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Marc Adler

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Procedures

X Ray Crystallography

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Chemicals & Drugs

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Tumor Cell Line

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TOP 3
Christopher W West; Marc Adler; Danny Arnaiz; Deborah Chen; Kieu Chu; Giovanna Gualtieri; Elena Ho; Christoph Huwe; David Light; Gary Phillips; Rebecca Pulk; Drew Sukovich; Marc Whitlow; Shendong Yuan; Judi Bryant
Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA).
Richard I Feldman; Bob Mintzer; Daguang Zhu; James M Wu; Sandra L Biroc; Shendong Yuan; Kumar Emayan; Zheng Chang; Deborah Chen; Damian O Arnaiz; Judi Bryant; Xue Snow Ge; Marc Whitlow; Marc Adler; Mark A Polokoff; Wei-Wei Li; Mike Ferrer; Takashi Sato; Jian-Ming Gu; Jun Shen; Jih-Lie Tseng; Harald Dinter; Brad Buckman
Potent triazolothione inhibitor of heat-shock protein-90.
Thomas A Kirkland; Marc Adler; John G Bauman; Ming Chen; Jesper Z Haeggström; Beverly King; Monica J Kochanny; Amy M Liang; Lisa Mendoza; Gary B Phillips; Marjolein Thunnissen; Lan Trinh; Marc Whitlow; Bin Ye; Hong Ye; John Parkinson; William J Guilford
Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.

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All Publications

2009: Christopher W West; Marc Adler; Danny Arnaiz; Deborah Chen; Kieu Chu; Giovanna Gualtieri; Elena Ho; Christoph Huwe; David Light; Gary Phillips; Rebecca Pulk; Drew Sukovich; Marc Whitlow; Shendong Yuan; Judi Bryant
Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA).
Bioorganic & medicinal chemistry letters 2009;19(19):5712-5.
2009: Richard I Feldman; Bob Mintzer; Daguang Zhu; James M Wu; Sandra L Biroc; Shendong Yuan; Kumar Emayan; Zheng Chang; Deborah Chen; Damian O Arnaiz; Judi Bryant; Xue Snow Ge; Marc Whitlow; Marc Adler; Mark A Polokoff; Wei-Wei Li; Mike Ferrer; Takashi Sato; Jian-Ming Gu; Jun Shen; Jih-Lie Tseng; Harald Dinter; Brad Buckman
Potent triazolothione inhibitor of heat-shock protein-90.
Chemical biology & drug design 2009;74(1):43-50.
2008: Thomas A Kirkland; Marc Adler; John G Bauman; Ming Chen; Jesper Z Haeggström; Beverly King; Monica J Kochanny; Amy M Liang; Lisa Mendoza; Gary B Phillips; Marjolein Thunnissen; Lan Trinh; Marc Whitlow; Bin Ye; Hong Ye; John Parkinson; William J Guilford
Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorganic & medicinal chemistry 2008;16(9):4963-83.
2008: Marc Adler; Brad Buckman; Judi Bryant; Zheng Chang; Kieu Chu; Kumar Emayan; Paul Hrvatin; Imadul Islam; John Morser; Drew Sukovich; Christopher West; Shendong Yuan; Marc Whitlow
Structures of potent selective peptide mimetics bound to carboxypeptidase B.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 2):149-57.
2007: Imadul Islam; Greg Brown; Judi Bryant; Paul Hrvatin; Monica J Kochanny; Gary B Phillips; Shendong Yuan; Marc Adler; Marc Whitlow; Dao Lentz; Mark A Polokoff; James Wu; Jun Shen; Janette Walters; Elena Ho; Babu Subramanyam; Daguang Zhu; Richard I Feldman; Damian O Arnaiz
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517.
Bioorganic & medicinal chemistry letters 2007;17(14):3819-25.
2007: Imadul Islam; Judi Bryant; Yuo-Ling Chou; Monica J Kochanny; Wheeseong Lee; Gary B Phillips; Hongyi Yu; Marc Adler; Marc Whitlow; Elena Ho; Dao Lentz; Mark A Polokoff; Babu Subramanyam; James M Wu; Daguang Zhu; Richard I Feldman; Damian O Arnaiz
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.
Bioorganic & medicinal chemistry letters 2007;17(14):3814-8.
2007: Robert G Wei; Marc Adler; David D Davey; Elena Ho; Raju Mohan; Mark A Polokoff; Jih-Lie Tseng; Marc Whitlow; Wei Xu; Shendong Yuan; Gary Phillips
1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.
Bioorganic & medicinal chemistry letters 2007;17(9):2499-504.
2007: Marc Whitlow; Marc Adler; David D Davey; Qinglan Huang; Sunil Koovakkat; John Parkinson; Eric Pham; Mark A Polokoff; Wei Xu; Shendong Yuan; Gary Phillips
The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase.
Bioorganic & medicinal chemistry letters 2007;17(9):2505-8.
2007: David D Davey; Marc Adler; Damian O Arnaiz; Keith Eagen; Shawn Erickson; William J Guilford; Margaret Kenrick; Michael M Morrissey; Mike Ohlmeyer; Gonghua Pan; Vidyadhar M Paradkar; John Parkinson; Mark A Polokoff; Kurt Saionz; Cecile Santos; Babu Subramanyam; Ronald Vergona; Robert G Wei; Marc Whitlow; Bin Ye; Zuchun Spring Zhao; James J Devlin; Gary Phillips
Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.
Journal of medicinal chemistry 2007;50(6):1146-57.
2007: Monica J Kochanny; Marc Adler; Janice Ewing; Brian D Griedel; Elena Ho; Rushad Karanjawala; Wheeseong Lee; Dao Lentz; Amy M Liang; Michael M Morrissey; Gary B Phillips; Joseph Post; Karna L Sacchi; Steven T Sakata; Babu Subramanyam; Ronald Vergona; Janette Walters; Kathy A White; Marc Whitlow; Bin Ye; Zuchun Zhao; Kenneth J Shaw
Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.
Bioorganic & medicinal chemistry 2007;15(5):2127-46.
2007: Imadul Islam; Judi Bryant; Karen May; Raju Mohan; Shendong Yuan; Lorraine Kent; John Morser; Lei Zhao; Ronald Vergona; Kathy White; Marc Adler; Marc Whitlow; Brad Buckman
3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa).
Bioorganic & medicinal chemistry letters 2007;17(5):1349-54.
2005: Jeffrey T Kohrt; Kevin J Filipski; Wayne L Cody; Cuiman Cai; Danette A Dudley; Chad A Van Huis; J Adam Willardsen; Stephen T Rapundalo; Kamlai Saiya-Cork; Robert Leadley; Lakshmi Narasimhan; Erli Zhang; Marc Whitlow; Marc Adler; Kirk McLean; Yuo-Ling Chou; Cecile McKnight; Damian O Arnaiz; Kenneth J Shaw; David R Light; Jeremy J Edmunds
The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex.
Bioorganic & medicinal chemistry letters 2005;15(21):4752-6.
2005: Marc Adler; Judi Bryant; Brad Buckman; Imadul Islam; Brent Larsen; Silke Finster; Lorraine Kent; Karen May; Raju Mohan; Shendong Yuan; Marc Whitlow
Crystal structures of potent thiol-based inhibitors bound to carboxypeptidase B.
Biochemistry 2005;44(26):9339-47.
2005: Richard I Feldman; James M Wu; Mark A Polokoff; Monica J Kochanny; Harald Dinter; Daguang Zhu; Sandra L Biroc; Bruno Alicke; Judi Bryant; Shendong Yuan; Brad Buckman; Dao Lentz; Mike Ferrer; Marc Whitlow; Marc Adler; Silke Finster; Zheng Chang; Damian O Arnaiz
Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.
The Journal of biological chemistry 2005;280(20):19867-74.
2003: Daniel R Studelska; Lynda M McDowell; Marc Adler; Robert D O'Connor; Anil K Mehta; William J Guilford; Jerry L Dallas; Damian O Arnaiz; David R Light; Jacob Schaefer
Conformation of a bound inhibitor of blood coagulant factor Xa.
Biochemistry 2003;42(26):7942-9.
2003: Lynda M McDowell; Margaret A McCarrick; Daniel R Studelska; Robert D O'Connor; David R Light; William J Guilford; Damian O Arnaiz; Marc Adler; Jerry L Dallas; Barbara Poliks; Jacob Schaefer
Human factor Xa bound amidine inhibitor conformation by double rotational-echo double resonance nuclear magnetic resonance and molecular dynamics simulations.
Journal of medicinal chemistry 2003;46(3):359-63.
2002: Marc Adler; Monica J Kochanny; Bin Ye; Galina Rumennik; David R Light; Sara Biancalana; Marc Whitlow
Crystal structures of two potent nonamidine inhibitors bound to factor Xa.
Biochemistry 2002;41(52):15514-23.
2000: Marc Adler; David D Davey; Gary B Phillips; S H Kim; J Jancarik; Galina Rumennik; David R Light; Marc Whitlow
Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa.
Biochemistry 2000;39(41):12534-42.