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Guido Marcucci

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Flavia Pichiorri; Claudia Piovan; Alberto Rocci; Charles L Shapiro; Tiffany Talabere; Stefano Volinia; Jia You; Veronica Balatti; John C Byrd; Luciano Cascione; Jessica Consiglio; Vincenzo Coppola; Luciana De Luca; Michael A Freitas; Pierluigi Gasparini; Jingwen Guan; Craig C Hofmeister; Alessandro Lagana; Guido Marcucci; Gerard Nuovo; Dario Palmieri; Carlo M Croce
In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.
Christine L Phillips; Sebastian Schwind; Teresa Smolarek; Michael Absalon; William Blum; Randall Broun; Stella M Davies; Ramiro Garzon; Guido Marcucci; Richard McMasters; Jun Mo; Jeffrey A Moscow; Maureen O'Brien; John P Perentesis
Low dose decitabine in very high risk relapsed or refractory acute myeloid leukaemia in children and young adults.
Alison Walker; Clara D Bloomfield; Andrew J Carroll; Jessica Kohlschmidt; Guido Marcucci; Krzysztof Mrózek; Mark J Pettenati; Kathleen W Rao; Lisa J Sterling
New recurrent balanced translocations in acute myeloid leukemia and myelodysplastic syndromes: cancer and leukemia group B 8461.

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All Publications

2013: Flavia Pichiorri; Claudia Piovan; Alberto Rocci; Charles L Shapiro; Tiffany Talabere; Stefano Volinia; Jia You; Veronica Balatti; John C Byrd; Luciano Cascione; Jessica Consiglio; Vincenzo Coppola; Luciana De Luca; Michael A Freitas; Pierluigi Gasparini; Jingwen Guan; Craig C Hofmeister; Alessandro Lagana; Guido Marcucci; Gerard Nuovo; Dario Palmieri; Carlo M Croce
In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.
The Journal of experimental medicine 2013;210(5):951-68.
2013: Christine L Phillips; Sebastian Schwind; Teresa Smolarek; Michael Absalon; William Blum; Randall Broun; Stella M Davies; Ramiro Garzon; Guido Marcucci; Richard McMasters; Jun Mo; Jeffrey A Moscow; Maureen O'Brien; John P Perentesis
Low dose decitabine in very high risk relapsed or refractory acute myeloid leukaemia in children and young adults.
British journal of haematology 2013;161(3):406-10.
2013: Alison Walker; Clara D Bloomfield; Andrew J Carroll; Jessica Kohlschmidt; Guido Marcucci; Krzysztof Mrózek; Mark J Pettenati; Kathleen W Rao; Lisa J Sterling
New recurrent balanced translocations in acute myeloid leukemia and myelodysplastic syndromes: cancer and leukemia group B 8461.
Genes, chromosomes & cancer 2013;52(4):385-401.
2013: A Mims; Krzysztof Mrózek; D Perrotti; Ramasamy Santhanam; S Schwind; J Sun; S S Tarighat; A R Walker; C Walker; H Wang; Clara D Bloomfield; William Blum; John C Byrd; Michael A Caligiuri; K K Chan; C-S Chen; A M Dorrance; Ramiro Garzon; P Hoellerbauer; X Huang; S Jacob; L James Lee; Rebecca B Klisovic; Guido Marcucci
Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia.
Leukemia 2013;27(4):871-8.
2013: Gianpiero Di Leva; Marco Galasso; Michela Garofalo; Pierluigi Gasparini; Marilena V Iorio; Meng Li; Guido Marcucci; Kenneth P Nephew; Apollinaire Ngankeu; Gerard Nuovo; Danilo Perrotti; Claudia Piovan; Kimerly A Powell; Santhanam Ramasamy; Cristian Taccioli; Hansjuerg Alder; Laura Anderlucci; Brad Bolon; Anna Bratasz; Daniel Briskin; Douglas G Cheung; Carlo M Croce
Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status.
PLoS genetics 2013;9(3):e1003311.
2013: Yicheng Mao; Guido Marcucci; Xiaokui Mo; John C Byrd; David M Goldenberg; Erin Hertlein; David Jarjoura; Ly James Lee; Robert J Lee; Mitch Phelps; Matthew Stefanovski; William Towns; Georgia Triantafillou; Natarajan Muthusamy
Milatuzumab-conjugated liposomes as targeted dexamethasone carriers for therapeutic delivery in CD74+ B-cell malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(2):347-56.
2013: Sebastian Schwind; Stefano Volinia; Yue-Zhong Wu; Heiko Becker; Clara D Bloomfield; William Blum; Michael A Caligiuri; Andrew J Carroll; John Curfman; Paola Dal Cin; Colin G Edwards; Ann-Kathrin Eisfeld; Pia Hoellerbauer; Jessica Kohlschmidt; Jonathan E Kolitz; Richard A Larson; Kati Maharry; Guido Marcucci; Klaus Metzeler; Krzysztof Mrózek; Deedra Nicolet; Peter Paschka; Mark J Pettenati; Thomas W Prior
inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations.
Blood 2013;121(2):385-91.
2013: Bo Yu; Asha Ramanunni; Xinmei Wang; Li-Yuan Bai; John C Byrd; Kenneth K Chan; Carolyn Cheney; Sarah Elizabeth May Herman; David Jarjoura; Yan Jin; L James Lee; Robert J Lee; Yicheng Mao; Guido Marcucci; Xiaokui Mo; Natarajan Muthusamy
Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia.
Blood 2013;121(1):136-47.
2013: Christopher J Hickey; L James Lee; Kati Maharry; Houda Alachkar; Heiko Becker; Clara D Bloomfield; William Blum; John C Byrd; Michael A Caligiuri; Adrienne Dorrance; Anna Eiring; Todd A Fehniger; Ramiro Garzon; Anjali Mishra; Krzysztof Mrózek; Deedra Nicolet; Danilo Perrotti; Hanna S Radomska; Ramasamy Santhanam; Sebastian Schwind; Ravi Vij; Alison Walker; Susan P Whitman; Lai-Chu Wu; Yue-Zhong Wu; Xi Zhao; Guido Marcucci
Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia.
Blood 2013;121(1):159-69.
2013: Houda Alachkar; John C Byrd; Michael A Caligiuri; Ramiro Garzon; Michael R Grever; Jason G Harb; Christopher J Hickey; A Douglas Kinghorn; David M Lucas; Joshua J Oaks; Li Pan; Danilo Perrotti; Ramasamy Santhanam; Guido Marcucci
Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia.
Journal of hematology & oncology 2013;6():21.
2013: Hongyan Wang; Jiang Wang; Alice Mims; Ramasamy Santhanam; U V Vijaya Saradhi; Sebastian Schwind; Miguel A Villalona-Calero; Alison Walker; Josephine Aimiuwu; William Blum; John C Byrd; Kenneth K Chan; Ping Chen; Ramiro Garzon; Michael R Grever; Rebecca B Klisovic; Zhongfa Liu; Guido Marcucci
In vivo quantification of active decitabine-triphosphate metabolite: a novel pharmacoanalytical endpoint for optimization of hypomethylating therapy in acute myeloid leukemia.
The AAPS journal 2013;15(1):242-9.
2012: Sukhinder K Sandhu; Ramasamy Santhanam; Stefano Volinia; Stefan Costinean; Marco Galasso; Ramiro Garzon; Guido Marcucci; Reid Neinast; Mark R Parthun; Danilo Perrotti; Carlo M Croce
miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(49):20047-52.
2012: Houda Alachkar; Guido Marcucci; Zhiliang Xie; Kenneth K Chan
Determination of cellular uptake and intracellular levels of Cenersen (Aezea(®), EL625), a p53 antisense oligonucleotide in acute myeloid leukemia cells.
Journal of pharmaceutical and biomedical analysis 2012;71():228-32.
2012: Anjali Mishra; Danilo Perrotti; Pierluigi Porcu; Frederick K Racke; Laura J Rush; Gregory H Sams; Ramasamy Santhanam; Deanna Schaefer; Laura Sullivan; Lai-Chu Wu; Yue-Zhong Wu; Xiaojuan Yang; Jianying Zhang; Kenneth K Chan; Jason C Chandler; Douglas P Curphey; Lauren G Falkenberg; Harold Fisk; Ramiro Garzon; Nyla A Heerema; Christopher Hickey; Laura Jaroncyk; Robert J Lee; Shujun Liu; Guido Marcucci; Michael A Caligiuri
Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation.
Cancer cell 2012;22(5):645-55.
2012: Ramiro Garzon; Guido Marcucci
Potential of microRNAs for cancer diagnostics, prognostication and therapy.
Current opinion in oncology 2012;24(6):655-9.
2012: Alison Walker; Guido Marcucci
Molecular prognostic factors in cytogenetically normal acute myeloid leukemia.
Expert review of hematology 2012;5(5):547-58.
2012: Pearlly Yan; Clara D Bloomfield; William Blum; Ralf Bundschuh; John C Byrd; Michael A Caligiuri; John Curfman; David Frankhouser; Ramiro Garzon; Susan Geyer; Michael R Grever; Samson Jacob; Rebecca B Klisovic; Klaus Metzeler; Mark Murphy; Benjamin Rodriguez; Hok-Hei Tam; Michael Trimarchi; Alison Walker; Susan P Whitman; Yue-Zhong Wu; Guido Marcucci
Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia.
Blood 2012;120(12):2466-74.
2012: Jason H Mendler; Klaus Metzeler; Joseph O Moore; Krzysztof Mrózek; Deedra Nicolet; Bayard L Powell; Michael D Radmacher; Sebastian Schwind; Meir Wetzler; Susan P Whitman; Michael A Caligiuri; Andrew J Carroll; Thomas H Carter; Jihane Khalife; Jessica Kohlschmidt; Jonathan E Kolitz; Richard A Larson; Kati Maharry; Guido Marcucci; Maria R Baer; Heiko Becker; Clara D Bloomfield
RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(25):3109-18.
2012: Parvathi Ranganathan; Ramasamy Santhanam; Sharon Shacham; Alison Walker; Xueyan Yu; William Blum; Michael Caligiuri; Carlo M Croce; Michael Kauffman; Rebecca B Klisovic; Guido Marcucci; Caroline Na; Ramiro Garzon
Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia.
Blood 2012;120(9):1765-73.
2012: Yue Zhang; Xinghui Zhao; Nicholas Zorko; Kelsie M Bernot; Michael A Caligiuri; Rajeana M Conway; Susumu Goyama; H Leighton Grimes; Guido Marcucci; James C Mulloy; Yalan Rao; Goro Sashida; Daniel G Tenen; Qian-Fei Wang; Susan P Whitman; David Witte; Zhijian Xiao; Xiaomei Yan; Gang Huang
Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.
Blood 2012;120(5):1118-29.
2012: Nicholas A Zorko; Elshafa H Ahmed; Kelsie M Bernot; Adrienne Dorrance; Nyla A Heerema; Gang Huang; David Jarjoura; Chidimma Kalu; Benjamin H Lee; Charlene Mao; Guido Marcucci; Gabriele G Marcucci; Kathleen K McConnell; Ronald F Siebenaler; Susan P Whitman; Daniel A Yanes; Xiaoli Zhang; Michael A Caligiuri
Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias.
Blood 2012;120(5):1130-6.
2012: Ann-Kathrin Eisfeld; Jonathan E Kolitz; Richard A Larson; Sandya Liyanarachchi; Kati Maharry; Guido Marcucci; Jason H Mendler; Klaus Metzeler; Joseph O Moore; Krzysztof Mrózek; Deedra Nicolet; Ravi Patel; Bayard L Powell; Michael D Radmacher; Sebastian Schwind; Stephan M Tanner; Meir Wetzler; Susan P Whitman; Yue-Zhong Wu; Maria R Baer; Heiko Becker; Michael A Caligiuri; Thomas H Carter; ALBERT DE LA CHAPELLE; Clara D Bloomfield
miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia.
Blood 2012;120(2):249-58.
2012: Susan P Whitman; Yue-Zhong Wu; Maria R Baer; H Becker; Michael A Caligiuri; A J Carroll; T H Carter; J Kohlschmidt; Jonathan E Kolitz; Richard A Larson; Kati Maharry; Guido Marcucci; J H Mendler; Klaus Metzeler; Krzysztof Mrózek; Bayard L Powell; Michael D Radmacher; S Schwind; J Wen; M Wetzler; Clara D Bloomfield
The MLL partial tandem duplication in adults aged 60 years and older with de novo cytogenetically normal acute myeloid leukemia.
Leukemia 2012;26(7):1713-7.
2012: William Blum; John C Byrd; Michael A Caligiuri; Kenneth K Chan; John P Curfman; Steven M Devine; Ann-Kathrin Eisfeld; Celia Garr; Ramiro Garzon; Susan Geyer; Michael R Grever; Samson Jacob; Cheryl Kefauver; Rebecca B Klisovic; Danilo Perrotti; Ramasamy Santhanam; Sebastian Schwind; Somayeh S Tarighat; Alison Walker; Hongyan Wang; Susan Whitman; Clara D Bloomfield; Guido Marcucci
Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia.
Blood 2012;119(25):6025-31.
2012: Hongyan Wang; Zhiliang Xie; John C Byrd; Ping Chen; Michael Chiu; Ming Chiu; Carlo M Croce; Ramiro Garzon; Shujun Liu; Zhongfa Liu; Guido Marcucci; Natarajan Muthusamy; Kenneth K Chan
Synthetic microRNA cassette dosing: pharmacokinetics, tissue distribution and bioactivity.
Molecular pharmaceutics 2012;9(6):1638-44.
2012: Josephine Aimiuwu; William Blum; Ping Chen; Rebecca B Klisovic; Shujun Liu; Guido Marcucci; Alice Mims; Hongyan Wang; Jiang Wang; Zhiliang Xie; Kenneth K Chan
RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia.
Blood 2012;119(22):5229-38.
2012: Parvathi Ranganathan; Sukhinder Sandhu; Ramasamy Santhanam; Arwa Shana'ah; Nicole Stauffer; Patricia A Taylor; Bruce R Blazar; Oliver Broom; John C Byrd; Michael Caligiuri; Luciano Cascione; Stefan Costinean; Carlo M Croce; Steven M Devine; Gregg A Hadley; Mehdi Hamadani; Gang He; Catherine E A Heaphy; Sakari Kauppinen; Alessandro Lagana; Charlene Mao; Guido Marcucci; Caroline Na; Gerard J Nuovo; Susanna Obad; Danilo Perrotti; Ramiro Garzon
Regulation of acute graft-versus-host disease by microRNA-155.
Blood 2012;119(20):4786-97.
2012: Klaus Metzeler; A Walker; Clara D Bloomfield; William Blum; Ramiro Garzon; S Geyer; Rebecca B Klisovic; Guido Marcucci
DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia.
Leukemia 2012;26(5):1106-7.
2012: Ann-Kathrin Eisfeld; Benjamin Leffel; Sandya Liyanarachchi; Kati Maharry; Guido Marcucci; Michael D Radmacher; Sebastian Schwind; Stephan M Tanner; Clara D Bloomfield; Hartmut Döhner; Konstanze Döhner; ALBERT DE LA CHAPELLE
Heritable polymorphism predisposes to high BAALC expression in acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(17):6668-73.
2012: Guido Marcucci; Klaus Metzeler; Joseph O Moore; Krzysztof Mrózek; Deedra Nicolet; Bayard L Powell; Michael D Radmacher; Sebastian Schwind; Meir Wetzler; Susan P Whitman; Yue-Zhong Wu; Michael A Caligiuri; Andrew J Carroll; Thomas H Carter; Jessica Kohlschmidt; Jonathan E Kolitz; Richard A Larson; Kati Maharry; Maria R Baer; Heiko Becker; Clara D Bloomfield
Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(7):742-50.
2012: Michael P Trimarchi; Pearlly Yan; John Curfman; David Frankhouser; Guido Marcucci; Mark Murphy; Benjamin A T Rodriguez; Ralf Bundschuh
Enrichment-based DNA methylation analysis using next-generation sequencing: sample exclusion, estimating changes in global methylation, and the contribution of replicate lanes.
BMC genomics 2012;13 Suppl 8():S6.
2012: Benjamin A T Rodriguez; Sebastian Schwind; Hok-Hei Tam; Michael Trimarchi; Pearlly Yan; Bryan Ball; William Blum; Michael W Y Chan; John Curfman; David Frankhouser; Rita Huang; Hung-Cheng Lai; Guido Marcucci; Mark Murphy; Deval Parikh; Ralf Bundschuh
Methods for high-throughput MethylCap-Seq data analysis.
BMC genomics 2012;13 Suppl 6():S14.
2011: Andrea Kühnl; Guido Marcucci; Martin Neumann; Michael Radmacher; Eckhard Thiel; Clara D Bloomfield; Lars Fransecky; Sandra Heesch; Wolf-Karsten Hofmann; Martin Kaiser; Claudia D Baldus
High expression of IGFBP2 is associated with chemoresistance in adult acute myeloid leukemia.
Leukemia research 2011;35(12):1585-90.
2011: Violaine Havelange; Catherine C E Heaphy; Guido Marcucci; Nicole Stauffer; Stefano Volinia; Michael Andreeff; Carlo M Croce; Ramiro Garzon
Functional implications of microRNAs in acute myeloid leukemia by integrating microRNA and messenger RNA expression profiling.
Cancer 2011;117(20):4696-706.
2011: Heiko Becker; Maria R Baer; Michael A Caligiuri; Andrew J Carroll; Thomas H Carter; Jessica Kohlschmidt; Jonathan E Kolitz; Richard A Larson; Kati Maharry; Guido Marcucci; Klaus Metzeler; Joseph O Moore; Krzysztof Mrózek; Bayard L Powell; Michael D Radmacher; Sebastian Schwind; Meir Wetzler; Susan P Whitman; Yue-Zhong Wu; Clara D Bloomfield
Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
Haematologica 2011;96(10):1488-95.
2011: U V R Vijaya Saradhi; Jiang Wang; Ming Chiu; Joseph M Covey; Michael R Grever; Sneha V Gupta; A Douglas Kinghorn; Yonghua Ling; Zhongfa Liu; David M Lucas; Guido Marcucci; David J Newman; Mitch A Phelps; Kenneth K Chan
Characterization of silvestrol pharmacokinetics in mice using liquid chromatography-tandem mass spectrometry.
The AAPS journal 2011;13(3):347-56.
2011: Alice Mims; Guido Marcucci
Epigenetic priming: the target?
Blood 2011;118(6):1430-1.
2011: Jianhua Yu; Takeki Mitsui; Min Wei; Hsiaoyin Mao; Jonathan P Butchar; Mithun Vinod Shah; Jianying Zhang; Anjali Mishra; Christopher Alvarez-Breckenridge; Xingluo Liu; Shujun Liu; Akihiko Yokohama; Rossana Trotta; Guido Marcucci; Don M Benson; Thomas P Loughran; Susheela Tridandapani; Michael A Caligiuri
NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human.
The Journal of clinical investigation 2011;121(4):1456-70.
2011: Klaus Metzeler; Kati Maharry; Michael D Radmacher; Krzysztof Mrózek; Dean Margeson; Heiko Becker; John Curfman; Kelsi B Holland; Sebastian Schwind; Susan P Whitman; Yue-Zhong Wu; William Blum; Bayard L Powell; Thomas H Carter; Meir Wetzler; Joseph O Moore; Jonathan E Kolitz; Maria R Baer; Andrew J Carroll; Richard A Larson; Michael A Caligiuri; Guido Marcucci; Clara D Bloomfield
TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(10):1373-81.
2011: Ping Chen; Josephine Aimiuwu; Zhiliang Xie; Xiaohui Wei; Shujun Liu; Rebecca B Klisovic; Guido Marcucci; Kenneth K Chan
Biochemical modulation of aracytidine (Ara-C) effects by GTI-2040, a ribonucleotide reductase inhibitor, in K562 human leukemia cells.
The AAPS journal 2011;13(1):131-40.
2011: Guido Marcucci; Torsten Haferlach; Hartmut Döhner
Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(5):475-86.
2011: Guido Marcucci; Krzysztof Mrózek; Michael D Radmacher; Ramiro Garzon; Clara D Bloomfield
The prognostic and functional role of microRNAs in acute myeloid leukemia.
Blood 2011;117(4):1121-9.
2011: Shujun Liu; Francesca Madiai; Kevin V Hackshaw; Carl E Allen; Joseph Carl; Emily Huschart; Chris Karanfilov; Alan Litsky; Christopher J Hickey; Guido Marcucci; Sarandeep Huja; Sudha Agarwal; Jianhua Yu; Michael A Caligiuri; Lai-Chu Wu
The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis.
PloS one 2011;6(3):e17161.
2010: Sebastian Schwind; Kati Maharry; Michael D Radmacher; Krzysztof Mrózek; Kelsi B Holland; Dean Margeson; Susan P Whitman; Christopher Hickey; Heiko Becker; Klaus Metzeler; Peter Paschka; Claudia D Baldus; Shujun Liu; Ramiro Garzon; Bayard L Powell; Jonathan E Kolitz; Andrew J Carroll; Michael A Caligiuri; Richard A Larson; Guido Marcucci; Clara D Bloomfield
Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(36):5257-64.
2010: Sebastian Schwind; Guido Marcucci; Kati Maharry; Michael D Radmacher; Krzysztof Mrózek; Kelsi B Holland; Dean Margeson; Heiko Becker; Susan P Whitman; Yue-Zhong Wu; Klaus Metzeler; Bayard L Powell; Jonathan E Kolitz; Thomas H Carter; Joseph O Moore; Maria R Baer; Andrew J Carroll; Michael A Caligiuri; Richard A Larson; Clara D Bloomfield
BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
Blood 2010;116(25):5660-9.
2010: Hong Li; Yanhui Lu; Longzhu Piao; Jun Wu; Shujun Liu; Guido Marcucci; Manohar Ratnam; Robert J Lee
Targeting human clonogenic acute myelogenous leukemia cells via folate conjugated liposomes combined with receptor modulation by all-trans retinoic acid.
International journal of pharmaceutics 2010;402(1-2):57-63.
2010: Liwen Wang; Sean W Harshman; Shujun Liu; Chen Ren; Hua Xu; Larry Sallans; Michael Grever; John C Byrd; Guido Marcucci; Michael A Freitas
Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia.
Proteomics 2010;10(23):4281-92.
2010: Kenneth K Chan; Zhongfa Liu; Zhiliang Xie; Ming Chiu; Hongyan Wang; Ping Chen; Sarah Dunkerson; Michael Chiu; Shujun Liu; Georgia Triantafillou; Ramiro Garzon; Carlo M Croce; John C Byrd; Natarajan Muthusamy; Guido Marcucci
A novel ultrasensitive hybridization-based ELISA method for 2-methoxyphosphorothiolate microRNAs and its in vitro and in vivo application.
The AAPS journal 2010;12(4):556-68.
2010: Susan P Whitman; Kati Maharry; Michael D Radmacher; Heiko Becker; Krzysztof Mrózek; Dean Margeson; Kelsi B Holland; Yue-Zhong Wu; Sebastian Schwind; Klaus Metzeler; Jing Wen; Maria R Baer; Bayard L Powell; Thomas H Carter; Jonathan E Kolitz; Meir Wetzler; Joseph O Moore; Richard M Stone; Andrew J Carroll; Richard A Larson; Michael A Caligiuri; Guido Marcucci; Clara D Bloomfield
FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
Blood 2010;116(18):3622-6.
2010: Ramiro Garzon; Guido Marcucci; Carlo M Croce
Targeting microRNAs in cancer: rationale, strategies and challenges.
Nature reviews. Drug discovery 2010;9(10):775-89.
2010: Jonathan E Kolitz; Stephen L George; Guido Marcucci; Ravi Vij; Bayard L Powell; Steven Allen; Daniel J DeAngelo; Thomas C Shea; Wendy Stock; Maria R Baer; Vera Hars; Kati Maharry; Eva Hoke; James W Vardiman; Clara D Bloomfield; Richard A Larson
P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808.
Blood 2010;116(9):1413-21.
2010: Heiko Becker; Guido Marcucci; Kati Maharry; Michael D Radmacher; Krzysztof Mrózek; Dean Margeson; Susan P Whitman; Peter Paschka; Kelsi B Holland; Sebastian Schwind; Yue-Zhong Wu; Bayard L Powell; Thomas H Carter; Jonathan E Kolitz; Meir Wetzler; Andrew J Carroll; Maria R Baer; Joseph O Moore; Michael A Caligiuri; Richard A Larson; Clara D Bloomfield
Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
Blood 2010;116(5):788-92.
2010: William Blum; Mitch A Phelps; Rebecca B Klisovic; Darlene M Rozewski; Wenjun Ni; Katie A Albanese; Brad H Rovin; Cheryl Kefauver; Steven M Devine; David M Lucas; Amy Johnson; Larry J Schaaf; John C Byrd; Guido Marcucci; Michael R Grever
Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias.
Haematologica 2010;95(7):1098-105.
2010: Kristie A Blum; Zhongfa Liu; David M Lucas; Ping Chen; Zhiliang Xie; Robert Baiocchi; Donald M Benson; Steven M Devine; Jeffrey Jones; Leslie Andritsos; Joseph Flynn; Christoph Plass; Guido Marcucci; Kenneth K Chan; Michael R Grever; John C Byrd
Phase I trial of low dose decitabine targeting DNA hypermethylation in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: dose-limiting myelosuppression without evidence of DNA hypomethylation.
British journal of haematology 2010;150(2):189-95.
2010: Guido Marcucci; Kati Maharry; Yue-Zhong Wu; Michael D Radmacher; Krzysztof Mrózek; Dean Margeson; Kelsi B Holland; Susan P Whitman; Heiko Becker; Sebastian Schwind; Klaus Metzeler; Bayard L Powell; Thomas H Carter; Jonathan E Kolitz; Meir Wetzler; Andrew J Carroll; Maria R Baer; Michael A Caligiuri; Richard A Larson; Clara D Bloomfield
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(14):2348-55.
2010: Shujun Liu; Lai-Chu Wu; Jiuxia Pang; Ramasamy Santhanam; Sebastian Schwind; Yue-Zhong Wu; Christopher J Hickey; Jianhua Yu; Heiko Becker; Kati Maharry; Michael D Radmacher; Chenglong Li; Susan P Whitman; Anjali Mishra; Nicole Stauffer; Anna Eiring; Roger Briesewitz; Robert A Baiocchi; Kenneth K Chan; Peter Paschka; Michael A Caligiuri; John C Byrd; Carlo M Croce; Clara D Bloomfield; Danilo Perrotti; Ramiro Garzon; Guido Marcucci
Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia.
Cancer cell 2010;17(4):333-47.
2010: Jack Erter; Lapo Alinari; Kamruz Darabi; Metin Gurcan; Ramiro Garzon; Guido Marcucci; Mark A Bechtel; Henry K Wong; Pierluigi Porcu
New targets of therapy in T-cell lymphomas.
Current drug targets 2010;11(4):482-93.
2010: Cyrus Khandanpour; Christian Thiede; Peter J M Valk; Ehssan Sharif-Askari; Holger Nückel; Dietmar Lohmann; Bernhard Horsthemke; Winfried Siffert; Andreas Neubauer; Karl-Heinz Grzeschik; Clara D Bloomfield; Guido Marcucci; Kati Maharry; Marilyn L Slovak; Bert A van der Reijden; Joop H Jansen; Hans K Schackert; Khashayar Afshar; Susanne Schnittger; Justine K Peeters; Frank Kroschinsky; Gerhard Ehninger; Bob Lowenberg; Ulrich Dührsen; Tarik Möröy
A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.
Blood 2010;115(12):2462-72.
2010: Anna Eiring; Jason G Harb; Paolo Neviani; Christopher Garton; Joshua J Oaks; Riccardo Spizzo; Shujun Liu; Sebastian Schwind; Ramasamy Santhanam; Christopher J Hickey; Heiko Becker; Jason C Chandler; Raul Andino; Jorge Cortes; Peter Hokland; Claudia S Huettner; Ravi Bhatia; Denis C Roy; Stephen A Liebhaber; Michael A Caligiuri; Guido Marcucci; Ramiro Garzon; Carlo M Croce; George A Calin; Danilo Perrotti
miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts.
Cell 2010;140(5):652-65.
2010: Heiko Becker; Guido Marcucci; Kati Maharry; Michael D Radmacher; Krzysztof Mrózek; Dean Margeson; Susan P Whitman; Yue-Zhong Wu; Sebastian Schwind; Peter Paschka; Bayard L Powell; Thomas H Carter; Jonathan E Kolitz; Meir Wetzler; Andrew J Carroll; Maria R Baer; Michael A Caligiuri; Richard A Larson; Clara D Bloomfield
Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(4):596-604.
2010: Yan Jin; Shujun Liu; Bo Yu; Sharon Golan; Chee Guan Koh; Jintao Yang; Lenguyen Huynh; Xiaojuan Yang; Jiuxia Pang; Natarajan Muthusamy; Kenneth K Chan; John C Byrd; Yeshayahu Talmon; L James Lee; Robert J Lee; Guido Marcucci
Targeted delivery of antisense oligodeoxynucleotide by transferrin conjugated pH-sensitive lipopolyplex nanoparticles: a novel oligonucleotide-based therapeutic strategy in acute myeloid leukemia.
Molecular pharmaceutics 2010;7(1):196-206.
2010: Jianhua Yu; Hsiaoyin C Mao; Min Wei; Tiffany Hughes; Jianying Zhang; Il-Kyoo Park; Shujun Liu; Susan McClory; Guido Marcucci; Rossana Trotta; Michael A Caligiuri
CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets.
Blood 2010;115(2):274-81.
2010: Chee Guan Koh; Xulang Zhang; Shujun Liu; Sharon Golan; Bo Yu; Xiaojuan Yang; Jingjiao Guan; Yan Jin; Yeshayahu Talmon; Natarajan Muthusamy; Kenneth K Chan; John C Byrd; Robert J Lee; Guido Marcucci; L James Lee
Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing.
Journal of controlled release : official journal of the Controlled Release Society 2010;141(1):62-9.
2010: Wanlop Weecharangsan; Bo Yu; Shujun Liu; Jiu Xia Pang; L James Lee; Guido Marcucci; Robert J Lee
Disulfide-linked liposomes: effective delivery vehicle for Bcl-2 antisense oligodeoxyribonucleotide G3139.
Anticancer research 2010;30(1):31-7.
2009: Ramiro Garzon; Catherine E A Heaphy; Violaine Havelange; Muller Fabbri; Stefano Volinia; Twee Tsao; nicola zanesi; Steven M Kornblau; Guido Marcucci; George A Calin; Michael Andreeff; Carlo M Croce
MicroRNA 29b functions in acute myeloid leukemia.
Blood 2009;114(26):5331-41.
2009: Mehdi Hamadani; William Blum; Gary Phillips; Patrick J Elder; Leslie Andritsos; Craig C Hofmeister; Lynn O'Donnell; Rebecca B Klisovic; Sam Penza; Ramiro Garzon; David Krugh; Thomas Lin; Thomas Bechtel; Don M Benson; John C Byrd; Guido Marcucci; Steven M Devine
Improved nonrelapse mortality and infection rate with lower dose of antithymocyte globulin in patients undergoing reduced-intensity conditioning allogeneic transplantation for hematologic malignancies.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009;15(11):1422-30.
2009: Wanlop Weecharangsan; Bo Yu; Yu Zheng; Shujun Liu; Jiu Xia Pang; L James Lee; Guido Marcucci; Robert J Lee
Efficient delivery of antisense oligodeoxyribonucleotide g3139 by human serum albumin-coated liposomes.
Molecular pharmaceutics 2009;6(6):1848-55.
2009: Jianhua Yu; Min Wei; Hsiaoyin Mao; Jianying Zhang; Tiffany Hughes; Takeki Mitsui; Il-Kyoo Park; Christine Hwang; Shujun Liu; Guido Marcucci; Rossana Trotta; Don M Benson; Michael A Caligiuri
CD94 defines phenotypically and functionally distinct mouse NK cell subsets.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):4968-74.
2009: Zhongfa Liu; Jiejun Wu; Zhiliang Xie; Shujun Liu; Patty Fan-Havard; Hui-Ming (Tim) Huang; Christoph Plass; Guido Marcucci; Kenneth K Chan
Quantification of regional DNA methylation by liquid chromatography/tandem mass spectrometry.
Analytical biochemistry 2009;391(2):106-13.
2009: shih-shih chen; Aparna Raval; Amy J Johnson; Erin Hertlein; Te-Hui Liu; Victor X Jin; Mara H Sherman; Shu-Jun Liu; David W Dawson; Katie E Williams; Mark Lanasa; Sandya Liyanarachchi; Thomas S Lin; Guido Marcucci; yuri pekarsky; Ramana V Davuluri; Carlo M Croce; Denis C Guttridge; Michael A Teitell; John C Byrd; Christoph Plass
Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13433-8.
2009: Guido Marcucci
Molecular markers in acute myeloid leukemia.
Clinical advances in hematology & oncology : H&O 2009;7(7):448-51.
2009: Christian Langer; Guido Marcucci; Kelsi B Holland; Michael D Radmacher; Kati Maharry; Peter Paschka; Susan P Whitman; Krzysztof Mrózek; Claudia D Baldus; Ravi Vij; Bayard L Powell; Andrew J Carroll; Jonathan E Kolitz; Michael A Caligiuri; Richard A Larson; Clara D Bloomfield
Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(19):3198-204.
2009: Guido Marcucci; Krzysztof Mrózek; Michael D Radmacher; Clara D Bloomfield; Carlo M Croce
MicroRNA expression profiling in acute myeloid and chronic lymphocytic leukaemias.
Best practice & research. Clinical haematology 2009;22(2):239-48.
2009: Ping Chen; Zhongfa Liu; Shujun Liu; Zhiliang Xie; Josephine Aimiuwu; Jiuxia Pang; Rebecca B Klisovic; William Blum; Michael R Grever; Guido Marcucci; Kenneth K Chan
A LC-MS/MS method for the analysis of intracellular nucleoside triphosphate levels.
Pharmaceutical research 2009;26(6):1504-15.
2009: Xulang Zhang; Chee Guan Koh; Bo Yu; Shujun Liu; Longzhu Piao; Guido Marcucci; Robert J Lee; L James Lee
Transferrin receptor targeted lipopolyplexes for delivery of antisense oligonucleotide g3139 in a murine k562 xenograft model.
Pharmaceutical research 2009;26(6):1516-24.
2009: Jianhua Yu; Maxim Ershler; Li Yu; Min Wei; Björn Hackanson; Akihiko Yokohama; Takeki Mitsui; Chunhui Liu; Hsiaoyin Mao; Shujun Liu; Zhongfa Liu; Rossana Trotta; Chang-gong liu; Xiuping Liu; Kun Huang; Jan Visser; Guido Marcucci; Christoph Plass; Alexander V Belyavsky; Michael A Caligiuri
TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia.
Blood 2009;113(22):5558-67.
2009: Mehdi Hamadani; Don M Benson; Craig C Hofmeister; Patrick J Elder; William Blum; Pierluigi Porcu; Ramiro Garzon; Kristie A Blum; Thomas S Lin; Guido Marcucci; Steven M Devine
Allogeneic stem cell transplantation for patients with relapsed chemorefractory aggressive non-hodgkin lymphomas.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009;15(5):547-53.
2009: Zhongfa Liu; Shujun Liu; Zhiliang Xie; Ryan E Pavlovicz; Jiejun Wu; Ping Chen; Josephine Aimiuwu; Jiuxia Pang; Deepak Bhasin; Paolo Neviani; James R Fuchs; Christoph Plass; Pui-Kai Li; Chenglong Li; Hui-Ming (Tim) Huang; Lai-Chu Wu; Laura Rush; Hongyan Wang; Danilo Perrotti; Guido Marcucci; Kenneth K Chan
Modulation of DNA methylation by a sesquiterpene lactone parthenolide.
The Journal of pharmacology and experimental therapeutics 2009;329(2):505-14.
2009: Guido Marcucci; Michael D Radmacher; Krzysztof Mrózek; Clara D Bloomfield
MicroRNA expression in acute myeloid leukemia.
Current hematologic malignancy reports 2009;4(2):83-8.
2009: Krzysztof Mrózek; Michael D Radmacher; Clara D Bloomfield; Guido Marcucci
Molecular signatures in acute myeloid leukemia.
Current opinion in hematology 2009;16(2):64-9.
2009: Xiaodan Su; David M Lucas; Liwen Zhang; Hua Xu; Vlad Zabrouskov; Melanie E Davis; Amy R Knapp; Donn C Young; Philip R O Payne; Mark R Parthun; Guido Marcucci; Michael R Grever; John C Byrd; Michael A Freitas
Validation of an LC-MS based approach for profiling histones in chronic lymphocytic leukemia.
Proteomics 2009;9(5):1197-206.
2009: Zhongfa Liu; Zhiliang Xie; William Jones; Ryan E Pavlovicz; Shujun Liu; Jianhua Yu; Pui-Kai Li; Jiayuh Lin; Jame R Fuchs; Guido Marcucci; Chenglong Li; Kenneth K Chan
Curcumin is a potent DNA hypomethylation agent.
Bioorganic & medicinal chemistry letters 2009;19(3):706-9.
2009: Todd A Fehniger; John C Byrd; Guido Marcucci; Camille N Abboud; Cheryl Kefauver; Jacqueline E Payton; Ravi Vij; William Blum
Single-agent lenalidomide induces complete remission of acute myeloid leukemia in patients with isolated trisomy 13.
Blood 2009;113(5):1002-5.
2009: Xiaojuan Yang; Xiaobin Zhao; Mitch A Phelps; Longzhu Piao; Darlene M Rozewski; Qing Liu; L James Lee; Guido Marcucci; Michael R Grever; John C Byrd; James T Dalton; Robert J Lee
A novel liposomal formulation of flavopiridol.
International journal of pharmaceutics 2009;365(1-2):170-4.
2009: Xiaojuan Yang; Chee Guan Koh; Shujun Liu; Xiaogang Pan; Ramasamy Santhanam; Bo Yu; Yong Peng; Jiuxia Pang; Sharon Golan; Yeshayahu Talmon; Yan Jin; Natarajan Muthusamy; John C Byrd; Kenneth K Chan; L James Lee; Guido Marcucci; Robert J Lee
Transferrin receptor-targeted lipid nanoparticles for delivery of an antisense oligodeoxyribonucleotide against Bcl-2.
Molecular pharmaceutics 2009;6(1):221-30.
2008: Rosa Lapalombella; Bo Yu; Georgia Triantafillou; Qing Liu; Jon Butchar; Gerard Lozanski; Asha Ramanunni; Lisa L Smith; William Blum; Leslie Andritsos; Da-Sheng Wang; Amy Lehman; Ching-Shih Chen; Amy J Johnson; Guido Marcucci; Robert J Lee; L James Lee; Susheela Tridandapani; Natarajan Muthusamy; John C Byrd
Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells.
Blood 2008;112(13):5180-9.
2008: Klaus Metzeler; Manuela Hummel; Clara D Bloomfield; Karsten Spiekermann; Jan Braess; Maria-Cristina Sauerland; Achim Heinecke; Michael Radmacher; Guido Marcucci; Susan P Whitman; Kati Maharry; Peter Paschka; Richard A Larson; Wolfgang E Berdel; Thomas Büchner; Bernhard Wörmann; Ulrich Mansmann; Wolfgang Hiddemann; Stefan K Bohlander; Christian Buske
An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia.
Blood 2008;112(10):4193-201.
2008: Krzysztof Mrózek; Guido Marcucci; Peter Paschka; Clara D Bloomfield
Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemia.
Current opinion in oncology 2008;20(6):711-8.
2008: Guido Marcucci; Kati Maharry; Michael D Radmacher; Krzysztof Mrózek; Tamara Vukosavljevic; Peter Paschka; Susan P Whitman; Christian Langer; Claudia D Baldus; Chang-gong liu; Amy S Ruppert; Bayard L Powell; Andrew J Carroll; Michael A Caligiuri; Jonathan E Kolitz; Richard A Larson; Clara D Bloomfield
Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(31):5078-87.
2008: Xiaohui Wei; Guowei Dai; Zhongfa Liu; Hao Cheng; Zhiliang Xie; Rebecca B Klisovic; Guido Marcucci; Kenneth K Chan
Enzyme kinetics of GTI-2040, a phosphorothioate oligonucleotide targeting ribonucleotide reductase.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2227-33.
2008: Andreas Neubauer; Kati Maharry; Krzysztof Mrózek; Christian Thiede; Guido Marcucci; Peter Paschka; Robert J Mayer; Richard A Larson; Edison Liu; Clara D Bloomfield
Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine: a Cancer and Leukemia Group B study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(28):4603-9.
2008: Peter Paschka; Guido Marcucci; Amy S Ruppert; Susan P Whitman; Krzysztof Mrózek; Kati Maharry; Christian Langer; Claudia D Baldus; Weiqiang Zhao; Bayard L Powell; Maria R Baer; Andrew J Carroll; Michael A Caligiuri; Jonathan E Kolitz; Richard A Larson; Clara D Bloomfield
Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(28):4595-602.
2008: Adrienne Dorrance; Shujun Liu; Anita Chong; Benjamin Pulley; David Nemer; Martin Guimond; Weifeng Yuan; Dennis Chang; Susan P Whitman; Guido Marcucci; Michael A Caligiuri
The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele.
Blood 2008;112(6):2508-11.
2008: Susan P Whitman; Björn Hackanson; Sandya Liyanarachchi; Shujun Liu; Laura J Rush; Kati Maharry; Dean Margeson; Ramana V Davuluri; Jing Wen; Tatiana Witte; Li Yu; Chunhui Liu; Clara D Bloomfield; Guido Marcucci; Christoph Plass; Michael A Caligiuri
DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication.
Blood 2008;112(5):2013-6.
2008: Clara D Bloomfield; Guido Marcucci; Konstanze Döhner; Hartmut Döhner
Acute myeloid leukemia. Introduction.
Seminars in oncology 2008;35(4):324-5.
2008: Mehdi Hamadani; Craig C Hofmeister; Buffy Jansak; Gary Phillips; Patrick J Elder; William Blum; Sam Penza; Thomas S Lin; Rebecca Klisovic; Guido Marcucci; Sherif S Farag; Steven M Devine
Addition of infliximab to standard acute graft-versus-host disease prophylaxis following allogeneic peripheral blood cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008;14(7):783-9.
2008: Rebecca B Klisovic; William Blum; Xiaohui Wei; Shujun Liu; Zhongfa Liu; Zhiliang Xie; Tamara Vukosavljevic; Cheryl Kefauver; Lenguyen Huynh; Jiuxia Pang; James A Zwiebel; Steven M Devine; John C Byrd; Michael R Grever; Kenneth Chan; Guido Marcucci
Phase I study of GTI-2040, an antisense to ribonucleotide reductase, in combination with high-dose cytarabine in patients with acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(12):3889-95.
2008: Christian Langer; Michael D Radmacher; Amy S Ruppert; Susan P Whitman; Peter Paschka; Krzysztof Mrózek; Claudia D Baldus; Tamara Vukosavljevic; Chang-gong liu; Mary Elizabeth Ross; Bayard L Powell; Albert de La Chapelle; Jonathan E Kolitz; Richard A Larson; Guido Marcucci; Clara D Bloomfield
High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study.
Blood 2008;111(11):5371-9.
2008: Björn Hackanson; Kristi L Bennett; Romulo M Brena; Jinmai Jiang; Rainer Claus; shih-shih chen; Nadya Blagitko-Dorfs; Kati Maharry; Susan P Whitman; Thomas D Schmittgen; Michael Lübbert; Guido Marcucci; Clara D Bloomfield; Christoph Plass
Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia.
Cancer research 2008;68(9):3142-51.
2008: Guido Marcucci; Michael D Radmacher; Kati Maharry; Krzysztof Mrózek; Amy S Ruppert; Peter Paschka; Tamara Vukosavljevic; Susan P Whitman; Claudia D Baldus; Christian Langer; Chang-gong liu; Andrew J Carroll; Bayard L Powell; Ramiro Garzon; Carlo M Croce; Jonathan E Kolitz; Michael A Caligiuri; Richard A Larson; Clara D Bloomfield
MicroRNA expression in cytogenetically normal acute myeloid leukemia.
The New England journal of medicine 2008;358(18):1919-28.
2008: Rebecca B Klisovic; Wendy Stock; Spero R Cataland; Marko I Klisovic; Shujun Liu; William Blum; Margaret Green; Olatoyosi Odenike; Lucy Godley; Jennifer Vanden Burgt; Emily Van Laar; Michael Cullen; A Robert Macleod; Jeffrey M Besterman; Gregory K Reid; John C Byrd; Guido Marcucci
A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(8):2444-9.
2008: Ramiro Garzon; Stefano Volinia; Chang-gong liu; Cecilia Fernandez-Cymering; Tiziana Palumbo; Flavia Pichiorri; Muller Fabbri; Kevin Coombes; Hansjuerg Alder; Tatsuya Nakamura; Neal Flomenberg; Guido Marcucci; George A Calin; Steven M Kornblau; Andrew Lamb; Clara D Bloomfield; Michael Andreeff; Carlo M Croce
MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.
Blood 2008;111(6):3183-9.
2008: William Blum; Guido Marcucci
New approaches in acute myeloid leukemia.
Best practice & research. Clinical haematology 2008;21(1):29-41.
2008: Shujun Liu; Zhongfa Liu; Zhiliang Xie; Jiuxia Pang; Jianhua Yu; Esther Lehmann; Lenguyen Huynh; Tamara Vukosavljevic; Mitsui Takeki; Rebecca B Klisovic; Robert A Baiocchi; William Blum; Pierluigi Porcu; Ramiro Garzon; John C Byrd; Danilo Perrotti; Michael A Caligiuri; Kenneth K Chan; Lai-Chu Wu; Guido Marcucci
Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.
Blood 2008;111(4):2364-73.
2008: Susan P Whitman; Amy S Ruppert; Michael D Radmacher; Krzysztof Mrózek; Peter Paschka; Christian Langer; Claudia D Baldus; Jing Wen; Frederick Racke; Bayard L Powell; Jonathan E Kolitz; Richard A Larson; Michael A Caligiuri; Guido Marcucci; Clara D Bloomfield
FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications.
Blood 2008;111(3):1552-9.
2008: Rosa Lapalombella; Xiaobin Zhao; Georgia Triantafillou; Bo Yu; Yan Jin; Gerard Lozanski; Carolyn M Cheney; Nyla A Heerema; David Jarjoura; Amy Lehman; L James Lee; Guido Marcucci; Robert J Lee; Michael A Caligiuri; Natarajan Muthusamy; John C Byrd
A novel Raji-Burkitt's lymphoma model for preclinical and mechanistic evaluation of CD52-targeted immunotherapeutic agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):569-78.
2008: Anna Eiring; Paolo Neviani; Ramasamy Santhanam; Joshua J Oaks; Ji Suk Chang; Mario Notari; William Willis; Carlo Gambacorti-Passerini; Stefano Volinia; Guido Marcucci; Michael A Caligiuri; Gustavo W Leone; Danilo Perrotti
Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis.
Blood 2008;111(2):816-28.
2007: Muller Fabbri; Ramiro Garzon; Amelia Cimmino; Zhongfa Liu; nicola zanesi; Elisa Callegari; Shujun Liu; Hansjuerg Alder; Stefan Costinean; Cecilia Fernandez-Cymering; Stefano Volinia; Gulnur Guler; Carl D Morrison; Kenneth K Chan; Guido Marcucci; George A Calin; Kay Huebner; Carlo M Croce
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(40):15805-10.
2007: Paolo Neviani; Ramasamy Santhanam; Joshua J Oaks; Anna Eiring; Mario Notari; Bradley W Blaser; Shujun Liu; Rossana Trotta; Natarajan Muthusamy; Carlo Gambacorti-Passerini; Brian J Druker; Jorge Cortes; Guido Marcucci; Ching-Shih Chen; Nicole M Verrills; Denis C Roy; Michael A Caligiuri; Clara D Bloomfield; John C Byrd; Danilo Perrotti
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.
The Journal of clinical investigation 2007;117(9):2408-21.
2007: Yanhui Lu; Jun Wu; Jianmei Wu; Mefsin Gonit; Xiaojuan Yang; Alice Lee; Guangya Xiang; Hong Li; Shujun Liu; Guido Marcucci; Manohar Ratnam; Robert J Lee
Role of formulation composition in folate receptor-targeted liposomal doxorubicin delivery to acute myelogenous leukemia cells.
Molecular pharmaceutics 2007;4(5):707-12.
2007: Jianhua Yu; Min Wei; Zachary Boyd; Esther B Lehmann; Rossana Trotta; Hsiaoyin Mao; Shujun Liu; Brian Becknell; Michael S Jaung; David Jarjoura; Guido Marcucci; Lai-Chu Wu; Michael A Caligiuri
Transcriptional control of human T-BET expression: the role of Sp1.
European journal of immunology 2007;37(9):2549-61.
2007: William Blum; Rebecca B Klisovic; Björn Hackanson; Zhongfa Liu; Shujun Liu; Hollie Devine; Tamara Vukosavljevic; Lenguyen Huynh; Gerard Lozanski; Cheryl Kefauver; Christoph Plass; Steven M Devine; Nyla A Heerema; Anthony J Murgo; Kenneth K Chan; Michael R Grever; John C Byrd; Guido Marcucci
Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(25):3884-91.
2007: Guido Marcucci; Kati Maharry; Susan P Whitman; Tamara Vukosavljevic; Peter Paschka; Christian Langer; Krzysztof Mrózek; Claudia D Baldus; Andrew J Carroll; Bayard L Powell; Jonathan E Kolitz; Richard A Larson; Clara D Bloomfield
High expression levels of the ETS-related gene, ERG, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(22):3337-43.
2007: Naeem A Ali; James O'Brien; William Blum; John C Byrd; Rebecca B Klisovic; Guido Marcucci; Gary Phillips; Clay B Marsh; Stanley Lemeshow; Michael R Grever
Hyperglycemia in patients with acute myeloid leukemia is associated with increased hospital mortality.
Cancer 2007;110(1):96-102.
2007: Susan P Whitman; Amy S Ruppert; Guido Marcucci; Krzysztof Mrózek; Peter Paschka; Christian Langer; Claudia D Baldus; Jing Wen; Tamara Vukosavljevic; Bayard L Powell; Andrew J Carroll; Jonathan E Kolitz; Richard A Larson; Michael A Caligiuri; Clara D Bloomfield
Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study.
Blood 2007;109(12):5164-7.
2007: Claudia D Baldus; Krzysztof Mrózek; Guido Marcucci; Clara D Bloomfield
Clinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: a concise review.
British journal of haematology 2007;137(5):387-400.
2007: Shujun Liu; Rebecca B Klisovic; Tamara Vukosavljevic; Jianhua Yu; Peter Paschka; Lenguyen Huynh; Jiuxia Pang; Paolo Neviani; Zhongfa Liu; William Blum; Kenneth K Chan; Danilo Perrotti; Guido Marcucci
Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells.
The Journal of pharmacology and experimental therapeutics 2007;321(3):953-60.
2007: Xiaodan Su; Naduparambil K Jacob; Ravindra Amunugama; David M Lucas; Amy R Knapp; Chen Ren; Melanie E Davis; Guido Marcucci; Mark R Parthun; John C Byrd; Richard Fishel; Michael A Freitas
Liquid chromatography mass spectrometry profiling of histones.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;850(1-2):440-54.
2007: Hao Cheng; Zhongfa Liu; William Blum; John C Byrd; Rebecca B Klisovic; Michael R Grever; Guido Marcucci; Kenneth K Chan
Quantification of valproic acid and its metabolite 2-propyl-4-pentenoic acid in human plasma using HPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;850(1-2):206-12.
2007: Xiaodan Su; Liwen Zhang; David M Lucas; Melanie E Davis; Amy R Knapp; Kari B Green-Church; Guido Marcucci; Mark R Parthun; John C Byrd; Michael A Freitas
Histone H4 acetylation dynamics determined by stable isotope labeling with amino acids in cell culture and mass spectrometry.
Analytical biochemistry 2007;363(1):22-34.
2007: Krzysztof Mrózek; Guido Marcucci; Peter Paschka; Susan P Whitman; Clara D Bloomfield
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?
Blood 2007;109(2):431-48.
2007: Chen Ren; Shujun Liu; Kalpana Ghoshal; Pang-Hung Hsu; Samson T Jacob; Guido Marcucci; Michael A Freitas
Simultaneous metabolic labeling of cells with multiple amino acids: Localization and dynamics of histone acetylation and methylation.
Proteomics. Clinical applications 2007;1(1):130-42.
2007: Zhongfa Liu; Shujun Liu; Zhiliang Xie; William Blum; Danilo Perrotti; Peter Paschka; Rebecca B Klisovic; John Byrd; Kenneth K Chan; Guido Marcucci
Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specific and sensitive LC-MS/MS method.
Nucleic acids research 2007;35(5):e31.
2007: Liwen Zhang; Xiaodan Su; Shujun Liu; Amy R Knapp; Mark R Parthun; Guido Marcucci; Michael A Freitas
Histone H4 N-terminal acetylation in Kasumi-1 cells treated with depsipeptide determined by acetic acid-urea polyacrylamide gel electrophoresis, amino acid coded mass tagging, and mass spectrometry.
Journal of proteome research 2007;6(1):81-8.
2006: Zunyan Dai; Shujun Liu; Guido Marcucci; Wolfgang Sadee
5-Aza-2'-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer).
Biochemical and biophysical research communications 2006;351(2):455-61.
2006: Navin Wadehra; Sherif S Farag; Brian J Bolwell; Patrick J Elder; Sam Penza; Matt Kalaycio; Belinda R Avalos; Brad Pohlman; Guido Marcucci; Ronald Sobecks; Thomas Lin; Steven Andrèsen; Edward A Copelan
Long-term outcome of Hodgkin disease patients following high-dose busulfan, etoposide, cyclophosphamide, and autologous stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(12):1343-9.
2006: Adrienne Dorrance; Shujun Liu; Weifeng Yuan; Brian Becknell; Kristy J Arnoczky; Martin Guimond; Matthew P Strout; Lan Feng; Tatsuya Nakamura; Li Yu; Laura J Rush; Michael Weinstein; Gustavo Leone; Lizhao Wu; Amy K Ferketich; Susan P Whitman; Guido Marcucci; Michael A Caligiuri
Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.
The Journal of clinical investigation 2006;116(10):2707-16.
2006: Michael D Radmacher; Guido Marcucci; Amy S Ruppert; Krzysztof Mrózek; Susan P Whitman; James W Vardiman; Peter Paschka; Tamara Vukosavljevic; Claudia D Baldus; Jonathan E Kolitz; Michael A Caligiuri; Richard A Larson; Clara D Bloomfield
Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study.
Blood 2006;108(5):1677-83.
2006: Peter Paschka; Guido Marcucci; Amy S Ruppert; Krzysztof Mrózek; Hankui Chen; Rick Kittles; Tamara Vukosavljevic; Danilo Perrotti; James W Vardiman; Andrew J Carroll; Jonathan E Kolitz; Richard A Larson; Clara D Bloomfield
Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(24):3904-11.
2006: Xiaohui Wei; Guowei Dai; Guido Marcucci; Zhongfa Liu; Dale Hoyt; William Blum; Kenneth K Chan
A specific picomolar hybridization-based ELISA assay for the determination of phosphorothioate oligonucleotides in plasma and cellular matrices.
Pharmaceutical research 2006;23(6):1251-64.
2006: Shih-Jiuan Chiu; Shujun Liu; Danilo Perrotti; Guido Marcucci; Robert J Lee
Efficient delivery of a Bcl-2-specific antisense oligodeoxyribonucleotide (G3139) via transferrin receptor-targeted liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2006;112(2):199-207.
2006: Guido Marcucci
Core binding factor acute myeloid leukemia.
Clinical advances in hematology & oncology : H&O 2006;4(5):339-41.
2006: Jianhua Yu; Min Wei; Brian Becknell; Rossana Trotta; Shujun Liu; Zachary Boyd; Michael S Jaung; Bradley W Blaser; Jin Sun; Don M Benson; Hsiaoyin Mao; Akihiko Yokohama; Darshna Bhatt; Lei Shen; Ramana V Davuluri; Michael Weinstein; Guido Marcucci; Michael A Caligiuri
Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells.
Immunity 2006;24(5):575-90.
2006: Ramiro Garzon; Flavia Pichiorri; Tiziana Palumbo; Rodolfo Iuliano; Amelia Cimmino; Rami I Aqeilan; Stefano Volinia; Darshna Bhatt; Hansjuerg Alder; Guido Marcucci; George A Calin; Chang-gong liu; Clara D Bloomfield; Michael Andreeff; Carlo M Croce
MicroRNA fingerprints during human megakaryocytopoiesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(13):5078-83.
2006: Mario Notari; Paolo Neviani; Ramasamy Santhanam; Bradley W Blaser; Ji Suk Chang; Annamaria Galietta; Anne E Willis; Denis C Roy; Michael A Caligiuri; Guido Marcucci; Danilo Perrotti
A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation.
Blood 2006;107(6):2507-16.
2006: Shih-Jiuan Chiu; Guido Marcucci; Robert J Lee
Efficient delivery of an antisense oligodeoxyribonucleotide formulated in folate receptor-targeted liposomes.
Anticancer research 2006;26(2A):1049-56.
2006: Xiaohui Wei; Guowei Dai; Zhongfa Liu; Hao Cheng; Zhiliang Xie; Guido Marcucci; Kenneth K Chan
Metabolism of GTI-2040, a phosphorothioate oligonucleotide antisense, using ion-pair reversed phase high performance liquid chromatography (HPLC) coupled with electrospray ion-trap mass spectrometry.
The AAPS journal 2006;8(4):E743-55.
2006: Zhongfa Liu; Guido Marcucci; John C Byrd; Michael R Grever; Jim Xiao; Kenneth K Chan
Characterization of decomposition products and preclinical and low dose clinical pharmacokinetics of decitabine (5-aza-2'-deoxycytidine) by a new liquid chromatography/tandem mass spectrometry quantification method.
Rapid communications in mass spectrometry : RCM 2006;20(7):1117-26.
2006: William Blum; Brian J Bolwell; Gary Phillips; Sherif S Farag; Thomas S Lin; Belinda R Avalos; Sam Penza; Guido Marcucci; John C Byrd; Matt Kalaycio; Ronald Sobecks; Brad Pohlman; Stacey Brown; Patrick J Elder; Edward A Copelan
High disease burden is associated with poor outcomes for patients with acute myeloid leukemia not in remission who undergo unrelated donor cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(1):61-7.
2005: Guido Marcucci; Claudia D Baldus; Amy S Ruppert; Michael D Radmacher; Krzysztof Mrózek; Susan P Whitman; Jonathan E Kolitz; Colin G Edwards; James W Vardiman; Bayard L Powell; Maria R Baer; Joseph O Moore; Danilo Perrotti; Michael A Caligiuri; Andrew J Carroll; Richard A Larson; Albert de La Chapelle; Clara D Bloomfield
Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(36):9234-42.
2005: Don M Benson; L O'Donnell; Dave Krugh; T Grady; William Blum; J D Williams; M S Kennedy; Guido Marcucci
Successful management of sudden, massive immune hemolysis following ABO-incompatible allogeneic PBSCT despite methotrexate GvHD prophylaxis.
Bone marrow transplantation 2005;36(12):1111-2.
2005: William Blum; Guido Marcucci
Targeting epigenetic changes in acute myeloid leukemia.
Clinical advances in hematology & oncology : H&O 2005;3(11):855-65, 882.
2005: Paolo Neviani; Ramasamy Santhanam; Rossana Trotta; Mario Notari; Bradley W Blaser; Shujun Liu; Hsiaoyin Mao; Ji Suk Chang; Annamaria Galietta; Ashwin Uttam; Denis C Roy; Mauro Valtieri; Rebecca Bruner-Klisovic; Michael A Caligiuri; Clara D Bloomfield; Guido Marcucci; Danilo Perrotti
The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein.
Cancer cell 2005;8(5):355-68.
2005: Guowei Dai; Xiaohui Wei; Zhongfa Liu; Shujun Liu; Guido Marcucci; Kenneth K Chan
Characterization and quantification of Bcl-2 antisense G3139 and metabolites in plasma and urine by ion-pair reversed phase HPLC coupled with electrospray ion-trap mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;825(2):201-13.
2005: Guido Marcucci; Krzysztof Mrózek; Amy S Ruppert; Kati Maharry; Jonathan E Kolitz; Joseph O Moore; Robert J Mayer; Mark J Pettenati; Bayard L Powell; Colin G Edwards; Lisa J Sterling; James W Vardiman; Charles Alan Schiffer; Andrew J Carroll; Richard A Larson; Clara D Bloomfield
Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(24):5705-17.
2005: Jim J Xiao; Ying Huang; Zunyan Dai; Wolfgang Sadée; Jiyun Chen; Shujun Liu; Guido Marcucci; John Byrd; Joseph M Covey; John Wright; Michael R Grever; Kenneth K Chan
Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines.
The Journal of pharmacology and experimental therapeutics 2005;314(1):467-75.
2005: Susan P Whitman; Shujun Liu; Tamara Vukosavljevic; Laura J Rush; Li Yu; Chunhui Liu; Marko I Klisovic; Kati Maharry; Martin Guimond; Matthew P Strout; Brian Becknell; Adrienne Dorrance; Rebecca B Klisovic; Christoph Plass; Clara D Bloomfield; Guido Marcucci; Michael A Caligiuri
The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy.
Blood 2005;106(1):345-52.
2005: Dino D Klisovic; Marko I Klisovic; David Effron; Shujun Liu; Guido Marcucci; Steven E Katz
Depsipeptide inhibits migration of primary and metastatic uveal melanoma cell lines in vitro: a potential strategy for uveal melanoma.
Melanoma research 2005;15(3):147-53.
2005: Guido Marcucci; Wendy Stock; Guowei Dai; Rebecca B Klisovic; Shujun Liu; Marko I Klisovic; William Blum; Cheryl Kefauver; Dorie A Sher; Margaret Green; Mollie Moran; Kati Maharry; steven novick; Clara D Bloomfield; James A Zwiebel; Richard A Larson; Michael R Grever; Kenneth K Chan; John C Byrd
Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(15):3404-11.
2005: Guowei Dai; Kenneth K Chan; Shujun Liu; Dale Hoyt; Susan P Whitman; Marko I Klisovic; Tiansheng Shen; Michael A Caligiuri; John Byrd; Michael R Grever; Guido Marcucci
Cellular uptake and intracellular levels of the bcl-2 antisense g3139 in cultured cells and treated patients with acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(8):2998-3008.
2005: Sherif S Farag; Brian J Bolwell; Patrick J Elder; Matt Kalaycio; Thomas Lin; Brad Pohlman; Sam Penza; Guido Marcucci; William Blum; Ronald Sobecks; Belinda R Avalos; John C Byrd; Edward A Copelan
High-dose busulfan, cyclophosphamide, and etoposide does not improve outcome of allogeneic stem cell transplantation compared to BuCy2 in patients with acute myeloid leukemia.
Bone marrow transplantation 2005;35(7):653-61.
2005: Jim J Xiao; Amy B Foraker; Peter Swaan; Shujun Liu; Ying Huang; Zunyan Dai; Jiyun Chen; Wolfgang Sadée; John Byrd; Guido Marcucci; Kenneth K Chan
Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.
The Journal of pharmacology and experimental therapeutics 2005;313(1):268-76.
2005: Li Yu; Chunhui Liu; Jeffrey B VanDeusen; Brian Becknell; Zunyan Dai; Yue-Zhong Wu; Aparna Raval; Te-Hui Liu; Wei Ding; Charlene Mao; Shujun Liu; Laura T Smith; Stephen Lee; Laura Rassenti; Guido Marcucci; John Byrd; Michael A Caligiuri; Christoph Plass
Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia.
Nature genetics 2005;37(3):265-74.
2005: Shujun Liu; Tiansheng Shen; Lenguyen Huynh; Marko I Klisovic; Laura J Rush; Jamie L Ford; Jianhua Yu; Brian Becknell; Yu Li; Chunhui Liu; Tamara Vukosavljevic; Susan P Whitman; Kun-Sang Chang; John C Byrd; Danilo Perrotti; Christoph Plass; Guido Marcucci
Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia.
Cancer research 2005;65(4):1277-84.
2005: John C Byrd; Guido Marcucci; Mark R Parthun; Jim J Xiao; Rebecca B Klisovic; Mollie Moran; Thomas S Lin; Shujun Liu; Amy R Sklenar; Melanie E Davis; David M Lucas; Beth Fischer; Roshini Shank; Sooraj L Tejaswi; Philip Binkley; John Wright; Kenneth K Chan; Michael R Grever
A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.
Blood 2005;105(3):959-67.
2005: Guido Marcucci; Krzysztof Mrózek; Clara D Bloomfield
Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics.
Current opinion in hematology 2005;12(1):68-75.
2004: Edward A Copelan; Stacy Hoshaw-Woodard; Patrick J Elder; Sam Penza; Sherif S Farag; Guido Marcucci; Thomas Lin; SA Ezzone; MD Scholl; Thomas Bechtel; Stanley Lemeshow; Belinda R Avalos
Therapy-related myelodysplasia and leukemia occur infrequently following VP-16 priming and autotransplantation without total body irradiation.
Bone marrow transplantation 2004;34(1):85-7.
2004: Guido Marcucci; Krzysztof Mrózek; Amy S Ruppert; Kellie J Archer; Mark J Pettenati; Nyla A Heerema; Andrew J Carroll; Prasad R K Koduru; Jonathan E Kolitz; Lisa J Sterling; Colin G Edwards; John Anastasi; Richard A Larson; Clara D Bloomfield
Abnormal cytogenetics at date of morphologic complete remission predicts short overall and disease-free survival, and higher relapse rate in adult acute myeloid leukemia: results from cancer and leukemia group B study 8461.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(12):2410-8.
2004: Guido Marcucci; Wendy Stock; Guowei Dai; Marko I Klisovic; Kati Maharry; Tiansheng Shen; Shujun Liu; Dorie A Sher; David Lucas; A Zwiebel; Richard A Larson; Michael A Caligiuri; Clara D Bloomfield; Kenneth K Chan; Michael R Grever; John C Byrd
G3139, a BCL-2 antisense oligo-nucleotide, in AML.
Annals of hematology 2004;83 Suppl 1():S93-4.
2004: Clara D Bloomfield; Amy S Ruppert; Krzysztof Mrózek; Jonathan E Kolitz; Joseph O Moore; Robert J Mayer; Colin G Edwards; Lisa J Sterling; James W Vardiman; Andrew J Carroll; Mark J Pettenati; Judith Stamberg; John C Byrd; Guido Marcucci; Richard A Larson
Core binding factor acute myeloid leukemia. Cancer and Leukemia Group B (CALGB) Study 8461.
Annals of hematology 2004;83 Suppl 1():S84-5.
2004: Liwen Zhang; Michael A Freitas; Joseph Wickham; Mark R Parthun; Marko I Klisovic; Guido Marcucci; John C Byrd
Differential expression of histone post-translational modifications in acute myeloid and chronic lymphocytic leukemia determined by high-pressure liquid chromatography and mass spectrometry.
Journal of the American Society for Mass Spectrometry 2004;15(1):77-86.
2003: Herbert Auer; Sandya Lyianarachchi; David Newsom; Marko I Klisovic; Guido Marcucci; Uido Marcucci; Karl Kornacker
Chipping away at the chip bias: RNA degradation in microarray analysis.
Nature genetics 2003;35(4):292-3.
2003: Brian Becknell; Tiansheng Shen; Eman Maghraby; Shinichiro Taya; Kozo Kaibuchi; Michael A Caligiuri; Guido Marcucci
Characterization of leukemia-associated Rho guanine nucleotide exchange factor (LARG) expression during murine development.
Cell and tissue research 2003;314(3):361-6.
2003: Guido Marcucci; Michael A Caligiuri; Clara D Bloomfield
Core binding factor (CBF) acute myeloid leukemia: is molecular monitoring by RT-PCR useful clinically?
European journal of haematology 2003;71(3):143-54.
2003: Claudia D Baldus; Stephan M Tanner; Amy S Ruppert; Susan P Whitman; Kellie J Archer; Guido Marcucci; Michael A Caligiuri; Andrew J Carroll; James W Vardiman; Bayard L Powell; Steven Allen; Joseph O Moore; Richard A Larson; Jonathan E Kolitz; Albert de La Chapelle; Clara D Bloomfield
BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B Study.
Blood 2003;102(5):1613-8.
2003: Jennifer L Aron; Mark R Parthun; Guido Marcucci; Shinichi Kitada; Andrew P Mone; Melanie E Davis; Tiansheng Shen; Timothy Murphy; Joseph Wickham; Chris Kanakry; David M Lucas; John C Reed; Michael R Grever; John C Byrd
Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein.
Blood 2003;102(2):652-8.
2003: Dino D Klisovic; Steven E Katz; David Effron; Marko I Klisovic; Joseph Wickham; Mark R Parthun; Martin Guimond; Guido Marcucci
Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines.
Investigative ophthalmology & visual science 2003;44(6):2390-8.
2003: Guido Marcucci; Danilo Perrotti; Michael A Caligiuri
Understanding the molecular basis of imatinib mesylate therapy in chronic myelogenous leukemia and the related mechanisms of resistance. Commentary re: A. N. Mohamed et al., The effect of imatinib mesylate on patients with Philadelphia chromosome-positive chronic myeloid leukemia with secondary chromosomal aberrations. Clin. Cancer Res., 9: 1333-1337, 2003.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(4):1248-52.
2003: Marko I Klisovic; Eman Maghraby; Mark R Parthun; Martin Guimond; Amy R Sklenar; Susan P Whitman; Kenneth K Chan; T Murphy; J Anon; Kellie J Archer; Laura J Rush; Christoph Plass; Michael R Grever; John C Byrd; Guido Marcucci
Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells.
Leukemia 2003;17(2):350-8.
2003: Guido Marcucci; John C Byrd; Guowei Dai; Marko I Klisovic; Peter J Kourlas; Donn C Young; Spero R Cataland; Diane B Fisher; David Lucas; Kenneth K Chan; Pierluigi Porcu; Zhong-Pin Lin; Sherif F Farag; Stanley R Frankel; James A Zwiebel; Eric H Kraut; Stanley P Balcerzak; Clara D Bloomfield; Michael R Grever; Michael A Caligiuri
Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia.
Blood 2003;101(2):425-32.
2003: Jim J Xiao; John Byrd; Guido Marcucci; Michael R Grever; Kenneth K Chan
Identification of thiols and glutathione conjugates of depsipeptide FK228 (FR901228), a novel histone protein deacetylase inhibitor, in the blood.
Rapid communications in mass spectrometry : RCM 2003;17(8):757-66.
2003: Sherif S Farag; Patrick J Elder; Guido Marcucci; Sam Penza; Ewa Mrozek; A Molina; Thomas Lin; Belinda R Avalos; Edward A Copelan
Radiation-free regimens result in similar outcomes of allogeneic hematopoietic progenitor cell transplantation in patients aged >or=50 years compared to younger adults with low-risk disease.
Bone marrow transplantation 2003;31(2):87-93.
2002: Thomas S Lin; Belinda R Avalos; Sam Penza; Guido Marcucci; Patrick J Elder; Edward A Copelan
Second autologous stem cell transplant for multiply relapsed Hodgkin's disease.
Bone marrow transplantation 2002;29(9):763-7.
2002: Pierluigi Porcu; Sherif S Farag; Guido Marcucci; Spero R Cataland; Melanie S Kennedy; Michael Bissell
Leukocytoreduction for acute leukemia.
Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis 2002;6(1):15-23.
2001: Guido Marcucci; Michael A Caligiuri; Hartmut Döhner; Kellie J Archer; Richard F Schlenk; Konstanze Döhner; Eman Maghraby; Clara D Bloomfield
Quantification of CBFbeta/MYH11 fusion transcript by real time RT-PCR in patients with INV(16) acute myeloid leukemia.
Leukemia 2001;15(7):1072-80.
2001: Krzysztof Mrózek; Thomas W Prior; C Edwards; Guido Marcucci; Andrew J Carroll; Pamela J Snyder; Prasad R K Koduru; Karl S Theil; Mark J Pettenati; Kellie J Archer; Michael A Caligiuri; James W Vardiman; Jonathan E Kolitz; Richard A Larson; Clara D Bloomfield
Comparison of cytogenetic and molecular genetic detection of t(8;21) and inv(16) in a prospective series of adults with de novo acute myeloid leukemia: a Cancer and Leukemia Group B Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(9):2482-92.
2001: Susan P Whitman; Matthew P Strout; Guido Marcucci; Aharon G Freud; L L Culley; N J Zeleznik-Le; Krzysztof Mrózek; Karl S Theil; U R Kees; Clara D Bloomfield; Michael A Caligiuri
The partial nontandem duplication of the MLL (ALL1) gene is a novel rearrangement that generates three distinct fusion transcripts in B-cell acute lymphoblastic leukemia.
Cancer research 2001;61(1):59-63.
1999: Matthew P Strout; Guido Marcucci; Michael A Caligiuri; Clara D Bloomfield
Core-binding factor (CBF) and MLL-associated primary acute myeloid leukemia: biology and clinical implications.
Annals of hematology 1999;78(6):251-64.
1999: Christoph Plass; F Yu; Li Yu; Matthew P Strout; Wa'el El-Rifai; Erkki Elonen; S Knuutila; Guido Marcucci; D C Young; Werner Held; Clara D Bloomfield; Michael A Caligiuri
Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene.
Oncogene 1999;18(20):3159-65.
1998: Guido Marcucci; Kenneth J Livak; Wanli Bi; Matthew P Strout; Clara D Bloomfield; Michael A Caligiuri
Detection of minimal residual disease in patients with AML1/ETO-associated acute myeloid leukemia using a novel quantitative reverse transcription polymerase chain reaction assay.
Leukemia 1998;12(9):1482-9.
1998: Matthew P Strout; Guido Marcucci; Clara D Bloomfield; Michael A Caligiuri
The partial tandem duplication of ALL1 (MLL) is consistently generated by Alu-mediated homologous recombination in acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2390-5.
1998: Guido Marcucci; Matthew P Strout; Clara D Bloomfield; Michael A Caligiuri
Detection of unique ALL1 (MLL) fusion transcripts in normal human bone marrow and blood: distinct origin of normal versus leukemic ALL1 fusion transcripts.
Cancer research 1998;58(4):790-3.
1998: Michael A Caligiuri; Matthew P Strout; David S Lawrence; Diane C Arthur; Maria R Baer; F Yu; S Knuutila; Krzysztof Mrózek; AR Oberkircher; Guido Marcucci; ALBERT DE LA CHAPELLE; Erkki Elonen; A W Block; P N Rao; Geoffrey P Herzig; B L Powell; T Ruutu; Charles Alan Schiffer; Clara D Bloomfield
Rearrangement of ALL1 (MLL) in acute myeloid leukemia with normal cytogenetics.
Cancer research 1998;58(1):55-9.
1997: Guido Marcucci; Michael A Caligiuri; Clara D Bloomfield
Defining the "absence" of the CBFbeta/MYH11 fusion transcript in patients with acute myeloid leukemia and inversion of chromosome 16 to predict long-term complete remission: a call for definitions.
Blood 1997;90(12):5022-5024.