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Luciana Marinelli

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Elisa Nuti; Elisabetta Orlandini; Silvia Salerno; Salvatore Santamaria; Sabrina Taliani; Kazuhiro Yamamoto; Francesca Casalini; Federico Da Settimo; Valeria La Pietra; Luciana Marinelli; Anna Maria Marini; Hideaki Nagase; Susanna Nencetti; Ettore Novellino; Armando Rossello
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.
Stefania Butini; Giuseppe Campiani; Alice Casagni; Emanuele Gabellieri; Mariateresa Giustiniano; Egeria Guarino; Paul B Huleatt; Valeria La Pietra; Luciana Marinelli; Ettore Novellino; Nicola Relitti; Margherita Brindisi; Sandra Gemma
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.
Stefania Sartini; Francesca Simorini; Sabrina Taliani; Elisabetta Barresi; Sandro Cosconati; Federico Da Settimo; Salvatore Di Maro; Luciana Marinelli; Anna Maria Marini; Ettore Novellino; Silvia Salerno; Concettina La Motta
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies.

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All Publications

2013: Elisa Nuti; Elisabetta Orlandini; Silvia Salerno; Salvatore Santamaria; Sabrina Taliani; Kazuhiro Yamamoto; Francesca Casalini; Federico Da Settimo; Valeria La Pietra; Luciana Marinelli; Anna Maria Marini; Hideaki Nagase; Susanna Nencetti; Ettore Novellino; Armando Rossello
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.
European journal of medicinal chemistry 2013;62():379-94.
2013: Stefania Butini; Giuseppe Campiani; Alice Casagni; Emanuele Gabellieri; Mariateresa Giustiniano; Egeria Guarino; Paul B Huleatt; Valeria La Pietra; Luciana Marinelli; Ettore Novellino; Nicola Relitti; Margherita Brindisi; Sandra Gemma
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.
Bioorganic & medicinal chemistry letters 2013;23(1):85-9.
2012: Stefania Sartini; Francesca Simorini; Sabrina Taliani; Elisabetta Barresi; Sandro Cosconati; Federico Da Settimo; Salvatore Di Maro; Luciana Marinelli; Anna Maria Marini; Ettore Novellino; Silvia Salerno; Concettina La Motta
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies.
Journal of medicinal chemistry 2012;55(23):10523-31.
2012: Sandro Cosconati; Stefano De Tito; Iolanda Fotticchia; Concetta Giancola; Mariateresa Giustiniano; Sara Iachettini; Ilaria Lauri; Luciana Marinelli; Ettore Novellino; Bruno Pagano; Angela Rizzo; Roberta Trotta; Annamaria Biroccio; Antonio Randazzo
Shooting for selective druglike G-quadruplex binders: evidence for telomeric DNA damage and tumor cell death.
Journal of medicinal chemistry 2012;55(22):9785-92.
2012: Salvatore Santamaria; Giovanni Cercignani; Valeria La Pietra; Luciana Marinelli; Ettore Novellino; Elisa Nuti; Armando Rossello
N-O-isopropyl sulfonamido-based hydroxamates: kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors.
Biochemical pharmacology 2012;84(6):813-20.
2012: Lucia Tamborini; Pui E Wong; Michael P Barrett; Sandro Cosconati; Carlo De Micheli; Maria C Iannuzzi; Leonardo Lo Presti; Louise L Major; Luciana Marinelli; Ettore Novellino; Andrea Pinto; Terry K Smith; Paola Conti
Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis.
ChemMedChem 2012;7(9):1623-34.
2012: Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Sandro Cosconati; Salvatore Di Maro; Stefania Gessi; Luciana Marinelli; Stefania Merighi; Allan R Moorman; Romeo Romagnoli; Giulia Saponaro; Katia Varani; Mojgan Aghazadeh Tabrizi; Delia Preti
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A₃ adenosine receptor antagonists.
Journal of medicinal chemistry 2012;55(11):5380-90.
2012: Anna Ramunno; Stefania Sartini; Sara Angiuoli; Sandro Cosconati; Federico Da Settimo; Salvatore Di Maro; Mariateresa Giustiniano; Concettina La Motta; Valeria La Pietra; Vita Maglio; Luciana Marinelli; Ettore Novellino
Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step.
European journal of medicinal chemistry 2012;51():216-26.
2012: Sabrina Taliani; Maria Letizia Trincavelli; Elisabetta Barresi; Sandro Cosconati; Barbara Cosimelli; Simona Daniele; Salvatore Di Maro; Giovanni Greco; Concettina La Motta; Luciana Marinelli; Anna Maria Marini; Claudia Martini; Ettore Novellino; Isabella Pugliesi; Silvia Salerno; Francesca Simorini; Federico Da Settimo
3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists.
Journal of medicinal chemistry 2012;55(4):1490-9.
2012: Vittorio Limongelli; Luciana Marinelli; Laura Mugnaini; Ettore Novellino; Sandro Cosconati; Federico Da Settimo; Concettina La Motta; Stefania Sartini; Michele Parrinello
Sampling protein motion and solvent effect during ligand binding.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(5):1467-72.
2012: Markus Bollinger; Joseph Fanous; Amnon Hoffman; Alexander Bochen; Roman Kolb; Vittorio Limongelli; Wolfgang Lindner; Florian Manzenrieder; Luciana Marinelli; G Moessmer; Stefanie Neubauer; Ettore Novellino; Reinhard Pell; Horst Kessler
Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site.
Journal of medicinal chemistry 2012;55(2):871-82.
2012: Bruno Pagano; Luigi Petraccone; Roberta Trotta; Sandro Cosconati; Stefano De Tito; Francesco Saverio di Leva; Valérie Gabelica; Concetta Giancola; Valeria La Pietra; Ilaria Lauri; Luciana Marinelli; Ettore Novellino; Antonio Randazzo
State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders.
Current pharmaceutical design 2012;18(14):1880-99.
2012: Barbara Cosimelli; Luciana Marinelli; Ettore Novellino; Sandro Cosconati; Giovanni Greco
From the pharmacophore to the homology model of the benzodiazepine receptor: the indolyglyoxylamides affair.
Current topics in medicinal chemistry 2012;12(4):321-32.
2012: Valeria La Pietra; Concettina La Motta; Luciana Marinelli; Matteo Morelli; Hideaki Nagase; Francesca Casalini; Sandro Cosconati; Federico Da Settimo; Francesco Saverio Di Leva; Elisa Nuti; Isabella Pugliesi; Armando Rossello; Salvatore Santamaria; Sabrina Taliani; Robert Visse; Ettore Novellino
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization.
European journal of medicinal chemistry 2012;47(1):143-52.
2011: Oliver Demmer; Ingrid Dijkgraaf; Eleni Gourni; Luciana Marinelli; Udo Schumacher; Hans-Jürgen Wester; Sandro Cosconati; Horst Kessler
Design, synthesis, and functionalization of dimeric peptides targeting chemokine receptor CXCR4.
Journal of medicinal chemistry 2011;54(21):7648-62.
2011: Carlos Mas-Moruno; Ettore Novellino; Luciana Marinelli; Johannes G Beck; Sandro Cosconati; Lucas Doedens; Andreas O Frank; Horst Kessler
Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation.
Angewandte Chemie (International ed. in English) 2011;50(40):9496-500.
2011: Maurizio Anzini; Laura Betti; Stefano Alcaro; Carlo Braile; Andrea Cappelli; Simona Daniele; Carla Ghelardini; Gino Giannaccini; Gianluca Giorgi; Vittorio Limongelli; Antonio Lucacchini; Luciana Marinelli; Claudia Martini; Maria Paola Mascia; Ettore Novellino; Francesco Ortuso; Salvatore Valenti; Salvatore Vomero; Lorenzo Di Cesare Mannelli; Giovanni Biggio
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds.
Journal of medicinal chemistry 2011;54(16):5694-711.
2011: Roberta Trotta; Maria R Conte; Sandro Cosconati; Stefano De Tito; Valeria La Pietra; Ilaria Lauri; Luciana Marinelli; Luigi Martino; Luciano Mayol; Ettore Novellino; Antonio Randazzo
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies.
Biochimie 2011;93(8):1280-7.
2011: Pier Giovanni Baraldi; Stefania Baraldi; Sandro Cosconati; Salvatore Di Maro; Luciana Marinelli; Allan R Moorman; Ettore Novellino; Delia Preti; LUISA-CARLOTA LÓPEZ-CARA; Giulia Saponaro; Mojgan Aghazadeh Tabrizi; Katia Varani; Abdel Naser Zaid; Pier Andrea Borea
New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2011;54(14):5205-20.
2011: Rosaria Ottanà; Rosanna Maccari; Marco Giglio; Antonella Del Corso; Mario Cappiello; Umberto Mura; Sandro Cosconati; Luciana Marinelli; Ettore Novellino; Stefania Sartini; Concettina La Motta; Federico Da Settimo
Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications.
European journal of medicinal chemistry 2011;46(7):2797-806.
2011: Elisa Nuti; Francesca Casalini; Salvatore Santamaria; Pamela Gabelloni; Sara Bendinelli; Eleonora Da Pozzo; Barbara Costa; Luciana Marinelli; Valeria La Pietra; Ettore Novellino; M Margarida Bernardo; Rafael Fridman; Federico Da Settimo; Claudia Martini; Armando Rossello
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.
European journal of medicinal chemistry 2011;46(7):2617-29.
2010: Andreas O Frank; Elke Otto; Carlos Mas-Moruno; Herbert B Schiller; Luciana Marinelli; Sandro Cosconati; Alexander Bochen; Dörte Vossmeyer; Grit Zahn; Roland Stragies; Ettore Novellino; Horst Kessler
Conformational control of integrin-subtype selectivity in isoDGR peptide motifs: a biological switch.
Angewandte Chemie (International ed. in English) 2010;49(48):9278-81.
2010: Sabrina Taliani; Concettina La Motta; Laura Mugnaini; Francesca Simorini; Silvia Salerno; Anna Maria Marini; Federico Da Settimo; Sandro Cosconati; Barbara Cosimelli; Giovanni Greco; Vittorio Limongelli; Luciana Marinelli; Ettore Novellino; Osele Ciampi; Simona Daniele; Maria Letizia Trincavelli; Claudia Martini
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.
Journal of medicinal chemistry 2010;53(10):3954-63.
2010: Sandro Cosconati; Luciana Marinelli; Roberta Trotta; Ada Virno; Stefano De Tito; Romeo Romagnoli; Bruno Pagano; Vittorio Limongelli; Concetta Giancola; Pier Giovanni Baraldi; Luciano Mayol; Ettore Novellino; Antonio Randazzo
Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle.
Journal of the American Chemical Society 2010;132(18):6425-33.
2010: Elisa Nuti; Francesca Casalini; Stanislava I Avramova; Salvatore Santamaria; Marina Fabbi; Silvano Ferrini; Luciana Marinelli; Valeria La Pietra; Vittorio Limongelli; Ettore Novellino; Giovanni Cercignani; Elisabetta Orlandini; Susanna Nencetti; Armando Rossello
Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.
Journal of medicinal chemistry 2010;53(6):2622-35.
2009: Sandro Cosconati; Luciana Marinelli; Roberta Trotta; Ada Virno; Luciano Mayol; Ettore Novellino; Arthur J Olson; Antonio Randazzo
Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders.
Journal of the American Chemical Society 2009;131(45):16336-7.
2009: Sandro Cosconati; Luciana Marinelli; Concettina La Motta; Stefania Sartini; Federico Da Settimo; Arthur J Olson; Ettore Novellino
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening.
Journal of medicinal chemistry 2009;52(18):5578-81.
2009: Elisa Nuti; Francesca Casalini; Stanislava I Avramova; Salvatore Santamaria; Giovanni Cercignani; Luciana Marinelli; Valeria La Pietra; Ettore Novellino; Elisabetta Orlandini; Susanna Nencetti; Tiziano Tuccinardi; Adriano Martinelli; Ngee-Han Lim; Robert Visse; Hideaki Nagase; Armando Rossello
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Journal of medicinal chemistry 2009;52(15):4757-73.
2009: Sabrina Taliani; Barbara Cosimelli; Federico Da Settimo; Anna Maria Marini; Concettina La Motta; Francesca Simorini; Silvia Salerno; Ettore Novellino; Giovanni Greco; Sandro Cosconati; Luciana Marinelli; F Salvetti; Gianluca L'Abbate; Silvia Trasciatti; Marina Montali; Barbara Costa; Claudia Martini
Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.
Journal of medicinal chemistry 2009;52(12):3723-34.
2009: Stefania Butini; Margherita Brindisi; Sandro Cosconati; Luciana Marinelli; Giuseppe Borrelli; Salvatore Sanna Coccone; Anna Ramunno; Giuseppe Campiani; Ettore Novellino; Samantha Zanoli; Alberta Samuele; Gianluca Giorgi; Alberto Bergamini; Michela Di Mattia; Silvana Lalli; Bruno Galletti; Sandra Gemma; giovanni maga
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.
Journal of medicinal chemistry 2009;52(4):1224-8.
2009: Jayanta Chatterjee; Oded Ovadia; Grit Zahn; Luciana Marinelli; Amnon Hoffman; Chaim Gilon; Horst Kessler
Highly selective cyclic hexapeptides antagonist of GPIIb-IIIa by multiple N-methylation.
Advances in experimental medicine and biology 2009;611():209-10.
2009: Dominik Heckmann; Burkhardt Laufer; Luciana Marinelli; Vittorio Limongelli; Ettore Novellino; Grit Zahn; Roland Stragies; Horst Kessler
Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity.
Angewandte Chemie (International ed. in English) 2009;48(24):4436-40.
2008: Roberto Di Santo; Roberta Costi; Alessandra Roux; Gaetano Miele; Giuliana Cuzzucoli Crucitti; Alberto Iacovo; Federica Rosi; Antonio Lavecchia; Luciana Marinelli; Carmen Di Giovanni; Ettore Novellino; Lucia Palmisano; Mauro Andreotti; Roberta Amici; Clementina M Galluzzo; Lucia Nencioni; Anna Teresa Palamara; Yves Pommier; Christophe Marchand
Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities.
Journal of medicinal chemistry 2008;51(15):4744-50.
2007: Jayanta Chatterjee; Oded Ovadia; Grit Zahn; Luciana Marinelli; Amnon Hoffman; Chaim Gilon; Horst Kessler
Multiple N-methylation by a designed approach enhances receptor selectivity.
Journal of medicinal chemistry 2007;50(24):5878-81.
2007: Luciana Marinelli; Sandro Cosconati; Thomas Steinbrecher; Vittorio Limongelli; Alessia Bertamino; Ettore Novellino; David A Case
Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding.
ChemMedChem 2007;2(10):1498-510.
2007: Vittorio Limongelli; Luciana Marinelli; Sandro Cosconati; Hannes A Braun; Boris Schmidt; Ettore Novellino
Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design.
ChemMedChem 2007;2(5):667-78.
2007: Sandro Cosconati; Luciana Marinelli; Antonio Lavecchia; Ettore Novellino
Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: model construction and docking calculations.
Journal of medicinal chemistry 2007;50(7):1504-13.
2007: Dominik Heckmann; Axel Meyer; Luciana Marinelli; Grit Zahn; Roland Stragies; Horst Kessler
Probing integrin selectivity: rational design of highly active and selective ligands for the alpha5beta1 and alphavbeta3 integrin receptor.
Angewandte Chemie (International ed. in English) 2007;46(19):3571-4.
2006: Roberto Di Santo; Roberta Costi; Alessandra Roux; Marino Artico; Antonio Lavecchia; Luciana Marinelli; Ettore Novellino; Lucia Palmisano; Mauro Andreotti; Roberta Amici; Clementina M Galluzzo; Lucia Nencioni; Anna Teresa Palamara; Yves Pommier; Christophe Marchand
Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action.
Journal of medicinal chemistry 2006;49(6):1939-45.
2005: Gjermund Henriksen; Stefan Platzer; János Marton; Andrea Hauser; Achim Berthele; Markus Schwaiger; Luciana Marinelli; Antonio Lavecchia; Ettore Novellino; Hans-Jürgen Wester
Syntheses, biological evaluation, and molecular modeling of 18F-labeled 4-anilidopiperidines as mu-opioid receptor imaging agents.
Journal of medicinal chemistry 2005;48(24):7720-32.
2005: Paolo Grieco; Alfonso Carotenuto; Pietro Campiglia; Luciana Marinelli; Teresa Lama; Riccardo Patacchini; Paolo Santicioli; Carlo A Maggi; Paolo Rovero; Ettore Novellino
Urotensin-II receptor ligands. From agonist to antagonist activity.
Journal of medicinal chemistry 2005;48(23):7290-7.
2005: Luciana Marinelli; Axel Meyer; Dominik Heckmann; Antonio Lavecchia; Ettore Novellino; Horst Kessler
Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists.
Journal of medicinal chemistry 2005;48(13):4204-7.
2004: Luciana Marinelli; Kay-Eberhard Gottschalk; Axel Meyer; Ettore Novellino; Horst Kessler
Human integrin alphavbeta5: homology modeling and ligand binding.
Journal of medicinal chemistry 2004;47(17):4166-77.
2003: Luciana Marinelli; Antonio Lavecchia; Kay-Eberhard Gottschalk; Ettore Novellino; Horst Kessler
Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design.
Journal of medicinal chemistry 2003;46(21):4393-404.
2003: Renate M van Well; Luciana Marinelli; Cornelis Altona; Kees Erkelens; Gregg Siegal; Mark van Raaij; Antonio Luis Llamas-Saiz; Horst Kessler; Ettore Novellino; Antonio Lavecchia; Jacques H van Boom; Mark Overhand
Conformational analysis of furanoid epsilon-sugar amino acid containing cyclic peptides by NMR spectroscopy, molecular dynamics simulation, and X-ray crystallography: evidence for a novel turn structure.
Journal of the American Chemical Society 2003;125(36):10822-9.
2002: Dirk Gottschling; Jürgen Boer; Luciana Marinelli; Georg Voll; Melina Haupt; Anja Schuster; Bernhard Holzmann; Horst Kessler
Synthesis and NMR structure of peptidomimetic alpha4beta7-integrin antagonists.
Chembiochem : a European journal of chemical biology 2002;3(6):575-8.
2000: P Vianello; A Albinati; Gérard A Pinna; Antonio Lavecchia; Luciana Marinelli; P A Borea; Stefania Gessi; Paola Fadda; S Tronci; Giorgio Cignarella
Synthesis, molecular modeling, and opioid receptor affinity of 9, 10-diazatricyclo[4.2.1.1(2,5)]decanes and 2,7-diazatricyclo[4.4.0. 0(3,8)]decanes structurally related to 3,8-diazabicyclo[3.2. 1]octanes.
Journal of medicinal chemistry 2000;43(11):2115-23.