 2000;275(14):10421-8.
2000: Per Jemth; Bengt Mannervik
Active site serine promotes stabilization of the reactive glutathione thiolate in rat glutathione transferase T2-2. Evidence against proposed sulfatase activity of the corresponding human enzyme.
The Journal of biological chemistry 2000;275(12):8618-24.
2000: Ann-Sofie Johansson; M Ridderström; Bengt Mannervik
The human glutathione transferase P1-1 specific inhibitor TER 117 designed for overcoming cytostatic-drug resistance is also a strong inhibitor of glyoxalase I.
Molecular pharmacology 2000;57(3):619-24.
2000: Lars O Emrén; Bengt Mannervik
Use of chimeras generated by DNA shuffling: probing structure-function relationships among glutathione transferases.
Methods in enzymology 2000;328():463-77.
2000: Mikael Widersten; Lars O Emrén; L Tronstad; Bengt Mannervik
Use of phage display and transition-state analogs to select enzyme variants with altered catalytic properties: glutathione transferase as an example.
Methods in enzymology 2000;328():389-404.
1999: Ann Gustafsson; M Etahadieh; Per Jemth; Bengt Mannervik
The C-terminal region of human glutathione transferase A1-1 affects the rate of glutathione binding and the ionization of the active-site Tyr9.
Biochemistry 1999;38(49):16268-75.
1999: Lars O Emrén; R Bolton-Grob; Mikael Widersten; Bengt Mannervik
Structural determinants in domain II of human glutathione transferase M2-2 govern the characteristic activities with aminochrome, 2-cyano-1,3-dimethyl-1-nitrosoguanidine, and 1,2-dichloro-4-nitrobenzene.
Protein science : a publication of the Protein Society 1999;8(12):2742-50.
1999: Susanne Wisén; F Jiang; Birgitta Bergman; Bengt Mannervik
Expression and purification of the transcription factor NtcA from the cyanobacterium Anabaena PCC 7120.
Protein expression and purification 1999;17(3):351-7.
1999: Lars O Emrén; Mikael Widersten; Bengt Mannervik
An approach to optimizing the active site in a glutathione transferase by evolution in vitro.
The Biochemical journal 1999;344 Pt 1():93-100.
1999: AD Cameron; M Ridderström; Birgit Olin; MJ Kavarana; Donald J Creighton; Bengt Mannervik
Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry 1999;38(41):13480-90.
1999: Ann-Sofie Johansson; R Bolton-Grob; Bengt Mannervik
Use of silent mutations in cDNA encoding human glutathione transferase M2-2 for optimized expression in Escherichia coli.
Protein expression and purification 1999;17(1):105-12.
1999: AD Cameron; M Ridderström; Birgit Olin; Bengt Mannervik
Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure (London, England : 1993) 1999;7(9):1067-78.
1999: Beatrice Dragani; Roberta Cocco; M Ridderström; Gun Stenberg; Bengt Mannervik; Antonio Aceto
Unfolding and refolding of human glyoxalase II and its single-tryptophan mutants.
Journal of molecular biology 1999;291(2):481-90.
1999: Per Jemth; Bengt Mannervik
Fast product formation and slow product release are important features in a hysteretic reaction mechanism of glutathione transferase T2-2.
Biochemistry 1999;38(31):9982-91.
1999: Helena Danielson; F Jiang; Lars O Emrén; Bengt Mannervik
Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site.
Biochemistry 1999;38(29):9254-63.
1999: Ann Gustafsson; Bengt Mannervik
Benzoic acid derivatives induce recovery of catalytic activity in the partially inactive Met208Lys mutant of human glutathione transferase A1-1.
Journal of molecular biology 1999;288(4):787-800.
1999: Christopher M Bruns; Ina Hubatsch; M Ridderström; Bengt Mannervik; John A Tainer
Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products.
Journal of molecular biology 1999;288(3):427-39.
1999: Lars O Emrén; R Bolton-Grob; T Massoud; Bengt Mannervik
Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling.
Journal of molecular biology 1999;287(2):265-76.
1999: F Jiang; Bengt Mannervik
Optimized heterologous expression of glutathione reductase from Cyanobacterium anabaena PCC 7120 and characterization of the recombinant protein.
Protein expression and purification 1999;15(1):92-8.
1998: Kathrin Sundberg; Albrecht Seidel; Bengt Mannervik; Bengt Jernström
Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione.
FEBS letters 1998;438(3):206-10.
1998: M Ridderström; AD Cameron; T Alwyn Jones; Bengt Mannervik
Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I.
The Journal of biological chemistry 1998;273(34):21623-8.
1998: Ann-Sofie Johansson; Gun Stenberg; Mikael Widersten; Bengt Mannervik
Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105.
Journal of molecular biology 1998;278(3):687-98.
1998: Bengt Mannervik; AD Cameron; E Fernandez; Ann Gustafsson; Lars O Emrén; Per Jemth; F Jiang; T Alwyn Jones; Anna-Karin Larsson; Lisa O Nilsson; Birgit Olin; Pär L Pettersson; M Ridderström; Gun Stenberg; Mikael Widersten
An evolutionary approach to the design of glutathione-linked enzymes.
Chemico-biological interactions 1998;111-112():15-21.
1998: Kathrin Sundberg; Ann-Sofie Johansson; Gun Stenberg; Mikael Widersten; Albrecht Seidel; Bengt Mannervik; Bengt Jernström
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.
Carcinogenesis 1998;19(3):433-6.
1998: Ina Hubatsch; M Ridderström; Bengt Mannervik
Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation.
The Biochemical journal 1998;330 ( Pt 1)():175-9.
1997: Per Jemth; Bengt Mannervik
Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme.
Archives of biochemistry and biophysics 1997;348(2):247-54.
1997: M Ridderström; AD Cameron; T Alwyn Jones; Bengt Mannervik
Mutagenesis of residue 157 in the active site of human glyoxalase I.
The Biochemical journal 1997;328 ( Pt 1)():231-5.
1997: Kathrin Sundberg; Mikael Widersten; Albrecht Seidel; Bengt Mannervik; Bengt Jernström
Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1-1 and P1-1.
Chemical research in toxicology 1997;10(11):1221-7.
1997: F Jiang; Bengt Mannervik; Birgitta Bergman
Evidence for redox regulation of the transcription factor NtcA, acting both as an activator and a repressor, in the cyanobacterium Anabaena PCC 7120.
The Biochemical journal 1997;327 ( Pt 2)():513-7.
1997: Beatrice Dragani; Gun Stenberg; Sonia Melino; Raffaele Petruzzelli; Bengt Mannervik; Antonio Aceto
The conserved N-capping box in the hydrophobic core of glutathione S-transferase P1-1 is essential for refolding. Identification of a buried and conserved hydrogen bond important for protein stability.
The Journal of biological chemistry 1997;272(41):25518-23.
1997: Lars O Emrén; Mikael Widersten; Bengt Mannervik
Mechanism-based phage display selection of active-site mutants of human glutathione transferase A1-1 catalyzing SNAr reactions.
Biochemistry 1997;36(37):11252-60.
1997: Niklas Dahl; Maritta Pigg; E Ristoff; R Gali; B Carlsson; Bengt Mannervik; Agne Larsson; P Board
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction.
Human molecular genetics 1997;6(7):1147-52.
1997: AD Cameron; Birgit Olin; M Ridderström; Bengt Mannervik; T Alwyn Jones
Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping.
The EMBO journal 1997;16(12):3386-95.
1997: S Baez; Juan Segura-Aguilar; Mikael Widersten; Ann-Sofie Johansson; Bengt Mannervik
Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes.
The Biochemical journal 1997;324 ( Pt 1)():25-8.
1997: M Ridderström; Bengt Mannervik
Molecular cloning and characterization of the thiolesterase glyoxalase II from Arabidopsis thaliana.
The Biochemical journal 1997;322 ( Pt 2)():449-54.
1997: Juan Segura-Aguilar; S Baez; Mikael Widersten; CJ Welch; Bengt Mannervik
Human class Mu glutathione transferases, in particular isoenzyme M2-2, catalyze detoxication of the dopamine metabolite aminochrome.
The Journal of biological chemistry 1997;272(9):5727-31.
1996: Bengt Mannervik
Evolution of glutathione transferases and related enzymes for the protection of cells against electrophiles.
Biochemical Society transactions 1996;24(3):878-80.
1996: B Jernstrom; M Funk; H Frank; Bengt Mannervik; Albrecht Seidel
Glutathione S-transferase A1-1-catalysed conjugation of bay and fjord region diol epoxides or polycyclic aromatic hydrocarbons with glutathione.
Carcinogenesis 1996;17(7):1491-8.
1996: Mikael Widersten; R Björnestedt; Bengt Mannervik
Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1.
Biochemistry 1996;35(24):7731-42.
1996: Mikael Widersten; M Huang; Bengt Mannervik
Optimized heterologous expression of the polymorphic human glutathione transferase M1-1 based on silent mutations in the corresponding cDNA.
Protein expression and purification 1996;7(4):367-72.
1996: Per Jemth; Gun Stenberg; G Chaga; Bengt Mannervik
Heterologous expression, purification and characterization of rat class theta glutathione transferase T2-2.
The Biochemical journal 1996;316 ( Pt 1)():131-6.
1996: M Ridderström; Bengt Mannervik
Optimized heterologous expression of the human zinc enzyme glyoxalase I.
The Biochemical journal 1996;314 ( Pt 2)():463-7.
1996: M Ridderström; Franca Saccucci; U Hellman; T Bergman; Giovanni Principato; Bengt Mannervik
Molecular cloning, heterologous expression, and characterization of human glyoxalase II.
The Journal of biological chemistry 1996;271(1):319-23.
1996: Johan Hansson; M R Edgren; Suzanne Egyházi; X Y Hao; Bengt Mannervik; Ulrik Ringborg
Increased cisplatin sensitivity of human fibroblasts from a subject with inherent glutathione deficiency.
Acta oncologica (Stockholm, Sweden) 1996;35(6):683-90.
1995: R Björnestedt; S Tardioli; Bengt Mannervik
The high activity of rat glutathione transferase 8-8 with alkene substrates is dependent on a glycine residue in the active site.
The Journal of biological chemistry 1995;270(50):29705-9.
1995: S Yilmaz; Mikael Widersten; T Emahazion; Bengt Mannervik
Generation of a Ni(II) binding site by introduction of a histidine cluster in the structure of human glutathione transferase A1-1.
Protein engineering 1995;8(11):1163-9.
1995: R H Kolm; Helena Danielson; Y Zhang; Paul Talalay; Bengt Mannervik
Isothiocyanates as substrates for human glutathione transferases: structure-activity studies.
The Biochemical journal 1995;311 ( Pt 2)():453-9.
1995: F Jiang; U Hellman; G E Sroga; Birgitta Bergman; Bengt Mannervik
Cloning, sequencing, and regulation of the glutathione reductase gene from the cyanobacterium Anabaena PCC 7120.
The Journal of biological chemistry 1995;270(39):22882-9.
1995: AD Cameron; I Sinning; G L'Hermite; Birgit Olin; P G Board; Bengt Mannervik; T Alwyn Jones
Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure (London, England : 1993) 1995;3(7):717-27.
1995: Mikael Widersten; Bengt Mannervik
Glutathione transferases with novel active sites isolated by phage display from a library of random mutants.
Journal of molecular biology 1995;250(2):115-22.
1995: R H Kolm; Gun Stenberg; Mikael Widersten; Bengt Mannervik
High-level bacterial expression of human glutathione transferase P1-1 encoded by semisynthetic DNA.
Protein expression and purification 1995;6(3):265-71.
1995: R Björnestedt; Gun Stenberg; Mikael Widersten; P G Board; I Sinning; T Alwyn Jones; Bengt Mannervik
Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1.
Journal of molecular biology 1995;247(4):765-73.
1995: Y Zhang; R H Kolm; Bengt Mannervik; Paul Talalay
Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases.
Biochemical and biophysical research communications 1995;206(2):748-55.
1995: K Berhane; X Y Hao; B Christensson; Johan Hansson; Ulrik Ringborg; Bengt Mannervik
The expression of glutathione transferase isoenzymes in human malignant lymphoma biopsies.
Acta oncologica (Stockholm, Sweden) 1995;34(1):35-41.
1995: A Platz; U Jungnelius; E Grafström; B Lagerlöf; Bengt Mannervik; Ulrik Ringborg
Glutathione transferase P1-1 expression in human melanoma metastases: correlation to N-RAS mutations and expression.
Acta oncologica (Stockholm, Sweden) 1995;34(6):759-65.
1994: Mikael Widersten; R Björnestedt; Bengt Mannervik
Contribution of amino acid residue 208 in the hydrophobic binding site to the catalytic mechanism of human glutathione transferase A1-1.
Biochemistry 1994;33(39):11717-23.
1994: G Chaga; Mikael Widersten; L Andersson; J Porath; Helena Danielson; Bengt Mannervik
Engineering of a metal coordinating site into human glutathione transferase M1-1 based on immobilized metal ion affinity chromatography of homologous rat enzymes.
Protein engineering 1994;7(9):1115-9.
1994: X Y Hao; Jonas Bergh; Ola Brodin; U Hellman; Bengt Mannervik
Acquired resistance to cisplatin and doxorubicin in a small cell lung cancer cell line is correlated to elevated expression of glutathione-linked detoxification enzymes.
Carcinogenesis 1994;15(6):1167-73.
1994: U Jungnelius; M Ridderström; Johan Hansson; Ulrik Ringborg; Bengt Mannervik
Similar toxic effect of 1,3-bis(2-chloroethyl)-1-nitrosourea on lymphocytes from human subjects differing in the expression of glutathione transferase M1-1.
Biochemical pharmacology 1994;47(10):1777-80.
1994: K Berhane; Mikael Widersten; Ake Engström; J W Kozarich; Bengt Mannervik
Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1480-4.
1994: X Y Hao; V M Castro; J Bergh; B Sundström; Bengt Mannervik
Isoenzyme-specific quantitative immunoassays for cytosolic glutathione transferases and measurement of the enzymes in blood plasma from cancer patients and in tumor cell lines.
Biochimica et biophysica acta 1994;1225(2):223-30.
1994: U Jungnelius; X Y Hao; S Skog; V M Castro; Bengt Mannervik; Ulrik Ringborg
Cell cycle dependent sensitivity of human melanoma cells to melphalan is correlated with the activity and cellular concentration of glutathione transferases.
Carcinogenesis 1994;15(1):99-103.
1994: X Y Hao; Mikael Widersten; M Ridderström; U Hellman; Bengt Mannervik
Co-variation of glutathione transferase expression and cytostatic drug resistance in HeLa cells: establishment of class Mu glutathione transferase M3-3 as the dominating isoenzyme.
The Biochemical journal 1994;297 ( Pt 1)():59-67.
1993: K Berhane; X Y Hao; Suzanne Egyházi; Johan Hansson; Ulrik Ringborg; Bengt Mannervik
Contribution of glutathione transferase M3-3 to 1,3-bis(2-chloroethyl)-1-nitrosourea resistance in a human non-small cell lung cancer cell line.
Cancer research 1993;53(18):4257-61.
1993: Bengt Mannervik; M Ridderström
Catalytic and molecular properties of glyoxalase I.
Biochemical Society transactions 1993;21(2):515-7.
1993: Karin Klinga-Levan; A Andersson; Charles Hanson; M Ridderström; Gun Stenberg; Bengt Mannervik; M Vajdy; Josiane Szpirer; Claude Szpirer; Göran Levan
Mapping of glutathione transferase (GST) genes in the rat.
Hereditas 1993;119(3):285-96.
1992: Mikael Widersten; Bengt Mannervik
A structural role of histidine 15 in human glutathione transferase M1-1, an amino acid residue conserved in class Mu enzymes.
Protein engineering 1992;5(6):551-7.
1992: L Staffas; L Mankowitz; M Söderström; A Blanck; I Porsch-Hällström; C Sundberg; Bengt Mannervik; B Olin; J Rydström; Joseph W DePierre
Further characterization of hormonal regulation of glutathione transferase in rat liver and adrenal glands. Sex differences and demonstration that growth hormone regulates the hepatic levels.
The Biochemical journal 1992;286 ( Pt 1)():65-72.
1992: R H Kolm; G E Sroga; Bengt Mannervik
Participation of the phenolic hydroxyl group of Tyr-8 in the catalytic mechanism of human glutathione transferase P1-1.
The Biochemical journal 1992;285 ( Pt 2)():537-40.
1992: Mikael Widersten; R H Kolm; R Björnestedt; Bengt Mannervik
Contribution of five amino acid residues in the glutathione-binding site to the function of human glutathione transferase P1-1.
The Biochemical journal 1992;285 ( Pt 2)():377-81.
1992: Gun Stenberg; M Ridderström; Ake Engström; S E Pemble; Bengt Mannervik
Cloning and heterologous expression of cDNA encoding class alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic alpha,beta-unsaturated carbonyl compounds.
The Biochemical journal 1992;284 ( Pt 2)():313-9.
1992: M Söderström; Bengt Mannervik; V Garkov; S Hammarström
On the nature of leukotriene C4 synthase in human platelets.
Archives of biochemistry and biophysics 1992;294(1):70-4.
1992: R Björnestedt; Mikael Widersten; P G Board; Bengt Mannervik
Design of two chimaeric human-rat class alpha glutathione transferases for probing the contribution of C-terminal segments of protein structure to the catalytic properties.
The Biochemical journal 1992;282 ( Pt 2)():505-10.
1992: Gun Stenberg; R Björnestedt; Bengt Mannervik
Heterologous expression of recombinant human glutathione transferase A1-1 from a hepatoma cell line.
Protein expression and purification 1992;3(1):80-4.
1991: L Mankowitz; Joseph W DePierre; Bengt Mannervik; H A Hansson
Immunohistochemical distribution of isoenzymes of glutathione transferase in adult rat adrenal gland before and after hypophysectomy.
The Biochemical journal 1991;280 ( Pt 2)():399-405.
1991: Mikael Widersten; E Holmström; Bengt Mannervik
Cysteine residues are not essential for the catalytic activity of human class Mu glutathione transferase M1a-1a.
FEBS letters 1991;293(1-2):156-9.
1991: Gun Stenberg; P G Board; Bengt Mannervik
Mutation of an evolutionarily conserved tyrosine residue in the active site of a human class Alpha glutathione transferase.
FEBS letters 1991;293(1-2):153-5.
1991: Mikael Widersten; W R Pearson; Ake Engström; Bengt Mannervik
Heterologous expression of the allelic variant mu-class glutathione transferases mu and psi.
The Biochemical journal 1991;276 ( Pt 2)():519-24.
1991: S Sellin; B Holmquist; Bengt Mannervik; B L Vallee
Oxidation and reduction of 4-hydroxyalkenals catalyzed by isozymes of human alcohol dehydrogenase.
Biochemistry 1991;30(9):2514-8.
1991: Gun Stenberg; P G Board; I Carlberg; Bengt Mannervik
Effects of directed mutagenesis on conserved arginine residues in a human Class Alpha glutathione transferase.
The Biochemical journal 1991;274 ( Pt 2)():549-55.
1991: Johan Hansson; K Berhane; V M Castro; U Jungnelius; Bengt Mannervik; Ulrik Ringborg
Sensitization of human melanoma cells to the cytotoxic effect of melphalan by the glutathione transferase inhibitor ethacrynic acid.
Cancer research 1991;51(1):94-8.
1990: V M Castro; M Söderström; I Carlberg; Mikael Widersten; A Platz; Bengt Mannervik
Differences among human tumor cell lines in the expression of glutathione transferases and other glutathione-linked enzymes.
Carcinogenesis 1990;11(9):1569-76.
1990: K Berhane; Bengt Mannervik
Inactivation of the genotoxic aldehyde acrolein by human glutathione transferases of classes alpha, mu, and pi.
Molecular pharmacology 1990;37(2):251-4.
1990: L Mankowitz; V M Castro; Bengt Mannervik; J Rydström; Joseph W DePierre
Increase in the amount of glutathione transferase 4-4 in the rat adrenal gland after hypophysectomy and down-regulation by subsequent treatment with adrenocorticotrophic hormone.
The Biochemical journal 1990;265(1):147-54.
1990: Bengt Mannervik; K Berhane; V M Castro; Birgit Olin; M Ridderström; R Vignani; J W Kozarich; Ulrik Ringborg
Glutathione-linked enzymes in normal and tumor cells and their role in resistance against genotoxic agents.
Princess Takamatsu symposia 1990;21():253-62.
1989: S W Cowan; T Bergfors; T Alwyn Jones; G Tibbelin; Birgit Olin; P G Board; Bengt Mannervik
Crystallization of GST2, a human class alpha glutathione transferase.
Journal of molecular biology 1989;208(2):369-70.
1988: Bengt Mannervik; Helena Danielson
Glutathione transferases--structure and catalytic activity.
CRC critical reviews in biochemistry 1988;23(3):283-337.