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Daniel Mansuy

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Patrick M Dansette; Assia Hessani; Dan Levent; Gildas Bertho; Daniel Mansuy
Thiolactone sulfoxides as new reactive metabolites acting as bis-electrophiles: implication in clopidogrel and prasugrel bioactivation.
Patrick M Dansette; Justine Debernardi; Gildas Bertho; Julien Rosi; Daniel Mansuy
Metabolic activation of prasugrel: nature of the two competitive pathways resulting in the opening of its thiophene ring.
Patrick M Dansette; Gildas Bertho; Julien Rosi; Daniel Mansuy
Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer.

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2013: Patrick M Dansette; Assia Hessani; Dan Levent; Gildas Bertho; Daniel Mansuy
Thiolactone sulfoxides as new reactive metabolites acting as bis-electrophiles: implication in clopidogrel and prasugrel bioactivation.
Chemical research in toxicology 2013;26(5):794-802.
2012: Patrick M Dansette; Justine Debernardi; Gildas Bertho; Julien Rosi; Daniel Mansuy
Metabolic activation of prasugrel: nature of the two competitive pathways resulting in the opening of its thiophene ring.
Chemical research in toxicology 2012;25(5):1058-65.
2012: Patrick M Dansette; Gildas Bertho; Julien Rosi; Daniel Mansuy
Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer.
Chemical research in toxicology 2012;25(2):348-56.
2012: Isabelle Salard-Arnaud; Dennis Stuehr; Jean-Luc Boucher; Daniel Mansuy
Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases.
Journal of inorganic biochemistry 2012;106(1):164-71.
2011: Patrick M Dansette; Gildas Bertho; Julien Rosi; Daniel Mansuy
Paraoxonase-1 and clopidogrel efficacy.
Nature medicine 2011;17(9):1040-1; author reply 1042-4.
2011: Christophe Decroos; Thierry Prangé; Daniel Mansuy; Jean-Luc Boucher; Yun Li
Unprecedented ipso aromatic nucleophilic substitution upon oxidative decarboxylation of tris(p-carboxyltetrathiaaryl)methyl (TAM) radicals: a new access to diversely substituted TAM radicals.
Chemical communications (Cambridge, England) 2011;47(16):4805-7.
2011: Murielle Lombard; Isabelle Salard; Marie-Agnès Sari; Daniel Mansuy; Didier Buisson
A new cytochrome P450 belonging to the 107L subfamily is responsible for the efficient hydroxylation of the drug terfenadine by Streptomyces platensis.
Archives of biochemistry and biophysics 2011;508(1):54-63.
2011: Daniel Mansuy; Patrick M Dansette
Sulfenic acids as reactive intermediates in xenobiotic metabolism.
Archives of biochemistry and biophysics 2011;507(1):174-85.
2010: Christophe Decroos; Yun Li; Asma Soltani; Yves-Michel Frapart; Daniel Mansuy; Jean-Luc Boucher
Oxidative decarboxylation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes by peroxidases and related hemeproteins: intermediate formation and characterization of the corresponding cations.
Archives of biochemistry and biophysics 2010;502(1):74-80.
2010: Nicolas Bézière; Yves-Michel Frapart; Antal Rockenbauer; Jean-Luc Boucher; Daniel Mansuy; Fabienne Peyrot
Metabolic stability of superoxide and hydroxyl radical adducts of a cyclic nitrone toward rat liver microsomes and cytosol: A stopped-flow ESR spectroscopy study.
Free radical biology & medicine 2010;49(3):437-46.
2010: Patrick M Dansette; Stéphanie Thébault; Gildas Bertho; Daniel Mansuy
Formation and fate of a sulfenic acid intermediate in the metabolic activation of the antithrombotic prodrug prasugrel.
Chemical research in toxicology 2010;23(7):1268-74.
2009: Christophe Decroos; Yun Li; Gildas Bertho; Yves-Michel Frapart; Daniel Mansuy; Jean-Luc Boucher
Oxidative and reductive metabolism of tris(p-carboxyltetrathiaaryl)methyl radicals by liver microsomes.
Chemical research in toxicology 2009;22(7):1342-50.
2009: Christophe Decroos; Yun Li; Gildas Bertho; Yves-Michel Frapart; Daniel Mansuy; Jean-Luc Boucher
Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2*-.
Chemical communications (Cambridge, England) 2009;(11):1416-8.
2009: Patrick M Dansette; Julie Libraire; Gildas Bertho; Daniel Mansuy
Metabolic oxidative cleavage of thioesters: evidence for the formation of sulfenic acid intermediates in the bioactivation of the antithrombotic prodrugs ticlopidine and clopidogrel.
Chemical research in toxicology 2009;22(2):369-73.
2008: Betty Cottyn; Francine Acher; Booma Ramassamy; Luke Alvey; Michel Lepoivre; Yves-Michel Frapart; Dennis J Stuehr; Daniel Mansuy; Jean-Luc Boucher; Dominique Vichard
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.
Bioorganic & medicinal chemistry 2008;16(11):5962-73.
2008: Alexia Chandor; Sylvie Dijols; Booma Ramassamy; Yves-Michel Frapart; Daniel Mansuy; Dennis J Stuehr; Nuala Helsby; Jean-Luc Boucher
Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases.
Chemical research in toxicology 2008;21(4):836-43.
2007: Pierre Lafite; François André; Darryl C Zeldin; Patrick M Dansette; Daniel Mansuy
Unusual regioselectivity and active site topology of human cytochrome P450 2J2.
Biochemistry 2007;46(36):10237-47.
2007: Pierre Lafite; Sylvie Dijols; Darryl C Zeldin; Patrick M Dansette; Daniel Mansuy
Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.
Archives of biochemistry and biophysics 2007;464(2):155-68.
2006: Isabelle Salard; Emilie Mercey; Eleni A Rekka; Jean-Luc Boucher; Pierre Nioche; Ivan Mikula; Pavel Martasek; C.S. Raman; Daniel Mansuy
Analogies and surprising differences between recombinant nitric oxide synthase-like proteins from Staphylococcus aureus and Bacillus anthracis in their interactions with l-arginine analogs and iron ligands.
Journal of inorganic biochemistry 2006;100(12):2024-33.
2006: Pierre Lafite; Sylvie Dijols; Didier Buisson; Anne-Christine Macherey; Darryl C Zeldin; Patrick M Dansette; Daniel Mansuy
Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.
Bioorganic & medicinal chemistry letters 2006;16(10):2777-80.
2006: Magali Moreau; Jean-Luc Boucher; Tony A Mattioli; Dennis J Stuehr; Daniel Mansuy; Jérôme Santolini
Differential effects of alkyl- and arylguanidines on the stability and reactivity of inducible NOS heme-dioxygen complexes.
Biochemistry 2006;45(12):3988-99.
2006: David Lefèvre-Groboillot; Jean-Luc Boucher; Daniel Mansuy; Dennis J Stuehr
Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates.
The FEBS journal 2006;273(1):180-91.
2005: Chantal Capeillere-Blandin; Delphine Mathieu; Daniel Mansuy
Reduction of ferric haemoproteins by tetrahydropterins: a kinetic study.
The Biochemical journal 2005;392(Pt 3):583-7.
2005: Patrick M Dansette; Gildas Bertho; Daniel Mansuy
First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives.
Biochemical and biophysical research communications 2005;338(1):450-5.
2005: Daniel Mansuy
[Nobel Prize in Chemistry, 2005. Yves Chauvin, Robert H. Grubbs and Richard R. Schrock. Metathesis and catalysis honored].
Médecine sciences : M/S 2005;21(11):995-6.
2005: David Lefèvre-Groboillot; Jean-Luc Boucher; Dennis J Stuehr; Daniel Mansuy
Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO.
The FEBS journal 2005;272(12):3172-83.
2005: Olivier Busnel; François Carreaux; Bertrand Carboni; Stéphanie Pethe; Sandrine Vadon-Le Goff; Daniel Mansuy; Jean-Luc Boucher
Synthesis and evaluation of new omega-borono-alpha-amino acids as rat liver arginase inhibitors.
Bioorganic & medicinal chemistry 2005;13(7):2373-9.
2004: Armelle Melet; Cristina Marques-Soares; Guillaume A Schoch; Anne-Christine Macherey; Maryse Jaouen; Patrick M Dansette; Marie-Agnès Sari; Eric F Johnson; Daniel Mansuy
Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants.
Biochemistry 2004;43(49):15379-92.
2004: Daniel Mansuy; Jean-Luc Boucher
Alternative nitric oxide-producing substrates for NO synthases.
Free radical biology & medicine 2004;37(8):1105-21.
2004: Damien Gerald; Edurne Berra; Yves-Michel Frapart; Denise A Chan; Amato J Giaccia; Daniel Mansuy; Jacques Pouysségur; Moshe Yaniv; Fatima Mechta-Grigoriou
JunD reduces tumor angiogenesis by protecting cells from oxidative stress.
Cell 2004;118(6):781-94.
2004: Evis Cama Hursever; Stéphanie Pethe; Jean-Luc Boucher; Shoufa Han; Frances A Emig; David E Ash; Ronald E Viola; Daniel Mansuy; David W Christianson
Inhibitor coordination interactions in the binuclear manganese cluster of arginase.
Biochemistry 2004;43(28):8987-99.
2004: Magali Moreau; Hiroto Takahashi; Marie-Agnes Sari; Jean-Luc Boucher; Ikuko Sagami; Toru Shimizu; Daniel Mansuy
Importance of valine 567 in substrate recognition and oxidation by neuronal nitric oxide synthase.
Journal of inorganic biochemistry 2004;98(7):1200-9.
2004: Delphine Mathieu; Yves-Michel Frapart; Jean François Bartoli; Jean-Luc Boucher; Pierrette Battioni; Daniel Mansuy
Very general formation of tetrahydropterin cation radicals during reaction of iron porphyrins with tetrahydropterins: model for the corresponding NO-synthase reaction.
Chemical communications (Cambridge, England) 2004;(1):54-5.
2003: Kjetil Ask; Sylvie Dijols; C Giroud; L Casse; Yves-Michel Frapart; Marie-Agnès Sari; K-S Kim; Dennis J Stuehr; Daniel Mansuy; Philippe Camus; Jean-Luc Boucher
Reduction of nilutamide by NO synthases: implications for the adverse effects of this nitroaromatic antiandrogen drug.
Chemical research in toxicology 2003;16(12):1547-54.
2003: Sandra L Pfister; Nancy Spitzbarth; Darryl C Zeldin; Pierre Lafite; Daniel Mansuy; William B Campbell
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
Archives of biochemistry and biophysics 2003;420(1):142-52.
2003: Julie M Stevens; Maya Belghazi; Maryse Jaouen; Didier Bonnet; Jean-Marie Schmitter; Daniel Mansuy; Marie-Agnès Sari; Isabelle Artaud
Post-translational modification of Rhodococcus R312 and Comamonas NI1 nitrile hydratases.
Journal of mass spectrometry : JMS 2003;38(9):955-61.
2003: Michael R Wester; Eric F Johnson; Cristina Marques-Soares; Sylvie Dijols; Patrick M Dansette; Daniel Mansuy; C David Stout
Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding.
Biochemistry 2003;42(31):9335-45.
2003: Michael R Wester; Eric F Johnson; Cristina Marques-Soares; Patrick M Dansette; Daniel Mansuy; C David Stout
Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes.
Biochemistry 2003;42(21):6370-9.
2003: Cristina Marques-Soares; Sylvie Dijols; Anne-Christine Macherey; Michael R Wester; Eric F Johnson; Patrick M Dansette; Daniel Mansuy
Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes.
Biochemistry 2003;42(21):6363-9.
2003: Julie M Stevens; Narsing Rao Saroja; Maryse Jaouen; Maya Belghazi; Jean-Marie Schmitter; Daniel Mansuy; Isabelle Artaud; Marie-Agnès Sari
Chaperone-assisted expression, purification, and characterization of recombinant nitrile hydratase NI1 from Comamonas testosteroni.
Protein expression and purification 2003;29(1):70-6.
2003: David Lefèvre-Groboillot; Yves-Michel Frapart; Alain Desbois; Jean-Luc Zimmermann; Jean-Luc Boucher; Antonius C F Gorren; Bernd Mayer; Dennis J Stuehr; Daniel Mansuy
Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode.
Biochemistry 2003;42(13):3858-67.
2003: Rémy Ricoux; Jean-Luc Boucher; Dominique Mandon; Yves-Michel Frapart; Yann Henry; Daniel Mansuy; Jean-Pierre Mahy
Microperoxidase 8 catalysed nitrogen oxides formation from oxidation of N-hydroxyguanidines by hydrogen peroxide.
European journal of biochemistry / FEBS 2003;270(1):47-55.
2003: Armelle Melet; Nadine Assrir; Pascale Jean; Maria Pilar Lopez-Garcia; Cristina Marques-Soares; Maryse Jaouen; Patrick M Dansette; Marie-Agnès Sari; Daniel Mansuy
Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid.
Archives of biochemistry and biophysics 2003;409(1):80-91.
2002: Kathleen M Barkigia; Magali Palacio; Yu Sun; Marc Nogues; Mark W Renner; François Varret; Pierrette Battioni; Daniel Mansuy; Jack Fajer
Air-stable, electron-deficient Fe(II) catalytic porphyrins. Characterization and molecular structures of rare high spin Fe(II) hexacoordinated porphyrins.
Inorganic chemistry 2002;41(22):5647-9.
2002: Alexander Treiber; Patrick M Dansette; Daniel Mansuy
Mechanism of the aromatic hydroxylation of thiophene by acid-catalyzed peracid oxidation.
The Journal of organic chemistry 2002;67(21):7261-6.
2002: Daniel Mansuy; Jean-Luc Boucher
Oxidation of N-hydroxyguanidines by cytochromes P450 and NO-synthases and formation of nitric oxide.
Drug metabolism reviews 2002;34(3):593-606.
2002: Sylvie Dijols; Jean-Luc Boucher; Michel Lepoivre; David Lefevre-Groboillot; Magali Moreau; Yves-Michel Frapart; Eleni A Rekka; Abigail L Meade; Dennis J Stuehr; Daniel Mansuy
First non-alpha-amino acid guanidines acting as efficient NO precursors upon oxidation by NO-synthase II or activated mouse macrophages.
Biochemistry 2002;41(30):9286-92.
2002: Kathleen M Barkigia; Pierrette Battioni; Vanessa Riou; Daniel Mansuy; Jack Fajer
Supramolecular self-assembly of a fluorinated Zn porphyrin. Molecular structure of a two-dimensional network of amine-functionalized, hexacoordinated Zn porphyrins.
Chemical communications (Cambridge, England) 2002;(9):956-7.
2002: Axelle Renodon-Cornière; Sylvie Dijols; Céline Perollier; David Lefevre-Groboillot; Jean-Luc Boucher; Roger Attias; Marie-Agnès Sari; Dennis J Stuehr; Daniel Mansuy
N-Aryl N'-hydroxyguanidines, a new class of NO-donors after selective oxidation by nitric oxide synthases: structure-activity relationship.
Journal of medicinal chemistry 2002;45(4):944-54.
2002: Stéphanie Pethe; Jean-Luc Boucher; Daniel Mansuy
Interaction of anions with rat liver arginase: specific inhibitory effects of fluoride.
Journal of inorganic biochemistry 2002;88(3-4):397-402.
2002: Solange de Lauzon; Daniel Mansuy; Jean-Pierre Mahy
Coordination chemistry of iron(III)-porphyrin-antibody complexes.
European journal of biochemistry / FEBS 2002;269(2):470-80.
2001: NT Ha-Duong; Sylvie Dijols; Cristina Marques-Soares; C Minoletti; Patrick M Dansette; Daniel Mansuy
Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily.
Journal of medicinal chemistry 2001;44(22):3622-31.
2001: NT Ha-Duong; Cristina Marques-Soares; Sylvie Dijols; Marie-Agnès Sari; Patrick M Dansette; Daniel Mansuy
Interaction of new sulfaphenazole derivatives with human liver cytochrome p450 2Cs: structural determinants required for selective recognition by CYP 2C9 and for inhibition of human CYP 2Cs.
Archives of biochemistry and biophysics 2001;394(2):189-200.
2001: NT Ha-Duong; Sylvie Dijols; Anne-Christine Macherey; J A Goldstein; Patrick M Dansette; Daniel Mansuy
Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19.
Biochemistry 2001;40(40):12112-22.
2001: Sylvie Dijols; C Perollier; David Lefevre-Groboillot; Stéphanie Pethe; Roger Attias; Jean-Luc Boucher; Dennis J Stuehr; Daniel Mansuy
Oxidation of N(omega)-hydroxyarginine analogues by NO-synthase: the simple, non amino acid N-butyl N'-hydroxyguanidine is almost as efficient an NO precursor as N(omega)-hydroxyarginine.
Journal of medicinal chemistry 2001;44(20):3199-202.
2001: J F Bartoli; K Le Barch; M Palacio; Pierrette Battioni; Daniel Mansuy
Iron polynitroporphyrins bearing up to eight beta-nitro groups as interesting new catalysts for H2O2-dependent hydrocarbon oxidation: unusual regioselectivity in hydroxylation of alkoxybenzenes.
Chemical communications (Cambridge, England) 2001;(18):1718-9.
2001: David Lefevre-Groboillot; Sylvie Dijols; Jean-Luc Boucher; Jean-Pierre Mahy; Rémy Ricoux; A Desbois; J L Zimmermann; Daniel Mansuy
N-hydroxyguanidines as new heme ligands: UV-visible, EPR, and resonance Raman studies of the interaction of various compounds bearing a C=NOH function with microperoxidase-8.
Biochemistry 2001;40(33):9909-17.
2001: Didier Bonnet; Julie M Stevens; R A de Sousa; Marie-Agnès Sari; Daniel Mansuy; Isabelle Artaud
New inhibitors of iron-containing nitrile hydratases.
Journal of biochemistry 2001;130(2):227-33.
2001: Rémy Ricoux; Jean-Luc Boucher; Daniel Mansuy; Jean-Pierre Mahy
Microperoxidase 8 catalyzed nitration of phenol by nitrogen dioxide radicals.
European journal of biochemistry / FEBS 2001;268(13):3783-8.
2001: S Vadon-Le Goff; Marcel Delaforge; Jean-Luc Boucher; Miroslav Janosik; Jan P Kraus; Daniel Mansuy
Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes.
Biochemical and biophysical research communications 2001;283(2):487-92.
2001: Mathieu Rat; R A de Sousa; Jacqueline Vaissermann; P Leduc; Daniel Mansuy; Isabelle Artaud
Clean oxidation of thiolates to sulfinates in a four-coordinate CoIII complex with a mixed carboxamido N-thiolato S donor set: relevance to nitrile hydratase.
Journal of inorganic biochemistry 2001;84(3-4):207-13.
2001: J David Cox; Evis Cama Hursever; Diana M Colleluori; Stéphanie Pethe; Jean-Luc Boucher; Daniel Mansuy; David E Ash; David W Christianson
Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase.
Biochemistry 2001;40(9):2689-701.
2001: C Moali; Jean-Luc Boucher; A Renodon-Corniere; Dennis J Stuehr; Daniel Mansuy
Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity.
Chemical research in toxicology 2001;14(2):202-10.
2001: Rémy Ricoux; Jean-Luc Boucher; Daniel Mansuy; Jean-Pierre Mahy
Microperoxidase 8 (mp8) as a convenient model for hemoproteins: formation and characterisation of new iron(II)-nitrosoalkane complexes of biological relevance.
Advances in experimental medicine and biology 2001;500():149-52.
2001: NT Ha-Duong; Sylvie Dijols; Anne-Christine Macherey; Patrick M Dansette; Daniel Mansuy
Inhibition by ticlopidine and its derivatives of human liver cytochrome p450. Mechanism-based inactivation of CYP 2C19 by ticlopidine.
Advances in experimental medicine and biology 2001;500():145-8.
2001: Maya Belghazi; Pascale Jean; Sonia Poli; Jean-Marie Schmitter; Daniel Mansuy; Patrick M Dansette
Use of isotopes and LC-MS-ESI-TOF for mechanistic studies of tienilic acid metabolic activation.
Advances in experimental medicine and biology 2001;500():139-44.
2000: Rémy Ricoux; Jean-Luc Boucher; Daniel Mansuy; Jean-Pierre Mahy
Formation of iron(II)-nitrosoalkane complexes: a new activity of microperoxidase 8.
Biochemical and biophysical research communications 2000;278(1):217-23.
2000: C Moali; M Brollo; J Custot; Marie-Agnès Sari; Jean-Luc Boucher; Dennis J Stuehr; Daniel Mansuy
Recognition of alpha-amino acids bearing various C=NOH functions by nitric oxide synthase and arginase involves very different structural determinants.
Biochemistry 2000;39(28):8208-18.
2000: S Chatel; Mathieu Rat; Sylvie Dijols; P Leduc; Jean-Pierre Tuchagues; Daniel Mansuy; Isabelle Artaud
Toward model complexes of Co-containing nitrile hydratases: synthesis, complete characterization and reactivity toward ligands such as CN- and NO of the first square planar CoIII complex with two different carboxamido nitrogens and two thiolato sulfur donors.
Journal of inorganic biochemistry 2000;80(3-4):239-46.
1999: Jean-Pierre Tenu; Michel Lepoivre; C Moali; M Brollo; Daniel Mansuy; Jean-Luc Boucher
Effects of the new arginase inhibitor N(omega)-hydroxy-nor-L-arginine on NO synthase activity in murine macrophages.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 1999;3(6):427-38.
1999: A Mancy; M Antignac; C Minoletti; Sylvie Dijols; V Mouries; N T Duong; Pierrette Battioni; Patrick M Dansette; Daniel Mansuy
Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs.
Biochemistry 1999;38(43):14264-70.
1999: C Minoletti; Sylvie Dijols; Patrick M Dansette; Daniel Mansuy
Comparison of the substrate specificities of human liver cytochrome P450s 2C9 and 2C18: application to the design of a specific substrate of CYP 2C18.
Biochemistry 1999;38(24):7828-36.
1999: Axelle Renodon-Cornière; Jean-Luc Boucher; Sylvie Dijols; Dennis J Stuehr; Daniel Mansuy
Efficient formation of nitric oxide from selective oxidation of N-aryl N'-hydroxyguanidines by inducible nitric oxide synthase.
Biochemistry 1999;38(15):4663-8.
1999: Eric Bonierbale; P Valadon; C Pons; B Desfosses; Patrick M Dansette; Daniel Mansuy
Opposite behaviors of reactive metabolites of tienilic acid and its isomer toward liver proteins: use of specific anti-tienilic acid-protein adduct antibodies and the possible relationship with different hepatotoxic effects of the two compounds.
Chemical research in toxicology 1999;12(3):286-96.
1999: Solange de Lauzon; B Desfosses; Daniel Mansuy; Jean-Pierre Mahy
Studies of the reactivity of artificial peroxidase-like hemoproteins based on antibodies elicited against a specifically designed ortho-carboxy substituted tetraarylporphyrin.
FEBS letters 1999;443(2):229-34.
1998: A Jousserandot; Jean-Luc Boucher; Y Henry; B Niklaus; B Clement; Daniel Mansuy
Microsomal cytochrome P450 dependent oxidation of N-hydroxyguanidines, amidoximes, and ketoximes: mechanism of the oxidative cleavage of their C=N(OH) bond with formation of nitrogen oxides.
Biochemistry 1998;37(49):17179-91.
1998: Patrick M Dansette; Eric Bonierbale; C Minoletti; PH Beaune; D Pessayre; Daniel Mansuy
Drug-induced immunotoxicity.
European journal of drug metabolism and pharmacokinetics 1998;23(4):443-51.
1998: Jean-Pierre Mahy; B Desfosses; Solange de Lauzon; R Quilez; B Desfosses; L Lion; Daniel Mansuy
Hemoabzymes. Different strategies for obtaining artificial hemoproteins based on antibodies.
Applied biochemistry and biotechnology 1998;75(1):103-27.
1998: Solange de Lauzon; R Quilez; L Lion; B Desfosses; B Desfosses; I Lee; Marie-Agnès Sari; S J Benkovic; Daniel Mansuy; Jean-Pierre Mahy
Active site topology of artificial peroxidase-like hemoproteins based on antibodies constructed from a specifically designed ortho-carboxy-substituted tetraarylporphyrin.
European journal of biochemistry / FEBS 1998;257(1):121-30.
1998: Marie-Agnès Sari; C Moali; Jean-Luc Boucher; Maryse Jaouen; Daniel Mansuy
Detection of a nitric oxide synthase possibly involved in the regulation of the Rhodococcus sp R312 nitrile hydratase.
Biochemical and biophysical research communications 1998;250(2):364-8.
1998: C Moali; Jean-Luc Boucher; Marie-Agnès Sari; Dennis J Stuehr; Daniel Mansuy
Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine.
Biochemistry 1998;37(29):10453-60.
1998: A Renodon; Jean-Luc Boucher; C Wu; R Gachhui; Marie-Agnès Sari; Daniel Mansuy; Dennis J Stuehr
Formation of nitric oxide synthase-iron(II) nitrosoalkane complexes: severe restriction of access to the iron(II) site in the presence of tetrahydrobiopterin.
Biochemistry 1998;37(18):6367-74.
1997: Robert R Crichton; J A Soruco; F Roland; M A Michaux; Bernard Gallois; Gilles Précigoux; Jean-Pierre Mahy; Daniel Mansuy
Remarkable ability of horse spleen apoferritin to demetallate hemin and to metallate protoporphyrin IX as a function of pH.
Biochemistry 1997;36(49):15049-54.
1997: A Renodon; Jean-Luc Boucher; Marie-Agnès Sari; Marcel Delaforge; Jamal Ouazzani; Daniel Mansuy
Strong inhibition of neuronal nitric oxide synthase by the calmodulin antagonist and anti-estrogen drug tamoxifen.
Biochemical pharmacology 1997;54(10):1109-14.
1997: Sonia Poli; Roger Attias; Patrick M Dansette; Daniel Mansuy
The substrate binding site of human liver cytochrome P450 2C9: an NMR study.
Biochemistry 1997;36(42):12672-82.
1997: Pascale Jean; Joel Pothier; Patrick M Dansette; Daniel Mansuy; Alain Viari
Automated multiple analysis of protein structures: application to homology modeling of cytochromes P450.
Proteins 1997;28(3):388-404.
1997: Didier Bonnet; Isabelle Artaud; C Moali; D Pétré; Daniel Mansuy
Highly efficient control of iron-containing nitrile hydratases by stoichiometric amounts of nitric oxide and light.
FEBS letters 1997;409(2):216-20.
1997: A Renodon; Jean-Luc Boucher; Marie-Agnès Sari; Marcel Delaforge; Jamal Ouazzani; Daniel Mansuy
Bromocriptine is a strong inhibitor of brain nitric oxide synthase: possible consequences for the origin of its therapeutic effects.
FEBS letters 1997;406(1-2):33-6.
1997: Daniel Mansuy
Molecular structure and hepatotoxicity: compared data about two closely related thiophene compounds.
Journal of hepatology 1997;26 Suppl 2():22-5.
1996: A Mancy; Sylvie Dijols; Sonia Poli; P Guengerich; Daniel Mansuy
Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: molecular origin of the specific inhibitory effects of sulfaphenazole on CYP 2C9 and consequences for the substrate binding site topology of CYP 2C9.
Biochemistry 1996;35(50):16205-12.
1996: P Valadon; Patrick M Dansette; Jean-Pierre Girault; C Amar; Daniel Mansuy
Thiophene sulfoxides as reactive metabolites: formation upon microsomal oxidation of a 3-aroylthiophene and fate in the presence of nucleophiles in vitro and in vivo.
Chemical research in toxicology 1996;9(8):1403-13.
1996: P Jean; P Lopez-Garcia; Patrick M Dansette; Daniel Mansuy; J L Goldstein
Oxidation of tienilic acid by human yeast-expressed cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this drug is a mechanism-based inhibitor specific for cytochrome P-450 2C9.
European journal of biochemistry / FEBS 1996;241(3):797-804.
1996: J P Renaud; Dmitri Davydov; K P Heirwegh; Daniel Mansuy; Gaston Hui Bon Hoa
Thermodynamic studies of substrate binding and spin transitions in human cytochrome P-450 3A4 expressed in yeast microsomes.
The Biochemical journal 1996;319 ( Pt 3)():675-81.
1996: R Quilez; Solange de Lauzon; B Desfosses; Daniel Mansuy; Jean-Pierre Mahy
Artificial peroxidase-like hemoproteins based on antibodies constructed from a specifically designed ortho-carboxy substituted tetraarylporphyrin hapten and exhibiting a high affinity for iron-porphyrins.
FEBS letters 1996;395(1):73-6.
1996: Marie-Anne Robin; M Maratrat; M Le Roy; F P Le Breton; Eric Bonierbale; Patrick M Dansette; F Ballet; Daniel Mansuy; Dominique Pessayre
Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.
The Journal of clinical investigation 1996;98(6):1471-80.
1996: M A Kopf; D Bonnet; Isabelle Artaud; D Pétré; Daniel Mansuy
Key role of alkanoic acids on the spectral properties, activity, and active-site stability of iron-containing nitrile hydratase from Brevibacterium R312.
European journal of biochemistry / FEBS 1996;240(1):239-44.
1996: Marie-Agnès Sari; S Booker; Maryse Jaouen; S Vadon; J I Boucher; Denis Pompon; Daniel Mansuy
Expression in yeast and purification of functional macrophage nitric oxide synthase. Evidence for cysteine-194 as iron proximal ligand.
Biochemistry 1996;35(22):7204-13.
1996: S Gaspard; G Chottard; Jean-Pierre Mahy; Daniel Mansuy
Study of the coordination chemistry of prostaglandin G/H synthase by resonance Raman spectroscopy.
European journal of biochemistry / FEBS 1996;238(2):529-37.
1996: C Pons; Patrick M Dansette; J Gregeois; J C Homberg; E E Billett; Daniel Mansuy
Human anti-mitochondria autoantibodies appearing in iproniazid-induced immunoallergic hepatitis recognize human liver monoamine oxidase B.
Biochemical and biophysical research communications 1996;218(1):118-24.
1996: Philippe Beaune; Sylvaine Lecoeur; M Bourdi; A Gauffre; C Belloc; Patrick M Dansette; Daniel Mansuy
Anti-cytochrome P450 autoantibodies in drug-induced disease.
European journal of haematology. Supplementum 1996;60():89-92.
1996: Daniel Mansuy; Patrick M Dansette
New biological reactive intermediates: metabolic activation of thiophene derivatives.
Advances in experimental medicine and biology 1996;387():1-6.
1995: A Mancy; P Broto; Sylvie Dijols; Patrick M Dansette; Daniel Mansuy
The substrate binding site of human liver cytochrome P450 2C9: an approach using designed tienilic acid derivatives and molecular modeling.
Biochemistry 1995;34(33):10365-75.
1995: M Sedqi; Marcel Delaforge; Daniel Mansuy; B Martin; P Jollès; D Migliore-Samour
Immunostimulating lipopeptide, LtriP (RP 56142): comparison of the effect on hepatic cytochrome P 450 modulation and radioprotection in male and female of three mouse strains.
Experientia 1995;51(8):790-8.
1995: C Bensoussan; Marcel Delaforge; Daniel Mansuy
Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs.
Biochemical pharmacology 1995;49(5):591-602.
1995: Daniel Mansuy; Jean-Luc Boucher; Bernd Clement
On the mechanism of nitric oxide formation upon oxidative cleavage of C = N(OH) bonds by NO-synthases and cytochromes P450.
Biochimie 1995;77(7-8):661-7.
1995: Daniel Mansuy
Cytochromes P450 and drug toxicity. Immunological consequences.
Clinical reviews in allergy & immunology 1995;13(3):201-9.
1995: I Tomasi; Isabelle Artaud; Yves A. Bertheau; Daniel Mansuy
Metabolism of polychlorinated phenols by Pseudomonas cepacia AC1100: determination of the first two steps and specific inhibitory effect of methimazole.
Journal of bacteriology 1995;177(2):307-11.
1994: Jean-Pierre Mahy; S Gaspard; Marcel Delaforge; Daniel Mansuy
Reactions of prostaglandin H synthase with monosubstituted hydrazines and diazenes. Formation of iron(II)-diazene and iron(III)-sigma-alkyl or iron(III)-sigma-aryl complexes.
European journal of biochemistry / FEBS 1994;226(2):445-57.
1994: Jean-Luc Boucher; J Custot; S Vadon; Marcel Delaforge; Michel Lepoivre; Jean-Pierre Tenu; A Yapo; Daniel Mansuy
N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase.
Biochemical and biophysical research communications 1994;203(3):1614-21.
1994: M A Peyronneau; Marcel Delaforge; R Riviere; J P Renaud; Daniel Mansuy
High affinity of ergopeptides for cytochromes P450 3A. Importance of their peptide moiety for P450 recognition and hydroxylation of bromocriptine.
European journal of biochemistry / FEBS 1994;223(3):947-56.
1994: Jean-Luc Boucher; Marcel Delaforge; Daniel Mansuy
Dehydration of alkyl- and arylaldoximes as a new cytochrome P450-catalyzed reaction: mechanism and stereochemical characteristics.
Biochemistry 1994;33(25):7811-8.
1994: Sylvaine Lecoeur; Eric Bonierbale; D Challine; J C Gautier; P Valadon; Patrick M Dansette; R Catinot; F Ballet; Daniel Mansuy; Philippe Beaune
Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs.
Chemical research in toxicology 1994;7(3):434-42.
1994: M Pilar Lopez-Garcia; Patrick M Dansette; Daniel Mansuy
Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid.
Biochemistry 1994;33(1):166-75.
1993: M A Peyronneau; J P Renaud; Maryse Jaouen; Philippe Urban; Christophe Cullin; Denis Pompon; Daniel Mansuy
Expression in yeast of three allelic cDNAs coding for human liver P-450 3A4. Different stabilities, binding properties and catalytic activities of the yeast-produced enzymes.
European journal of biochemistry / FEBS 1993;218(2):355-61.
1993: J P Renaud; M A Peyronneau; Philippe Urban; Gilles Truan; Christophe Cullin; Denis Pompon; P Beaune; Daniel Mansuy
Recombinant yeast in drug metabolism.
Toxicology 1993;82(1-3):39-52.
1993: Jean-Pierre Mahy; S Gaspard; Daniel Mansuy
Phenylhydrazones as new good substrates for the dioxygenase and peroxidase reactions of prostaglandin synthase: formation of iron(III)-sigma-phenyl complexes.
Biochemistry 1993;32(15):4014-21.
1993: J P Renaud; Jean-Luc Boucher; S Vadon; Marcel Delaforge; Daniel Mansuy
Particular ability of liver P450s3A to catalyze the oxidation of N omega-hydroxyarginine to citrulline and nitrogen oxides and occurrence in no synthases of a sequence very similar to the heme-binding sequence in P450s.
Biochemical and biophysical research communications 1993;192(1):53-60.
1993: M Pilar Lopez-Garcia; Patrick M Dansette; P Valadon; C Amar; Philippe Beaune; F P Guengerich; Daniel Mansuy
Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10.
European journal of biochemistry / FEBS 1993;213(1):223-32.
1993: M Atta; N Lamarche; J P Battioni; Bernard Massie; Yves Langelier; Daniel Mansuy; Marc Fontecave
Escherichia coli and herpes-simplex-virus ribonucleotide reductase R2 subunit. Compared reactivities of the redox centres.
The Biochemical journal 1993;290 ( Pt 3)():807-10.
1993: Marcel Delaforge; D Servent; P Wirsta; Claire Ducrocq; Daniel Mansuy; M Lenfant
Particular ability of cytochrome P-450 CYP3A to reduce glyceryl trinitrate in rat liver microsomes: subsequent formation of nitric oxide.
Chemico-biological interactions 1993;86(2):103-17.
1992: Jean-Luc Boucher; A Genet; S Vadon; Marcel Delaforge; Yves Henry; Daniel Mansuy
Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline.
Biochemical and biophysical research communications 1992;187(2):880-6.
1992: Patrick M Dansette; D C Thang; H el Amri; Daniel Mansuy
Evidence for thiophene-S-oxide as a primary reactive metabolite of thiophene in vivo: formation of a dihydrothiophene sulfoxide mercapturic acid.
Biochemical and biophysical research communications 1992;186(3):1624-30.
1992: M A Peyronneau; J P Renaud; Gilles Truan; Philippe Urban; Denis Pompon; Daniel Mansuy
Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5.
European journal of biochemistry / FEBS 1992;207(1):109-16.
1992: V Andronik-Lion; Jean-Luc Boucher; Marcel Delaforge; Yves Henry; Daniel Mansuy
Formation of nitric oxide by cytochrome P450-catalyzed oxidation of aromatic amidoximes.
Biochemical and biophysical research communications 1992;185(1):452-8.
1992: Jean-Luc Boucher; A Genet; S Vadon; Marcel Delaforge; Daniel Mansuy
Formation of nitrogen oxides and citrulline upon oxidation of N omega-hydroxy-L-arginine by hemeproteins.
Biochemical and biophysical research communications 1992;184(3):1158-64.
1992: C Martinat; C Amar; Patrick M Dansette; J Leclaire; P Lopez-Garcia; T D Cao; H N N'Guyen; Daniel Mansuy
In vitro metabolism of isaxonine phosphate: formation of two metabolites, 5-hydroxyisaxonine and 2-aminopyrimidine, and covalent binding to microsomal proteins.
European journal of pharmacology 1992;228(1):63-71.
1991: C Pons; Patrick M Dansette; C Amar; Maryse Jaouen; C R Wolf; J Gregeois; J C Homberg; Daniel Mansuy
Detection of human hepatitis anti-liver kidney microsomes (LKM2) autoantibodies on rat liver sections is predominantly due to reactivity with rat liver P-450 IIC11.
The Journal of pharmacology and experimental therapeutics 1991;259(3):1328-34.
1991: C Cucurou; J P Battioni; D C Thang; N H Nam; Daniel Mansuy
Mechanisms of inactivation of lipoxygenases by phenidone and BW755C.
Biochemistry 1991;30(37):8964-70.
1991: Jean-Luc Boucher; Marcel Delaforge; Daniel Mansuy
Metabolism of lipoxins A4 and B4 and of their all-trans isomers by human leukocytes and rat liver microsomes.
Biochemical and biophysical research communications 1991;177(1):134-9.
1991: Jean-Pierre Mahy; Daniel Mansuy
Formation of prostaglandin synthase-iron-nitrosoalkane inhibitory complexes upon in situ oxidation of N-substituted hydroxylamines.
Biochemistry 1991;30(17):4165-72.
1991: Patrick M Dansette; C Amar; P Valadon; C Pons; Philippe Beaune; Daniel Mansuy
Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation.
Biochemical pharmacology 1991;41(4):553-60.
1991: J P Battioni; Marc Fontecave; Maryse Jaouen; Daniel Mansuy
Vitamin E derivatives as new potent inhibitors of microsomal lipid peroxidation.
Biochemical and biophysical research communications 1991;174(3):1103-8.
1991: C Cucurou; J P Battioni; R Daniel; Daniel Mansuy
Peroxidase-like activity of lipoxygenases: different substrate specificity of potato 5-lipoxygenase and soybean 15-lipoxygenase and particular affinity of vitamin E derivatives for the 5-lipoxygenase.
Biochimica et biophysica acta 1991;1081(1):99-105.
1991: Daniel Mansuy
Formation of reactive metabolites and appearance of anti-organelle antibodies in man.
Advances in experimental medicine and biology 1991;283():133-7.
1990: Marc Fontecave; Maryse Jaouen; Daniel Mansuy; D Costa; R Zalma; H Pezerat
Microsomal lipid peroxidation and oxy-radicals formation are induced by insoluble iron-containing minerals.
Biochemical and biophysical research communications 1990;173(3):912-8.
1990: J P Renaud; Christophe Cullin; Denis Pompon; P Beaune; Daniel Mansuy
Expression of human liver cytochrome P450 IIIA4 in yeast. A functional model for the hepatic enzyme.
European journal of biochemistry / FEBS 1990;194(3):889-96.
1990: I Michaud-Soret; R Daniel; C Chopard; Daniel Mansuy; C Cucurou; Volker Ullrich; Jean-Claude Chottard
Soybean lipoxygenases-1, -2a, -2b and -2c do not contain PQQ.
Biochemical and biophysical research communications 1990;172(3):1122-8.
1990: A S Boutorine; T Le Doan; J P Battioni; Daniel Mansuy; D Dupré; Claude Hélène
Rapid routes of synthesis of chemically reactive and highly radioactively labeled alpha- and beta-oligonucleotide derivatives for in vivo studies.
Bioconjugate chemistry 1990;1(5):350-6.
1990: Marc Fontecave; Catherine Gerez; Daniel Mansuy; Peter Reichard
Reduction of the Fe(III)-tyrosyl radical center of Escherichia coli ribonucleotide reductase by dithiothreitol.
The Journal of biological chemistry 1990;265(19):10919-24.
1990: Marie-Agnès Sari; J P Battioni; D Dupré; Daniel Mansuy; J B Le Pecq
Interaction of cationic porphyrins with DNA: importance of the number and position of the charges and minimum structural requirements for intercalation.
Biochemistry 1990;29(17):4205-15.
1990: E Neau; Patrick M Dansette; V Andronik; Daniel Mansuy
Hydroxylation of the thiophene ring by hepatic monooxygenases. Evidence for 5-hydroxylation of 2-aroylthiophenes as a general metabolic pathway using a simple UV-visible assay.
Biochemical pharmacology 1990;39(6):1101-7.
1990: Patrick M Dansette; C Amar; C Smith; C Pons; Daniel Mansuy
Oxidative activation of the thiophene ring by hepatic enzymes. Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes.
Biochemical pharmacology 1990;39(5):911-8.
1990: Patrick M Dansette; A Sassi; C Deschamps; Daniel Mansuy
Sulfur containing compounds as antioxidants.
Advances in experimental medicine and biology 1990;264():209-15.
1989: D Servent; Marcel Delaforge; Claire Ducrocq; Daniel Mansuy; M Lenfant
Nitric oxide formation during microsomal hepatic denitration of glyceryl trinitrate: involvement of cytochrome P-450.
Biochemical and biophysical research communications 1989;163(3):1210-6.
1989: D Migliore-Samour; Marcel Delaforge; Maryse Jaouen; Daniel Mansuy; P Jollès
In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity.
Experientia 1989;45(9):882-6.
1989: Daniel Mansuy; P Battioni; J P Battioni
Chemical model systems for drug-metabolizing cytochrome-P-450-dependent monooxygenases.
European journal of biochemistry / FEBS 1989;184(2):267-85.
1989: E Sartori; Marcel Delaforge; Daniel Mansuy
In vitro interaction of rat liver cytochromes P-450 with erythromycin, oleandomycin and erythralosamine derivatives. Importance of structural factors.
Biochemical pharmacology 1989;38(13):2061-8.
1989: O Reinaud; Marcel Delaforge; Jean-Luc Boucher; F Rocchiccioli; Daniel Mansuy
Oxidative metabolism of linoleic acid by human leukocytes.
Biochemical and biophysical research communications 1989;161(2):883-91.
1989: Daniel Mansuy; Jean-Luc Boucher; Marcel Delaforge; J Leclaire
Hydroxylation of leukotriene B4 in leukocytes from various species: identification of a metabolite to authentic 5S,12R,19-trihydroxy-6Z,8E,10E,14Z-eicosatetra enoic acid and relative importance of 19- and 20-hydroxylations.
Biochemical and biophysical research communications 1989;159(3):1283-9.
1988: Marie-Agnès Sari; J P Battioni; D Dupre; Daniel Mansuy; J B Le Pecq
Cationic porphyrin-DNA interactions: importance of the number and position of the charges.
Biochemical pharmacology 1988;37(9):1861-2.
1988: Daniel Mansuy; C Cucurou; B Biatry; J P Battioni
Soybean lipoxygenase-catalyzed oxidations by linoleic acid hydroperoxide: different reducing substrates and dehydrogenation of phenidone and BW 755C.
Biochemical and biophysical research communications 1988;151(1):339-46.
1988: Jean-Baptiste GALEY; Sophie Bombard; C Chopard; J J Girerd; F Lederer; D C Thang; N H Nam; Daniel Mansuy; Jean-Claude Chottard
Hexanal phenylhydrazone is a mechanism-based inactivator of soybean lipoxygenase 1.
Biochemistry 1988;27(3):1058-66.
1988: Marcel Delaforge; E Sartori; Daniel Mansuy
In vivo and in vitro effects of a new macrolide antibiotic roxithromycin on rat liver cytochrome P-450: comparison with troleandomycin and erythromycin.
Chemico-biological interactions 1988;68(3-4):179-88.
1987: Marc Fontecave; Daniel Mansuy; Maryse Jaouen; H Pezerat
The stimulatory effects of asbestos on NADPH-dependent lipid peroxidation in rat liver microsomes.
The Biochemical journal 1987;241(2):561-5.
1987: P Beaune; Patrick M Dansette; Daniel Mansuy; L Kiffel; M Finck; C Amar; J P Leroux; J C Homberg
Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(2):551-5.
1986: Marie-Agnès Sari; J P Battioni; Daniel Mansuy; J B Le Pecq
Mode of interaction and apparent binding constants of meso-tetraaryl porphyrins bearing between one and four positive charges with DNA.
Biochemical and biophysical research communications 1986;141(2):643-9.
1986: Marcel Delaforge; P Battioni; Jean-Pierre Mahy; Daniel Mansuy
In vivo formation of sigma-methyl- and sigma-phenyl-ferric complexes of hemoglobin and liver-cytochrome P-450 upon treatment of rats with methyl- and phenylhydrazine.
Chemico-biological interactions 1986;60(1):101-13.
1986: Patrick M Dansette; Marcel Delaforge; E Sartori; P Beaune; Maryse Jaouen; Daniel Mansuy
Drug interactions with macrolide antibiotics: specificity of pseudo-suicide inhibition and induction of cytochrome P-450.
Advances in experimental medicine and biology 1986;197():155-62.
1985: E Sartori; Marcel Delaforge; Daniel Mansuy; P Beaune
Some erythromycin derivatives are strong inducers in rats of a cytochrome P-450 very similar to that induced by 16 alpha-pregnenolone carbonitrile.
Biochemical and biophysical research communications 1985;128(3):1434-9.
1984: Marcel Delaforge; Maryse Jaouen; Daniel Mansuy
The cytochrome P-450 metabolite complex derived from troleandomycin: properties in vitro and stability in vivo.
Chemico-biological interactions 1984;51(3):371-6.
1984: Daniel Mansuy; Patrick M Dansette; C Foures; Maryse Jaouen; G Moinet; N Bayer
Metabolic hydroxylation of the thiophene ring: isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rat.
Biochemical pharmacology 1984;33(9):1429-35.
1983: P Battioni; Jean-Pierre Mahy; Marcel Delaforge; Daniel Mansuy
Reaction of monosubstituted hydrazines and diazenes with rat-liver cytochrome P450. Formation of ferrous-diazene and ferric sigma-alkyl complexes.
European journal of biochemistry / FEBS 1983;134(2):241-8.
1983: Marcel Delaforge; Maryse Jaouen; Daniel Mansuy
Dual effects of macrolide antibiotics on rat liver cytochrome P-450. Induction and formation of metabolite-complexes: a structure-activity relationship.
Biochemical pharmacology 1983;32(15):2309-18.
1982: Daniel Mansuy; P Battioni; Jean-Pierre Mahy; G Gillet
Comparison of the hemoglobin reactions with methyl- and phenyl-hydrazine; intermediate formation of a hemoglobin Fe-(II)-methyldiazene complex.
Biochemical and biophysical research communications 1982;106(1):30-6.