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Jacopo Mariotti

Research Profile

Disorders

Graft vs Host Disease

Living Beings

Procedures

Chemicals & Drugs

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Physiology

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Publications

TOP 3
Daniel H Fowler; Juan Gea-Banacloche; Andre Goy; Ronald E Gress; Frances T Hakim; David C Halverson; Nancy M Hardy; Dennis D Hickstein; Carl H June; Hanh M Khuu; Robert Korngold; Susan F Leitman; Bruce L Levine; Jacopo Mariotti; Miriam Mossoba; Steven Z Pavletic; Andrew L Pecora; Scott Rowley; Marianna Sabatino; Claude Sportes; Seth M Steinberg; David Stroncek; Luciano Castiello; Michele Donato; Michael Bishop
Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation.
Arian Dominic John laurence; Jacopo Mariotti; John J O'Shea; Yong Chan Kim; Shoba Amarnath; Michael Eckhaus; Jason Foley; Daniel H Fowler
STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.
Jacopo Mariotti; Justin Taylor; Paul R Massey; Kaitlyn Ryan; Jason Foley; Nicole Buxhoeveden; Tania C Felizardo; Shoba Amarnath; Miriam Mossoba; Daniel H Fowler
The pentostatin plus cyclophosphamide nonmyeloablative regimen induces durable host T cell functional deficits and prevents murine marrow allograft rejection.

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All Publications

2013: Daniel H Fowler; Juan Gea-Banacloche; Andre Goy; Ronald E Gress; Frances T Hakim; David C Halverson; Nancy M Hardy; Dennis D Hickstein; Carl H June; Hanh M Khuu; Robert Korngold; Susan F Leitman; Bruce L Levine; Jacopo Mariotti; Miriam Mossoba; Steven Z Pavletic; Andrew L Pecora; Scott Rowley; Marianna Sabatino; Claude Sportes; Seth M Steinberg; David Stroncek; Luciano Castiello; Michele Donato; Michael Bishop
Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation.
Blood 2013;121(15):2864-74.
2012: Arian Dominic John laurence; Jacopo Mariotti; John J O'Shea; Yong Chan Kim; Shoba Amarnath; Michael Eckhaus; Jason Foley; Daniel H Fowler
STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.
Immunity 2012;37(2):209-22.
2011: Jacopo Mariotti; Justin Taylor; Paul R Massey; Kaitlyn Ryan; Jason Foley; Nicole Buxhoeveden; Tania C Felizardo; Shoba Amarnath; Miriam Mossoba; Daniel H Fowler
The pentostatin plus cyclophosphamide nonmyeloablative regimen induces durable host T cell functional deficits and prevents murine marrow allograft rejection.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2011;17(5):620-31.
2010: Shoba Amarnath; Carliann M Costanzo; Michael Eckhaus; Francis A Flomerfelt; Jason E Foley; Anu Gangopadhyay; Carl H June; Daniel M Konecki; Bruce L Levine; Jacopo Mariotti; Susan Wong; Daniel H Fowler
Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD.
Autophagy 2010;6(4):523-41.
2010: Shoba Amarnath; Carliann M Costanzo; Jacopo Mariotti; Jessica L Ullman; William G Telford; Veena Kapoor; James L Riley; Bruce L Levine; Carl H June; Timothy Fong; Noel L Warner; Daniel H Fowler
Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.
PLoS biology 2010;8(2):e1000302.
2009: Courtney A Granville; Regan M Memmott; Andria Balogh; Jacopo Mariotti; Shigeru Kawabata; Wei Han; Jaclyn LoPiccolo; Jason Foley; David J Liewehr; Seth M Steinberg; Daniel H Fowler; M Christine Hollander; Phillip A Dennis
A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.
PloS one 2009;4(3):e5061.
2008: Jacopo Mariotti; Jason Foley; Kaitlyn Ryan; Nicole Buxhoeveden; Veena Kapoor; Shoba Amarnath; Daniel H Fowler
Graft rejection as a Th1-type process amenable to regulation by donor Th2-type cells through an interleukin-4/STAT6 pathway.
Blood 2008;112(12):4765-75.
2008: Jason E Foley; Jacopo Mariotti; Kaitlyn Ryan; Michael Eckhaus; Daniel H Fowler
Th2 cell therapy of established acute graft-versus-host disease requires IL-4 and IL-10 and is abrogated by IL-2 or host-type antigen-presenting cells.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008;14(9):959-72.
2008: Jacopo Mariotti; Jason Foley; Unsu Jung; Todd Borenstein; Nermina Kantardzic; Soo Han; Joshua T Hanson; Elaine Wong; Nicole Buxhoeveden; Jane Trepel; Antonio Tito Fojo; William G Telford; Daniel H Fowler
Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):89-105.
2006: Unsu Jung; Jason E Foley; Andreas A Erdmann; Yoko Toda; Todd Borenstein; Jacopo Mariotti; Daniel H Fowler
Ex vivo rapamycin generates Th1/Tc1 or Th2/Tc2 Effector T cells with enhanced in vivo function and differential sensitivity to post-transplant rapamycin therapy.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(9):905-18.
2005: Jason E Foley; Unsu Jung; Angel Miera; Todd Borenstein; Jacopo Mariotti; Michael Eckhaus; Barbara E Bierer; Daniel H Fowler
Ex vivo rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5732-43.