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Thomas Markees

Research Profile

Chemicals & Drugs

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CD8-Positive T-Lymphocytes

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Thomas B Thornley; Nancy E Phillips; Britte C Beaudette-Zlatanova; Thomas G Markees; Kapil Bahl; Michael A Brehm; Leonard D Shultz; Evelyn A Kurt-Jones; John P Mordes; Raymond M Welsh; Aldo A Rossini; Dale L Greiner
Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
M Yamazaki; Todd Pearson; Michael A Brehm; D M Miller; Julie Mangada; Thomas G Markees; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
Michael A Brehm; Julie Mangada; Thomas G Markees; Todd Pearson; Keith A Daniels; Thomas B Thornley; Raymond M Welsh; Aldo A Rossini; Dale L Greiner
Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.

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2007: Thomas B Thornley; Nancy E Phillips; Britte C Beaudette-Zlatanova; Thomas G Markees; Kapil Bahl; Michael A Brehm; Leonard D Shultz; Evelyn A Kurt-Jones; John P Mordes; Raymond M Welsh; Aldo A Rossini; Dale L Greiner
Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6620-9.
2007: M Yamazaki; Todd Pearson; Michael A Brehm; D M Miller; Julie Mangada; Thomas G Markees; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(7):1710-21.
2007: Michael A Brehm; Julie Mangada; Thomas G Markees; Todd Pearson; Keith A Daniels; Thomas B Thornley; Raymond M Welsh; Aldo A Rossini; Dale L Greiner
Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.
Blood 2007;109(2):819-26.
2006: Thomas B Thornley; Michael A Brehm; Thomas G Markees; Leonard D Shultz; John P Mordes; Raymond M Welsh; Aldo A Rossini; Dale L Greiner
TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1561-70.
2005: Ethel J Gordon; Linda S Wicker; Laurence B Peterson; David V Serreze; Thomas G Markees; Leonard D Shultz; Aldo A Rossini; Dale L Greiner; John P Mordes
Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
Diabetes 2005;54(1):107-15.
2004: Thomas G Markees; Todd Pearson; Amy Cuthbert; Andrea L Pearson; Leonard D Shultz; Jean Leif; Nancy E Phillips; John P Mordes; Dale L Greiner; Aldo A Rossini
Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.
Transplantation 2004;78(11):1601-8.
2004: Scott J Banuelos; Thomas G Markees; Nancy E Phillips; Michael C Appel; Amy Cuthbert; Jean Leif; John P Mordes; Leonard D Shultz; Aldo A Rossini; Dale L Greiner
Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.
Transplantation 2004;78(5):660-7.
2004: Todd Pearson; Peter Weiser; Thomas G Markees; David V Serreze; Linda S Wicker; Laurence B Peterson; Anne-Marie Cumisky; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Diabetes 2004;53(8):1972-8.
2003: Todd Pearson; Thomas G Markees; David V Serreze; Melissa A Pierce; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
Annals of the New York Academy of Sciences 2003;1005():148-56.
2003: Todd Pearson; Thomas G Markees; David V Serreze; Melissa A Pierce; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
Reviews in endocrine & metabolic disorders 2003;4(3):255-61.
2003: Todd Pearson; Thomas G Markees; David V Serreze; Melissa A Pierce; Michele P Marron; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):185-95.
2003: Michael A Brehm; Thomas G Markees; Keith A Daniels; Dale L Greiner; Aldo A Rossini; Raymond M Welsh
Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4077-86.
2003: Nancy E Phillips; Thomas G Markees; John P Mordes; Dale L Greiner; Aldo A Rossini
Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3015-23.
2003: Todd Pearson; Thomas G Markees; Linda S Wicker; David V Serreze; Laurence B Peterson; John P Mordes; Aldo A Rossini; Dale L Greiner
NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.
Diabetes 2003;52(2):321-6.
2002: Daron Forman; Raymond M Welsh; Thomas G Markees; Bruce A Woda; John P Mordes; Aldo A Rossini; Dale L Greiner
Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6047-56.
2001: Neal Iwakoshi; Thomas G Markees; Nicole A Turgeon; Thomas B Thornley; Amy Cuthbert; Jean Leif; Nancy E Phillips; John P Mordes; Dale L Greiner; Aldo A Rossini
Skin allograft maintenance in a new synchimeric model system of tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6623-30.
2001: Thomas G Markees
Islet isolation: simple modifications can still yield big improvements.
Transplantation 2001;72(4):562-3.
2000: Edward Seung; Neal Iwakoshi; Bruce A Woda; Thomas G Markees; John P Mordes; Aldo A Rossini; Dale L Greiner
Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice.
Blood 2000;95(6):2175-82.
2000: Raymond M Welsh; Thomas G Markees; Bruce A Woda; Keith A Daniels; Michael A Brehm; John P Mordes; Dale L Greiner; Aldo A Rossini
Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody.
Journal of virology 2000;74(5):2210-8.
2000: Neal Iwakoshi; John P Mordes; Thomas G Markees; Nancy E Phillips; Aldo A Rossini; Dale L Greiner
Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):512-21.
1999: Thomas G Markees; David V Serreze; Nancy E Phillips; C H Sorli; Ethel J Gordon; Leonard D Shultz; RJ Noelle; Bruce A Woda; Dale L Greiner; John P Mordes; Aldo A Rossini
NOD mice have a generalized defect in their response to transplantation tolerance induction.
Diabetes 1999;48(5):967-74.
1999: Xin Xiao Zheng; Thomas G Markees; Wayne W Hancock; Yongsheng Li; D L Greiner; Xian Chang Li; John P Mordes; Mohamed H Sayegh; Aldo A Rossini; Terry B Strom
CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4983-90.
1999: Thomas G Markees; Nancy E Phillips; Ethel J Gordon; RJ Noelle; C Maliszewski; John P Mordes; Dale L Greiner; Aldo A Rossini
Prolonged skin allograft survival in mice treated with Flt3-ligand-induced dendritic cells and anti-CD154 monoclonal antibody.
Transplantation proceedings 1999;31(1-2):884-5.
1999: Aldo A Rossini; John P Mordes; Thomas G Markees; Nancy E Phillips; Ethel J Gordon; Dale L Greiner
Induction of islet transplantation tolerance using donor specific transfusion and anti-CD154 monoclonal antibody.
Transplantation proceedings 1999;31(1-2):629-32.
1998: Thomas G Markees; N Phillips; E Gordon; RJ Noelle; John P Mordes; Dale L Greiner; Aldo A Rossini
Improved skin allograft tolerance induced by treatment with donor splenocytes and an extended course of anti-CD154 monoclonal antibody.
Transplantation proceedings 1998;30(5):2444-6.
1998: Ethel J Gordon; Thomas G Markees; Nancy E Phillips; RJ Noelle; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody.
Diabetes 1998;47(8):1199-206.
1998: Thomas G Markees; Nancy E Phillips; Ethel J Gordon; RJ Noelle; Leonard D Shultz; John P Mordes; Dale L Greiner; Aldo A Rossini
Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.
The Journal of clinical investigation 1998;101(11):2446-55.
1997: Thomas G Markees; Nancy E Phillips; RJ Noelle; Leonard D Shultz; John P Mordes; Dale L Greiner; Aldo A Rossini
Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand.
Transplantation 1997;64(2):329-35.
1996: Thomas G Markees; M C Appel; RJ Noelle; John P Mordes; Dale L Greiner; Aldo A Rossini
Tolerance to islet xenografts induced by dual manipulation of antigen presentation and co-stimulation.
Transplantation proceedings 1996;28(2):814-5.