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Tim Manser

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Neda Nikbakht; Shixue Shen; Tim Manser
Cutting edge: macrophages are required for localization of antigen-activated B cells to the follicular perimeter and the subsequent germinal center response.
Carlisle P Landel; Jennifer Dunlap; John B Patton; Tim Manser
A germline-competent embryonic stem cell line from NOD.Cg-Prkdc ( scid ) Il2rg ( tm1Wjl )/SzJ (NSG) mice.
Neda Nikbakht; Chris P Ward; Thi-Sau Migone; Tim Manser
Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments.

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All Publications

2013: Neda Nikbakht; Shixue Shen; Tim Manser
Cutting edge: macrophages are required for localization of antigen-activated B cells to the follicular perimeter and the subsequent germinal center response.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(10):4923-7.
2013: Carlisle P Landel; Jennifer Dunlap; John B Patton; Tim Manser
A germline-competent embryonic stem cell line from NOD.Cg-Prkdc ( scid ) Il2rg ( tm1Wjl )/SzJ (NSG) mice.
Transgenic research 2013;22(1):179-85.
2011: Neda Nikbakht; Chris P Ward; Thi-Sau Migone; Tim Manser
Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):37-46.
2009: Tanja Schwickert; Boris Alabyev; Tim Manser; Michel C Nussenzweig
Germinal center reutilization by newly activated B cells.
The Journal of experimental medicine 2009;206(13):2907-14.
2009: Raja Vuyyuru; Chandra Mohan; Tim Manser; Ziaur S M Rahman
The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):5716-27.
2009: Francis Coffey; Boris Alabyev; Tim Manser
Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles.
Immunity 2009;30(4):599-609.
2009: Xiaohe Liu; Shixue Shen; Tim Manser
Influence of B cell antigen receptor expression level on pathways of B cell tolerance induction.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):398-407.
2008: Boris Alabyev; Raja Vuyyuru; Tim Manser
Influence of Fas on the regulation of the response of an anti-nuclear antigen B cell clonotype to foreign antigen.
International immunology 2008;20(10):1279-87.
2007: Francis Coffey; Xiaohe Liu; Tim Manser
Primary development and participation in a foreign antigen-driven immune response of a chromatin-reactive B cell clonotype are not influenced by TLR9 or other MyD88-dependent TLRs.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6663-72.
2007: Ziaur S M Rahman; H Niu; D Perry; E Wakeland; Tim Manser; Laurence Morel
Expression of the autoimmune Fcgr2b NZW allele fails to be upregulated in germinal center B cells and is associated with increased IgG production.
Genes and immunity 2007;8(7):604-12.
2007: Boris Alabyev; Ziaur S M Rahman; Tim Manser
Quantitatively reduced participation of anti-nuclear antigen B cells that down-regulate B cell receptor during primary development in the germinal center/memory B cell response to foreign antigen.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5623-34.
2007: Xiaohe Liu; Lawrence J Wysocki; Tim Manser
Autoantigen-B cell antigen receptor interactions that regulate expression of B cell antigen receptor Loci.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):5035-47.
2007: Ziaur S M Rahman; Boris Alabyev; Tim Manser
FcgammaRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):897-907.
2006: Hongxia Z Imtiyaz; Stephen Rosenberg; Yuhang Zhang; Ziaur S M Rahman; Ying-Ju Hou; Tim Manser; Jianke Zhang
The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6852-61.
2005: Lynn Heltemes-Harris; Xiaohe Liu; Tim Manser
An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion.
International immunology 2005;17(11):1447-61.
2005: Ziaur S M Rahman; Tim Manser
Failed up-regulation of the inhibitory IgG Fc receptor Fc gamma RIIB on germinal center B cells in autoimmune-prone mice is not associated with deletion polymorphisms in the promoter region of the Fc gamma RIIB gene.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1440-9.
2005: Xiaohe Liu; Tim Manser
Antinuclear antigen B cells that down-regulate surface B cell receptor during development to mature, follicular phenotype do not display features of anergy in vitro.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4505-15.
2004: Ziaur S M Rahman; Tim Manser
B cells expressing Bcl-2 and a signaling-impaired BAFF-specific receptor fail to mature and are deficient in the formation of lymphoid follicles and germinal centers.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6179-88.
2004: Tatiana Mareeva; Tatiana Lebedeva; Nadja Anikeeva; Tim Manser; Yuri Sykulev
Antibody specific for the peptide.major histocompatibility complex. Is it T cell receptor-like?
The Journal of biological chemistry 2004;279(43):44243-9.
2004: Tim Manser
Textbook germinal centers?
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3369-75.
2004: Lynn Heltemes-Harris; Xiaohe Liu; Tim Manser
Progressive surface B cell antigen receptor down-regulation accompanies efficient development of antinuclear antigen B cells to mature, follicular phenotype.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):823-33.
2003: Ziaur S M Rahman; Sambasiva P Rao; Susan L Kalled; Tim Manser
Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice.
The Journal of experimental medicine 2003;198(8):1157-69.
2002: Boris Alabyev; Tim Manser
Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3819-24.
2002: Evangelia Notidis; Lynn M Heltemes; Tim Manser
Dominant, hierarchical induction of peripheral tolerance during foreign antigen-driven B cell development.
Immunity 2002;17(3):317-27.
2002: Sambasiva P Rao; Kalpit A Vora; Tim Manser
Differential expression of the inhibitory IgG Fc receptor FcgammaRIIB on germinal center cells: implications for selection of high-affinity B cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):1859-68.
2002: Lynn M Heltemes; Tim Manser
Level of B cell antigen receptor surface expression influences both positive and negative selection of B cells during primary development.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1283-92.
2001: VM Lentz; Tim Manser
Cutting edge: germinal centers can be induced in the absence of T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):15-20.
2001: KM Tumas-Brundage; Evangelia Notidis; Lynn M Heltemes; Xianghua Zhang; Lawrence J Wysocki; Tim Manser
Predominance of a novel splenic B cell population in mice expressing a transgene that encodes multireactive antibodies: support for additional heterogeneity of the B cell compartment.
International immunology 2001;13(4):475-84.
2001: Kalpit A Vora; VM Lentz; W Monsell; Sambasiva P Rao; Richard V Mettus; A Toscani; E Premkumar Reddy; Tim Manser
The T cell-dependent B cell immune response and germinal center reaction are intact in A-myb-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3226-30.
2001: Evangelia Notidis; S Hande; Tim Manser
Enforced expression of Bcl-2 selectively perturbs negative selection of dual reactive antibodies.
Developmental immunology 2001;8(3-4):223-34.
2001: Robert J Benschop; Katja Aviszus; Xianghua Zhang; Tim Manser; John C Cambier; Lawrence J Wysocki
Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive.
Immunity 2001;14(1):33-43.
2000: VM Lentz; Tim Manser
Self-limiting systemic autoimmune disease during reconstitution of T cell-deficient mice with syngeneic T cells: support for a multifaceted role of T cells in the maintenance of peripheral B cell tolerance.
International immunology 2000;12(11):1483-97.
2000: D Qin; Jiuhua Wu; Kalpit A Vora; JV Ravetch; Andras K Szakal; Tim Manser; John G Tew
Fc gamma receptor IIB on follicular dendritic cells regulates the B cell recall response.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6268-75.
1999: Kalpit A Vora; KM Tumas-Brundage; Tim Manser
Contrasting the in situ behavior of a memory B cell clone during primary and secondary immune responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4315-27.
1999: Kalpit A Vora; KM Tumas-Brundage; VM Lentz; A Cranston; Richard Fishel; Tim Manser
Severe attenuation of the B cell immune response in Msh2-deficient mice.
The Journal of experimental medicine 1999;189(3):471-82.
1998: C C Huang; P Y Ts'ao; Tim Manser
T-cell receptor repertoires utilized in response to linear peptides representing an immunodominant MHC class II restricted T-cell epitope are far more diverse than that utilized in response to the same epitope in the nominal antigen.
Molecular immunology 1998;35(5):279-91.
1998: Tim Manser; KM Tumas-Brundage; L P Casson; A M Giusti; S Hande; Evangelia Notidis; Kalpit A Vora
The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment.
Immunological reviews 1998;162():183-96.
1998: S Hande; Evangelia Notidis; Tim Manser
Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development.
Immunity 1998;8(2):189-98.
1998: Kalpit A Vora; KM Tumas-Brundage; Tim Manser
A periarteriolar lymphoid sheath-associated B cell focus response is not observed during the development of the anti-arsonate germinal center reaction.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):728-33.
1998: Kalpit A Vora; JV Ravetch; Tim Manser
Insights into the mechanisms of antibody-affinity maturation and the generation of the memory B-cell compartment using genetically altered mice.
Developmental immunology 1998;6(3-4):305-16.
1997: S Hande; Tim Manser
Single amino acid substitutions in V(H) CDR2 are sufficient to generate or enhance the specificity of two forms of an anti-arsonate antibody variable region for DNA.
Molecular immunology 1997;34(18):1281-90.
1997: Kalpit A Vora; JV Ravetch; Tim Manser
Amplified follicular immune complex deposition in mice lacking the Fc receptor gamma-chain does not alter maturation of the B cell response.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2116-24.
1997: KM Tumas-Brundage; Kalpit A Vora; Tim Manser
Evaluation of the role of the 3'alpha heavy chain enhancer [3'alpha E(hs1,2)] in Vh gene somatic hypermutation.
Molecular immunology 1997;34(5):367-78.
1997: KM Tumas-Brundage; Tim Manser
The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.
The Journal of experimental medicine 1997;185(2):239-50.
1996: KM Tumas-Brundage; Kalpit A Vora; A M Giusti; Tim Manser
Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches.
Seminars in immunology 1996;8(3):141-50.
1996: S Hande; B A Jacobson; Tim Manser
A recurrent clonotype in the spontaneous anti-IgG2a rheumatoid factor response of lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(5):1856-64.
1995: L P Casson; Tim Manser
Evaluation of loss and change of specificity resulting from random mutagenesis of an antibody VH region.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5647-54.
1995: L P Casson; Tim Manser
Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen.
The Journal of experimental medicine 1995;182(3):743-50.
1995: Kalpit A Vora; Tim Manser
Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.
The Journal of experimental medicine 1995;181(1):271-81.
1994: A M Giusti; Tim Manser
Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.
The Journal of experimental medicine 1994;179(1):235-48.
1993: E Trannoy; Tim Manser; M D Cole; Michael Daley
Monoclonal c-myc transformed macrophage cell lines. I. Heterogeneity in ability to process and present antigen.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(6):3042-56.
1993: A M Giusti; Tim Manser
Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.
The Journal of experimental medicine 1993;177(3):797-809.
1992: A M Giusti; R Coffee; Tim Manser
Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10321-5.
1991: P Soloway; S Fish; H Passmore; M Gefter; R Coffee; Tim Manser
Regulation of the immune response to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype.
The Journal of experimental medicine 1991;174(4):847-58.
1991: S Fish; M Fleming; Jacqueline Sharon; Tim Manser
Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response.
The Journal of experimental medicine 1991;173(3):665-72.
1990: Tim Manser
The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?
Immunology today 1990;11(9):305-8.
1990: Tim Manser
Limits on heavy chain junctional diversity contribute to the recurrence of an antibody variable region.
Molecular immunology 1990;27(6):503-11.
1990: Tim Manser
The intraclonal diversity and control of antibody isotype switch recombination.
International immunology 1990;2(9):893-902.
1989: Tim Manser
Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.
The Journal of experimental medicine 1989;170(4):1211-30.
1989: S Fish; E Zenowich; M Fleming; Tim Manser
Molecular analysis of original antigenic sin. I. Clonal selection, somatic mutation, and isotype switching during a memory B cell response.
The Journal of experimental medicine 1989;170(4):1191-209.
1987: Tim Manser; Behnaz Parhami-Seren; Michael N Margolies; M L Gefter
Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate. By-products of an antigen-driven immune response?
The Journal of experimental medicine 1987;166(5):1456-63.
1987: S Fish; Tim Manser
Influence of the macromolecular form of a B cell epitope on the expression of antibody variable and constant region structure.
The Journal of experimental medicine 1987;166(3):711-24.
1987: Tim Manser; Lawrence J Wysocki; Michael N Margolies; M L Gefter
Evolution of antibody variable region structure during the immune response.
Immunological reviews 1987;96():141-62.
1986: Lawrence J Wysocki; Tim Manser; T Gridley; M L Gefter
Molecular limitations on variable-gene junctional diversity.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(12):3699-701.
1986: Yaakov Naparstek; J André-Schwartz; Tim Manser; Lawrence J Wysocki; L Breitman; B D Stollar; M Gefter; Robert S Schwartz
A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.
The Journal of experimental medicine 1986;164(2):614-26.
1986: Jacqueline Sharon; M L Gefter; Tim Manser; Mark Ptashne
Site-directed mutagenesis of an invariant amino acid residue at the variable-diversity segments junction of an antibody.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2628-31.
1985: C Victor-Kobrin; Tim Manser; T M Moran; T Imanishi-Kari; M Gefter; C A Bona
Shared idiotopes among antibodies encoded by heavy-chain variable region (VH) gene members of the J558 VH family as basis for cross-reactive regulation of clones with different antigen specificity.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(22):7696-700.
1984: Jacqueline Sharon; M L Gefter; Tim Manser; S L Morrison; V T Oi; Mark Ptashne
Expression of a VHC kappa chimaeric protein in mouse myeloma cells.
Nature 1984;309(5966):364-7.
1984: M Nakamura; Tim Manser; G D Pearson; Michael Daley; M L Gefter
Effect of IFN-gamma on the immune response in vivo and on gene expression in vitro.
Nature 1984;307(5949):381-2.