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James Manning

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James M Manning; Julio C Padovan; Anthony Popowicz; Brian T Chait; Lois R Manning
Intrinsic regulation of hemoglobin expression by variable subunit interface strengths.
Lois R Manning; Anthony Popowicz; Julio Padovan; Brian T Chait; J Eric Russell; James M Manning
Developmental expression of human hemoglobins mediated by maturation of their subunit interfaces.
Bryan W Lepore; Dali Liu; Ying Peng; Mengmeng Fu; Chad Yasuda; James M Manning; Richard B Silverman; Dagmar Ringe
Chiral discrimination among aminotransferases: inactivation by 4-amino-4,5-dihydrothiophenecarboxylic acid.

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All Publications

2012: James M Manning; Julio C Padovan; Anthony Popowicz; Brian T Chait; Lois R Manning
Intrinsic regulation of hemoglobin expression by variable subunit interface strengths.
The FEBS journal 2012;279(3):361-9.
2010: Lois R Manning; Anthony Popowicz; Julio Padovan; Brian T Chait; J Eric Russell; James M Manning
Developmental expression of human hemoglobins mediated by maturation of their subunit interfaces.
Protein science : a publication of the Protein Society 2010;19(8):1595-9.
2010: Bryan W Lepore; Dali Liu; Ying Peng; Mengmeng Fu; Chad Yasuda; James M Manning; Richard B Silverman; Dagmar Ringe
Chiral discrimination among aminotransferases: inactivation by 4-amino-4,5-dihydrothiophenecarboxylic acid.
Biochemistry 2010;49(14):3138-47.
2009: Lois R Manning; J Eric Russell; Anthony Popowicz; Robert S Manning; Julio C Padovan; James M Manning
Energetic differences at the subunit interfaces of normal human hemoglobins correlate with their developmental profile.
Biochemistry 2009;48(32):7568-74.
2007: Lois R Manning; J Eric Russell; Julio C Padovan; Brian T Chait; Anthony Popowicz; Robert S Manning; James M Manning
Human embryonic, fetal, and adult hemoglobins have different subunit interface strengths. Correlation with lifespan in the red cell.
Protein science : a publication of the Protein Society 2007;16(8):1641-58.
2005: Makoto Ashiuchi; Takeshi Yagami; Ronald J Willey; Julio C Padovan; Brian T Chait; Anthony Popowicz; Lois R Manning; James M Manning
N-terminal acetylation and protonation of individual hemoglobin subunits: position-dependent effects on tetramer strength and cooperativity.
Protein science : a publication of the Protein Society 2005;14(6):1458-71.
2004: Alon Geva; Jennifer J Clark; Yuxun Zhang; Anthony Popowicz; James M Manning; Ellis J Neufeld
Hemoglobin Jamaica plain--a sickling hemoglobin with reduced oxygen affinity.
The New England journal of medicine 2004;351(15):1532-8.
2003: Yuxun Zhang; Lois R Manning; Jill Falcone; Orah Platt; James M Manning
Human erythrocyte membrane band 3 protein influences hemoglobin cooperativity. Possible effect on oxygen transport.
The Journal of biological chemistry 2003;278(41):39565-71.
2002: Xianfeng Li; Robin W Briehl; Robert M Bookchin; Robert Josephs; Baoyang Wei; James M Manning; Frank A Ferrone
Sickle hemoglobin polymer stability probed by triple and quadruple mutant hybrids.
The Journal of biological chemistry 2002;277(16):13479-87.
2002: Takeshi Yagami; Barry T Ballard; Julio C Padovan; Brian T Chait; Anthony Popowicz; James M Manning
N-terminal contributions of the gamma-subunit of fetal hemoglobin to its tetramer strength: remote effects at subunit contacts.
Protein science : a publication of the Protein Society 2002;11(1):27-35.
2001: K Kishimoto; James M Manning
Adherence of vancomycin to proteins.
Journal of protein chemistry 2001;20(6):455-61.
2001: Lois R Manning; James M Manning
The acetylation state of human fetal hemoglobin modulates the strength of its subunit interactions: long-range effects and implications for histone interactions in the nucleosome.
Biochemistry 2001;40(6):1635-9.
2000: K Inagaki; J Inagaki; A Dumoulin; Julio C Padovan; Brian T Chait; Anthony Popowicz; Lois R Manning; James M Manning
Expression and properties of recombinant HbA2 (alpha2delta2) and hybrids containing delta-beta sequences.
Journal of protein chemistry 2000;19(8):649-62.
2000: DA Bulik; PW van Ophem; James M Manning; Z Shen; David S Newburg; Edward L Jarroll
UDP-N-acetylglucosamine pyrophosphorylase, a key enzyme in encysting Giardia, is allosterically regulated.
The Journal of biological chemistry 2000;275(19):14722-8.
2000: W Chen; A Dumoulin; Xianfeng Li; Julio C Padovan; Brian T Chait; R Buonopane; Orah Platt; Lois R Manning; James M Manning
Transposing sequences between fetal and adult hemoglobins indicates which subunits and regulatory molecule interfaces are functionally related.
Biochemistry 2000;39(13):3774-81.
2000: K Kishimoto; C Yasuda; James M Manning
Reversible dissociation/association of D-amino acid transaminase subunits: properties of isolated active dimers and inactive monomers.
Biochemistry 2000;39(2):381-7.
1999: James M Manning; A Dumoulin; Lois R Manning; W Chen; Julio C Padovan; Brian T Chait; Anthony Popowicz
Remote contributions to subunit interactions: lessons from adult and fetal hemoglobins.
Trends in biochemical sciences 1999;24(6):211-2.
1999: Xianfeng Li; Juha P Himanen; J J Martin de Llano; Julio C Padovan; Brian T Chait; James M Manning
Mutational analysis of sickle haemoglobin (Hb) gelation.
Biotechnology and applied biochemistry 1999;29 ( Pt 2)():165-84.
1999: PW van Ophem; D Peisach; S D Erickson; K Soda; Dagmar Ringe; James M Manning
Effects of the E177K mutation in D-amino acid transaminase. Studies on an essential coenzyme anchoring group that contributes to stereochemical fidelity.
Biochemistry 1999;38(4):1323-31.
1999: Lois R Manning; A Dumoulin; W T Jenkins; RM Winslow; James M Manning
Determining subunit dissociation constants in natural and recombinant proteins.
Methods in enzymology 1999;306():113-29.
1998: A Dumoulin; Julio C Padovan; Lois R Manning; Anthony Popowicz; RM Winslow; Brian T Chait; James M Manning
The N-terminal sequence affects distant helix interactions in hemoglobin. Implications for mutant proteins from studies on recombinant hemoglobin felix.
The Journal of biological chemistry 1998;273(52):35032-8.
1998: James M Manning; A Dumoulin; Xianfeng Li; Lois R Manning
Normal and abnormal protein subunit interactions in hemoglobins.
The Journal of biological chemistry 1998;273(31):19359-62.
1998: D Peisach; D M Chipman; PW van Ophem; James M Manning; Dagmar Ringe
Crystallographic study of steps along the reaction pathway of D-amino acid aminotransferase.
Biochemistry 1998;37(14):4958-67.
1998: PW van Ophem; S D Erickson; A Martinez del Pozo; Ivan Haller; Brian T Chait; T Yoshimura; K Soda; Dagmar Ringe; G Petsko; James M Manning
Substrate inhibition of D-amino acid transaminase and protection by salts and by reduced nicotinamide adenine dinucleotide: isolation and initial characterization of a pyridoxo intermediate related to inactivation.
Biochemistry 1998;37(9):2879-88.
1997: A Dumoulin; Lois R Manning; W T Jenkins; RM Winslow; James M Manning
Exchange of subunit interfaces between recombinant adult and fetal hemoglobins. Evidence for a functional inter-relationship among regions of the tetramer.
The Journal of biological chemistry 1997;272(50):31326-32.
1997: Xianfeng Li; U A Mirza; Brian T Chait; James M Manning
Systematic enhancement of polymerization of recombinant sickle hemoglobin mutants: implications for transgenic mouse model for sickle cell anemia.
Blood 1997;90(11):4620-7.
1997: Juha P Himanen; Anthony Popowicz; James M Manning
Recombinant sickle hemoglobin containing a lysine substitution at Asp-85(alpha): expression in yeast, functional properties, and participation in gel formation.
Blood 1997;89(11):4196-203.
1997: Z Cao; D Liao; R Mirchev; J J Martin de Llano; Juha P Himanen; James M Manning; Frank A Ferrone
Nucleation and polymerization of sickle hemoglobin with Leu beta 88 substituted by Ala.
Journal of molecular biology 1997;265(5):580-9.
1996: W M Jones; PW van Ophem; M A Pospischil; Dagmar Ringe; Gregory A Petsko; K Soda; James M Manning
The ubiquitous cofactor NADH protects against substrate-induced inhibition of a pyridoxal enzyme.
Protein science : a publication of the Protein Society 1996;5(12):2545-51.
1996: Juha P Himanen; U A Mirza; Brian T Chait; R M Bookchin; James M Manning
A recombinant sickle hemoglobin triple mutant with independent inhibitory effects on polymerization.
The Journal of biological chemistry 1996;271(41):25152-6.
1996: D Liao; J J Martin de Llano; Juha P Himanen; James M Manning; Frank A Ferrone
Solubility of sickle hemoglobin measured by a kinetic micromethod.
Biophysical journal 1996;70(5):2442-7.
1996: Lois R Manning; W T Jenkins; John R Hess; Kim Vandegriff; Robert M Winslow; James M Manning
Subunit dissociations in natural and recombinant hemoglobins.
Protein science : a publication of the Protein Society 1996;5(4):775-81.
1996: A Martinez del Pozo; PW van Ophem; Dagmar Ringe; Gregory A Petsko; K Soda; James M Manning
Interaction of pyridoxal 5'-phosphate with tryptophan-139 at the subunit interface of dimeric D-amino acid transaminase.
Biochemistry 1996;35(7):2112-6.
1996: James M Manning
Examples of chemical modification and recombinant DNA approaches with hemoglobin.
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 1996;3(2):109-11.
1995: PW van Ophem; M A Pospischil; Dagmar Ringe; D Peisach; Gregory A Petsko; K Soda; James M Manning
Catalytic ability and stability of two recombinant mutants of D-amino acid transaminase involved in coenzyme binding.
Protein science : a publication of the Protein Society 1995;4(12):2578-86.
1995: S Sugio; Gregory A Petsko; James M Manning; K Soda; Dagmar Ringe
Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity.
Biochemistry 1995;34(30):9661-9.
1995: Juha P Himanen; K Schneider; Brian T Chait; James M Manning
Participation and strength of interaction of lysine 95(beta) in the polymerization of hemoglobin S as determined by its site-directed substitution by isoleucine.
The Journal of biological chemistry 1995;270(23):13885-91.
1995: H Yanase; Lois R Manning; Kim Vandegriff; Robert M Winslow; James M Manning
A recombinant human hemoglobin with asparagine-102(beta) substituted by alanine has a limiting low oxygen affinity, reduced marginally by chloride.
Protein science : a publication of the Protein Society 1995;4(1):21-8.
1994: H Yanase; Sean M Cahill; J J Martin de Llano; Lois R Manning; K Schneider; Brian T Chait; Kim Vandegriff; Robert M Winslow; James M Manning
Properties of a recombinant human hemoglobin with aspartic acid 99(beta), an important intersubunit contact site, substituted by lysine.
Protein science : a publication of the Protein Society 1994;3(8):1213-23.
1994: J J Martin de Llano; James M Manning
Properties of a recombinant human hemoglobin double mutant: sickle hemoglobin with Leu-88(beta) at the primary aggregation site substituted by Ala.
Protein science : a publication of the Protein Society 1994;3(8):1206-12.
1994: Andrea Scaloni; Donatella Barra; W M Jones; James M Manning
Human acylpeptide hydrolase. Studies on its thiol groups and mechanism of action.
The Journal of biological chemistry 1994;269(21):15076-84.
1994: W M Jones; Dagmar Ringe; K Soda; James M Manning
Determination of free D-amino acids with a bacterial transaminase: their depletion leads to inhibition of bacterial growth.
Analytical biochemistry 1994;218(1):204-9.
1994: James M Manning
Random chemical modification of hemoglobin to identify chloride binding sites in the central dyad axis: their role in control of oxygen affinity.
Artificial cells, blood substitutes, and immobilization biotechnology 1994;22(2):199-205.
1994: J J Martin de Llano; Olaf Schneewind; G L Stetler; James M Manning
Purification and characterization of recombinant human sickle hemoglobin expressed in yeast.
Methods in enzymology 1994;231():390-403.
1994: James M Manning
Preparation of hemoglobin derivatives selectively or randomly modified at amino groups.
Methods in enzymology 1994;231():225-46.
1994: W M Jones; Andrea Scaloni; James M Manning
Acylaminoacyl-peptidase.
Methods in enzymology 1994;244():227-31.
1993: J J Martin de Llano; W Jones; K Schneider; Brian T Chait; James M Manning; G Rodgers; L J Benjamin; B Weksler
Biochemical and functional properties of recombinant human sickle hemoglobin expressed in yeast.
The Journal of biological chemistry 1993;268(36):27004-11.
1993: M Feese; Andrea Scaloni; W M Jones; James M Manning; S James Remington
Crystallization and preliminary X-ray studies of human erythrocyte acylpeptide hydrolase.
Journal of molecular biology 1993;233(3):546-9.
1993: H Ueno; Anthony Popowicz; James M Manning
Random chemical modification of the oxygen-linked chloride-binding sites of hemoglobin: those in the central dyad axis may influence the transition between deoxy- and oxy-hemoglobin.
Journal of protein chemistry 1993;12(5):561-70.
1993: M B Bhatia; A Martinez del Pozo; Dagmar Ringe; T Yoshimura; K Soda; James M Manning
Role reversal for substrates and inhibitors. Slow inactivation of D-amino acid transaminase by its normal substrates and protection by inhibitors.
The Journal of biological chemistry 1993;268(24):17687-94.
1993: James M Manning
The contributions of Stein and Moore to protein science.
Protein science : a publication of the Protein Society 1993;2(7):1188-91.
1993: M B Bhatia; S Futaki; H Ueno; James M Manning; Dagmar Ringe; T Yoshimura; K Soda
Kinetic and stereochemical comparison of wild-type and active-site K145Q mutant enzyme of bacterial D-amino acid transaminase.
The Journal of biological chemistry 1993;268(10):6932-8.
1993: J J Martin de Llano; Olaf Schneewind; G Stetler; James M Manning
Recombinant human sickle hemoglobin expressed in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(3):918-22.
1992: T Yoshimura; M B Bhatia; James M Manning; Dagmar Ringe; K Soda
Partial reactions of bacterial D-amino acid transaminase with asparagine substituted for the lysine that binds coenzyme pyridoxal 5'-phosphate.
Biochemistry 1992;31(47):11748-54.
1992: Andrea Scaloni; W Jones; M Pospischil; Shigeru Sassa; Olaf Schneewind; Anthony Popowicz; F Bossa; S L Graziano; James M Manning
Deficiency of acylpeptide hydrolase in small-cell lung carcinoma cell lines.
The Journal of laboratory and clinical medicine 1992;120(4):546-52.
1992: A Martinez del Pozo; T Yoshimura; M B Bhatia; S Futaki; James M Manning; Dagmar Ringe; K Soda
Inactivation of dimeric D-amino acid transaminase by a normal substrate through formation of an unproductive coenzyme adduct in one subunit.
Biochemistry 1992;31(26):6018-23.
1992: H Ueno; E Yatco; L J Benjamin; James M Manning
Effects of methyl acetyl phosphate, a covalent antisickling agent, on the density profiles of sickle erythrocytes.
The Journal of laboratory and clinical medicine 1992;120(1):152-8.
1992: H Ueno; James M Manning
The functional, oxygen-linked chloride binding sites of hemoglobin are contiguous within a channel in the central cavity.
Journal of protein chemistry 1992;11(2):177-85.
1992: M Moriguchi; Lois R Manning; James M Manning
Nitric oxide can modify amino acid residues in proteins.
Biochemical and biophysical research communications 1992;183(2):598-604.
1992: Andrea Scaloni; W M Jones; Donatella Barra; M Pospischil; Shigeru Sassa; Anthony Popowicz; Lois R Manning; Olaf Schneewind; James M Manning
Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme.
The Journal of biological chemistry 1992;267(6):3811-8.
1991: Lois R Manning; S Morgan; Ronald C Beavis; Brian T Chait; James M Manning; John R Hess; M Cross; D L Currell; M A Marini; Robert M Winslow
Preparation, properties, and plasma retention of human hemoglobin derivatives: comparison of uncrosslinked carboxymethylated hemoglobin with crosslinked tetrameric hemoglobin.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3329-33.
1991: W M Jones; Andrea Scaloni; F Bossa; Anthony Popowicz; Olaf Schneewind; James M Manning
Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2194-8.
1991: James M Manning
Covalent inhibitors of the gelation of sickle cell hemoglobin and their effects on function.
Advances in enzymology and related areas of molecular biology 1991;64():55-91.
1990: S Futaki; H Ueno; A Martinez del Pozo; M A Pospischil; James M Manning; Dagmar Ringe; B Stoddard; K Tanizawa; T Yoshimura; K Soda
Substitution of glutamine for lysine at the pyridoxal phosphate binding site of bacterial D-amino acid transaminase. Effects of exogenous amines on the slow formation of intermediates.
The Journal of biological chemistry 1990;265(36):22306-12.
1990: Lois R Manning; W J Fantl; James M Manning
Functional measurements on carboxymethylated hemoglobin, a potential blood substitute: effects of sodium chloride on pH values that influence the alkaline Bohr effect.
Biomaterials, artificial cells, and artificial organs 1990;18(2):133-41.
1989: A Martinez del Pozo; M A Pospischil; H Ueno; James M Manning; K Tanizawa; K Nishimura; K Soda; Dagmar Ringe; B Stoddard; Gregory A Petsko
Effects of D-serine on bacterial D-amino acid transaminase: accumulation of an intermediate and inactivation of the enzyme.
Biochemistry 1989;28(22):8798-803.
1989: A Martínez del Pozo; M Merola; H Ueno; James M Manning; K Tanizawa; K Nishimura; K Soda; Dagmar Ringe
Stereospecificity of reactions catalyzed by bacterial D-amino acid transaminase.
The Journal of biological chemistry 1989;264(30):17784-9.
1989: H Ueno; M A Pospischil; James M Manning
Methyl acetyl phosphate as a covalent probe for anion-binding sites in human and bovine hemoglobins.
The Journal of biological chemistry 1989;264(21):12344-51.
1989: N Mori; Y Bai; H Ueno; James M Manning
Sequence-dependent reactivity of model peptides with glyceraldehyde.
Carbohydrate research 1989;189():49-63.
1989: Y Bai; H Ueno; James M Manning
Some factors that influence the nonenzymatic glycation of peptides and polypeptides by glyceraldehyde.
Journal of protein chemistry 1989;8(2):299-315.
1989: A Martinez del Pozo; H Ueno; M Merola; C Danzin; James M Manning
gamma-Acetylenic-gamma-aminobutyrate as an enzyme-activated inhibitor of D-amino acid transaminase.
Biochimie 1989;71(4):505-8.
1989: A Martínez del Pozo; M Merola; H Ueno; James M Manning; K Tanizawa; K Nishimura; S Asano; H Tanaka; K Soda; Dagmar Ringe
Activity and spectroscopic properties of bacterial D-amino acid transaminase after multiple site-directed mutagenesis of a single tryptophan residue.
Biochemistry 1989;28(2):510-6.
1989: M Merola; A Martínez del Pozo; H Ueno; P Recsei; Alberto Di Donato; James M Manning; K Tanizawa; Y Masu; S Asano; H Tanaka
Site-directed mutagenesis of the cysteinyl residues and the active-site serine residue of bacterial D-amino acid transaminase.
Biochemistry 1989;28(2):505-9.
1989: H Ueno; Y Bai; James M Manning
Covalent chemical modifiers of sickle cell hemoglobin.
Annals of the New York Academy of Sciences 1989;565():239-46.
1988: Lois R Manning; James M Manning
Influence of ligation state and concentration of hemoglobin A on its cross-linking by glycolaldehyde: functional properties of cross-linked, carboxymethylated hemoglobin.
Biochemistry 1988;27(17):6640-4.
1988: W M Jones; James M Manning
Substrate specificity of an acylaminopeptidase that catalyzes the cleavage of the blocked amino termini of peptides.
Biochimica et biophysica acta 1988;953(3):357-60.
1988: H Ueno; James M Manning
Methyl acetyl phosphate, a new type of antisickling agent: site-specific acetylating agent toward the 2,3-DPG binding site in hemoglobin S.
The American journal of pediatric hematology/oncology 1988;10(4):348-50.
1987: W J Fantl; Alberto Di Donato; James M Manning; Paul H Rogers; Arthur Arnone
Specifically carboxymethylated hemoglobin as an analogue of carbamino hemoglobin. Solution and X-ray studies of carboxymethylated hemoglobin and X-ray studies of carbamino hemoglobin.
The Journal of biological chemistry 1987;262(26):12700-13.
1987: W J Fantl; Lois R Manning; H Ueno; Alberto Di Donato; James M Manning
Properties of carboxymethylated cross-linked hemoglobin A.
Biochemistry 1987;26(18):5755-61.
1986: W M Jones; Lois R Manning; James M Manning
Enzymic cleavage of the blocked amino terminal residues of peptides.
Biochemical and biophysical research communications 1986;139(1):244-50.