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Jovita Marcinkeviciene

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Guohua Zhao; Mark S Kirby; Chet Kwon; Jovita Marcinkeviciene; Rex A Parker; James G Robertson; Aiying Wang; Lawrence G Hamann
Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors.
Aiying Wang; Charles Dorso; Lawrence Hamann; Eric Harstad; Lisa Kopcho; Robert Langish; Gregory Locke; Jovita Marcinkeviciene; Petia Shipkova; Mark S Kirby
Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor.
Lorin A Thompson; Jeremy H Toyn; George L Trainor; Changsheng Zheng; Jovita Marcinkeviciene; Jere E Meredith; Jodi K Muckelbauer; Richard E Olson; Jianliang Shi; Andrew J Tebben; Charles F Albright; Donna M Barten; Kenneth M Boy; Catherine R Burton; Daniel M Camac; Andrew P Combs; Robert A Copeland; Carl P Decicco; Andrew C Good; James E Grace; Jason M Guernon; Kimberley A Lentz; Ann Liauw; John E Macor
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.

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2013: Guohua Zhao; Mark S Kirby; Chet Kwon; Jovita Marcinkeviciene; Rex A Parker; James G Robertson; Aiying Wang; Lawrence G Hamann
Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2013;23(6):1622-5.
2012: Aiying Wang; Charles Dorso; Lawrence Hamann; Eric Harstad; Lisa Kopcho; Robert Langish; Gregory Locke; Jovita Marcinkeviciene; Petia Shipkova; Mark S Kirby
Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor.
BMC pharmacology 2012;12():2.
2011: Lorin A Thompson; Jeremy H Toyn; George L Trainor; Changsheng Zheng; Jovita Marcinkeviciene; Jere E Meredith; Jodi K Muckelbauer; Richard E Olson; Jianliang Shi; Andrew J Tebben; Charles F Albright; Donna M Barten; Kenneth M Boy; Catherine R Burton; Daniel M Camac; Andrew P Combs; Robert A Copeland; Carl P Decicco; Andrew C Good; James E Grace; Jason M Guernon; Kimberley A Lentz; Ann Liauw; John E Macor
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(22):6909-15.
2011: Kenneth M Boy; Joanne J Bronson; Catherine R Burton; Daniel M Camac; Andrew C Good; Jason M Guernon; Kimberley A Lentz; John E Macor; Jovita Marcinkeviciene; Jere E Meredith; Jodi K Muckelbauer; Richard E Olson; Jianliang Shi; Andrew J Tebben; Charles F Albright; Donna M Barten; Jeremy H Toyn; Lorin A Thompson
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE).
Bioorganic & medicinal chemistry letters 2011;21(22):6916-24.
2010: Wei Meng; Robert P Brigance; Hannguang J Chao; Aberra Fura; Thomas Harrity; Jovita Marcinkeviciene; Stephen P O'Connor; James K Tamura; Dianlin Xie; Yaqun Zhang; Herbert E Klei; Kevin Kish; Carolyn A Weigelt; Huji Turdi; Aiying Wang; Robert Zahler; Mark S Kirby; Lawrence G Hamann
Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors.
Journal of medicinal chemistry 2010;53(15):5620-8.
2008: Lawrence G Iben; Lisa Kopcho; Jovita Marcinkeviciene; Changsheng Zheng; Lorin A Thompson; Charles F Albright; Jeremy H Toyn
[3H]BMS-599240--a novel tritiated ligand for the characterization of BACE1 inhibitors.
European journal of pharmacology 2008;593(1-3):10-5.
2008: Jere E Meredith; Lorin A Thompson; Jeremy H Toyn; Lawrence Marcin; Donna M Barten; Jovita Marcinkeviciene; Lisa Kopcho; Young Kim; Alan Lin; Valerie Guss; Catherine Burton; Lawrence Iben; Craig Polson; Joe Cantone; Michael Ford; Dieter Drexler; Tracey Fiedler; Kimberley A Lentz; James E Grace; Janet Kolb; Jason Corsa; Maria Pierdomenico; Kelli Jones; Richard E Olson; John E Macor; Charles F Albright
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
The Journal of pharmacology and experimental therapeutics 2008;326(2):502-13.
2008: Greg Locke; Dong Cheng; Mark R Witmer; James K Tamura; Tasir Haque; Robert F Carney; Alan R Rendina; Jovita Marcinkeviciene
Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.
Archives of biochemistry and biophysics 2008;475(1):72-9.
2008: William J Metzler; Joseph Yanchunas; Carolyn Weigelt; Kevin Kish; Herbert E Klei; Dianlin Xie; Yaqun Zhang; Martin Corbett; James K Tamura; Bin He; Lawrence G Hamann; Mark S Kirby; Jovita Marcinkeviciene
Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation.
Protein science : a publication of the Protein Society 2008;17(2):240-50.
2007: Ligaya M Simpkins; Scott A Bolton; Zulan Pi; James C Sutton; Chet Kwon; Guohua Zhao; David R Magnin; David J Augeri; Timur Gungor; David Rotella; Zhong Sun; Yajun Liu; William S Slusarchyk; Jovita Marcinkeviciene; James G Robertson; Aiying Wang; Jeffrey A Robl; Karnail S Atwal; Robert Zahler; Rex A Parker; Mark S Kirby; Lawrence G Hamann
Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(23):6476-80.
2007: Young B Kim; Stephen S Kalinowski; Jovita Marcinkeviciene
A pre-steady state analysis of ligand binding to human glucokinase: evidence for a preexisting equilibrium.
Biochemistry 2007;46(5):1423-31.
2006: David R Magnin; Prakash Taunk; James G Robertson; Aiying Wang; Jovita Marcinkeviciene; Mark S Kirby; Lawrence G Hamann
Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1.
Bioorganic & medicinal chemistry letters 2006;16(6):1731-4.
2006: Young B Kim; Lisa M Kopcho; Mark S Kirby; Lawrence G Hamann; Carolyn A Weigelt; William J Metzler; Jovita Marcinkeviciene
Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118).
Archives of biochemistry and biophysics 2006;445(1):9-18.
2005: Guohua Zhao; Prakash Taunk; David R Magnin; Ligaya M Simpkins; Jeffrey A Robl; Aiying Wang; James G Robertson; Jovita Marcinkeviciene; Doree Sitkoff; Rex A Parker; Mark S Kirby; Lawrence G Hamann
Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(18):3992-5.
2005: David J Augeri; Jeffrey A Robl; David A Betebenner; David R Magnin; Ashish Khanna; James G Robertson; Aiying Wang; Ligaya M Simpkins; Prakash Taunk; Qi Huang; Song-Ping Han; Benoni E Abboa-Offei; Michael Cap; Li Xin; Li Tao; Effie Tozzo; Gustav E Welzel; Donald M Egan; Jovita Marcinkeviciene; Shu Y Chang; Scott A Biller; Mark S Kirby; Rex A Parker; Lawrence G Hamann
Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Journal of medicinal chemistry 2005;48(15):5025-37.
2005: Lisa M Kopcho; Young B Kim; Aiying Wang; Margaret A Liu; Mark S Kirby; Jovita Marcinkeviciene
Probing prime substrate binding sites of human dipeptidyl peptidase-IV using competitive substrate approach.
Archives of biochemistry and biophysics 2005;436(2):367-76.
2003: Larisa Toulokhonova; William J Metzler; Mark R Witmer; Robert Copeland; Jovita Marcinkeviciene
Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism.
The Journal of biological chemistry 2003;278(7):4582-9.
2002: Tasir S Haque; Seifu Tadesse; Jovita Marcinkeviciene; Martin Rogers; Christine F Sizemore; Lisa M Kopcho; Karen M Amsler; Lisa D Ecret; Dong Liang Zhan; Frank Hobbs; Andrew Slee; George L Trainor; Andrew M Stern; Robert Copeland; Andrew P Combs
Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase.
Journal of medicinal chemistry 2002;45(21):4669-78.
2002: Jovita Marcinkeviciene; Lisa M Kopcho; Tao Yang; Robert Copeland; Brian Glass; Andrew P Combs; Nikoo Falahatpisheh; Lorin Thompson
Novel inhibition of porcine pepsin by a substituted piperidine. Preference for one of the enzyme conformers.
The Journal of biological chemistry 2002;277(32):28677-82.
2001: Jovita Marcinkeviciene; Y Luo; N R Graciani; Andrew P Combs; Robert Copeland
Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide.
The Journal of biological chemistry 2001;276(26):23790-4.
2001: Jovita Marcinkeviciene; Wenjun Jiang; Lisa M Kopcho; Greg Locke; Y Luo; Robert Copeland
Enoyl-ACP reductase (FabI) of Haemophilus influenzae: steady-state kinetic mechanism and inhibition by triclosan and hexachlorophene.
Archives of biochemistry and biophysics 2001;390(1):101-8.
2001: WD Mallender; Debra Yager; Luisa Onstead; Michael Nichols; Christopher B Eckman; Kumar Sambamurti; Lisa M Kopcho; Jovita Marcinkeviciene; Robert Copeland; Terrone L Rosenberry
Characterization of recombinant, soluble beta-secretase from an insect cell expression system.
Molecular pharmacology 2001;59(3):619-26.
2000: Robert Copeland; Jovita Marcinkeviciene; Tasir S Haque; Lisa M Kopcho; Wenjun Jiang; K Wang; L D Ecret; Christine F Sizemore; K A Amsler; L Foster; Seifu Tadesse; Andrew P Combs; Andrew M Stern; George L Trainor; Andrew Slee; Martin Rogers; Frank Hobbs
Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis.
The Journal of biological chemistry 2000;275(43):33373-8.
2000: Jovita Marcinkeviciene; Martin Rogers; Lisa M Kopcho; Wenjun Jiang; K Wang; D J Murphy; J Lippy; S Link; Thomas D Y Chung; Frank Hobbs; Tasir S Haque; George L Trainor; Andrew Slee; Andrew M Stern; Robert Copeland
Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones.
Biochemical pharmacology 2000;60(3):339-42.
2000: Wenjun Jiang; Greg Locke; Mark R Harpel; Robert Copeland; Jovita Marcinkeviciene
Role of lys100 in human dihydroorotate dehydrogenase: mutagenesis studies and chemical rescue by external amines.
Biochemistry 2000;39(27):7990-7.
2000: Jovita Marcinkeviciene; Wenjun Jiang; Greg Locke; Lisa M Kopcho; Martin Rogers; Robert Copeland
A second dihydroorotate dehydrogenase (Type A) of the human pathogen Enterococcus faecalis: expression, purification, and steady-state kinetic mechanism.
Archives of biochemistry and biophysics 2000;377(1):178-86.
1999: Jovita Marcinkeviciene; L M Tinney; K H Wang; Martin Rogers; Robert Copeland
Dihydroorotate dehydrogenase B of Enterococcus faecalis. Characterization and insights into chemical mechanism.
Biochemistry 1999;38(40):13129-37.