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Ed Manser
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Research Profile (preview)
Chemicals & Drugs
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Genes & Molecular Sequences
Phenomena
Living Beings
Anatomy
Physiology
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Network (preview)
23
Lim, Louis
22
Leung, Thomas
11
Zhao, Zhuo-Shen
7
Dong, Jing-Ming
5
Chen, Xiang-qun
4
Loo, Tsui-Han
4
Koh, Cheng-Gee
3
Tan, Ivan
3
Tan, L
2
Zeng, Qi
2
Monfries, Clinton
1
Zhu, Yimin
1
Tang, Jing Ping
1
Teo, Tian Seng
1
Wang, Xin-Sheng
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All Publications
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2009: Teng Terk Shin; Lin Baohong; Manser Ed; Ng Dominic Chi Hiung; Cao Xinmin
Stat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIX.
Journal of cell science 2009;122(Pt 22):4150-9.
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2009: Chan Wing; Tian Rui; Lee Yeow-Fong; Sit Soon Tuck; Lim Louis; Manser Ed
Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.
The Journal of biological chemistry 2009;284(12):8185-94.
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2009: Dong Jing-Ming; Lau Lei-Shong; Ng Yuen-Wai; Lim Louis; Manser Ed
Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4 motif: evidence that nuclear paxillin promotes cell proliferation.
The Biochemical journal 2009;418(1):173-84.
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2009: Bahri Sami M; Choy Juliana M; Manser Edward; Lim Louis; Yang Xiaohang
The Drosophila homologue of Arf-GAP GIT1, dGIT, is required for proper muscle morphogenesis and guidance during embryogenesis.
Developmental biology 2009;325(1):15-23.
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2008: Chan Perry M; Lim Louis; Manser Edward
PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.
The Journal of biological chemistry 2008;283(36):24949-61.
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2008: Xie Yi; Tan E-Jean; Wee Shimei; Manser Edward; Lim Louis; Koh Cheng-Gee
Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways.
Journal of cell science 2008;121(Pt 4):514-21.
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2007: Wang Haihe; Quah Samantha Yiling; Dong Jing Ming; Manser Edward; Tang Jing Ping; Zeng Qi
PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition.
Cancer research 2007;67(7):2922-6.
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2005: Zhao Zhuo-Shen; Lim Jet Phey; Ng Yuen-Wai; Lim Louis; Manser Ed
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.
Molecular cell 2005;20(2):237-49.
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2005: Yeow-Fong Lee; Lim Louis; Manser Ed
SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1.
FEBS letters 2005;579(22):5040-8.
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2005: Zhao Zhou-shen; Manser Ed
PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation.
The Biochemical journal 2005;386(Pt 2):201-14.
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2004: Zhu Yimin; Stolz Donna B; Guo Fengli; Ross Mark A; Watkins Simon C; Tan Bee Jen; Qi Robert Z; Manser Ed; Li Qiu Tian; Bay Boon Huat; Teo Tian Seng; Duan Wei
Signaling via a novel integral plasma membrane pool of a serine/threonine protein kinase PRK1 in mammalian cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1722-4.
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2004: Loo Tsui-Han; Ng Yuen-Wai; Lim Louis; Manser Ed
GIT1 activates p21-activated kinase through a mechanism independent of p21 binding.
Molecular and cellular biology 2004;24(9):3849-59.
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2003: Gisler Serge M; Pribanic Sandra; Bacic Desa; Forrer Patrik; Gantenbein Andrea; Sabourin Luc A; Tsuji Akira; Zhao Zhuo-Shen; Manser Edward; Biber Jürg; Murer Heini
PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.
Kidney international 2003;64(5):1733-45.
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2003: Zeng Qi; Dong Jing-Ming; Guo Ke; Li Jie; Tan Hui-Xian; Koh Vicki; Pallen Catherine J; Manser Edward; Hong Wanjin
PRL-3 and PRL-1 promote cell migration, invasion, and metastasis.
Cancer research 2003;63(11):2716-22.
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2002: Chan Wing; Kozma Robert; Yasui Yoshihiro; Inagaki Masaki; Leung Thomas; Manser Ed; Lim Louis
Vimentin intermediate filament reorganization by Cdc42: involvement of PAK and p70 S6 kinase.
European journal of cell biology 2002;81(12):692-701.
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2002: Manser Ed
Small GTPases take the stage.
Developmental cell 2002;3(3):323-8.
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2002: Ong W Y; Wang X S; Manser E
Differential distribution of alpha and beta isoforms of p21-activated kinase in the monkey cerebral neocortex and hippocampus.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2002;144(2):189-99.
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2002: Dong Jing-Ming; Leung Thomas; Manser Edward; Lim Louis
Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation.
European journal of cell biology 2002;81(4):231-42.
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2002: Koh Cheng-Gee; Tan E-Jean; Manser Edward; Lim Louis
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.
Current biology : CB 2002;12(4):317-21.
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2002: Manser Edward J
The GTPase cycle. How dominant inhibitory mutants block the biological functions of small GTPases.
Methods in molecular biology (Clifton, N.J.) 2002;189():3-11.
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2001: Koh C G; Manser E; Zhao Z S; Ng C P; Lim L
Beta1PIX, the PAK-interacting exchange factor, requires localization via a coiled-coil region to promote microvillus-like structures and membrane ruffles.
Journal of cell science 2001;114(Pt 23):4239-51.
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2001: Zhao Z; Lim L; Manser E
Blot overlays with 32P-labeled fusion proteins.
Methods (San Diego, Calif.) 2001;24(3):194-200.
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2001: Chong C; Tan L; Lim L; Manser E
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.
The Journal of biological chemistry 2001;276(20):17347-53.
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2001: Teo M; Tan L; Lim L; Manser E
The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors.
The Journal of biological chemistry 2001;276(21):18392-8.
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2000: Zhao Z S; Manser E; Loo T H; Lim L
Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly.
Molecular and cellular biology 2000;20(17):6354-63.
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2000: Zhao Z S; Manser E; Lim L
Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation.
Molecular and cellular biology 2000;20(11):3906-17.
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1999: Manser E; Lim L
Roles of PAK family kinases.
Progress in molecular and subcellular biology 1999;22():115-33.
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1998: Dong J M; Leung T; Manser E; Lim L
cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha.
The Journal of biological chemistry 1998;273(35):22554-62.
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1998: Obermeier A; Ahmed S; Manser E; Yen S C; Hall C; Lim L
PAK promotes morphological changes by acting upstream of Rac.
The EMBO journal 1998;17(15):4328-39.
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1998: Zhao Z S; Manser E; Chen X Q; Chong C; Leung T; Lim L
A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.
Molecular and cellular biology 1998;18(4):2153-63.
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1998: Manser E; Loo T H; Koh C G; Zhao Z S; Chen X Q; Tan L; Tan I; Leung T; Lim L
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.
Molecular cell 1998;1(2):183-92.
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1998: Leung T; Chen X Q; Tan I; Manser E; Lim L
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.
Molecular and cellular biology 1998;18(1):130-40.
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1998: Manser E; Leung T; Lim L
Identification and characterization of small GTPase-associated kinases.
Methods in molecular biology (Clifton, N.J.) 1998;84():295-305.
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1997: Manser E; Huang H Y; Loo T H; Chen X Q; Dong J M; Leung T; Lim L
Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.
Molecular and cellular biology 1997;17(3):1129-43.
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1996: Lim L; Manser E; Leung T; Hall C
Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways.
European journal of biochemistry / FEBS 1996;242(2):171-85.
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1996: Leung T; Chen X Q; Manser E; Lim L
The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton.
Molecular and cellular biology 1996;16(10):5313-27.
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1996: Harden N; Lee J; Loh H Y; Ong Y M; Tan I; Leung T; Manser E; Lim L
A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures.
Molecular and cellular biology 1996;16(5):1896-908.
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1995: Leung T; Manser E; Tan L; Lim L
A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes.
The Journal of biological chemistry 1995;270(49):29051-4.
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1995: Teo M; Manser E; Lim L
Identification and molecular cloning of a p21cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets.
The Journal of biological chemistry 1995;270(44):26690-7.
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1995: Zhao Z S; Leung T; Manser E; Lim L
Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24.
Molecular and cellular biology 1995;15(10):5246-57.
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1995: Manser E; Chong C; Zhao Z S; Leung T; Michael G; Hall C; Lim L
Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family.
The Journal of biological chemistry 1995;270(42):25070-8.
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1995: Prigmore E; Ahmed S; Best A; Kozma R; Manser E; Segal A W; Lim L
A 68-kDa kinase and NADPH oxidase component p67phox are targets for Cdc42Hs and Rac1 in neutrophils.
The Journal of biological chemistry 1995;270(18):10717-22.
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1995: Manser E; Leung T; Lim L
Purification and assay of kinases that interact with Rac/Cdc42.
Methods in enzymology 1995;256():215-27.
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1995: Manser E; Leung T; Lim L
Identification of GTPase-activating proteins by nitrocellulose overlay assay.
Methods in enzymology 1995;256():130-9.
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1994: Leung T; How B E; Manser E; Lim L
Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain.
The Journal of biological chemistry 1994;269(17):12888-92.
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1994: Manser E; Leung T; Salihuddin H; Zhao Z S; Lim L
A brain serine/threonine protein kinase activated by Cdc42 and Rac1.
Nature 1994;367(6458):40-6.
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1993: Tan E C; Leung T; Manser E; Lim L
The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins.
The Journal of biological chemistry 1993;268(36):27291-8.
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1993: Hall C; Sin W C; Teo M; Michael G J; Smith P; Dong J M; Lim H H; Manser E; Spurr N K; Jones T A
Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes.
Molecular and cellular biology 1993;13(8):4986-98.
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1993: Manser E; Leung T; Salihuddin H; Tan L; Lim L
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42.
Nature 1993;363(6427):364-7.
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1993: Hall C; Manser E; Spurr N K; Lim L
Assignment of the human carboxypeptidase E (CPE) gene to chromosome 4.
Genomics 1993;15(2):461-3.
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1993: Leung T; How B E; Manser E; Lim L
Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis.
The Journal of biological chemistry 1993;268(6):3813-6.
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1992: Manser E; Leung T; Monfries C; Teo M; Hall C; Lim L
Diversity and versatility of GTPase activating proteins for the p21rho subfamily of ras G proteins detected by a novel overlay assay.
The Journal of biological chemistry 1992;267(23):16025-8.
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1991: Manser E; Fernandez D; Lim L
Processing and secretion of human carboxypeptidase E by C6 glioma cells.
The Biochemical journal 1991;280 ( Pt 3)():695-701.
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1990: Manser E; Fernandez D; Loo L; Goh P Y; Monfries C; Hall C; Lim L
Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro.
The Biochemical journal 1990;267(2):517-25.
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