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Bengt Mannervik

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
30
Widersten, Mikael
22
Stenberg, Gun
19
Ridderström, M
12
Johansson, Ann-Sofie
11
Jemth, Per
10
Olin, Birgit
10
Kurtovic, Sanela
8
Ringborg, Ulrik
8
Hansson, LO
8
Larsson, Anna-Karin
8
Cameron, AD
8
Edalat, Maryam
7
Gustafsson, Ann
7
Jones, Alwyn
6
Jiang, F

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Publications

TOP 3
Kurtovic Sanela; Mannervik Bengt
Identification of emerging quasi-species in directed enzyme evolution.
Josephy P David; Kent Meredith; Mannervik Bengt
Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties.
Balogh Larissa M; Le Trong Isolde; Kripps Kimberly A; Tars Kaspars; Stenkamp Ronald E; Mannervik Bengt; Atkins William M
Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals.

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All Publications

2009: Kurtovic Sanela; Mannervik Bengt
Identification of emerging quasi-species in directed enzyme evolution.
Biochemistry 2009;48(40):9330-9.
2009: Josephy P David; Kent Meredith; Mannervik Bengt
Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties.
Archives of biochemistry and biophysics 2009;490(1):24-9.
2009: Balogh Larissa M; Le Trong Isolde; Kripps Kimberly A; Tars Kaspars; Stenkamp Ronald E; Mannervik Bengt; Atkins William M
Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals.
Biochemistry 2009;48(32):7698-704.
2009: Mannervik Bengt; Runarsdottir Arna; Kurtovic Sanela
Multi-substrate-activity space and quasi-species in enzyme evolution: Ohno's dilemma, promiscuity and functional orthogonality.
Biochemical Society transactions 2009;37(Pt 4):740-4.
2008: Blikstad Cecilia; Shokeer Abeer; Kurtovic Sanela; Mannervik Bengt
Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase.
Biochimica et biophysica acta 2008;1780(12):1458-63.
2008: Kurtovic Sanela; Shokeer Abeer; Mannervik Bengt
Emergence of novel enzyme quasi-species depends on the substrate matrix.
Journal of molecular biology 2008;382(1):136-53.
2008: Raffalli-Mathieu Françoise; Orre Carolina; Stridsberg Mats; Hansson Edalat Maryam; Mannervik Bengt
Targeting human glutathione transferase A3-3 attenuates progesterone production in human steroidogenic cells.
The Biochemical journal 2008;414(1):103-9.
2008: Kurtovic Sanela; Shokeer Abeer; Mannervik Bengt
Diverging catalytic capacities and selectivity profiles with haloalkane substrates of chimeric alpha class glutathione transferases.
Protein engineering, design & selection : PEDS 2008;21(5):329-41.
2008: Kurtovic Sanela; Grehn Leif; Karlsson Andreas; Hellman Ulf; Mannervik Bengt
Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine.
Analytical biochemistry 2008;375(2):339-44.
2008: Hegazy Usama M; Tars Kaspars; Hellman Ulf; Mannervik Bengt
Modulating catalytic activity by unnatural amino acid residues in a GSH-binding loop of GST P1-1.
Journal of molecular biology 2008;376(3):811-26.
2008: Kurtovic Sanela; Modén Olof; Shokeer Abeer; Mannervik Bengt
Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members.
Journal of molecular biology 2008;375(5):1365-79.
2008: Dourado Daniel F A R; Fernandes Pedro Alexandrino; Mannervik Bengt; Ramos Maria João
Glutathione transferase: new model for glutathione activation.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(31):9591-8.
2008: Mannervik Bengt
Molecular enzymology of the glyoxalase system.
Drug metabolism and drug interactions 2008;23(1-2):13-27.
2007: Ivarsson Ylva; Norrgård Malena A; Hellman Ulf; Mannervik Bengt
Engineering the enantioselectivity of glutathione transferase by combined active-site mutations and chemical modifications.
Biochimica et biophysica acta 2007;1770(9):1374-81.
2007: Eklund Birgitta I; Mannervik Bengt
Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs.
Biochimica et biophysica acta 2007;1770(8):1098-103.
2007: Kurtovic Sanela; Jansson Ronnie; Mannervik Bengt
Colorimetric endpoint assay for enzyme-catalyzed iodide ion release for high-throughput screening in microtiter plates.
Archives of biochemistry and biophysics 2007;464(2):284-7.
2007: Eklund Birgitta I; Gunnarsdottir Sjofn; Elfarra Adnan A; Mannervik Bengt
Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs.
Biochemical pharmacology 2007;73(11):1829-41.
2007: Kurtovic Sanela; Runarsdottir Arna; Emrén Lars O; Larsson Anna-Karin; Mannervik Bengt
Multivariate-activity mining for molecular quasi-species in a glutathione transferase mutant library.
Protein engineering, design & selection : PEDS 2007;20(5):243-56.
2007: Raffalli-Mathieu Françoise; Persson David; Mannervik Bengt
Differences between bovine and human steroid double-bond isomerase activities of Alpha-class glutathione transferases selectively expressed in steroidogenic tissues.
Biochimica et biophysica acta 2007;1770(1):130-6.
2006: Josephy P David; Taylor Patricia L; Vervaet Gaby; Mannervik Bengt
Screening and characterization of variant Theta-class glutathione transferases catalyzing the activation of ethylene dibromide to a mutagen.
Environmental and molecular mutagenesis 2006;47(9):657-65.
2006: Hegazy Usama M; Hellman Ulf; Mannervik Bengt
Replacement surgery with unnatural amino acids in the lock-and-key joint of glutathione transferase subunits.
Chemistry & biology 2006;13(9):929-36.
2006: Eklund Birgitta I; Moberg My; Bergquist Jonas; Mannervik Bengt
Divergent activities of human glutathione transferases in the bioactivation of azathioprine.
Molecular pharmacology 2006;70(2):747-54.
2006: Emrén Lars O; Kurtovic Sanela; Runarsdottir Arna; Larsson Anna-Karin; Mannervik Bengt
Functionally diverging molecular quasi-species evolve by crossing two enzymes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):10866-70.
2006: Seeley Stacy K; Poposki Julie A; Maksimchuk John; Tebbe Jill; Gaudreau Jon; Mannervik Bengt; Bull Arthur W
Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid.
Biochimica et biophysica acta 2006;1760(7):1064-70.
2006: Norrgård Malena A; Ivarsson Ylva; Tars Kaspars; Mannervik Bengt
Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(13):4876-81.
2006: Grahn Elin; Novotny Marian; Jakobsson Emma; Gustafsson Ann; Grehn Leif; Olin Birgit; Madsen Dennis; Wahlberg Mårten; Mannervik Bengt; Kleywegt Gerard J
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 2):197-207.
2006: Park Hee-Sung; Nam Sung-Hun; Lee Jin Kak; Yoon Chang No; Mannervik Bengt; Benkovic Stephen J; Kim Hak-Sung
Design and evolution of new catalytic activity with an existing protein scaffold.
Science (New York, N.Y.) 2006;311(5760):535-8.
2006: Tars Kaspars; Larsson Anna-Karin; Shokeer Abeer; Olin Birgit; Mannervik Bengt; Kleywegt Gerard J
Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant.
Journal of molecular biology 2006;355(1):96-105.
2005: Ivarsson Ylva; Mannervik Bengt
Regio- and enantioselectivities in epoxide conjugations are modulated by residue 210 in Mu class glutathione transferases.
Protein engineering, design & selection : PEDS 2005;18(12):607-16.
2005: Shokeer Abeer; Larsson Anna-Karin; Mannervik Bengt
Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates.
The Biochemical journal 2005;388(Pt 1):387-92.
2005: Akoachere Monique; Iozef Rimma; Rahlfs Stefan; Deponte Marcel; Mannervik Bengt; Creighton Donald J; Schirmer Heiner; Becker Katja
Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts.
Biological chemistry 2005;386(1):41-52.
2005: Edalat Maryam H; Mannervik Bengt
Peptide phage display for probing GST-protein interactions.
Methods in enzymology 2005;401():354-67.
2005: Raffalli-Mathieu Françoise; Mannervik Bengt
Human glutathione transferase A3-3 active as steroid double-bond isomerase.
Methods in enzymology 2005;401():265-78.
2005: Mannervik Bengt
Optimizing the heterologous expression of glutathione transferase.
Methods in enzymology 2005;401():254-65.
2005: Mannervik Bengt; Board Philip G; Hayes John D; Listowsky Irving; Pearson William R
Nomenclature for mammalian soluble glutathione transferases.
Methods in enzymology 2005;401():1-8.
2004: Hederos Sofia; Broo Kerstin S; Jakobsson Emma; Kleywegt Gerard J; Mannervik Bengt; Baltzer Lars
Incorporation of a single His residue by rational design enables thiol-ester hydrolysis by human glutathione transferase A1-1.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13163-7.
2004: Edalat Maryam; Mannervik Bengt; Axelsson Lars-Göran
Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria.
Histochemistry and cell biology 2004;122(2):151-9.
2004: Wisén Susanne; Bergman Birgitta; Mannervik Bengt
Mutagenesis of the cysteine residues in the transcription factor NtcA from Anabaena PCC 7120 and its effects on DNA binding in vitro.
Biochimica et biophysica acta 2004;1679(2):156-63.
2004: Wisén Susanne; Sjögren Tove; Olin Birgit; Mannervik Bengt
Purification, crystallization and preliminary X-ray data of the transcription factor NtcA from the cyanobacterium Anabaena PCC 7120.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 5):923-5.
2004: Hegazy Usama M; Mannervik Bengt; Stenberg Gun
Functional role of the lock and key motif at the subunit interface of glutathione transferase p1-1.
The Journal of biological chemistry 2004;279(10):9586-96.
2004: Larsson Anna-Karin; Emrén Lars O; Bardsley William G; Mannervik Bengt
Directed enzyme evolution guided by multidimensional analysis of substrate-activity space.
Protein engineering, design & selection : PEDS 2004;17(1):49-55.
2003: Hamilton Diana S; Zhang Xiyun; Ding Zhebo; Hubatsch Ina; Mannervik Bengt; Houk K N; Ganem Bruce; Creighton Donald J
Mechanism of the glutathione transferase-catalyzed conversion of antitumor 2-crotonyloxymethyl-2-cycloalkenones to GSH adducts.
Journal of the American Chemical Society 2003;125(49):15049-58.
2003: Lin Henry J; Johansson Ann Sofie; Stenberg Gun; Materi Alicia M; Park Jae Man; Dai Aihua; Zhou Haiyan; Gim Jason S Y; Kau Irving H; Hardy Steven I; Parker Michael W; Mannervik Bengt
Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1.
Biochimica et biophysica acta 2003;1649(1):16-23.
2003: Edalat Maryam; Persson Mats A A; Mannervik Bengt
Selective recognition of peptide sequences by glutathione transferases: a possible mechanism for modulation of cellular stress-induced signaling pathways.
Biological chemistry 2003;384(4):645-51.
2003: Mannervik Bengt
Novel polymorphisms in the glutathione transferase superfamily.
Pharmacogenetics 2003;13(3):127-8.
2003: Ivarsson Ylva; Mackey Aaron J; Edalat Maryam; Pearson William R; Mannervik Bengt
Identification of residues in glutathione transferase capable of driving functional diversification in evolution. A novel approach to protein redesign.
The Journal of biological chemistry 2003;278(10):8733-8.
2003: Kong Geoffrey K-W; Polekhina Galina; McKinstry William J; Parker Michael W; Dragani Beatrice; Aceto Antonio; Paludi Domenico; Principe Daniela Rossi; Mannervik Bengt; Stenberg Gun
Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase p1-1.
The Journal of biological chemistry 2003;278(2):1291-302.
2002: Svensson Richard; Grenö Caroline; Johansson Ann-Sofie; Mannervik Bengt; Morgenstern Ralf
Synthesis and characterization of 6-chloroacetyl-2-dimethylaminonaphthalene as a fluorogenic substrate and a mechanistic probe for glutathione transferases.
Analytical biochemistry 2002;311(2):171-8.
2002: Végvári Akos; Larsson Anna-Karin; Hjertén Stellan; Mannervik Bengt
High-resolution capillary zone and gel electrophoresis of structurally similar amphipathic glutathione conjugates based on interaction with beta-cyclodextrins.
Chembiochem : a European journal of chemical biology 2002;3(11):1117-25.
2002: Abdalla Abdel-Monem; Bruns Christopher M; Tainer John A; Mannervik Bengt; Stenberg Gun
Design of a monomeric human glutathione transferase GSTP1, a structurally stable but catalytically inactive protein.
Protein engineering 2002;15(10):827-34.
2002: Eklund Birgitta I; Edalat Maryam; Stenberg Gun; Mannervik Bengt
Screening for recombinant glutathione transferases active with monochlorobimane.
Analytical biochemistry 2002;309(1):102-8.
2002: Hubatsch Ina; Mannervik Bengt; Gao Ling; Roberts L Jackson; Chen Yan; Morrow Jason D
The cyclopentenone product of lipid peroxidation, 15-A(2t)-isoprostane (8-isoprostaglandin A(2)), is efficiently conjugated with glutathione by human and rat glutathione transferase A4-4.
Chemical research in toxicology 2002;15(9):1114-8.
2002: Edalat Maryam; Pettersson Sven; Persson Mats A A; Mannervik Bengt
Probing biomolecular interactions of glutathione transferase M2-2 by using peptide phage display.
Chembiochem : a European journal of chemical biology 2002;3(9):823-8.
2002: Pettersson Par L; Johansson Ann-Sofie; Mannervik Bengt
Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase.
The Journal of biological chemistry 2002;277(33):30019-22.
2002: Nilsson Lisa O; Edalat Maryam; Pettersson Pär L; Mannervik Bengt
Aromatic residues in the C-terminal region of glutathione transferase A1-1 influence rate-determining steps in the catalytic mechanism.
Biochimica et biophysica acta 2002;1598(1-2):199-205.
2002: Ren Xiaojun; Jemth Per; Board Philip G; Luo Guimin; Mannervik Bengt; Liu Junqiu; Zhang Kun; Shen Jiacong
A semisynthetic glutathione peroxidase with high catalytic efficiency. Selenoglutathione transferase.
Chemistry & biology 2002;9(7):789-94.
2002: Dreij Kristian; Sundberg Kathrin; Johansson Ann-Sofie; Nordling Erik; Seidel Albrecht; Persson Bengt; Mannervik Bengt; Jernström Bengt
Catalytic activities of human alpha class glutathione transferases toward carcinogenic dibenzo[a,l]pyrene diol epoxides.
Chemical research in toxicology 2002;15(6):825-31.
2002: Bull Arthur W; Seeley Stacy K; Geno Jason; Mannervik Bengt
Conjugation of the linoleic acid oxidation product, 13-oxooctadeca-9,11-dienoic acid, a bioactive endogenous substrate for mammalian glutathione transferase.
Biochimica et biophysica acta 2002;1571(1):77-82.
2002: Nilsson Lisa O; Edalat Maryam; Pettersson Pär L; Mannervik Bengt
Aromatic residues in the C-terminal region of glutathione transferase A1-1 influence rate-determining steps in the catalytic mechanism.
Biochimica et biophysica acta 2002;1597(1):157-63.
2002: Johansson Ann-Sofie; Mannervik Bengt
Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3.
The Journal of biological chemistry 2002;277(19):16648-54.
2002: Broo Kerstin; Larsson Anna-Karin; Jemth Per; Mannervik Bengt
An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes.
Journal of molecular biology 2002;318(1):59-70.
2002: Gustafsson Ann; Nilsson Lisa O; Mannervik Bengt
Hybridization of alpha class subunits generating a functional glutathione transferase A1-4 heterodimer.
Journal of molecular biology 2002;316(2):395-406.
2002: Mukanganyama Stanley; Widersten Mikael; Naik Yogeshkumar S; Mannervik Bengt; Hasler Julia A
Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance.
International journal of cancer. Journal international du cancer 2002;97(5):700-5.
2002: Lien Samantha; Larsson Anna Karin; Mannervik Bengt
The polymorphic human glutathione transferase T1-1, the most efficient glutathione transferase in the denitrosation and inactivation of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea.
Biochemical pharmacology 2002;63(2):191-7.
2001: Gustafsson A; Pettersson P L; Grehn L; Jemth P; Mannervik B
Role of the glutamyl alpha-carboxylate of the substrate glutathione in the catalytic mechanism of human glutathione transferase A1-1.
Biochemistry 2001;40(51):15835-45.
2001: Mukanganyama S; Naik Y S; Widersten M; Mannervik B; Hasler J A
Proposed reductive metabolism of artemisinin by glutathione transferases in vitro.
Free radical research 2001;35(4):427-34.
2001: Nilsson L O; Mannervik B
Improved heterologous expression of human glutathione transferase A4-4 by random silent mutagenesis of codons in the 5' region.
Biochimica et biophysica acta 2001;1528(2-3):101-6.
2001: Lien S; Gustafsson A; Andersson A K; Mannervik B
Human glutathione transferase A1-1 demonstrates both half-of-the-sites and all-of-the-sites reactivity.
The Journal of biological chemistry 2001;276(38):35599-605.
2001: Cocco R; Stenberg G; Dragani B; Rossi Principe D; Paludi D; Mannervik B; Aceto A
The folding and stability of human alpha class glutathione transferase A1-1 depend on distinct roles of a conserved N-capping box and hydrophobic staple motif.
The Journal of biological chemistry 2001;276(34):32177-83.
2001: Johansson A S; Mannervik B
Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones.
The Journal of biological chemistry 2001;276(35):33061-5.
2001: Pettersson P L; Mannervik B
The role of glutathione in the isomerization of delta 5-androstene-3,17-dione catalyzed by human glutathione transferase A1-1.
The Journal of biological chemistry 2001;276(15):11698-704.
2001: Hubatsch I; Mannervik B
A highly acidic tyrosine 9 and a normally titrating tyrosine 212 contribute to the catalytic mechanism of human glutathione transferase A4-4.
Biochemical and biophysical research communications 2001;280(3):878-82.
2001: Frickel E M; Jemth P; Widersten M; Mannervik B
Yeast glyoxalase I is a monomeric enzyme with two active sites.
The Journal of biological chemistry 2001;276(3):1845-9.
2000: Ridderström M; Jemth P; Cameron A D; Mannervik B
The active-site residue tyr-175 in human glyoxalase II contributes to binding of glutathione derivatives.
Biochimica et biophysica acta 2000;1481(2):344-8.
2000: Rossjohn J; McKinstry W J; Oakley A J; Parker M W; Stenberg G; Mannervik B; Dragani B; Cocco R; Aceto A
Structures of thermolabile mutants of human glutathione transferase P1-1.
Journal of molecular biology 2000;302(2):295-302.
2000: Jiang F; Wisén S; Widersten M; Bergman B; Mannervik B
Examination of the transcription factor NtcA-binding motif by in vitro selection of DNA sequences from a random library.
Journal of molecular biology 2000;301(4):783-93.
2000: Nilsson L O; Gustafsson A; Mannervik B
Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9408-12.
2000: Dagnino-Subiabre A; Cassels B K; Baez S; Johansson A S; Mannervik B; Segura-Aguilar J
Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones.
Biochemical and biophysical research communications 2000;274(1):32-6.
2000: Njålsson R; Carlsson K; Olin B; Carlsson B; Whitbread L; Polekhina G; Parker M W; Norgren S; Mannervik B; Board P G; Larsson A
Kinetic properties of missense mutations in patients with glutathione synthetase deficiency.
The Biochemical journal 2000;349(Pt 1):275-9.
2000: Stenberg G; Abdalla A M; Mannervik B
Tyrosine 50 at the subunit interface of dimeric human glutathione transferase P1-1 is a structural key residue for modulating protein stability and catalytic function.
Biochemical and biophysical research communications 2000;271(1):59-63.
2000: Stenberg G; Dragani B; Cocco R; Mannervik B; Aceto A
A conserved "hydrophobic staple motif" plays a crucial role in the refolding of human glutathione transferase P1-1.
The Journal of biological chemistry 2000;275(14):10421-8.
2000: Jemth P; Mannervik B
Active site serine promotes stabilization of the reactive glutathione thiolate in rat glutathione transferase T2-2. Evidence against proposed sulfatase activity of the corresponding human enzyme.
The Journal of biological chemistry 2000;275(12):8618-24.
2000: Johansson A S; Ridderström M; Mannervik B
The human glutathione transferase P1-1 specific inhibitor TER 117 designed for overcoming cytostatic-drug resistance is also a strong inhibitor of glyoxalase I.
Molecular pharmacology 2000;57(3):619-24.
2000: Hansson L O; Mannervik B
Use of chimeras generated by DNA shuffling: probing structure-function relationships among glutathione transferases.
Methods in enzymology 2000;328():463-77.
2000: Widersten M; Hansson L O; Tronstad L; Mannervik B
Use of phage display and transition-state analogs to select enzyme variants with altered catalytic properties: glutathione transferase as an example.
Methods in enzymology 2000;328():389-404.
1999: Hansson L O; Bolton-Grob R; Widersten M; Mannervik B
Structural determinants in domain II of human glutathione transferase M2-2 govern the characteristic activities with aminochrome, 2-cyano-1,3-dimethyl-1-nitrosoguanidine, and 1,2-dichloro-4-nitrobenzene.
Protein science : a publication of the Protein Society 1999;8(12):2742-50.
1999: Wisén S; Jiang F; Bergman B; Mannervik B
Expression and purification of the transcription factor NtcA from the cyanobacterium Anabaena PCC 7120.
Protein expression and purification 1999;17(3):351-7.
1999: Gustafsson A; Etahadieh M; Jemth P; Mannervik B
The C-terminal region of human glutathione transferase A1-1 affects the rate of glutathione binding and the ionization of the active-site Tyr9.
Biochemistry 1999;38(49):16268-75.
1999: Hansson L O; Widersten M; Mannervik B
An approach to optimizing the active site in a glutathione transferase by evolution in vitro.
The Biochemical journal 1999;344 Pt 1():93-100.
1999: Cameron A D; Ridderström M; Olin B; Kavarana M J; Creighton D J; Mannervik B
Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry 1999;38(41):13480-90.
1999: Johansson A S; Bolton-Grob R; Mannervik B
Use of silent mutations in cDNA encoding human glutathione transferase M2-2 for optimized expression in Escherichia coli.
Protein expression and purification 1999;17(1):105-12.
1999: Cameron A D; Ridderström M; Olin B; Mannervik B
Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure (London, England : 1993) 1999;7(9):1067-78.
1999: Dragani B; Cocco R; Ridderström M; Stenberg G; Mannervik B; Aceto A
Unfolding and refolding of human glyoxalase II and its single-tryptophan mutants.
Journal of molecular biology 1999;291(2):481-90.
1999: Jemth P; Mannervik B
Fast product formation and slow product release are important features in a hysteretic reaction mechanism of glutathione transferase T2-2.
Biochemistry 1999;38(31):9982-91.
1999: Danielson U H; Jiang F; Hansson L O; Mannervik B
Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site.
Biochemistry 1999;38(29):9254-63.
1999: Gustafsson A; Mannervik B
Benzoic acid derivatives induce recovery of catalytic activity in the partially inactive Met208Lys mutant of human glutathione transferase A1-1.
Journal of molecular biology 1999;288(4):787-800.
1999: Bruns C M; Hubatsch I; Ridderström M; Mannervik B; Tainer J A
Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products.
Journal of molecular biology 1999;288(3):427-39.
1999: Hansson L O; Bolton-Grob R; Massoud T; Mannervik B
Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling.
Journal of molecular biology 1999;287(2):265-76.
1999: Jiang F; Mannervik B
Optimized heterologous expression of glutathione reductase from Cyanobacterium anabaena PCC 7120 and characterization of the recombinant protein.
Protein expression and purification 1999;15(1):92-8.
1998: Sundberg K; Seidel A; Mannervik B; Jernström B
Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione.
FEBS letters 1998;438(3):206-10.
1998: Ridderström M; Cameron A D; Jones T A; Mannervik B
Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I.
The Journal of biological chemistry 1998;273(34):21623-8.
1998: Johansson A S; Stenberg G; Widersten M; Mannervik B
Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105.
Journal of molecular biology 1998;278(3):687-98.
1998: Mannervik B; Cameron A D; Fernandez E; Gustafsson A; Hansson L O; Jemth P; Jiang F; Jones T A; Larsson A K; Nilsson L O; Olin B; Pettersson P L; Ridderström M; Stenberg G; Widersten M
An evolutionary approach to the design of glutathione-linked enzymes.
Chemico-biological interactions 1998;111-112():15-21.
1998: Sundberg K; Johansson A S; Stenberg G; Widersten M; Seidel A; Mannervik B; Jernström B
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.
Carcinogenesis 1998;19(3):433-6.
1998: Hubatsch I; Ridderström M; Mannervik B
Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation.
The Biochemical journal 1998;330 ( Pt 1)():175-9.
1997: Jemth P; Mannervik B
Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme.
Archives of biochemistry and biophysics 1997;348(2):247-54.
1997: Sundberg K; Widersten M; Seidel A; Mannervik B; Jernström B
Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1-1 and P1-1.
Chemical research in toxicology 1997;10(11):1221-7.
1997: Ridderström M; Cameron A D; Jones T A; Mannervik B
Mutagenesis of residue 157 in the active site of human glyoxalase I.
The Biochemical journal 1997;328 ( Pt 1)():231-5.
1997: Jiang F; Mannervik B; Bergman B
Evidence for redox regulation of the transcription factor NtcA, acting both as an activator and a repressor, in the cyanobacterium Anabaena PCC 7120.
The Biochemical journal 1997;327 ( Pt 2)():513-7.
1997: Dragani B; Stenberg G; Melino S; Petruzzelli R; Mannervik B; Aceto A
The conserved N-capping box in the hydrophobic core of glutathione S-transferase P1-1 is essential for refolding. Identification of a buried and conserved hydrogen bond important for protein stability.
The Journal of biological chemistry 1997;272(41):25518-23.
1997: Hansson L O; Widersten M; Mannervik B
Mechanism-based phage display selection of active-site mutants of human glutathione transferase A1-1 catalyzing SNAr reactions.
Biochemistry 1997;36(37):11252-60.
1997: Dahl N; Pigg M; Ristoff E; Gali R; Carlsson B; Mannervik B; Larsson A; Board P
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction.
Human molecular genetics 1997;6(7):1147-52.
1997: Cameron A D; Olin B; Ridderström M; Mannervik B; Jones T A
Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping.
The EMBO journal 1997;16(12):3386-95.
1997: Baez S; Segura-Aguilar J; Widersten M; Johansson A S; Mannervik B
Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes.
The Biochemical journal 1997;324 ( Pt 1)():25-8.
1997: Ridderström M; Mannervik B
Molecular cloning and characterization of the thiolesterase glyoxalase II from Arabidopsis thaliana.
The Biochemical journal 1997;322 ( Pt 2)():449-54.
1997: Segura-Aguilar J; Baez S; Widersten M; Welch C J; Mannervik B
Human class Mu glutathione transferases, in particular isoenzyme M2-2, catalyze detoxication of the dopamine metabolite aminochrome.
The Journal of biological chemistry 1997;272(9):5727-31.
1996: Mannervik B
Evolution of glutathione transferases and related enzymes for the protection of cells against electrophiles.
Biochemical Society transactions 1996;24(3):878-80.
1996: Jernstrom B; Funk M; Frank H; Mannervik B; Seidel A
Glutathione S-transferase A1-1-catalysed conjugation of bay and fjord region diol epoxides or polycyclic aromatic hydrocarbons with glutathione.
Carcinogenesis 1996;17(7):1491-8.
1996: Widersten M; Huang M; Mannervik B
Optimized heterologous expression of the polymorphic human glutathione transferase M1-1 based on silent mutations in the corresponding cDNA.
Protein expression and purification 1996;7(4):367-72.
1996: Widersten M; Björnestedt R; Mannervik B
Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1.
Biochemistry 1996;35(24):7731-42.
1996: Jemth P; Stenberg G; Chaga G; Mannervik B
Heterologous expression, purification and characterization of rat class theta glutathione transferase T2-2.
The Biochemical journal 1996;316 ( Pt 1)():131-6.
1996: Ridderström M; Mannervik B
Optimized heterologous expression of the human zinc enzyme glyoxalase I.
The Biochemical journal 1996;314 ( Pt 2)():463-7.
1996: Ridderström M; Saccucci F; Hellman U; Bergman T; Principato G; Mannervik B
Molecular cloning, heterologous expression, and characterization of human glyoxalase II.
The Journal of biological chemistry 1996;271(1):319-23.
1996: Hansson J; Edgren M R; Egyházi S; Hao X Y; Mannervik B; Ringborg U
Increased cisplatin sensitivity of human fibroblasts from a subject with inherent glutathione deficiency.
Acta oncologica (Stockholm, Sweden) 1996;35(6):683-90.
1995: Björnestedt R; Tardioli S; Mannervik B
The high activity of rat glutathione transferase 8-8 with alkene substrates is dependent on a glycine residue in the active site.
The Journal of biological chemistry 1995;270(50):29705-9.
1995: Yilmaz S; Widersten M; Emahazion T; Mannervik B
Generation of a Ni(II) binding site by introduction of a histidine cluster in the structure of human glutathione transferase A1-1.
Protein engineering 1995;8(11):1163-9.
1995: Kolm R H; Danielson U H; Zhang Y; Talalay P; Mannervik B
Isothiocyanates as substrates for human glutathione transferases: structure-activity studies.
The Biochemical journal 1995;311 ( Pt 2)():453-9.
1995: Jiang F; Hellman U; Sroga G E; Bergman B; Mannervik B
Cloning, sequencing, and regulation of the glutathione reductase gene from the cyanobacterium Anabaena PCC 7120.
The Journal of biological chemistry 1995;270(39):22882-9.
1995: Cameron A D; Sinning I; L'Hermite G; Olin B; Board P G; Mannervik B; Jones T A
Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure (London, England : 1993) 1995;3(7):717-27.
1995: Widersten M; Mannervik B
Glutathione transferases with novel active sites isolated by phage display from a library of random mutants.
Journal of molecular biology 1995;250(2):115-22.
1995: Kolm R H; Stenberg G; Widersten M; Mannervik B
High-level bacterial expression of human glutathione transferase P1-1 encoded by semisynthetic DNA.
Protein expression and purification 1995;6(3):265-71.
1995: Björnestedt R; Stenberg G; Widersten M; Board P G; Sinning I; Jones T A; Mannervik B
Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1.
Journal of molecular biology 1995;247(4):765-73.
1995: Zhang Y; Kolm R H; Mannervik B; Talalay P
Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases.
Biochemical and biophysical research communications 1995;206(2):748-55.
1995: Berhane K; Hao X Y; Christensson B; Hansson J; Ringborg U; Mannervik B
The expression of glutathione transferase isoenzymes in human malignant lymphoma biopsies.
Acta oncologica (Stockholm, Sweden) 1995;34(1):35-41.
1995: Platz A; Jungnelius U; Grafström E; Lagerlöf B; Mannervik B; Ringborg U
Glutathione transferase P1-1 expression in human melanoma metastases: correlation to N-RAS mutations and expression.
Acta oncologica (Stockholm, Sweden) 1995;34(6):759-65.
1994: Widersten M; Björnestedt R; Mannervik B
Contribution of amino acid residue 208 in the hydrophobic binding site to the catalytic mechanism of human glutathione transferase A1-1.
Biochemistry 1994;33(39):11717-23.
1994: Chaga G; Widersten M; Andersson L; Porath J; Danielson U H; Mannervik B
Engineering of a metal coordinating site into human glutathione transferase M1-1 based on immobilized metal ion affinity chromatography of homologous rat enzymes.
Protein engineering 1994;7(9):1115-9.
1994: Hao X Y; Bergh J; Brodin O; Hellman U; Mannervik B
Acquired resistance to cisplatin and doxorubicin in a small cell lung cancer cell line is correlated to elevated expression of glutathione-linked detoxification enzymes.
Carcinogenesis 1994;15(6):1167-73.
1994: Jungnelius U; Ridderström M; Hansson J; Ringborg U; Mannervik B
Similar toxic effect of 1,3-bis(2-chloroethyl)-1-nitrosourea on lymphocytes from human subjects differing in the expression of glutathione transferase M1-1.
Biochemical pharmacology 1994;47(10):1777-80.
1994: Berhane K; Widersten M; Engström A; Kozarich J W; Mannervik B
Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1480-4.
1994: Jungnelius U; Hao X Y; Skog S; Castro V M; Mannervik B; Ringborg U
Cell cycle dependent sensitivity of human melanoma cells to melphalan is correlated with the activity and cellular concentration of glutathione transferases.
Carcinogenesis 1994;15(1):99-103.
1994: Hao X Y; Castro V M; Bergh J; Sundström B; Mannervik B
Isoenzyme-specific quantitative immunoassays for cytosolic glutathione transferases and measurement of the enzymes in blood plasma from cancer patients and in tumor cell lines.
Biochimica et biophysica acta 1994;1225(2):223-30.
1994: Hao X Y; Widersten M; Ridderström M; Hellman U; Mannervik B
Co-variation of glutathione transferase expression and cytostatic drug resistance in HeLa cells: establishment of class Mu glutathione transferase M3-3 as the dominating isoenzyme.
The Biochemical journal 1994;297 ( Pt 1)():59-67.
1993: Berhane K; Hao X Y; Egyházi S; Hansson J; Ringborg U; Mannervik B
Contribution of glutathione transferase M3-3 to 1,3-bis(2-chloroethyl)-1-nitrosourea resistance in a human non-small cell lung cancer cell line.
Cancer research 1993;53(18):4257-61.
1993: Mannervik B; Ridderström M
Catalytic and molecular properties of glyoxalase I.
Biochemical Society transactions 1993;21(2):515-7.
1993: Klinga-Levan K; Andersson A; Hanson C; Ridderström M; Stenberg G; Mannervik B; Vajdy M; Szpirer J; Szpirer C; Levan G
Mapping of glutathione transferase (GST) genes in the rat.
Hereditas 1993;119(3):285-96.
1992: Widersten M; Mannervik B
A structural role of histidine 15 in human glutathione transferase M1-1, an amino acid residue conserved in class Mu enzymes.
Protein engineering 1992;5(6):551-7.
1992: Staffas L; Mankowitz L; Söderström M; Blanck A; Porsch-Hällström I; Sundberg C; Mannervik B; Olin B; Rydström J; DePierre J W
Further characterization of hormonal regulation of glutathione transferase in rat liver and adrenal glands. Sex differences and demonstration that growth hormone regulates the hepatic levels.
The Biochemical journal 1992;286 ( Pt 1)():65-72.
1992: Kolm R H; Sroga G E; Mannervik B
Participation of the phenolic hydroxyl group of Tyr-8 in the catalytic mechanism of human glutathione transferase P1-1.
The Biochemical journal 1992;285 ( Pt 2)():537-40.
1992: Widersten M; Kolm R H; Björnestedt R; Mannervik B
Contribution of five amino acid residues in the glutathione-binding site to the function of human glutathione transferase P1-1.
The Biochemical journal 1992;285 ( Pt 2)():377-81.
1992: Stenberg G; Ridderström M; Engström A; Pemble S E; Mannervik B
Cloning and heterologous expression of cDNA encoding class alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic alpha,beta-unsaturated carbonyl compounds.
The Biochemical journal 1992;284 ( Pt 2)():313-9.
1992: Söderström M; Mannervik B; Garkov V; Hammarström S
On the nature of leukotriene C4 synthase in human platelets.
Archives of biochemistry and biophysics 1992;294(1):70-4.
1992: Björnestedt R; Widersten M; Board P G; Mannervik B
Design of two chimaeric human-rat class alpha glutathione transferases for probing the contribution of C-terminal segments of protein structure to the catalytic properties.
The Biochemical journal 1992;282 ( Pt 2)():505-10.
1992: Stenberg G; Björnestedt R; Mannervik B
Heterologous expression of recombinant human glutathione transferase A1-1 from a hepatoma cell line.
Protein expression and purification 1992;3(1):80-4.
1991: Mankowitz L; DePierre J W; Mannervik B; Hansson H A
Immunohistochemical distribution of isoenzymes of glutathione transferase in adult rat adrenal gland before and after hypophysectomy.
The Biochemical journal 1991;280 ( Pt 2)():399-405.
1991: Widersten M; Holmström E; Mannervik B
Cysteine residues are not essential for the catalytic activity of human class Mu glutathione transferase M1a-1a.
FEBS letters 1991;293(1-2):156-9.
1991: Stenberg G; Board P G; Mannervik B
Mutation of an evolutionarily conserved tyrosine residue in the active site of a human class Alpha glutathione transferase.
FEBS letters 1991;293(1-2):153-5.
1991: Widersten M; Pearson W R; Engström A; Mannervik B
Heterologous expression of the allelic variant mu-class glutathione transferases mu and psi.
The Biochemical journal 1991;276 ( Pt 2)():519-24.
1991: Stenberg G; Board P G; Carlberg I; Mannervik B
Effects of directed mutagenesis on conserved arginine residues in a human Class Alpha glutathione transferase.
The Biochemical journal 1991;274 ( Pt 2)():549-55.
1991: Sellin S; Holmquist B; Mannervik B; Vallee B L
Oxidation and reduction of 4-hydroxyalkenals catalyzed by isozymes of human alcohol dehydrogenase.
Biochemistry 1991;30(9):2514-8.
1991: Hansson J; Berhane K; Castro V M; Jungnelius U; Mannervik B; Ringborg U
Sensitization of human melanoma cells to the cytotoxic effect of melphalan by the glutathione transferase inhibitor ethacrynic acid.
Cancer research 1991;51(1):94-8.
1990: Castro V M; Söderström M; Carlberg I; Widersten M; Platz A; Mannervik B
Differences among human tumor cell lines in the expression of glutathione transferases and other glutathione-linked enzymes.
Carcinogenesis 1990;11(9):1569-76.
1990: Berhane K; Mannervik B
Inactivation of the genotoxic aldehyde acrolein by human glutathione transferases of classes alpha, mu, and pi.
Molecular pharmacology 1990;37(2):251-4.
1990: Mankowitz L; Castro V M; Mannervik B; Rydström J; DePierre J W
Increase in the amount of glutathione transferase 4-4 in the rat adrenal gland after hypophysectomy and down-regulation by subsequent treatment with adrenocorticotrophic hormone.
The Biochemical journal 1990;265(1):147-54.
1990: Mannervik B; Berhane K; Castro V M; Olin B; Ridderström M; Vignani R; Kozarich J W; Ringborg U
Glutathione-linked enzymes in normal and tumor cells and their role in resistance against genotoxic agents.
Princess Takamatsu symposia 1990;21():253-62.
1989: Cowan S W; Bergfors T; Jones T A; Tibbelin G; Olin B; Board P G; Mannervik B
Crystallization of GST2, a human class alpha glutathione transferase.
Journal of molecular biology 1989;208(2):369-70.
1988: Mannervik B; Danielson U H
Glutathione transferases--structure and catalytic activity.
CRC critical reviews in biochemistry 1988;23(3):283-337.

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