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Hon Fong Mark

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TOP 3
Hon Fong L Mark
Dr. R. J. McKinlay Gardner Interviewed by Dr. Hon Fong L. Mark.
Edgar A Sotomayor; Inangati M Shah; Warren G Sanger; Hon Fong L Mark
In situ follicular lymphoma with a 14;18 translocation diagnosed by a multimodal approach.
Búrix Mechoso; Alicia Vaglio; Andrea Quadrelli; Hon Fong L Mark; Xin-Li Huang; Aubrey Milunsky; Roberto Quadrelli
A de novo complex chromosome rearrangement involving chromosomes 2, 3, 5, 9 and 11 detected prenatally and studied postnatally by conventional cytogenetics and molecular cytogenetic analyses.

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All Publications

2008: Hon Fong L Mark
Dr. R. J. McKinlay Gardner Interviewed by Dr. Hon Fong L. Mark.
Journal of the Association of Genetic Technologists 2008;34(1):9-10.
2007: Edgar A Sotomayor; Inangati M Shah; Warren G Sanger; Hon Fong L Mark
In situ follicular lymphoma with a 14;18 translocation diagnosed by a multimodal approach.
Experimental and molecular pathology 2007;83(2):254-8.
2007: Búrix Mechoso; Alicia Vaglio; Andrea Quadrelli; Hon Fong L Mark; Xin-Li Huang; Aubrey Milunsky; Roberto Quadrelli
A de novo complex chromosome rearrangement involving chromosomes 2, 3, 5, 9 and 11 detected prenatally and studied postnatally by conventional cytogenetics and molecular cytogenetic analyses.
Fetal diagnosis and therapy 2007;22(4):249-53.
2006: Hon Fong L Mark; Edgar A Sotomayor; Marilu Nelson; Fernando Chaves; Warren G Sanger; Zahid Kaleem; Samuel K Caughron
Chronic idiopathic myelofibrosis (CIMF) resulting from a unique 3;9 translocation disrupting the janus kinase 2 (JAK2) gene.
Experimental and molecular pathology 2006;81(3):217-23.
2006: Cynthia C Hayne; Eric Winer; Tara Williams; Fernando Chaves; Jila Khorsand; Hon Fong L Mark
Acute lymphoblastic leukemia with 4;11 translocation analyzed by a multi-modal strategy of conventional cytogenetics, FISH, morphology, flow cytometry and molecular genetics, and review of the literature.
Experimental and molecular pathology 2006;81(1):62-71.
2006: Hon Fong L Mark; Robert A Sokolic; Yvonne Mark
Conventional cytogenetics and FISH in the detection of BCR/ABL fusion in chronic myeloid leukemia (CML).
Experimental and molecular pathology 2006;81(1):1-7.
2006: Herman E Wyandt; Sung Han Shim; Hon Fong L Mark; Xin Li Huang; Jeff M Milunsky
Duplication of 11p14.3-p15.1 in a mentally retarded proband and his mother detected by G-banding and confirmed by high-resolution CGH and BAC FISH.
Experimental and molecular pathology 2006;80(3):262-6.
2006: Vijay S Tonk; Golder Wilson; Robert Schutt; Justin Mock; Herman E Wyandt; Hon Fong L Mark; Masamichi Ito
Costovertebral dysplasia in a patient with partial trisomy 22.
Experimental and molecular pathology 2006;80(2):197-200.
2005: Xin Li Huang; M I de Michelena; Hon Fong L Mark; R Harston; P J Benke; S J Price; Aubrey Milunsky
Characterization of an analphoid supernumerary marker chromosome derived from 15q25-->qter using high-resolution CGH and multiplex FISH analyses.
Clinical genetics 2005;68(6):513-9.
2005: Hon Fong L Mark; Herman E Wyandt; Agen Pan; Jeff M Milunsky
Constitutional partial 1q trisomy mosaicism and Wilms tumor.
Cancer genetics and cytogenetics 2005;162(2):166-71.
2005: Hon Fong L Mark; Herman E Wyandt; Xin Li Huang; Jeff M Milunsky
Delineation of a supernumerary marker chromosome utilizing a multimodal approach of G-banding, fluorescent in situ hybridization, confirmatory P1 artificial chromosome fluorescent in situ hybridization, and high-resolution comparative genomic hybridization.
Clinical genetics 2005;68(2):146-51.
2000: Hon Fong L Mark; R Caldarone; A Colt; Samara I Viner-Brown; A Zimmerman; Peter Simon
Public health genetics in Rhode Island: first steps.
Medicine and health, Rhode Island 2000;83(6):191-2.
2000: Elaine L Bearer; Arthur F Chen; AH Chen; Z Li; Hon Fong L Mark; Richard J H Smith; C L Jackson
2E4/Kaptin (KPTN)--a candidate gene for the hearing loss locus, DFNA4.
Annals of human genetics 2000;64(Pt 3):189-96.
2000: Hon Fong L Mark; H Bai; Edgar A Sotomayor; S Mark; P Rintels
Hypotetraploidy in a patient with small cell carcinoma.
Experimental and molecular pathology 2000;68(1):70-6.
2000: Hon Fong L Mark; M Samy; K Santoro; S Mark; D Feldman
Fluorescent in situ hybridization study of c-myc oncogene copy number in prostate cancer.
Experimental and molecular pathology 2000;68(1):65-9.
2000: Diane L Persons; Marilyn M Bui; M C Lowery; Hon Fong L Mark; J F Yung; J M Birkmeier; E Y Wong; S J Yang; Shahla Masood
Fluorescence in situ hybridization (FISH) for detection of HER-2/neu amplification in breast cancer: a multicenter portability study.
Annals of clinical and laboratory science 2000;30(1):41-8.
1999: Robert A Sokolic; William Shay Ferguson; Hon Fong L Mark
Discordant detection of monosomy 7 by GTG-banding and FISH in a patient with Shwachman-Diamond syndrome without evidence of myelodysplastic syndrome or acute myelogenous leukemia.
Cancer genetics and cytogenetics 1999;115(2):106-13.
1999: Hon Fong L Mark; D Feldman; S Das; M Samy; CL Sun; S Mark
Assessment of chromosomal trisomies in prostate cancer using fluorescent in situ hybridization.
Experimental and molecular pathology 1999;67(2):109-17.
1999: Hon Fong L Mark; M Sigman
Male infertility associated with a unique 8;22 translocation.
Experimental and molecular pathology 1999;67(1):57-61.
1999: Hon Fong L Mark; H Bai; Edgar A Sotomayor; S Mark; K Zolnierz; E Airall; M Sigman
A variant Klinefelter syndrome patient with an XXY/XX/XY karyotype studied by GTG-banding and fluorescence in situ hybridization.
Experimental and molecular pathology 1999;67(1):50-6.
1999: Hon Fong L Mark; Edgar A Sotomayor; Anthony E Mega
Occurrence of both t(1;19) and t(8;14) in a patient with chronic lymphocytic leukemia.
Experimental and molecular pathology 1999;66(3):238-42.
1999: Hon Fong L Mark; D Feldman; S Das; H Kye; S Mark; CL Sun; M Samy
Fluorescence in situ hybridization study of HER-2/neu oncogene amplification in prostate cancer.
Experimental and molecular pathology 1999;66(2):170-8.
1999: Alaa M Afify; Bruce A Werness; Hon Fong L Mark
HER-2/neu oncogene amplification in stage I and stage III ovarian papillary serous carcinoma.
Experimental and molecular pathology 1999;66(2):163-9.
1999: Hon Fong L Mark; D Feldman; M Samy; C Sun; S Das; S Mark; JC Lathrop
Assessment of chromosome 8 copy number in cervical cancer by fluorescent in situ hybridization.
Experimental and molecular pathology 1999;66(2):157-62.
1999: Hon Fong L Mark
Conventional and molecular cytogenetics in medicine.
Medicine and health, Rhode Island 1999;82(5):160-3.
1999: Hon Fong L Mark; Alaa M Afify; Bruce A Werness; S Das; S Mark; M Samy
Trisomy 8 in stage I and stage III ovarian cancer detected by fluorescence in situ hybridization.
Experimental and molecular pathology 1999;66(1):76-81.
1999: Hon Fong L Mark; B Aswad; N Bassily; W Taylor; S Brown; CL Sun; M Samy; K Zolnierz; E Wong; KI Bland; P H Hsu
HER-2/neu gene amplification in stages I-IV breast cancer detected by fluorescent in situ hybridization.
Genetics in medicine : official journal of the American College of Medical Genetics 1999;1(3):98-103.
1999: Hon Fong L Mark; D Alter; P Mousseau
Klinefelter syndrome.
Archives of pathology & laboratory medicine 1999;123(3):261.
1999: Hon Fong L Mark; Y Gray; Edgar A Sotomayor; P Joseph
Trisomy 9 in a patient with secondary acute myelogenous leukemia detected by fluorescent in situ hybridization.
Pathobiology : journal of immunopathology, molecular and cellular biology 1999;67(2):111-4.
1999: Hon Fong L Mark; Y Gray; Yvonne Mark; J Khorsand; W Sikov
A multimodal approach in the diagnosis of patients with hematopoietic disorders.
Cancer genetics and cytogenetics 1999;109(1):14-20.
1999: O Estalilla; P Rintels; Hon Fong L Mark
Trisomy 10 as a sole chromosomal abnormality in AML-M2.
Cancer genetics and cytogenetics 1999;108(2):175.
1999: Alaa M Afify; Hon Fong L Mark
Trisomy 8 in embryonal rhabdomyosarcoma detected by fluorescence in situ hybridization.
Cancer genetics and cytogenetics 1999;108(2):127-32.
1999: Hon Fong L Mark; D Feldman; S Das; CL Sun; M Samy; JC Lathrop
HER-2/neu oncogene amplification in cervical cancer studied by fluorescent in situ hybridization.
Genetic testing 1999;3(2):237-42.
1999: Hon Fong L Mark; S Brown; W Taylor; N Bassily; CL Sun; M Samy; KI Bland
Study of chromosome 12 copy number in breast cancer using fluorescence in situ hybridization.
Cancer genetics and cytogenetics 1999;108(1):26-31.
1999: Hon Fong L Mark; W Taylor; S Brown; M Samy; CL Sun; K Santoro; KI Bland
Abnormal chromosome 8 copy number in stage I to stage IV breast cancer studied by fluorescence in situ hybridization.
Cancer genetics and cytogenetics 1999;108(1):1-5.
1999: Hon Fong L Mark; D Feldman; M Sigman
Conventional and molecular cytogenetic identification of a variant klinefelter syndrome patient with a deleted X chromosome.
Pathobiology : journal of immunopathology, molecular and cellular biology 1999;67(1):55-8.
1998: Hon Fong L Mark; D N Alter; Anthony E Mega
FISH as an adjunct to conventional cytogenetics.
Medicine and health, Rhode Island 1998;81(10):328-30.
1998: Shahla Masood; Marilyn M Bui; J F Yung; Hon Fong L Mark; E Y Wong; J M Birkmeier; S J Yang; P Hsu
Reproducibility of LSI HER-2/neu SpectrumOrange and CEP 17 SpectrumGreen Dual Color deoxyribonucleic acid probe kit. For enumeration of gene amplification in paraffin-embedded specimens: a multicenter clinical validation study.
Annals of clinical and laboratory science 1998;28(4):215-23.
1998: Hon Fong L Mark; M McCarthy; D Berry
Advances in breast cancer genetics.
Medicine and health, Rhode Island 1998;81(5):183-6.
1998: Hon Fong L Mark; J Rehan; S Mark; K Santoro; K Zolnierz
Fluorescence in situ hybridization analysis of single-cell trisomies for determination of clonality.
Cancer genetics and cytogenetics 1998;102(1):1-5.
1998: Hon Fong L Mark; L Wells
A laboratorian's view on the College of American Pathologists' Laboratory Accreditation Program for Clinical Laboratories.
Annals of clinical and laboratory science 1998;28(2):115-23.
1998: O Estalilla; P Rintels; Hon Fong L Mark
Trisomy 10 in leukemia.
Cancer genetics and cytogenetics 1998;101(1):68-71.
1998: Hon Fong L Mark; M E Rausch; W M Taylor; A Huth; S Mark; K Santoro; K Zolnierz; K Ferreira; B E Barker
Sequential flow cytometry and fluorescence in situ hybridization for the study of formalin-fixed, paraffin-embedded breast cancer cells.
Cancer genetics and cytogenetics 1998;100(2):129-33.
1998: Hon Fong L Mark; Yvonne Mark; Edgar A Sotomayor; Sundaresan Sambandam
A patient with myelodysplastic syndrome studied by GTG-banding and fluorescent in situ hybridization (FISH).
Cytobios 1998;94(376):121-8.
1998: Hon Fong L Mark; J J Przygoda; W Sikov
Fluorescent in situ hybridization for identifying cytogenetic abnormalities in inadequate and suboptimal specimens.
Pathobiology : journal of immunopathology, molecular and cellular biology 1998;66(5):216-20.
1998: Hon Fong L Mark; S Brown; CL Sun; M Samy; Alaa M Afify
Fluorescent in situ hybridization detection of HER-2/neu gene amplification in rhabdomyosarcoma.
Pathobiology : journal of immunopathology, molecular and cellular biology 1998;66(2):59-63.
1997: Hon Fong L Mark; Alaa M Afify; W Taylor; K Santoro; JC Lathrop
A subset of gestational trophoblastic disease characterized by abnormal chromosome 8 copy number detected by fluorescence in situ hybridization.
Cancer genetics and cytogenetics 1997;99(1):24-9.
1997: Alaa M Afify; Hon Fong L Mark
Fluorescence in situ hybridization assessment of chromosome 8 copy number in stage I and stage II infiltrating ductal carcinoma of the breast.
Cancer genetics and cytogenetics 1997;97(2):101-5.
1997: Hon Fong L Mark; J A Bier
Disappearing trisomy 8 mosaicism.
Annals of clinical and laboratory science 1997;27(4):293-8.
1997: Hon Fong L Mark; DR Mills; K Santoro; M R Quddus; JC Lathrop
Fluorescent in situ hybridization analysis of cervical smears. A pilot study of 20 cases.
Annals of clinical and laboratory science 1997;27(3):224-9.
1997: S S Chang; Hon Fong L Mark
Emerging molecular cytogenetic technologies.
Cytobios 1997;90(360):7-22.
1997: Hon Fong L Mark; Y Gray; P Rintels
Translocation 2;19 in a patient with probable relapsed acute myeloid leukemia.
Pathobiology : journal of immunopathology, molecular and cellular biology 1997;65(4):223-8.
1997: Hon Fong L Mark; W Taylor; Alaa M Afify; D Riera; M Rausch; A Huth; Y Gray; K Santoro; KI Bland
Stage I and stage II infiltrating ductal carcinoma of the breast analyzed for chromosome 8 copy number using fluorescent in situ hybridization.
Pathobiology : journal of immunopathology, molecular and cellular biology 1997;65(4):184-9.
1997: Hon Fong L Mark; R Jenkins; W A Miller
Current applications of molecular cytogenetic technologies.
Annals of clinical and laboratory science 1997;27(1):47-56.
1996: M V Nebres; Hon Fong L Mark
Breast cancer among Asian women.
Medicine and health, Rhode Island 1996;79(11):388-91.
1996: Hon Fong L Mark
The detection of translocations using chromosome painting for monitoring exposure to potential genotoxicants.
Medicine and health, Rhode Island 1996;79(9):333-5.
1996: Hon Fong L Mark; G Annas; R Ricker; Jeffrey N Weitzel
Clinical and research issues in breast cancer genetics.
Annals of clinical and laboratory science 1996;26(5):396-408.
1996: Hon Fong L Mark; I Hanna; Douglas R Gnepp
Cytogenetic analysis of salivary gland type tumors.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 1996;82(2):187-92.
1996: C Young; J Di Benedetto; L Glasser; Hon Fong L Mark
A Philadelphia chromosome positive CML patient with a unique translocation studied via GTG-banding and fluorescence in situ hybridization.
Cancer genetics and cytogenetics 1996;89(2):157-62.
1996: Hon Fong L Mark; J A Bier; P Scola
The frequency of chromosomal abnormalities in patients referred for fragile X analysis.
Annals of clinical and laboratory science 1996;26(4):323-8.
1996: Hon Fong L Mark; R Naram; J Singer; R Rice; P H LaMarche
Douglas-fir: a third wood-drying condensate found to exhibit in vitro cytotoxicity and genotoxicity.
Annals of clinical and laboratory science 1996;26(3):269-74.
1996: C D Wu; L J Medeiros; R N Miranda; Hon Fong L Mark; P Rintels
Chronic myeloid leukemia manifested during megakaryoblastic crisis.
Southern medical journal 1996;89(4):422-7.
1996: Hon Fong L Mark; K Santoro; W Campbell; E Hann; JC Lathrop
Integration of human papillomavirus sequences in cervical tumor cell lines.
Annals of clinical and laboratory science 1996;26(2):147-53.
1996: Hon Fong L Mark; JC Lathrop
Cytogenetics in obstetrics and gynecology.
Medicine and health, Rhode Island 1996;79(2):55-7.
1996: Hon Fong L Mark; KI Bland
Laboratory study of breast cancer using conventional and molecular cytogenetics.
Medicine and health, Rhode Island 1996;79(2):50-4.
1996: Hon Fong L Mark; J K Bayleran; David B Seifer; C H Meyers-Seifer
A combined cytogenetic and molecular approach for diagnosing delayed puberty.
Clinical pediatrics 1996;35(2):62-6.
1996: Hon Fong L Mark; E Prence; L Beauregard; R Greenstein
The impact of managed care on genetic testing laboratories in the United States.
Cytobios 1996;88(352):43-52.
1996: Hon Fong L Mark; K D McGowan
Issues in the genetic assessment of predispositions for familial breast and ovarian cancer.
Cytobios 1996;87(351):229-35.
1996: Hon Fong L Mark; D R Mills; E Kim; K Santoro; M R Quddus; JC Lathrop
Fluorescent in situ hybridization assessment of chromosome copy number in buccal mucosal cells.
Cytobios 1996;87(349):117-26.
1996: Hon Fong L Mark; Y H Dong; E Forman; P Smith; L Glasser
A multimodal approach for diagnosing patients with acute promyelocytic leukaemia.
Cytobios 1996;87(350):137-49.
1996: Alaa M Afify; KI Bland; Hon Fong L Mark
Fluorescent in situ hybridization assessment of chromosome 8 copy number in breast cancer.
Breast cancer research and treatment 1996;38(2):201-8.
1996: Hon Fong L Mark; R Naram; J T Singer; R W Rice; W C Bastan; L J Beauregard; P H Lamarche
Wood-drying condensate from Eastern white pine induced cytotoxicity and genotoxicity in vitro.
Annals of clinical and laboratory science 1996;26(1):64-70.
1995: Hon Fong L Mark; B K Chow
Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry.
Genomics 1995;29(3):817-8.
1995: Hon Fong L Mark; T Kelly; M S Watson; G Hoeltge; W A Miller; L Beauregard
Current issues of personnel and laboratory practices in genetic testing.
Journal of medical genetics 1995;32(10):780-6.
1995: Hon Fong L Mark; C H Meyers-Seifer; David B Seifer; B M Demoranville; I M Jackson
Assessment of sex chromosome composition using fluorescent in situ hybridization as an adjunct to GTG-banding.
Annals of clinical and laboratory science 1995;25(5):402-8.
1995: Hon Fong L Mark; William Sikov; Howard Safran; T C King; R C Griffith
Fluorescent in situ hybridization for assessing the proportion of cells with trisomy 4 in a patient with acute non-lymphoblastic leukemia.
Annals of clinical and laboratory science 1995;25(4):330-5.
1995: Hon Fong L Mark; MG Grollino; R A Sulaiman; JC Lathrop
Fluorescent in situ hybridization assessment of chromosome copy number in gestational trophoblastic disease.
Annals of clinical and laboratory science 1995;25(4):291-6.
1995: Hon Fong L Mark; R Naram; J T Singer; R W Rice; B Bastan; L J Beauregard; P H LaMarche
Cytotoxicity and genotoxicity of wood drying condensate from Southern Yellow Pine: an in vitro study.
Mutation research 1995;342(3-4):191-6.
1995: Dianne Abuelo; Hon Fong L Mark; J A Bier
Developmental delay caused by a supernumerary chromosome, inv dup (15), identified by fluorescent in situ hybridization.
Clinical pediatrics 1995;34(4):223-6.
1995: Hon Fong L Mark; E Hann; R Mikumo; Stuart C Lauchlan; L Beauregard; L Braun
Cytogenetic characterization of three cell lines derived from primary cervical tumors.
Annals of clinical and laboratory science 1995;25(2):185-99.
1995: Hon Fong L Mark; R Naram; W C Bastan; J K Cherkes; P H LaMarche
Red oak condensate: its apparent lack of cytotoxic and genotoxic effects as compared with three other wood-drying condensates.
Cytobios 1995;84(338-339):133-40.
1995: Hon Fong L Mark; R Naram; K Santoro; KI Bland
A study of induced genotoxicity in MCF-7 cells.
Cytobios 1995;84(338-339):171-7.
1995: Hon Fong L Mark; R Naram; J T Singer; R W Rice; B Bastan; L J Beauregard; P H LaMarche
Eastern white pine wood-drying condensate induced cytotoxicity and genotoxicity in human peripheral blood lymphocytes in vitro.
Cytobios 1995;83(332):25-31.
1995: Hon Fong L Mark; M Sheu; L Lopes; J Campagnone; K Takezawa; K Santoro; M Sigman
Towards the development of a fluorescent in situ hybridization based genotoxicologic assay for aneuploidy detection in sperm.
Cytobios 1995;82(330):171-80.
1994: R N Miranda; Hon Fong L Mark; L J Medeiros
Fluorescent in situ hybridization in routinely processed bone marrow aspirate clot and core biopsy sections.
The American journal of pathology 1994;145(6):1309-14.
1994: Hon Fong L Mark; Douglas R Gnepp; P Nigri; W Campbell; Y Mark
Combined strategy of conventional cytogenetics, fluorescent in situ hybridization and chromosome morphometry for analysis of parotid gland tumor.
Annals of clinical and laboratory science 1994;24(6):555-9.
1994: Hon Fong L Mark
Recent advances in molecular cytogenetics: fluorescent in situ hybridization.
Rhode Island medicine 1994;77(11):377-81.
1994: Hon Fong L Mark; R Naram; T Pham; K Shah; L P Cousens; C Wiersch; E Airall; M Samy; K Zolnierz; R Mark
A practical cytogenetic protocol for in vitro cytotoxicity and genotoxicity testing.
Annals of clinical and laboratory science 1994;24(5):387-95.
1994: R N Miranda; Hon Fong L Mark; C E Oyer
Sudden infant death syndrome (SIDS)
Pediatric pathology / affiliated with the International Paediatric Pathology Association 1994;14(4):751-4.
1994: Hon Fong L Mark
Fluorescent in situ hybridization as an adjunct to conventional cytogenetics.
Annals of clinical and laboratory science 1994;24(2):153-63.
1993: Hon Fong L Mark; H E Wyandt; T Pan; R Mark; M Paramenter; W Campbell; Y Mark
A study of homologous chromosomes using a morphometric approach.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 1993;36(5):1003-6.
1993: L Braun; R Mikumo; Hon Fong L Mark; Stuart C Lauchlan
Analysis of the growth properties and physical state of the human papillomavirus type 16 genome in cell lines derived from primary cervical tumors.
The American journal of pathology 1993;143(3):832-44.
1993: Hon Fong L Mark; R Mark; T Pan; Y Mark
Centromere index derivation by a novel and convenient approach.
Annals of clinical and laboratory science 1993;23(4):267-74.
1993: Hon Fong L Mark; M Parmenter; W Campbell; R Mark; K Zolnierz; D Dunwoodie; E Hann; E Airall; K Santoro; Y Mark
A novel, convenient, and inexpensive approach for deriving ISCN (1985) relative lengths: validation by a morphometric study of 100 karyotyped metaphase cells.
Cytogenetics and cell genetics 1993;62(1):13-8.
1992: C L Jackson; D E Britt; Sharon L Graw; A Potts; K Santoro; AJ Buckler; David E Housman; Hon Fong L Mark
Construction and characterization of radiation hybrids for chromosome 9, and their use in mapping cosmid probes on the chromosome.
Somatic cell and molecular genetics 1992;18(3):285-301.
1992: K Hansen; J Bagtas; Hon Fong L Mark; A Homans; D B Singer
Undifferentiated small cell hepatoblastoma with a unique chromosomal translocation: a case report.
Pediatric pathology / affiliated with the International Paediatric Pathology Association 1992;12(3):457-62.