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George Markham

Research Profile

Chemicals & Drugs

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Escherichia coli

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Thermodynamics

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Publications

TOP 3
Krishna L Bhat; Joseph D Larkin; George D Markham; Charles W Bock
Thermodynamics of boroxine formation from the aliphatic boronic acid monomers R-B(OH)2 (R = H, H3C, H2N, HO, and F): a computational investigation.
George D Markham; Fusao Takusagawa; Anthony M Dijulio; Charles W Bock
An investigation of the catalytic mechanism of S-adenosylmethionine synthetase by QM/MM calculations.
John C Taylor; Charles W Bock; Fusao Takusagawa; George D Markham
Discovery of novel types of inhibitors of S-adenosylmethionine synthesis by virtual screening.

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All Publications

2011: Krishna L Bhat; Joseph D Larkin; George D Markham; Charles W Bock
Thermodynamics of boroxine formation from the aliphatic boronic acid monomers R-B(OH)2 (R = H, H3C, H2N, HO, and F): a computational investigation.
The journal of physical chemistry. A 2011;115(26):7785-93.
2009: George D Markham; Fusao Takusagawa; Anthony M Dijulio; Charles W Bock
An investigation of the catalytic mechanism of S-adenosylmethionine synthetase by QM/MM calculations.
Archives of biochemistry and biophysics 2009;492(1-2):82-92.
2009: John C Taylor; Charles W Bock; Fusao Takusagawa; George D Markham
Discovery of novel types of inhibitors of S-adenosylmethionine synthesis by virtual screening.
Journal of medicinal chemistry 2009;52(19):5967-73.
2009: Maxim Pimkin; Julia Pimkina; George D Markham
A regulatory role of the Bateman domain of IMP dehydrogenase in adenylate nucleotide biosynthesis.
The Journal of biological chemistry 2009;284(12):7960-9.
2009: George D Markham; M A Pajares
Structure-function relationships in methionine adenosyltransferases.
Cellular and molecular life sciences : CMLS 2009;66(4):636-48.
2009: Maxim Pimkin; George D Markham
Inosine 5'-monophosphate dehydrogenase.
Advances in enzymology and related areas of molecular biology 2009;76():1-53.
2008: Joseph D Larkin; Krishna L Bhat; George D Markham; Tony James; Bernard Brooks; Charles W Bock
A computational characterization of boron-oxygen multiple bonding in HN=CH-CH=CH-NH-BO.
The journal of physical chemistry. A 2008;112(36):8446-54.
2008: Sarah H Lawrence; Ursula D Ramirez; Lei Tang; Farit Fazliyez; Lenka Kundrat; George D Markham; Eileen K Jaffe
Shape shifting leads to small-molecule allosteric drug discovery.
Chemistry & biology 2008;15(6):586-96.
2008: Maxim Pimkin; George D Markham
The CBS subdomain of inosine 5'-monophosphate dehydrogenase regulates purine nucleotide turnover.
Molecular microbiology 2008;68(2):342-59.
2008: Joseph D Larkin; Matt Milkevitch; Krishna L Bhat; George D Markham; Bernard Brooks; Charles W Bock
Dimers of boroglycine and methylamine boronic acid: a computational comparison of the relative importance of dative versus hydrogen bonding.
The journal of physical chemistry. A 2008;112(1):125-33.
2007: Joseph D Larkin; Krishna L Bhat; George D Markham; Bernard Brooks; Jack H Lai; Charles W Bock
A computational investigation of the geometrical structure and protodeboronation of boroglycine, H2N-CH2-B(OH)2.
The journal of physical chemistry. A 2007;111(28):6489-500.
2007: Zichun J Lu; George D Markham
Metal ion activation of S-adenosylmethionine decarboxylase reflects cation charge density.
Biochemistry 2007;46(27):8172-80.
2006: Joseph D Larkin; Krishna L Bhat; George D Markham; Bernard Brooks; Henry F Schaefer; Charles W Bock
Structure of the boronic acid dimer and the relative stabilities of its conformers.
The journal of physical chemistry. A 2006;110(36):10633-42.
2004: George D Markham; Robert S Reczkowski
Structural studies of inhibition of S-adenosylmethionine synthetase by slow, tight-binding intermediate and product analogues.
Biochemistry 2004;43(12):3415-25.
2004: Junichi Komoto; Taro Yamada; Yoshimi Takata; George D Markham; Fusao Takusagawa
Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of S-adenosylmethionine synthesis from ATP and Met.
Biochemistry 2004;43(7):1821-31.
2004: Zichun J Lu; George D Markham
Catalytic properties of the archaeal S-adenosylmethionine decarboxylase from Methanococcus jannaschii.
The Journal of biological chemistry 2004;279(1):265-73.
2003: Ahmad L Subhi; Paula Diegelman; Carl W Porter; Baiqing Tang; Zichun J Lu; George D Markham; warren kruger
Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites.
The Journal of biological chemistry 2003;278(50):49868-73.
2003: John C Taylor; George D Markham
Conformational dynamics of the active site loop of S-adenosylmethionine synthetase illuminated by site-directed spin labeling.
Archives of biochemistry and biophysics 2003;415(2):164-71.
2003: Charles W Bock; George D Markham; Amy K Katz; Jenny P Glusker
The arrangement of first- and second-shell water molecules in trivalent aluminum complexes: results from density functional theory and structural crystallography.
Inorganic chemistry 2003;42(5):1538-48.
2002: John C Taylor; Fusao Takusagawa; George D Markham
The active site loop of S-adenosylmethionine synthetase modulates catalytic efficiency.
Biochemistry 2002;41(30):9358-69.
2002: George D Markham; Per-Ola Norrby; Charles W Bock
S-adenosylmethionine conformations in solution and in protein complexes: conformational influences of the sulfonium group.
Biochemistry 2002;41(24):7636-46.
2002: Zichun J Lu; George D Markham
Enzymatic properties of S-adenosylmethionine synthetase from the archaeon Methanococcus jannaschii.
The Journal of biological chemistry 2002;277(19):16624-31.
2001: Mendel Trachtman; George D Markham; Jenny P Glusker; P George; Charles W Bock
Interactions of metal ions with water: ab initio molecular orbital studies of structure, vibrational frequencies, charge distributions, bonding enthalpies, and deprotonation enthalpies. 2. Monohydroxides.
Inorganic chemistry 2001;40(17):4230-41.
2000: A D Kim; David E Graham; Steven H Seeholzer; George D Markham
S-Adenosylmethionine decarboxylase from the archaeon Methanococcus jannaschii: identification of a novel family of pyruvoyl enzymes.
Journal of bacteriology 2000;182(23):6667-72.
2000: Fiorella Petronzelli; A Riccio; George D Markham; Steven H Seeholzer; Maurizio Genuardi; M Karbowski; anthony yeung; Yoshihiro Matsumoto; Alfonso Bellacosa
Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain.
Journal of cellular physiology 2000;185(3):473-80.
2000: Fiorella Petronzelli; A Riccio; George D Markham; Steven H Seeholzer; J Stoerker; Maurizio Genuardi; anthony yeung; Yoshihiro Matsumoto; Alfonso Bellacosa
Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase.
The Journal of biological chemistry 2000;275(42):32422-9.
2000: C Satishchandran; George D Markham
Mechanistic studies of Escherichia coli adenosine-5'-phosphosulfate kinase.
Archives of biochemistry and biophysics 2000;378(2):210-5.
2000: M S McQueney; K S Anderson; George D Markham
Energetics of S-adenosylmethionine synthetase catalysis.
Biochemistry 2000;39(15):4443-54.
2000: John C Taylor; George D Markham
The bifunctional active site of S-adenosylmethionine synthetase. Roles of the basic residues.
The Journal of biological chemistry 2000;275(6):4060-5.
2000: David E Graham; C L Bock; C Schalk-Hihi; Zichun J Lu; George D Markham
Identification of a highly diverged class of S-adenosylmethionine synthetases in the archaea.
The Journal of biological chemistry 2000;275(6):4055-9.
1999: John C Taylor; George D Markham
The bifunctional active site of s-adenosylmethionine synthetase. Roles of the active site aspartates.
The Journal of biological chemistry 1999;274(46):32909-14.
1999: Robert S Reczkowski; George D Markham
Slow binding inhibition of S-adenosylmethionine synthetase by imidophosphate analogues of an intermediate and product.
Biochemistry 1999;38(28):9063-8.
1999: George D Markham; C L Bock; C Schalk-Hihi
Acid-base catalysis in the chemical mechanism of inosine monophosphate dehydrogenase.
Biochemistry 1999;38(14):4433-40.
1999: C Schalk-Hihi; George D Markham
The conformations of a substrate and a product bound to the active site of S-adenosylmethionine synthetase.
Biochemistry 1999;38(8):2542-50.
1998: Robert S Reczkowski; John C Taylor; George D Markham
The active-site arginine of S-adenosylmethionine synthetase orients the reaction intermediate.
Biochemistry 1998;37(39):13499-506.
1998: C Schalk-Hihi; Yu-Zhu Zhang; George D Markham
The conformation of NADH bound to inosine 5'-monophosphate dehydrogenase determined by transferred nuclear Overhauser effect spectroscopy.
Biochemistry 1998;37(20):7608-16.
1997: B Xiang; George D Markham
Probing the mechanism of inosine monophosphate dehydrogenase with kinetic isotope effects and NMR determination of the hydride transfer stereospecificity.
Archives of biochemistry and biophysics 1997;348(2):378-82.
1996: B Xiang; George D Markham
The conformation of inosine 5'-monophosphate (IMP) bound to IMP dehydrogenase determined by transferred nuclear overhauser effect spectroscopy.
The Journal of biological chemistry 1996;271(44):27531-5.
1996: B Xiang; John C Taylor; George D Markham
Monovalent cation activation and kinetic mechanism of inosine 5'-monophosphate dehydrogenase.
The Journal of biological chemistry 1996;271(3):1435-40.
1995: S F Silverton; S Mesaros; George D Markham; Tadeusz Malinski
Osteoclast radical interactions: NADPH causes pulsatile release of NO and stimulates superoxide production.
Endocrinology 1995;136(11):5244-7.
1995: Robert S Reczkowski; George D Markham
Structural and functional roles of cysteine 90 and cysteine 240 in S-adenosylmethionine synthetase.
The Journal of biological chemistry 1995;270(31):18484-90.
1995: M S McQueney; George D Markham
Investigation of monovalent cation activation of S-adenosylmethionine synthetase using mutagenesis and uranyl inhibition.
The Journal of biological chemistry 1995;270(31):18277-84.
1995: Eileen K Jaffe; S Ali; L W Mitchell; K M Taylor; M Volin; George D Markham
Characterization of the role of the stimulatory magnesium of Escherichia coli porphobilinogen synthase.
Biochemistry 1995;34(1):244-51.
1993: C Satishchandran; John C Taylor; George D Markham
The ORF1 of the gentamicin-resistance operon (aac) of Pseudomonas aeruginosa encodes adenosine 5'-phosphosulphate kinase.
Molecular microbiology 1993;9(6):1223-7.
1993: C Satishchandran; John C Taylor; George D Markham
Isozymes of S-adenosylmethionine synthetase are encoded by tandemly duplicated genes in Escherichia coli.
Molecular microbiology 1993;9(4):835-46.
1993: George D Markham; C B Myers; K A Harris; M Volin; Eileen K Jaffe
Spatial proximity and sequence localization of the reactive sulfhydryls of porphobilinogen synthase.
Protein science : a publication of the Protein Society 1993;2(1):71-9.
1992: C Satishchandran; Y N Hickman; George D Markham
Characterization of the phosphorylated enzyme intermediate formed in the adenosine 5'-phosphosulfate kinase reaction.
Biochemistry 1992;31(47):11684-8.
1990: Eileen K Jaffe; George D Markham; J S Rajagopalan
15N and 13C NMR studies of ligands bound to the 280,000-dalton protein porphobilinogen synthase elucidate the structures of enzyme-bound product and a Schiff base intermediate.
Biochemistry 1990;29(36):8345-50.
1990: C Satishchandran; George D Markham; R C Moore; Stephen M Boyle
Locations of the speA, speB, speC, and metK genes on the physical map of Escherichia coli.
Journal of bacteriology 1990;172(9):4748.
1990: C Satishchandran; John C Taylor; George D Markham
Novel Escherichia coli K-12 mutants impaired in S-adenosylmethionine synthesis.
Journal of bacteriology 1990;172(8):4489-96.
1989: C Satishchandran; George D Markham
Adenosine-5'-phosphosulfate kinase from Escherichia coli K12. Purification, characterization, and identification of a phosphorylated enzyme intermediate.
The Journal of biological chemistry 1989;264(25):15012-21.
1988: George D Markham; C Satishchandran
Identification of the reactive sulfhydryl groups of S-adenosylmethionine synthetase.
The Journal of biological chemistry 1988;263(18):8666-70.
1988: Eileen K Jaffe; George D Markham
13C NMR studies of methylene and methine carbons of substrate bound to a 280,000-dalton protein, porphobilinogen synthase.
Biochemistry 1988;27(12):4475-81.
1988: Thomas S Leyh; John C Taylor; George D Markham
The sulfate activation locus of Escherichia coli K12: cloning, genetic, and enzymatic characterization.
The Journal of biological chemistry 1988;263(5):2409-16.
1987: Eileen K Jaffe; George D Markham
13C NMR studies of porphobilinogen synthase: observation of intermediates bound to a 280,000-dalton protein.
Biochemistry 1987;26(14):4258-64.
1984: Stephen M Boyle; George D Markham; E W Hafner; J M Wright; Herbert Tabor; Celia White Tabor
Expression of the cloned genes encoding the putrescine biosynthetic enzymes and methionine adenosyltransferase of Escherichia coli (speA, speB, speC and metK).
Gene 1984;30(1-3):129-36.
1983: George D Markham; Celia White Tabor; Herbert Tabor
S-adenosylmethionine decarboxylase (Escherichia coli).
Methods in enzymology 1983;94():228-30.
1983: Celia White Tabor; Herbert Tabor; E W Hafner; George D Markham; Stephen M Boyle
Cloning of the Escherichia coli genes for the biosynthetic enzymes for polyamines.
Methods in enzymology 1983;94():117-21.
1983: George D Markham; E W Hafner; Celia White Tabor; Herbert Tabor
S-adenosylmethionine synthetase (methionine adenosyltransferase) (Escherichia coli).
Methods in enzymology 1983;94():219-22.
1982: George D Markham; Celia White Tabor; Herbert Tabor
S-adenosylmethionine decarboxylase of Escherichia coli. Studies on the covalently linked pyruvate required for activity.
The Journal of biological chemistry 1982;257(20):12063-8.
1980: George D Markham; E W Hafner; Celia White Tabor; Herbert Tabor
S-Adenosylmethionine synthetase from Escherichia coli.
The Journal of biological chemistry 1980;255(19):9082-92.