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Samuel Mantey

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Hirotsugu Uehara; Tatsuro Katsuno; Samuel A Mantey; Tomoo Nakagawa; David H Coy; Nieves González; Simon J Hocart; Robert T Jensen
The molecular basis for high affinity of a universal ligand for human bombesin receptor (BnR) family members.
Hirotsugu Uehara; David H Coy; Nieves González; Samuel A Mantey; Bernardo Nuche-Berenguer; Tapas K Pradhan; Veronica Sancho; Robert T Jensen
Pharmacology and selectivity of various natural and synthetic bombesin related peptide agonists for human and rat bombesin receptors differs.
Terry W Moody; Bernardo Nuche-Berenguer; Veronica Sancho; Alessia di Florio; Samuel A Mantey; Robert T Jensen
Bombesin receptor subtype-3 agonists stimulate the growth of lung cancer cells and increase EGF receptor tyrosine phosphorylation.

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All Publications

2012: Hirotsugu Uehara; Tatsuro Katsuno; Samuel A Mantey; Tomoo Nakagawa; David H Coy; Nieves González; Simon J Hocart; Robert T Jensen
The molecular basis for high affinity of a universal ligand for human bombesin receptor (BnR) family members.
Biochemical pharmacology 2012;84(7):936-48.
2011: Hirotsugu Uehara; David H Coy; Nieves González; Samuel A Mantey; Bernardo Nuche-Berenguer; Tapas K Pradhan; Veronica Sancho; Robert T Jensen
Pharmacology and selectivity of various natural and synthetic bombesin related peptide agonists for human and rat bombesin receptors differs.
Peptides 2011;32(8):1685-99.
2011: Terry W Moody; Bernardo Nuche-Berenguer; Veronica Sancho; Alessia di Florio; Samuel A Mantey; Robert T Jensen
Bombesin receptor subtype-3 agonists stimulate the growth of lung cancer cells and increase EGF receptor tyrosine phosphorylation.
Peptides 2011;32(8):1677-84.
2010: Veronica Sancho; Terry W Moody; Samuel A Mantey; Alessia Di Florio; Hirotsugu Uehara; David H Coy; Robert T Jensen
Pharmacology of putative selective hBRS-3 receptor agonists for human bombesin receptors (BnR): affinities, potencies and selectivity in multiple native and BnR transfected cells.
Peptides 2010;31(8):1569-78.
2010: Terry W Moody; Marc J Berna; Samuel A Mantey; Veronica Sancho; Lisa A Ridnour; David A Wink; Daniel Chan; Giuseppe Giaccone; Robert T Jensen
Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells.
European journal of pharmacology 2010;637(1-3):38-45.
2009: Nieves González; Tomoo Nakagawa; Samuel A Mantey; Veronica Sancho; Hirotsugu Uehara; Tatsuro Katsuno; Robert T Jensen
Molecular basis for the selectivity of the mammalian bombesin peptide, neuromedin B, for its receptor.
The Journal of pharmacology and experimental therapeutics 2009;331(1):265-76.
2009: Nieves González; Samuel A Mantey; Tapas K Pradhan; Veronica Sancho; Terry W Moody; David H Coy; Robert T Jensen
Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors.
Peptides 2009;30(8):1473-86.
2008: Terry W Moody; Tapas Pradhan; Samuel A Mantey; Robert T Jensen; Marcin Dyba; Deborah Moody; Nadya I Tarasova; Christopher J Michejda
Bombesin marine toxin conjugates inhibit the growth of lung cancer cells.
Life sciences 2008;82(15-16):855-61.
2008: Michael Schumann; Tomoo Nakagawa; Samuel A Mantey; Brian Howell; Robert T Jensen
Function of non-visual arrestins in signaling and endocytosis of the gastrin-releasing peptide receptor (GRP receptor).
Biochemical pharmacology 2008;75(5):1170-85.
2008: Nieves González; Simon J Hocart; Sergio Portal-Nuñez; Samuel A Mantey; Tomoo Nakagawa; Enrique Zudaire; David H Coy; Robert T Jensen
Molecular basis for agonist selectivity and activation of the orphan bombesin receptor subtype 3 receptor.
The Journal of pharmacology and experimental therapeutics 2008;324(2):463-74.
2007: Terry W Moody; Samuel A Mantey; Joseph A Fuselier; David H Coy; Robert T Jensen
Vasoactive intestinal peptide-camptothecin conjugates inhibit the proliferation of breast cancer cells.
Peptides 2007;28(9):1883-90.
2007: Marc J Berna; K Martin Hoffmann; Jose Tapia; Michelle Thill; Andrea Pace; Samuel A Mantey; Robert T Jensen
CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways.
Biochimica et biophysica acta 2007;1773(4):483-501.
2006: K Martin Hoffmann; Jose Tapia; Marc J Berna; Michelle Thill; Till Braunschweig; Samuel A Mantey; Terry W Moody; Robert T Jensen
Gastrointestinal hormones cause rapid c-Met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism.
The Journal of biological chemistry 2006;281(49):37705-19.
2006: Samuel A Mantey; Nieves González; Michael Schumann; Tapas K Pradhan; Lin Shen; David H Coy; Robert T Jensen
Identification of bombesin receptor subtype-specific ligands: effect of N-methyl scanning, truncation, substitution, and evaluation of putative reported selective ligands.
The Journal of pharmacology and experimental therapeutics 2006;319(2):980-9.
2006: Terry W Moody; Li-Chun Sun; Samuel A Mantey; Tapas K Pradhan; L Vienna Mackey; Nieves González; Joseph A Fuselier; David H Coy; Robert T Jensen
In vitro and in vivo antitumor effects of cytotoxic camptothecin-bombesin conjugates are mediated by specific interaction with cellular bombesin receptors.
The Journal of pharmacology and experimental therapeutics 2006;318(3):1265-72.
2005: Hisato Igarashi; Tetsuhide Ito; Samuel A Mantey; Tapas K Pradhan; Wei Hou; David H Coy; Robert T Jensen
Development of simplified vasoactive intestinal peptide analogs with receptor selectivity and stability for human vasoactive intestinal peptide/pituitary adenylate cyclase-activating polypeptide receptors.
The Journal of pharmacology and experimental therapeutics 2005;315(1):370-81.
2005: Terry W Moody; Joseph A Fuselier; David H Coy; Samuel A Mantey; Tapas K Pradhan; Tomoo Nakagawa; Robert T Jensen
Camptothecin-somatostatin conjugates inhibit the growth of small cell lung cancer cells.
Peptides 2005;26(9):1560-6.
2005: Tomoo Nakagawa; Simon J Hocart; Michael Schumann; Jose Tapia; Samuel A Mantey; David H Coy; Kenji Tokita; Tatsuro Katsuno; Robert T Jensen
Identification of key amino acids in the gastrin-releasing peptide receptor (GRPR) responsible for high affinity binding of gastrin-releasing peptide (GRP).
Biochemical pharmacology 2005;69(4):579-93.
2004: Samuel A Mantey; David H Coy; Laurence K Entsuah; Robert T Jensen
Development of bombesin analogs with conformationally restricted amino acid substitutions with enhanced selectivity for the orphan receptor human bombesin receptor subtype 3.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1161-70.
2004: Terry W Moody; Samuel A Mantey; Tapas K Pradhan; Michael Schumann; Tomoo Nakagawa; Alfredo Martinez; Joseph A Fuselier; David H Coy; Robert T Jensen
Development of high affinity camptothecin-bombesin conjugates that have targeted cytotoxicity for bombesin receptor-containing tumor cells.
The Journal of biological chemistry 2004;279(22):23580-9.
2003: Michael Schumann; Tomoo Nakagawa; Samuel A Mantey; Kenji Tokita; David J Venzon; Simon J Hocart; Richard V Benya; Robert T Jensen
Importance of amino acids of the central portion of the second intracellular loop of the gastrin-releasing Peptide receptor for phospholipase C activation, internalization, and chronic down-regulation.
The Journal of pharmacology and experimental therapeutics 2003;307(2):597-607.
2002: Hisato Igarashi; Tetsuhide Ito; Tapas K Pradhan; Samuel A Mantey; Wei Hou; David H Coy; Robert T Jensen
Elucidation of the vasoactive intestinal peptide pharmacophore for VPAC(2) receptors in human and rat and comparison to the pharmacophore for VPAC(1) receptors.
The Journal of pharmacology and experimental therapeutics 2002;303(2):445-60.
2002: Hisato Igarashi; Tetsuhide Ito; Wei Hou; Samuel A Mantey; Tapas K Pradhan; Charles D Ulrich; Simon J Hocart; David H Coy; Robert T Jensen
Elucidation of vasoactive intestinal peptide pharmacophore for VPAC(1) receptors in human, rat, and guinea pig.
The Journal of pharmacology and experimental therapeutics 2002;301(1):37-50.
2001: Tetsuhide Ito; Hisato Igarashi; Tapas K Pradhan; Wei Hou; Samuel A Mantey; J E Taylor; W A Murphy; David H Coy; Robert T Jensen
GI side-effects of a possible therapeutic GRF analogue in monkeys are likely due to VIP receptor agonist activity.
Peptides 2001;22(7):1139-51.
2001: Samuel A Mantey; David H Coy; Tapas K Pradhan; Hisato Igarashi; I M Rizo; L Shen; Wei Hou; Simon J Hocart; Robert T Jensen
Rational design of a peptide agonist that interacts selectively with the orphan receptor, bombesin receptor subtype 3.
The Journal of biological chemistry 2001;276(12):9219-29.
2001: Kenji Tokita; Simon J Hocart; Tatsuro Katsuno; Samuel A Mantey; David H Coy; Robert T Jensen
Tyrosine 220 in the 5th transmembrane domain of the neuromedin B receptor is critical for the high selectivity of the peptoid antagonist PD168368.
The Journal of biological chemistry 2001;276(1):495-504.
2000: Richard V Benya; T Kusui; Tatsuro Katsuno; T Tsuda; Samuel A Mantey; James F Battey; Robert T Jensen
Glycosylation of the gastrin-releasing peptide receptor and its effect on expression, G protein coupling, and receptor modulatory processes.
Molecular pharmacology 2000;58(6):1490-501.
2000: Y Lin; X Jian; Z Lin; Glenn S Kroog; Samuel A Mantey; Robert T Jensen; James F Battey; John K Northup
Two amino acids in the sixth transmembrane segment of the mouse gastrin-releasing peptide receptor are important for receptor activation.
The Journal of pharmacology and experimental therapeutics 2000;294(3):1053-62.
2000: Tetsuhide Ito; Wei Hou; Tatsuro Katsuno; Hisato Igarashi; Tapas K Pradhan; Samuel A Mantey; David H Coy; Robert T Jensen
Rat and guinea pig pancreatic acini possess both VIP(1) and VIP(2) receptors, which mediate enzyme secretion.
American journal of physiology. Gastrointestinal and liver physiology 2000;278(1):G64-74.
1999: RR Ryan; Tatsuro Katsuno; Samuel A Mantey; Tapas K Pradhan; H Christian Weber; David H Coy; James F Battey; Robert T Jensen
Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1202-11.
1999: PJ Donohue; Eduardo Sainz; MA Akeson; Glenn S Kroog; Samuel A Mantey; James F Battey; Robert T Jensen; John K Northup
An aspartate residue at the extracellular boundary of TMII and an arginine residue in TMVII of the gastrin-releasing peptide receptor interact to facilitate heterotrimeric G protein coupling.
Biochemistry 1999;38(29):9366-72.
1999: Tatsuro Katsuno; Tapas K Pradhan; RR Ryan; Samuel A Mantey; Wei Hou; PJ Donohue; MA Akeson; Eliot R Spindel; James F Battey; David H Coy; Robert T Jensen
Pharmacology and cell biology of the bombesin receptor subtype 4 (BB4-R).
Biochemistry 1999;38(22):7307-20.
1998: RR Ryan; H Christian Weber; Samuel A Mantey; Wei Hou; M E Hilburger; Tapas K Pradhan; David H Coy; Robert T Jensen
Pharmacology and intracellular signaling mechanisms of the native human orphan receptor BRS-3 in lung cancer cells.
The Journal of pharmacology and experimental therapeutics 1998;287(1):366-80.
1998: Eduardo Sainz; MA Akeson; Samuel A Mantey; Robert T Jensen; James F Battey
Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor.
The Journal of biological chemistry 1998;273(26):15927-32.
1998: RR Ryan; H Christian Weber; Wei Hou; Eduardo Sainz; Samuel A Mantey; James F Battey; David H Coy; Robert T Jensen
Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3.
The Journal of biological chemistry 1998;273(22):13613-24.
1998: Tapas K Pradhan; Tatsuro Katsuno; J E Taylor; S H Kim; RR Ryan; Samuel A Mantey; PJ Donohue; H Christian Weber; Eduardo Sainz; James F Battey; David H Coy; Robert T Jensen
Identification of a unique ligand which has high affinity for all four bombesin receptor subtypes.
European journal of pharmacology 1998;343(2-3):275-87.
1998: PJ Donohue; Hagit Shapira; Samuel A Mantey; Lori L Hampton; Robert T Jensen; James F Battey
A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system.
Brain research. Molecular brain research 1998;54(1):152-60.
1997: Samuel A Mantey; H Christian Weber; Eduardo Sainz; MA Akeson; RR Ryan; Tapas K Pradhan; Robert Searles; Eliot R Spindel; James F Battey; David H Coy; Robert T Jensen
Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors.
The Journal of biological chemistry 1997;272(41):26062-71.
1997: MA Akeson; Eduardo Sainz; Samuel A Mantey; Robert T Jensen; James F Battey
Identification of four amino acids in the gastrin-releasing peptide receptor that are required for high affinity agonist binding.
The Journal of biological chemistry 1997;272(28):17405-9.
1995: J T Lin; David H Coy; Samuel A Mantey; Robert T Jensen
Comparison of the peptide structural requirements for high affinity interaction with bombesin receptors.
European journal of pharmacology 1995;294(1):55-69.
1995: J T Lin; David H Coy; Samuel A Mantey; Robert T Jensen
Peptide structural requirements for antagonism differ between the two mammalian bombesin receptor subtypes.
The Journal of pharmacology and experimental therapeutics 1995;275(1):285-95.
1995: Z F Gu; Vito D Corleto; Samuel A Mantey; David H Coy; P N Maton; R T Jensi
Somatostatin receptor subtype 3 mediates the inhibitory action of somatostatin on gastric smooth muscle cells.
The American journal of physiology 1995;268(5 Pt 1):G739-48.
1995: Tapas K Pradhan; J M Qian; VE Sutliff; Samuel A Mantey; Robert T Jensen
Identification of CCK-A receptors on chief cells with use of a novel, highly selective ligand.
The American journal of physiology 1995;268(4 Pt 1):G605-12.
1995: C P Felley; J T Lin; Samuel A Mantey; Tapas K Pradhan; Richard V Benya; Robert T Jensen
Bombesin does not stimulate pepsinogen release in isolated gastric chief cells.
Peptides 1995;16(3):383-8.
1994: C P Felley; T M O'Dorisio; B Howe; D H Coy; Samuel A Mantey; Tapas K Pradhan; VE Sutliff; Robert T Jensen
Chief cells possess somatostatin receptors regulated by secretagogues acting through the calcium or cAMP pathway.
The American journal of physiology 1994;266(5 Pt 1):G789-98.
1994: Robert T Jensen; J M Qian; J T Lin; Samuel A Mantey; Joseph R Pisegna; Stephen A Wank
Distinguishing multiple CCK receptor subtypes. Studies with guinea pig chief cells and transfected human CCK receptors.
Annals of the New York Academy of Sciences 1994;713():88-106.
1994: V A Fishbein; David H Coy; S J Hocart; N Y Jiang; J E Mrozinski; Samuel A Mantey; Robert T Jensen
A chimeric VIP-PACAP analogue but not VIP pseudopeptides function as VIP receptor antagonists.
Peptides 1994;15(1):95-100.
1993: M Orbuch; John E Taylor; David H Coy; J E Mrozinski; Samuel A Mantey; James F Battey; J P Moreau; Robert T Jensen
Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues.
Molecular pharmacology 1993;44(4):841-50.
1993: Samuel A Mantey; H Frucht; David H Coy; Robert T Jensen
Characterization of bombesin receptors using a novel, potent, radiolabeled antagonist that distinguishes bombesin receptor subtypes.
Molecular pharmacology 1993;43(5):762-74.
1993: P Hildebrand; J E Mrozinski; Samuel A Mantey; R J Patto; Robert T Jensen
Pancreatic acini possess endothelin receptors whose internalization is regulated by PLC-activating agents.
The American journal of physiology 1993;264(5 Pt 1):G984-93.
1993: L H Wang; Samuel A Mantey; J T Lin; H Frucht; Robert T Jensen
Ligand binding, internalization, degradation and regulation by guanine nucleotides of bombesin receptor subtypes: a comparative study.
Biochimica et biophysica acta 1993;1175(2):232-42.
1992: Richard V Benya; E Wada; James F Battey; Z Fathi; L H Wang; Samuel A Mantey; David H Coy; Robert T Jensen
Neuromedin B receptors retain functional expression when transfected into BALB 3T3 fibroblasts: analysis of binding, kinetics, stoichiometry, modulation by guanine nucleotide-binding proteins, and signal transduction and comparison with natively expressed receptors.
Molecular pharmacology 1992;42(6):1058-68.
1992: C P Felley; J M Qian; Samuel A Mantey; Tapas K Pradhan; Robert T Jensen
Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release.
The American journal of physiology 1992;263(6 Pt 1):G901-7.
1992: L H Wang; James F Battey; E Wada; J T Lin; Samuel A Mantey; David H Coy; Robert T Jensen
Activation of neuromedin B-preferring bombesin receptors on rat glioblastoma C-6 cells increases cellular Ca2+ and phosphoinositides.
The Biochemical journal 1992;286 ( Pt 2)():641-8.
1992: Z F Gu; Tapas K Pradhan; David H Coy; Samuel A Mantey; Nigel W Bunnett; Robert T Jensen; P N Maton
Actions of somatostatins on gastric smooth muscle cells.
The American journal of physiology 1992;262(3 Pt 1):G432-8.
1991: B M Haffar; S J Hocart; David H Coy; Samuel A Mantey; H C Chiang; Robert T Jensen
Reduced peptide bond pseudopeptide analogues of secretin. A new class of secretin receptor antagonists.
The Journal of biological chemistry 1991;266(1):316-22.
1990: T von Schrenck; L H Wang; David H Coy; M L Villanueva; Samuel A Mantey; Robert T Jensen
Potent bombesin receptor antagonists distinguish receptor subtypes.
The American journal of physiology 1990;259(3 Pt 1):G468-73.
1990: L H Wang; David H Coy; John E Taylor; N Y Jiang; S H Kim; J P Moreau; S C Huang; Samuel A Mantey; H Frucht; Robert T Jensen
Desmethionine alkylamide bombesin analogues: a new class of bombesin receptor antagonists with potent antisecretory activity in pancreatic acini and antimitotic activity in Swiss 3T3 cells.
Biochemistry 1990;29(3):616-22.
1990: D H Yu; S C Huang; Stephen A Wank; Samuel A Mantey; J D Gardner; Robert T Jensen
Pancreatic receptors for cholecystokinin: evidence for three receptor classes.
The American journal of physiology 1990;258(1 Pt 1):G86-95.
1989: S C Huang; D H Yu; Stephen A Wank; Samuel A Mantey; J D Gardner; Robert T Jensen
Importance of sulfation of gastrin or cholecystokinin (CCK) on affinity for gastrin and CCK receptors.
Peptides 1989;10(4):785-9.
1989: Z A Saeed; S C Huang; David H Coy; N Y Jiang; P Heinz-Erian; Samuel A Mantey; J D Gardner; Robert T Jensen
Effect of substitutions in position 12 of bombesin on antagonist activity.
Peptides 1989;10(3):597-603.
1989: T Von Schrenck; P Heinz-Erian; Timothy H Moran; Samuel A Mantey; J D Gardner; Robert T Jensen
Neuromedin B receptor in esophagus: evidence for subtypes of bombesin receptors.
The American journal of physiology 1989;256(4 Pt 1):G747-58.
1988: L Zhang; Samuel A Mantey; Robert T Jensen; J D Gardner
An analogue of substance P with broad receptor antagonist activity.
Biochimica et biophysica acta 1988;972(1):37-44.
1988: Robert T Jensen; P Heinz-Erian; Samuel A Mantey; S W Jones; J D Gardner
Characterization of ability of various substance P antagonists to inhibit action of bombesin.
The American journal of physiology 1988;254(6 Pt 1):G883-90.
1988: Robert T Jensen; David H Coy; Z A Saeed; P Heinz-Erian; Samuel A Mantey; J D Gardner
Interaction of bombesin and related peptides with receptors on pancreatic acinar cells.
Annals of the New York Academy of Sciences 1988;547():138-49.