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Aalt Bast

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TOP 3
Peter T Res; Rudi Stinkens; T J Tollakson; Aalt Bast; Naomi M Cermak; Guido R Haenen; Luc J C VAN Loon
Astaxanthin supplementation does not augment fat use or improve endurance performance.
Petal A H M Wijnen; Johny A Verschakelen; Aalt Bast; Otto Bekers; Marjolein Drent
Diffuse alveolar hemorrhage in coumarin users: a fibrosing interstitial pneumonia trigger?
Veerle Bieghs; Marion J J Gijbels; Yasmin Dias Guichot; Tim Hendrikx; Marten H Hofker; Mike L J Jeurissen; Satish C Kalhan; Ger H Koek; eran leitersdorf; Dieter Lütjohann; Jogchum Plat; Sander S Rensen; Patrick J van Gorp; Fons K Verheyen; Sofie M A Walenbergh; Aalt Bast; Ronit Shiri-Sverdlov
The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice.

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2013: Peter T Res; Rudi Stinkens; T J Tollakson; Aalt Bast; Naomi M Cermak; Guido R Haenen; Luc J C VAN Loon
Astaxanthin supplementation does not augment fat use or improve endurance performance.
Medicine and science in sports and exercise 2013;45(6):1158-65.
2013: Petal A H M Wijnen; Johny A Verschakelen; Aalt Bast; Otto Bekers; Marjolein Drent
Diffuse alveolar hemorrhage in coumarin users: a fibrosing interstitial pneumonia trigger?
Lung 2013;191(1):53-9.
2013: Veerle Bieghs; Marion J J Gijbels; Yasmin Dias Guichot; Tim Hendrikx; Marten H Hofker; Mike L J Jeurissen; Satish C Kalhan; Ger H Koek; eran leitersdorf; Dieter Lütjohann; Jogchum Plat; Sander S Rensen; Patrick J van Gorp; Fons K Verheyen; Sofie M A Walenbergh; Aalt Bast; Ronit Shiri-Sverdlov
The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice.
Gastroenterology 2013;144(1):167-178.e1.
2012: M G W van den Heuvel; Anton W Ambergen; Aalt Bast; G R M M Haenen; J F Mermans; René R W J van der Hulst
The role of antioxidants in ischaemia-reperfusion in a human DIEP flap model.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS 2012;65(12):1706-11.
2012: Mohamed Moalin; Gino P F van Strijdonck; Aalt Bast; Guido R M M Haenen
Competition between ascorbate and glutathione for the oxidized form of methylated quercetin metabolites and analogues: tamarixetin, 4'O-methylquercetin, has the lowest thiol reactivity.
Journal of agricultural and food chemistry 2012;60(36):9292-7.
2012: Antje R Weseler; Aalt Bast
Pleiotropic-acting nutrients require integrative investigational approaches: the example of flavonoids.
Journal of agricultural and food chemistry 2012;60(36):8941-6.
2012: Agnes W Boots; Kirsten Gerloff; Guido R M M Haenen; Kirstin Ledermann; Catrin Albrecht; Roger Bartholomé; Aalt Bast; Damien van Berlo; Frederik-Jan van Schooten; Roel P F Schins
Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells.
Biochimica et biophysica acta 2012;1823(7):1151-62.
2012: Tarek Ezzat; Massimo Malagó; Maartje A J van den Broek; Aalt Bast; Nathan Davies; Cornelis H C Dejong; Dipok K Dhar; Steven W M Olde Damink
The flavonoid monoHER prevents monocrotaline-induced hepatic sinusoidal injury in rats.
Journal of surgical oncology 2012;106(1):72-8.
2012: Nuria Mateo Anson; Youna M Hemery; Aalt Bast; Guido R M M Haenen
Optimizing the bioactive potential of wheat bran by processing.
Food & function 2012;3(4):362-75.
2012: Jaap C Hanekamp; Aalt Bast; Jan Hjm Kwakman
Of reductionism and the pendulum swing: connecting toxicology and human health.
Dose-response : a publication of International Hormesis Society 2012;10(2):155-76.
2012: Ilja C W Arts; Aalt Bast; Martijn J L Bours; Erik Jcm Coolen; Nathalie Huyghebaert; Martien A Cohen Stuart; Pieter C Dagnelie
Adenosine 5'-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans.
Journal of the International Society of Sports Nutrition 2012;9(1):16.
2011: H Jacobs; Ger H Koek; M Moalin; R Peters; J Tack; Wim J F van der Vijgh; Aalt Bast; Guido R M M Haenen
Differences in pharmacological activities of the antioxidant flavonoid monoHER in humans and mice are caused by variations in its metabolic profile.
Clinical pharmacology and therapeutics 2011;90(6):852-9.
2011: Hilde Jacobs; Mohamed Moalin; Wim J F van der Vijgh; Marike W van Gisbergen; Aalt Bast; Guido R M M Haenen
An essential difference in the reactivity of the glutathione adducts of the structurally closely related flavonoids monoHER and quercetin.
Free radical biology & medicine 2011;51(11):2118-23.
2011: Agnes W Boots; Vincent C J de Boer; Marjolein Drent; Aalt Bast; Guido R M M Haenen
Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis.
Clinical nutrition (Edinburgh, Scotland) 2011;30(4):506-12.
2011: Hilde Jacobs; Ron Peters; Gertjan J M den Hartog; Wim J F van der Vijgh; Aalt Bast; Guido R M M Haenen
Identification of the metabolites of the antioxidant flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside in mice.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(5):750-6.
2011: H Jacobs; Aalt Bast; G J Peters; W J F van der Vijgh; G R M M Haenen
The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor-κB.
British journal of cancer 2011;104(3):437-40.
2011: Erik J C M Coolen; Ilja C W Arts; Otto Bekers; Chris Vervaet; Aalt Bast; Pieter C Dagnelie
Oral bioavailability of ATP after prolonged administration.
The British journal of nutrition 2011;105(3):357-66.
2011: Mohamed Moalin; Gino P F van Strijdonck; Geja Hagemen; Aalt Bast; Maud Beckers; Paul Borm; Guido R M M Haenen
A planar conformation and the hydroxyl groups in the B and C rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives.
Molecules (Basel, Switzerland) 2011;16(11):9636-50.
2011: Nuria Mateo Anson; Anna-Marja Aura; Emilia Selinheimo; Ismo Mattila; Kaisa Poutanen; Robin van den Berg; Robert Havenaar; Aalt Bast; Guido R M M Haenen
Bioprocessing of wheat bran in whole wheat bread increases the bioavailability of phenolic acids in men and exerts antiinflammatory effects ex vivo.
The Journal of nutrition 2011;141(1):137-43.
2010: Veerle Bieghs; Anne Custers; A W D Gavilanes; Marion J Gijbels; Boris W Kramer; Dieter Lütjohann; Patrick van Gorp; Evi Vlassaks; J-Willem Voncken; Luc J I Zimmermann; Aalt Bast; Otto Bekers; Ronit Shiri-Sverdlov
Chorioamnionitis induced hepatic inflammation and disturbed lipid metabolism in fetal sheep.
Pediatric research 2010;68(6):466-72.
2010: Henrike M Hamer; Daisy M A E Jonkers; Steven Vanhoutvin; Freddy J Troost; Ger Rijkers; Adriaan P de Bruïne; Aalt Bast; Koen Venema; Robert-Jan M Brummer
Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission.
Clinical nutrition (Edinburgh, Scotland) 2010;29(6):738-44.
2010: Aalt Bast; Antje R Weseler; Guido R M M Haenen; Gertjan J M den Hartog
Oxidative stress and antioxidants in interstitial lung disease.
Current opinion in pulmonary medicine 2010;16(5):516-20.
2010: Antje R Weseler; Aalt Bast
Oxidative stress and vascular function: implications for pharmacologic treatments.
Current hypertension reports 2010;12(3):154-61.
2010: Gertjan J M den Hartog; Agnes W Boots; Aline Adam-Perrot; Fred Brouns; Inge W C M Verkooijen; Antje R Weseler; Guido R M M Haenen; Aalt Bast
Erythritol is a sweet antioxidant.
Nutrition (Burbank, Los Angeles County, Calif.) 2010;26(4):449-58.
2010: Els L R Swennen; Vanessa Ummels; Irina Buss; Ulrich Jaehde; Aalt Bast; Pieter C Dagnelie
ATP sensitizes H460 lung carcinoma cells to cisplatin-induced apoptosis.
Chemico-biological interactions 2010;184(3):338-45.
2010: Liesbeth Geraets; Astrid Haegens; Antje R Weseler; Karen Brauers; Juanita H J Vernooy; Emiel F M Wouters; Aalt Bast; Geja J Hageman
Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine.
European journal of pharmacology 2010;629(1-3):132-9.
2010: Christiaan P Beljaars; Jiska M Balk; Aalt Bast; Guido R M M Haenen
Prevention of a systematic underestimation of antioxidant activity in competition assays. The impact of unspecific reactions of the reactive species.
Biochemical and biophysical research communications 2010;392(3):346-50.
2010: Hilde Jacobs; Mohamed Moalin; Aalt Bast; Wim J F van der Vijgh; Guido R M M Haenen
An essential difference between the flavonoids monoHER and quercetin in their interplay with the endogenous antioxidant network.
PloS one 2010;5(11):e13880.
2010: Roger Bartholomé; Guido Haenen; C H Hollman; Aalt Bast; Pieter C Dagnelie; Dirk Roos; Jaap Keijer; Paul A Kroon; Paul W Needs; Ilja C W Arts
Deconjugation kinetics of glucuronidated phase II flavonoid metabolites by beta-glucuronidase from neutrophils.
Drug metabolism and pharmacokinetics 2010;25(4):379-87.
2009: Evi M Mercken; Harry R Gosker; Erica P Rutten; Emiel F Wouters; Aalt Bast; Geja J Hageman; Annemie Schols
Systemic and pulmonary oxidative stress after single-leg exercise in COPD.
Chest 2009;136(5):1291-300.
2009: Nuria Mateo Anson; Emilia Selinheimo; Rob Havenaar; Anna-Marja Aura; Ismo Mattila; Pekka Lehtinen; Aalt Bast; Kaisa Poutanen; Guido R M M Haenen
Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds.
Journal of agricultural and food chemistry 2009;57(14):6148-55.
2009: Jiska M Balk; Aalt Bast; Guido R M M Haenen
Evaluation of the accuracy of antioxidant competition assays: incorrect assumptions with major impact.
Free radical biology & medicine 2009;47(2):135-44.
2009: Agnes W Boots; Milena Hristova; David I Kasahara; Guido R M M Haenen; Aalt Bast; Albert van der Vliet
ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli.
The Journal of biological chemistry 2009;284(26):17858-67.
2009: Hilde Jacobs; Wim J F van der Vijgh; Ger H Koek; Guy J J Draaisma; Mohamed Moalin; Gino P F van Strijdonck; Aalt Bast; Guido R M M Haenen
Characterization of the glutathione conjugate of the semisynthetic flavonoid monoHER.
Free radical biology & medicine 2009;46(12):1567-73.
2009: Marieke G W van den Heuvel; Wim A Buurman; Aalt Bast; René R W J van der Hulst
Review: Ischaemia-reperfusion injury in flap surgery.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS 2009;62(6):721-6.
2009: Shufan Qi; Gertjan J M den Hartog; Aalt Bast
Superoxide radicals increase transforming growth factor-beta1 and collagen release from human lung fibroblasts via cellular influx through chloride channels.
Toxicology and applied pharmacology 2009;237(1):111-8.
2009: Liesbeth Geraets; Astrid Haegens; Karen Brauers; Jane A Haydock; Juanita Vernooy; Emiel F M Wouters; Aalt Bast; Geja J Hageman
Inhibition of LPS-induced pulmonary inflammation by specific flavonoids.
Biochemical and biophysical research communications 2009;382(3):598-603.
2009: Antje R Weseler; Liesbeth Geraets; Harald J J Moonen; Ralph J F Manders; Luc van Loon; Herman-Jan Pennings; Emiel F M Wouters; Aalt Bast; Geja J Hageman
Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes.
The Journal of nutrition 2009;139(5):952-7.
2009: Peter W de Leeuw; Aalt Bast
Tomato extract for hypertension? Editorial to "The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients" by E. Paran et al.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2009;23(2):107-8.
2009: Agnes W Boots; Marjolein Drent; Els L R Swennen; Harald J J Moonen; Aalt Bast; Guido R M M Haenen
Antioxidant status associated with inflammation in sarcoidosis: a potential role for antioxidants.
Respiratory medicine 2009;103(3):364-72.
2009: Henrike M Hamer; Daisy M A E Jonkers; Aalt Bast; Steven Vanhoutvin; Marc A J G Fischer; Andrea Kodde; Freddy J Troost; Koen Venema; Robert-Jan M Brummer
Butyrate modulates oxidative stress in the colonic mucosa of healthy humans.
Clinical nutrition (Edinburgh, Scotland) 2009;28(1):88-93.
2009: Joyce M J Houben; Evi M Mercken; Hans B Ketelslegers; Aalt Bast; Emiel F Wouters; Geja J Hageman; Annemie M W J Schols
Telomere shortening in chronic obstructive pulmonary disease.
Respiratory medicine 2009;103(2):230-6.
2009: Aalt Bast
[Internship abroad: not suitable for all medical students].
Nederlands tijdschrift voor geneeskunde 2009;153():B306.
2009: Rik de Jongh; Miriam Dambros; Guido R M M Haenen; Gertjan J M den Hartog; Aalt Bast; Philip van Kerrebroeck; Gommert A van Koeveringe
Partial bladder outlet obstruction reduces the tissue antioxidant capacity and muscle nerve density of the guinea pig bladder.
Neurourology and urodynamics 2009;28(5):461-7.
2008: Jaap C Hanekamp; Aalt Bast
Why RDAs and ULs are incompatible standards in the U-shape micronutrient model: a philosophically orientated analysis of micronutrients' standardizations.
Risk analysis : an official publication of the Society for Risk Analysis 2008;28(6):1639-52.
2008: Nuria Mateo Anson; Robin van den Berg; Rob Havenaar; Aalt Bast; Guido R M M Haenen
Ferulic acid from aleurone determines the antioxidant potency of wheat grain (Triticum aestivum L.).
Journal of agricultural and food chemistry 2008;56(14):5589-94.
2008: Shufan Qi; Gertjan J M den Hartog; Aalt Bast
Damage to lung epithelial cells and lining fluid antioxidant defense by humic acid.
Environmental toxicology and pharmacology 2008;26(1):96-101.
2008: Agnes W Boots; Lonneke C Wilms; Els L R Swennen; Jos C S Kleinjans; Aalt Bast; Guido R M M Haenen
In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers.
Nutrition (Burbank, Los Angeles County, Calif.) 2008;24(7-8):703-10.
2008: Erica P A Rutten; Mariëlle P K J Engelen; Harry R Gosker; Aalt Bast; Kirsten Cosemans; Yvonne L J Vissers; Emiel F M Wouters; Nicolaas E P Deutz; Annemie M W J Schols
Metabolic and functional effects of glutamate intake in patients with chronic obstructive pulmonary disease (COPD).
Clinical nutrition (Edinburgh, Scotland) 2008;27(3):408-15.
2008: Agnes W Boots; Guido R M M Haenen; Aalt Bast
Health effects of quercetin: from antioxidant to nutraceutical.
European journal of pharmacology 2008;585(2-3):325-37.
2008: Marcel C G van de Poll; Cornelis H C Dejong; Marc A J G Fischer; Aalt Bast; Ger H Koek
Decreased hepatosplanchnic antioxidant uptake during hepatic ischaemia/reperfusion in patients undergoing liver resection.
Clinical science (London, England : 1979) 2008;114(8):553-60.
2008: Erik J C M Coolen; Ilja C W Arts; Els L R Swennen; Aalt Bast; Martien A Cohen Stuart; Pieter C Dagnelie
Simultaneous determination of adenosine triphosphate and its metabolites in human whole blood by RP-HPLC and UV-detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;864(1-2):43-51.
2008: Els L R Swennen; Pieter C Dagnelie; Twan van den Beucken; Aalt Bast
Radioprotective effects of ATP in human blood ex vivo.
Biochemical and biophysical research communications 2008;367(2):383-7.
2008: Els L R Swennen; Erik J C M Coolen; Ilja C W Arts; Aalt Bast; Pieter C Dagnelie
Time-dependent effects of ATP and its degradation products on inflammatory markers in human blood ex vivo.
Immunobiology 2008;213(5):389-97.
2007: Petal A H M Wijnen; Robert A M op den Buijsch; Marjolein Drent; P M J C Kuijpers; P M J C Kuipers; Cees Neef; Aalt Bast; Otto Bekers; Ger H Koek
Review article: The prevalence and clinical relevance of cytochrome P450 polymorphisms.
Alimentary pharmacology & therapeutics 2007;26 Suppl 2():211-9.
2007: Saskia J Rietjens; Milou Beelen; René Koopman; Luc van Loon; Aalt Bast; Guido R M M Haenen
A single session of resistance exercise induces oxidative damage in untrained men.
Medicine and science in sports and exercise 2007;39(12):2145-51.
2007: Liesbeth Geraets; Harald J J Moonen; Karen Brauers; Ralph W H Gottschalk; Emiel F M Wouters; Aalt Bast; Geja J Hageman
Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression.
European journal of pharmacology 2007;573(1-3):241-8.
2007: Jaap C Hanekamp; Aalt Bast
Hormesis in precautionary regulatory culture: models preferences and the advancement of science.
Human & experimental toxicology 2007;26(11):855-73.
2007: Anna M E Bruynzeel; Hans W M Niessen; Jean G F Bronzwaer; Jacobus J M van Der Hoeven; Johannes Berkhof; Aalt Bast; Wim J F van der Vijgh; Cees J van Groeningen
The effect of monohydroxyethylrutoside on doxorubicin-induced cardiotoxicity in patients treated for metastatic cancer in a phase II study.
British journal of cancer 2007;97(8):1084-9.
2007: Liesbeth Geraets; Harald J J Moonen; Karen Brauers; Emiel F M Wouters; Aalt Bast; Geja J Hageman
Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells.
The Journal of nutrition 2007;137(10):2190-5.
2007: Saskia J Rietjens; Aalt Bast; Guido R M M Haenen
New insights into controversies on the antioxidant potential of the olive oil antioxidant hydroxytyrosol.
Journal of agricultural and food chemistry 2007;55(18):7609-14.
2007: Charlotte M H H T Robroeks; K D G van de Kant; Quirijn Jöbsis; Han J E Hendriks; R van Gent; Emiel F M Wouters; J G M C Damoiseaux; Aalt Bast; W K W H Wodzig; Edward Dompeling
Exhaled nitric oxide and biomarkers in exhaled breath condensate indicate the presence, severity and control of childhood asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(9):1303-11.
2007: Helena Kaiserová; Tomás Simůnek; Wim J F van der Vijgh; Aalt Bast; Eva Kvasnicková
Flavonoids as protectors against doxorubicin cardiotoxicity: role of iron chelation, antioxidant activity and inhibition of carbonyl reductase.
Biochimica et biophysica acta 2007;1772(9):1065-74.
2007: Anna M E Bruynzeel; Suzanne Vormer-Bonne; Aalt Bast; Hans W M Niessen; Wim J F van der Vijgh
Long-term effects of 7-monohydroxyethylrutoside (monoHER) on DOX-induced cardiotoxicity in mice.
Cancer chemotherapy and pharmacology 2007;60(4):509-14.
2007: Mariken J T J Arts; Christoph Grun; Ruud L de Jong; Hans-Peter Voss; Aalt Bast; Martin J Mueller; Guido R M M Haenen
Oxidative degradation of lipids during mashing.
Journal of agricultural and food chemistry 2007;55(17):7010-4.
2007: Agnes W Boots; Hui Li; Roel P F Schins; Rodger Duffin; Johan W M Heemskerk; Aalt Bast; Guido R M M Haenen
The quercetin paradox.
Toxicology and applied pharmacology 2007;222(1):89-96.
2007: Saskia J Rietjens; Aalt Bast; J de Vente; Guido R M M Haenen
The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NObullet response of isolated rat aorta.
American journal of physiology. Heart and circulatory physiology 2007;292(4):H1931-6.
2007: Anna M E Bruynzeel; Mohamed A I Abou El Hassan; Casper G Schalkwijk; Johannes Berkhof; Aalt Bast; Hans W M Niessen; Wim J F van der Vijgh
Anti-inflammatory agents and monoHER protect against DOX-induced cardiotoxicity and accumulation of CML in mice.
British journal of cancer 2007;96(6):937-43.
2007: Martijn J L Bours; Freddy J Troost; Robert-Jan M Brummer; Aalt Bast; Pieter C Dagnelie
Local effect of adenosine 5'-triphosphate on indomethacin-induced permeability changes in the human small intestine.
European journal of gastroenterology & hepatology 2007;19(3):245-50.
2007: Anna M E Bruynzeel; Mohamed A I Abou El Hassan; Emine Torun; Aalt Bast; Wim J F van der Vijgh; Frank A E Kruyt
Caspase-dependent and -independent suppression of apoptosis by monoHER in Doxorubicin treated cells.
British journal of cancer 2007;96(3):450-6.
2007: Rik P Bogers; Pieter C Dagnelie; Aalt Bast; Marcella van Leeuwen; Jacob D van Klaveren; Piet A van den Brandt
Effect of increased vegetable and fruit consumption on plasma folate and homocysteine concentrations.
Nutrition (Burbank, Los Angeles County, Calif.) 2007;23(2):97-102.
2007: Aalt Bast; Guido R M M Haenen; Anna M E Bruynzeel; Wim J F van der Vijgh
Protection by flavonoids against anthracycline cardiotoxicity: from chemistry to clinical trials.
Cardiovascular toxicology 2007;7(2):154-9.
2007: Helena Kaiserová; Tomas Simunek; Martin Sterba; Gertjan J M den Hartog; Ladislava Schröterová; Olga Popelová; Vladimír Gersl; Eva Kvasnicková; Aalt Bast
New iron chelators in anthracycline-induced cardiotoxicity.
Cardiovascular toxicology 2007;7(2):145-50.
2007: Bashir M Rezk; Wim J F van der Vijgh; Aalt Bast; Guido R M M Haenen
Alpha-tocopheryl phosphate is a novel apoptotic agent.
Frontiers in bioscience : a journal and virtual library 2007;12():2013-9.
2007: Aalt Bast; Helena Kaiserová; Gertjan J M den Hartog; Guido R M M Haenen; Wim J F van der Vijgh
Protectors against doxorubicin-induced cardiotoxicity: flavonoids.
Cell biology and toxicology 2007;23(1):39-47.
2006: Helena Kaiserová; Gertjan J M den Hartog; T Simůnek; Ladislava Schröterová; Eva Kvasnicková; Aalt Bast
Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin.
British journal of pharmacology 2006;149(7):920-30.
2006: Anna M E Bruynzeel; Paula P N Mul; Johannes Berkhof; Aalt Bast; Hans W M Niessen; Wim J F van der Vijgh
The influence of the time interval between monoHER and doxorubicin administration on the protection against doxorubicin-induced cardiotoxicity in mice.
Cancer chemotherapy and pharmacology 2006;58(5):699-702.
2006: Els L R Swennen; Aalt Bast; Pieter C Dagnelie
Purinergic receptors involved in the immunomodulatory effects of ATP in human blood.
Biochemical and biophysical research communications 2006;348(3):1194-9.
2006: Liesbeth Geraets; Harald J J Moonen; Emiel F M Wouters; Aalt Bast; Geja J Hageman
Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations.
Biochemical pharmacology 2006;72(7):902-10.
2006: Philippe P R Rosias; Gertjan J M den Hartog; Charlotte M H H T Robroeks; Aalt Bast; Raymond Donckerwolcke; Jan W C M Heynens; Joelle Suykerbuyk; Han J E Hendriks; Quirijn Jöbsis; Edward Dompeling
Free radicals in exhaled breath condensate in cystic fibrosis and healthy subjects.
Free radical research 2006;40(9):901-9.
2006: Anja M Willems; Anna M E Bruynzeel; Marc A Kedde; Cees J van Groeningen; Aalt Bast; Wim J F van der Vijgh
A phase I study of monohydroxyethylrutoside in healthy volunteers.
Cancer chemotherapy and pharmacology 2006;57(5):678-84.
2006: Freddy J Troost; Robert-Jan M Brummer; Guido R M M Haenen; Aalt Bast; Rachel I M van Haaften; Chris T A Evelo; Wim H M Saris
Gene expression in human small intestinal mucosa in vivo is mediated by iron-induced oxidative stress.
Physiological genomics 2006;25(2):242-9.
2006: Guido R M M Haenen; Mariken J T J Arts; Aalt Bast; Michael D Coleman
Structure and activity in assessing antioxidant activity in vitro and in vivo A critical appraisal illustrated with the flavonoids.
Environmental toxicology and pharmacology 2006;21(2):191-8.
2006: Els L R Swennen; Pieter C Dagnelie; Aalt Bast
ATP inhibits hydroxyl radical formation and the inflammatory response of stimulated whole blood even under circumstances of severe oxidative stress.
Free radical research 2006;40(1):53-8.
2005: Harald J J Moonen; Liesbeth Geraets; Anika Vaarhorst; Aalt Bast; Emiel F M Wouters; Geja J Hageman
Theophylline prevents NAD+ depletion via PARP-1 inhibition in human pulmonary epithelial cells.
Biochemical and biophysical research communications 2005;338(4):1805-10.
2005: Agnes W Boots; Jiska M Balk; Aalt Bast; Guido R M M Haenen
The reversibility of the glutathionyl-quercetin adduct spreads oxidized quercetin-induced toxicity.
Biochemical and biophysical research communications 2005;338(2):923-9.
2005: Miriam Dambros; Rik de Jongh; Gommert A van Koeveringe; Aalt Bast; Philip van Kerrebroeck
Galangin protects pig detrusor nerves from repetitive field stimulation and anoxia/glucopenia injury.
Urology 2005;66(6):1327-31.
2005: Evi M Mercken; Geja J Hageman; Annemie M W J Schols; Marco A Akkermans; Aalt Bast; Emiel F M Wouters
Rehabilitation decreases exercise-induced oxidative stress in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2005;172(8):994-1001.
2005: Miriam Dambros; Rik de Jongh; Gommert A van Koeveringe; Aalt Bast; C G M Heijnen; Philip van Kerrebroeck
Flavonoid galangin prevents smooth muscle fatigue of pig urinary bladder.
The Journal of pharmacy and pharmacology 2005;57(5):617-22.
2005: Els L R Swennen; Aalt Bast; Pieter C Dagnelie
Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood.
European journal of immunology 2005;35(3):852-8.
2005: Agnes W Boots; Aalt Bast; Guido R M M Haenen
No role of DT-diaphorase (NQO1) in the protection against oxidized quercetin.
FEBS letters 2005;579(3):677-82.
2005: Gudrun Michels; Wim Wätjen; Petra Niering; Bärbel Steffan; Q-H Tran Thi; Yvonni Chovolou; Andreas Kampkötter; Aalt Bast; Peter Proksch; Regine Kahl
Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells.
Toxicology 2005;206(3):337-48.
2005: Marc A J G Fischer; Theo J M Gransier; Lenie M G Beckers; Otto Bekers; Aalt Bast; Guido R M M Haenen
Determination of the antioxidant capacity in blood.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2005;43(7):735-40.
2005: Harry R Gosker; Aalt Bast; Guido R M M Haenen; Marc A J G Fischer; Ger J van der Vusse; Emiel F M Wouters; Annemie M W J Schols
Altered antioxidant status in peripheral skeletal muscle of patients with COPD.
Respiratory medicine 2005;99(1):118-25.
2004: Lucia De Franceschi; Franco Turrini; Marek Honczarenko; Kodjo Ayi; Alicia Rivera; Mark D Fleming; Terry Law; Franca Mannu; Frans A Kuypers; Aalt Bast; Wim J F van der Vijgh; Carlo Brugnara
In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia.
Haematologica 2004;89(11):1287-98.
2004: Miriam Dambros; Gommert A van Koeveringe; Aalt Bast; Philip van Kerrebroeck
Relaxant effects of estradiol through non-genomic pathways in male and female pig bladder smooth muscle.
Pharmacology 2004;72(2):121-7.
2004: Miranda Verschraagen; Epie Boven; Emine Torun; FREDERICK HAUSHEER; Aalt Bast; Wim J F van der Vijgh
Possible (enzymatic) routes and biological sites for metabolic reduction of BNP7787, a new protector against cisplatin-induced side-effects.
Biochemical pharmacology 2004;68(3):493-502.
2004: Bashir M Rezk; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
The extraordinary antioxidant activity of vitamin E phosphate.
Biochimica et biophysica acta 2004;1683(1-3):16-21.
2004: Tijl De Celle; Peter Heeringa; Agnieska E Strzelecka; Aalt Bast; Jos F M Smits; Ben J A Janssen
Sustained protective effects of 7-monohydroxyethylrutoside in an in vivo model of cardiac ischemia-reperfusion.
European journal of pharmacology 2004;494(2-3):205-12.
2004: Gudrun Michels; Guido R M M Haenen; Wim Wätjen; Saskia J Rietjens; Aalt Bast
The thiol reactivity of the oxidation product of 3,5,7-trihydroxy-4H-chromen-4-one containing flavonoids.
Toxicology letters 2004;151(1):105-11.
2004: Bashir M Rezk; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
Lipoic acid protects efficiently only against a specific form of peroxynitrite-induced damage.
The Journal of biological chemistry 2004;279(11):9693-7.
2004: Gertjan J M den Hartog; Guido R M M Haenen; Epie Boven; Wim J F van der Vijgh; Aalt Bast
Lecithinized copper,zinc-superoxide dismutase as a protector against doxorubicin-induced cardiotoxicity in mice.
Toxicology and applied pharmacology 2004;194(2):180-8.
2004: Mariken J T J Arts; Guido R M M Haenen; Hans-Peter Voss; Aalt Bast
Antioxidant capacity of reaction products limits the applicability of the Trolox Equivalent Antioxidant Capacity (TEAC) assay.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(1):45-9.
2003: Bashir M Rezk; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore.
FEBS letters 2003;555(3):601-5.
2003: Mohamed A I Abou El Hassan; M J W E Rabelink; Wim J F van der Vijgh; Aalt Bast; Rob Hoeben
A comparative study between catalase gene therapy and the cardioprotector monohydroxyethylrutoside (MonoHER) in protecting against doxorubicin-induced cardiotoxicity in vitro.
British journal of cancer 2003;89(11):2140-6.
2003: Agnes W Boots; Guido R M M Haenen; Aalt Bast
Oxidant metabolism in chronic obstructive pulmonary disease.
The European respiratory journal. Supplement 2003;46():14s-27s.
2003: Mohamed A I Abou El Hassan; Marc A Kedde; Ursula T H Zwiers; E Tourn; Guido R M M Haenen; Aalt Bast; Wim J F van der Vijgh
Bioavailability and pharmacokinetics of the cardioprotecting flavonoid 7-monohydroxyethylrutoside in mice.
Cancer chemotherapy and pharmacology 2003;52(5):371-6.
2003: Marjolein Drent; Anton P Gorgels; Aalt Bast
Cardiac failure associated with G6PD deficiency.
Circulation research 2003;93(8):e75.
2003: Eduardo Villamor; Carolina G A Kessels; Marc A J Fischer; Aalt Bast; Jo De Mey; carlos blanco
Role of superoxide anion on basal and stimulated nitric oxide activity in neonatal piglet pulmonary vessels.
Pediatric research 2003;54(3):372-81.
2003: Agnes W Boots; Nard Kubben; Guido R M M Haenen; Aalt Bast
Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation.
Biochemical and biophysical research communications 2003;308(3):560-5.
2003: Freddy J Troost; Wim H M Saris; Guido R M M Haenen; Aalt Bast; Robert-Jan M Brummer
New method to study oxidative damage and antioxidants in the human small bowel: effects of iron application.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(2):G354-9.
2003: Mohamed A I Abou El Hassan; Hendrik Verheul; Anita S Jorna; Casper G Schalkwijk; J van Bezu; Wim J F van der Vijgh; Aalt Bast
The new cardioprotector Monohydroxyethylrutoside protects against doxorubicin-induced inflammatory effects in vitro.
British journal of cancer 2003;89(2):357-62.
2003: Geja J Hageman; Ingrid Larik; Herman-Jan Pennings; Guido R M M Haenen; Emiel F M Wouters; Aalt Bast
Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients.
Free radical biology & medicine 2003;35(2):140-8.
2003: Rachel I M van Haaften; Guido R M M Haenen; Peter J van Bladeren; Jan J P Bogaards; Chris T A Evelo; Aalt Bast
Inhibition of various glutathione S-transferase isoenzymes by RRR-alpha-tocopherol.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(3):245-51.
2003: Rachel I M van Haaften; Guido R M M Haenen; Chris T A Evelo; Aalt Bast
Effect of vitamin E on glutathione-dependent enzymes.
Drug metabolism reviews 2003;35(2-3):215-53.
2003: Mohamed A I Abou El Hassan; Marc A Kedde; Ursula T H Zwiers; Aalt Bast; Wim J F van der Vijgh
The cardioprotector monoHER does not interfere with the pharmacokinetics or the metabolism of the cardiotoxic agent doxorubicin in mice.
Cancer chemotherapy and pharmacology 2003;51(4):306-10.
2003: Mohamed A I Abou El Hassan; M Heijn; M J W E Rabelink; Wim J F van der Vijgh; Aalt Bast; Rob Hoeben
The protective effect of cardiac gene transfer of CuZn-sod in comparison with the cardioprotector monohydroxyethylrutoside against doxorubicin-induced cardiotoxicity in cultured cells.
Cancer gene therapy 2003;10(4):270-7.
2003: Rik P Bogers; Pieter C Dagnelie; Klaas R Westerterp; Arnold D M Kester; Jacob D van Klaveren; Aalt Bast; Piet A van den Brandt
Using a correction factor to correct for overreporting in a food-frequency questionnaire does not improve biomarker-assessed validity of estimates for fruit and vegetable consumption.
The Journal of nutrition 2003;133(4):1213-9.
2003: Gertjan J M den Hartog; Agnes W Boots; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
Lack of inhibition of endothelial nitric oxide synthase in the isolated rat aorta by doxorubicin.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(2):165-7.
2003: Gertjan J M den Hartog; Guido R M M Haenen; Erik Vegt; Wim J F van der Vijgh; Aalt Bast
Superoxide dismutase: the balance between prevention and induction of oxidative damage.
Chemico-biological interactions 2003;145(1):33-9.
2003: Aalt Bast; Guido R M M Haenen
Lipoic acid: a multifunctional antioxidant.
BioFactors (Oxford, England) 2003;17(1-4):207-13.
2002: Aalt Bast; R Frank Chandler; Patrick C Choy; Ellen M de Ree; Luc M Delmulle; Joerg Gruenwald; S Bart A Halkes; Konstantin Keller; Jan H Koeman; Paul Peters; Hildegard Przyrembel; Andrew G Renwick; Ingrid T M Vermeer
Botanical health products, positioning and requirements for effective and safe use.
Environmental toxicology and pharmacology 2002;12(4):195-211.
2002: Agnes W Boots; Guido R M M Haenen; Gertjan J M den Hartog; Aalt Bast
Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants.
Biochimica et biophysica acta 2002;1583(3):279-84.
2002: Rachel I M van Haaften; Guido R M M Haenen; Chris T A Evelo; Aalt Bast
Tocotrienols inhibit human glutathione S-transferase P1-1.
IUBMB life 2002;54(2):81-4.
2002: Bashir M Rezk; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids.
Biochemical and biophysical research communications 2002;295(1):9-13.
2002: Aalt Bast; Guido R M M Haenen
The toxicity of antioxidants and their metabolites.
Environmental toxicology and pharmacology 2002;11(3-4):251-8.
2002: Jan W Dallinga; Guido R M M Haenen; Aalt Bast; Frederik J Van Schooten
The effect of the trolox equivalent antioxidant capacity (TEAC) in plasma on the formation of 4-aminobiphenylhaemoglobin adducts in smokers.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2002;7(4):291-8.
2002: Gertjan J M den Hartog; Erik Vegt; Wim J F van der Vijgh; Guido R M M Haenen; Aalt Bast
Hypochlorous acid is a potent inhibitor of acetylcholinesterase.
Toxicology and applied pharmacology 2002;181(3):228-32.
2002: Snjezana Rothkrantz-Kos; Marjolein Drent; Herma Vuil; Martin De Boer; Aalt Bast; Emiel F M Wouters; Dirk Roos; Marja Van Dieijen-Visser
Decreased redox state in red blood cells from patients with sarcoidosis.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 2002;19(2):114-20.
2002: Chantal G M Heijnen; Guido R M M Haenen; R Minou Oostveen; Eva M Stalpers; Aalt Bast
Protection of flavonoids against lipid peroxidation: the structure activity relationship revisited.
Free radical research 2002;36(5):575-81.
2002: Gertjan J M den Hartog; Guido R M M Haenen; Erik Vegt; Wim J F van der Vijgh; Aalt Bast
Efficacy of HOCl scavenging by sulfur-containing compounds: antioxidant activity of glutathione disulfide?
Biological chemistry 2002;383(3-4):709-13.
2002: Mariken J T J Arts; Guido R M M Haenen; Lonneke C Wilms; Sasja A J N Beetstra; Chantal G M Heijnen; Hans-Peter Voss; Aalt Bast
Interactions between flavonoids and proteins: effect on the total antioxidant capacity.
Journal of agricultural and food chemistry 2002;50(5):1184-7.
2002: Helen R Griffiths; Lennart Møller; Grzegorz Bartosz; Aalt Bast; Carlo Bertoni-Freddari; Andrew Collins; Marcus Cooke; Stefan A J Coolen; Guido Haenen; Anne Mette Hoberg; Steffen Loft; Joseph Lunec; Ryszard Olinski; James Parry; Alfonso Pompella; Henrik Poulsen; Hans Verhagen; Siân B Astley
Biomarkers.
Molecular aspects of medicine 2002;23(1-3):101-208.
2002: Wilhelm Stahl; Henk van den Berg; John Arthur; Aalt Bast; Jack Dainty; Richard Faulks; Christine Gärtner; Guido Haenen; Peter Hollman; Birgit Holst; Frank Kelly; M Cristina Polidori; Catherine Rice-Evans; Susan Southon; Ton van Vliet; José Viña-Ribes; Gary Williamson; Siân B Astley
Bioavailability and metabolism.
Molecular aspects of medicine 2002;23(1-3):39-100.
2002: Erwin P Meijer; Annelies H C Goris; Joost L J van Dongen; Aalt Bast; Klaas R Westerterp
Exercise-induced oxidative stress in older adults as a function of habitual activity level.
Journal of the American Geriatrics Society 2002;50(2):349-53.
2002: Frederik J Van Schooten; Ahmad Besaratinia; Ahmad Besarati Nia; Silvio De Flora; Francesco D'Agostini; Alberto Izzotti; Anna Camoirano; Alfons J M Balm; Jan W Dallinga; Aalt Bast; Guido R M M Haenen; Laura Van't Veer; Paul Baas; Harumasa Sakai; nico van zandwijk
Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(2):167-75.
2001: Erwin P Meijer; S A Coolen; Aalt Bast; Klaas R Westerterp
Exercise-induced oxidative stress in older adults as measured by antipyrine oxidation.
Metabolism: clinical and experimental 2001;50(12):1484-8.
2001: Erwin P Meijer; Annelies H C Goris; Joan M G Senden; Joost L J van Dongen; Aalt Bast; Klaas R Westerterp
Antioxidant supplementation and exercise-induced oxidative stress in the 60-year-old as measured by antipyrine hydroxylates.
The British journal of nutrition 2001;86(5):569-75.
2001: Rachel I M van Haaften; Gertjan J M den Hartog; Chris T A Evelo; Guido R M M Haenen; Aalt Bast
Hypochlorous acid is a potent inhibitor of GST P1-1.
Chemico-biological interactions 2001;138(1):77-83.
2001: Erwin P Meijer; S A Coolen; Aalt Bast; Klaas R Westerterp
Exercise training and oxidative stress in the elderly as measured by antipyrine hydroxylation products.
Free radical research 2001;35(4):435-43.
2001: C G Heijnen; J A Vekemans; Guido R M M Haenen; Aalt Bast
Peroxynitrite scavenging of flavonoids: structure activity relationship.
Environmental toxicology and pharmacology 2001;10(4):199-206.
2001: Mariken J T J Arts; Guido R M M Haenen; Hans-Peter Voss; Aalt Bast
Masking of antioxidant capacity by the interaction of flavonoids with protein.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001;39(8):787-91.
2001: Rachel I M van Haaften; Chris T A Evelo; John Penders; M P Eijnwachter; Guido R M M Haenen; Aalt Bast
Inhibition of human glutathione S-transferase P1-1 by tocopherols and alpha-tocopherol derivatives.
Biochimica et biophysica acta 2001;1548(1):23-8.
2001: FA van Acker; Janneke W Hulshof; Guido R M M Haenen; Wiro M P B Menge; Wim J F van der Vijgh; Aalt Bast
New synthetic flavonoids as potent protectors against doxorubicin-induced cardiotoxicity.
Free radical biology & medicine 2001;31(1):31-7.
2001: Mohamed A I Abou El Hassan; Marc A Kedde; Aalt Bast; Wim J F van der Vijgh
Determination of monohydroxyethylrutoside in heart tissue by high-performance liquid chromatography with electrochemical detection.
Journal of chromatography. B, Biomedical sciences and applications 2001;757(1):191-6.
2001: JP Rhemrev; Jan P W Vermeiden; Guido R M M Haenen; J J De Bruijne; Lyset T M Rekers-Mombarg; Aalt Bast
Progressively motile human spermatozoa are well protected against in vitro lipid peroxidation imposed by induced oxidative stress.
Andrologia 2001;33(3):151-8.
2001: FA van Acker; Epie Boven; Klaas Kramer; Guido R M M Haenen; Aalt Bast; Wim J F van der Vijgh
Frederine, a new and promising protector against doxorubicin-induced cardiotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1378-84.
2001: Rachel I M van Haaften; Chris T A Evelo; Guido R M M Haenen; Aalt Bast
No reduction of alpha-tocopherol quinone by glutathione in rat liver microsomes.
Biochemical pharmacology 2001;61(6):715-9.
2001: M A El Hassan; Marc A Kedde; Aalt Bast; Wim J F van der Vijgh
High-performance liquid chromatography with electrochemical detection for the determination of 7-monohydroxyethylrutoside in plasma.
Journal of chromatography. B, Biomedical sciences and applications 2001;752(1):115-21.
2001: Marjolein Drent; R van den Berg; G R Haenen; H van den Berg; Emiel F M Wouters; Aalt Bast
NF-kappaB activation in sarcoidosis.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 2001;18(1):50-6.
2001: C G Heijnen; Guido R M M Haenen; FA van Acker; Wim J F van der Vijgh; Aalt Bast
Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups.
Toxicology in vitro : an international journal published in association with BIBRA 2001;15(1):3-6.
2001: Rachel I M van Haaften; Chris T A Evelo; Guido R M M Haenen; Aalt Bast
alpha-Tocopherol inhibits human glutathione S-transferase pi.
Biochemical and biophysical research communications 2001;280(3):631-3.
2000: Mohamed A I Abou El Hassan; D J Touw; Abraham Wilhelm; Aalt Bast; Wim J F van der Vijgh
Stability of monoHER in an aqueous formulation for i.v. administration.
International journal of pharmaceutics 2000;211(1-2):51-6.
2000: FA van Acker; Saskia van Acker; Guido R M M Haenen; Aalt Bast; Wim J F van der Vijgh
In vitro screening of antitumour agents for cardiotoxicity by means of isolated mouse left atria.
Anticancer research 2000;20(6B):4483-7.
2000: JP Rhemrev; FW van Overveld; Guido R M M Haenen; T Teerlink; Aalt Bast; Jan P W Vermeiden
Quantification of the nonenzymatic fast and slow TRAP in a postaddition assay in human seminal plasma and the antioxidant contributions of various seminal compounds.
Journal of andrology 2000;21(6):913-20.
2000: JB Paquay; Guido R M M Haenen; G Stender; Sheila A Wiseman; Lilian B M Tijburg; Aalt Bast
Protection against nitric oxide toxicity by tea.
Journal of agricultural and food chemistry 2000;48(11):5768-72.
2000: FA van Acker; J A Hageman; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast; Wiro M P B Menge
Synthesis of novel 3,7-substituted-2-(3',4'-dihydroxyphenyl)flavones with improved antioxidant activity.
Journal of medicinal chemistry 2000;43(20):3752-60.
2000: L A van Vliet; Nienke Rodenhuis; Håkan V Wikström; Thomas A Pugsley; Kevin A Serpa; Leonard T Meltzer; Thomas G Heffner; Lawrence D Wise; ME Lajiness; Rita M Huff; Kjell A Svensson; Guido R M M Haenen; Aalt Bast
Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists.
Journal of medicinal chemistry 2000;43(19):3549-57.
2000: GJ Westerveld; HP Voss; R M van der Hee; G J de Haan-Koelewijn; Gijsbertus den Hartog; Robert A Scheeren; Aalt Bast
Inhibition of nitric oxide synthase by nasal decongestants.
The European respiratory journal 2000;16(3):437-44.
2000: Marjolein Drent; P H Bomans; Robert J van Suylen; Rob Lamers; Aalt Bast; Emiel F M Wouters
Association of man-made mineral fibre exposure and sarcoidlike granulomas.
Respiratory medicine 2000;94(8):815-20.
2000: FW van Overveld; Guido R M M Haenen; JP Rhemrev; Jan P W Vermeiden; Aalt Bast
Tyrosine as important contributor to the antioxidant capacity of seminal plasma.
Chemico-biological interactions 2000;127(2):151-61.
2000: FA van Acker; O Schouten; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
Flavonoids can replace alpha-tocopherol as an antioxidant.
FEBS letters 2000;473(2):145-8.
2000: FA van Acker; Saskia van Acker; Klaas Kramer; Guido R M M Haenen; Aalt Bast; Wim J F van der Vijgh
7-monohydroxyethylrutoside protects against chronic doxorubicin-induced cardiotoxicity when administered only once per week.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1337-41.
1999: JB Paquay; P A Hoen; H P Voss; Aalt Bast; H Timmerman; G R Haenen
Nitric oxide synthase inhibition by dimaprit and dimaprit analogues.
British journal of pharmacology 1999;127(2):331-4.
1998: Saskia van Acker; G P van Balen; D J van den Berg; Aalt Bast; Wim J F van der Vijgh
Influence of iron chelation on the antioxidant activity of flavonoids.
Biochemical pharmacology 1998;56(8):935-43.
1998: V H Karsdorp; Gustaaf A Dekker; Aalt Bast; Gerard J van Kamp; Anneke A Bouman; John M G van Vugt; Herman P van Geijn
Maternal and fetal plasma concentrations of endothelin, lipidhydroperoxides, glutathione peroxidase and fibronectin in relation to abnormal umbilical artery velocimetry.
European journal of obstetrics, gynecology, and reproductive biology 1998;80(1):39-44.
1998: Herman-Jan Pennings; K Kramer; Aalt Bast; Wim A Buurman; Emiel F M Wouters
Tumour necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea-pig in vitro.
The European respiratory journal 1998;12(1):45-9.
1998: HJ van Hoof; Gijsbertus den Hartog; HP Voss; Leendert van Bree; Aalt Bast
Capsaicin treatment induces muscarinic hyperreactivity in guinea pig trachea: a warning.
European journal of pharmacology 1998;347(2-3):261-4.
1998: Klaas Kramer; JA Grimbergen; D J van Iperen; Klaas Van Altena; H P Voss; Aalt Bast
Oral endotrachael intubation of guineapigs.
Laboratory animals 1998;32(2):162-4.
1998: GP Biewenga; D H Veening-Griffioen; A J Nicastia; Guido R M M Haenen; Aalt Bast
Effects of dihydrolipoic acid on peptide methionine sulfoxide reductase. Implications for antioxidant drugs.
Arzneimittel-Forschung 1998;48(2):144-8.
1998: HJ van Hoof; HP Voss; Freek Jan Zijlstra; C J Tak; Leendert van Bree; Aalt Bast
The role of prostanoids in ozone-induced changes in airway responsiveness: receptor activation-specific prostanoid release.
Environmental toxicology and pharmacology 1998;5(1):69-78.
1997: J B Paquay; M T Bolscher; H P Voss; H Timmerman; Aalt Bast
Difference in the inhibition of nitric oxide synthase and cytochrome P-450 by some H(2)-antagonists.
Toxicology in vitro : an international journal published in association with BIBRA 1997;11(6):775-8.
1997: M F Vriesman; Guido R M M Haenen; GJ Westerveld; JB Paquay; HP Voss; Aalt Bast
A method for measuring nitric oxide radical scavenging activity. Scavenging properties of sulfur-containing compounds.
Pharmacy world & science : PWS 1997;19(6):283-6.
1997: GP Biewenga; Guido R M M Haenen; Aalt Bast
The role of lipoic acid in the treatment of diabetic polyneuropathy.
Drug metabolism reviews 1997;29(4):1025-54.
1997: Saskia van Acker; Epie Boven; K Kuiper; D J van den Berg; JA Grimbergen; Klaas Kramer; Aalt Bast; Wim J F van der Vijgh
Monohydroxyethylrutoside, a dose-dependent cardioprotective agent, does not affect the antitumor activity of doxorubicin.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(10):1747-54.
1997: K Kramer; C G Smink; Aalt Bast
Effect of phospholipase A2 activation on the receptor function in the rat left atrium: unmasking of a positive inotropic effect of methacholine.
General pharmacology 1997;29(3):441-6.
1997: GP Biewenga; Guido R M M Haenen; Aalt Bast
The pharmacology of the antioxidant lipoic acid.
General pharmacology 1997;29(3):315-31.
1997: Guido R M M Haenen; JB Paquay; R E Korthouwer; Aalt Bast
Peroxynitrite scavenging by flavonoids.
Biochemical and biophysical research communications 1997;236(3):591-3.
1997: HJ van Hoof; HP Voss; K Kramer; john boere; J A M A Dormans; Leendert van Bree; Aalt Bast
Changes in neuroreceptor function of tracheal smooth muscle following acute ozone exposure of guinea pigs.
Toxicology 1997;120(3):159-69.
1997: GJ Westerveld; I Dekker; HP Voss; Aalt Bast; Robert A Scheeren
Antioxidant levels in the nasal mucosa of patients with chronic sinusitis and healthy controls.
Archives of otolaryngology--head & neck surgery 1997;123(2):201-4.
1997: HJ van Hoof; FA van Acker; HP Voss; Leendert van Bree; Aalt Bast
Acute exposure to ozone does not influence neuroreceptor density and sensitivity in guinea pig lung.
Toxicology letters 1997;90(1):53-60.
1997: HJ van Hoof; Freek Jan Zijlstra; HP Voss; I M Garrelds; J A M A Dormans; Leendert van Bree; Aalt Bast
The effect of ozone exposure on the release of eicosanoids in guinea-pig BAL fluid in relation to cellular damage and inflammation.
Mediators of inflammation 1997;6(5-6):355-61.
1996: Saskia van Acker; Marcel J de Groot; D J van den Berg; M N Tromp; G Donné-Op den Kelder; Wim J F van der Vijgh; Aalt Bast
A quantum chemical explanation of the antioxidant activity of flavonoids.
Chemical research in toxicology 1996;9(8):1305-12.
1996: Aalt Bast; R M van der Plas; H van den Berg; Guido R M M Haenen
Beta-carotene as antioxidant.
European journal of clinical nutrition 1996;50 Suppl 3():S54-6.
1996: G P Biewenga; M A Dorstijn; J V Verhagen; Guido R M M Haenen; Aalt Bast
Reduction of lipoic acid by lipoamide dehydrogenase.
Biochemical pharmacology 1996;51(3):233-8.
1996: I H van Hoof; Leendert van Bree; Aalt Bast
Changes in receptor function by oxidative stress in guinea pig tracheal smooth muscle.
Central European journal of public health 1996;4 Suppl():3-5.
1996: Saskia van Acker; D J van den Berg; M N Tromp; D H Griffioen; W P van Bennekom; Wim J F van der Vijgh; Aalt Bast
Structural aspects of antioxidant activity of flavonoids.
Free radical biology & medicine 1996;20(3):331-42.
1996: Saskia van Acker; Klaas Kramer; Emile E Voest; J A Grimbergen; J Zhang; Wim J F van der Vijgh; Aalt Bast
Doxorubicin-induced cardiotoxicity monitored by ECG in freely moving mice. A new model to test potential protectors.
Cancer chemotherapy and pharmacology 1996;38(1):95-101.
1995: Klaas Kramer; Saskia van Acker; J A Grimbergen; D J van den Berg; Wim J F van der Vijgh; Aalt Bast
Effect of dimethyl sulfoxide (DMSO) on the electrocardiogram (ECG) in freely moving male Balb/c mice.
General pharmacology 1995;26(6):1403-7.
1995: Saskia van Acker; M N Tromp; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
Flavonoids as scavengers of nitric oxide radical.
Biochemical and biophysical research communications 1995;214(3):755-9.
1995: GJ Westerveld; R A Scheeren; I Dekker; D H Griffioen; HP Voss; Aalt Bast
Anti-oxidant actions of oxymethazoline and xylomethazoline.
European journal of pharmacology 1995;291(1):27-31.
1995: CH Langeveld; E Schepens; JC Stoof; Aalt Bast; Benjamin Drukarch
Differential sensitivity to hydrogen peroxide of dopaminergic and noradrenergic neurotransmission in rat brain slices.
Free radical biology & medicine 1995;19(2):209-17.
1995: Saskia van Acker; Klaas Kramer; J A Grimbergen; D J van den Berg; Wim J F van der Vijgh; Aalt Bast
Monohydroxyethylrutoside as protector against chronic doxorubicin-induced cardiotoxicity.
British journal of pharmacology 1995;115(7):1260-4.
1995: CH Langeveld; C A M Jongenelen; E Schepens; JC Stoof; Aalt Bast; Benjamin Drukarch
Cultured rat striatal and cortical astrocytes protect mesencephalic dopaminergic neurons against hydrogen peroxide toxicity independent of their effect on neuronal development.
Neuroscience letters 1995;192(1):13-6.
1995: Klaas Kramer; J A Grimbergen; L van der Gracht; D J van Iperen; R J Jonker; Aalt Bast
The use of telemetry to record electrocardiogram and heart rate in freely swimming rats.
Methods and findings in experimental and clinical pharmacology 1995;17(2):107-12.
1995: T L Ching; J G Koelemij; Aalt Bast
The effect of histamine on the oxidative burst of HL60 cells before and after exposure to reactive oxygen species.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1995;44(3):99-104.
1995: G P Biewenga; Aalt Bast
Reaction of lipoic acid with ebselen and hypochlorous acid.
Methods in enzymology 1995;251():303-14.
1995: B C Hüsken; J de Jong; B Beekman; R C A Onderwater; Wim J F van der Vijgh; Aalt Bast
Modulation of the in vitro cardiotoxicity of doxorubicin by flavonoids.
Cancer chemotherapy and pharmacology 1995;37(1-2):55-62.
1994: Martine J Smit; R Leurs; S R Shukrula; Aalt Bast; H Timmerman
Rapid desensitization of the histamine H2 receptor on the human monocytic cell line U937.
European journal of pharmacology 1994;288(1):17-25.
1994: HP Voss; S Shukrula; T S Wu; D Donnell; Aalt Bast
A functional beta-2 adrenoceptor-mediated chronotropic response in isolated guinea pig heart tissue: selectivity of the potent beta-2 adrenoceptor agonist TA 2005.
The Journal of pharmacology and experimental therapeutics 1994;271(1):386-9.
1994: Frank Jansen; T S Wu; HP Voss; H W Steinbusch; R C Vollinga; B Rademaker; Aalt Bast; H Timmerman
Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, [125I]-iodophenpropit, to rat brain.
British journal of pharmacology 1994;113(2):355-62.
1994: Emile E Voest; Saskia van Acker; Wim J F van der Vijgh; B Sweder van Asbeck; Aalt Bast
Comparison of different iron chelators as protective agents against acute doxorubicin-induced cardiotoxicity.
Journal of molecular and cellular cardiology 1994;26(9):1179-85.
1994: G Biewenga; J de Jong; Aalt Bast
Lipoic acid favors thiolsulfinate formation after hypochlorous acid scavenging: a study with lipoic acid derivatives.
Archives of biochemistry and biophysics 1994;312(1):114-20.
1994: T L Ching; J de Jong; Aalt Bast
Structural characteristics of histamine H2 receptor antagonists that scavenge hypochlorous acid.
European journal of pharmacology 1994;268(1):89-93.
1994: HP Voss; R Leurs; D Donnell; Aalt Bast
A new radioligand binding assay for cytochrome P450IID1 (CYP2D1) in rat liver microsomes: a tool to predict sparteine/debrisoquine type polymorphism of drugs.
Journal of pharmacological and toxicological methods 1994;31(3):149-52.
1994: Z Q Yan; K Kramer; Aalt Bast; H Timmerman
The involvement of nitric oxide synthase in the effect of histamine on guinea-pig airway smooth muscle in vitro.
Agents and actions 1994;41 Spec No():C111-2.
1994: T L Ching; J de Jong; Aalt Bast
A method for screening hypochlorous acid scavengers by inhibition of the oxidation of 5-thio-2-nitrobenzoic acid: application to anti-asthmatic drugs.
Analytical biochemistry 1994;218(2):377-81.
1993: Klaas Kramer; Saskia van Acker; HP Voss; J A Grimbergen; Wim J F van der Vijgh; Aalt Bast
Use of telemetry to record electrocardiogram and heart rate in freely moving mice.
Journal of pharmacological and toxicological methods 1993;30(4):209-15.
1993: Martine J Smit; R Leurs; S M Bloemers; Leon Tertoolen; Aalt Bast; SW De Laat; H Timmerman
Extracellular ATP elevates cytoplasmatic free Ca2+ in HeLa cells by the interaction with a 5'-nucleotide receptor.
European journal of pharmacology 1993;247(2):223-6.
1993: Saskia van Acker; Emile E Voest; D B Beems; H T Madhuizen; J de Jong; Aalt Bast; Wim J F van der Vijgh
Cardioprotective properties of O-(beta-hydroxyethyl)-rutosides in doxorubicin-pretreated BALB/c mice.
Cancer research 1993;53(19):4603-7.
1993: Saskia van Acker; L M Koymans; Aalt Bast
Molecular pharmacology of vitamin E: structural aspects of antioxidant activity.
Free radical biology & medicine 1993;15(3):311-28.
1993: J de Jong; P R Schoofs; A M Snabilié; Aalt Bast; W J van der Vijgh
The role of biotransformation in anthracycline-induced cardiotoxicity in mice.
The Journal of pharmacology and experimental therapeutics 1993;266(3):1312-20.
1993: Antonius Marinus ter Laak; G M Donné-Op den Kelder; Aalt Bast; H Timmerman
Is there a difference in the affinity of histamine H1 receptor antagonists for CNS and peripheral receptors? An in vitro study.
European journal of pharmacology 1993;232(2-3):199-205.
1993: T L Ching; Guido R M M Haenen; Aalt Bast
Cimetidine and other H2 receptor antagonists as powerful hydroxyl radical scavengers.
Chemico-biological interactions 1993;86(2):119-27.
1992: A Van der Vliet; Aalt Bast
Effect of oxidative stress on receptors and signal transmission.
Chemico-biological interactions 1992;85(2-3):95-116.
1992: HP Voss; D Donnell; Aalt Bast
Atypical molecular pharmacology of a new long-acting beta 2-adrenoceptor agonist, TA 2005.
European journal of pharmacology 1992;227(4):403-9.
1992: R C Vollinga; Obbe P Zuiderveld; H Scheerens; Aalt Bast; H Timmerman
A simple and rapid in vitro test system for the screening of histamine H3 ligands.
Methods and findings in experimental and clinical pharmacology 1992;14(10):747-51.
1992: Martine J Smit; S M Bloemers; R Leurs; Leon Tertoolen; Aalt Bast; SW De Laat; H Timmerman
Short-term desensitization of the histamine H1 receptor in human HeLa cells: involvement of protein kinase C dependent and independent pathways.
British journal of pharmacology 1992;107(2):448-55.
1992: Frank Jansen; B Rademaker; Aalt Bast; H Timmerman
The first radiolabeled histamine H3 receptor antagonist, [125I]iodophenpropit: saturable and reversible binding to rat cortex membranes.
European journal of pharmacology 1992;217(2-3):203-5.
1992: A Van der Vliet; T J Tuinstra; B Rademaker; Aalt Bast
Role of the epithelium in the control of intestinal motility: implications for intestinal damage after anoxia and reoxygenation.
Agents and actions 1992;36(1-2):159-67.
1992: J J Hageman; Aalt Bast; Nico P E Vermeulen
Monitoring of oxidative free radical damage in vivo: analytical aspects.
Chemico-biological interactions 1992;82(3):243-93.
1992: A van der Vliet; K I van der Poel; Aalt Bast
Intestinal smooth muscle dysfunction after intraperitoneal injection of zymosan in the rat: are oxygen radicals involved?
Gut 1992;33(3):336-41.
1992: R Leurs; M M Brozius; W Jansen; Aalt Bast; H Timmerman
Desensitization of histamine H1 receptor-mediated cyclic GMP production in guinea-pig lung.
European journal of pharmacology 1992;225(2):137-41.
1992: A van der Vliet; Aalt Bast
Role of reactive oxygen species in intestinal diseases.
Free radical biology & medicine 1992;12(6):499-513.
1992: Klaas Kramer; HP Voss; J A Grimbergen; C Smink; H Timmerman; Aalt Bast
Glutathione mobilization during cerebral ischemia and reperfusion in the rat.
General pharmacology 1992;23(1):105-8.
1991: Guido R M M Haenen; Aalt Bast
Scavenging of hypochlorous acid by lipoic acid.
Biochemical pharmacology 1991;42(11):2244-6.
1991: Frederik Pruijn; J P Sibeijn; Aalt Bast
Menadione inhibits the alpha 1-adrenergic receptor-mediated increase in cytosolic free calcium concentration in hepatocytes by inhibiting inositol 1,4,5-trisphosphate-dependent release of calcium from intracellular stores.
Biochemical pharmacology 1991;42(10):1977-86.
1991: Aalt Bast; Guido R M M Haenen; C J Doelman
Oxidants and antioxidants: state of the art.
The American journal of medicine 1991;91(3C):2S-13S.
1991: R Leurs; M M Brozius; W Jansen; Aalt Bast; H Timmerman
Histamine H1-receptor-mediated cyclic GMP production in guinea-pig lung tissue is an L-arginine-dependent process.
Biochemical pharmacology 1991;42(2):271-7.
1991: A Van der Vliet; E M Van der Aar; Aalt Bast
The lipid peroxidation product 4-hydroxy-2,3-trans-1 nonenal decreases rat intestinal smooth muscle function in-vitro by alkylation of sulphydryl groups.
The Journal of pharmacy and pharmacology 1991;43(7):515-7.
1991: A Van der Vliet; Aalt Bast
Hydrogen peroxide reduces beta-adrenoceptor function in the rat small intestine.
European journal of pharmacology 1991;199(2):153-6.
1991: A Donetti; H M Bastiaans; K Kramer; G Bietti; E Cereda; E Dubini; M Mondoni; Aalt Bast; H Timmerman
Substituent effect on the stereochemistry of H2-receptor antagonists of the phenylformamidine series. A conformation-dependent mode of interaction with the H2 receptor.
Journal of medicinal chemistry 1991;34(6):1772-6.
1991: Guido R M M Haenen; Frank Jansen; Nico P E Vermeulen; Aalt Bast
Activation of the microsomal glutathione S-transferase by metabolites of alpha-methyldopa.
Archives of biochemistry and biophysics 1991;287(1):48-52.
1991: R Leurs; Martine J Smit; Aalt Bast; H Timmerman
Homologous histamine H1 receptor desensitization results in reduction of H1 receptor agonist efficacy.
European journal of pharmacology 1991;196(3):319-22.
1991: C J Doelman; R C Sprong; J E Nagtegaal; J F Rodrigues de Miranda; Aalt Bast
Prejunctional muscarinic receptors on cholinergic nerves in guinea pig airways are of the M2 subtype.
European journal of pharmacology 1991;193(1):117-9.
1991: R Leurs; Aalt Bast; H Timmerman
Fluoride is a contractile agent of guinea pig airway smooth muscle.
General pharmacology 1991;22(4):631-6.
1991: R Leurs; Martine J Smit; M M Brozius; W Jansen; Aalt Bast; H Timmerman
Is protein kinase C involved in histamine H1-receptor desensitization?
Agents and actions. Supplements 1991;33():393-402.
1991: R Leurs; M M Brozius; Martine J Smit; Aalt Bast; H Timmerman
Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine.
British journal of pharmacology 1991;102(1):179-85.
1990: R Leurs; Martine J Smit; Aalt Bast; H Timmerman
Different profiles of desensitization dynamics in guinea-pig jejunal longitudinal smooth muscle after stimulation with histamine and methacholine.
British journal of pharmacology 1990;101(4):881-8.
1990: C J Doelman; W C Oosterom; Aalt Bast
Regulation of sympathetic and parasympathetic receptor responses in the rat trachea by epithelium: influence of mechanical and chemical removal of epithelium.
The Journal of pharmacy and pharmacology 1990;42(12):831-6.
1990: Frederik Pruijn; J P Sibeijn; Aalt Bast
Changes in inositol-1,4,5-trisphosphate binding to hepatic plasma membranes caused by temperature, N-ethylmaleimide and menadione.
Biochemical pharmacology 1990;40(9):1947-52.
1990: A Van der Vliet; T J Tuinstra; B Rademaker; Aalt Bast
Intestinal motility disorder induced by peroxides: possible role of lipid peroxidation.
Research communications in chemical pathology and pharmacology 1990;70(2):227-43.
1990: GJ Bijloo; Henk van der Goot; Aalt Bast; H Timmerman
Copper complexes of 1,10-phenanthroline and related compounds as superoxide dismutase mimetics.
Journal of inorganic biochemistry 1990;40(3):237-44.
1990: A van der Vliet; B Rademaker; Aalt Bast
A beta adrenoceptor with atypical characteristics is involved in the relaxation of the rat small intestine.
The Journal of pharmacology and experimental therapeutics 1990;255(1):218-26.
1990: R Leurs; F D Beusenberg; Aalt Bast; J G Van Amsterdam; H Timmerman
Identification of beta 2-adrenoceptors on guinea pig alveolar macrophages using (-)-3-[125I]iodocyanopindolol.
Inflammation 1990;14(4):421-6.
1990: R Leurs; Aalt Bast; H Timmerman
Ebselen inhibits contractile responses of guinea-pig parenchymal lung strips.
European journal of pharmacology 1990;179(1-2):193-9.
1990: R Leurs; Aalt Bast; H Timmerman
Essential thiol and disulphide groups in the histamine H1-receptor signal transfer of guinea-pig parenchymal lung strips.
Agents and actions 1990;30(1-2):169-73.
1990: Aalt Bast; A J Valk; H Timmerman
Cytochrome P-450 metabolic-intermediate complex formation with a series of diphenhydramine analogues.
Agents and actions 1990;30(1-2):161-5.
1990: R Leurs; Aalt Bast; H Timmerman
Labelling of non-H1-receptor binding sites by [3H]-mepyramine on the rat liver plasma membrane.
Agents and actions 1990;30(1-2):157-60.
1990: H M Bastiaans; A Donetti; K Kramer; G Bietti; E Cereda; D Dubini; M Mondini; Aalt Bast; H Timmerman
Irreversible H2-antagonism of the four isomeric butyl analogues of mifentidine.
Agents and actions 1990;30(1-2):166-8.
1990: A van der Vliet; Aalt Bast; H Timmerman
Autoinhibition of histamine release by H3 receptors in rat brain cortex depends on stimulation frequency.
Agents and actions 1990;30(1-2):206-9.
1990: C J Doelman; Paul J A Borm; Aalt Bast
Plasticisers and bronchial hyperreactivity.
Lancet 1990;335(8691):725.
1990: Guido R M M Haenen; B M De Rooij; Nico P E Vermeulen; Aalt Bast
Mechanism of the reaction of ebselen with endogenous thiols: dihydrolipoate is a better cofactor than glutathione in the peroxidase activity of ebselen.
Molecular pharmacology 1990;37(3):412-22.
1990: R Leurs; J N Go; Aalt Bast; H Timmerman
Desensitization of guinea-pig parenchymal lung strips after prolonged histamine H1-receptor stimulation.
Archives internationales de pharmacodynamie et de thérapie 1990;304():265-76.
1990: C J Doelman; R Leurs; W C Oosterom; Aalt Bast
Mineral dust exposure and free radical-mediated lung damage.
Experimental lung research 1990;16(1):41-55.
1990: E Rekka; R M Mannhold; Aalt Bast; H Timmerman
Molecular pharmacological aspects of antiarrhythmic activity. I. Class I and class III compounds and lipid peroxidation.
Biochemical pharmacology 1990;39(1):95-100.
1990: C J Doelman; Aalt Bast
Pro- and anti-oxidant factors in rat lung cytosol.
Advances in experimental medicine and biology 1990;264():455-61.
1990: Aalt Bast; Guido R M M Haenen
Regulation of lipid peroxidation by glutathione and lipoic acid: involvement of liver microsomal vitamin E free radical reductase.
Advances in experimental medicine and biology 1990;264():111-6.
1990: C J Doelman; P J Borm; Aalt Bast
Plasticisers, another burden for asthmatics?
Agents and actions. Supplements 1990;31():81-4.
1990: Guido R M M Haenen; M Veerman; Aalt Bast
Reduction of beta-adrenoceptor function by oxidative stress in the heart.
Free radical biology & medicine 1990;9(4):279-88.
1990: C J Doelman; J F de Vlieger; R C Sprong; Aalt Bast
Oxidative stress and receptor responses in guinea-pig tracheal tissue.
Agents and actions. Supplements 1990;31():143-5.
1990: C J Doelman; Aalt Bast
Oxygen radicals in lung pathology.
Free radical biology & medicine 1990;9(5):381-400.
1989: A van der Vliet; T J Tuinstra; Aalt Bast
Modulation of oxidative stress in the gastrointestinal tract and effect on rat intestinal motility.
Biochemical pharmacology 1989;38(17):2807-18.
1989: Guido R M M Haenen; B M de Rooij; H Timmerman; Aalt Bast
Beta-adrenoceptor agonists do not reduce hydrogen peroxide production from superoxide radicals.
Archives internationales de pharmacodynamie et de thérapie 1989;300():68-75.
1989: R Leurs; Aalt Bast; H Timmerman
High affinity, saturable [3H]mepyramine binding sites on rat liver plasma membrane do not represent histamine H1-receptors. A warning.
Biochemical pharmacology 1989;38(13):2175-80.
1989: R Leurs; D Donnell; H Timmerman; Aalt Bast
Interaction of nefopam and orphenadrine with the cytochrome P-450 and the glutathione system in rat liver.
The Journal of pharmacy and pharmacology 1989;41(6):388-93.
1989: E Rekka; H Timmermann; Aalt Bast
Structural features of some diphenhydramine analogues that determine the interaction with rat liver cytochrome P-450.
Agents and actions 1989;27(1-2):184-7.
1989: R Leurs; J N Go; Aalt Bast; H Timmerman
Involvement of protein kinase C in the histamine H1-receptor mediated contraction of guinea-pig lung parenchymal strips.
Agents and actions 1989;27(1-2):180-3.
1989: Aalt Bast; Kees Smid; H Timmerman
The effects of cimetidine, ranitidine and famotidine on rat hepatic microsomal cytochrome P-450 activities.
Agents and actions 1989;27(1-2):188-91.
1989: R Leurs; H Timmerman; Aalt Bast
Inhibition of superoxide anion radical production by ebselen (PZ51) and its sulfur analogue (PZ25) in guinea pig alveolar macrophages.
Biochemistry international 1989;18(2):295-9.
1989: Guido R M M Haenen; Nico P E Vermeulen; H Timmerman; Aalt Bast
Effect of thiols on lipid peroxidation in rat liver microsomes.
Chemico-biological interactions 1989;71(2-3):201-12.
1989: Guido R M M Haenen; H J Plug; Nico P E Vermeulen; H Timmerman; Aalt Bast
Contribution of 4-hydroxy-2,3-trans-nonenal to the reduction of beta-adrenoceptor function in the heart by oxidative stress.
Life sciences 1989;45(1):71-6.
1989: Frederik Pruijn; J G van Gelderen; Aalt Bast
The effects of radical stress and N-ethylmaleimide on rat hepatic alpha 1-adrenergic receptors.
Toxicology letters 1989;45(1):73-82.
1988: Aalt Bast; Guido R M M Haenen
Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation.
Biochimica et biophysica acta 1988;963(3):558-61.
1988: A R Goeptar; Guido R M M Haenen; H Timmerman; Aalt Bast
The effects of beta-adrenergic receptor agonists on the H2O2 formation in alveolar macrophage suspensions are not mediated by beta-receptors.
Agents and actions 1988;25(3-4):375-7.
1988: A Van der Vliet; J F Van der Werf; Aalt Bast; H Timmerman
Frequency-dependent autoinhibition of histamine release from rat cortical slices: a possible role for H3 receptor reserve.
The Journal of pharmacy and pharmacology 1988;40(8):577-9.
1988: C J Doelman; Klaas Kramer; H Timmerman; Aalt Bast
Vitamin E and selenium regulate balance between beta-adrenergic and muscarinic responses in rat lungs.
FEBS letters 1988;233(2):427-31.
1988: E Rekka; G J Sterk; H Timmerman; Aalt Bast
Identification of structural characteristics of some potential H2-receptor antagonists that determine the interaction with rat hepatic P-450.
Chemico-biological interactions 1988;67(1-2):117-27.
1988: Guido R M M Haenen; P Van Dansik; Nico P E Vermeulen; H Timmerman; Aalt Bast
The effect of hydrogen peroxide on beta-adrenoceptor function in the heart.
Free radical research communications 1988;4(4):243-9.
1987: Klaas Kramer; HP Voss; J A Grimbergen; H Timmerman; Aalt Bast
The effect of ischemia and recirculation, hypoxia and recovery on anti-oxidant factors and beta-adrenoceptor density. Is the damage in the erythrocytes a reflection of brain damage caused by complete cerebral ischemia and by hypoxia?
Biochemical and biophysical research communications 1987;149(2):568-75.
1987: Guido R M M Haenen; J N Tai Tin Tsoi; Nico P E Vermeulen; H Timmerman; Aalt Bast
4-Hydroxy-2,3-trans-nonenal stimulates microsomal lipid peroxidation by reducing the glutathione-dependent protection.
Archives of biochemistry and biophysics 1987;259(2):449-56.
1987: R Leurs; D Donnell; H Timmerman; Aalt Bast
Cytochrome P450 metabolic intermediate complex of nefopam.
The Journal of pharmacy and pharmacology 1987;39(10):835-7.
1987: J F Van der Werf; Aalt Bast; G J Bijloo; A Van der Vliet; H Timmerman
HA autoreceptor assay with superfused slices of rat brain cortex and electrical stimulation.
European journal of pharmacology 1987;138(2):199-206.
1987: Klaas Kramer; C J Doelman; H Timmerman; Aalt Bast
A disbalance between beta-adrenergic and muscarinic responses caused by hydrogen peroxide in rat airways in vitro.
Biochemical and biophysical research communications 1987;145(1):357-62.
1987: J F van der Werf; G J Bijloo; A van der Vliet; Aalt Bast; H Timmerman
H3 receptor assay in electrically-stimulated superfused slices of rat brain cortex; effects of N alpha-alkylated histamines and impromidine analogues.
Agents and actions 1987;20(3-4):239-43.