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Alexander Markham

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Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

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Danielle Ingham; Alexander F Markham; Nazneen Rahman; Eamonn G Sheridan; Ian Berry; David T Bonthron; Claire A Bristow; Christine P Diggle; Bruce E Hayward; Ian M Carr
Simple detection of germline microsatellite instability for diagnosis of constitutional mismatch repair cancer syndrome.
Ian M Carr; Alexander F Markham; Hanan E Shamseldin; James O'Sullivan; Mohammed Aldahmesh; Sanjeev Bhaskar; Graeme Black; David T Bonthron; Fowzan S Alkuraya
Autozygosity mapping with exome sequence data.
Philip A Chambers; Victoria Crowe; Helen Dickinson; Alexander F Markham; Joanne E Morgan; Clive Mulatero; Philip Quirke; Paul Roberts; Matthew Seymour; Lucy F Stead; Kate M Sutton; Paul M Waring; Christopher M Watson; Ian M Carr; Graham R Taylor
Mutation detection by clonal sequencing of PCR amplicons and grouped read typing is applicable to clinical diagnostics.

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2013: Danielle Ingham; Alexander F Markham; Nazneen Rahman; Eamonn G Sheridan; Ian Berry; David T Bonthron; Claire A Bristow; Christine P Diggle; Bruce E Hayward; Ian M Carr
Simple detection of germline microsatellite instability for diagnosis of constitutional mismatch repair cancer syndrome.
Human mutation 2013;34(6):847-52.
2013: Ian M Carr; Alexander F Markham; Hanan E Shamseldin; James O'Sullivan; Mohammed Aldahmesh; Sanjeev Bhaskar; Graeme Black; David T Bonthron; Fowzan S Alkuraya
Autozygosity mapping with exome sequence data.
Human mutation 2013;34(1):50-6.
2013: Philip A Chambers; Victoria Crowe; Helen Dickinson; Alexander F Markham; Joanne E Morgan; Clive Mulatero; Philip Quirke; Paul Roberts; Matthew Seymour; Lucy F Stead; Kate M Sutton; Paul M Waring; Christopher M Watson; Ian M Carr; Graham R Taylor
Mutation detection by clonal sequencing of PCR amplicons and grouped read typing is applicable to clinical diagnostics.
Human mutation 2013;34(1):248-54.
2012: Sally A Peyman; Radwa H Abou-Saleh; P Louise Coletta; Kevin Critchley; J Anthony Evans; Steven Freear; Nicola Ingram; Benjamin R G Johnson; Alexander F Markham; James R McLaughlan; Stephen D Evans
Expanding 3D geometry for enhanced on-chip microbubble production and single step formation of liposome modified microbubbles.
Lab on a chip 2012;12(21):4544-52.
2012: Mostafa A Abdelrahman; J Anthony Evans; Mark A Hull; Pamela F Jones; Alexander F Markham; Gemma Marston; P Louise Coletta
High-frequency ultrasound for in vivo measurement of colon wall thickness in mice.
Ultrasound in medicine & biology 2012;38(3):432-42.
2012: Ian M Carr; Christine P Diggle; Angus Dobbie; Chris Inglehearn; Kamron Khan; Alexander F Markham; Martin McKibbin; Sergio D J Pena; Rashida Anwar; David T Bonthron; Manir Ali
Rapid visualisation of microarray copy number data for the detection of structural variations linked to a disease phenotype.
PloS one 2012;7(8):e43466.
2011: Clare V Logan; Barbara Lucke; Adnan Y Manzur; Alexander F Markham; Grace Markham; Joanne E Morgan; Francesco Muntoni; David A Parry; Caroline Pottinger; Markus Schuelke; Mariacristina Scoto; Eamonn Sheridan; Michael Shires; Katarzyna Szymanska; Graham R Taylor; Anne van Riesen; Zakia A Abdelhamed; David T Bonthron; Ian Carr; Christine P Diggle; Ian Ellis; Tim Helliwell; Christoph Hübner; Colin A Johnson
Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD).
Nature genetics 2011;43(12):1189-92.
2011: Ian M Carr; Nick Camm; Graham R Taylor; Ruth Charlton; Sian Ellard; Eamonn G Sheridan; Alexander F Markham; David T Bonthron
GeneScreen: a program for high-throughput mutation detection in DNA sequence electropherograms.
Journal of medical genetics 2011;48(2):123-30.
2010: C P Diggle; M Shires; C McRae; D Crellin; J Fisher; Ian Carr; Alexander F Markham; Bruce E Hayward; Aruna Asipu; David T Bonthron
Both isoforms of ketohexokinase are dispensable for normal growth and development.
Physiological genomics 2010;42A(4):235-43.
2010: Christine P Diggle; Ian M Carr; Emanuel Zitt; Katie Wusik; Robert J Hopkin; Carlos E Prada; Olga Calabrese; Olaf Rittinger; Marilynn G Punaro; Alexander F Markham; David T Bonthron
Common and recurrent HPGD mutations in Caucasian individuals with primary hypertrophic osteoarthropathy.
Rheumatology (Oxford, England) 2010;49(6):1056-62.
2010: James A Poulter; Manir Ali; David F Gilmour; Aine Rice; Hiroyuki Kondo; Kenshi Hayashi; David A Mackey; Lisa S Kearns; Jonathan B Ruddle; Jamie E Craig; Eric A Pierce; Louise M Downey; Moin D Mohamed; Alexander F Markham; Chris F Inglehearn; Carmel Toomes
Mutations in TSPAN12 cause autosomal-dominant familial exudative vitreoretinopathy.
American journal of human genetics 2010;86(2):248-53.
2009: Ian M Carr; Katarzyna Szymanska; Eamonn Sheridan; Alexander F Markham; David T Bonthron; Colin A Johnson
Shadow autozygosity mapping by linkage exclusion (SAMPLE): a simple strategy to identify the genetic basis of lethal autosomal recessive disorders.
Human mutation 2009;30(12):1642-9.
2009: Ian Carr; Eamonn Sheridan; Bruce E Hayward; Alexander F Markham; David T Bonthron
IBDfinder and SNPsetter: tools for pedigree-independent identification of autozygous regions in individuals with recessive inherited disease.
Human mutation 2009;30(6):960-7.
2009: S A Boxall; Graham P Cook; D Pearce; D Bonnet; Yasser El-Sherbiny; M P Blundell; S J Howe; J P Leek; Alexander F Markham; Erika A de Wynter
Haematopoietic repopulating activity in human cord blood CD133+ quiescent cells.
Bone marrow transplantation 2009;43(8):627-35.
2008: Sandeep Uppal; Christine P Diggle; Ian Carr; Colin W G Fishwick; Mushtaq Ahmed; Gamal H Ibrahim; Philip S Helliwell; Anna Latos-Bieleńska; Simon E V Phillips; Alexander F Markham; Christopher P Bennett; David T Bonthron
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy.
Nature genetics 2008;40(6):789-93.
2008: Chi H Trinh; Walid Sh Elsayed; Peyman Eshghi; Ebrahim Miri-Moghaddam; Azita Zadeh-Vakili; Alexander F Markham; Rashida Anwar
Molecular analysis of sixteen unrelated factor XIIIA deficient families from south-east of Iran.
British journal of haematology 2008;140(5):581-4.
2007: Ian Carr; Elizabeth M A Valleley; Sarah F Cordery; Alexander F Markham; David T Bonthron
Sequence analysis and editing for bisulphite genomic sequencing projects.
Nucleic acids research 2007;35(10):e79.
2006: Ian Carr; Kimberley J Flintoff; Graham Taylor; Alexander F Markham; David T Bonthron
Interactive visual analysis of SNP data for rapid autozygosity mapping in consanguineous families.
Human mutation 2006;27(10):1041-6.
2006: Josephine L Meade; Erika A de Wynter; Peter Brett; Saghira Malik Sharif; C Geoffrey Woods; Alexander F Markham; Graham P Cook
A family with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity.
Blood 2006;107(9):3665-8.
2006: Mark A Hull; O O Faluyi; C W S Ko; Sarah Holwell; Daniel Scott; Richard J Cuthbert; Richard Poulsom; R Goodlad; Constanze Bonifer; Alexander F Markham; P Louise Coletta
Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis.
Carcinogenesis 2006;27(3):382-91.
2006: Ann W Morgan; Jennifer H Barrett; Bridget Griffiths; Deepak Subramanian; James Robinson; Viki H Keyte; Manir Ali; Elizabeth A Jones; Robert W Old; Frederique Ponchel; Arthur W Boylston; R Deva Situnayake; Alexander F Markham; Paul Emery; John D Isaacs
Analysis of Fcgamma receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B.
Arthritis research & therapy 2006;8(1):R5.
2005: Jonathan M Wilson; P Louise Coletta; Richard J Cuthbert; Nigel Scott; Kenneth A MacLennan; Gillian Hawcroft; Lin Leng; Jodi B Lubetsky; Kai K Jin; Elias Lolis; Francisco Medina; José A Brieva; Richard Poulsom; Alexander F Markham; Richard Bucala; Mark A Hull
Macrophage migration inhibitory factor promotes intestinal tumorigenesis.
Gastroenterology 2005;129(5):1485-503.
2005: Gina M Doody; Jack P Leek; A K Bali; Armin Ensser; Alexander F Markham; Erika A de Wynter
Marker gene transfer into human haemopoietic cells using a herpesvirus saimiri-based vector.
Gene therapy 2005;12(4):373-9.
2005: Frederique Ponchel; Robert J Verburg; Sarah J Bingham; Andrew K Brown; John Moore; Andrew Protheroe; Kath Short; Catherine A Lawson; Ann W Morgan; Mark Quinn; Maya H Buch; Sarah L Field; Sarah L Maltby; Aurelie Masurel; Susan H Douglas; Liz Straszynski; Ursula Fearon; douglas veale; Poulam Patel; Dennis McGonagle; John Snowden; Alexander F Markham; David Ma; Jacob M van Laar; Helen A Papadaki; Paul Emery; John D Isaacs
Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia.
Arthritis research & therapy 2005;7(1):R80-92.
2004: Clare N Lynex; Ian Carr; Jack P Leek; Rajgopal Achuthan; Simon Mitchell; Eamonn R Maher; C Geoffrey Woods; David T Bonthon; Alexander F Markham
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
BMC neurology 2004;4(1):20.
2004: AH Mansur; Tim BISHOP; S T Holgate; Alexander F Markham; J F J Morrison
Linkage/association study of a locus modulating total serum IgE on chromosome 14q13-24 in families with asthma.
Thorax 2004;59(10):876-82.
2004: Elizabeth J Fox; Sally A Stubbs; Jimmy Kyaw Tun; Jack P Leek; Alexander F Markham; Stephanie C Wright
PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein.
The Biochemical journal 2004;378(Pt 3):817-25.
2004: Elena A Jones; Anne English; Karen Henshaw; Sally E Kinsey; Alexander F Markham; Paul Emery; Dennis McGonagle
Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis.
Arthritis and rheumatism 2004;50(3):817-27.
2004: P Louise Coletta; Albrecht M Müller; Elena A Jones; Bettina Mühl; Sarah Holwell; Deborah Clarke; Josephine L Meade; Graham P Cook; Gillian Hawcroft; Frederique Ponchel; Wai K Lam; Kenneth A MacLennan; Mark A Hull; Constanze Bonifer; Alexander F Markham
Lymphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis.
Blood 2004;103(3):1050-8.
2004: MK Karayi; Alexander F Markham
Molecular biology of prostate cancer.
Prostate cancer and prostatic diseases 2004;7(1):6-20.
2003: Nancy G S Tan; Helen C Ardley; Gina B Scott; Stephen A Rose; Alexander F Markham; Philip A Robinson
Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP.
FEBS letters 2003;554(3):501-4.
2003: Helen C Ardley; Gina B Scott; Stephen A Rose; Nancy G S Tan; Alexander F Markham; Philip A Robinson
Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin.
Molecular biology of the cell 2003;14(11):4541-56.
2003: Frederique Ponchel; Carmel Toomes; Kieran L Bransfield; Fong T Leong; Susan H Douglas; Sarah L Field; Sandra M Bell; Valérie Combaret; Alain Puisieux; Alan J Mighell; Philip A Robinson; Chris F Inglehearn; John D Isaacs; Alexander F Markham
Real-time PCR based on SYBR-Green I fluorescence: an alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions.
BMC biotechnology 2003;3():18.
2003: GEORGIOS SKLIRIS; Kailas Munot; Sandra M Bell; Pauline J Carder; Sally Lane; Kieran Horgan; Mark R J Lansdown; Alicia T Parkes; Andrew M Hanby; Alexander F Markham; Valerie Speirs
Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model.
The Journal of pathology 2003;201(2):213-20.
2003: David R FitzPatrick; Ian Carr; Lorna McLaren; Jack P Leek; Patrick J Wightman; Kathy Williamson; Philippe Gautier; Niolette I McGill; Caroline Hayward; Helen Firth; Alexander F Markham; Judy A Fantes; David T Bonthron
Identification of SATB2 as the cleft palate gene on 2q32-q33.
Human molecular genetics 2003;12(19):2491-501.
2003: M Ali; douglas veale; Richard Reece; Mark Quinn; Karen Henshaw; Edward Zanders; Alexander F Markham; Paul Emery; John D Isaacs
Overexpression of transcripts containing LINE-1 in the synovia of patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2003;62(7):663-6.
2003: Achuthan Rajgopal; Ian Carr; Jack P Leek; Donald Hodge; Sandra M Bell; Paul Roberts; Kieran Horgan; David T Bonthron; Peter J Selby; Alexander F Markham; Kenneth A MacLennan
Detection by fluorescence in situ hybridization of microdeletions at 1p36 in lymphomas, unidentified on cytogenetic analysis.
Cancer genetics and cytogenetics 2003;142(1):46-50.
2003: Ann W Morgan; V H Keyte; S J Babbage; James Robinson; Frederique Ponchel; Jennifer H Barrett; Bipinchandra Bhakta; Sarah J Bingham; Maya H Buch; Philip Conaghan; A K S Gough; M Green; Catherine A Lawson; Colin Pease; Alexander F Markham; W E R Ollier; Paul Emery; J Worthington; John D Isaacs
FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study.
Rheumatology (Oxford, England) 2003;42(4):528-33.
2002: Frederique Ponchel; Ann W Morgan; Sarah J Bingham; Mark Quinn; Maya H Buch; Robert J Verburg; Judy Henwood; Susan H Douglas; Aurelie Masurel; Philip Conaghan; Moji Gesinde; Julia Taylor; Alexander F Markham; Paul Emery; Jacob M van Laar; John D Isaacs
Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis.
Blood 2002;100(13):4550-6.
2002: Jimi Adu; Fong T Leong; Neil R Smith; Jack P Leek; Alexander F Markham; Philip A Robinson; Alan J Mighell
Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development.
Mechanisms of development 2002;119 Suppl 1():S43-7.
2002: Elena A Jones; Sally E Kinsey; Anne English; Richard A Jones; Liz Straszynski; David M Meredith; Alexander F Markham; Andrew Jack; Paul Emery; Dennis McGonagle
Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells.
Arthritis and rheumatism 2002;46(12):3349-60.
2002: Jimi Adu; Fong T Leong; Neil R Smith; Jack P Leek; Alexander F Markham; Philip A Robinson; Alan J Mighell
Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development.
Gene expression patterns : GEP 2002;2(1-2):39-43.
2002: Stanley C W Ko; Keith S Chapple; Gillian Hawcroft; P Louise Coletta; Alexander F Markham; Mark A Hull
Paracrine cyclooxygenase-2-mediated signalling by macrophages promotes tumorigenic progression of intestinal epithelial cells.
Oncogene 2002;21(47):7175-86.
2002: Jacquelyn Bond; Emma Roberts; Ganeshwaran H Mochida; Daniel J Hampshire; Sheila Scott; Jon M Askham; Kelly Springell; Meera Mahadevan; Yanick J Crow; Alexander F Markham; Christopher Walsh; C Geoffrey Woods
ASPM is a major determinant of cerebral cortical size.
Nature genetics 2002;32(2):316-20.
2002: Nicola J Marchbank; Jamie E Craig; Jack P Leek; Michael G Toohey; Amanda J Churchill; Alexander F Markham; David A Mackey; Carmel Toomes; Chris F Inglehearn
Deletion of the OPA1 gene in a dominant optic atrophy family: evidence that haploinsufficiency is the cause of disease.
Journal of medical genetics 2002;39(8):e47.
2002: Andrew P Jackson; Helen Eastwood; Sandra M Bell; Jimi Adu; Carmel Toomes; Ian Carr; Emma Roberts; Daniel J Hampshire; Yanick J Crow; Alan J Mighell; Gulshan Karbani; Hussain Jafri; Yasmin Rashid; Robert F Mueller; Alexander F Markham; C Geoffrey Woods
Identification of microcephalin, a protein implicated in determining the size of the human brain.
American journal of human genetics 2002;71(1):136-42.
2002: T Jeffrey Keen; Matthew M Hims; Arthur B McKie; Anthony T Moore; Rob M Doran; David A Mackey; David C Mansfield; Robert F Mueller; Shomi S Bhattacharya; Alan C Bird; Alexander F Markham; Chris F Inglehearn
Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa.
European journal of human genetics : EJHG 2002;10(4):245-9.
2002: Abeezar I Sarela; Caroline S Verbeke; J Ramsdale; C L Davies; Alexander F Markham; Pierre J Guillou
Expression of survivin, a novel inhibitor of apoptosis and cell cycle regulatory protein, in pancreatic adenocarcinoma.
British journal of cancer 2002;86(6):886-92.
2002: Rashida Anwar; Adrian Minford; Louise Gallivan; Chi H Trinh; Alexander F Markham
Delayed umbilical bleeding--a presenting feature for factor XIII deficiency: clinical features, genetics, and management.
Pediatrics 2002;109(2):E32.
2002: Gillian Hawcroft; Mark D'Amico; Chris Albanese; Alexander F Markham; Richard G Pestell; Mark A Hull
Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells.
Carcinogenesis 2002;23(1):107-14.
2002: Rajgopal Achuthan; Sandra M Bell; Ian Carr; Jack P Leek; Paul Roberts; Kieran Horgan; Alexander F Markham; Peter J Selby; Kenneth A MacLennan
BCL10 in malignant lymphomas--an evaluation using fluorescence in situ hybridization.
The Journal of pathology 2002;196(1):59-66.
2001: Peter G Smith; P Louise Coletta; Alexander F Markham; Adrian Whitehouse
In vivo episomal maintenance of a herpesvirus saimiri-based gene delivery vector.
Gene therapy 2001;8(23):1762-9.
2001: Rajgopal Achuthan; Sandra M Bell; Paul Roberts; Jack P Leek; Kieran Horgan; Alexander F Markham; Kenneth A MacLennan; Valerie Speirs
Genetic events during the transformation of a tamoxifen-sensitive human breast cancer cell line into a drug-resistant clone.
Cancer genetics and cytogenetics 2001;130(2):166-72.
2001: Daniel Scott; Mark A Hull; EJ Cartwright; Wai K Lam; A Tisbury; Richard Poulsom; Alexander F Markham; Constanze Bonifer; P Louise Coletta
Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse.
Gastroenterology 2001;121(4):889-99.
2001: Walid Zedan; Philip A Robinson; Alexander F Markham; Alec S High
Expression of the Sonic Hedgehog receptor "PATCHED" in basal cell carcinomas and odontogenic keratocysts.
The Journal of pathology 2001;194(4):473-7.
2001: Andrew R J Curtis; Constanze Fey; Christopher M Morris; L A Bindoff; Paul Geoffrey Ince; Patrick F Chinnery; Alan Coulthard; Margaret J Jackson; Andrew P Jackson; Duncan P McHale; D Hay; WA Barker; Alexander F Markham; David Bates; Ann Curtis; John Burn
Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease.
Nature genetics 2001;28(4):350-4.
2001: Arthur B McKie; John McHale; T Jeffrey Keen; Emma E Tarttelin; R Goliath; Janneke J C van Lith-Verhoeven; Jacquie Greenberg; Rajkumar Ramesar; Carel B Hoyng; Frans P M Cremers; David A Mackey; Shomi S Bhattacharya; Alan C Bird; Alexander F Markham; Chris F Inglehearn
Mutations in the pre-mRNA splicing factor gene PRPC8 in autosomal dominant retinitis pigmentosa (RP13).
Human molecular genetics 2001;10(15):1555-62.
2001: Carmel Toomes; Nicola J Marchbank; David A Mackey; Jamie E Craig; R A Newbury-Ecob; C P Bennett; C J Vize; S P Desai; Graeme C M Black; N Patel; M Teimory; Alexander F Markham; Chris F Inglehearn; Amanda J Churchill
Spectrum, frequency and penetrance of OPA1 mutations in dominant optic atrophy.
Human molecular genetics 2001;10(13):1369-78.
2001: Helen C Ardley; Nancy G S Tan; Stephen A Rose; Alexander F Markham; Philip A Robinson
Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.
The Journal of biological chemistry 2001;276(22):19640-7.
2001: Abeezar I Sarela; Nigel Scott; J Ramsdale; Alexander F Markham; Pierre J Guillou
Immunohistochemical detection of the anti-apoptosis protein, survivin, predicts survival after curative resection of stage II colorectal carcinomas.
Annals of surgical oncology 2001;8(4):305-10.
2001: Elizabeth M A Valleley; EJ Cartwright; N J Croft; Alexander F Markham; P Louise Coletta
Characterisation and expression of Sox9 in the Leopard gecko, Eublepharis macularius.
The Journal of experimental zoology 2001;291(1):85-91.
2001: Manir Ali; Frederique Ponchel; K E Wilson; M J Francis; X Wu; Adrienne Verhoef; Arthur W Boylston; douglas veale; Paul Emery; Alexander F Markham; Jonathan R Lamb; John D Isaacs
Rheumatoid arthritis synovial T cells regulate transcription of several genes associated with antigen-induced anergy.
The Journal of clinical investigation 2001;107(4):519-28.
2001: E G Ward; Konstantina Grosios; Alexander F Markham; Pam Jones
Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2.
Cytogenetics and cell genetics 2001;94(3-4):147-54.
2001: Tim Hutchin; NJ Lench; S Arbuzova; Alexander F Markham; Robert F Mueller
Maternally inherited hearing impairment in a family with the mitochondrial DNA A7445G mutation.
European journal of human genetics : EJHG 2001;9(1):56-8.
2000: L J Pulleyn; Andrew P Jackson; Emma Roberts; A Carridice; C Muxworthy; MJ Houseman; Lihadh Al-Gazali; NJ Lench; Alexander F Markham; Robert F Mueller
A new locus for autosomal recessive non-syndromal sensorineural hearing impairment (DFNB27) on chromosome 2q23-q31.
European journal of human genetics : EJHG 2000;8(12):991-3.
2000: S Wedgwood; Wai K Lam; K M Pinchin; Alexander F Markham; EJ Cartwright; P Louise Coletta
Characterization of a brain-selective transcript of the Adenomatous polyposis coli tumor suppressor gene.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(12):1150-3.
2000: Rajgopal Achuthan; Sandra M Bell; Jack P Leek; Paul Roberts; Kieran Horgan; Alexander F Markham; Peter J Selby; Kenneth A MacLennan
Novel translocation of the BCL10 gene in a case of mucosa associated lymphoid tissue lymphoma.
Genes, chromosomes & cancer 2000;29(4):347-9.
2000: Kersten T Hall; Mathew S Giles; Delyth J Goodwin; Michael A Calderwood; Alexander F Markham; Adrian Whitehouse
Characterization of the herpesvirus saimiri ORF73 gene product.
The Journal of general virology 2000;81(Pt 11):2653-8.
2000: MK Karayi; David E Neal; Alexander F Markham
Current status of linkage studies in hereditary prostate cancer.
BJU international 2000;86(6):659-69.
2000: Rashida Anwar; Louise Gallivan; KJ Miloszewski; Alexander F Markham
Factor XIII deficiency causing mutation, Ser295Arg, in exon 7 of the factor XIIIA gene.
Thrombosis and haemostasis 2000;84(4):591-4.
2000: Ann W Morgan; Bridget Griffiths; Frederique Ponchel; B M Montague; Manir Ali; P P Gardner; Hock C Gooi; R Deva Situnayake; Alexander F Markham; Paul Emery; John D Isaacs
Fcgamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups.
Arthritis and rheumatism 2000;43(10):2328-34.
2000: AH Mansur; G A Williams; D Timothy Bishop; Alexander F Markham; S Lewis; J Britton; J F J Morrison
Evidence for a role of HLA DRB1 alleles in the control of IgE levels, strengthened by interacting TCR A/D marker alleles.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(10):1371-8.
2000: Tim Hutchin; MJ Parker; ID Young; Adrian Davis; L J Pulleyn; J Deeble; NJ Lench; Alexander F Markham; Robert F Mueller
A novel mutation in the mitochondrial tRNA(Ser(UCN)) gene in a family with non-syndromic sensorineural hearing impairment.
Journal of medical genetics 2000;37(9):692-4.
2000: Delyth J Goodwin; Kersten T Hall; Mathew S Giles; Michael A Calderwood; Alexander F Markham; Adrian Whitehouse
The carboxy terminus of the herpesvirus saimiri ORF 57 gene contains domains that are required for transactivation and transrepression.
The Journal of general virology 2000;81(Pt 9):2253-65.
2000: AJ Stevenson; Mathew S Giles; Kersten T Hall; Delyth J Goodwin; Michael A Calderwood; Alexander F Markham; Adrian Whitehouse
Specific oncolytic activity of herpesvirus saimiri in pancreatic cancer cells.
British journal of cancer 2000;83(3):329-32.
2000: Kersten T Hall; Mathew S Giles; Delyth J Goodwin; Michael A Calderwood; Ian Carr; AJ Stevenson; Alexander F Markham; Adrian Whitehouse
Analysis of gene expression in a human cell line stably transduced with herpesvirus saimiri.
Journal of virology 2000;74(16):7331-7.
2000: AJ Stevenson; E Frolova-Jones; Kersten T Hall; Sally E Kinsey; Alexander F Markham; Adrian Whitehouse; David M Meredith
A herpesvirus saimiri-based gene therapy vector with potential for use in cancer immunotherapy.
Cancer gene therapy 2000;7(7):1077-85.
2000: RC Macadam; Abeezar I Sarela; SM Farmery; P A Robinson; Alexander F Markham; Pierre J Guillou
Death from early colorectal cancer is predicted by the presence of transcripts of the REG gene family.
British journal of cancer 2000;83(2):188-95.
2000: Adam P Booth; Rashida Anwar; H Chen; Amanda J Churchill; J Jay; J Polansky; T Nguyen; Alexander F Markham
Genetic screening in a large family with juvenile onset primary open angle glaucoma.
The British journal of ophthalmology 2000;84(7):722-6.
2000: AH Mansur; G Christie; A Turner; D Timothy Bishop; Alexander F Markham; Peter J Helms; J F J Morrison
Lack of linkage between chromosome 5q23-33 markers and IgE/bronchial hyperreactivity in 67 Scottish families.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(7):954-61.
2000: Amanda J Churchill; Isabel M Hanson; Alexander F Markham
Prenatal diagnosis of aniridia.
Ophthalmology 2000;107(6):1153-6.
2000: Abeezar I Sarela; RC Macadam; SM Farmery; Alexander F Markham; Pierre J Guillou
Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma.
Gut 2000;46(5):645-50.
2000: Helen C Ardley; TP Moynihan; Alexander F Markham; Philip A Robinson
Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7.
Biochimica et biophysica acta 2000;1491(1-3):57-64.
2000: Jon M Askham; PM Moncur; Alexander F Markham; Ewan E Morrison
Regulation and function of the interaction between the APC tumour suppressor protein and EB1.
Oncogene 2000;19(15):1950-8.
2000: Duncan P McHale; Andrew P Jackson; Malcolm Levene; Peter Corry; C Geoffrey Woods; NJ Lench; Robert F Mueller; Alexander F Markham
A gene for ataxic cerebral palsy maps to chromosome 9p12-q12.
European journal of human genetics : EJHG 2000;8(4):267-72.
2000: A L Norris; PM Clissold; Jon M Askham; Ewan E Morrison; PM Moncur; S H McCall; P Louise Coletta; DM Meredith; Alexander F Markham
Truncated adenomatous polyposis coli (APC) tumour suppressor protein can undergo tyrosine phosphorylation.
European journal of cancer (Oxford, England : 1990) 2000;36(4):525-32.
2000: Alan J Mighell; Neil R Smith; Philip A Robinson; Alexander F Markham
Vertebrate pseudogenes.
FEBS letters 2000;468(2-3):109-14.
2000: D Sundaramurthy; LF Pieri; H Gape; Alexander F Markham; DA Campbell
Analysis of the serotonin transporter gene linked polymorphism (5-HTTLPR) in anorexia nervosa.
American journal of medical genetics 2000;96(1):53-5.
2000: BH Maraj; Jack P Leek; Ian Carr; Alexander F Markham
Identification of a novel microsatellite marker tightly linked to the KAI-1 gene for predicting prostate cancer progression.
European urology 2000;37(2):228-33.
2000: Keith S Chapple; EJ Cartwright; Gillian Hawcroft; A Tisbury; Constanze Bonifer; Nigel Scott; A C Windsor; Pierre J Guillou; Alexander F Markham; P Louise Coletta; Mark A Hull
Localization of cyclooxygenase-2 in human sporadic colorectal adenomas.
The American journal of pathology 2000;156(2):545-53.
2000: Nancy G S Tan; Helen C Ardley; Stephen A Rose; Jack P Leek; Alexander F Markham; Philip A Robinson
Characterisation of the human and mouse orthologues of the Drosophila ariadne gene.
Cytogenetics and cell genetics 2000;90(3-4):242-5.
2000: Helen C Ardley; Stephen A Rose; N Tan; Jack P Leek; Alexander F Markham; Philip A Robinson
Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12.
Cytogenetics and cell genetics 2000;89(1-2):137-40.
2000: MA Aldersley; PJ Hamlin; Pam Jones; Alexander F Markham; P A Robinson; Peter D Howdle
No polymorphism in the tissue transglutaminase gene detected in coeliac disease patients.
Scandinavian journal of gastroenterology 2000;35(1):61-3.
1999: Delyth J Goodwin; Kersten T Hall; AJ Stevenson; Alexander F Markham; Adrian Whitehouse
The open reading frame 57 gene product of herpesvirus saimiri shuttles between the nucleus and cytoplasm and is involved in viral RNA nuclear export.
Journal of virology 1999;73(12):10519-24.
1999: Kersten T Hall; AJ Stevenson; Delyth J Goodwin; P C Gibson; Alexander F Markham; Adrian Whitehouse
The activation domain of herpesvirus saimiri R protein interacts with the TATA-binding protein.
Journal of virology 1999;73(12):9756-63.
1999: TP Moynihan; Helen C Ardley; U Nuber; Stephen A Rose; Pam Jones; Alexander F Markham; Martin Scheffner; Philip A Robinson
The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1.
The Journal of biological chemistry 1999;274(43):30963-8.
1999: PJ Hamlin; P Komolmit; Kieran L Bransfield; Pam Jones; N R Smith; MA Aldersley; Peter D Howdle; Alexander F Markham; Philip A Robinson
Identification of multiple candidate genes for IBD susceptibility using high-density transcript mapping in the IBD2 locus on chromosome 12q.
Gastroenterology 1999;117(4):1029-31.
1999: Emma Roberts; Andrew P Jackson; A C Carradice; VJ Deeble; Jovaria Mannan; Yasmin Rashid; Hussain Jafri; Duncan P McHale; Alexander F Markham; NJ Lench; C Geoffrey Woods
The second locus for autosomal recessive primary microcephaly (MCPH2) maps to chromosome 19q13.1-13.2.
European journal of human genetics : EJHG 1999;7(7):815-20.
1999: Louise Gallivan; Alexander F Markham; Rashida Anwar
The Leu564 factor XIIIA variant results in significantly lower plasma factor XIII levels than the Pro564 variant.
Thrombosis and haemostasis 1999;82(4):1368-70.
1999: TP Moynihan; U Nuber; Helen C Ardley; Stephen A Rose; Alexander F Markham; Martin Scheffner; Philip A Robinson
Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(10):977-82.
1999: EA Telford; LM Moynihan; Alexander F Markham; NJ Lench
Isolation and characterisation of a cDNA encoding the precursor for a novel member of the acyl-CoA dehydrogenase gene family.
Biochimica et biophysica acta 1999;1446(3):371-6.
1999: F Syed; SJ Blakemore; Don M Wallace; MK Trower; M Johnson; Alexander F Markham; J F J Morrison
CCR7 (EBI1) receptor down-regulation in asthma: differential gene expression in human CD4+ T lymphocytes.
QJM : monthly journal of the Association of Physicians 1999;92(8):463-71.
1999: JL Curran; WJ Hall; P Jane Halsall; Philip M Hopkins; David E Iles; Alexander F Markham; S H McCall; Rachel L Robinson; SP West; Leslie R Bridges; Francis Richard Ellis
Segregation of malignant hyperthermia, central core disease and chromosome 19 markers.
British journal of anaesthesia 1999;83(2):217-22.
1999: Abeezar I Sarela; SM Farmery; Alexander F Markham; Pierre J Guillou
The candidate tumour suppressor gene, ING1, is retained in colorectal carcinomas.
European journal of cancer (Oxford, England : 1990) 1999;35(8):1264-7.
1999: CM Brewer; Jack P Leek; A J Green; S Holloway; David T Bonthron; Alexander F Markham; David R FitzPatrick
A locus for isolated cleft palate, located on human chromosome 2q32.
American journal of human genetics 1999;65(2):387-96.
1999: AH Mansur; Tim BISHOP; Alexander F Markham; N E Morton; S T Holgate; J F J Morrison
Suggestive evidence for genetic linkage between IgE phenotypes and chromosome 14q markers.
American journal of respiratory and critical care medicine 1999;159(6):1796-802.
1999: M Cooper; Delyth J Goodwin; Kersten T Hall; AJ Stevenson; David M Meredith; Alexander F Markham; Adrian Whitehouse
The gene product encoded by ORF 57 of herpesvirus saimiri regulates the redistribution of the splicing factor SC-35.
The Journal of general virology 1999;80 ( Pt 5)():1311-6.
1999: Mark A Hull; J K Booth; A Tisbury; Nigel Scott; Constanze Bonifer; Alexander F Markham; P Louise Coletta
Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice.
British journal of cancer 1999;79(9-10):1399-405.
1999: AJ Stevenson; M Cooper; J C Griffiths; P C Gibson; Adrian Whitehouse; E F Jones; Alexander F Markham; Sally E Kinsey; David M Meredith
Assessment of Herpesvirus saimiri as a potential human gene therapy vector.
Journal of medical virology 1999;57(3):269-77.
1999: Duncan P McHale; S Mitchell; SE Bundey; LM Moynihan; DA Campbell; C Geoffrey Woods; NJ Lench; Robert F Mueller; Alexander F Markham
A gene for autosomal recessive symmetrical spastic cerebral palsy maps to chromosome 2q24-25.
American journal of human genetics 1999;64(2):526-32.
1999: Rashida Anwar; Louise Gallivan; S D Edmonds; Alexander F Markham
Genotype/phenotype correlations for coagulation factor XIII: specific normal polymorphisms are associated with high or low factor XIII specific activity.
Blood 1999;93(3):897-905.
1999: Sandra M Bell; Wai K Lam; Ian Carr; EJ Cartwright; K Pinchin; S Wedgwood; Alexander F Markham; P Louise Coletta
Assignment of the murine adenomatous polyposis coli 2 (Apc2) gene to mouse chromosome band 10B5-C2 by in situ hybridisation.
Cytogenetics and cell genetics 1999;86(1):81-2.
1999: Konstantina Grosios; Jack P Leek; Alexander F Markham; George D Yancopoulos; Pam Jones
Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping.
Cytogenetics and cell genetics 1999;84(1-2):118-20.
1999: DA Campbell; D Sundaramurthy; D Gordon; Alexander F Markham; LF Pieri
Association between a marker in the UCP-2/UCP-3 gene cluster and genetic susceptibility to anorexia nervosa.
Molecular psychiatry 1999;4(1):68-70.
1998: Ewan E Morrison; B N Wardleworth; Jon M Askham; Alexander F Markham; DM Meredith
EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle.
Oncogene 1998;17(26):3471-7.
1998: Ian Carr; Adrian Whitehouse; P Louise Coletta; Alexander F Markham
Structural and evolutionary characterization of the human sorbitol dehydrogenase gene duplication.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(12):1042-8.
1998: Rashida Anwar; Louise Gallivan; KJ Miloszewski; Alexander F Markham
Splicing and missense mutations in the human FXIIIA gene causing FXIII deficiency: effects of these mutations on FXIIIA RNA processing and protein structure.
British journal of haematology 1998;103(2):425-8.
1998: MA Aldersley; V Allgar; Peter D Howdle; Alexander F Markham
Haemochromatosis and type 2 diabetes.
Lancet 1998;352(9133):1067-8.
1998: F Syed; B Bingham; M Johnson; Alexander F Markham; J F J Morrison
The CD4+ T lymphocyte is a site of steroid resistance in asthma.
QJM : monthly journal of the Association of Physicians 1998;91(8):567-72.
1998: Andrew P Jackson; Duncan P McHale; DA Campbell; Hussain Jafri; Yasmin Rashid; Jovaria Mannan; Gulshan Karbani; Peter Corry; Malcolm Levene; Robert F Mueller; Alexander F Markham; NJ Lench; C Geoffrey Woods
Primary autosomal recessive microcephaly (MCPH1) maps to chromosome 8p22-pter.
American journal of human genetics 1998;63(2):541-6.
1998: Rashida Anwar; KJ Miloszewski; Alexander F Markham
New splicing mutations in the human factor XIIIA gene, each producing multiple mutant transcripts of varying abundance.
Thrombosis and haemostasis 1998;79(6):1151-6.
1998: LM Moynihan; SE Bundey; D Heath; E L Jones; Duncan P McHale; Robert F Mueller; Alexander F Markham; NJ Lench
Autozygosity mapping, to chromosome 11q25, of a rare autosomal recessive syndrome causing histiocytosis, joint contractures, and sensorineural deafness.
American journal of human genetics 1998;62(5):1123-8.
1998: S J Mitchell; Duncan P McHale; DA Campbell; NJ Lench; Robert F Mueller; SE Bundey; Alexander F Markham
A syndrome of severe mental retardation, spasticity, and tapetoretinal degeneration linked to chromosome 15q24.
American journal of human genetics 1998;62(5):1070-6.
1998: Sandra M Bell; C Bennett; Alexander F Markham; NJ Lench
Evidence for a common mutation in hereditary pancreatitis.
Molecular pathology : MP 1998;51(2):115-7.
1998: BH Maraj; P Whelan; Alexander F Markham
Prostate-specific membrane antigen.
British journal of urology 1998;81(4):523-8.
1998: Bruce E Hayward; N Dunlop; S Intody; Jack P Leek; Alexander F Markham; JP Warner; David T Bonthron
Organization of the human glucokinase regulator gene GCKR.
Genomics 1998;49(1):137-42.
1998: R Robinson; JL Curran; WJ Hall; P Jane Halsall; Philip M Hopkins; Alexander F Markham; AD Stewart; SP West; Francis Richard Ellis
Genetic heterogeneity and HOMOG analysis in British malignant hyperthermia families.
Journal of medical genetics 1998;35(3):196-201.
1998: DA Campbell; D Sundaramurthy; Alexander F Markham; LF Pieri
Lack of association between 5-HT2A gene promoter polymorphism and susceptibility to anorexia nervosa.
Lancet 1998;351(9101):499.
1998: AH Mansur; D Timothy Bishop; Alexander F Markham; J Britton; J F J Morrison
Association study of asthma and atopy traits and chromosome 5q cytokine cluster markers.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28(2):141-50.
1998: NJ Lench; Alexander F Markham; Robert F Mueller; David P Kelsell; R J Smith; Patrick J Willems; Isabelle Schatteman; H Capon; P J Van De Heyning; Guy Van Camp
A Moroccan family with autosomal recessive sensorineural hearing loss caused by a mutation in the gap junction protein gene connexin 26 (GJB2).
Journal of medical genetics 1998;35(2):151-2.
1998: EA Telford; Patrick J Wightman; Jack P Leek; Alexander F Markham; NJ Lench; David T Bonthron
cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C.
Biochemical and biophysical research communications 1998;242(2):407-12.
1998: Philip A Robinson; Jack P Leek; Helen C Ardley; J Thompson; Stephen A Rose; Alexander F Markham
Assignment of UBE2D1 to human chromosome bands 10q11.2-->q21 by in situ hybridization.
Cytogenetics and cell genetics 1998;83(3-4):247-8.
1998: Philip A Robinson; P Lomonte; Alexander F Markham; R D Everett
Assignment1 of herpesvirus-associated ubiquitin-specific protease gene HAUSP to human chromosome band 16p13.3 by in situ hybridization.
Cytogenetics and cell genetics 1998;83(1-2):100.
1998: Stephen A Rose; Jack P Leek; TP Moynihan; Helen C Ardley; Alexander F Markham; Philip A Robinson
Assignment1 of the ubiquitin conjugating enzyme gene, UBE2G2, to human chromosome band 21q22.3 by in situ hybridization.
Cytogenetics and cell genetics 1998;83(1-2):98-9.
1998: PJ Hamlin; Pam Jones; Jack P Leek; Kieran L Bransfield; NJ Lench; MA Aldersley; Peter D Howdle; Alexander F Markham; Philip A Robinson
Assignment of GALGT encoding beta-1, 4N-acetylgalactosaminyl-transferase (GalNAc-T) and KIF5A encoding neuronal kinesin (D12S1889) to human chromosome band 12q13 by assignment to ICI YAC 26EG10 and in situ hybridization. medjph@stjames.leeds.ac.uk.
Cytogenetics and cell genetics 1998;82(3-4):267-8.
1998: Helen C Ardley; Alexander F Markham; Philip A Robinson
Fine mapping of 12 previously unassigned EST clones to individual YACs in the familial Alzheimer's disease (FAD) region of chromosome 14q24.3.
Cytogenetics and cell genetics 1998;82(1-2):107-9.
1998: D Sundaramurthy; DA Campbell; Jack P Leek; Alexander F Markham; LF Pieri
Assignment of the melanocortin 4 receptor (MC4R) gene to human chromosome band 18q22 by in situ hybridisation and radiation hybrid mapping.
Cytogenetics and cell genetics 1998;82(1-2):97-8.
1998: BH Maraj; Jack P Leek; MK Karayi; M Ali; NJ Lench; Alexander F Markham
Detailed genetic mapping around a putative prostate-specific membrane antigen locus on human chromosome 11p11.2.
Cytogenetics and cell genetics 1998;81(1):3-9.
1998: Amanda J Churchill; Adam P Booth; Rashida Anwar; Alexander F Markham
PAX 6 is normal in most cases of Peters' anomaly.
Eye (London, England) 1998;12 ( Pt 2)():299-303.
1998: Rashida Anwar; KJ Miloszewski; Alexander F Markham
Identification of a large deletion, spanning exons 4 to 11 of the human factor XIIIA gene, in a factor XIII-deficient family.
Blood 1998;91(1):149-53.
1997: DA Campbell; Duncan P McHale; K A Brown; LM Moynihan; MJ Houseman; Gulshan Karbani; G Parry; A H Janjua; VE Newton; Lihadh Al-Gazali; Alexander F Markham; NJ Lench; Robert F Mueller
A new locus for non-syndromal, autosomal recessive, sensorineural hearing loss (DFNB16) maps to human chromosome 15q21-q22.
Journal of medical genetics 1997;34(12):1015-7.
1997: Alan J Mighell; Alexander F Markham; Philip A Robinson
Alu sequences.
FEBS letters 1997;417(1):1-5.
1997: Ewan E Morrison; Jon M Askham; PM Clissold; Alexander F Markham; DM Meredith
The cellular distribution of the adenomatous polyposis coli tumour suppressor protein in neuroblastoma cells is regulated by microtubule dynamics.
Neuroscience 1997;81(2):553-63.
1997: Ewan E Morrison; Jon M Askham; PM Clissold; Alexander F Markham; DM Meredith
Expression of beta-catenin and the adenomatous polyposis coli tumour suppressor protein in mouse neocortical cells in vitro.
Neuroscience letters 1997;235(3):129-32.
1997: NJ Lench; EA Telford; Alec S High; Alexander F Markham; Carol Wicking; Brandon J Wainwright
Characterisation of human patched germ line mutations in naevoid basal cell carcinoma syndrome.
Human genetics 1997;100(5-6):497-502.
1997: Neil R Smith; A Li; MA Aldersley; Alec S High; Alexander F Markham; Philip A Robinson
Rapid determination of the complexity of cDNA bands extracted from DDRT-PCR polyacrylamide gels.
Nucleic acids research 1997;25(17):3552-4.
1997: Rashida Anwar; John W L Puntis; Alexander F Markham
A new mutation in the human lipoprotein lipase gene causing familial hyperchylomicronaemia.
Molecular pathology : MP 1997;50(4):221-3.
1997: MA Aldersley; T E James; Alexander F Markham; Peter D Howdle
Coeliac disease and Behçet's disease.
The British journal of ophthalmology 1997;81(8):710.
1997: K A Brown; Lihadh Al-Gazali; LM Moynihan; NJ Lench; Alexander F Markham; Robert F Mueller
Genetic heterogeneity in Schwartz-Jampel syndrome: two families with neonatal Schwartz-Jampel syndrome do not map to human chromosome 1p34-p36.1.
Journal of medical genetics 1997;34(8):685-7.
1997: Neil R Smith; MA Aldersley; A Li; Alec S High; TP Moynihan; Alexander F Markham; Philip A Robinson
Automated differential display using a fluorescently labeled universal primer.
BioTechniques 1997;23(2):274-9.
1997: R B Harun; K K Smith; Jack P Leek; Alexander F Markham; A Norris; J F J Morrison
Characterization of human SHC p66 cDNA and its processed pseudogene mapping to Xq12-q13.1.
Genomics 1997;42(2):349-52.
1997: Ian Carr; Alexander F Markham; P Louise Coletta
Identification and characterisation of a sequence related to human sorbitol dehydrogenase.
European journal of biochemistry / FEBS 1997;245(3):760-7.
1997: Adrian Whitehouse; J Deeble; R Parmar; Graham Taylor; Alexander F Markham; D M Meredith
Analysis of the mismatch and insertion/deletion binding properties of Thermus thermophilus, HB8, MutS.
Biochemical and biophysical research communications 1997;233(3):834-7.
1997: MA Aldersley; Peter D Howdle; Judy I Wyatt; P A Robinson; Alexander F Markham
Haemochromatosis gene mutation in liver disease patients.
Lancet 1997;349(9057):1025-6.
1997: NJ Lench; RC Macadam; Alexander F Markham
The human gene encoding FKBP-rapamycin associated protein (FRAP) maps to chromosomal band 1p36.2.
Human genetics 1997;99(4):547-9.
1997: Adrian Whitehouse; J Deeble; Graham Taylor; P J Guillou; S E Phillips; D M Meredith; Alexander F Markham
Mapping the minimal domain of hMSH-2 sufficient for binding mismatched oligonucleotides.
Biochemical and biophysical research communications 1997;232(1):10-3.
1997: Rashida Anwar; S G Gilbey; J P New; Alexander F Markham
Male pseudohermaphroditism resulting from a novel mutation in the human steroid 5 alpha-reductase type 2 gene (SRD5A2).
Molecular pathology : MP 1997;50(1):51-2.
1997: Bruce E Hayward; JP Warner; N Dunlop; Judy A Fantes; S Intody; Jack P Leek; Alexander F Markham; David T Bonthron
Molecular genetics of the human glucokinase regulator-fructokinase (GCKR-KHK) region of chromosome 2p23.
Biochemical Society transactions 1997;25(1):140-5.
1997: DA Campbell; D Sundaramurthy; Alexander F Markham; LF Pieri
Fine mapping of the human 5-HTR2a gene to chromosome 13q14 and identification of two highly polymorphic linked markers suitable for association studies in psychiatric disorders.
Genetic testing 1997;1(4):297-9.
1997: Jack P Leek; Ian Carr; Sandra M Bell; Alexander F Markham; NJ Lench
Assignment of the DNA fragmentation factor gene (DFFA) to human chromosome bands 1p36.3-->p36.2 by in situ hybridization.
Cytogenetics and cell genetics 1997;79(3-4):212-3.
1997: Helen C Ardley; TP Moynihan; J Thompson; Jack P Leek; Alexander F Markham; Philip A Robinson
Rapid isolation of genomic clones for individual members of human multigene families: identification and localisation of UBE2L4, a novel member of a ubiquitin conjugating enzyme dispersed gene family.
Cytogenetics and cell genetics 1997;79(3-4):188-92.
1997: Jack P Leek; TP Moynihan; Rashida Anwar; David T Bonthron; Alexander F Markham; NJ Lench
Assignment of Indian hedgehog (IHH) to human chromosome bands 2q33-->q35 by in situ hybridization.
Cytogenetics and cell genetics 1997;76(3-4):187-8.
1996: Adrian Whitehouse; R Parmar; J Deeble; Graham Taylor; S E Phillips; D M Meredith; Alexander F Markham
Mutational analysis of the nucleotide binding domain of the mismatch repair enzyme hMSH-2.
Biochemical and biophysical research communications 1996;229(1):147-53.
1996: NJ Lench; EA Telford; S E Andersen; TP Moynihan; Philip A Robinson; Alexander F Markham
An EST and STS-based YAC contig map of human chromosome 9q22.3.
Genomics 1996;38(2):199-205.
1996: P Louise Coletta; E J Cartwright; Alexander F Markham
Transgenic models and cancer treatment.
Cancer treatment reviews 1996;21(6):565-76.
1996: TP Moynihan; Alexander F Markham; Philip A Robinson
Genomic analysis of human multigene families using chromosome-specific vectorette PCR.
Nucleic acids research 1996;24(20):4094-5.
1996: S E Andersen; NJ Lench; Alexander F Markham
YAC clones that extend the human chromosome 12cen-12q15 region contig map.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(10):780-3.
1996: K A Brown; Jack P Leek; NJ Lench; LM Moynihan; Alexander F Markham; Robert F Mueller
Human sequences homologous to the gene for the cochlear protein Ocp-II do not map to currently known non-syndromic hearing loss loci.
Annals of human genetics 1996;60(Pt 5):385-9.
1996: Adrian Whitehouse; Graham Taylor; J Deeble; S E Phillips; D M Meredith; Alexander F Markham
A carboxy terminal domain of the hMSH-2 gene product is sufficient for binding specific mismatched oligonucleotides.
Biochemical and biophysical research communications 1996;225(1):289-95.
1996: TP Moynihan; Helen C Ardley; Jack P Leek; J Thompson; N S Brindle; Alexander F Markham; Philip A Robinson
Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(7):520-5.
1996: NJ Lench; A Norris; A Bailey; A Booth; Alexander F Markham
Vectorette PCR isolation of microsatellite repeat sequences using anchored dinucleotide repeat primers.
Nucleic acids research 1996;24(11):2190-1.
1996: Bruce E Hayward; Judy A Fantes; JP Warner; S Intody; Jack P Leek; Alexander F Markham; David T Bonthron
Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(6):454-8.
1996: Philip A Robinson; Jack P Leek; Ian Carr; A Bailey; NJ Lench; J Morrison; WJ Hume; Alec S High; Alexander F Markham
Yeast artificial chromosome cloning and chromosomal localization of the abundant odontogenic keratocyst protein elafin.
Archives of oral biology 1996;41(5):445-52.
1996: NJ Lench; Alec S High; Alexander F Markham; WJ Hume; Philip A Robinson
Investigation of chromosome 9q22.3-q31 DNA marker loss in odontogenic keratocysts.
European journal of cancer. Part B, Oral oncology 1996;32B(3):202-6.
1996: Rashida Anwar; TP Moynihan; Helen C Ardley; N Brindle; P Louise Coletta; Nigel J Cairns; Alexander F Markham; Philip A Robinson
Molecular analysis of the presenilin 1 (S182) gene in "sporadic" cases of Alzheimer's disease: identification and characterisation of unusual splice variants.
Journal of neurochemistry 1996;66(4):1774-7.
1996: A L Norris; A Bailey; Jon M Askham; Adrian Whitehouse; P M Clissold; Alexander F Markham; D M Meredith
Characterization of the human beta-catenin gene.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(2):160-2.
1996: K A Brown; A H Janjua; Gulshan Karbani; G Parry; A Noble; G Crockford; Tim BISHOP; VE Newton; Alexander F Markham; Robert F Mueller
Linkage studies of non-syndromic recessive deafness (NSRD) in a family originating from the Mirpur region of Pakistan maps DFNB1 centromeric to D13S175.
Human molecular genetics 1996;5(1):169-73.
1995: Rashida Anwar; A D Stewart; KJ Miloszewski; M S Losowsky; Alexander F Markham
Molecular basis of inherited factor XIII deficiency: identification of multiple mutations provides insights into protein function.
British journal of haematology 1995;91(3):728-35.
1995: Philip A Robinson; Jack P Leek; J Thompson; Ian Carr; A Bailey; TP Moynihan; P Louise Coletta; NJ Lench; Alexander F Markham
A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(10):725-31.
1995: Ian Carr; Alexander F Markham
Molecular genetic analysis of the human sorbitol dehydrogenase gene.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(9):645-52.
1995: N J Lench; J Thompson; Alexander F Markham; P A Robinson
(CGG) trinucleotide repeat polymorphism in the 5' region of the HHR6B gene: the human homolog of the yeast DNA repair gene RAD6.
Human genetics 1995;96(3):369-70.
1995: JP Warner; Jack P Leek; S Intody; Alexander F Markham; David T Bonthron
Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(8):532-6.
1995: A Bailey; A L Norris; Jack P Leek; P M Clissold; Ian Carr; D J Ogilvie; J F Morrison; D M Meredith; Alexander F Markham
Yeast artificial chromosome cloning of the beta-catenin locus on human chromosome 3p21-22.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 1995;3(3):201-3.
1994: P Louise Coletta; NJ Lench; K A Brown; Alexander F Markham
Comparative genetic mapping for the identification of novel diagnostic and therapeutic targets.
Current opinion in biotechnology 1994;5(6):643-7.
1994: Alexander F Markham; P Louise Coletta; Philip A Robinson; P Clissold; Graham Taylor; Ian Carr; D M Meredith
Screening for cancer predisposition.
European journal of cancer (Oxford, England : 1990) 1994;30A(13):2015-29.