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Philipp Markart

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Malgorzata Wygrecka; Dariusz Zakrzewicz; Miroslava Didiasova; Grazyna Kwapiszewska; Klaus T Preissner; Brigitte Taborski; Philipp Markart
TGF-β1 induces tissue factor expression in human lung fibroblasts in a PI3K/JNK/Akt-dependent and AP-1-dependent manner.
Andreas Günther; Martina Korfei; Poornima Mahavadi; Clemens Ruppert; Daniel von der Beck; Philipp Markart
Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis.
Grazyna Kwapiszewska; Philipp Markart; Leigh Matthew Marsh; Andreas Meinhardt; Andrea Olschewski; Klaus Theo Preissner; Ralph Theo Schermuly; Werner Seeger; Martin Steinhoff; Christian Taube; Norbert Weissmann; Bhola Kumar Dahal; Hossein A Ghofrani; Baktybek Kojonazarov; Malgorzata Wygrecka
PAR-2 inhibition reverses experimental pulmonary hypertension.

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2012: Malgorzata Wygrecka; Dariusz Zakrzewicz; Miroslava Didiasova; Grazyna Kwapiszewska; Klaus T Preissner; Brigitte Taborski; Philipp Markart
TGF-β1 induces tissue factor expression in human lung fibroblasts in a PI3K/JNK/Akt-dependent and AP-1-dependent manner.
American journal of respiratory cell and molecular biology 2012;47(5):614-27.
2012: Andreas Günther; Martina Korfei; Poornima Mahavadi; Clemens Ruppert; Daniel von der Beck; Philipp Markart
Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis.
European respiratory review : an official journal of the European Respiratory Society 2012;21(124):152-60.
2012: Grazyna Kwapiszewska; Philipp Markart; Leigh Matthew Marsh; Andreas Meinhardt; Andrea Olschewski; Klaus Theo Preissner; Ralph Theo Schermuly; Werner Seeger; Martin Steinhoff; Christian Taube; Norbert Weissmann; Bhola Kumar Dahal; Hossein A Ghofrani; Baktybek Kojonazarov; Malgorzata Wygrecka
PAR-2 inhibition reverses experimental pulmonary hypertension.
Circulation research 2012;110(9):1179-91.
2012: J Grommes; Tilman M Hackeng; Michael Jacobs; Rory R Koenen; Wolfgang M Kuebler; Philipp Markart; Matthias Mörgelin; Klaus T Preissner; Philipp von Hundelshausen; Sarawuth Wantha; Christian Weber; Malgorzata Wygrecka; Jean-Eric Alard; Maik Drechsler; Oliver Soehnlein
Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury.
American journal of respiratory and critical care medicine 2012;185(6):628-36.
2012: Dariusz Zakrzewicz; Anna Zakrzewicz; Philipp Markart; Klaus T Preissner; Malgorzata Wygrecka
Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders.
International journal of molecular sciences 2012;13(10):12383-400.
2011: Malgorzata Wygrecka; Dariusz Zakrzewicz; Andreas Guenther; Ewa Jablonska; Klaus T Preissner; Werner Seeger; Jochen Wilhelm; Philipp Markart
Shedding of low-density lipoprotein receptor–related protein-1 in acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 2011;184(4):438-48.
2011: Malgorzata Wygrecka; Dariusz Zakrzewicz; Susanne von Gerlach; Klaus T Preissner; Andreas Guenther; Ingrid Henneke; Ewa Jablonska; Grazyna Kwapiszewska; Philipp Markart
Role of protease-activated receptor-2 in idiopathic pulmonary fibrosis.
American journal of respiratory and critical care medicine 2011;183(12):1703-14.
2011: Philipp Markart; Malgorzata Wygrecka; Andreas Guenther
Update in diffuse parenchymal lung disease 2010.
American journal of respiratory and critical care medicine 2011;183(10):1316-21.
2011: Martina Korfei; Günter Lochnit; Benjamin Loeh; Poornima Mahavadi; Philipp Markart; Klaus T Preissner; Clemens Ruppert; Liliana Schaefer; Sigrid Schmitt; Werner Seeger; Malgorzata Wygrecka; Philippe Bonniaud; Ludger Fink; Ingrid Henneke; Walter Klepetko; Andreas Guenther
Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs.
Journal of proteome research 2011;10(5):2185-205.
2010: Poornima Mahavadi; Martina Korfei; Ingrid Henneke; Gerhard Liebisch; Gerd Schmitz; Bernadette R Gochuico; Philipp Markart; Saverio Bellusci; Werner Seeger; Clemens Ruppert; Andreas Guenther
Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumonia.
American journal of respiratory and critical care medicine 2010;182(2):207-19.
2010: Clemens Ruppert; Tim Kuchenbuch; Marc Boensch; Sebastian Schmidt; Uwe Mathes; Vera Hillebrand; Ingrid Henneke; Philipp Markart; Irwin Reiss; Ralph T Schermuly; Werner Seeger; Andreas Günther
Dry powder aerosolization of a recombinant surfactant protein-C-based surfactant for inhalative treatment of the acutely inflamed lung.
Critical care medicine 2010;38(7):1584-91.
2010: Philipp Markart; Robert Nass; Clemens Ruppert; Lukas Hundack; Malgorzata Wygrecka; Martina Korfei; Rolf H Boedeker; Gerd Staehler; Hartmut Kroll; Gerhard Scheuch; Werner Seeger; Andreas Guenther
Safety and tolerability of inhaled heparin in idiopathic pulmonary fibrosis.
Journal of aerosol medicine and pulmonary drug delivery 2010;23(3):161-72.
2010: Ewa Jablonska; Philipp Markart; Dariusz Zakrzewicz; Klaus T Preissner; Malgorzata Wygrecka
Transforming growth factor-β1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts.
The Journal of biological chemistry 2010;285(15):11638-51.
2010: Ingrid Henneke; Susanne Greschus; Rajkumar Savai; Martina Korfei; Philipp Markart; Poornima Mahavadi; Ralph Theo Schermuly; Malgorzata Wygrecka; Jörg Stürzebecher; Werner Seeger; Andreas Günther; Clemens Ruppert
Inhibition of urokinase activity reduces primary tumor growth and metastasis formation in a murine lung carcinoma model.
American journal of respiratory and critical care medicine 2010;181(6):611-9.
2010: Ming Hua Bi; Juliane Ott; Tobias Fischer; Matthias Hecker; Hartmut Dietrich; Martina Barbara Schaefer; Philipp Markart; Bao En Wang; Werner Seeger; Konstantin Mayer
Induction of lymphocyte apoptosis in a murine model of acute lung injury--modulation by lipid emulsions.
Shock (Augusta, Ga.) 2010;33(2):179-88.
2009: Philipp Markart; Hossein A Ghofrani; Friedrich Grimminger; A Günther
[Pulmonary hypertension in COPD and interstitial lung diseases].
Deutsche medizinische Wochenschrift (1946) 2009;134 Suppl 5():S164-6.
2009: Malgorzata Wygrecka; Leigh M Marsh; Rory E Morty; Ingrid Henneke; Andreas Guenther; Jürgen Lohmeyer; Philipp Markart; Klaus T Preissner
Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung.
Blood 2009;113(22):5588-98.
2009: Philipp Markart; Thomas Luboeinski; Martina Korfei; Reinhold Schmidt; Malgorzata Wygrecka; Poornima Mahavadi; Konstantin Mayer; Jochen Wilhelm; Werner Seeger; Andreas Guenther; Clemens Ruppert
Alveolar oxidative stress is associated with elevated levels of nonenzymatic low-molecular-weight antioxidants in patients with different forms of chronic fibrosing interstitial lung diseases.
Antioxidants & redox signaling 2009;11(2):227-40.
2008: Clemens Ruppert; Poornima Mahavadi; Malgorzata Wygrecka; Timothy E Weaver; Viktor Magdolen; Steven Idell; Klaus T Preissner; Werner Seeger; Andreas Günther; Philipp Markart
Recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinase.
Thrombosis and haemostasis 2008;100(6):1185-92.
2008: Martina Korfei; Clemens Ruppert; Poornima Mahavadi; Ingrid Henneke; Philipp Markart; Miriam Koch; Gyoergy Lang; Ludger Fink; Rainer-Maria Bohle; Werner Seeger; Timothy E Weaver; Andreas Guenther
Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis.
American journal of respiratory and critical care medicine 2008;178(8):838-46.
2008: Malgorzata Wygrecka; Ewa Jablonska; Andreas Guenther; Klaus T Preissner; Philipp Markart
Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases.
Thrombosis and haemostasis 2008;99(3):494-501.
2008: Clemens Ruppert; Philipp Markart; Malgorzata Wygrecka; Klaus T Preissner; Andreas Günther
Role of coagulation and fibrinolysis in lung and renal fibrosis.
Hämostaseologie 2008;28(1-2):30-2, 34-6.
2008: Heinz-W Harbach; Kerstin Antrecht; Rolf-Hasso Boedeker; Gunter Hempelmann; Philipp Markart; Reginald Matejec; Joerg Muehling; Ingeborg Welters; Marek Zygmunt
Response to delivery stress is not mediated by beta-endorphin (1-31).
European journal of obstetrics, gynecology, and reproductive biology 2008;136(1):39-45.
2007: Malgorzata Wygrecka; Philipp Markart; Ludger Fink; Andreas Guenther; Klaus T Preissner
Raised protein levels and altered cellular expression of factor VII activating protease (FSAP) in the lungs of patients with acute respiratory distress syndrome (ARDS).
Thorax 2007;62(10):880-8.
2007: Malgorzata Wygrecka; Rory Morty; Philipp Markart; Sandip M Kanse; Peter A Andreasen; Troels Wind; Andreas Guenther; Klaus T Preissner
Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome.
The Journal of biological chemistry 2007;282(30):21671-82.
2007: Philipp Markart; Clemens Ruppert; Malgorzata Wygrecka; Thorsten Colaris; Bhola Dahal; Dieter Walmrath; Heinz-W Harbach; Jochen Wilhelm; Werner Seeger; Reinhold Schmidt; Andreas Guenther
Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipids.
Thorax 2007;62(7):588-94.
2007: Malgorzata Wygrecka; Philipp Markart; Clemens Ruppert; K Petri; Klaus T Preissner; Werner Seeger; Andreas Guenther
Cellular origin of pro-coagulant and (anti)-fibrinolytic factors in bleomycin-injured lungs.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(6):1105-14.
2007: Christian Kannemeier; Aya Shibamiya; Fumie Nakazawa; Heidi Trusheim; Clemens Ruppert; Philipp Markart; Yutong Song; Eleni Tzima; Elisabeth Kennerknecht; Michael Niepmann; Marie-Luise von Bruehl; Daniel G Sedding; Steffen Massberg; Andreas Günther; Bernd Engelmann; Klaus T Preissner
Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6388-93.
2007: Andreas Günther; Beate Enke; Philipp Markart; P Hammerl; Harald Morr; Jürgen Behr; Gerd Stähler; Werner Seeger; Friedrich Grimminger; I Leconte; S Roux; Hossein A Ghofrani
Safety and tolerability of bosentan in idiopathic pulmonary fibrosis: an open label study.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(4):713-9.
2007: Heinz-W Harbach; B Moll; Rolf-Hasso Boedeker; U Vigelius-Rauch; H Otto; J Muehling; Gunter Hempelmann; Philipp Markart
Minimal immunoreactive plasma beta-endorphin and decrease of cortisol at standard analgesia or different acupuncture techniques.
European journal of anaesthesiology 2007;24(4):370-6.
2007: Reinhold Schmidt; Philipp Markart; Clemens Ruppert; Malgorzata Wygrecka; Tim Kuchenbuch; Dieter Walmrath; Werner Seeger; Andreas Guenther
Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration.
Respiratory research 2007;8():55.
2007: Philipp Markart; Clemens Ruppert; Malgorzata Wygrecka; Reinhold Schmidt; Martina Korfei; Heinz-W Harbach; I Theruvath; Ulrich Pison; Werner Seeger; Andreas Guenther; H Witt
Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(1):134-7.
2006: Clemens Ruppert; Ariane Bagheri; Philipp Markart; Reinhold Schmidt; Werner Seeger; Andreas Günther
Liver carboxylesterase cleaves surfactant protein (SP-) B and promotes surfactant subtype conversion.
Biochemical and biophysical research communications 2006;348(4):1449-54.
2006: Reinhold Schmidt; Philipp Markart; Clemens Ruppert; Bettina Temmesfeld; Robert Nass; Jürgen Lohmeyer; Werner Seeger; Andreas Günther
Pulmonary surfactant in patients with Pneumocystis pneumonia and acquired immunodeficiency syndrome.
Critical care medicine 2006;34(9):2370-6.
2006: Philipp Markart; Werner Seeger; A Günther
[Differential therapy of pulmonary fibrosis].
Der Internist 2006;47 Suppl 1():S26-32.
2006: Andreas Günther; Philipp Markart; Oliver Eickelberg; Werner Seeger
[Pulmonary fibrosis--a therapeutic dilemma?].
Medizinische Klinik (Munich, Germany : 1983) 2006;101(4):308-12.
2005: Philipp Markart; Reinhold Schmidt; Clemens Ruppert; Christina Höres; Rolf-Edgar Silber; Jochen Börgermann; Andreas Günther; Ivar Friedrich
Ischemic and endotoxin pre-conditioning reduce lung reperfusion injury-induced surfactant alterations.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005;24(10):1680-9.
2005: Philipp Markart; L Hundack; Ardeschir Ghofrani; Friedrich Grimminger; Werner Seeger; Andreas Günther
[Idiopathic interstitial pneumonias: pathomechanisms and therapeutic options].
Pneumologie (Stuttgart, Germany) 2005;59(8):554-61.
2004: Henry T Akinbi; Vivek Narendran; Amy Kun Pass; Philipp Markart; Steven Hoath
Host defense proteins in vernix caseosa and amniotic fluid.
American journal of obstetrics and gynecology 2004;191(6):2090-6.
2004: Reinhold Schmidt; T Luboeinski; Philipp Markart; Clemens Ruppert; C Daum; Friedrich Grimminger; Werner Seeger; Andreas Günther
Alveolar antioxidant status in patients with acute respiratory distress syndrome.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;24(6):994-9.
2004: Malgorzata Wygrecka; Philipp Markart; Clemens Ruppert; Tim Kuchenbuch; Ludger Fink; Rainer M Bohle; Friedrich Grimminger; Werner Seeger; Andreas Günther
Compartment- and cell-specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application.
Thrombosis and haemostasis 2004;92(3):529-40.
2004: Philipp Markart; Nicole Faust; Thomas Graf; Cheng-Lun Na; Timothy E Weaver; Henry T Akinbi
Comparison of the microbicidal and muramidase activities of mouse lysozyme M and P.
The Biochemical journal 2004;380(Pt 2):385-92.
2004: Reinhold Schmidt; Clemens Ruppert; Philipp Markart; Norbert Lübke; Leander Ermert; Norbert Weissmann; Andreas Breithecker; Monika Ermert; Werner Seeger; Andreas Günther
Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis.
Toxicology and applied pharmacology 2004;195(2):218-31.
2004: Philipp Markart; Thomas R Korfhagen; Timothy E Weaver; Henry T Akinbi
Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infection.
American journal of respiratory and critical care medicine 2004;169(4):454-8.
2004: Andreas Günther; Markus Balser; Reinhold Schmidt; Philipp Markart; Alexander Olk; Jochen Börgermann; Fred H Splittgerber; Werner Seeger; Ivar Friedrich
Surfactant abnormalities after single lung transplantation in dogs: impact of bronchoscopic surfactant administration.
The Journal of thoracic and cardiovascular surgery 2004;127(2):344-54.
2003: Andreas Günther; Norbert Lübke; Monika Ermert; Ralph Theo Schermuly; Norbert Weissmann; Andreas Breithecker; Philipp Markart; Clemens Ruppert; Karin Quanz; Leander Ermert; Friedrich Grimminger; Werner Seeger
Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits.
American journal of respiratory and critical care medicine 2003;168(11):1358-65.
2003: Clemens Ruppert; Carolin Pucker; Philipp Markart; Kerstin Seibold; Ariane Bagheri; Friedrich Grimminger; Werner Seeger; Andreas Günther
Impact of surface tension on the conversion rate of large to small surfactant aggregates.
Biophysical chemistry 2003;104(1):229-38.
2003: Clemens Ruppert; Philipp Markart; Reinhold Schmidt; Friedrich Grimminger; Werner Seeger; Claus-Michael Lehr; Andreas Günther
Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin.
Thrombosis and haemostasis 2003;89(1):53-64.
2003: Clemens Ruppert; Carolin Pucker; Philipp Markart; Reinhold Schmidt; Friedrich Grimminger; Werner Seeger; Jörg Stürzebecher; Andreas Günther
Selective inhibition of large-to-small surfactant aggregate conversion by serine protease inhibitors of the bis-benzamidine type.
American journal of respiratory cell and molecular biology 2003;28(1):95-102.
2003: Philipp Markart; Clemens Ruppert; Friedrich Grimminger; Werner Seeger; Andreas Günther
Fibrinolysis-inhibitory capacity of clot-embedded surfactant is enhanced by SP-B and SP-C.
American journal of physiology. Lung cellular and molecular physiology 2003;284(1):L69-76.
2002: Reinhold Schmidt; U Meier; Philipp Markart; Friedrich Grimminger; Hans-Georg Velcovsky; Harald Morr; Werner Seeger; Andreas Günther
Altered fatty acid composition of lung surfactant phospholipids in interstitial lung disease.
American journal of physiology. Lung cellular and molecular physiology 2002;283(5):L1079-85.
2001: Andreas Günther; Clemens Ruppert; Reinhold Schmidt; Philipp Markart; Friedrich Grimminger; Dieter Walmrath; Werner Seeger
Surfactant alteration and replacement in acute respiratory distress syndrome.
Respiratory research 2001;2(6):353-64.
2000: Andreas Günther; P Mosavi; Sabine Heinemann; Clemens Ruppert; Heidrun Muth; Philipp Markart; Friedrich Grimminger; Dieter Walmrath; Bettina Temmesfeld-Wollbrück; Werner Seeger
Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Comparison with the acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 2000;161(2 Pt 1):454-62.
1999: Andreas Günther; Philipp Markart; M Kalinowski; Clemens Ruppert; Friedrich Grimminger; Werner Seeger
Cleavage of surfactant-incorporating fibrin by different fibrinolytic agents. Kinetics of lysis and rescue of surface activity.
American journal of respiratory cell and molecular biology 1999;21(6):738-45.