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Gerald Marks

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Chemicals & Drugs

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H Ahmed; Brian E McLaughlin; Jonathan M Soong; Gerald S Marks; James F Brien; Kanji Nakatsu
The source of endogenous carbon monoxide formation in human placental chorionic villi.
Kinga Jaronczyk; Loc Bui; Jonathan M Soong; Brian E McLaughlin; Gerald S Marks; James F Brien; Kanji Nakatsu
The source of heme for vascular heme oxygenase II: de novo heme biosynthesis in rat aorta.
Loc Bui; Kimberly Rish; Kinga Jaronczyk; Stephane Bourque; Brian E McLaughlin; James F Brien; Gerald S Marks; Ann Smith; Kanji Nakatsu
The source of heme for vascular heme oxygenase I: heme uptake in rat aorta.

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2005: H Ahmed; Brian E McLaughlin; Jonathan M Soong; Gerald S Marks; James F Brien; Kanji Nakatsu
The source of endogenous carbon monoxide formation in human placental chorionic villi.
Cellular and molecular biology (Noisy-le-Grand, France) 2005;51(5):447-51.
2004: Kinga Jaronczyk; Loc Bui; Jonathan M Soong; Brian E McLaughlin; Gerald S Marks; James F Brien; Kanji Nakatsu
The source of heme for vascular heme oxygenase II: de novo heme biosynthesis in rat aorta.
Canadian journal of physiology and pharmacology 2004;82(4):218-24.
2004: Loc Bui; Kimberly Rish; Kinga Jaronczyk; Stephane Bourque; Brian E McLaughlin; James F Brien; Gerald S Marks; Ann Smith; Kanji Nakatsu
The source of heme for vascular heme oxygenase I: heme uptake in rat aorta.
Canadian journal of physiology and pharmacology 2004;82(4):209-17.
2003: Scott D Appleton; Gendie Lash; Gerald S Marks; Kanji Nakatsu; James F Brien; Graeme N Smith; Charles H Graham
Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;285(6):R1453-60.
2003: Gerald S Marks; J F Brien; Kanji Nakatsu
What role does the heme-- heme oxygenase--carbon monoxide system play in vasoregulation?
American journal of physiology. Regulatory, integrative and comparative physiology 2003;285(3):R522-3.
2003: Brian E McLaughlin; Gendie Lash; Graeme N Smith; Gerald S Marks; Kanji Nakatsu; Charles H Graham; James F Brien
Heme oxygenase expression in selected regions of term human placenta.
Experimental biology and medicine (Maywood, N.J.) 2003;228(5):564-7.
2003: Scott D Appleton; Gerald S Marks; Kanji Nakatsu; James F Brien; Graeme N Smith; Charles H Graham; Gendie Lash
Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells.
American journal of physiology. Heart and circulatory physiology 2003;284(3):H853-8.
2003: Jeremy T Gamble; Kanji Nakatsu; Gerald S Marks
Comparison of the formation of N-alkylprotoporphyrin IX after interaction of porphyrinogenic xenobiotics with single cDNA-expressed human P450 enzymes in microsomes prepared from baculovirus-infected insect cells and human lymphoblastoid cell lines.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(2):202-5.
2003: Gendie Lash; Brian E McLaughlin; Shannyn K Macdonald-Goodfellow; Graeme N Smith; James F Brien; Gerald S Marks; Kanji Nakatsu; Charles H Graham
Relationship between tissue damage and heme oxygenase expression in chorionic villi of term human placenta.
American journal of physiology. Heart and circulatory physiology 2003;284(1):H160-7.
2002: Jeremy T Gamble; Kanji Nakatsu; Gerald S Marks
Comparison of rat and human cytochrome P450 (CYP) sources of N-alkylprotoporphyrin IX. Formation after interaction with porphyrinogenic xenobiotics: studies with cDNA-expressed single CYP enzymes.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(11):997-1006.
2002: Shannon A Bainbridge; Anne E Farley; Brian E McLaughlin; Charles H Graham; Gerald S Marks; Kanji Nakatsu; James F Brien; Graeme N Smith
Carbon monoxide decreases perfusion pressure in isolated human placenta.
Placenta 2002;23(8-9):563-9.
2002: S Hosein; Gerald S Marks; James F Brien; Brian E McLaughlin; Kanji Nakatsu
An extracellular source of heme can induce a significant heme oxygenase mediated relaxation in the rat aorta.
Canadian journal of physiology and pharmacology 2002;80(8):761-5.
2002: James A Lavigne; Kanji Nakatsu; Gerald S Marks
Identification of human hepatic cytochrome P450 sources of N-alkylprotoporphyrin IX after interaction with porphyrinogenic xenobiotics, implications for detection of xenobiotic-induced porphyria in humans.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(7):788-94.
2002: Scott D Appleton; Gerald S Marks; Kanji Nakatsu; James F Brien; Graeme N Smith; Charles H Graham
Heme oxygenase activity in placenta: direct dependence on oxygen availability.
American journal of physiology. Heart and circulatory physiology 2002;282(6):H2055-9.
2002: Gerald S Marks; Hendrik J Vreman; Brian E McLaughlin; James F Brien; Kanji Nakatsu
Measurement of endogenous carbon monoxide formation in biological systems.
Antioxidants & redox signaling 2002;4(2):271-7.
2002: Jeremy T Gamble; Kanji Nakatsu; Gerald S Marks
Porphyrinogenic xenobiotic-induced N-alkylprotoporphyrin IX formation: a bioassay utilizing chick embryo hepatic ferrochelatase.
Journal of pharmacological and toxicological methods 2002;47(1):25-32.
2001: Brian E McLaughlin; Gendie Lash; Charles H Graham; Graeme N Smith; Hendrik J Vreman; David K Stevenson; Gerald S Marks; Kanji Nakatsu; James F Brien
Endogenous carbon monoxide formation by chorionic villi of term human placenta.
Placenta 2001;22(10):886-8.
2001: Susan M Kobus; SG Wong; Gerald S Marks
Isolation of regioisomers of N-alkylprotoporphyrin IX from chick embryo liver after treatment with porphyrinogenic xenobiotics.
Canadian journal of physiology and pharmacology 2001;79(9):814-21.
2001: D A O'Reilly; Brian E McLaughlin; Gerald S Marks; James F Brien; Kanji Nakatsu
YC-1 enhances the responsiveness of tolerant vascular smooth muscle to glyceryl trinitrate.
Canadian journal of physiology and pharmacology 2001;79(1):43-8.
2000: Brian E McLaughlin; J M Hutchinson; Charles H Graham; Graeme N Smith; Gerald S Marks; Kanji Nakatsu; James F Brien
Heme oxygenase activity in term human placenta.
Placenta 2000;21(8):870-3.
2000: Jeremy T Gamble; SG Wong; Harry A. Dailey; Gerald S Marks
Use of recombinant human ferrochelatase as a sensitive bioassay for N-alkylprotoporphyrin IX formed after interaction of porphyrinogenic xenobiotics with rat liver microsomes.
Canadian journal of physiology and pharmacology 2000;78(7):578-81.
2000: Hendrik J Vreman; Ronald J Wong; E C Kim; D C Nabseth; Gerald S Marks; David K Stevenson
Haem oxygenase activity in human umbilical cord and rat vascular tissues.
Placenta 2000;21(4):337-44.
2000: Brian E McLaughlin; M L Chretien; C Choi; James F Brien; Kanji Nakatsu; Gerald S Marks
Potentiation of carbon monoxide-induced relaxation of rat aorta by YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole].
Canadian journal of physiology and pharmacology 2000;78(4):343-9.
2000: Jeremy T Gamble; Harry A. Dailey; Gerald S Marks
N-Methylprotoporphyrin is a more potent inhibitor of recombinant human than of recombinant chicken ferrochelatase.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(4):373-5.
1999: SG Wong; Gerald S Marks
Formation of N-alkylprotoporphyrin IX after interaction of porphyrinogenic xenobiotics with rat liver microsomes.
Journal of pharmacological and toxicological methods 1999;42(3):107-13.
1999: Scott D Appleton; M L Chretien; Brian E McLaughlin; Hendrik J Vreman; David K Stevenson; James F Brien; Kanji Nakatsu; Donald H Maurice; Gerald S Marks
Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(10):1214-9.
1999: SG Wong; E H Lin; Gerald S Marks
Cytochrome CYP sources of N-alkylprotoporphyrin IX after administration of porphyrinogenic xenobiotics to rats.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(9):960-5.
1999: AS Hussain; N H Crispino; Brian E McLaughlin; James F Brien; Gerald S Marks; Kanji Nakatsu
Glyceryl trinitrate-induced vasodilation is inhibited by ultraviolet irradiation despite enhanced nitric oxide generation: evidence for formation of a nitric oxide conjugate.
The Journal of pharmacology and experimental therapeutics 1999;289(2):895-900.
1998: M J Odrcich; Charles H Graham; K A Kimura; Brian E McLaughlin; Gerald S Marks; Kanji Nakatsu; James F Brien
Heme oxygenase and nitric oxide synthase in the placenta of the guinea-pig during gestation.
Placenta 1998;19(7):509-16.
1998: SG Wong; Susan M Kobus; J P McNamee; Gerald S Marks
Gender differences in N-alkyl protoporphyrin IX production in rats after the administration of porphyrinogenic xenobiotics.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(8):739-44.
1998: D V Vukomanovic; A Hussain; Dick E Zoutman; Gerald S Marks; James F Brien; Kanji Nakatsu
Analysis of nanomolar S-nitrosothiol concentrations in physiological media.
Journal of pharmacological and toxicological methods 1998;39(4):235-40.
1998: M F Kearney; James F Brien; Gerald S Marks; H Lei; Kanji Nakatsu
Thiol agents separate nitric oxide formation from vasodilation induced by glyceryl trinitrate.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(6):547-51.
1997: AS Hussain; Gerald S Marks; James F Brien; Kanji Nakatsu
The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate.
Canadian journal of physiology and pharmacology 1997;75(8):1034-7.
1997: M N Cook; Gerald S Marks; Hendrik J Vreman; Brian E McLaughlin; Kanji Nakatsu; David K Stevenson; James F Brien
Carbon monoxide formation in the guinea pig hippocampus: ontogeny and effect of in vitro ethanol exposure.
Brain research. Developmental brain research 1997;101(1-2):283-6.
1997: AS Hussain; T N Abu-Zahra; James F Brien; Gerald S Marks; Kanji Nakatsu
Thiol agents potentiate glyceryl trinitrate mediated relaxation of rabbit taenia coli: evidence for thiol-dependent biotransformation.
Canadian journal of physiology and pharmacology 1997;75(7):807-11.
1997: Gerald S Marks; Brian E McLaughlin; Hendrik J Vreman; David K Stevenson; Kanji Nakatsu; James F Brien; Stephen C Pang
Heme oxygenase activity and immunohistochemical localization in bovine pulmonary artery and vein.
Journal of cardiovascular pharmacology 1997;30(1):1-6.
1997: AS Hussain; J Bozinovski; Donald H Maurice; Brian E McLaughlin; Gerald S Marks; James F Brien; Kanji Nakatsu
Inhibition of the action of nitric oxide prodrugs by pyocyanin: mechanistic studies.
Canadian journal of physiology and pharmacology 1997;75(5):398-406.
1997: J P McNamee; M Jurima-Romet; Susan M Kobus; Gerald S Marks
cDNA-expressed human cytochrome P450 isozymes. Inactivation by porphyrinogenic xenobiotics.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(4):437-41.
1997: M N Cook; Gerald S Marks; Hendrik J Vreman; Kanji Nakatsu; David K Stevenson; James F Brien
Heme oxygenase activity and acute and chronic ethanol exposure in the hippocampus, frontal cerebral cortex, and cerebellum of the near-term fetal guinea pig.
Alcohol (Fayetteville, N.Y.) 1997;14(2):117-24.
1997: D V Vukomanovic; Dick E Zoutman; J A Stone; Gerald S Marks; James F Brien; Kanji Nakatsu
Electrospray mass-spectrometric, spectrophotometric and electrochemical methods do not provide evidence for the binding of nitric oxide by pyocyanine at pH 7.
The Biochemical journal 1997;322 ( Pt 1)():25-9.
1997: Flavio Coceani; Lois Kelsey; Eric Seidlitz; Gerald S Marks; Brian E McLaughlin; Hendrik J Vreman; David K Stevenson; Marlene Rabinovitch; Cameron Ackerley
Carbon monoxide formation in the ductus arteriosus in the lamb: implications for the regulation of muscle tone.
British journal of pharmacology 1997;120(4):599-608.
1996: D V Vukomanovic; Dick E Zoutman; Gerald S Marks; James F Brien; G W van Loon; Kanji Nakatsu
Analysis of pyocyanin from Pseudomonas aeruginosa by adsorptive stripping voltammetry.
Journal of pharmacological and toxicological methods 1996;36(2):97-102.
1996: J P McNamee; Susan M Kobus; Gerald S Marks
The apoprotein of cytochrome P450 3A2 does not selectively direct alkylation to one of four pyrrole rings of N-vinylprotoporphyrin IX.
Canadian journal of physiology and pharmacology 1996;74(8):996-1000.
1996: J P McNamee; Gerald S Marks
Cytochrome P4503A is the major source of N-vinylprotoporphyrin IX formation after administration of 3-[2-(2,4,6-trimethylphenyl)thioethyl]-4-methylsydnone to untreated and dexamethasone-pretreated rats.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(8):872-8.
1996: AS Hussain; James F Brien; Gerald S Marks; Kanji Nakatsu
Superoxide does not inhibit glyceryl trinitrate-rabbit aortic strip-mediated relaxation of rabbit Taenia coli. Evidence against a role for nitric oxide itself as the smooth muscle active drug metabolite?
Drug metabolism and disposition: the biological fate of chemicals 1996;24(7):780-5.
1996: S M Kimmett; R A Whitney; Gerald S Marks
Isolation of N-vinylprotoporphyrin IX after hepatic cytochrome P450 inactivation by 3-[(arylthio)ethyl]sydnone in chick embryos pretreated with phenobarbital, glutethimide, dexamethasone, and beta-naphthoflavone: differential inhibition of ferrochelatase by N-vinylprotoporphyrin regioisomers.
Molecular pharmacology 1996;49(4):676-82.
1996: M N Cook; Gerald S Marks; Hendrik J Vreman; Kanji Nakatsu; David K Stevenson; James F Brien
Ontogeny of heme oxygenase activity in the hippocampus, frontal cerebral cortex, and cerebellum of the guinea pig.
Brain research. Developmental brain research 1996;92(1):18-23.
1996: S M Kimmett; J P McNamee; Gerald S Marks
Chick embryo liver microsomal steroid hydroxylations: induction by dexamethasone, phenobarbital, and glutethimide and inactivation following the in ovo administration of porphyrinogenic compounds.
Canadian journal of physiology and pharmacology 1996;74(1):97-103.
1996: James F Brien; Brian E McLaughlin; Kanji Nakatsu; Gerald S Marks
Chemiluminescence headspace-gas analysis for determination of nitric oxide formation in biological systems.
Methods in enzymology 1996;268():83-92.
1995: Gerald S Marks; Brian E McLaughlin; S L Jimmo; M Poklewska-Koziell; James F Brien; Kanji Nakatsu
Time-dependent increase in nitric oxide formation concurrent with vasodilation induced by sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-N-acetylpenicillamine but not by glyceryl trinitrate.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(11):1248-52.
1995: Z G Liu; Brian E McLaughlin; Gerald S Marks; James F Brien; Kanji Nakatsu
Sulfhydryl involvement in nitric oxide sequestration and nitric oxide induced guanylyl cyclase activation in vascular smooth muscle.
Canadian journal of physiology and pharmacology 1995;73(8):1144-8.
1995: J P McNamee; S M Kimmett; Gerald S Marks
Inactivation of chick embryo hepatic cytochrome P450 1A, 2H and 3A following in ovo administration of 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-ethylpyridine and 3-[2-(2,4,6-trimethylphenyl)thioethyl]-4-methylsydnone.
Biochemical pharmacology 1995;49(10):1443-52.
1995: M N Cook; Kanji Nakatsu; Gerald S Marks; Brian E McLaughlin; Hendrik J Vreman; David K Stevenson; James F Brien
Heme oxygenase activity in the adult rat aorta and liver as measured by carbon monoxide formation.
Canadian journal of physiology and pharmacology 1995;73(4):515-8.
1994: AS Hussain; M Poklewska-Koziell; James F Brien; Gerald S Marks; Kanji Nakatsu
Nitric oxide formation from glyceryl trinitrate by rabbit aortic strip: detection by rabbit taenia coli concurrent with vasorelaxation.
British journal of pharmacology 1994;113(4):1508-14.
1994: Gerald S Marks
Heme oxygenase: the physiological role of one of its metabolites, carbon monoxide and interactions with zinc protoporphyrin, cobalt protoporphyrin and other metalloporphyrins.
Cellular and molecular biology (Noisy-le-Grand, France) 1994;40(7):863-70.
1994: Gerald S Marks
The history of pharmacology in Canada.
Trends in pharmacological sciences 1994;15(7):205-10.
1994: J Bozinovski; James F Brien; Gerald S Marks; Kanji Nakatsu
Inhibition of nitrovasodilators by pyocyanin and methylene blue is dissociated from nitric oxide formation.
Canadian journal of physiology and pharmacology 1994;72(7):746-52.
1994: S M Kimmett; J P McNamee; R T Denofreo; Gerald S Marks
Evidence for mechanism-based inactivation of rat and chick embryo hepatic cytochrome P4501A and P4503A by dihydropyridines, sydnones, and dihydroquinolines.
Biochemical pharmacology 1994;47(11):2069-78.
1994: B P Booth; James F Brien; Gerald S Marks; Brian Milne; F Cervenko; J Pym; J Knight; K Rogers; Tomas A Salerno; Kanji Nakatsu
The effects of hypothermic and normothermic cardiopulmonary bypass on glyceryl trinitrate activity.
Anesthesia and analgesia 1994;78(5):848-56.
1994: S M Kimmett; J P McNamee; Gerald S Marks
Mechanism-based inactivation of hepatic cytochrome P450 2C6 and P450 3A1 following in vivo administration of 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-ethylpyridine to rats: differences from previously observed in vitro results.
Canadian journal of physiology and pharmacology 1994;72(4):397-401.
1994: T Horn; Pauline M Smith; Brian E McLaughlin; L Bauce; Gerald S Marks; Quentin J Pittman; Alastair V Ferguson
Nitric oxide actions in paraventricular nucleus: cardiovascular and neurochemical implications.
The American journal of physiology 1994;266(1 Pt 2):R306-13.
1993: E D Beaton; Z Liu; Brian E McLaughlin; James F Brien; Kanji Nakatsu; Gerald S Marks
A novel method for detection of nitric oxide binding sites by using a chemiluminescence-headspace gas technique.
Journal of pharmacological and toxicological methods 1993;30(4):217-22.
1993: Z Liu; Kanji Nakatsu; James F Brien; E D Beaton; Gerald S Marks; Donald H Maurice
Selective sequestration of nitric oxide by subcellular components of vascular smooth muscle and platelets: relationship to nitric oxide stimulation of the soluble guanylyl cyclase.
Canadian journal of physiology and pharmacology 1993;71(12):938-45.
1993: Gerald S Marks; Kanji Nakatsu; James F Brien
Does endogenous zinc protoporphyrin modulate carbon monoxide formation from heme? Implications for long-term potentiation, memory, and cognitive function.
Canadian journal of physiology and pharmacology 1993;71(10-11):753-4.
1993: B P Booth; James F Brien; Gerald S Marks; Kanji Nakatsu
Effect of temperature on glyceryl trinitrate induced relaxation of rabbit aorta.
Canadian journal of physiology and pharmacology 1993;71(8):629-32.
1993: Z Liu; James F Brien; Gerald S Marks; Brian E McLaughlin; Kanji Nakatsu
Lack of evidence for the involvement of cytochrome P-450 or other hemoproteins in metabolic activation of glyceryl trinitrate in rabbit aorta.
The Journal of pharmacology and experimental therapeutics 1993;264(3):1432-9.
1992: S M Kimmett; Gerald S Marks
Thin-layer chromatographic separation of the ferrochelatase-inhibitory ring A and ring B regioisomers of N-ethylprotoporphyrin from a mixture of the four regioisomers.
Journal of pharmacological and toxicological methods 1992;28(2):113-7.
1992: S M Kimmett; R A Whitney; Gerald S Marks
Evidence for the stereoselective inhibition of chick embryo hepatic ferrochelatase by N-alkylated porphyrins. II.
Molecular pharmacology 1992;42(2):307-10.
1992: S A McCluskey; D S Riddick; J E Mackie; S M Kimmett; R A Whitney; Gerald S Marks
Inactivation of cytochrome P450 and inhibition of ferrochelatase by analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine with 4-nonyl and 4-dodecyl substituents.
Canadian journal of physiology and pharmacology 1992;70(8):1069-74.
1992: Kanji Nakatsu; James F Brien; G Savard; Edwin B Toffelmire; Hoshiar Abdollah; Brian M Bennett; Gerald S Marks
Plasma disposition and hemodynamic effects of a single oral dose of isosorbide dinitrate in human males and females.
Biopharmaceutics & drug disposition 1992;13(5):357-67.
1992: R P Green-Thompson; S M Kimmett; Gerald S Marks
Inhibition of chick embryo hepatic uroporphyrinogen decarboxylase by components of xenobiotic-treated chick embryo hepatocytes in culture. II.
Canadian journal of physiology and pharmacology 1992;70(7):939-42.
1992: Gerald S Marks; Brian E McLaughlin; Kanji Nakatsu; James F Brien
Biotransformation of glyceryl trinitrate by rat brain homogenate.
Canadian journal of physiology and pharmacology 1992;70(6):935-7.
1992: Gerald S Marks; Brian E McLaughlin; Kanji Nakatsu; James F Brien
Direct evidence for nitric oxide formation from glyceryl trinitrate during incubation with intact bovine pulmonary artery.
Canadian journal of physiology and pharmacology 1992;70(2):308-11.
1992: Z Liu; James F Brien; Gerald S Marks; Brian E McLaughlin; Kanji Nakatsu
Carbon monoxide does not inhibit glyceryl trinitrate biotransformation by or relaxation of aorta.
European journal of pharmacology 1992;211(1):129-32.
1991: J E Mackie; D W Back; J W Hamilton; Gerald S Marks
Elevation of delta-aminolevulinic acid synthase and cytochrome PB1 P450 messenger RNA levels by dihydropyridines, dihydroquinolines, sydnones, and N-ethylprotoporphyrin IX.
Biochemical pharmacology 1991;42(3):475-83.
1991: Gerald S Marks; Brian E McLaughlin; L B Brown; D E Beaton; B P Booth; Kanji Nakatsu; James F Brien
Interaction of glyceryl trinitrate and sodium nitroprusside with bovine pulmonary vein homogenate and 10,000 x g supernatant: biotransformation and nitric oxide formation.
Canadian journal of physiology and pharmacology 1991;69(6):889-92.
1991: Kanji Nakatsu; J Pym; S Witte; Gerald S Marks; James F Brien
Adrenoceptors of the human internal thoracic artery.
Canadian journal of physiology and pharmacology 1991;69(6):792-7.
1991: Gerald S Marks; James F Brien; Kanji Nakatsu; Brian E McLaughlin
Does carbon monoxide have a physiological function?
Trends in pharmacological sciences 1991;12(5):185-8.
1991: R P Green-Thompson; D S Riddick; J E Mackie; Gerald S Marks; James Halpert
Porphyrinogenic effects in chick embryo liver cell culture of chloramphenicol analogues that are mechanism-based inactivators of cytochrome P-450.
Canadian journal of physiology and pharmacology 1991;69(4):526-30.
1991: B P Booth; M Henderson; Brian Milne; F Cervenko; Gerald S Marks; James F Brien; Kanji Nakatsu
Sequestration of glyceryl trinitrate (nitroglycerin) by cardiopulmonary bypass oxygenators.
Anesthesia and analgesia 1991;72(4):493-7.
1991: James F Brien; Brian E McLaughlin; Kanji Nakatsu; Gerald S Marks
Quantitation of nitric oxide formation from nitrovasodilator drugs by chemiluminescence analysis of headspace gas.
Journal of pharmacological methods 1991;25(1):19-27.
1990: D S Riddick; I McGilvray; Gerald S Marks
Inactivation of rat liver microsomal steroid hydroxylations by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine: evidence for selectivity among steroid-inducible cytochrome P450IIIA forms.
Canadian journal of physiology and pharmacology 1990;68(12):1533-41.
1990: B P Booth; Brian M Bennett; James F Brien; D A Elliott; Gerald S Marks; J L McCans; Kanji Nakatsu
Assay of glyceryl trinitrate, isosorbide dinitrate, and their metabolites in plasma by large-bore capillary column gas-liquid chromatography.
Biopharmaceutics & drug disposition 1990;11(8):663-77.
1990: D S Riddick; Gerald S Marks
Irreversible binding of heme to microsomal protein during inactivation of cytochrome P450 by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine.
Biochemical pharmacology 1990;40(8):1915-21.
1990: J E Mackie; Paul R. Ortiz de Montellano; L A Grab; Gerald S Marks
Effects of 3-(2-phenylethyl)-4-methylsydnone and related sydnones on heme biosynthesis.
Biochemical pharmacology 1990;39(11):1767-74.
1990: J H Kawamoto; Brian E McLaughlin; James F Brien; Gerald S Marks; Kanji Nakatsu
Biotransformation of glyceryl trinitrate and elevation of cyclic GMP precede glyceryl trinitrate-induced vasodilation.
Journal of cardiovascular pharmacology 1990;15(5):714-9.
1990: D S Riddick; J E Mackie; Thomas E Massey; Gerald S Marks
3,5-Diethoxycarbonyl-2,6-dimethyl-4-ethyl-1,4-dihydropyridine inactivates rat liver cytochrome P-450c, but not its orthologue, rabbit lung form 6.
Canadian journal of physiology and pharmacology 1990;68(3):370-3.
1990: D S Riddick; S S Park; H V Gelboin; Gerald S Marks
Effects of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on hepatic cytochrome P-450 heme, apoproteins, and catalytic activities following in vivo administration to rats.
Molecular pharmacology 1990;37(1):130-6.
1989: C J Slack; Brian E McLaughlin; James F Brien; Gerald S Marks; Kanji Nakatsu
Biotransformation of glyceryl trinitrate and isosorbide dinitrate in vascular smooth muscle made tolerant to organic nitrates.
Canadian journal of physiology and pharmacology 1989;67(11):1381-5.
1989: S A McCluskey; R A Whitney; Gerald S Marks
Evidence for the stereoselective inhibition of chick embryo hepatic ferrochelatase by N-alkylated porphyrins.
Molecular pharmacology 1989;36(4):608-14.
1989: J E Mackie; Gerald S Marks
Synergistic induction of delta-aminolevulinic acid synthase activity by N-ethylprotoporphyrin IX and 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-isobutylpyridine .
Biochemical pharmacology 1989;38(13):2169-73.
1989: Gerald S Marks; S A McCluskey; J E Mackie; D S Riddick; C A James
Interaction of chemicals with cytochrome P-450: implications for the porphyrinogenicity of drugs.
Clinical biochemistry 1989;22(3):169-75.
1989: D S Riddick; S S Park; H V Gelboin; Gerald S Marks
Effects of a series of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on the major inducible cytochrome P-450 isozymes of rat liver.
Molecular pharmacology 1989;35(5):626-34.
1989: Gerald S Marks; Brian E McLaughlin; H F MacMillan; Kanji Nakatsu; James F Brien
Differential biotransformation of glyceryl trinitrate by red blood cell-supernatant fraction and pulmonary vein homogenate.
Canadian journal of physiology and pharmacology 1989;67(5):417-22.
1989: C A James; Gerald S Marks
Inhibition of chick embryo hepatic uroporphyrinogen decarboxylase by components of xenobiotic-treated chick embryo hepatocytes in culture.
Canadian journal of physiology and pharmacology 1989;67(3):246-9.
1989: Gerald S Marks; Kanji Nakatsu; B McLaughlin; J Kawamoto; C Slack; James F Brien
The role of nitric oxide formation in organic nitrate-induced vasodilation and organic nitrate tolerance.
Zeitschrift für Kardiologie 1989;78 Suppl 2():18-21; discussion 64-7.
1989: Gerald S Marks; J E Mackie; S A McCluskey; D S Riddick
Regulation of heme biosynthesis in chick embryo liver cells.
Advances in experimental medicine and biology 1989;271():123-33.
1988: C J Slack; Brian E McLaughlin; Kanji Nakatsu; Gerald S Marks; James F Brien
Nitric oxide-induced vasodilation of organic nitrate-tolerant rabbit aorta.
Canadian journal of physiology and pharmacology 1988;66(10):1344-6.
1988: Gerald S Marks; S A McCluskey; J E Mackie; D S Riddick; C A James
Disruption of hepatic heme biosynthesis after interaction of xenobiotics with cytochrome P-450.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(12):2774-83.
1988: S A McCluskey; Gerald S Marks; R A Whitney; Paul R. Ortiz de Montellano
Differential inhibition of hepatic ferrochelatase by regioisomers of N-butyl-, N-pentyl-, N-hexyl-, and N-isobutylprotoporphyrin IX.
Molecular pharmacology 1988;34(1):80-6.
1988: Kanji Nakatsu; J H Kawamoto; James F Brien; Gerald S Marks
A facile, reliable method for staining blood vessel endothelium.
Journal of pharmacological methods 1988;19(2):149-54.
1988: M E Lyon; J A Owen; Gerald S Marks
Xenobiotic mediated inhibition of hepatic uroporphyrinogen decarboxylase activity in 17-day-old chick embryo liver cells in culture.
Biochemical pharmacology 1988;37(6):1123-9.
1988: G S Tam; H MacMillan; Brian M Bennett; Gerald S Marks; James F Brien; Kanji Nakatsu
Patterns of isosorbide dinitrate and glyceryl trinitrate metabolites formed by selected segments of the rabbit gastrointestinal tract.
Canadian journal of physiology and pharmacology 1988;66(2):166-70.
1988: J H Kawamoto; James F Brien; Gerald S Marks; Kanji Nakatsu
Mechanism of glyceryl trinitrate-induced vasodilation. II. Lack of evidence for specific binding of GTN to bovine pulmonary vein.
The Journal of pharmacology and experimental therapeutics 1988;244(1):328-34.
1988: James F Brien; Brian E McLaughlin; Susan M Kobus; J H Kawamoto; Kanji Nakatsu; Gerald S Marks
Mechanism of glyceryl trinitrate-induced vasodilation. I. Relationship between drug biotransformation, tissue cyclic GMP elevation and relaxation of rabbit aorta.
The Journal of pharmacology and experimental therapeutics 1988;244(1):322-7.
1987: S A McCluskey; E P Sutherland; William J Racz; Gerald S Marks
Isolation of an N-alkylprotoporphyrin IX from chick embryo livers following the administration of 3,5-diethoxycarbonyl-1,4-dihydro-4-ethyl-2,6-dimethylpyridine.
Canadian journal of physiology and pharmacology 1987;65(7):1500-2.
1987: G S Tam; Gerald S Marks; James F Brien; Kanji Nakatsu
Sex- and species-related differences in the biotransformation of isosorbide dinitrate by various tissues of the rabbit and rat.
Canadian journal of physiology and pharmacology 1987;65(7):1478-83.
1987: J H Kawamoto; James F Brien; Gerald S Marks; Kanji Nakatsu
A comparative study of glyceryl trinitrate biotransformation and glyceryl trinitrate induced relaxation in bovine pulmonary artery and vein.
Canadian journal of physiology and pharmacology 1987;65(6):1146-50.
1987: G S Tam; Kanji Nakatsu; James F Brien; Gerald S Marks
Determination of isosorbide dinitrate biotransformation in various tissues of the rabbit by capillary column gas-liquid chromatography.
Biopharmaceutics & drug disposition 1987;8(1):37-45.
1987: Gerald S Marks; J Powles; M Lyon; S McCluskey; E Sutherland; D Zelt
Patterns of porphyrin accumulation in response to xenobiotics. Parallels between results in chick embryo and rodents.
Annals of the New York Academy of Sciences 1987;514():113-27.
1986: S A McCluskey; Gerald S Marks; E P Sutherland; N Jacobsen; Paul R. Ortiz de Montellano
Ferrochelatase-inhibitory activity and N-alkylprotoporphyrin formation with analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) containing extended 4-alkyl groups: implications for the active site of ferrochelatase.
Molecular pharmacology 1986;30(4):352-7.
1986: S A McCluskey; William J Racz; Gerald S Marks
Properties of 17- to 19-day-old chick embryo liver microsomes. Induction of cytochrome P-450, effect of storage at low temperature, and resistance to lipid peroxidation.
Journal of pharmacological methods 1986;16(2):111-23.
1986: Kanji Nakatsu; M Vandenberghe; Susan M Kobus; J Kawamoto; James F Brien; Gerald S Marks
Endothelium-dependent relaxation of rabbit aorta by acetylcholine requires ethylenediaminetetraacetic acid.
Canadian journal of physiology and pharmacology 1986;64(7):1050-2.
1986: B M Bennett; Susan M Kobus; James F Brien; Kanji Nakatsu; Gerald S Marks
Requirement for reduced, unliganded hemoprotein for the hemoglobin- and myoglobin-mediated biotransformation of glyceryl trinitrate.
The Journal of pharmacology and experimental therapeutics 1986;237(2):629-35.
1986: Gerald S Marks; D T Allen; E P Sutherland; S A McCluskey; R A Whitney
Comparison of the effects of 3-ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on ferrochelatase activity and heme biosynthesis in chick embryo liver cells in culture.
Canadian journal of physiology and pharmacology 1986;64(4):483-6.
1986: Gerald S Marks; D R Goldman; S A McCluskey; E P Sutherland; M E Lyon
The effects of dihydropyridine calcium antagonists on heme biosynthesis in chick embryo liver cell culture.
Canadian journal of physiology and pharmacology 1986;64(4):438-43.
1985: Gerald S Marks; D T Allen; C T Johnston; E P Sutherland; K Nakatsu; R A Whitney
Suicidal destruction of cytochrome P-450 and reduction of ferrochelatase activity by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells.
Molecular pharmacology 1985;27(4):459-65.
1984: Brian M Bennett; G S Tam; K Van Alstyne; James F Brien; Kanji Nakatsu; Gerald S Marks
Effect of 5-isosorbide mononitrate on isosorbide dinitrate-induced relaxation of rabbit aortic rings.
Canadian journal of physiology and pharmacology 1984;62(9):1194-7.
1981: SUSAN COLE; Thomas E Massey; Gerald S Marks; William J Racz
Effects of porphyrin-inducing drugs on ferrochelatase activity in isolated mouse hepatocytes.
Canadian journal of physiology and pharmacology 1981;59(11):1155-8.