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Stavros Manolagas

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Stavros C Manolagas; A Michael Parfitt
For whom the bell tolls: distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases.
Stavros C Manolagas
Steroids and osteoporosis: the quest for mechanisms.
Shoshana M Bartell; Ken L Chambliss; Li Han; Robert L Jilka; Benita S Katzenellenbogen; John A Katzenellenbogen; Ha-neui Kim; Sung Hoon Kim; Paula K Roberson; Philip W Shaul; Robert S Weinstein; Maria Almeida; Stavros C Manolagas
Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass.

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All Publications

2013: Stavros C Manolagas; A Michael Parfitt
For whom the bell tolls: distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases.
Bone 2013;54(2):272-8.
2013: Stavros C Manolagas
Steroids and osteoporosis: the quest for mechanisms.
The Journal of clinical investigation 2013;123(5):1919-21.
2013: Shoshana M Bartell; Ken L Chambliss; Li Han; Robert L Jilka; Benita S Katzenellenbogen; John A Katzenellenbogen; Ha-neui Kim; Sung Hoon Kim; Paula K Roberson; Philip W Shaul; Robert S Weinstein; Maria Almeida; Stavros C Manolagas
Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass.
Molecular endocrinology (Baltimore, Md.) 2013;27(4):649-56.
2013: Maria Almeida; Elena Ambrogini; Shoshana M Bartell; Li Han; Srividhya Iyer; Robert L Jilka; Marta Martin-Millan; Charles A O'Brien; Melda Onal; Robert S Weinstein; Jinhu Xiong; Stavros C Manolagas
Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual.
The Journal of clinical investigation 2013;123(1):394-404.
2012: Melda Onal; Jeff D Thostenson; Jinhu Xiong; Maria Almeida; Xinrong Chen; Stavros C Manolagas; Charles A O'Brien
Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss.
The Journal of biological chemistry 2012;287(35):29851-60.
2012: Melda Onal; Robert S Weinstein; Jinhu Xiong; Qiang Fu; Carlo Galli; Stavros C Manolagas; Charles A O'Brien
The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice.
Molecular endocrinology (Baltimore, Md.) 2012;26(2):341-8.
2011: Jinhu Xiong; Robert L Jilka; Stavros C Manolagas; Melda Onal; Robert S Weinstein; Charles A O'Brien
Matrix-embedded cells control osteoclast formation.
Nature medicine 2011;17(10):1235-41.
2011: Robert S Weinstein; Haibo Zhao; Maria Almeida; Robert L Jilka; Charles A O'Brien; Paula K Roberson; Stavros C Manolagas
Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice.
Endocrinology 2011;152(9):3323-31.
2011: Shiqiao Ye; Minghao Zheng; Yunfeng Feng; Tristan W Fowler; Richard C Kurten; Kai Liang; Stavros C Manolagas; Pei Ying Ng; Nathan J Pavlos; Haibo Zhao
LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1.
PloS one 2011;6(11):e27285.
2010: Robert L Jilka; Charles A O'Brien; Shoshana M Bartell; Robert S Weinstein; Stavros C Manolagas
Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010;25(11):2427-37.
2010: Maria Almeida; Li Han; Elena Ambrogini; Shoshana M Bartell; Stavros C Manolagas
Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens.
Molecular endocrinology (Baltimore, Md.) 2010;24(10):2030-7.
2010: Robert S Weinstein; Robert L Jilka; Maria Almeida; Paula K Roberson; Stavros C Manolagas
Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice.
Endocrinology 2010;151(6):2641-9.
2010: Stavros C Manolagas; A Michael Parfitt
What old means to bone.
Trends in endocrinology and metabolism: TEM 2010;21(6):369-74.
2010: Stavros C Manolagas
From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis.
Endocrine reviews 2010;31(3):266-300.
2010: Maria Almeida; Marta Martin-Millan; Elena Ambrogini; Robert Bradsher; Li Han; Xiao-Dong Chen; Paula K Roberson; Robert S Weinstein; Charles A O'Brien; Robert L Jilka; Stavros C Manolagas
Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010;25(4):769-81.
2010: Elena Ambrogini; Maria Almeida; Marta Martin-Millan; Ji-Hye Paik; Ronald A DePinho; Li Han; Joseph Goellner; Robert S Weinstein; Robert L Jilka; Charles A O'Brien; Stavros C Manolagas
FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.
Cell metabolism 2010;11(2):136-46.
2010: Marta Martin-Millan; Maria Almeida; Elena Ambrogini; Li Han; Haibo Zhao; Robert S Weinstein; Robert L Jilka; Charles A O'Brien; Stavros C Manolagas
The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone.
Molecular endocrinology (Baltimore, Md.) 2010;24(2):323-34.
2010: Anenisia C Andrade; Jeffrey Baron; Stavros C Manolagas; Nick J Shaw; Gudrun A Rappold; Malcolm D C Donaldson; Emma Jane Gault; Lars Sävendahl
Hormones and genes of importance in bone physiology and their influence on bone mineralization and growth in Turner syndrome.
Hormone research in pædiatrics 2010;73(3):161-5.
2009: Maria Almeida; Elena Ambrogini; Li Han; Stavros C Manolagas; Robert L Jilka
Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton.
The Journal of biological chemistry 2009;284(40):27438-48.
2009: Carlo Galli; Qiang Fu; Wenfang Wang; Bjorn R Olsen; Stavros C Manolagas; Robert L Jilka; Charles A O'Brien
Commitment to the osteoblast lineage is not required for RANKL gene expression.
The Journal of biological chemistry 2009;284(19):12654-62.
2009: Robert L Jilka; Charles A O'Brien; A Afshan Ali; Paula K Roberson; Robert S Weinstein; Stavros C Manolagas
Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts.
Bone 2009;44(2):275-86.
2009: Robert S Weinstein; Paula K Roberson; Stavros C Manolagas
Giant osteoclast formation and long-term oral bisphosphonate therapy.
The New England journal of medicine 2009;360(1):53-62.
2008: Lilian I Plotkin; Virginia Lezcano; Jeff Thostenson; Robert S Weinstein; Stavros C Manolagas; Teresita Bellido
Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(11):1712-21.
2008: Stavros C Manolagas
De-fense! De-fense! De-fense: scavenging H2O2 while making cholesterol.
Endocrinology 2008;149(7):3264-6.
2008: Charles A O'Brien; Lilian Plotkin; Carlo Galli; Joseph J Goellner; Arancha R Gortazar; Matthew R Allen; Alexander G Robling; Mary L Bouxsein; Ernestina Schipani; Charles H Turner; Robert L Jilka; Robert S Weinstein; Stavros C Manolagas; Teresita Bellido
Control of bone mass and remodeling by PTH receptor signaling in osteocytes.
PloS one 2008;3(8):e2942.
2008: Carlo Galli; Lee A Zella; Jackie A Fretz; Qiang Fu; J Wesley Pike; Robert S Weinstein; Stavros C Manolagas; Charles A O'Brien
Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass.
Endocrinology 2008;149(1):146-53.
2007: Xiao-Dong Chen; Vladimir Dusevich; Jian Q Feng; Stavros C Manolagas; Robert L Jilka
Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(12):1943-56.
2007: Stavros C Manolagas; Maria Almeida
Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism.
Molecular endocrinology (Baltimore, Md.) 2007;21(11):2605-14.
2007: Robert L Jilka; Robert S Weinstein; A Michael Parfitt; Stavros C Manolagas
Quantifying osteoblast and osteocyte apoptosis: challenges and rewards.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(10):1492-501.
2007: Maria Almeida; Li Han; Marta Martin-Millan; Lilian Plotkin; Scott A Stewart; Paula K Roberson; Stavroula Kousteni; Charles A O'Brien; Teresita Bellido; A Michael Parfitt; Robert S Weinstein; Robert L Jilka; Stavros C Manolagas
Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids.
The Journal of biological chemistry 2007;282(37):27285-97.
2007: Maria Almeida; Li Han; Marta Martin-Millan; Charles A O'Brien; Stavros C Manolagas
Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.
The Journal of biological chemistry 2007;282(37):27298-305.
2007: J Ignacio Aguirre; Lilian Plotkin; Arancha R Gortazar; Marta Martin Millan; Charles A O'Brien; Stavros C Manolagas; Teresita Bellido
A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction.
The Journal of biological chemistry 2007;282(35):25501-8.
2007: Lilian Plotkin; Stavros C Manolagas; Teresita Bellido
Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis.
The Journal of biological chemistry 2007;282(33):24120-30.
2007: Dorota Szumska; Helen Benes; Ping Kang; Robert S Weinstein; Robert L Jilka; Stavros C Manolagas; Robert J Shmookler Reis
A novel locus on the X chromosome regulates post-maturity bone density changes in mice.
Bone 2007;40(3):758-66.
2007: Stavroula Kousteni; Maria Almeida; Li Han; Teresita Bellido; Robert L Jilka; Stavros C Manolagas
Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor.
Molecular and cellular biology 2007;27(4):1516-30.
2006: Dan Jia; Charles A O'Brien; Scott A Stewart; Stavros C Manolagas; Robert S Weinstein
Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density.
Endocrinology 2006;147(12):5592-9.
2006: Stavros C Manolagas; Robert L Jilka; Stavroula Kousteni; Teresita Bellido; Robert S Weinstein; Charles A O'Brien; Lilian Plotkin; Li Han
Response to Windahl et al.
The Journal of clinical investigation 2006;116(11):2834.
2006: Qiang Fu; Stavros C Manolagas; Charles A O'Brien
Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer.
Molecular and cellular biology 2006;26(17):6453-68.
2006: Lilian Plotkin; Stavros C Manolagas; Teresita Bellido
Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs.
Bone 2006;39(3):443-52.
2006: J Ignacio Aguirre; Lilian Plotkin; Scott A Stewart; Robert S Weinstein; A Michael Parfitt; Stavros C Manolagas; Teresita Bellido
Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(4):605-15.
2006: Maria Almeida; Li Han; Charles A O'Brien; Stavroula Kousteni; Stavros C Manolagas
Classical genotropic versus kinase-initiated regulation of gene transcription by the estrogen receptor alpha.
Endocrinology 2006;147(4):1986-96.
2005: Maria Almeida; Li Han; Teresita Bellido; Stavros C Manolagas; Stavroula Kousteni
Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.
The Journal of biological chemistry 2005;280(50):41342-51.
2005: Teresita Bellido; A Afshan Ali; Igor Gubrij; Lilian Plotkin; Qiang Fu; Charles A O'Brien; Stavros C Manolagas; Robert L Jilka
Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis.
Endocrinology 2005;146(11):4577-83.
2005: Charles A O'Brien; Robert L Jilka; Qiang Fu; Scott Stewart; Robert S Weinstein; Stavros C Manolagas
IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice.
American journal of physiology. Endocrinology and metabolism 2005;289(5):E784-93.
2005: Lilian Plotkin; Irina Mathov; J Ignacio Aguirre; A Michael Parfitt; Stavros C Manolagas; Teresita Bellido
Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs.
American journal of physiology. Cell physiology 2005;289(3):C633-43.
2005: Anthony M Vertino; Craig M Bula; Jin-Ran Chen; Maria Almeida; Li Han; Teresita Bellido; Stavroula Kousteni; Anthony W Norman; Stavros C Manolagas
Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases.
The Journal of biological chemistry 2005;280(14):14130-7.
2005: A Afshan Ali; Robert S Weinstein; Scott A Stewart; A Michael Parfitt; Stavros C Manolagas; Robert L Jilka
Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation.
Endocrinology 2005;146(3):1226-35.
2005: Lilian Plotkin; J Ignacio Aguirre; Stavroula Kousteni; Stavros C Manolagas; Teresita Bellido
Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation.
The Journal of biological chemistry 2005;280(8):7317-25.
2005: Jin-Ran Chen; Lilian Plotkin; J Ignacio Aguirre; Li Han; Robert L Jilka; Stavroula Kousteni; Teresita Bellido; Stavros C Manolagas
Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens.
The Journal of biological chemistry 2005;280(6):4632-8.
2004: Stavros C Manolagas; Stavroula Kousteni; Jin-Ran Chen; Maria Schuller; Lilian Plotkin; Teresita Bellido
Kinase-mediated transcription, activators of nongenotropic estrogen-like signaling (ANGELS), and osteoporosis: a different perspective on the HRT dilemma.
Kidney international. Supplement 2004;(91):S41-9.
2004: Robert S Weinstein; Dan Jia; Cara Powers; Scott A Stewart; Robert L Jilka; A Michael Parfitt; Stavros C Manolagas
The skeletal effects of glucocorticoid excess override those of orchidectomy in mice.
Endocrinology 2004;145(4):1980-7.
2004: Charles A O'Brien; Dan Jia; Lilian Plotkin; Teresita Bellido; Cara Powers; Scott A Stewart; Stavros C Manolagas; Robert S Weinstein
Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength.
Endocrinology 2004;145(4):1835-41.
2004: Jian Zhang; Jinlu Dai; Yi Lu; Zhi Yao; Charles A O'Brien; Jill Marie Keller; Weici Qi; Daniel E Hall; Stavros C Manolagas; William B. Ershler; Evan T Keller
In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging.
Experimental gerontology 2004;39(2):239-47.
2003: Teresita Bellido; A Afshan Ali; Lilian Plotkin; Qiang Fu; Igor Gubrij; Paula K Roberson; Robert S Weinstein; Charles A O'Brien; Stavros C Manolagas; Robert L Jilka
Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism.
The Journal of biological chemistry 2003;278(50):50259-72.
2003: Mohammad T Ijaz; Stavros C Manolagas
A patient with pseudohypoparathyroidism.
The Journal of the Arkansas Medical Society 2003;100(5):164-6.
2003: Stavroula Kousteni; Li Han; Jin-Ran Chen; Maria Almeida; Lilian Plotkin; Teresita Bellido; Stavros C Manolagas
Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids.
The Journal of clinical investigation 2003;111(11):1651-64.
2002: Qiang Fu; Robert L Jilka; Stavros C Manolagas; Charles A O'Brien
Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein.
The Journal of biological chemistry 2002;277(50):48868-75.
2002: Stavroula Kousteni; Jin-Ran Chen; Teresita Bellido; Li Han; A Afshan Ali; Charles A O'Brien; Lilian Plotkin; Qiang Fu; Anne Mancino; Yeshao Wen; Anthony M Vertino; Cara Powers; Scott A Stewart; R Ebert; A Michael Parfitt; Robert S Weinstein; Robert L Jilka; Stavros C Manolagas
Reversal of bone loss in mice by nongenotropic signaling of sex steroids.
Science (New York, N.Y.) 2002;298(5594):843-6.
2002: Beata Lecka-Czernik; Elena J Moerman; David F Grant; Jurgen Lehmann; Stavros C Manolagas; Robert L Jilka
Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation.
Endocrinology 2002;143(6):2376-84.
2002: Robert S Weinstein; Jin-Ran Chen; Cara Powers; Scott A Stewart; Reid D Landes; Teresita Bellido; Robert L Jilka; A Michael Parfitt; Stavros C Manolagas
Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids.
The Journal of clinical investigation 2002;109(8):1041-8.
2002: Lilian Plotkin; Stavros C Manolagas; Teresita Bellido
Transduction of cell survival signals by connexin-43 hemichannels.
The Journal of biological chemistry 2002;277(10):8648-57.
2002: Charles A O'Brien; B Kern; Igor Gubrij; G Karsenty; Stavros C Manolagas
Cbfa1 does not regulate RANKL gene activity in stromal/osteoblastic cells.
Bone 2002;30(3):453-62.
2002: Stavros C Manolagas; Stavroula Kousteni; Robert L Jilka
Sex steroids and bone.
Recent progress in hormone research 2002;57():385-409.
2002: Dana Gaddy-Kurten; J K Coker; Etsuko Abe; Robert L Jilka; Stavros C Manolagas
Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures.
Endocrinology 2002;143(1):74-83.
2001: Anne Mancino; V Suzanne Klimberg; M Yamamoto; Stavros C Manolagas; Etsuko Abe
Breast cancer increases osteoclastogenesis by secreting M-CSF and upregulating RANKL in stromal cells.
The Journal of surgical research 2001;100(1):18-24.
2001: Stavros C Manolagas; Stavroula Kousteni
Perspective: nonreproductive sites of action of reproductive hormones.
Endocrinology 2001;142(6):2200-4.
2001: Gina B Di Gregorio; M Yamamoto; A Afshan Ali; Etsuko Abe; Paula K Roberson; Stavros C Manolagas; Robert L Jilka
Attenuation of the self-renewal of transit-amplifying osteoblast progenitors in the murine bone marrow by 17 beta-estradiol.
The Journal of clinical investigation 2001;107(7):803-12.
2001: Stavroula Kousteni; Teresita Bellido; Lilian Plotkin; Charles A O'Brien; Donald L Bodenner; L Han; K Han; G B DiGregorio; J A Katzenellenbogen; Benita S Katzenellenbogen; Paula K Roberson; Robert S Weinstein; Robert L Jilka; Stavros C Manolagas
Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity.
Cell 2001;104(5):719-30.
2000: Charles A O'Brien; SC Lin; Teresita Bellido; Stavros C Manolagas
Expression levels of gp130 in bone marrow stromal cells determine the magnitude of osteoclastogenic signals generated by IL-6-type cytokines.
Journal of cellular biochemistry 2000;79(4):532-41.
2000: Teresita Bellido; Michael Huening; M Raval-Pandya; Stavros C Manolagas; Sylvia Christakos
Calbindin-D28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity.
The Journal of biological chemistry 2000;275(34):26328-32.
2000: Robert S Weinstein; Richard W Nicholas; Stavros C Manolagas
Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip.
The Journal of clinical endocrinology and metabolism 2000;85(8):2907-12.
2000: Etsuko Abe; M Yamamoto; Y Taguchi; Beata Lecka-Czernik; Charles A O'Brien; Aris N Economides; Neil stahl; Robert L Jilka; Stavros C Manolagas
Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(4):663-73.
2000: Helen Benes; Robert S Weinstein; W Zheng; John J Thaden; Robert L Jilka; Stavros C Manolagas; Robert J Shmookler Reis
Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(4):626-33.
1999: Lilian Plotkin; Robert S Weinstein; A Michael Parfitt; Paula K Roberson; Stavros C Manolagas; Teresita Bellido
Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin.
The Journal of clinical investigation 1999;104(10):1363-74.
1999: Andrew Grey; Mary Ann Mitnick; Urszula S Masiukiewicz; Ben-Hua Sun; S Rudikoff; Robert L Jilka; Stavros C Manolagas; Karl Insogna
A role for interleukin-6 in parathyroid hormone-induced bone resorption in vivo.
Endocrinology 1999;140(10):4683-90.
1999: Beata Lecka-Czernik; Igor Gubrij; Elena J Moerman; O Kajkenova; David A Lipschitz; Stavros C Manolagas; Robert L Jilka
Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2.
Journal of cellular biochemistry 1999;74(3):357-71.
1999: Robert L Jilka; Robert S Weinstein; Teresita Bellido; Paula K Roberson; A Michael Parfitt; Stavros C Manolagas
Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone.
The Journal of clinical investigation 1999;104(4):439-46.
1999: Charles A O'Brien; Igor Gubrij; SC Lin; Robert L Saylors; Stavros C Manolagas
STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone.
The Journal of biological chemistry 1999;274(27):19301-8.
1999: Stavros C Manolagas; Robert S Weinstein
New developments in the pathogenesis and treatment of steroid-induced osteoporosis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(7):1061-6.
1999: Etsuko Abe; H Mocharla; T Yamate; Y Taguchi; Stavros C Manolagas
Meltrin-alpha, a fusion protein involved in multinucleated giant cell and osteoclast formation.
Calcified tissue international 1999;64(6):508-15.
1998: Stavros C Manolagas; R S Weinstein; Robert L Jilka; A Michael Parfitt
Parathyroid hormone and corticosteroid-induced osteoporosis.
Lancet 1998;352(9144):1940.
1998: Y Taguchi; M Yamamoto; T Yamate; SC Lin; H Mocharla; P DeTogni; N Nakayama; B F Boyce; Etsuko Abe; Stavros C Manolagas
Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage.
Proceedings of the Association of American Physicians 1998;110(6):559-74.
1998: Teresita Bellido; Charles A O'Brien; Paula K Roberson; Stavros C Manolagas
Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells.
The Journal of biological chemistry 1998;273(33):21137-44.
1998: Robert S Weinstein; Robert L Jilka; A Michael Parfitt; Stavros C Manolagas
Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.
The Journal of clinical investigation 1998;102(2):274-82.
1998: Stavros C Manolagas
The role of IL-6 type cytokines and their receptors in bone.
Annals of the New York Academy of Sciences 1998;840():194-204.
1998: Robert L Jilka; Robert S Weinstein; Teresita Bellido; A Michael Parfitt; Stavros C Manolagas
Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(5):793-802.
1998: Robert L Jilka; K Takahashi; M Munshi; D C Williams; Paula K Roberson; Stavros C Manolagas
Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption.
The Journal of clinical investigation 1998;101(9):1942-50.
1997: O Kajkenova; Beata Lecka-Czernik; Igor Gubrij; SP Hauser; K Takahashi; A Michael Parfitt; Robert L Jilka; Stavros C Manolagas; David A Lipschitz
Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(11):1772-9.
1997: SC Lin; T Yamate; Y Taguchi; V Z Borba; G Girasole; Charles A O'Brien; Teresita Bellido; Etsuko Abe; Stavros C Manolagas
Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow.
The Journal of clinical investigation 1997;100(8):1980-90.
1997: Robert S Weinstein; Robert L Jilka; A Michael Parfitt; Stavros C Manolagas
The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage.
Endocrinology 1997;138(9):4013-21.
1997: Teresita Bellido; V Z Borba; Paula K Roberson; Stavros C Manolagas
Activation of the Janus kinase/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation.
Endocrinology 1997;138(9):3666-76.
1997: T Yamate; H Mocharla; Y Taguchi; Joseph U Igietseme; Stavros C Manolagas; Etsuko Abe
Osteopontin expression by osteoclast and osteoblast progenitors in the murine bone marrow: demonstration of its requirement for osteoclastogenesis and its increase after ovariectomy.
Endocrinology 1997;138(7):3047-55.
1997: Charles A O'Brien; Stavros C Manolagas
Isolation and characterization of the human gp130 promoter. Regulation by STATS.
The Journal of biological chemistry 1997;272(23):15003-10.
1997: H Mocharla; Anthony W Butch; AA Pappas; JT Flick; Robert S Weinstein; P De Togni; Robert L Jilka; Paula K Roberson; A Michael Parfitt; Stavros C Manolagas
Quantification of vitamin D receptor mRNA by competitive polymerase chain reaction in PBMC: lack of correspondence with common allelic variants.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(5):726-33.
1996: Robert L Jilka; Robert S Weinstein; K Takahashi; A Michael Parfitt; Stavros C Manolagas
Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence.
The Journal of clinical investigation 1996;97(7):1732-40.
1996: Teresita Bellido; Neil stahl; T J Farruggella; V Borba; George D Yancopoulos; Stavros C Manolagas
Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells.
The Journal of clinical investigation 1996;97(2):431-7.
1995: X P Yu; Teresita Bellido; Stavros C Manolagas
Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):10990-4.
1995: Stavros C Manolagas
Role of cytokines in bone resorption.
Bone 1995;17(2 Suppl):63S-67S.
1995: Teresita Bellido; Robert L Jilka; B F Boyce; Giuseppe Girasole; H Broxmeyer; S A Dalrymple; R Murray; Stavros C Manolagas
Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.
The Journal of clinical investigation 1995;95(6):2886-95.
1995: Robert L Jilka; Giovanni Passeri; Giuseppe Girasole; S Cooper; J Abrams; H Broxmeyer; Stavros C Manolagas
Estrogen loss upregulates hematopoiesis in the mouse: a mediating role of IL-6.
Experimental hematology 1995;23(6):500-6.
1995: Stavros C Manolagas; Robert L Jilka
Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis.
The New England journal of medicine 1995;332(5):305-11.
1995: Stavros C Manolagas; Teresita Bellido; Robert L Jilka
New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis: roles of IL-6 and gp130.
International journal of immunopharmacology 1995;17(2):109-16.
1995: Stavros C Manolagas; Teresita Bellido; Robert L Jilka
Sex steroids, cytokines and the bone marrow: new concepts on the pathogenesis of osteoporosis.
Ciba Foundation symposium 1995;191():187-96; discussion 197-202.
1995: Stavros C Manolagas
Bone marrow, clastic, and blastic cell system: quo vadis?
Calcified tissue international 1995;56 Suppl 1():S52-3.
1994: Giuseppe Girasole; Giovanni Passeri; Robert L Jilka; Stavros C Manolagas
Interleukin-11: a new cytokine critical for osteoclast development.
The Journal of clinical investigation 1994;93(4):1516-24.
1994: Stavros C Manolagas; X P Yu; Giuseppe Girasole; Teresita Bellido
Vitamin D and the hematolymphopoietic tissue: a 1994 update.
Seminars in nephrology 1994;14(2):129-43.
1994: S T Pottratz; Teresita Bellido; H Mocharla; D Crabb; Stavros C Manolagas
17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism.
The Journal of clinical investigation 1994;93(3):944-50.
1994: Giovanni Passeri; Giuseppe Girasole; Stavros C Manolagas; Robert L Jilka
Endogenous production of tumor necrosis factor by primary cultures of murine calvarial cells: influence on IL-6 production and osteoclast development.
Bone and mineral 1994;24(2):109-26.
1993: Giovanni Passeri; Giuseppe Girasole; Robert L Jilka; Stavros C Manolagas
Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal.
Endocrinology 1993;133(2):822-8.
1993: Teresita Bellido; Giuseppe Girasole; Giovanni Passeri; X P Yu; H Mocharla; Robert L Jilka; A Notides; Stavros C Manolagas
Demonstration of estrogen and vitamin D receptors in bone marrow-derived stromal cells: up-regulation of the estrogen receptor by 1,25-dihydroxyvitamin-D3.
Endocrinology 1993;133(2):553-62.
1993: Y Sakagami; Giuseppe Girasole; X P Yu; H S Boswell; Stavros C Manolagas
Stimulation of interleukin-6 production by either calcitonin gene-related peptide or parathyroid hormone in two phenotypically distinct bone marrow-derived murine stromal cell lines.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(7):811-6.
1993: Stavros C Manolagas; Robert L Jilka; Giuseppe Girasole; Giovanni Passeri; Teresita Bellido
Estrogen, cytokines, and the control of osteoclast formation and bone resorption in vitro and in vivo.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1993;3 Suppl 1():114-6.
1993: F G Hustmyer; E Walker; X P Yu; Giuseppe Girasole; Y Sakagami; M Peacock; Stavros C Manolagas
Cytokine production and surface antigen expression by peripheral blood mononuclear cells in postmenopausal osteoporosis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(1):51-9.
1992: F G Hustmyer; Giuseppe Girasole; Stavros C Manolagas
Signal-dependent pleiotropic regulation of lymphocyte proliferation and cytokine production by 1,25-dihydroxyvitamin D3: potent modulation of the hormonal effects by phorbol esters.
Immunology 1992;77(4):520-6.
1992: Robert L Jilka; Giao Hangoc; Giuseppe Girasole; Giovanni Passeri; D C Williams; J S Abrams; B Boyce; H Broxmeyer; Stavros C Manolagas
Increased osteoclast development after estrogen loss: mediation by interleukin-6.
Science (New York, N.Y.) 1992;257(5066):88-91.
1992: Giuseppe Girasole; Robert L Jilka; Giovanni Passeri; S Boswell; G Boder; D C Williams; Stavros C Manolagas
17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens.
The Journal of clinical investigation 1992;89(3):883-91.
1991: X P Yu; F G Hustmyer; W T Garvey; Stavros C Manolagas
Demonstration of a 1,25-dihydroxyvitamin D3-responsive protein in human lymphocytes: immunologic crossreactivity and inverse regulation with the vitamin D receptor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8347-51.
1991: X P Yu; H Mocharla; F G Hustmyer; Stavros C Manolagas
Vitamin D receptor expression in human lymphocytes. Signal requirements and characterization by western blots and DNA sequencing.
The Journal of biological chemistry 1991;266(12):7588-95.
1990: Stavros C Manolagas; F G Hustmyer; X P Yu
Immunomodulating properties of 1,25-dihydroxyvitamin D3.
Kidney international. Supplement 1990;29():S9-16.
1990: Elsa J Brochmann Murray; Samuel S Murray; Stavros C Manolagas
Two-dimensional gel autoradiographic analyses of the effects of 1,25-dihydroxycholecalciferol on protein synthesis in clonal rat osteosarcoma cells.
Endocrinology 1990;126(5):2679-92.
1989: Stavros C Manolagas; F G Hustmyer; X P Yu
1,25-Dihydroxyvitamin D3 and the immune system.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1989;191(3):238-45.
1989: Constantine D Tsoukas; D Watry; S S Escobar; D M Provvedini; C A Dinarello; F G Hustmyer; Stavros C Manolagas
Inhibition of interleukin-1 production by 1,25-dihydroxyvitamin D3.
The Journal of clinical endocrinology and metabolism 1989;69(1):127-33.
1989: D M Provvedini; Stavros C Manolagas
1 Alpha,25-dihydroxyvitamin D3 receptor distribution and effects in subpopulations of normal human T lymphocytes.
The Journal of clinical endocrinology and metabolism 1989;68(4):774-9.
1989: D M Provvedini; Y Sakagami; Stavros C Manolagas
Distinct target cells and effects of 1 alpha,25-dihydroxyvitamin D3 and glucocorticoids in the rat thymus gland.
Endocrinology 1989;124(3):1532-8.
1987: Stavros C Manolagas
Vitamin D and its revelance to cancer.
Anticancer research 1987;7(4A):625-38.
1987: D M Provvedini; C M Rulot; R E Sobol; Constantine D Tsoukas; Stavros C Manolagas
1 alpha,25-Dihydroxyvitamin D3 receptors in human thymic and tonsillar lymphocytes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1987;2(3):239-47.
1987: Stavros C Manolagas; D M Provvedini; Elsa J Brochmann Murray; Samuel S Murray; P A Tsonis; D A Spandidos
Association between the expression of the c-myc oncogene mRNA and the expression of the receptor protein for 1,25-dihydroxyvitamin D3.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(3):856-60.
1986: Stavros C Manolagas; D A Werntz; Constantine D Tsoukas; D M Provvedini; J H Vaughan
1,25-Dihydroxyvitamin D3 receptors in lymphocytes from patients with rheumatoid arthritis.
The Journal of laboratory and clinical medicine 1986;108(6):596-600.
1986: Stavros C Manolagas; D M Provvedini; Elsa J Brochmann Murray; Constantine D Tsoukas; L J Deftos
The antiproliferative effect of calcitriol on human peripheral blood mononuclear cells.
The Journal of clinical endocrinology and metabolism 1986;63(2):394-400.
1986: D M Provvedini; Constantine D Tsoukas; L J Deftos; Stavros C Manolagas
1 alpha,25-Dihydroxyvitamin D3-binding macromolecules in human B lymphocytes: effects on immunoglobulin production.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(8):2734-40.
1986: Penelope A Morel; Stavros C Manolagas; D M Provvedini; D R Wegmann; J M Chiller
Interferon-gamma-induced IA expression in WEHI-3 cells is enhanced by the presence of 1,25-dihydroxyvitamin D3.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(6):2181-6.
1986: D M Provvedini; L J Deftos; Stavros C Manolagas
1,25-Dihydroxyvitamin D3 promotes in vitro morphologic and enzymatic changes in normal human monocytes consistent with their differentiation into macrophages.
Bone 1986;7(1):23-8.
1985: Stavros C Manolagas; D M Provvedini; Constantine D Tsoukas
Interactions of 1,25-dihydroxyvitamin D3 and the immune system.
Molecular and cellular endocrinology 1985;43(2-3):113-22.
1984: Constantine D Tsoukas; D M Provvedini; Stavros C Manolagas
1,25-dihydroxyvitamin D3: a novel immunoregulatory hormone.
Science (New York, N.Y.) 1984;224(4656):1438-40.
1984: D M Provvedini; L J Deftos; Stavros C Manolagas
1,25-Dihydroxyvitamin D3 receptors in a subset of mitotically active lymphocytes from rat thymus.
Biochemical and biophysical research communications 1984;121(1):277-83.
1983: D M Provvedini; Constantine D Tsoukas; L J Deftos; Stavros C Manolagas
1,25-dihydroxyvitamin D3 receptors in human leukocytes.
Science (New York, N.Y.) 1983;221(4616):1181-3.