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Patrick Marichal

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Chemicals & Drugs

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Publications

TOP 3
Lieven Meerpoel; Jan Heeres; Leo J J Backx; Louis J E Van der Veken; Rob Hendrickx; David Corens; Alex De Groot; Stef Leurs; Luc Van der Eycken; Johan Weerts; Paul Luyts; Frans Van Gerven; Filip A A Woestenborghs; Andre Van Breda; Michel Oris; Pascal van Dorsselaer; Gustaaf H M Willemsens; Danny Bellens; Patrick Marichal; Hugo F Vanden Bossche; Frank C Odds
Synthesis and in vitro and in vivo antifungal activity of the hydroxy metabolites of saperconazole.
Dimitris Agrafiotis; Simson Alex; Heng Dai; An Derkinderen; Michael A Farnum; Peter Gates; Sergei Izrailev; Edward P Jaeger; Paul Konstant; Albert Leung; Victor S Lobanov; Patrick Marichal; Douglas Martin; Dmitrii N Rassokhin; Maxim Shemanarev; Andrew Skalkin; John Stong; Tom Tabruyn; Marleen Vermeiren; Jackson Wan; Xiang Yang Xu; Xiang Yao
Advanced biological and chemical discovery (ABCD): centralizing discovery knowledge in an inherently decentralized world.
Trevor J Howe; Guy Mahieu; Patrick Marichal; Tom Tabruyn; Pieter Vugts
Data reduction and representation in drug discovery.

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All Publications

2010: Lieven Meerpoel; Jan Heeres; Leo J J Backx; Louis J E Van der Veken; Rob Hendrickx; David Corens; Alex De Groot; Stef Leurs; Luc Van der Eycken; Johan Weerts; Paul Luyts; Frans Van Gerven; Filip A A Woestenborghs; Andre Van Breda; Michel Oris; Pascal van Dorsselaer; Gustaaf H M Willemsens; Danny Bellens; Patrick Marichal; Hugo F Vanden Bossche; Frank C Odds
Synthesis and in vitro and in vivo antifungal activity of the hydroxy metabolites of saperconazole.
ChemMedChem 2010;5(5):757-69.
2007: Dimitris Agrafiotis; Simson Alex; Heng Dai; An Derkinderen; Michael A Farnum; Peter Gates; Sergei Izrailev; Edward P Jaeger; Paul Konstant; Albert Leung; Victor S Lobanov; Patrick Marichal; Douglas Martin; Dmitrii N Rassokhin; Maxim Shemanarev; Andrew Skalkin; John Stong; Tom Tabruyn; Marleen Vermeiren; Jackson Wan; Xiang Yang Xu; Xiang Yao
Advanced biological and chemical discovery (ABCD): centralizing discovery knowledge in an inherently decentralized world.
Journal of chemical information and modeling 2007;47(6):1999-2014.
2007: Trevor J Howe; Guy Mahieu; Patrick Marichal; Tom Tabruyn; Pieter Vugts
Data reduction and representation in drug discovery.
Drug discovery today 2007;12(1-2):45-53.
2005: Lieven Meerpoel; Jef Van Gestel; Frans Van Gerven; Filip A A Woestenborghs; Patrick Marichal; Victor K Sipido; Gilkerson Terence; Roger Nash; David Corens; Ray D Richards
Pyrrolo[1,2-a][1,4]benzodiazepine: a novel class of non-azole anti-dermatophyte anti-fungal agents.
Bioorganic & medicinal chemistry letters 2005;15(14):3453-8.
2005: Lieven Meerpoel; Leo J J Backx; Louis J E Van der Veken; Jan Heeres; David Corens; Alex De Groot; Frank C Odds; Frans Van Gerven; Filip A A Woestenborghs; Andre Van Breda; Michel Oris; Pascal van Dorsselaer; Gustaaf H M Willemsens; Karen J P Vermuyten; Patrick Marichal; Hugo F Vanden Bossche; Jannie Ausma; Marcel Borgers
Synthesis and in vitro and in vivo structure-activity relationships of novel antifungal triazoles for dermatology.
Journal of medicinal chemistry 2005;48(6):2184-93.
2004: Hugo F Vanden Bossche; Jannie Ausma; Hilde Bohets; Karen J P Vermuyten; Gustaaf H M Willemsens; Patrick Marichal; Lieven Meerpoel; Frank C Odds; Marcel Borgers
The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis.
Antimicrobial agents and chemotherapy 2004;48(9):3272-8.
2000: Ashis K Saha; Li Liu; Patrick Marichal; Frank C Odds
Novel antifungals based on 4-substituted imidazole: solid-phase synthesis of substituted aryl sulfonamides towards optimization of in vitro activity.
Bioorganic & medicinal chemistry letters 2000;10(24):2735-9.
2000: Ashis K Saha; Li Liu; Richard Simoneaux; Michael J Kukla; Patrick Marichal; Frank C Odds
Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization.
Bioorganic & medicinal chemistry letters 2000;10(19):2175-8.
1999: Patrick Marichal; J Gorrens; L Laurijssens; Karen J P Vermuyten; C Van Hove; L Le Jeune; Peter Verhasselt; Dominique Sanglard; Marcel Borgers; F C Ramaekers; Frank C Odds; Hugo F Vanden Bossche
Accumulation of 3-ketosteroids induced by itraconazole in azole-resistant clinical Candida albicans isolates.
Antimicrobial agents and chemotherapy 1999;43(11):2663-70.
1999: Patrick Marichal; L Koymans; S Willemsens; D Bellens; Peter Verhasselt; Walter H M L Luyten; Marcel Borgers; F C Ramaekers; Frank C Odds; H V Bossche
Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans.
Microbiology (Reading, England) 1999;145 ( Pt 10)():2701-13.
1999: S Maesaki; Patrick Marichal; Hugo F Vanden Bossche; Dominique Sanglard; Shigeru Kohno
Rhodamine 6G efflux for the detection of CDR1-overexpressing azole-resistant Candida albicans strains.
The Journal of antimicrobial chemotherapy 1999;44(1):27-31.
1998: S Maesaki; Patrick Marichal; M A Hossain; Dominique Sanglard; Hugo F Vanden Bossche; Shigeru Kohno
Synergic effects of tactolimus and azole antifungal agents against azole-resistant Candida albican strains.
The Journal of antimicrobial chemotherapy 1998;42(6):747-53.
1997: Patrick Marichal; Hugo F Vanden Bossche; Frank C Odds; G Nobels; D W Warnock; V Timmerman; Christine Van Broeckhoven; S Fay; P Mose-Larsen
Molecular biological characterization of an azole-resistant Candida glabrata isolate.
Antimicrobial agents and chemotherapy 1997;41(10):2229-37.
1997: Joseph L Wheat; Patrick Marichal; Hugo F Vanden Bossche; Ann Le Monte; Patricia Connolly
Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum.
Antimicrobial agents and chemotherapy 1997;41(2):410-4.
1995: Patrick Marichal; J Gorrens; M C Coene; L Le Jeune; Hugo F Vanden Bossche
Origin of differences in susceptibility of Candida krusei to azole antifungal agents.
Mycoses 1995;38(3-4):111-7.
1995: Patrick Marichal; Hugo F Vanden Bossche
Mechanisms of resistance to azole antifungals.
Acta biochimica Polonica 1995;42(4):509-16.
1994: Hugo F Vanden Bossche; Patrick Marichal; Frank C Odds
Molecular mechanisms of drug resistance in fungi.
Trends in microbiology 1994;2(10):393-400.
1994: Hugo F Vanden Bossche; D W Warnock; Bertrand Dupont; D Kerridge; S Sen Gupta; Luce Improvisi; Patrick Marichal; Frank C Odds; F Provost; Olivier Ronin
Mechanisms and clinical impact of antifungal drug resistance.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1994;32 Suppl 1():189-202.
1993: Hugo F Vanden Bossche; Patrick Marichal; L Le Jeune; M C Coene; J Gorrens; W Cools
Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 1993;37(10):2101-5.
1992: Hugo F Vanden Bossche; Patrick Marichal; Frank C Odds; L Le Jeune; M C Coene
Characterization of an azole-resistant Candida glabrata isolate.
Antimicrobial agents and chemotherapy 1992;36(12):2602-10.
1991: Hugo F Vanden Bossche; Patrick Marichal
Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors.
American journal of obstetrics and gynecology 1991;165(4 Pt 2):1193-9.
1991: Robert Brasseur; Erik Goormaghtigh; Jean-Marie Ruysschaert; P H Duquenoy; Patrick Marichal; Hugo F Vanden Bossche
Lipid-itraconazole interaction in lipid model membranes.
The Journal of pharmacy and pharmacology 1991;43(3):167-71.
1990: Hugo F Vanden Bossche; Patrick Marichal; J Gorrens; M C Coene
Biochemical basis for the activity and selectivity of oral antifungal drugs.
British journal of clinical practice. Supplement 1990;71():41-6.
1990: Hugo F Vanden Bossche; Patrick Marichal; G Willemsens; D Bellens; J Gorrens; I Roels; M C Coene; L Le Jeune; Paul A J Janssen
Saperconazole: a selective inhibitor of the cytochrome P-450-dependent ergosterol synthesis in Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes.
Mycoses 1990;33(7-8):335-52.
1990: Hugo F Vanden Bossche; Patrick Marichal; J Gorrens; D Bellens; HE Moereels; Paul A J Janssen
Mutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals.
Biochemical Society transactions 1990;18(1):56-9.
1989: Hugo F Vanden Bossche; Patrick Marichal; J Gorrens; M C Coene; G Willemsens; D Bellens; I Roels; HE Moereels; Paul A J Janssen
Biochemical approaches to selective antifungal activity. Focus on azole antifungals.
Mycoses 1989;32 Suppl 1():35-52.
1988: Hugo F Vanden Bossche; Patrick Marichal; J Gorrens; Hugo Geerts; Paul A J Janssen
Mode of action studies. Basis for the search of new antifungal drugs.
Annals of the New York Academy of Sciences 1988;544():191-207.
1987: Hugo F Vanden Bossche; G Willemsens; Patrick Marichal
Anti-Candida drugs--the biochemical basis for their activity.
Critical reviews in microbiology 1987;15(1):57-72.
1986: Patrick Marichal; J Gorrens; J Van Cutsem; F Van Gerven; Hugo F Vanden Bossche
Effects of ketoconazole and itraconazole on growth and sterol synthesis in Pityrosporum ovale.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1986;24(6):487-9.
1986: Patrick Marichal; J Gorrens; J Van Cutsem; Hugo F Vanden Bossche
Culture media for the study of the effects of azole derivatives on germ tube formation and hyphal growth of C. albicans.
Mykosen 1986;29(2):76-81.
1985: Patrick Marichal; J Gorrens; Hugo F Vanden Bossche
The action of itraconazole and ketoconazole on growth and sterol synthesis in Aspergillus fumigatus and Aspergillus niger.
Sabouraudia 1985;23(1):13-21.
1983: H Van den Bossche; G Willemsens; W Cools; Patrick Marichal; W Lauwers
Hypothesis on the molecular basis of the antifungal activity of N-substituted imidazoles and triazoles.
Biochemical Society transactions 1983;11(6):665-7.
1982: H Van den Bossche; J M Ruysschaert; F Defrise-Quertain; G Willemsens; F Cornelissen; Patrick Marichal; W Cools; J Van Cutsem
The interaction of miconazole and ketoconazole with lipids.
Biochemical pharmacology 1982;31(16):2609-17.