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Toshiaki Mano

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Yasushi Sakata; Yasuharu Takeda; Kazuhiro Yamamoto; Tomohito Ohtani; Toshiaki Mano
Left ventricular stiffening as therapeutic target for heart failure with preserved ejection fraction.
Daisuke Kamimura; Yutaka Komiyama; Issei Komuro; Toshiaki Mano; Toshio Matsuda; Takeshi Miwa; Tomohito Ohtani; Yosuke Omori; Yasushi Sakata; Hakuo Takahashi; Yasuharu Takeda; Shunsuke Tamaki; Yasumasa Tsukamoto; Satoshi Umemura; Akemichi Baba; Kazuharu Furutani; Masamichi Yoshika; Kazuhiro Yamamoto
Ca2+ entry mode of Na+/Ca2+ exchanger as a new therapeutic target for heart failure with preserved ejection fraction.
Yasuharu Takeda; Shunsuke Tamaki; Yasumasa Tsukamoto; Yoshihiro Aizawa; Issei Komuro; Toshiaki Mano; Tomohito Ohtani; Yosuke Omori; Yasushi Sakata; Kazuhiro Yamamoto
Diabetic retinopathy is associated with impaired left ventricular relaxation.

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All Publications

2013: Yasushi Sakata; Yasuharu Takeda; Kazuhiro Yamamoto; Tomohito Ohtani; Toshiaki Mano
Left ventricular stiffening as therapeutic target for heart failure with preserved ejection fraction.
Circulation journal : official journal of the Japanese Circulation Society 2013;77(4):886-92.
2012: Daisuke Kamimura; Yutaka Komiyama; Issei Komuro; Toshiaki Mano; Toshio Matsuda; Takeshi Miwa; Tomohito Ohtani; Yosuke Omori; Yasushi Sakata; Hakuo Takahashi; Yasuharu Takeda; Shunsuke Tamaki; Yasumasa Tsukamoto; Satoshi Umemura; Akemichi Baba; Kazuharu Furutani; Masamichi Yoshika; Kazuhiro Yamamoto
Ca2+ entry mode of Na+/Ca2+ exchanger as a new therapeutic target for heart failure with preserved ejection fraction.
European heart journal 2012;33(11):1408-16.
2011: Yasuharu Takeda; Shunsuke Tamaki; Yasumasa Tsukamoto; Yoshihiro Aizawa; Issei Komuro; Toshiaki Mano; Tomohito Ohtani; Yosuke Omori; Yasushi Sakata; Kazuhiro Yamamoto
Diabetic retinopathy is associated with impaired left ventricular relaxation.
Journal of cardiac failure 2011;17(7):556-60.
2011: Yasuharu Takeda; Yasushi Sakata; Toshiaki Mano; Tomohito Ohtani; Daisuke Kamimura; Shunsuke Tamaki; Yosuke Omori; Yasumasa Tsukamoto; Yoshihiro Aizawa; Issei Komuro; Kazuhiro Yamamoto
Competing risks of heart failure with preserved ejection fraction in diabetic patients.
European journal of heart failure 2011;13(6):664-9.
2011: Yoshihiro Aizawa; Yasushi Sakata; Toshiaki Mano; Yasuharu Takeda; Tomohito Ohtani; Shunsuke Tamaki; Yosuke Omori; Yasumasa Tsukamoto; Atsushi Hirayama; Issei Komuro; Kazuhiro Yamamoto
Transition from asymptomatic diastolic dysfunction to heart failure with preserved ejection fraction: roles of systolic function and ventricular distensibility.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(3):596-602.
2010: Shunsuke Tamaki; Yasushi Sakata; Toshiaki Mano; Tomohito Ohtani; Yasuharu Takeda; Daisuke Kamimura; Yousuke Omori; Kazuhiro Yamamoto
Long-term beta-blocker therapy improves diastolic function even without the therapeutic effect on systolic function in patients with reduced ejection fraction.
Journal of cardiology 2010;56(2):176-82.
2009: Tomohito Ohtani; Toshiaki Mano; Shungo Hikoso; Yasushi Sakata; Mayu Nishio; Yasuharu Takeda; Kinya Otsu; Takeshi Miwa; Tohru Masuyama; Masatsugu Hori; Kazuhiro Yamamoto
Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure.
Journal of hypertension 2009;27(5):1074-83.
2009: Kazuhiro Yamamoto; Yasushi Sakata; Tomohito Ohtani; Yasuharu Takeda; Toshiaki Mano
Heart failure with preserved ejection fraction.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(3):404-10.
2009: Yasuharu Takeda; Yasushi Sakata; Mitsuru Higashimori; Toshiaki Mano; Mayu Nishio; Tomohito Ohtani; Masatsugu Hori; Tohru Masuyama; Makoto Kaneko; Kazuhiro Yamamoto
Noninvasive assessment of wall distensibility with the evaluation of diastolic epicardial movement.
Journal of cardiac failure 2009;15(1):68-77.
2008: Mayu Nishio; Yasushi Sakata; Toshiaki Mano; Tomohito Ohtani; Yasuharu Takeda; Masatsugu Hori; Kazuhiro Yamamoto
Difference of clinical characteristics between hypertensive patients with and without diastolic heart failure: the roles of diastolic dysfunction and renal insufficiency.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(10):1865-72.
2008: Yasuharu Takeda; Yasushi Sakata; Toshiaki Mano; Mayu Nishio; Tomohito Ohtani; Masatsugu Hori; Tohru Masuyama; Kazuhiro Yamamoto
Noninvasive assessment of diastolic function in subjects with preserved left ventricular ejection fraction: usefulness of color kinetic imaging.
Journal of cardiac failure 2008;14(7):569-76.
2008: Mayu Nishio; Yasushi Sakata; Toshiaki Mano; Tomohito Ohtani; Yasuharu Takeda; Takeshi Miwa; Masatsugu Hori; Tohru Masuyama; Takashi Kondo; Kazuhiro Yamamoto
Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats.
European journal of heart failure 2008;10(5):446-53.
2007: Mayu Nishio; Yasushi Sakata; Toshiaki Mano; Junichi Yoshida; Tomohito Ohtani; Yasuharu Takeda; Takeshi Miwa; Tohru Masuyama; Kazuhiro Yamamoto; Masatsugu Hori
Therapeutic effects of angiotensin II type 1 receptor blocker at an advanced stage of hypertensive diastolic heart failure.
Journal of hypertension 2007;25(2):455-61.
2007: Tomohito Ohtani; Miho Ohta; Kazuhiro Yamamoto; Toshiaki Mano; Yasushi Sakata; Mayu Nishio; Yasuharu Takeda; Junichi Yoshida; Takeshi Miwa; Mitsuhiro Okamoto; Tohru Masuyama; Yasuki Nonaka; Masatsugu Hori
Elevated cardiac tissue level of aldosterone and mineralocorticoid receptor in diastolic heart failure: Beneficial effects of mineralocorticoid receptor blocker.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(2):R946-54.
2005: Nagahiro Nishikawa; Kazuhiro Yamamoto; Yasushi Sakata; Toshiaki Mano; Junichi Yoshida; Seiko Umekawa; Masatsugu Hori; Yuki Yasuhara; Teruyuki Sonoyama; Akimitsu Harada; Tohru Masuyama
Long-term effect of spironolactone on cardiac structure as assessed by analysis of ultrasonic radio-frequency signals in patients with ventricular hypertrophy.
Circulation journal : official journal of the Japanese Circulation Society 2005;69(11):1394-400.
2005: Junichi Yoshida; Kazuhiro Yamamoto; Toshiaki Mano; Yasushi Sakata; Mayu Nishio; Tomohito Ohtani; Masatsugu Hori; Takeshi Miwa; Tohru Masuyama
Different effects of long- and short-acting loop diuretics on survival rate in Dahl high-salt heart failure model rats.
Cardiovascular research 2005;68(1):118-27.
2005: Kazuhiro Yamamoto; Toshiaki Mano; Junichi Yoshida; Yasushi Sakata; Nagahiro Nishikawa; Mayu Nishio; Tomohito Ohtani; Masatsugu Hori; Takeshi Miwa; Tohru Masuyama
ACE inhibitor and angiotensin II type 1 receptor blocker differently regulate ventricular fibrosis in hypertensive diastolic heart failure.
Journal of hypertension 2005;23(2):393-400.
2004: Kazuhiro Yamamoto; Yoshito Takahashi; Toshiaki Mano; Yasushi Sakata; Nagahiro Nishikawa; Junichi Yoshida; Yuichi Oishi; Masatsugu Hori; Takeshi Miwa; Shintaro Inoue; Tohru Masuyama
N-methylethanolamine attenuates cardiac fibrosis and improves diastolic function: inhibition of phospholipase D as a possible mechanism.
European heart journal 2004;25(14):1221-9.
2004: Shoko Sugiyama; Hisao Hirota; Maki Yoshida; Yukiko Takemura; Yoshikazu Nakaoka; Yuichi Oshima; Kazuo Terai; Masahiro Izumi; Yasushi Fujio; Shinji Hasegawa; Toshiaki Mano; Yoshiaki Nakatsuchi; Masatsugu Hori; Keiko Yamauchi-Takihara; Ichiro Kawase
Novel insertional mutation in the bone morphogenetic protein receptor type II associated with sporadic primary pulmonary hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2004;68(6):592-4.
2004: Yasushi Sakata; Kazuhiro Yamamoto; Toshiaki Mano; Nagahiro Nishikawa; Junichi Yoshida; Masatsugu Hori; Takeshi Miwa; Tohru Masuyama
Activation of matrix metalloproteinases precedes left ventricular remodeling in hypertensive heart failure rats: its inhibition as a primary effect of Angiotensin-converting enzyme inhibitor.
Circulation 2004;109(17):2143-9.
2004: Junichi Yoshida; Kazuhiro Yamamoto; Toshiaki Mano; Yasushi Sakata; Nagahiro Nishikawa; Mayu Nishio; Tomohito Ohtani; Takeshi Miwa; Masatsugu Hori; Tohru Masuyama
AT1 receptor blocker added to ACE inhibitor provides benefits at advanced stage of hypertensive diastolic heart failure.
Hypertension 2004;43(3):686-91.
2004: Hitoshi Yamaguchi; Junichi Yoshida; Kazuhiro Yamamoto; Yasushi Sakata; Toshiaki Mano; Noriyuki Akehi; Masatsugu Hori; Young-Jae Lim; Masayoshi Mishima; Tohru Masuyama
Elevation of plasma brain natriuretic peptide is a hallmark of diastolic heart failure independent of ventricular hypertrophy.
Journal of the American College of Cardiology 2004;43(1):55-60.
2003: Kazuhiro Yamamoto; Nagahiro Nishikawa; Toshiaki Mano; Yasushi Sakata; Junichi Yoshida; Seiko Umekawa; Masatsugu Hori; Yuki Yasuhara; Tohru Masuyama
Instantaneous assessment of left ventricular midwall mechanics with tissue Doppler tracking technique.
Journal of cardiac failure 2003;9(5):392-7.
2003: Yasushi Sakata; Kazuhiro Yamamoto; Toshiaki Mano; Nagahiro Nishikawa; Junichi Yoshida; Hiroyuki Nakayama; Kinya Otsu; Keiichiro Suzuki; Michihiko Tada; Masatsugu Hori; Takeshi Miwa; Tohru Masuyama
Angiotensin II type 1 receptor blockade prevents diastolic heart failure through modulation of Ca(2+) regulatory proteins and extracellular matrix.
Journal of hypertension 2003;21(9):1737-45.
2003: Yoshiharu Higuchi; Kinya Otsu; Kazuhiko Nishida; Shinichi Hirotani; Hiroyuki Nakayama; Osamu Yamaguchi; Shungo Hikoso; Kazunori Kashiwase; Toshihiro Takeda; Tetsuya Watanabe; Toshiaki Mano; Yasushi Matsumura; Hikaru Ueno; Masatsugu Hori
The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B.
The Journal of biological chemistry 2003;278(23):20770-7.
2003: Nagahiro Nishikawa; Kazuhiro Yamamoto; Yasushi Sakata; Toshiaki Mano; Junichi Yoshida; Takeshi Miwa; Hiroshi Takeda; Masatsugu Hori; Tohru Masuyama
Differential activation of matrix metalloproteinases in heart failure with and without ventricular dilatation.
Cardiovascular research 2003;57(3):766-74.
2003: Yasushi Sakata; Kazuhiro Yamamoto; Toshiaki Mano; Nagahiro Nishikawa; Junichi Yoshida; Takeshi Miwa; Masatsugu Hori; Tohru Masuyama
Temocapril prevents transition to diastolic heart failure in rats even if initiated after appearance of LV hypertrophy and diastolic dysfunction.
Cardiovascular research 2003;57(3):757-65.
2003: Junichi Yoshida; Kazuhiro Yamamoto; Toshiaki Mano; Yasushi Sakata; Nagahiro Nishikawa; Takeshi Miwa; Masatsugu Hori; Tohru Masuyama
Angiotensin II type 1 and endothelin type A receptor antagonists modulate the extracellular matrix regulatory system differently in diastolic heart failure.
Journal of hypertension 2003;21(2):437-44.
2002: Kazuhiro Yamamoto; Tohru Masuyama; Yasushi Sakata; Nagahiro Nishikawa; Toshiaki Mano; Junichi Yoshida; Takeshi Miwa; Motoaki Sugawara; Yukihiro Yamaguchi; Tomomi Ookawara; Keiichiro Suzuki; Masatsugu Hori
Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart.
Cardiovascular research 2002;55(1):76-82.
2002: Kazuhiro Yamamoto; Tohru Masuyama; Yasushi Sakata; Nagahiro Nishikawa; Toshiaki Mano; Masatsugu Hori
Prevention of diastolic heart failure by endothelin type A receptor antagonist through inhibition of ventricular structural remodeling in hypertensive heart.
Journal of hypertension 2002;20(4):753-61.
2002: Keiko Ono; Tohru Masuyama; Kazuhiro Yamamoto; Reiko Doi; Yasushi Sakata; Nagahiro Nishikawa; Toshiaki Mano; Tsunehiko Kuzuya; Hiroshi Takeda; Masatsugu Hori
Echo doppler assessment of left ventricular function in rats with hypertensive hypertrophy.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2002;15(2):109-17.
2002: Shinichi Hirotani; Kinya Otsu; Kazuhiko Nishida; Yoshiharu Higuchi; Takashi Morita; Hiroyuki Nakayama; Osamu Yamaguchi; Toshiaki Mano; Yasushi Matsumura; Hikaru Ueno; Michihiko Tada; Masatsugu Hori
Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy.
Circulation 2002;105(4):509-15.
2002: Tohru Masuyama; Kazuhiro Yamamoto; Nagahiro Nishikawa; Yasushi Sakata; Toshiaki Mano; Masatsugu Hori; Teruyuki Sonoyama; Takashi Ito; Yoshihiro Yoshikawa
New attempt of ultrasonic tissue characterization: decreased chaos in myocardial echo in patients with dilated cardiomyopathy.
Ultrasound in medicine & biology 2002;28(1):93-9.
2001: Nagahiro Nishikawa; Tohru Masuyama; Kazuhiro Yamamoto; Yasushi Sakata; Toshiaki Mano; Takeshi Miwa; Motoaki Sugawara; Masatsugu Hori
Long-term administration of amlodipine prevents decompensation to diastolic heart failure in hypertensive rats.
Journal of the American College of Cardiology 2001;38(5):1539-45.
2001: Yasushi Sakata; Kazuhiro Yamamoto; Tohru Masuyama; Toshiaki Mano; Nagahiro Nishikawa; Tsunehiko Kuzuya; Takeshi Miwa; Masatsugu Hori
Ventricular production of natriuretic peptides and ventricular structural remodeling in hypertensive heart failure.
Journal of hypertension 2001;19(10):1905-12.
2001: Yasushi Sakata; Tohru Masuyama; Kazuhiro Yamamoto; Reiko Doi; Toshiaki Mano; Tsunehiko Kuzuya; Takeshi Miwa; Hiroshi Takeda; Masatsugu Hori
Renin angiotensin system-dependent hypertrophy as a contributor to heart failure in hypertensive rats: different characteristics from renin angiotensin system-independent hypertrophy.
Journal of the American College of Cardiology 2001;37(1):293-9.
2000: Kazuhiro Yamamoto; Tohru Masuyama; Yasushi Sakata; Toshiaki Mano; Nagahiro Nishikawa; H Kondo; Noriyuki Akehi; Tsunehiko Kuzuya; Takeshi Miwa; Masatsugu Hori
Roles of renin-angiotensin and endothelin systems in development of diastolic heart failure in hypertensive hearts.
Cardiovascular research 2000;47(2):274-83.
2000: Kazuhiro Yamamoto; Tohru Masuyama; Yasushi Sakata; Reiko Doi; Keiko Ono; Toshiaki Mano; H Kondo; Tsunehiko Kuzuya; Takeshi Miwa; Masatsugu Hori
Local neurohumoral regulation in the transition to isolated diastolic heart failure in hypertensive heart disease: absence of AT1 receptor downregulation and 'overdrive' of the endothelin system.
Cardiovascular research 2000;46(3):421-32.
2000: Reiko Doi; Tohru Masuyama; Kazuhiro Yamamoto; Y Doi; Toshiaki Mano; Yasushi Sakata; Keiko Ono; Tsunehiko Kuzuya; S Hirota; T Koyama; Takeshi Miwa; Masatsugu Hori
Development of different phenotypes of hypertensive heart failure: systolic versus diastolic failure in Dahl salt-sensitive rats.
Journal of hypertension 2000;18(1):111-20.