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Jaswir Basran

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Sara A Rafice; Nishma Chauhan; Igor Efimov; Jaswir Basran; Emma Lloyd Raven
Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase.
Emma J Murphy; Clive L Metcalfe; Jaswir Basran; Peter C E Moody; Emma Lloyd Raven
Engineering the substrate specificity and reactivity of a heme protein: creation of an ascorbate binding site in cytochrome c peroxidase.
Kate L Wegener; Jaswir Basran; Clive R Bagshaw; Iain D Campbell; Gordon Roberts; David R Critchley; Igor L Barsukov
Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.

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All Publications

2009: Sara A Rafice; Nishma Chauhan; Igor Efimov; Jaswir Basran; Emma Lloyd Raven
Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase.
Biochemical Society transactions 2009;37(Pt 2):408-12.
2008: Emma J Murphy; Clive L Metcalfe; Jaswir Basran; Peter C E Moody; Emma Lloyd Raven
Engineering the substrate specificity and reactivity of a heme protein: creation of an ascorbate binding site in cytochrome c peroxidase.
Biochemistry 2008;47(52):13933-41.
2008: Kate L Wegener; Jaswir Basran; Clive R Bagshaw; Iain D Campbell; Gordon Roberts; David R Critchley; Igor L Barsukov
Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.
Journal of molecular biology 2008;382(1):112-26.
2008: Alexandre R Gingras; Jaswir Basran; Andrew Prescott; Marina Kriajevska; Clive R Bagshaw; Igor L Barsukov
Crystal structure of the Ca(2+)-form and Ca(2+)-binding kinetics of metastasis-associated protein, S100A4.
FEBS letters 2008;582(12):1651-6.
2008: Nishma Chauhan; Jaswir Basran; Igor Efimov; Dimitri A Svistunenko; Harriet E Seward; Peter C E Moody; Emma Lloyd Raven
The role of serine 167 in human indoleamine 2,3-dioxygenase: a comparison with tryptophan 2,3-dioxygenase.
Biochemistry 2008;47(16):4761-9.
2008: Jaswir Basran; Sara A Rafice; Nishma Chauhan; Igor Efimov; Myles R Cheesman; Lila Ghamsari; Emma Lloyd Raven
A kinetic, spectroscopic, and redox study of human tryptophan 2,3-dioxygenase.
Biochemistry 2008;47(16):4752-60.
2008: Sandip K Badyal; Clive L Metcalfe; Jaswir Basran; Igor Efimov; Peter C E Moody; Emma Lloyd Raven
Iron oxidation state modulates active site structure in a heme peroxidase.
Biochemistry 2008;47(15):4403-9.
2007: Xinghua Shi; Jaswir Basran; Harriet E Seward; William Childs; Clive R Bagshaw; Steven G Boxer
Anomalous negative fluorescence anisotropy in yellow fluorescent protein (YFP 10C): quantitative analysis of FRET in YFP dimers.
Biochemistry 2007;46(50):14403-17.
2007: Zoi Pipirou; Andrew Bottrill; Dimitri A Svistunenko; Igor Efimov; Jaswir Basran; Sharad C Mistry; Chris E Cooper; Emma Lloyd Raven
The reactivity of heme in biological systems: autocatalytic formation of both tyrosine-heme and tryptophan-heme covalent links in a single protein architecture.
Biochemistry 2007;46(46):13269-78.
2006: Jaswir Basran; Stephen Fullerton; David Leys; Nigel S Scrutton
Mechanism of FAD reduction and role of active site residues His-225 and Tyr-259 in Arthrobacter globiformis dimethylglycine oxidase: analysis of mutant structure and catalytic function.
Biochemistry 2006;45(37):11151-61.
2006: Wei Zeng; Harriet E Seward; András Málnási-Csizmadia; Stuart Wakelin; Robert J Woolley; Gurpreet S Cheema; Jaswir Basran; Trushar R Patel; Arthur J Rowe; Clive R Bagshaw
Resonance energy transfer between green fluorescent protein variants: complexities revealed with myosin fusion proteins.
Biochemistry 2006;45(35):10482-91.
2006: Michael J Sutcliffe; Laura Masgrau; Anna Roujeinikova; Linus Johannissen; Parvinder Hothi; Jaswir Basran; Kara Ranaghan; Adrian J Mulholland; David Leys; Nigel S Scrutton
Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006;361(1472):1375-86.
2006: Sandip K Badyal; M Gordon Joyce; Katherine H Sharp; Harriet E Seward; Martin Mewies; Jaswir Basran; Isabel K Macdonald; Peter C E Moody; Emma Lloyd Raven
Conformational mobility in the active site of a heme peroxidase.
The Journal of biological chemistry 2006;281(34):24512-20.
2006: Jonathan P Combe; Jaswir Basran; Parvinder Hothi; David Leys; Stephen E J Rigby; Andrew W Munro; Nigel S Scrutton
Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis.
The Journal of biological chemistry 2006;281(26):17977-88.
2006: Laura Masgrau; Anna Roujeinikova; Linus Johannissen; Parvinder Hothi; Jaswir Basran; Kara Ranaghan; Adrian J Mulholland; Michael J Sutcliffe; Nigel S Scrutton; David Leys
Atomic description of an enzyme reaction dominated by proton tunneling.
Science (New York, N.Y.) 2006;312(5771):237-41.
2005: Fabio Polticelli; Jaswir Basran; Carmen Faso; Alessandra Cona; Giovanni Minervini; Riccardo Angelini; Rodolfo Federico; Nigel S Scrutton; Paraskevi Tavladoraki
Lys300 plays a major role in the catalytic mechanism of maize polyamine oxidase.
Biochemistry 2005;44(49):16108-20.
2005: Stephen E J Rigby; Jaswir Basran; Jonathan P Combe; Al-Walid A Mohsen; Helen S Toogood; Adam van Thiel; Michael J Sutcliffe; David Leys; Andrew W Munro; Nigel S Scrutton
Flavoenzyme catalysed oxidation of amines: roles for flavin and protein-based radicals.
Biochemical Society transactions 2005;33(Pt 4):754-7.
2004: Laura Masgrau; Jaswir Basran; Parvinder Hothi; Michael J Sutcliffe; Nigel S Scrutton
Hydrogen tunneling in quinoproteins.
Archives of biochemistry and biophysics 2004;428(1):41-51.
2004: Helen S Toogood; Adam van Thiel; Jaswir Basran; Michael J Sutcliffe; Nigel S Scrutton; David Leys
Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex.
The Journal of biological chemistry 2004;279(31):32904-12.
2004: David Leys; Jaswir Basran; François Talfournier; Kamaldeep K Chohan; Andrew W Munro; Michael J Sutcliffe; Nigel S Scrutton
Flavin radicals, conformational sampling and robust design principles in interprotein electron transfer: the trimethylamine dehydrogenase-electron-transferring flavoprotein complex.
Biochemical Society symposium 2004;(71):1-14.
2003: Jaswir Basran; Richard J Harris; Michael J Sutcliffe; Nigel S Scrutton
H-tunneling in the multiple H-transfers of the catalytic cycle of morphinone reductase and in the reductive half-reaction of the homologous pentaerythritol tetranitrate reductase.
The Journal of biological chemistry 2003;278(45):43973-82.
2003: David Leys; Jaswir Basran; Nigel S Scrutton
Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase.
The EMBO journal 2003;22(16):4038-48.
2003: Parvinder Hothi; Jaswir Basran; Michael J Sutcliffe; Nigel S Scrutton
Effects of multiple ligand binding on kinetic isotope effects in PQQ-dependent methanol dehydrogenase.
Biochemistry 2003;42(13):3966-78.
2003: Kirsten R Wolthers; Jaswir Basran; Andrew W Munro; Nigel S Scrutton
Molecular dissection of human methionine synthase reductase: determination of the flavin redox potentials in full-length enzyme and isolated flavin-binding domains.
Biochemistry 2003;42(13):3911-20.
2003: Robert D Finn; Jaswir Basran; Olivier Roitel; C Roland Wolf; Andrew W Munro; Mark Paine; Nigel S Scrutton
Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1.
European journal of biochemistry / FEBS 2003;270(6):1164-75.
2003: David Leys; Jaswir Basran; François Talfournier; Michael J Sutcliffe; Nigel S Scrutton
Extensive conformational sampling in a ternary electron transfer complex.
Nature structural biology 2003;10(3):219-25.
2003: Claudia Loechel; Amrik Basran; Jaswir Basran; Nigel S Scrutton; Elizabeth A H Hall
Using trimethylamine dehydrogenase in an enzyme linked amperometric electrode. Part 1. Wild-type enzyme redox mediation.
The Analyst 2003;128(2):166-72.
2002: Latesh Lad; Martin Mewies; Jaswir Basran; Nigel S Scrutton; Emma Lloyd Raven
Role of histidine 42 in ascorbate peroxidase. Kinetic analysis of the H42A and H42E variants.
European journal of biochemistry / FEBS 2002;269(13):3182-92.
2002: Jaswir Basran; Nina Bhanji; Amrik Basran; Daniel Nietlispach; Sharad C Mistry; Rolandas Meskys; Nigel S Scrutton
Mechanistic aspects of the covalent flavoprotein dimethylglycine oxidase of Arthrobacter globiformis studied by stopped-flow spectrophotometry.
Biochemistry 2002;41(14):4733-43.
2001: Jaswir Basran; Michael J Sutcliffe; Nigel S Scrutton
Optimizing the Michaelis complex of trimethylamine dehydrogenase: identification of interactions that perturb the ionization of substrate and facilitate catalysis with trimethylamine base.
The Journal of biological chemistry 2001;276(46):42887-92.
2001: Jaswir Basran; Michael J Sutcliffe; Nigel S Scrutton
Deuterium isotope effects during carbon-hydrogen bond cleavage by trimethylamine dehydrogenase. Implications for mechanism and vibrationally assisted hydrogen tunneling in wild-type and mutant enzymes.
The Journal of biological chemistry 2001;276(27):24581-7.
2001: François Talfournier; Andrew W Munro; Jaswir Basran; Michael J Sutcliffe; Simon Daff; Stephen K Chapman; Nigel S Scrutton
alpha Arg-237 in Methylophilus methylotrophus (sp. W3A1) electron-transferring flavoprotein affords approximately 200-millivolt stabilization of the FAD anionic semiquinone and a kinetic block on full reduction to the dihydroquinone.
The Journal of biological chemistry 2001;276(23):20190-6.
2001: Rolandas Meskys; Richard J Harris; V Casaite; Jaswir Basran; Nigel S Scrutton
Organization of the genes involved in dimethylglycine and sarcosine degradation in Arthrobacter spp.: implications for glycine betaine catabolism.
European journal of biochemistry / FEBS 2001;268(12):3390-8.
2001: Jaswir Basran; S Patel; Michael J Sutcliffe; Nigel S Scrutton
Importance of barrier shape in enzyme-catalyzed reactions. Vibrationally assisted hydrogen tunneling in tryptophan tryptophylquinone-dependent amine dehydrogenases.
The Journal of biological chemistry 2001;276(9):6234-42.
2000: Jaswir Basran; Kamaldeep K Chohan; Michael J Sutcliffe; Nigel S Scrutton
Differential coupling through Val-344 and Tyr-442 of trimethylamine dehydrogenase in electron transfer reactions with ferricenium ions and electron transferring flavoprotein.
Biochemistry 2000;39(31):9188-200.
2000: P Trickey; Jaswir Basran; L Y Lian; Z Chen; John D Barton; M J Sutcliffe; Nigel Scrutton; F Scott Mathews
Structural and biochemical characterization of recombinant wild type and a C30A mutant of trimethylamine dehydrogenase from methylophilus methylotrophus (sp. W(3)A(1)).
Biochemistry 2000;39(26):7678-88.
1999: P Roberts; Jaswir Basran; EK Wilson; R Hille; Nigel S Scrutton
Redox cycles in trimethylamine dehydrogenase and mechanism of substrate inhibition.
Biochemistry 1999;38(45):14927-40.
1999: Nigel S Scrutton; Jaswir Basran; Michael J Sutcliffe
New insights into enzyme catalysis. Ground state tunnelling driven by protein dynamics.
European journal of biochemistry / FEBS 1999;264(3):666-71.
1999: Jaswir Basran; Michael J Sutcliffe; R Hille; Nigel S Scrutton
Reductive half-reaction of the H172Q mutant of trimethylamine dehydrogenase: evidence against a carbanion mechanism and assignment of kinetically influential ionizations in the enzyme-substrate complex.
The Biochemical journal 1999;341 ( Pt 2)():307-14.
1999: Marco G Casarotto; Jaswir Basran; R Badii; Kong Hung SZE; Gordon Roberts
Direct measurement of the pKa of aspartic acid 26 in Lactobacillus casei dihydrofolate reductase: implications for the catalytic mechanism.
Biochemistry 1999;38(25):8038-44.
1999: Jaswir Basran; M H Jang; Michael J Sutcliffe; R Hille; Nigel S Scrutton
The role of Tyr-169 of trimethylamine dehydrogenase in substrate oxidation and magnetic interaction between FMN cofactor and the 4Fe/4S center.
The Journal of biological chemistry 1999;274(19):13155-61.
1999: Jaswir Basran; Michael J Sutcliffe; Nigel S Scrutton
Enzymatic H-transfer requires vibration-driven extreme tunneling.
Biochemistry 1999;38(10):3218-22.
1999: Nigel S Scrutton; Jaswir Basran; EK Wilson; Kamaldeep K Chohan; M H Jang; Michael J Sutcliffe; R Hille
Electron transfer in trimethylamine dehydrogenase and electron-transferring flavoprotein.
Biochemical Society transactions 1999;27(2):196-201.
1998: H J Lee; Jaswir Basran; Nigel S Scrutton
Electron transfer from flavin to iron in the Pseudomonas oleovorans rubredoxin reductase-rubredoxin electron transfer complex.
Biochemistry 1998;37(44):15513-22.
1997: Jaswir Basran; Marco G Casarotto; Amrik Basran; Gordon Roberts
Effects of single-residue substitutions on negative cooperativity in ligand binding to dihydrofolate reductase.
Protein engineering 1997;10(7):815-26.
1997: Martin Mewies; Jaswir Basran; L C Packman; R Hille; Nigel S Scrutton
Involvement of a flavin iminoquinone methide in the formation of 6-hydroxyflavin mononucleotide in trimethylamine dehydrogenase: a rationale for the existence of 8alpha-methyl and C6-linked covalent flavoproteins.
Biochemistry 1997;36(23):7162-8.
1997: Jaswir Basran; Martin Mewies; F S Mathews; Nigel S Scrutton
Selective modification of alkylammonium ion specificity in trimethylamine dehydrogenase by the rational engineering of cation-pi bonding.
Biochemistry 1997;36(8):1989-98.
1997: Berry Birdsall; Marco G Casarotto; H T Cheung; Jaswir Basran; Gordon Roberts; James Feeney
The influence of aspartate 26 on the tautomeric forms of folate bound to Lactobacillus casei dihydrofolate reductase.
FEBS letters 1997;402(2-3):157-61.
1995: R Badii; Jaswir Basran; Marco G Casarotto; Gordon Roberts
High-level expression and isotopic labeling of Lactobacillus casei dihydrofolate reductase for nuclear magnetic resonance spectroscopy.
Protein expression and purification 1995;6(3):237-43.
1995: Jaswir Basran; Marco G Casarotto; Igor Barsukov; Gordon Roberts
Role of the active-site carboxylate in dihydrofolate reductase: kinetic and spectroscopic studies of the aspartate 26-->asparagine mutant of the Lactobacillus casei enzyme.
Biochemistry 1995;34(9):2872-82.
1994: J A Thomas; J R Arnold; Jaswir Basran; J Andrews; Gordon Roberts; Berry Birdsall; James Feeney
Effects of substitution of Thr63 by alanine on the structure and function of Lactobacillus casei dihydrofolate reductase.
Protein engineering 1994;7(6):783-92.