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Stefan Marklund

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Eiichi Tokuda; Shunsuke Watanabe; Eriko Okawa; Shin-Ichi Ono; Stefan L Marklund
Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities.
Per Zetterström; Peter M Andersen; Thomas Brännström; Karin S Graffmo; Stefan L Marklund
Composition of soluble misfolded superoxide dismutase-1 in murine models of amyotrophic lateral sclerosis.
Karin S Graffmo; Stefan L Marklund; Per Zetterström; Karin Forsberg; Peter M Andersen; Johan Bergh; Anna Birve; Thomas Brännström
Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis.

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2013: Eiichi Tokuda; Shunsuke Watanabe; Eriko Okawa; Shin-Ichi Ono; Stefan L Marklund
Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities.
Neurobiology of disease 2013;54():308-19.
2013: Per Zetterström; Peter M Andersen; Thomas Brännström; Karin S Graffmo; Stefan L Marklund
Composition of soluble misfolded superoxide dismutase-1 in murine models of amyotrophic lateral sclerosis.
Neuromolecular medicine 2013;15(1):147-58.
2013: Karin S Graffmo; Stefan L Marklund; Per Zetterström; Karin Forsberg; Peter M Andersen; Johan Bergh; Anna Birve; Thomas Brännström
Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis.
Human molecular genetics 2013;22(1):51-60.
2012: Eva M Olofsson; Stefan L Marklund; Anders Behndig
Enhanced age-related cataract in copper-zinc superoxide dismutase null mice.
Clinical & experimental ophthalmology 2012;40(8):813-20.
2012: Matthis Synofzik; Christian Wilhelm; Chiara Zecca; Ayse N Basak; Anna Birve; Saskia Biskup; Rubén Fernández-Santiago; Claudio Gobbi; Toomas Kaugesaar; Isil Keskin; Stefan L Marklund; Dario Ronchi; Ludger Schöls; Peter M Andersen
Mutant superoxide dismutase-1 indistinguishable from wild-type causes ALS.
Human molecular genetics 2012;21(16):3568-74.
2012: Kim Ekblom; Göran Hallmans; Stefan L Marklund; Richard Palmqvist; Bethany Van Guelpen; Lars Weinehall; Johan Hultdin
Iron biomarkers in plasma, HFE genotypes, and the risk for colorectal cancer in a prospective setting.
Diseases of the colon and rectum 2012;55(3):337-44.
2012: Anna Wuolikainen; Peter M Andersen; Stefan L Marklund; Thomas Moritz; Henrik Antti
ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations.
Molecular genetics and metabolism 2012;105(3):472-8.
2011: Kim Ekblom; Göran Hallmans; Jan-Håkan Jansson; Stefan L Marklund; Lars Weinehall; Johan Hultdin
Iron stores and HFE genotypes are not related to increased risk of first-time myocardial infarction: a prospective nested case-referent study.
International journal of cardiology 2011;150(2):169-72.
2011: Per Zetterström; Karin S Graffmo; Peter M Andersen; Thomas Brännström; Stefan L Marklund
Proteins that bind to misfolded mutant superoxide dismutase-1 in spinal cords from transgenic amyotrophic lateral sclerosis (ALS) model mice.
The Journal of biological chemistry 2011;286(23):20130-6.
2011: Karin Forsberg; Peter M Andersen; Stefan L Marklund; Thomas Brännström
Glial nuclear aggregates of superoxide dismutase-1 are regularly present in patients with amyotrophic lateral sclerosis.
Acta neuropathologica 2011;121(5):623-34.
2011: Terrell Brotherton; Meraida Polak; Crystal Kelly; Anna Birve; Peter Andersen; Stefan L Marklund; Jonathan D Glass
A novel ALS SOD1 C6S mutation with implications for aggregation related toxicity and genetic counseling.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2011;12(3):215-9.
2011: Per Zetterström; Peter M Andersen; Thomas Brännström; Stefan L Marklund
Misfolded superoxide dismutase-1 in CSF from amyotrophic lateral sclerosis patients.
Journal of neurochemistry 2011;117(1):91-9.
2011: Anna Wuolikainen; Thomas Moritz; Stefan L Marklund; Henrik Antti; Peter M Andersen
Disease-related changes in the cerebrospinal fluid metabolome in amyotrophic lateral sclerosis detected by GC/TOFMS.
PloS one 2011;6(4):e17947.
2010: Anna Birve; Christoph Neuwirth; Markus Weber; Stefan L Marklund; Ann-Charloth Nilsson; Per Andreas Jonsson; Peter M Andersen
A novel SOD1 splice site mutation associated with familial ALS revealed by SOD activity analysis.
Human molecular genetics 2010;19(21):4201-6.
2010: Daniel Bergemalm; Karin Forsberg; Vaibhav Srivastava; Karin S Graffmo; Peter M Andersen; Thomas Brännström; Gunnar Wingsle; Stefan L Marklund
Superoxide dismutase-1 and other proteins in inclusions from transgenic amyotrophic lateral sclerosis model mice.
Journal of neurochemistry 2010;114(2):408-18.
2010: Kim Ekblom; Stefan L Marklund; Lars Johansson; Pia Osterman; Göran Hallmans; Lars Weinehall; Per-Gunnar Wiklund; Johan Hultdin
Bilirubin and UGT1A1*28 are not associated with lower risk for ischemic stroke in a prospective nested case-referent setting.
Cerebrovascular diseases (Basel, Switzerland) 2010;30(6):590-6.
2010: Karin Forsberg; P Andreas Jonsson; Peter M Andersen; Daniel Bergemalm; Karin S Graffmo; Magnus Hultdin; Johan Jacobsson; Roland Rosquist; Stefan L Marklund; Thomas Brännström
Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients.
PloS one 2010;5(7):e11552.
2009: P Andreas Jonsson; Karin S Graffmo; Peter M Andersen; Stefan L Marklund; Thomas Brännström
Superoxide dismutase in amyotrophic lateral sclerosis patients homozygous for the D90A mutation.
Neurobiology of disease 2009;36(3):421-4.
2009: Anna Wuolikainen; Mattias Hedenström; Thomas Moritz; Stefan L Marklund; Henrik Antti; Peter M Andersen
Optimization of procedures for collecting and storing of CSF for studying the metabolome in ALS.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2009;10(4):229-36.
2009: Daniel Bergemalm; Karin Forsberg; P Andreas Jonsson; Karin S Graffmo; Thomas Brännström; Peter M Andersen; Henrik Antti; Stefan L Marklund
Changes in the spinal cord proteome of an amyotrophic lateral sclerosis murine model determined by differential in-gel electrophoresis.
Molecular & cellular proteomics : MCP 2009;8(6):1306-17.
2009: Eva M Olofsson; Stefan L Marklund; Anders Behndig
Enhanced diabetes-induced cataract in copper-zinc superoxide dismutase-null mice.
Investigative ophthalmology & visual science 2009;50(6):2913-8.
2009: Svetlana V Antonyuk; Richard W Strange; Stefan L Marklund; S Samar Hasnain
The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding.
Journal of molecular biology 2009;388(2):310-26.
2008: P Andreas Jonsson; Daniel Bergemalm; Peter M Andersen; Ole Gredal; Thomas Brännström; Stefan L Marklund
Inclusions of amyotrophic lateral sclerosis-linked superoxide dismutase in ventral horns, liver, and kidney.
Annals of neurology 2008;63(5):671-5.
2008: Stephen J Bruce; Pär Jonsson; Henrik Antti; Olivier Cloarec; Johan Trygg; Stefan L Marklund; Thomas Moritz
Evaluation of a protocol for metabolic profiling studies on human blood plasma by combined ultra-performance liquid chromatography/mass spectrometry: From extraction to data analysis.
Analytical biochemistry 2008;372(2):237-49.
2007: Per Zetterström; Heather G Stewart; Daniel Bergemalm; P Andreas Jonsson; Karin S Graffmo; Peter M Andersen; Thomas Brännström; Mikael Oliveberg; Stefan L Marklund
Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14157-62.
2007: Claus G Krenn; Göran Hedenstierna; Samar Basu; Stefan L Marklund; Josephine Hjoberg
Maintaining nitric oxide-induced airway relaxation with superoxide dismutase.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2007;16(4):419-24.
2007: Eva M Olofsson; Stefan L Marklund; Anders Behndig
Glucose-induced cataract in CuZn-SOD null lenses: an effect of nitric oxide?
Free radical biology & medicine 2007;42(7):1098-105.
2007: Oliver Jung; Stefan L Marklund; Ning Xia; Rudi Busse; Ralf P Brandes
Inactivation of extracellular superoxide dismutase contributes to the development of high-volume hypertension.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(3):470-7.
2007: Andreas Hörnberg; Derek Logan; Stefan L Marklund; Mikael Oliveberg
The coupling between disulphide status, metallation and dimer interface strength in Cu/Zn superoxide dismutase.
Journal of molecular biology 2007;365(2):333-42.
2007: Kim Ekblom; Johan Hultdin; Birgitta Stegmayr; Ingegerd Johansson; Bethany Van Guelpen; Göran Hallmans; Lars Weinehall; Lars Johansson; Per-Gunnar Wiklund; Stefan L Marklund
Iron stores and HFE genotypes are not related to increased risk of ischemic stroke. A prospective nested case-referent study.
Cerebrovascular diseases (Basel, Switzerland) 2007;24(5):405-11.
2007: Eva M Olofsson; Stefan L Marklund; Fatima Pedrosa-Domellöf; Anders Behndig
Interleukin-1alpha downregulates extracellular-superoxide dismutase in human corneal keratoconus stromal cells.
Molecular vision 2007;13():1285-90.
2007: Anna Möllsten; Stefan L Marklund; Maija Wessman; Maria Svensson; Carol Forsblom; Maija Parkkonen; Kerstin Brismar; Per-Henrik Groop; Gisela Dahlquist
A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy.
Diabetes 2007;56(1):265-9.
2006: P Andreas Jonsson; Karin S Graffmo; Thomas Brännström; Peter Nilsson; Peter M Andersen; Stefan L Marklund
Motor neuron disease in mice expressing the wild type-like D90A mutant superoxide dismutase-1.
Journal of neuropathology and experimental neurology 2006;65(12):1126-36.
2006: Heather G Stewart; I R Mackenzie; Andrew Eisen; Thomas Brännström; Stefan L Marklund; Peter M Andersen
Clinicopathological phenotype of ALS with a novel G72C SOD1 gene mutation mimicking a myopathy.
Muscle & nerve 2006;33(5):701-6.
2006: Daniel Bergemalm; P Andreas Jonsson; Karin S Graffmo; Peter M Andersen; Thomas Brännström; Anna Rehnmark; Stefan L Marklund
Overloading of stable and exclusion of unstable human superoxide dismutase-1 variants in mitochondria of murine amyotrophic lateral sclerosis models.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(16):4147-54.
2006: Marie-Louise Sentman; Micael Granström; Håkan Jakobson; Andrew Reaume; Samar Basu; Stefan L Marklund
Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase.
The Journal of biological chemistry 2006;281(11):6904-9.
2006: P Andreas Jonsson; Karin S Graffmo; Peter M Andersen; Thomas Brännström; Mikael Lindberg; Mikael Oliveberg; Stefan L Marklund
Disulphide-reduced superoxide dismutase-1 in CNS of transgenic amyotrophic lateral sclerosis models.
Brain : a journal of neurology 2006;129(Pt 2):451-64.
2005: Jiye A; Johan Trygg; Jonas Gullberg; Annika I Johansson; Pär Jonsson; Henrik Antti; Stefan L Marklund; Thomas Moritz
Extraction and GC/MS analysis of the human blood plasma metabolome.
Analytical chemistry 2005;77(24):8086-94.
2005: Eva M Olofsson; Stefan L Marklund; Kurt Karlsson; Thomas Brännström; Anders Behndig
In vitro glucose-induced cataract in copper-zinc superoxide dismutase null mice.
Experimental eye research 2005;81(6):639-46.
2005: Lillemor Mattsson Hultén; Christina Ullström; Alexandra Krettek; David van Reyk; Stefan L Marklund; Claes Dahlgren; Olov Wiklund
Human macrophages limit oxidation products in low density lipoprotein.
Lipids in health and disease 2005;4():6.
2004: Olov Rolandsson; Stefan L Marklund; Margareta Norberg; Asa Agren; Erik Hägg
Hemoglobin A1c can be analyzed in blood kept frozen at -80 degrees C and is not commonly affected by hemolysis in the general population.
Metabolism: clinical and experimental 2004;53(11):1496-9.
2004: P Andreas Jonsson; Karin Ernhill; Peter M Andersen; Daniel Bergemalm; Thomas Brännström; Ole Gredal; Peter Nilsson; Stefan L Marklund
Minute quantities of misfolded mutant superoxide dismutase-1 cause amyotrophic lateral sclerosis.
Brain : a journal of neurology 2004;127(Pt 1):73-88.
2003: Oliver Jung; Stefan L Marklund; Helmut Geiger; Thierry Pedrazzini; Rudi Busse; Ralf P Brandes
Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice.
Circulation research 2003;93(7):622-9.
2003: Laurens Kruidenier; Ineke Kuiper; Wim van Duijn; Stefan L Marklund; Ruud A van Hogezand; Cornelis B H W Lamers; Hein Verspaget
Differential mucosal expression of three superoxide dismutase isoforms in inflammatory bowel disease.
The Journal of pathology 2003;201(1):7-16.
2003: Pontus Strålin; Håkan Jacobsson; Stefan L Marklund
Oxidative stress, NO* and smooth muscle cell extracellular superoxide dismutase expression.
Biochimica et biophysica acta 2003;1619(1):1-8.
2002: Ascan Warnholtz; Hanke Mollnau; Thomas Heitzer; Anatol Kontush; Tobias Möller-Bertram; Dirk Lavall; Adel Giaid; Ulrike Beisiegel; Stefan L Marklund; Ulrich Walter; Thomas Meinertz; Thomas Munzel
Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits.
Journal of the American College of Cardiology 2002;40(7):1356-63.
2002: P Andreas Jonsson; Asa Bäckstrand; Peter M Andersen; Johan Jacobsson; Matthew J Parton; Chris Shaw; Robert Swingler; Pamela J Shaw; Wim Robberecht; Albert C Ludolph; Teepu Siddique; Veronica I Skvortsova; Stefan L Marklund
CuZn-superoxide dismutase in D90A heterozygotes from recessive and dominant ALS pedigrees.
Neurobiology of disease 2002;10(3):327-33.
2002: Lena M Jonsson; Daryl D Rees; Thomas Edlund; Stefan L Marklund
Nitric oxide and blood pressure in mice lacking extracellular-superoxide dismutase.
Free radical research 2002;36(7):755-8.
2002: Jan Sandström; Lena M Jonsson; Ulla Edlund; Dan Holmberg; Stefan L Marklund
Overexpression of extracellular-SOD in islets of nonobese diabetic mice and development of diabetes.
Free radical biology & medicine 2002;33(1):71-5.
2002: Marie-Louise Sentman; Thomas Brännström; Stefan L Marklund
EC-SOD and the response to inflammatory reactions and aging in mouse lung.
Free radical biology & medicine 2002;32(10):975-81.
2002: Lena M Jonsson; Thomas Edlund; Stefan L Marklund; Thomas Sandström
Increased ozone-induced airway neutrophilic inflammation in extracellular-superoxide dismutase null mice.
Respiratory medicine 2002;96(4):209-14.
2002: Tiina M Tikka; Nina Vartiainen; Gundars Goldsteins; Simo S Oja; Peter M Andersen; Stefan L Marklund; Jari Koistinaho
Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease.
Brain : a journal of neurology 2002;125(Pt 4):722-31.
2002: Stefan L Marklund
Extracellular superoxide dismutase.
Methods in enzymology 2002;349():74-80.
2001: Anders Behndig; Kurt Karlsson; Thomas Brännström; Marie-Louise Sentman; Stefan L Marklund
Corneal endothelial integrity in mice lacking extracellular superoxide dismutase.
Investigative ophthalmology & visual science 2001;42(12):2784-8.
2001: Pontus Strålin; Stefan L Marklund
Vasoactive factors and growth factors alter vascular smooth muscle cell EC-SOD expression.
American journal of physiology. Heart and circulatory physiology 2001;281(4):H1621-9.
2001: Anders Behndig; Kurt Karlsson; A G Reaume; Marie-Louise Sentman; Stefan L Marklund
In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase.
Free radical biology & medicine 2001;31(6):738-44.
2001: Marie-Louise Sentman; Thomas Brännström; S Westerlund; Mikko O Laukkanen; Seppo Ylä-Herttuala; Samar Basu; Stefan L Marklund
Extracellular superoxide dismutase deficiency and atherosclerosis in mice.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(9):1477-82.
2001: Anders Behndig; Kurt Karlsson; B O Johansson; Thomas Brännström; Stefan L Marklund
Superoxide dismutase isoenzymes in the normal and diseased human cornea.
Investigative ophthalmology & visual science 2001;42(10):2293-6.
2001: Johan Jacobsson; P Andreas Jonsson; Peter M Andersen; Lars Forsgren; Stefan L Marklund
Superoxide dismutase in CSF from amyotrophic lateral sclerosis patients with and without CuZn-superoxide dismutase mutations.
Brain : a journal of neurology 2001;124(Pt 7):1461-6.
2000: Mikko O Laukkanen; Pauliina Lehtolainen; Päivi Turunen; S Aittomäki; P Oikari; Stefan L Marklund; Seppo Ylä-Herttuala
Rabbit extracellular superoxide dismutase: expression and effect on LDL oxidation.
Gene 2000;254(1-2):173-9.
2000: Pontus Strålin; Stefan L Marklund
Multiple cytokines regulate the expression of extracellular superoxide dismutase in human vascular smooth muscle cells.
Atherosclerosis 2000;151(2):433-41.
1999: Björn Tyrberg; Decio L Eizirik; Stefan L Marklund; BT Olejnicka; O D Madsen; Arne Andersson
Human islets in mixed islet grafts protect mouse pancreatic beta-cells from alloxan toxicity.
Pharmacology & toxicology 1999;85(6):269-75.
1999: Marie-Louise Sentman; Lena M Jonsson; Stefan L Marklund
Enhanced alloxan-induced beta-cell damage and delayed recovery from hyperglycemia in mice lacking extracellular-superoxide dismutase.
Free radical biology & medicine 1999;27(7-8):790-6.
1998: Anders Behndig; B Svensson; Stefan L Marklund; Kurt Karlsson
Superoxide dismutase isoenzymes in the human eye.
Investigative ophthalmology & visual science 1998;39(3):471-5.
1998: Jukka S Luoma; Pontus Strålin; Stefan L Marklund; TP Hiltunen; Terttu Särkioja; Seppo Ylä-Herttuala
Expression of extracellular SOD and iNOS in macrophages and smooth muscle cells in human and rabbit atherosclerotic lesions: colocalization with epitopes characteristic of oxidized LDL and peroxynitrite-modified proteins.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(2):157-67.
1998: Peter M Andersen; P Nilsson; Lars Forsgren; Stefan L Marklund
CuZn-superoxide dismutase, extracellular superoxide dismutase, and glutathione peroxidase in blood from individuals homozygous for Asp90Ala CuZu-superoxide dismutase mutation.
Journal of neurochemistry 1998;70(2):715-20.
1997: Peter M Andersen; P Nilsson; M L Keränen; Lars Forsgren; J Hägglund; Merete Karlsborg; LO Ronnevi; Ole Gredal; Stefan L Marklund
Phenotypic heterogeneity in motor neuron disease patients with CuZn-superoxide dismutase mutations in Scandinavia.
Brain : a journal of neurology 1997;120 ( Pt 10)():1723-37.
1997: Stefan L Marklund; Peter M Andersen; Lars Forsgren; P Nilsson; P I Ohlsson; G Wikander; A Oberg
Normal binding and reactivity of copper in mutant superoxide dismutase isolated from amyotrophic lateral sclerosis patients.
Journal of neurochemistry 1997;69(2):675-81.
1996: Peter M Andersen; L Forsgren; Michael Binzer; P Nilsson; V Ala-Hurula; M L Keränen; L Bergmark; A Saarinen; T Haltia; I Tarvainen; E Kinnunen; B Udd; Stefan L Marklund
Autosomal recessive adult-onset amyotrophic lateral sclerosis associated with homozygosity for Asp90Ala CuZn-superoxide dismutase mutation. A clinical and genealogical study of 36 patients.
Brain : a journal of neurology 1996;119 ( Pt 4)():1153-72.
1995: Peter M Andersen; P Nilsson; V Ala-Hurula; M L Keränen; I Tarvainen; T Haltia; L Nilsson; Michael Binzer; L Forsgren; Stefan L Marklund
Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase.
Nature genetics 1995;10(1):61-6.