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Pekka Männistö

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
22
Venäläinen, Jarkko
19
Forsberg, Markus
19
Tuominen, Raimo
18
Vasar, Eero
16
Raasmaja, Atso
13
Huotari, Marko
12
Kaakkola, Seppo
12
Gynther, Jukka
12
Wallén, Erik
11
Volke, Vallo
11
Christiaans, Johannes
11
Kõks, Sulev
10
Karayiorgou, Maria
10
Bourin, Michel
9
Gogos, Joseph

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Publications

TOP 3
Suzuki Go; Harper Kathryn M; Hiramoto Takeshi; Funke Birgit; Lee MoonSook; Kang Gina; Buell Mahalah; Geyer Mark A; Kucherlapati Raju; Morrow Bernice; Männistö Pekka T; Agatsuma Soh; Hiroi Noboru
Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice.
Piltonen Marjo; Bespalov Maxim M; Ervasti Dagmar; Matilainen Tero; Sidorova Yulia A; Rauvala Heikki; Saarma Mart; Männistö Pekka T
Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons.
Tenorio-Laranga Jofre; Valero M Luz; Männistö Pekka T; Sánchez del Pino Manuel; García-Horsman J Arturo
Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain.

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All Publications

2009: Suzuki Go; Harper Kathryn M; Hiramoto Takeshi; Funke Birgit; Lee MoonSook; Kang Gina; Buell Mahalah; Geyer Mark A; Kucherlapati Raju; Morrow Bernice; Männistö Pekka T; Agatsuma Soh; Hiroi Noboru
Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice.
Human molecular genetics 2009;18(20):3914-25.
2009: Piltonen Marjo; Bespalov Maxim M; Ervasti Dagmar; Matilainen Tero; Sidorova Yulia A; Rauvala Heikki; Saarma Mart; Männistö Pekka T
Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons.
Experimental neurology 2009;219(2):499-506.
2009: Tenorio-Laranga Jofre; Valero M Luz; Männistö Pekka T; Sánchez del Pino Manuel; García-Horsman J Arturo
Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain.
Analytical biochemistry 2009;393(1):80-7.
2009: Myöhänen Timo T; García-Horsman J Arturo; Tenorio-Laranga Jofre; Männistö Pekka T
Issues about the physiological functions of prolyl oligopeptidase based on its discordant spatial association with substrates and inconsistencies among mRNA, protein levels, and enzymatic activity.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009;57(9):831-48.
2009: Ossola Bernardino; Kääriäinen Tiina M; Männistö Pekka T
The multiple faces of quercetin in neuroprotection.
Expert opinion on drug safety 2009;8(4):397-409.
2009: Tenorio-Laranga Jofre; Männistö Pekka T; Karayiorgou Maria; Gogos Joseph A; García-Horsman J Arturo
Sex-dependent compensated oxidative stress in the mouse liver upon deletion of catechol O-methyltransferase.
Biochemical pharmacology 2009;77(9):1541-52.
2009: Lehtonen Sárka; Männistö Pekka T; Raasmaja Atso
Expression of tyrosine hydroxylase in the striatum of atipamezole-treated rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;36(4-5):602-4.
2009: Kääriäinen Tiina M; García-Horsman Juan Arturo; Piltonen Marjo; Männistö Pekka T
L-dopa-induced desensitization depends on 5-hydroxytryptamine imbalance in hemiparkinsonian rats.
Neuroreport 2009;20(3):313-8.
2009: Myöhänen Timo T; Kääriäinen Tiina M; Jalkanen Aaro J; Piltonen Marjo; Männistö Pekka T
Localization of prolyl oligopeptidase in the thalamic and cortical projection neurons: a retrograde neurotracing study in the rat brain.
Neuroscience letters 2009;450(2):201-5.
2009: Hanzlíková Martina; Soininen Päivi; Lampela Pasi; Männistö Pekka T; Raasmaja Atso
The role of PEI structure and size in the PEI/liposome-mediated synergism of gene transfection.
Plasmid 2009;61(1):15-21.
2008: Myöhänen Timo T; Venäläinen Jarkko I; García-Horsman J Arturo; Piltonen Marjo; Männistö Pekka T
Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues.
Histochemistry and cell biology 2008;130(5):993-1003.
2008: Kambur Oleg; Männistö Pekka T; Viljakka Kaarin; Reenilä Ilkka; Lemberg Kim; Kontinen Vesa K; Karayiorgou Maria; Gogos Joseph A; Kalso Eija
Stress-induced analgesia and morphine responses are changed in catechol-O-methyltransferase-deficient male mice.
Basic & clinical pharmacology & toxicology 2008;103(4):367-73.
2008: Tammimäki Anne; Forsberg Markus M; Karayiorgou Maria; Gogos Joseph A; Männistö Pekka T
Increase in free choice oral ethanol self-administration in catechol-o-methyltransferase gene-disrupted male mice.
Basic & clinical pharmacology & toxicology 2008;103(4):297-304.
2008: Tenorio-Laranga Jofre; Venäläinen Jarkko I; Männistö Pekka T; García-Horsman J A
Characterization of membrane-bound prolyl endopeptidase from brain.
The FEBS journal 2008;275(17):4415-27.
2008: Tammimäki Anne; Chistyakov Vladimir; Patkina Nadezhda; Skippari Johanna; Ahtee Liisa; Zvartau Edwin; Männistö Pekka T
Effect of forced chronic oral nicotine exposure on intravenous self-administration and rewarding properties of acute nicotine.
European journal of pharmacology 2008;591(1-3):164-70.
2008: Ossola Bernardino; Kääräinen Tiina M; Raasmaja Atso; Männistö Pekka T
Time-dependent protective and harmful effects of quercetin on 6-OHDA-induced toxicity in neuronal SH-SY5Y cells.
Toxicology 2008;250(1):1-8.
2008: Myöhänen T T; Venäläinen J I; Garcia-Horsman J A; Männistö P T
Spatial association of prolyl oligopeptidase, inositol 1,4,5-triphosphate type 1 receptor, substance P and its neurokinin-1 receptor in the rat brain: an immunohistochemical colocalization study.
Neuroscience 2008;153(4):1177-89.
2008: Kääriäinen Tiina M; Piltonen Marjo; Ossola Bernardino; Kekki Heli; Lehtonen Sárka; Nenonen Terhi; Lecklin Anne; Raasmaja Atso; Männistö Pekka T
Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures.
Brain research 2008;1203():149-59.
2008: Myöhänen Timo T; Venäläinen Jarkko I; Garcia-Horsman J Arturo; Piltonen Marjo; Männistö Pekka T
Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters.
The Journal of comparative neurology 2008;507(5):1694-708.
2008: Kääriäinen Tiina M; García-Horsman J Arturo; Piltonen Marjo; Huotari Marko; Männistö Pekka T
Serotonergic activation after 2-week intrastriatal infusion of L-dopa and slow recovery of circling in rats with unilateral nigral lesions.
Basic & clinical pharmacology & toxicology 2008;102(3):300-7.
2008: Puttonen Katja A; Lehtonen Sárka; Lampela Pasi; Männistö Pekka T; Raasmaja Atso
Different viabilities and toxicity types after 6-OHDA and Ara-C exposure evaluated by four assays in five cell lines.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(1):182-9.
2008: Kääriäinen Tiina M; Lehtonen Marko; Forsberg Markus M; Savolainen Jouko; Käenmäki Mikko; Männistö Pekka T
Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats.
Basic & clinical pharmacology & toxicology 2008;102(1):50-8.
2007: Rantamäki Tomi; Hendolin Panu; Kankaanpää Aino; Mijatovic Jelena; Piepponen Petteri; Domenici Enrico; Chao Moses V; Männistö Pekka T; Castrén Eero
Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(10):2152-62.
2007: Yavich Leonid; Forsberg Markus M; Karayiorgou Maria; Gogos Joseph A; Männistö Pekka T
Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(38):10196-209.
2007: Myöhänen Timo T; Venäläinen Jarkko I; Tupala Erkki; Garcia-Horsman J Arturo; Miettinen Riitta; Männistö Pekka T
Distribution of immunoreactive prolyl oligopeptidase in human and rat brain.
Neurochemical research 2007;32(8):1365-74.
2007: Garcia-Horsman J Arturo; Venäläinen Jarkko I; Lohi Olli; Auriola I Seppo; Korponay-Szabo Ilma R; Kaukinen Katri; Mäki Markku; Männistö Pekka T
Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease.
Scandinavian journal of gastroenterology 2007;42(5):562-71.
2007: Jarho Elina M; Venäläinen Jarkko I; Poutiainen Sami; Leskinen Harri; Vepsäläinen Jouko; Christiaans Johannes A M; Forsberg Markus M; Männistö Pekka T; Wallén Erik A A
2(S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors.
Bioorganic & medicinal chemistry 2007;15(5):2024-31.
2007: Jalkanen Aaro J; Puttonen Katja A; Venäläinen Jarkko I; Sinervä Veijo; Mannila Anne; Ruotsalainen Sirja; Jarho Elina M; Wallén Erik A A; Männistö Pekka T
Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats.
Basic & clinical pharmacology & toxicology 2007;100(2):132-8.
2007: García-Horsman J A; Männistö P T; Venäläinen J I
On the role of prolyl oligopeptidase in health and disease.
Neuropeptides 2007;41(1):1-24.
2007: Mönkkönen Kati S; Hakumäki Juhana M; Hirst Robert A; Miettinen Riitta A; O'Callaghan Christopher; Männistö Pekka T; Laitinen Jarmo T
Intracerebroventricular antisense knockdown of G alpha i2 results in ciliary stasis and ventricular dilatation in the rat.
BMC neuroscience 2007;8():26.
2007: Grice Dorothy E; Reenilä Ilkka; Männistö Pekka T; Brooks Andrew I; Smith George G; Golden Greg T; Buxbaum Joseph D; Berrettini Wade H
Transcriptional profiling of C57 and DBA strains of mice in the absence and presence of morphine.
BMC genomics 2007;8():76.
2006: Puttonen Katja A; Lehtonen Sárka; Raasmaja Atso; Männistö Pekka T
A prolyl oligopeptidase inhibitor, Z-Pro-Prolinal, inhibits glyceraldehyde-3-phosphate dehydrogenase translocation and production of reactive oxygen species in CV1-P cells exposed to 6-hydroxydopamine.
Toxicology in vitro : an international journal published in association with BIBRA 2006;20(8):1446-54.
2006: Jarho Elina M; Venäläinen Jarkko I; Juntunen Juha; Yli-Kokko A Leena; Vepsäläinen Jouko; Christiaans Johannes A M; Forsberg Markus M; Järvinen Tomi; Männistö Pekka T; Wallén Erik A A
An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(21):5590-3.
2006: Venäläinen Jarkko I; Garcia-Horsman J Arturo; Forsberg Markus M; Jalkanen Aaro; Wallén Erik A A; Jarho Elina M; Christiaans Johannes A M; Gynther Jukka; Männistö Pekka T
Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.
Biochemical pharmacology 2006;71(5):683-92.
2005: Venäläinen Jarkko I; Wallén Erik A A; Poso Antti; García-Horsman J Arturo; Männistö Pekka T
Synthesis and characterization of the novel fluorescent prolyl oligopeptidase inhibitor 4-fluoresceinthiocarbamoyl-6-aminocaproyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine.
Journal of medicinal chemistry 2005;48(23):7093-5.
2005: Yavich Leonid; Oksman Mari; Tanila Heikki; Kerokoski Petri; Hiltunen Mikko; van Groen Thomas; Puoliväli Jukka; Männistö Pekka T; García-Horsman Arturo; MacDonald Ewen; Beyreuther Konrad; Hartmann Tobias; Jäkälä Pekka
Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.
Neurobiology of disease 2005;20(2):303-13.
2005: Jarho Elina M; Wallén Erik A A; Christiaans Johannes A M; Forsberg Markus M; Venäläinen Jarkko I; Männistö Pekka T; Gynther Jukka; Poso Antti
Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.
Journal of medicinal chemistry 2005;48(15):4772-82.
2005: Forsberg Markus M; Huotari Marko; Savolainen Jouko; Männistö Pekka T
The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;24(5):503-11.
2005: Manáková Sárka; Singh Amanpreet; Kääriäinen Tiina; Taari Heli; Kulkarni Shrinivas K; Männistö Pekka T
Failure of FK506 (tacrolimus) to alleviate apomorphine-induced circling in rat Parkinson model in spite of some cytoprotective effects in SH-SY5Y dopaminergic cells.
Brain research 2005;1038(1):83-91.
2005: Seeman Philip; Weinshenker David; Quirion Remi; Srivastava Lalit K; Bhardwaj Sanjeev K; Grandy David K; Premont Richard T; Sotnikova Tatyana D; Boksa Patricia; El-Ghundi Mufida; O'dowd Brian F; George Susan R; Perreault Melissa L; Männistö Pekka T; Robinson Siobhan; Palmiter Richard D; Tallerico Teresa
Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3513-8.
2004: Manáková Sárka; Puttonen Katja A; Raasmaja Atso; Männistö Pekka T
The roles of dopamine transporter and Bcl-2 protein in the protection of CV1-P cells from 6-OHDA-induced toxicity.
Toxicology letters 2004;154(1-2):117-23.
2004: Jarho Elina M; Venäläinen Jarkko I; Huuskonen Juhani; Christiaans Johannes A M; Garcia-Horsman J Arturo; Forsberg Markus M; Järvinen Tomi; Gynther Jukka; Männistö Pekka T; Wallén Erik A A
A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors.
Journal of medicinal chemistry 2004;47(23):5605-7.
2004: Lampela Pasi; Soininen Päivi; Puttonen Katja A; Ruponen Marika; Urtti Arto; Männistö Pekka T; Raasmaja Atso
Effect of cell-surface glycosaminoglycans on cationic carrier combined with low-MW PEI-mediated gene transfection.
International journal of pharmaceutics 2004;284(1-2):43-52.
2004: Forsberg Markus M; Juvonen Risto O; Helisalmi Petra; Leppänen Jukka; Gogos Joseph A; Karayiorgou Maria; Männistö Pekka T
Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(4):279-89.
2004: Venäläinen Jarkko I; Juvonen Risto O; Garcia-Horsman J Arturo; Wallén Erik A A; Christiaans Johannes A M; Jarho Elina M; Gynther Jukka; Männistö Pekka T
Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site.
The Biochemical journal 2004;382(Pt 3):1003-8.
2004: Venäläinen Jarkko I; Juvonen Risto O; Männistö Pekka T
Evolutionary relationships of the prolyl oligopeptidase family enzymes.
European journal of biochemistry / FEBS 2004;271(13):2705-15.
2004: Lampela Pasi; Soininen Päivi; Urtti Arto; Männistö Pekka T; Raasmaja Atso
Synergism in gene delivery by small PEIs and three different nonviral vectors.
International journal of pharmaceutics 2004;270(1-2):175-84.
2004: Huotari Marko; García-Horsman J Arturo; Karayiorgou Maria; Gogos Joseph A; Männistö Pekka T
D-amphetamine responses in catechol-O-methyltransferase (COMT) disrupted mice.
Psychopharmacology 2004;172(1):1-10.
2003: Helkamaa Teemu; Männistö Pekka T; Rauhala Pekka; Cheng Zhong Jian; Finckenberg Piet; Huotari Marko; Gogos Joseph A; Karayiorgou Maria; Mervaala Eero M
Resistance to salt-induced hypertension in catechol-O-methyltransferase-gene-disrupted mice.
Journal of hypertension 2003;21(12):2365-74.
2003: Helkamaa Teemu; Finckenberg Piet; Louhelainen Marjut; Merasto Saara; Rauhala Pekka; Lapatto Risto; Cheng Zhong Jian; Reenilä Ilkka; Männistö Pekka; Müller Dominik N; Luft Friedrich C; Mervaala Eero M
Entacapone protects from angiotensin II-induced inflammation and renal injury.
Journal of hypertension 2003;21(12):2353-63.
2003: Lampela Pasi; Huotari Marko; Harjula Anu; Oinonen Lasse; Ustav Mart; Ylä-Herttuala Seppo; Männistö Pekka T; Raasmaja Atso
Production of functional recombinant tyrosine hydroxylase by the BPV-1 expression plasmids in the cell cultures.
Plasmid 2003;50(3):230-5.
2003: Wallén Erik A A; Christiaans Johannes A M; Jarho Elina M; Forsberg Markus M; Venäläinen Jarkko I; Männistö Pekka T; Gynther Jukka
New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides.
Journal of medicinal chemistry 2003;46(21):4543-51.
2003: Lecklin Anne; Lundell Ingrid; Salmela Suvi; Männistö Pekka T; Beck-Sickinger Annette G; Larhammar Dan
Agonists for neuropeptide Y receptors Y1 and Y5 stimulate different phases of feeding in guinea pigs.
British journal of pharmacology 2003;139(8):1433-40.
2003: Wallén Erik A A; Christiaans Johannes A M; Saarinen Taija J; Jarho Elina M; Forsberg Markus M; Venäläinen Jarkko I; Männistö Pekka T; Gynther Jukka
Conformationally rigid N-acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors.
Bioorganic & medicinal chemistry 2003;11(17):3611-9.
2003: Lozeva Violina; Tarhanen Juhani; Attila Martti; Männistö Pekka T; Tuomisto Leena
Brain histamine and histamine H3 receptors following repeated L-histidine administration in rats.
Life sciences 2003;73(12):1491-503.
2003: Haasio Kristiina; Huotari Marko; Nissinen Erkki; Männistö Pekka T
Tissue histopathology, clinical chemistry and behaviour of adult Comt-gene-disrupted mice.
Journal of applied toxicology : JAT 2003;23(4):213-9.
2003: Puttonen K A; Manáková S; Raasmaja A; Männistö P T
Increased p53 levels without caspase-3 activity and change of cell viability in 6-hydroxydopamine-treated CV1-P cells.
Cell biology and toxicology 2003;19(3):177-87.
2003: Mañáková Sárka; Puttonen Katja A; Raasmaja Atso; Männistö Pekka T
Ara-C induces apoptosis in monkey fibroblast cells.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(3):367-73.
2003: Yavich Leonid; Sirviö Jouni; Haapalinna Antti; Ylinen Aarne; Männistö Pekka T
Atipamezole, an alpha2-adrenoceptor antagonist, augments the effects of L-DOPA on evoked dopamine release in rat striatum.
European journal of pharmacology 2003;462(1-3):83-9.
2003: Lampela Pasi; Elomaa Matti; Ruponen Marika; Urtti Arto; Männistö Pekka T; Raasmaja Atso
Different synergistic roles of small polyethylenimine and Dosper in gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2003;88(1):173-83.
2003: Forsberg Markus; Lehtonen Marko; Heikkinen Minna; Savolainen Jouko; Järvinen Tomi; Männistö Pekka T
Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat.
The Journal of pharmacology and experimental therapeutics 2003;304(2):498-506.
2002: Huotari Marko; Santha Miklos; Lucas Louis R; Karayiorgou Maria; Gogos Joseph A; Männistö Pekka T
Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice.
The Journal of pharmacology and experimental therapeutics 2002;303(3):1309-16.
2002: Wallén Erik A A; Christiaans Johannes A M; Forsberg Markus M; Venäläinen Jarkko I; Männistö Pekka T; Gynther Jukka
Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors.
Journal of medicinal chemistry 2002;45(20):4581-4.
2002: Odlind Cecilia; Reenilä Ilkka; Männistö Pekka T; Juvonen Risto; Uhlén Staffan; Gogos Joseph A; Karayiorgou Maria; Hansell Peter
Reduced natriuretic response to acute sodium loading in COMT gene deleted mice.
BMC physiology 2002;2():14.
2002: Venäläinen Jarkko I; Juvonen Risto O; Forsberg Markus M; Garcia-Horsman Arturo; Poso Antti; Wallen Erik A A; Gynther Jukka; Männistö Pekka T
Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819.
Biochemical pharmacology 2002;64(3):463-71.
2002: Wallén Erik A A; Christiaans Johannes A M; Saario Susanna M; Forsberg Markus M; Venäläinen Jarkko I; Paso Hanna M; Männistö Pekka T; Gynther Jukka
4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors.
Bioorganic & medicinal chemistry 2002;10(7):2199-206.
2002: Forsberg Markus; Savolainen Jouko; Järvinen Tomi; Leppänen Jukka; Gynther Jukka; Männistö Pekka T
Pharmacodynamic response of entacapone in rats after administration of entacapone formulations and prodrugs with varying bioavailabilities.
Pharmacology & toxicology 2002;90(6):327-32.
2002: Lozeva V; Tuominen R K; Männistö P T; Tuomisto L
Effect of repeated L-histidine administration on plasma prolactin and growth hormone levels in rats.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51 Suppl 1():S44-5.
2002: Lecklin Anne; Lundell Ingrid; Paananen Leena; Wikberg Jarl E S; Männistö Pekka T; Larhammar Dan
Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig.
British journal of pharmacology 2002;135(8):2029-37.
2002: Lampela Pasi; Räisänen Johanna; Männistö Pekka T; Ylä-Herttuala Seppo; Raasmaja Atso
The use of low-molecular-weight PEIs as gene carriers in the monkey fibroblastoma and rabbit smooth muscle cell cultures.
The journal of gene medicine 2002;4(2):205-14.
2002: Huotari Marko; Gogos Joseph A; Karayiorgou Maria; Koponen Olli; Forsberg Markus; Raasmaja Atso; Hyttinen Juha; Männistö Pekka T
Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice.
The European journal of neuroscience 2002;15(2):246-56.
2001: Lampela P; Ustav E; Ustav M; Niskanen M; Männistö P T; Raasmaja A
Efficient transfection of novel bovine papillomavirus 1 expression plasmids.
Plasmid 2001;46(3):163-9.
2001: Reenilä I; Männistö P T
Catecholamine metabolism in the brain by membrane-bound and soluble catechol-o-methyltransferase (COMT) estimated by enzyme kinetic values.
Medical hypotheses 2001;57(5):628-32.
2001: Leppänen J; Savolainen J; Nevalainen T; Forsberg M; Huuskonen J; Taipale H; Gynther J; Männistö P T; Järvinen T
Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs.
The Journal of pharmacy and pharmacology 2001;53(11):1489-98.
2001: Kõks S; Volke V; Veraksits A; Rünkorg K; Sillat T; Abramov U; Bourin M; Huotari M; Männistö P T; Matsui T; Vasar E
Cholecystokinin2 receptor-deficient mice display altered function of brain dopaminergic system.
Psychopharmacology 2001;158(2):198-204.
2001: Laitinen K S; van Groen T; Tanila H; Venäläinen J; Männistö P T; Alafuzoff I
Brain prolyl oligopeptidase activity is associated with neuronal damage rather than beta-amyloid accumulation.
Neuroreport 2001;12(15):3309-12.
2001: Keski-Hynnilä H; Raanaa K; Forsberg M; Männistö P; Taskinen J; Kostiainen R
Quantitation of entacapone glucuronide in rat plasma by on-line coupled restricted access media column and liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2001;759(2):227-36.
2001: Huotari M; Passlin M; Nordberg H L; Forsberg M; Kotisaari S; Tuomisto L; Shintani F; Tanaka K F; Reenilä I; Laitinen K; Männistö P T
Effect of intracerebral 6-nitronoradrenaline, an endogenous catechol-O-methyltransferase (COMT) inhibitor, on striatal dopamine metabolism in anaesthetised rats.
Journal of neuroscience methods 2001;109(1):47-52.
2001: Odlind C; Reenilä I; Männistö P T; Ekblom J; Hansell P
The role of dopamine-metabolizing enzymes in the regulation of renal sodium excretion in the rat.
Pflügers Archiv : European journal of physiology 2001;442(4):505-10.
2000: Anichtchik O V; Huotari M; Peitsaro N; Haycock J W; Männistö P T; Panula P
Modulation of histamine H3 receptors in the brain of 6-hydroxydopamine-lesioned rats.
The European journal of neuroscience 2000;12(11):3823-32.
2000: Lozeva V; Plumed C; Männistö P T; Tuomisto L
Regional distribution of histamine H3 receptor binding sites in rat brain following L-histidine loading--an autoradiography study.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2000;49 Suppl 1():S47-8.
2000: Lecklin A; Hermonen P; Tarhanen J; Männistö P T
An acute i.c.v. infusion of leptin has no effect on hypothalamic histamine and tele-methylhistamine contents in Wistar rats.
European journal of pharmacology 2000;395(2):113-9.
2000: Kõks S; Männistö P T; Bourin M; Shlik J; Vasar V; Vasar E
Cholecystokinin-induced anxiety in rats: relevance of pre-experimental stress and seasonal variations.
Journal of psychiatry & neuroscience : JPN 2000;25(1):33-42.
2000: Koskinen T; Ruotsalainen S; Puumala T; Lappalainen R; Koivisto E; Männistö P T; Sirviö J
Activation of 5-HT2A receptors impairs response control of rats in a five-choice serial reaction time task.
Neuropharmacology 2000;39(3):471-81.
1999: Võikar V; Soosaar A; Volke V; Kõks S; Bourin M; Männistö P T; Vasar E
Apomorphine-induced behavioural sensitization in rats: individual differences, role of dopamine and NMDA receptors.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1999;9(6):507-14.
1999: Männistö P T; Kaakkola S
Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors.
Pharmacological reviews 1999;51(4):593-628.
1999: Huotari M; Gainetdinov R; Männistö P T
Microdialysis studies on the action of tolcapone on pharmacologically-elevated extracellular dopamine levels in conscious rats.
Pharmacology & toxicology 1999;85(5):233-8.
1999: Tupala E; Haapalinna A; Viitamaa T; Männistö P T; Saano V
Effects of repeated low dose administration and withdrawal of haloperidol on sexual behaviour of male rats.
Pharmacology & toxicology 1999;84(6):292-5.
1999: Lozeva V; Männistö P T; Tuomisto L
Histamine H3 receptor binding sites in rat cortex following L-histidine loading.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1999;48 Suppl 1():S59-60.
1999: Kovalainen J T; Christiaans J A; Kotisaari S; Laitinen J T; Männistö P T; Tuomisto L; Gynther J
Synthesis and in vitro pharmacology of a series of new chiral histamine H3-receptor ligands: 2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives.
Journal of medicinal chemistry 1999;42(7):1193-202.
1999: Lozeva V; Anttila E; Tuominen R K; Hippeläinen M; Männistö P T; Tuomisto L
Hypothalamic histamine, growth rate, plasma prolactin and growth hormone levels in rats with long-term portacaval anastomosis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1999;48(2):81-5.
1998: Suomalainen M; Männistö P T
Lack of effect of leptin on the behaviour of mice predicting the level of anxiety and depression.
Pharmacology & toxicology 1998;83(3):139-42.
1998: Li Y H; Wirth T; Huotari M; Laitinen K; MacDonald E; Männistö P T
No change of brain extracellular catecholamine levels after acute catechol-O-methyltransferase inhibition: a microdialysis study in anaesthetized rats.
European journal of pharmacology 1998;356(2-3):127-37.
1998: Kõks S; Soosaar A; Võikar V; Volke V; Ustav M; Männistö P T; Bourin M; Vasar E
Opioid antagonist naloxone potentiates anxiogenic-like action of cholecystokinin agonists in elevated plus-maze.
Neuropeptides 1998;32(3):235-40.
1998: Volke V; Soosaar A; Kõks S; Vasar E; Männistö P T
L-Arginine abolishes the anxiolytic-like effect of diazepam in the elevated plus-maze test in rats.
European journal of pharmacology 1998;351(3):287-90.
1998: Hansell P; Odlind C; Männistö P T
Different renal effects of two inhibitors of catechol-O-methylation in the rat: entacapone and CGP 28014.
Acta physiologica Scandinavica 1998;162(4):489-94.
1998: Castrén E; Männistö P T; Tiihonen J
[What's new in neuropharmacology?]
Duodecim; lääketieteellinen aikakauskirja 1998;114(10):993-1001.
1998: Männistö P T
Catechol O-methyltransferase: characterization of the protein, its gene, and the preclinical pharmacology of COMT inhibitors.
Advances in pharmacology (San Diego, Calif.) 1998;42():324-8.
1997: Kõks S; Vasar E; Soosaar A; Lang A; Volke V; Võikar V; Bourin M; Männistö P T
Relation of exploratory behavior of rats in elevated plus-maze to brain receptor binding properties and serum growth hormone levels.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1997;7(4):289-94.
1997: Reenilä I; Tuomainen P; Soinila S; Männistö P T
Increase of catechol-O-methyltransferase activity in rat brain microglia after intrastriatal infusion of fluorocitrate, a glial toxin.
Neuroscience letters 1997;230(3):155-8.
1997: Volke V; Soosaar A; Kõks S; Bourin M; Männistö P T; Vasar E
7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety.
Psychopharmacology 1997;131(4):399-405.
1997: Khromova I; Voronina T; Kraineva V A; Zolotov N; Männistö P T
Effects of selective catechol-O-methyltransferase inhibitors on single-trial passive avoidance retention in male rats.
Behavioural brain research 1997;86(1):49-57.
1997: Tuomainen P; Männistö P T
Optimization of the hydrolysis of conjugated L-DOPA, dopamine and dihydroxyphenylacetic acid in human urine for assay by high-performance liquid chromatography with electrochemical detection.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1997;35(3):229-35.
1997: Kask A; Harro J; Tuomaine P; Rägo L; Männistö P T
Overflow of noradrenaline and dopamine in frontal cortex after [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine] (DSP-4) treatment: in vivo microdialysis study in anaesthetized rats.
Naunyn-Schmiedeberg's archives of pharmacology 1997;355(2):267-72.
1997: Liljequist R; Haapalinna A; Ahlander M; Li Y H; Männistö P T
Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats.
Behavioural brain research 1997;82(2):195-202.
1996: Aarnisalo A M; Vainio P J; Männistö P T; Vasar E; Tuominen R K
Evidence for cholecystokininA receptors in bovine adrenal chromaffin cells.
Neuroreport 1996;7(13):2167-70.
1996: Volke V; Soosaar A; Kõks S; Bourin M; Männistö P T; Vasar E
Nitric oxide mediates caerulein-induced suppression of locomotor activity.
Neuropeptides 1996;30(4):323-6.
1996: Tuomainen P; Törnwall M; Männistö P T
Minor effect of tolcapone, a catechol-O-methyltransferase inhibitor, on extracellular dopamine levels modified by amphetamine or pargyline: a microdialysis study in anaesthetized rats.
Pharmacology & toxicology 1996;78(6):392-6.
1996: Borisenko S A; Meng Q H; Rauhala P; Männistö P T
Neurochemical mediators of anxiety have inconsistent effects on hypothalamic self-stimulation in rats.
Pharmacology & toxicology 1996;78(5):354-60.
1996: Idänpään-Heikkilä J J; Rauhala P; Männistö P T
Neuroendocrine effects of dexmedetomidine: evidence of cross-tolerance between a mu-opioid agonist and an alpha 2-adrenoceptor agonist in growth hormone secretion of the male rat.
Pharmacology & toxicology 1996;78(3):136-42.
1996: Idänpään-Heikkilä J J; Rauhala P; Tuominen R K; Tuomainen P; Zolotov N; Männistö P T
Morphine withdrawal alters anterior pituitary hormone secretion, brain endopeptidase activity and brain monoamine metabolism in the rat.
Pharmacology & toxicology 1996;78(3):129-35.
1996: Tuomainen P; Reenilä I; Männistö P T
Validation of assay of catechol-O-methyltransferase activity in human erythrocytes.
Journal of pharmaceutical and biomedical analysis 1996;14(5):515-23.
1995: Reenilä I; Tuomainen P; Tilgmann C; Männistö P T
Opposite effect of ethanol on recombinant membrane-bound and soluble activities of catechol-O-methyltransferase.
Pharmacology & toxicology 1995;77(6):414-6.
1995: Rauhala P; Idänpään-Heikkilä J J; Tuominen R K; Männistö P T
Differential disappearance of tolerance to thermal, hormonal and locomotor effects of morphine in the male rat.
European journal of pharmacology 1995;285(1):69-77.
1995: Idänpään-Heikkilä J J; Rauhala P; Männistö P T
mu- and delta-opioid receptor antisense oligodeoxynucleotides antagonize morphine-induced growth hormone secretion in rats.
European journal of pharmacology 1995;284(1-2):227-30.
1995: Volke V; Kõks S; Vasar E; Bourin M; Bradwejn J; Männistö P T
Inhibition of nitric oxide synthase causes anxiolytic-like behaviour in an elevated plus-maze.
Neuroreport 1995;6(10):1413-6.
1995: Khromova I; Rauhala P; Zolotov N; Männistö P T
Tolcapone, an inhibitor of catechol O-methyltransferase, counteracts memory deficits caused by bilateral cholinotoxin lesions of the basal nuclei of Meynert.
Neuroreport 1995;6(8):1219-22.
1995: Rauhala P; Idänpään-Heikkilä J J; Lang A; Tuominen R K; Männistö P T
Cold exposure attenuates effects of secretagogues on serum prolactin and growth hormone levels in male rats.
The American journal of physiology 1995;268(4 Pt 1):E758-65.
1995: Lang A; Harro J; Soosaar A; Kõks S; Volke V; Oreland L; Bourin M; Vasar E; Bradwejn J; Männistö P T
Role of N-methyl-D-aspartic acid and cholecystokinin receptors in apomorphine-induced aggressive behaviour in rats.
Naunyn-Schmiedeberg's archives of pharmacology 1995;351(4):363-70.
1995: Ahtila S; Kaakkola S; Gordin A; Korpela K; Heinävaara S; Karlsson M; Wikberg T; Tuomainen P; Männistö P T
Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers.
Clinical neuropharmacology 1995;18(1):46-57.
1995: Männistö P T; Lang A; Rauhala P; Vasar E
Beneficial effects of co-administration of catechol-O-methyltransferase inhibitors and L-dihydroxyphenylalanine in rat models of depression.
European journal of pharmacology 1995;274(1-3):229-33.
1995: Peuranen E; Vasar E; Koks S; Volke V; Lang A; Rauhala P; Männistö P T
Further studies on the role of cholecystokinin-A and B receptors in secretion of anterior pituitary hormones in male rats.
Neuropeptides 1995;28(1):1-11.
1995: Reenilä I; Tuomainen P; Männistö P T
Improved assay of reaction products to quantitate catechol-O-methyltransferase activity by high-performance liquid chromatography with electrochemical detection.
Journal of chromatography. B, Biomedical applications 1995;663(1):137-42.
1994: Kaakkola S; Gordin A; Männistö P T
General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase.
General pharmacology 1994;25(5):813-24.
1994: Männistö P T; Tuomainen P; Kutepova O; Borisenko S A; Zolotov N; Voronina T
Effects of bilateral cholinotoxin infusions on the behavior and brain biochemistry of the rats.
Pharmacology, biochemistry, and behavior 1994;49(1):33-40.
1994: Rauhala P; Idänpään-Heikkilä J J; Tuominen R K; Männistö P T
N-nitro-L-arginine attenuates development of tolerance to antinociceptive but not to hormonal effects of morphine.
European journal of pharmacology 1994;259(1):57-64.
1994: Männistö P T; Lang A; Harro J; Peuranen E; Bradwejn J; Vasar E
Opposite effects mediated by CCKA and CCKB receptors in behavioural and hormonal studies in rats.
Naunyn-Schmiedeberg's archives of pharmacology 1994;349(5):478-84.
1994: Törnwall M; Kaakkola S; Tuomainen P; Kask A; Männistö P T
Comparison of two new inhibitors of catechol O-methylation on striatal dopamine metabolism: a microdialysis study in rats.
British journal of pharmacology 1994;112(1):13-8.
1994: Männistö P T; Borisenko S A; Rauhala P; Tuomainen P; Tuominen R K
Variation in tolerance to the antinociceptive, hormonal and thermal effects of morphine after a 5-day pre-treatment of male rats with increasing doses of morphine.
Naunyn-Schmiedeberg's archives of pharmacology 1994;349(2):161-9.
1994: Vasar E; Lang A; Harro J; Kõks S; Volke V; Sihver S; Bourin M; Bradwejn J; Männistö P T
Subdiaphragmatic vagotomy does not prevent the anti-exploratory effect of caerulein in the elevated plus-maze.
Neuropeptides 1994;26(1):39-45.
1994: Viluksela M; Debets F M; van der Hoeven J C; Männistö P T
Dithranol (anthralin) and 10-butyryl dithranol (butantrone) do not morphologically transform cultured C3H 10T1/2 C18 mouse embryo fibroblasts.
Acta dermato-venereologica 1994;74(1):54-6.
1993: Törnwall M; Männistö P T
Effects of three types of catechol O-methylation inhibitors on L-3,4-dihydroxyphenylalanine-induced circling behaviour in rats.
European journal of pharmacology 1993;250(1):77-84.
1993: Törnwall M; Tuomainen P; Männistö P T
Modulation of rat brain endogenous dopamine metabolism by new inhibitors of catechol O-methyltransferase.
European journal of pharmacology 1993;239(1-3):39-45.
1993: Vasar E; Peuranen E; Harro J; Lang A; Oreland L; Männistö P T
Social isolation of rats increases the density of cholecystokinin receptors in the frontal cortex and abolishes the anti-exploratory effect of caerulein.
Naunyn-Schmiedeberg's archives of pharmacology 1993;348(1):96-101.
1993: Laakso M L; Porkka-Heiskanen T; Leinonen L; Joutsiniemi S L; Männistö P T
Hormonal and locomotor activity rhythms in rats under 90-min dark-pulse conditions.
The American journal of physiology 1993;264(6 Pt 2):R1058-64.
1993: Kaakkola S; Tuomainen P; Männistö P T; Palo J
Biogenic amine metabolites in the CSF of patients with late onset and alcoholic ataxias.
Acta neurologica Scandinavica 1993;87(4):309-11.
1993: Mäkinen M; Ahtee L; Rosenqvist K; Tuominen R K; Männistö P
Effects of intraventricular taurine, homotaurine and GABA on serum prolactin and thyrotropin levels in female and in male rats.
Journal of neural transmission. General section 1993;94(3):155-63.
1993: Vasar E; Peuranen E; Oöpik T; Harro J; Männistö P T
Ondansetron, an antagonist of 5-HT3 receptors, antagonizes the anti-exploratory effect of caerulein, an agonist of CCK receptors, in the elevated plus-maze.
Psychopharmacology 1993;110(1-2):213-8.
1992: Männistö P T; Peuranen E; Harro J; Vasar E
Possible role of cholecystokinin-A receptors in regulation of thyrotropin (TSH) secretion in male rats.
Neuropeptides 1992;23(4):251-8.
1992: Törnwall M; Tuomainen P; Männistö P T
Neurochemical and psychomotor interactions of new selective COMT inhibitors with clorgyline and nomifensine in levodopa-treated rats and mice.
Archives internationales de pharmacodynamie et de thérapie 1992;320():5-20.
1992: Männistö P T; Törnwall M; Tuomainen P; Borisenko S A; Tuominen R K
Effect of nitecapone and clorgyline, given intracerebro-ventricularly on L-dopa metabolism in the rat brain.
Neuroreport 1992;3(7):641-4.
1992: Männistö P T; Laakso M L; Järvinen A; Rägo L
Effects of central and peripheral type benzodiazepine ligands on growth hormone and gonadotropin secretion in male rats.
Pharmacology & toxicology 1992;71(1):75-80.
1992: Vainio P J; Viluksela M; Männistö P T
Absorption of various erythromycin esters and salts in mice after intragastric intubation.
Methods and findings in experimental and clinical pharmacology 1992;14(5):367-72.
1992: Männistö P T; Tuomainen P; Tuominen R K
Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat.
British journal of pharmacology 1992;105(3):569-74.
1992: Järvinen A; Rägo L; Männistö P T
Effects of central and peripheral type benzodiazepine ligands on thyrotropin and prolactin secretion.
Neuropeptides 1992;21(3):183-91.
1992: Kaakkola S; Tuomainen P; Wurtman R J; Männistö P T
Effects of systemic carbidopa on dopamine synthesis in rat hypothalamus and striatum.
Journal of neural transmission. Parkinson's disease and dementia section 1992;4(2):143-54.
1992: Männistö P T; Ulmanen I; Lundström K; Taskinen J; Tenhunen J; Tilgmann C; Kaakkola S
Characteristics of catechol O-methyl-transferase (COMT) and properties of selective COMT inhibitors.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 1992;39():291-350.
1991: Männistö P T; Tuomainen P
Effect of high single doses of levodopa and carbidopa on brain dopamine and its metabolites: modulation by selective inhibitors of monoamine oxidase and/or catechol-O-methyltransferase in the male rat.
Naunyn-Schmiedeberg's archives of pharmacology 1991;344(4):412-8.
1991: Törnwall M; Männistö P T
Acute toxicity of three new selective COMT inhibitors in mice with special emphasis on interactions with drugs increasing catecholaminergic neurotransmission.
Pharmacology & toxicology 1991;69(1):64-70.
1991: Järvinen A; Paakkari I; Männistö P T
Central and peripheral type benzodiazepine ligands displace [3H][3-ME-HIS2]TRH from its binding sites in the brain and the anterior pituitary and antagonize the effect of TRH in the rat duodenum.
Neuropeptides 1991;19(3):147-55.
1990: Toivonent M; Tuomainen P; Rauhala P; Männistö P T
Effects of cysteamine pretreatment and hypothalamic periventricular nucleus lesion on the cold-stimulated thyrotropin responses to intracerebroventricular 5-hydroxytryptamine in male rats.
Journal of neuroendocrinology 1990;2(4):485-92.
1990: Laakso M L; Porkka-Heiskanen T; Stenberg D; Johansson G; Männistö P T
Lighting conditions affect serum and pituitary TSH in male rats.
The American journal of physiology 1990;259(2 Pt 1):E162-9.
1990: Viluksela M; Haasio K; Männistö P T
Studies on the contact sensitizing activity of dithranol (anthralin) and 10-butyryl dithranol (butantrone).
Contact dermatitis 1990;23(2):103-10.
1990: Männistö P T; Kaakkola S
Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease.
Pharmacology & toxicology 1990;66(5):317-23.
1990: Toivonen M; Männistö P T
Complex actions of serotonergic agonists on cold-stimulated TSH secretion in male rats.
European journal of pharmacology 1990;180(1):91-102.
1990: Toivonen M; Tuomainen P; Männistö P T
Effects of hypothalamic paraventricular nucleus lesion on the cold-stimulated TSH responses to 5-HT in male rats.
Acta physiologica Scandinavica 1990;139(1):233-40.
1990: Toivonen M; Rauhala P; Männistö P T
Site-dependent action of intracerebroventricular 5-hydroxytryptamine on the cold-stimulated thyrotropin secretion in male rats.
Neuroendocrinology 1990;51(1):45-50.
1990: Männistö P T; Tuomainen P; Toivonen M; Törnwall M; Kaakkola S
Effect of acute levodopa on brain catecholamines after selective MAO and COMT inhibition in male rats.
Journal of neural transmission. Parkinson's disease and dementia section 1990;2(1):31-43.
1989: Pitkänen A; Beal M F; Sirviö J; Swartz K J; Männistö P T; Riekkinen P J
Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats.
Neuropeptides 1989;14(3):197-207.
1989: Männistö P T; Hanhijärvi H; Havas A; Vuorela A; Komulainen H; Rauramaa V
Efficacy of erythromycin acistrate (2'-acetyl erythromycin stearate) and erythromycin stearate in experimental infections in mice.
The Journal of pharmacology and experimental therapeutics 1989;250(3):1028-33.
1989: Panula-Lehto E; Ahtee L; Tuominen R K; Männistö P T
Comparison of the effects of intraventricular taurine, GABA and homotaurine on serum prolactin levels in male rats.
Pharmacology & toxicology 1989;65(2):152-6.
1989: Kaukoranta-Tolvanen S S; Renkonen O V; Gordin A; Tamm L; Männistö P T
Effect of erythromycin acistrate and erythromycin stearate on human colonic microflora.
Scandinavian journal of infectious diseases 1989;21(6):717-20.
1988: Männistö P T; Suomela A; Rauhala P; Tuominen R K; Suolinna T
Cholinergic regulation of thyrotropin secretion in male rats.
European journal of pharmacology 1988;157(2-3):117-24.
1988: Lindén I B; Nissinen E; Etemadzadeh E; Kaakkola S; Männistö P; Pohto P
Favorable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parkinson's disease.
The Journal of pharmacology and experimental therapeutics 1988;247(1):289-93.
1988: Rauhala P; Männistö P T; Tuominen R K
Effect of chronic morphine treatment on thyrotropin and prolactin levels and acute hormone responses in the rat.
The Journal of pharmacology and experimental therapeutics 1988;246(2):649-54.
1988: Männistö P T; Tuominen R K
Further studies of serotonergic activity in the regulation of the cold stimulated thyrotropin secretion in male rats.
Pharmacology & toxicology 1988;63(2):65-9.
1988: Korkeala H; Männistö P T
Time course of the antibacterial activity of erythromycin stearate and erythromycin acistrate against two Staphylococcus aureus strains in vitro.
The Journal of antimicrobial chemotherapy 1988;22(2):127-33.
1988: Nissinen E; Lindén I B; Schultz E; Kaakkola S; Männistö P T; Pohto P
Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat.
European journal of pharmacology 1988;153(2-3):263-9.
1988: Gordin A; Männistö P T; Antikainen R; Savolainen S; Ylikoski J; Kokkonen P; Rauramaa V
Concentrations of erythromycin, 2'-acetyl erythromycin, and their anhydro forms in plasma and tonsillar tissue after repeated dosage of erythromycin stearate and erythromycin acistrate.
Antimicrobial agents and chemotherapy 1988;32(7):1019-24.
1988: Savolainen S; Männistö P T; Gordin A; Antikainen R; Haataja H; Tuominen R K; Ylikoski J
Tonsillar penetration of erythromycin and its 2'-acetyl ester in patients with chronic tonsillitis.
The Journal of antimicrobial chemotherapy 1988;21 Suppl D():73-84.
1988: Tuominen R K; Männistö P T; Solkinen A; Vuorela A; Pohto P; Haataja H
Antibiotic concentration in suction skin blister fluid and saliva after repeated dosage of erythromycin acistrate and erythromycin base.
The Journal of antimicrobial chemotherapy 1988;21 Suppl D():57-65.
1988: Tuominen R K; Männistö P T; Pohto P; Solkinen A; Vuorela A
Absorption of erythromycin acistrate and erythromycin base in the fasting and non-fasting state.
The Journal of antimicrobial chemotherapy 1988;21 Suppl D():45-55.
1988: Männistö P T; Taskinen J; Ottoila P; Solkinen A; Vuorela A; Nykänen S
Fate of single oral doses of erythromycin acistrate, erythromycin stearate and pelleted erythromycin base analysed by mass-spectrometry in plasma of healthy human volunteers.
The Journal of antimicrobial chemotherapy 1988;21 Suppl D():33-43.
1988: Aho P; Männistö P T
Effects of two erythromycins, doxycycline and phenoxymethylpenicillin on human leucocyte chemotaxis in vitro.
The Journal of antimicrobial chemotherapy 1988;21 Suppl D():29-32.
1988: Vuorela A; Mäntylä R; Männistö P T
Tissue distribution of the novel antitussive compound vadocaine hydrochloride in white female mice studied by whole-body autoradiography.
Arzneimittel-Forschung 1988;38(4A):628-30.
1988: Mäntylä R; Männistö P T; Vuorela A; Nissinen E
Preliminary pharmacokinetics of the new antitussive compound vadocaine hydrochloride in animals.
Arzneimittel-Forschung 1988;38(4A):624-7.
1988: Etemadzadeh E; Ahtee L; Männistö P T
Comparative studies on the dependence liability of morphine hydrochloride, codeine phosphate and two novel antitussive compounds vadocaine hydrochloride and N-(2',4'-dimethyl-6'-methoxyphenyl)-4-(diethylamine) butanamide hydrochloride in mice.
Arzneimittel-Forschung 1988;38(4A):620-3.
1988: Männistö P T; Kaakkola S; Nissinen E; Linden I B; Pohto P
Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferase.
Life sciences 1988;43(18):1465-71.
1988: Rauhala P; Tuominen R K; Männistö P T
Opiate receptor subtypes in the regulation of thyrotropin and prolactin secretion in the rat.
Hormone research 1988;29(5-6):218-22.
1987: Männistö P T; Toivonen M; Tuominen R
Time relationships and reversal by two indoleamines of the pinealectomy-inhibited thyrotropin secretion in male rats.
Medical biology 1987;65(5-6):267-72.
1987: Männistö P T
Aminergic regulation of neuroendocrinological functions: theoretical background and some clinical examples.
Medical biology 1987;65(2-3):121-6.
1986: Hanhijärvi H; Voipio H M; Huuskonen H; Männistö P; Nevalainen T
Experimental compound OR-K-242-HCl an anilide derivative slows conduction velocity of the heart in the conscious beagle dog.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1986;9():213-6.
1985: Viitanen J; Haataja H; Männistö P T
Concentrations of metronidazole and tinidazole in male genital tissues.
Antimicrobial agents and chemotherapy 1985;28(6):812-4.
1985: Kaakkola S; Männistö P T; Nissinen E; Vuorela A; Mäntylä R
The effect of an increased ratio of carbidopa to levodopa on the pharmacokinetics of levodopa.
Acta neurologica Scandinavica 1985;72(4):385-91.
1985: Hanhijärvi H; Nevalainen T; Männistö P
A six month dermal irritation test with anthralins in the Göttingen miniature swine.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1985;8():463-8.
1984: Klinge E; Männistö P T; Mäntylä R; Mattila J; Hänninen U
Single- and multiple-dose pharmacokinetics of pipemidic acid in normal human volunteers.
Antimicrobial agents and chemotherapy 1984;26(1):69-73.
1984: Männistö P; Karhunen M; Mattila J; Koskela O; Suikkari A M; Heinonen P; Tuimala R; Haataja H
Concentrations of metronidazole and tinidazole in female reproductive organs after a single intravenous infusion and after repeated oral administration.
Infection 1984;12(3):197-201.
1984: Männistö P; Solkinen A; Mäntylä R; Gordin A; Salo H; Hänninen U; Niinistö L
Pharmacokinetics of pipemidic acid in healthy middle-aged volunteers and elderly patients with renal insufficiency.
Xenobiotica; the fate of foreign compounds in biological systems 1984;14(4):339-47.
1984: Männistö P; Havas A; Haasio K; Hanhijärvi H; Mustakallio K
Skin irritation by dithranol (anthralin) and its 10-acyl analogues in 3 animal models.
Contact dermatitis 1984;10(3):140-5.
1984: Viitanen J; Auvinen O; Tunturi T; Männistö P; Haataja H
Concentrations of metronidazole and tinidazole in abdominal tissues after a single intravenous infusion and repetitive oral administration.
Chemotherapy 1984;30(4):211-15.
1984: Mattila J; Mäntylä R; Vuorela A; Lamminsivu U; Männistö P
Pharmacokinetics of graded oral doses of sulindac in man.
Arzneimittel-Forschung 1984;34(2):226-9.
1983: Männistö P T; Karhunen M; Koskela O; Suikkari A M; Mattila J; Haataja H
Concentrations of tinidazole in breast milk.
Acta pharmacologica et toxicologica 1983;53(3):254-6.
1983: Mattila J; Männistö P T; Mäntylä R; Nykänen S; Lamminsivu U
Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route.
Antimicrobial agents and chemotherapy 1983;23(5):721-5.
1983: Mattila J; Nerdrum K; Rouhiainen H; Männistö P; Tuovinen E; Lamminsivu U
Penetration of metronidazole and tinidazole into the aqueous humor in man.
Chemotherapy 1983;29(3):188-91.
1982: Männistö P T; Mäntylä R; Mattila J; Nykänen S; Lamminsivu U
Comparison of pharmacokinetics of sulphadiazine and sulphamethoxazole after intravenous infusion.
The Journal of antimicrobial chemotherapy 1982;9(6):461-70.
1982: Männistö P T; Mäntylä R; Nykänen S; Lamminsivu U; Ottoila P
Impairing effect of food on ketoconazole absorption.
Antimicrobial agents and chemotherapy 1982;21(5):730-3.
1982: Klinge E; Männistö P; Mäntylä R; Lamminsivu U; Ottoila P
Pharmacokinetics of methenamine in healthy volunteers.
The Journal of antimicrobial chemotherapy 1982;9(3):209-16.

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