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Pekka Mäntsälä

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Terhi Oja; Tatyana Sandalova; Gunter Schneider; Karel D Klika; Pekka Mäntsälä; Jarmo Niemi; Laila Niiranen; Mikko Metsä-Ketelä
Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Thadée Grocholski; Laurence Humphrey; Pekka Mäntsälä; Jarmo Niemi; Terhi Oja; Mikko Metsä-Ketelä
Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis.
Pekka Patrikainen; Jürgen Rohr; Khaled A Shaaban; Keqian Yang; Keqiang Fan; Pauli Kallio; Karel D Klika; Pekka Mäntsälä; Jarmo Niemi; Mikko Metsä-Ketelä
Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.

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2013: Terhi Oja; Tatyana Sandalova; Gunter Schneider; Karel D Klika; Pekka Mäntsälä; Jarmo Niemi; Laila Niiranen; Mikko Metsä-Ketelä
Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(4):1291-6.
2012: Thadée Grocholski; Laurence Humphrey; Pekka Mäntsälä; Jarmo Niemi; Terhi Oja; Mikko Metsä-Ketelä
Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis.
Journal of bacteriology 2012;194(11):2829-36.
2012: Pekka Patrikainen; Jürgen Rohr; Khaled A Shaaban; Keqian Yang; Keqiang Fan; Pauli Kallio; Karel D Klika; Pekka Mäntsälä; Jarmo Niemi; Mikko Metsä-Ketelä
Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.
Chemistry & biology 2012;19(5):647-55.
2012: Vilja Siitonen; Bastian Blauenburg; Pauli Kallio; Pekka Mäntsälä; Mikko Metsä-Ketelä
Discovery of a two-component monooxygenase SnoaW/SnoaL2 involved in nogalamycin biosynthesis.
Chemistry & biology 2012;19(5):638-46.
2012: Terhi Oja; Jari Sinkkonen; Jarmo Niemi; Laura Appassamy; Karel D Klika; Pekka Mäntsälä; Mikko Metsä-Ketelä
Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(16):6024-9.
2011: Pauli Kallio; Pekka Mäntsälä; Mikko Metsä-Ketelä; Pekka Patrikainen; Jukka-Pekka Suomela; Jarmo Niemi
Flavoprotein hydroxylase PgaE catalyzes two consecutive oxygen-dependent tailoring reactions in angucycline biosynthesis.
Biochemistry 2011;50(24):5535-43.
2010: Thadee Grocholski; Hanna Koskiniemi; Ylva Lindqvist; Pekka Mäntsälä; Jarmo Niemi; Gunter Schneider
Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.
Biochemistry 2010;49(5):934-44.
2009: Ylva Lindqvist; Hanna Koskiniemi; Anna Jansson; Tatyana Sandalova; Robert Schnell; Zhanliang Liu; Pekka Mäntsälä; Jarmo Niemi; Gunter Schneider
Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis.
Journal of molecular biology 2009;393(4):966-77.
2008: Terhi Oja; Kaisa Palmu; Hanna Lehmussola; Outi Leppäranta; Kati Hännikäinen; Jarmo Niemi; Pekka Mäntsälä; Mikko Metsä-Ketelä
Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.
Chemistry & biology 2008;15(10):1046-57.
2008: Pauli Kallio; Zhanliang Liu; Pekka Mäntsälä; Jarmo Niemi; Mikko Metsä-Ketelä
Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C.
Chemistry & biology 2008;15(2):157-66.
2008: Pauli Kallio; Zhanliang Liu; Pekka Mäntsälä; Jarmo Niemi; Mikko Metsä-Ketelä
A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation.
Journal of molecular biology 2008;375(5):1212-21.
2007: Hanna Koskiniemi; Mikko Metsä-Ketelä; Doreen Dobritzsch; Pauli Kallio; Hanna Korhonen; Pekka Mäntsälä; Gunter Schneider; Jarmo Niemi
Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis.
Journal of molecular biology 2007;372(3):633-48.
2007: Kaisa Palmu; Keishi Ishida; Pekka Mäntsälä; Christian Hertweck; Mikko Metsä-Ketelä
Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways.
Chembiochem : a European journal of chemical biology 2007;8(13):1577-84.
2007: Igor Alexeev; Azmiri Sultana; Pekka Mäntsälä; Jarmo Niemi; Gunter Schneider
Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6170-5.
2007: Azmiri Sultana; Igor Alexeev; Inari Kursula; Pekka Mäntsälä; Jarmo Niemi; Gunter Schneider
Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 2):149-59.
2006: Philipp Beinker; Bernhard Lohkamp; Taina Peltonen; Jarmo Niemi; Pekka Mäntsälä; Gunter Schneider
Crystal structures of SnoaL2 and AclR: two putative hydroxylases in the biosynthesis of aromatic polyketide antibiotics.
Journal of molecular biology 2006;359(3):728-40.
2006: Pauli Kallio; Azmiri Sultana; Jarmo Niemi; Pekka Mäntsälä; Gunter Schneider
Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.
Journal of molecular biology 2006;357(1):210-20.
2005: Pekka Rappu; Mari Leppihalme; Pekka Mäntsälä
Mutational analysis of the Bacillus subtilis purA operator site.
Current microbiology 2005;51(5):322-6.
2005: Anna Jansson; Hanna Koskiniemi; Anna Erola; Jessy Wang; Pekka Mäntsälä; Gunter Schneider; Jarmo Niemi
Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor.
The Journal of biological chemistry 2005;280(5):3636-44.
2004: Anna Jansson; Hanna Koskiniemi; Pekka Mäntsälä; Jarmo Niemi; Gunter Schneider
Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products.
The Journal of biological chemistry 2004;279(39):41149-56.
2004: Mikko Metsä-Ketelä; Kristiina Ylihonko; Pekka Mäntsälä
Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.
The Journal of antibiotics 2004;57(8):502-10.
2004: Azmiri Sultana; Pauli Kallio; Anna Jansson; Jarmo Niemi; Pekka Mäntsälä; Gunter Schneider
Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 6):1118-20.
2004: Azmiri Sultana; Pauli Kallio; Anna Jansson; Ji-Shu Wang; Jarmo Niemi; Pekka Mäntsälä; Gunter Schneider
Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation.
The EMBO journal 2004;23(9):1911-21.
2003: Anna Jansson; Jarmo Niemi; Ylva Lindqvist; Pekka Mäntsälä; Gunter Schneider
Crystal structure of aclacinomycin-10-hydroxylase, a S-adenosyl-L-methionine-dependent methyltransferase homolog involved in anthracycline biosynthesis in Streptomyces purpurascens.
Journal of molecular biology 2003;334(2):269-80.
2003: Pekka Rappu; Terhi Pullinen; Pekka Mäntsälä
In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor.
Journal of bacteriology 2003;185(22):6728-31.
2003: Anna Jansson; Jarmo Niemi; Pekka Mäntsälä; Gunter Schneider
Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
The Journal of biological chemistry 2003;278(40):39006-13.
2003: Jaana Kantola; Tero Kunnari; Pekka Mäntsälä; K Ylihonkoa
Expanding the scope of aromatic polyketides by combinatorial biosynthesis.
Combinatorial chemistry & high throughput screening 2003;6(6):501-12.
2003: Anna Jansson; Jarmo Niemi; Pekka Mäntsälä; Gunter Schneider
Crystallization and preliminary X-ray diffraction studies of aclacinomycin-10-methyl esterase and aclacinomycin-10-hydroxylase from Streptomyces purpurascens.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 9):1637-9.
2003: Mikko Metsä-Ketelä; Kaisa Palmu; Tero Kunnari; Kristiina Ylihonko; Pekka Mäntsälä
Engineering anthracycline biosynthesis toward angucyclines.
Antimicrobial agents and chemotherapy 2003;47(4):1291-6.
2002: Kaj Räty; Anne Hautala; Sirke Torkkell; Jaana Kantola; Pekka Mäntsälä; Juha Hakala; Kristiina Ylihonko
Characterization of mutations in aclacinomycin A-non-producing Streptomyces galilaeus strains with altered glycosylation patterns.
Microbiology (Reading, England) 2002;148(Pt 11):3375-84.
2002: Mikko Metsä-Ketelä; Laura Halo; Eveliina Munukka; Juha Hakala; Pekka Mäntsälä; Kristiina Ylihonko
Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species.
Applied and environmental microbiology 2002;68(9):4472-9.
2002: Kaj Räty; Jaana Kantola; Anne Hautala; Juha Hakala; Kristiina Ylihonko; Pekka Mäntsälä
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.
Gene 2002;293(1-2):115-22.
2002: Yulong Wang; Jarmo Niemi; Pekka Mäntsälä
Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products.
FEMS microbiology letters 2002;208(1):117-22.
2001: Sirke Torkkell; Tero Kunnari; Kaisa Palmu; Pekka Mäntsälä; Juha Hakala; Kristiina Ylihonko
The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures.
Molecular genetics and genomics : MGG 2001;266(2):276-88.
2000: Kaj Räty; Tero Kunnari; Juha Hakala; Pekka Mäntsälä; Kristiina Ylihonko
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.
Molecular & general genetics : MGG 2000;264(1-2):164-72.
2000: Yulong Wang; Jarmo Niemi; Kalervo Airas; Kristiina Ylihonko; Juha Hakala; Pekka Mäntsälä
Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens.
Biochimica et biophysica acta 2000;1480(1-2):191-200.
2000: Tero Kunnari; Kristiina Ylihonko; Karel D Klika; Pekka Mäntsälä; Juha Hakala
Hybrid anthracyclines from a genetically engineered Streptomyces galilaeus mutant.
The Journal of organic chemistry 2000;65(10):2851-5.
2000: Sirke Torkkell; Tero Kunnari; Kaisa Palmu; Juha Hakala; Pekka Mäntsälä; Kristiina Ylihonko
Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.
Antimicrobial agents and chemotherapy 2000;44(2):396-9.
2000: Jaana Kantola; Tero Kunnari; Anne Hautala; Juha Hakala; Kristiina Ylihonko; Pekka Mäntsälä
Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp.
Microbiology (Reading, England) 2000;146 ( Pt 1)():155-63.
1999: S Sinha; Pekka Rappu; S C Lange; Pekka Mäntsälä; Howard Zalkin; Janet L Smith
Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13074-9.
1999: Mikko Metsä-Ketelä; Virpi Salo-Zieman; L Halo; Anne Hautala; Juha Hakala; Pekka Mäntsälä; Kristiina Ylihonko
An efficient approach for screening minimal PKS genes from Streptomyces.
FEMS microbiology letters 1999;180(1):1-6.
1999: Tero Kunnari; Kristiina Ylihonko; Anne Hautala; K D Klika; Pekka Mäntsälä; Juha Hakala
Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants.
Bioorganic & medicinal chemistry letters 1999;9(18):2639-42.
1999: Pekka Rappu; Byung Sik Shin; Howard Zalkin; Pekka Mäntsälä
A role for a highly conserved protein of unknown function in regulation of Bacillus subtilis purA by the purine repressor.
Journal of bacteriology 1999;181(12):3810-5.
1999: Jarmo Niemi; Yulong Wang; Kalervo Airas; Kristiina Ylihonko; Juha Hakala; Pekka Mäntsälä
Characterization of aklavinone-11-hydroxylase from Streptomyces purpurascens.
Biochimica et biophysica acta 1999;1430(1):57-64.
1999: T Peltonen; Pekka Mäntsälä
Isolation and characterization of a purC(orf)QLF operon from Lactococcus [correction of Lactobacillus] lactis MG1614.
Molecular & general genetics : MGG 1999;261(1):31-41.
1998: Pauli Ollikka; T Harjunpää; Kaisa Palmu; Pekka Mäntsälä; I Suominen
Oxidation of Crocein Orange G by lignin peroxidase isoenzymes. Kinetics and effect of H2O2.
Applied biochemistry and biotechnology 1998;75(2-3):307-21.
1998: Petri Saviranta; Maria Pajunen; P Jauria; Matti Karp; Kim Pettersson; Pekka Mäntsälä; Timo Lövgren
Engineering the steroid-specificity of an anti-17beta-estradiol Fab by random mutagenesis and competitive phage panning.
Protein engineering 1998;11(2):143-52.
1997: Jaana Kantola; G Blanco; Anne Hautala; Tero Kunnari; Juha Hakala; C Mendez; Kristiina Ylihonko; Pekka Mäntsälä; J Salas
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.
Chemistry & biology 1997;4(10):751-5.
1997: Sirke Torkkell; Kristiina Ylihonko; Juha Hakala; Mikael Skurnik; Pekka Mäntsälä
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.
Molecular & general genetics : MGG 1997;256(2):203-9.
1997: Tero Kunnari; J Tuikkanen; Anne Hautala; Juha Hakala; Kristiina Ylihonko; Pekka Mäntsälä
Isolation and characterization of 8-demethoxy steffimycins and generation of 2,8-demethoxy steffimycins in Streptomyces steffisburgensis by the nogalamycin biosynthesis genes.
The Journal of antibiotics 1997;50(6):496-501.
1997: Maria Pajunen; Petri Saviranta; P Jauria; Matti Karp; Kim Pettersson; Pekka Mäntsälä; T Lovgren
Cloning, sequencing, expression and characterization of three anti-estradiol-17beta Fab fragments.
Biochimica et biophysica acta 1997;1351(1-2):192-202.
1996: Kristiina Ylihonko; Juha Hakala; Tero Kunnari; Pekka Mäntsälä
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.
Microbiology (Reading, England) 1996;142 ( Pt 8)():1965-72.
1996: Kristiina Ylihonko; J Tuikkanen; S Jussila; L Cong; Pekka Mäntsälä
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
Molecular & general genetics : MGG 1996;251(2):113-20.
1995: Jarmo Niemi; Pekka Mäntsälä
Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus.
Journal of bacteriology 1995;177(10):2942-5.
1995: I Suominen; P Meyer; Carola Gabriella Tilgmann; T Glumoff; V Glumoff; Jarmo Käpylä; Pekka Mäntsälä
Effects of signal peptide mutations on processing of Bacillus stearothermophilus alpha-amylase in Escherichia coli.
Microbiology (Reading, England) 1995;141 ( Pt 3)():649-54.
1995: Jukka Hellman; P Lassila; Pekka Mäntsälä
In vitro refolding of cyclomaltodextrin glucanotransferase from cytoplasmic inclusion bodies formed upon expression in Escherichia coli.
Protein expression and purification 1995;6(1):56-62.
1994: Mauno Vihinen; T Peltonen; A Iitiä; I Suominen; Pekka Mäntsälä
C-terminal truncations of a thermostable Bacillus stearothermophilus alpha-amylase.
Protein engineering 1994;7(10):1255-9.
1994: Jarmo Niemi; Pekka Mäntsälä
TRACTOR, a program to locate subclones in a nucleotide sequence using only one sequencing reaction.
Computer applications in the biosciences : CABIOS 1994;10(5):563-6.
1994: Kristiina Ylihonko; Juha Hakala; Jarmo Niemi; J Lundell; Pekka Mäntsälä
Isolation and characterization of aclacinomycin A-non-producing Streptomyces galilaeus (ATCC 31615) mutants.
Microbiology (Reading, England) 1994;140 ( Pt 6)():1359-65.
1994: Jarmo Niemi; Kristiina Ylihonko; Juha Hakala; R Pärssinen; A Kopio; Pekka Mäntsälä
Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus.
Microbiology (Reading, England) 1994;140 ( Pt 6)():1351-8.
1992: Jukka Hellman; S Paavilainen; Pekka Mäntsälä
Expression in E. coli and purification of intracellular proteins by fusion to cyclomaltodextrin glucanotransferase.
Journal of biotechnology 1992;26(2-3):275-88.
1992: J Lampinen; Leeni Koivisto; M Wahlsten; Pekka Mäntsälä; Matti Karp
Expression of luciferase genes from different origins in Bacillus subtilis.
Molecular & general genetics : MGG 1992;232(3):498-504.
1992: Jukka Hellman; Pekka Mäntsälä
Construction of an Escherichia coli export-affinity vector for expression and purification of foreign proteins by fusion to cyclomaltodextrin glucanotransferase.
Journal of biotechnology 1992;23(1):19-34.
1991: P M Palosaari; Mauno Vihinen; Pekka Mäntsälä; Stefan E H Alexson; Taina Pihlajaniemi; J Kalervo Hiltunen
Amino acid sequence similarities of the mitochondrial short chain delta 3, delta 2-enoyl-CoA isomerase and peroxisomal multifunctional delta 3, delta 2-enoyl-CoA isomerase, 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase enzyme in rat liver. The proposed occurrence of isomerization and hydration in the same catalytic domain of the multifunctional enzyme.
The Journal of biological chemistry 1991;266(17):10750-3.
1990: Mauno Vihinen; Pekka Mäntsälä
Characterization of a thermostable Bacillus stearothermophilus alpha-amylase.
Biotechnology and applied biochemistry 1990;12(4):427-35.
1990: Kirsi Huoponen; P Ollikka; M Kälin; Isabelle Walther; Pekka Mäntsälä; Jakob Reiser
Characterization of lignin peroxidase-encoding genes from lignin-degrading basidiomycetes.
Gene 1990;89(1):145-50.
1990: Mauno Vihinen; P Ollikka; J Niskanen; P Meyer; I Suominen; Matti Karp; L Holm; J Knowles; Pekka Mäntsälä
Site-directed mutagenesis of a thermostable alpha-amylase from Bacillus stearothermophilus: putative role of three conserved residues.
Journal of biochemistry 1990;107(2):267-72.
1990: Mauno Vihinen; Pekka Mäntsälä
Conserved residues of liquefying alpha-amylases are concentrated in the vicinity of active site.
Biochemical and biophysical research communications 1990;166(1):61-5.
1989: M Korpela; Pekka Mäntsälä; Esa-Matti Lilius; Matti Karp
Stable-light-emitting Escherichia coli as a biosensor.
Journal of bioluminescence and chemiluminescence 1989;4(1):551-4.
1989: Mauno Vihinen; Pekka Mäntsälä
Microbial amylolytic enzymes.
Critical reviews in biochemistry and molecular biology 1989;24(4):329-418.
1987: I Suominen; Matti Karp; M Lähde; A Kopio; T Glumoff; P Meyer; Pekka Mäntsälä
Extracellular production of cloned alpha-amylase by Escherichia coli.
Gene 1987;61(2):165-76.
1983: I Suominen; Pekka Mäntsälä
Translocation of proteins across membranes.
The International journal of biochemistry 1983;15(5):591-601.
1981: Pekka Mäntsälä; I Suominen
Comparison of periplasmic and membrane associated beta-lactamase.
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 1981;35(8):567-72.