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James Marks

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Yanfeng Zhang; Kathy L Jenko; Jianlong Lou; James D Marks; Susan M Varnum
Simultaneous and sensitive detection of six serotypes of botulinum neurotoxin using enzyme-linked immunosorbent assay-based protein antibody microarrays.
Q Meng; X Pan; M A Silberg; L Thorner; R To; M T Tomic; J Bettencourt; T Breece; F Conrad; C Garcia-Rodriguez; D Lee; M Li; G Manzanarez; James D Marks
Engineered domain-based assays to identify individual antibodies in oligoclonal combinations targeting the same protein.
Yu Zhou; Lequn Zhao; James D Marks
Selection and characterization of cell binding and internalizing phage antibodies.

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All Publications

2012: Yanfeng Zhang; Kathy L Jenko; Jianlong Lou; James D Marks; Susan M Varnum
Simultaneous and sensitive detection of six serotypes of botulinum neurotoxin using enzyme-linked immunosorbent assay-based protein antibody microarrays.
Analytical biochemistry 2012;430(2):185-92.
2012: Q Meng; X Pan; M A Silberg; L Thorner; R To; M T Tomic; J Bettencourt; T Breece; F Conrad; C Garcia-Rodriguez; D Lee; M Li; G Manzanarez; James D Marks
Engineered domain-based assays to identify individual antibodies in oligoclonal combinations targeting the same protein.
Analytical biochemistry 2012;430(2):141-50.
2012: Yu Zhou; Lequn Zhao; James D Marks
Selection and characterization of cell binding and internalizing phage antibodies.
Archives of biochemistry and biophysics 2012;526(2):107-13.
2012: Zachary M Carrico; Harshal Chokhawala; Douglas S Clark; Michelle E Farkas; Sonny C Hsiao; James D Marks; Yu Zhou; Matt B Francis
N-Terminal labeling of filamentous phage to create cancer marker imaging agents.
ACS nano 2012;6(8):6675-80.
2012: Q Meng; K Meyer; R Shimizu; M A Silberg; R To; M T Tomic; J Bettencourt; L Cao; F Conrad; C Huang; M Li; J Ma; James D Marks
Domain-based assays of individual antibody concentrations in an oligoclonal combination targeting a single protein.
Analytical biochemistry 2012;421(2):351-61.
2011: Stephen I Rudnick; Jianlong Lou; Calvin Shaller; Yong Tang; Andres J P Klein-Szanto; Louis M Weiner; James D Marks; Gregory P Adams
Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors.
Cancer research 2011;71(6):2250-9.
2011: Smitha Reddy; Calvin Shaller; Mohan Doss; Irina Shchaveleva; James D Marks; Jian Q Yu; Matthew K Robinson
Evaluation of the anti-HER2 C6.5 diabody as a PET radiotracer to monitor HER2 status and predict response to trastuzumab treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(6):1509-20.
2011: C Garcia-Rodriguez; Isin Geren; Jianlong Lou; Fraser Conrad; Charles M Forsyth; W Wen; S Chakraborti; H Zao; G Manzanarez; T J Smith; J Brown; W H Tepp; N Liu; S Wijesuriya; M T Tomic; Eric A Johnson; LA Smith; James D Marks
Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin.
Protein engineering, design & selection : PEDS 2011;24(3):321-31.
2010: Ronan Crépin; Anne-Laure Goenaga; Betsy Jullienne; Houcine Bougherara; Christine Legay; Karim Benihoud; James D Marks; Marie-Alix Poul
Development of human single-chain antibodies to the transferrin receptor that effectively antagonize the growth of leukemias and lymphomas.
Cancer research 2010;70(13):5497-506.
2010: Jianbo Dong; Aaron A Thompson; Yongfeng Fan; Jianlong Lou; Fraser Conrad; Mengfei Ho; Melissa Pires-Alves; Brenda A Wilson; Raymond C Stevens; James D Marks
A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region.
Journal of molecular biology 2010;397(4):1106-18.
2010: Jianlong Lou; Isin Geren; C Garcia-Rodriguez; Charles M Forsyth; W Wen; K Knopp; J Brown; T Smith; LA Smith; James D Marks
Affinity maturation of human botulinum neurotoxin antibodies by light chain shuffling via yeast mating.
Protein engineering, design & selection : PEDS 2010;23(4):311-9.
2010: Molly R Darragh; Eric L Schneider; Jianlong Lou; Paul J Phojanakong; Christopher J Farady; James D Marks; Byron Hann; Charles S Craik
Tumor detection by imaging proteolytic activity.
Cancer research 2010;70(4):1505-12.
2009: Yu Cao; James D Marks; John W Marks; Lawrence H Cheung; Sehoon Kim; Michael G Rosenblum
Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: in vitro and in vivo studies.
Cancer research 2009;69(23):8987-95.
2009: Marvin G Warner; Jay W Grate; Abby Tyler; Richard M Ozanich; Keith D Miller; Jianlong Lou; James D Marks; Cynthia J Bruckner-Lea
Quantum dot immunoassays in renewable surface column and 96-well plate formats for the fluorescence detection of botulinum neurotoxin using high-affinity antibodies.
Biosensors & bioelectronics 2009;25(1):179-84.
2009: Richard M Ozanich; Cynthia J Bruckner-Lea; Marvin G Warner; Keith Miller; Kathryn C Antolick; James D Marks; Jianlong Lou; Jay W Grate
Rapid multiplexed flow cytometric assay for botulinum neurotoxin detection using an automated fluidic microbead-trapping flow cell for enhanced sensitivity.
Analytical chemistry 2009;81(14):5783-93.
2009: Jay W Grate; Marvin G Warner; Richard M Ozanich; Keith D Miller; Heather A Colburn; Brian Dockendorff; Kathryn C Antolick; Norman C Anheier; Michael A Lind; Jianlong Lou; James D Marks; Cynthia J Bruckner-Lea
Renewable surface fluorescence sandwich immunoassay biosensor for rapid sensitive botulinum toxin detection in an automated fluidic format.
The Analyst 2009;134(5):987-96.
2009: Fraser Conrad; Xiaodong Zhu; Xin Zhang; Robert J Chalkley; Alma L Burlingame; James D Marks; Bin Liu
Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion.
Journal of molecular medicine (Berlin, Germany) 2009;87(5):507-14.
2009: Yu Zhou; James D Marks
Identification of target and function specific antibodies for effective drug delivery.
Methods in molecular biology (Clifton, N.J.) 2009;525():145-60, xv.
2008: Matthew K Robinson; K M Hodge; Eva M Horak; A L Sundberg; Maria Russeva; Calvin Shaller; Margaret von Mehren; Irina Shchaveleva; Heidi H Simmons; James D Marks; Gregory P Adams
Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro.
British journal of cancer 2008;99(9):1415-25.
2008: Audrey Fischer; Consuelo Garcia-Rodriguez; Isin Geren; Jianlong Lou; James D Marks; Terunaga Nakagawa; Mauricio Montal
Molecular architecture of botulinum neurotoxin E revealed by single particle electron microscopy.
The Journal of biological chemistry 2008;283(7):3997-4003.
2008: Matthew K Robinson; Calvin Shaller; Kayhan Garmestani; Paul S Plascjak; Kathryn M Hodge; Qing-An Yuan; James D Marks; Thomas Waldmann; Martin W Brechbiel; Gregory P Adams
Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the alpha-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(3):875-82.
2007: Audrey Roth; Daryl C Drummond; Fraser Conrad; Mark E Hayes; Dmitri B Kirpotin; Christopher C Benz; James D Marks; Bin Liu
Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells.
Molecular cancer therapeutics 2007;6(10):2737-46.
2007: Bin Liu; Fraser Conrad; Audrey Roth; Daryl C Drummond; Jeff Simko; James D Marks
Recombinant full-length human IgG1s targeting hormone-refractory prostate cancer.
Journal of molecular medicine (Berlin, Germany) 2007;85(10):1113-23.
2007: Yong Tang; Jianlong Lou; R Katherine Alpaugh; Matthew K Robinson; James D Marks; Louis M Weiner
Regulation of antibody-dependent cellular cytotoxicity by IgG intrinsic and apparent affinity for target antigen.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):2815-23.
2007: Yu Zhou; Daryl C Drummond; Hao Zou; Mark E Hayes; Gregory P Adams; Dmitri B Kirpotin; James D Marks
Impact of single-chain Fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor-expressing tumor cells.
Journal of molecular biology 2007;371(4):934-47.
2007: Anne-Laure Goenaga; Yu Zhou; Christine Legay; Houcine Bougherara; Lan Huang; Bin Liu; Daryl C Drummond; Dmitri B Kirpotin; Christian Auclair; James D Marks; Marie-Alix Poul
Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies.
Molecular immunology 2007;44(15):3777-88.
2007: R Levy; Charles M Forsyth; Sherry L. LaPorte; Isin Geren; LA Smith; James D Marks
Fine and domain-level epitope mapping of botulinum neurotoxin type A neutralizing antibodies by yeast surface display.
Journal of molecular biology 2007;365(1):196-210.
2007: Consuelo Garcia-Rodriguez; Raphael Levy; Joseph W Arndt; Charles M Forsyth; Ali Razai; Jianlong Lou; Isin Geren; Raymond C Stevens; James D Marks
Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin.
Nature biotechnology 2007;25(1):107-16.
2006: Mark E Hayes; Daryl C Drummond; Keelung Hong; W W Zheng; V A Khorosheva; J A Cohen; Noble C O; John W Park; James D Marks; Christopher C Benz; Dmitri B Kirpotin
Increased target specificity of anti-HER2 genospheres by modification of surface charge and degree of PEGylation.
Molecular pharmaceutics 2006;3(6):726-36.
2006: Joseph W Arndt; Mark J Jacobson; Enrique E Abola; Charles M Forsyth; William H Tepp; James D Marks; Eric A Johnson; Raymond C Stevens
A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4.
Journal of molecular biology 2006;362(4):733-42.
2006: Dmitri B Kirpotin; Daryl C Drummond; Yi Shao; M Refaat Shalaby; Keelung Hong; Ulrik B Nielsen; James D Marks; Christopher C Benz; John W Park
Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models.
Cancer research 2006;66(13):6732-40.
2006: Mark E Hayes; Daryl C Drummond; Keelung Hong; John W Park; James D Marks; Dmitri B Kirpotin
Assembly of nucleic acid-lipid nanoparticles from aqueous-organic monophases.
Biochimica et biophysica acta 2006;1758(4):429-42.
2006: Mark E Hayes; Daryl C Drummond; Dmitri B Kirpotin; W W Zheng; Charles O Noble; John W Park; James D Marks; Christopher C Benz; Keelung Hong
Genospheres: self-assembling nucleic acid-lipid nanoparticles suitable for targeted gene delivery.
Gene therapy 2006;13(7):646-51.
2006: Gregory P Adams; Mei-Sheng Tai; John E McCartney; James D Marks; Walter F Stafford; L L Houston; James S Huston; Louis M Weiner
Avidity-mediated enhancement of in vivo tumor targeting by single-chain Fv dimers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(5):1599-605.
2006: Ulrik B Nielsen; Dmitri B Kirpotin; Edward M Pickering; Daryl C Drummond; James D Marks
A novel assay for monitoring internalization of nanocarrier coupled antibodies.
BMC immunology 2006;7():24.
2005: Eva M Horak; Tara Heitner; Matthew K Robinson; Heidi H Simmons; Jennifer Garrison; Maria Russeva; Polina Furmanova; Jianlong Lou; Yu Zhou; Qing-An Yuan; Louis M Weiner; Gregory P Adams; James D Marks
Isolation of scFvs to in vitro produced extracellular domains of EGFR family members.
Cancer biotherapy & radiopharmaceuticals 2005;20(6):603-13.
2005: T J Smith; Jianlong Lou; Isin Geren; Charles M Forsyth; R Tsai; Sherry L. LaPorte; William H Tepp; Marite Bradshaw; Eric A Johnson; LA Smith; James D Marks
Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization.
Infection and immunity 2005;73(9):5450-7.
2005: A Razai; C Garcia-Rodriguez; Jianlong Lou; Isin Geren; Charles M Forsyth; Y Robles; R Tsai; T J Smith; LA Smith; R W Siegel; Michael J Feldhaus; James D Marks
Molecular evolution of antibody affinity for sensitive detection of botulinum neurotoxin type A.
Journal of molecular biology 2005;351(1):158-69.
2005: Matthew K Robinson; Mohan Doss; Calvin Shaller; Deepa Narayanan; James D Marks; Lee P Adler; Dinko E González Trotter; Gregory P Adams
Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody.
Cancer research 2005;65(4):1471-8.
2004: Gregory P Adams; Calvin Shaller; Ekaterina Dadachova; Heidi H Simmons; Eva M Horak; Abohawariat Tesfaye; Andres J P Klein-Szanto; James D Marks; Martin W Brechbiel; Louis M Weiner
A single treatment of yttrium-90-labeled CHX-A"-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice.
Cancer research 2004;64(17):6200-6.
2004: Charles O Noble; Dmitri B Kirpotin; Mark E Hayes; Christoph Mamot; Keelung Hong; John W Park; Christopher C Benz; James D Marks; Daryl C Drummond
Development of ligand-targeted liposomes for cancer therapy.
Expert opinion on therapeutic targets 2004;8(4):335-53.
2004: Jane M Weaver-Feldhaus; Jianlong Lou; James R Coleman; Robert W Siegel; James D Marks; Michael J Feldhaus
Yeast mating for combinatorial Fab library generation and surface display.
FEBS letters 2004;564(1-2):24-34.
2004: James D Marks
Deciphering antibody properties that lead to potent botulinum neurotoxin neutralization.
Movement disorders : official journal of the Movement Disorder Society 2004;19 Suppl 8():S101-8.
2004: Bin Liu; Fraser Conrad; Matthew Cooperberg; Dmitri B Kirpotin; James D Marks
Mapping tumor epitope space by direct selection of single-chain Fv antibody libraries on prostate cancer cells.
Cancer research 2004;64(2):704-10.
2004: James D Marks
Antibody affinity maturation by chain shuffling.
Methods in molecular biology (Clifton, N.J.) 2004;248():327-43.
2004: James D Marks
Selection of internalizing antibodies for drug delivery.
Methods in molecular biology (Clifton, N.J.) 2004;248():201-8.
2004: James D Marks; Andrew Bradbury
Selection of human antibodies from phage display libraries.
Methods in molecular biology (Clifton, N.J.) 2004;248():161-76.
2004: James D Marks; Andrew Bradbury
PCR cloning of human immunoglobulin genes.
Methods in molecular biology (Clifton, N.J.) 2004;248():117-34.
2003: Christoph Mamot; Daryl C Drummond; Udo Greiser; Keelung Hong; Dmitri B Kirpotin; James D Marks; John W Park
Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells.
Cancer research 2003;63(12):3154-61.
2002: A Nowakowski; C Wang; D B Powers; Peter Amersdorfer; T J Smith; V A Montgomery; Robert Sheridan; R Blake; L A Smith; James D Marks
Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11346-50.
2002: Ulrik B Nielsen; Dmitri B Kirpotin; Edward M Pickering; Keelung Hong; John W Park; M Refaat Shalaby; Yi Shao; Christopher C Benz; James D Marks
Therapeutic efficacy of anti-ErbB2 immunoliposomes targeted by a phage antibody selected for cellular endocytosis.
Biochimica et biophysica acta 2002;1591(1-3):109-118.
2002: David O'Connell; Baltazar Becerril; Arup Roy-Burman; Michael Daws; James D Marks
Phage versus phagemid libraries for generation of human monoclonal antibodies.
Journal of molecular biology 2002;321(1):49-56.
2002: Dara W Frank; Amy Vallis; jeanine wiener-kronish; Arup Roy-Burman; Edward G Spack; Brian P Mullaney; Mehdi Megdoud; James D Marks; Robert Fritz; Teiji Sawa
Generation and characterization of a protective monoclonal antibody to Pseudomonas aeruginosa PcrV.
The Journal of infectious diseases 2002;186(1):64-73.
2002: John W Park; Keelung Hong; Dmitri B Kirpotin; Gail T Colbern; Refaat Shalaby; Jose Baselga; Yvonne Shao; Ulrik B Nielsen; James D Marks; Dan Moore; Demetrios Papahadjopoulos; Christopher C Benz
Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):1172-81.
2002: Peter Amersdorfer; Cindy Wong; Theresa Smith; Steven Chen; Sharad Deshpande; Robert Sheridan; James D Marks
Genetic and immunological comparison of anti-botulinum type A antibodies from immune and non-immune human phage libraries.
Vaccine 2002;20(11-12):1640-8.
2002: Erika A Lindquist; James D Marks; Betsy J Kleba; Richard S Stephens
Phage-display antibody detection of Chlamydia trachomatis-associated antigens.
Microbiology (Reading, England) 2002;148(Pt 2):443-51.
2002: Bin Liu; Lan Huang; Carina Sihlbom; Al L Burlingame; James D Marks
Towards proteome-wide production of monoclonal antibody by phage display.
Journal of molecular biology 2002;315(5):1063-73.
2001: John W Park; Dmitri B Kirpotin; Keelung Hong; Refaat Shalaby; Yvonne Shao; Ulrik B Nielsen; James D Marks; Demetrios Papahadjopoulos; Christopher C Benz
Tumor targeting using anti-her2 immunoliposomes.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):95-113.
2001: Gregory P Adams; R Schier; AM McCall; Heidi H Simmons; Eva M Horak; R Katherine Alpaugh; James D Marks; Louis M Weiner
High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules.
Cancer research 2001;61(12):4750-5.
2001: AM McCall; L Shahied; AR Amoroso; Eva M Horak; Heidi H Simmons; U Nielson; Gregory P Adams; R Schier; James D Marks; Louis M Weiner
Increasing the affinity for tumor antigen enhances bispecific antibody cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6112-7.
2001: D B Powers; Peter Amersdorfer; Marie-Alix Poul; Ulrik B Nielsen; M R Shalaby; Gregory P Adams; Louis M Weiner; James D Marks
Expression of single-chain Fv-Fc fusions in Pichia pastoris.
Journal of immunological methods 2001;251(1-2):123-35.
2001: Robert E Sheridan; Sharad S Deshpande; Peter Amersdorfer; James D Marks; Theresa Smith
Anomalous enhancement of botulinum toxin type A neurotoxicity in the presence of antitoxin.
Toxicon : official journal of the International Society on Toxinology 2001;39(5):651-7.
2001: M A Huie; M C Cheung; Marcus O Muench; Baltazar Becerril; Yuet Wai Kan; James D Marks
Antibodies to human fetal erythroid cells from a nonimmune phage antibody library.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2682-7.
2001: T Heitner; Anne Moor; J L Garrison; C Marks; T Hasan; James D Marks
Selection of cell binding and internalizing epidermal growth factor receptor antibodies from a phage display library.
Journal of immunological methods 2001;248(1-2):17-30.
2001: Richard M Neve; Ulrik B Nielsen; Dmitri B Kirpotin; Marie-Alix Poul; James D Marks; Christopher C Benz
Biological effects of anti-ErbB2 single chain antibodies selected for internalizing function.
Biochemical and biophysical research communications 2001;280(1):274-9.
2000: Ulrik B Nielsen; Gregory P Adams; Louis M Weiner; James D Marks
Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity.
Cancer research 2000;60(22):6434-40.
2000: Bin Liu; James D Marks
Applying phage antibodies to proteomics: selecting single chain Fv antibodies to antigens blotted on nitrocellulose.
Analytical biochemistry 2000;286(1):119-28.
2000: Marie-Alix Poul; Baltazar Becerril; Ulrik B Nielsen; P Morisson; James D Marks
Selection of tumor-specific internalizing human antibodies from phage libraries.
Journal of molecular biology 2000;301(5):1149-61.
2000: Gregory P Adams; Calvin Shaller; L L Chappell; Carl Wu; Eva M Horak; Heidi H Simmons; S Litwin; James D Marks; Louis M Weiner; Martin W Brechbiel
Delivery of the alpha-emitting radioisotope bismuth-213 to solid tumors via single-chain Fv and diabody molecules.
Nuclear medicine and biology 2000;27(4):339-46.
2000: Peter Amersdorfer; James D Marks
Phage libraries for generation of anti-botulinum scFv antibodies.
Methods in molecular biology (Clifton, N.J.) 2000;145():219-40.
1999: N C Hughes-Jones; J M Bye; B D Gorick; James D Marks; Willem H Ouwehand
Synthesis of Rh Fv phage-antibodies using VH and VL germline genes.
British journal of haematology 1999;105(3):811-6.
1999: AM McCall; Gregory P Adams; AR Amoroso; Ulrik B Nielsen; L Zhang; Eva M Horak; Heidi H Simmons; R Schier; James D Marks; Louis M Weiner
Isolation and characterization of an anti-CD16 single-chain Fv fragment and construction of an anti-HER2/neu/anti-CD16 bispecific scFv that triggers CD16-dependent tumor cytolysis.
Molecular immunology 1999;36(7):433-45.
1999: Marie-Alix Poul; James D Marks
Targeted gene delivery to mammalian cells by filamentous bacteriophage.
Journal of molecular biology 1999;288(2):203-11.
1999: Baltazar Becerril; Marie-Alix Poul; James D Marks
Toward selection of internalizing antibodies from phage libraries.
Biochemical and biophysical research communications 1999;255(2):386-93.
1998: AM McCall; AR Amoroso; C Sautès; James D Marks; Louis M Weiner
Characterization of anti-mouse Fc gamma RII single-chain Fv fragments derived from human phage display libraries.
Immunotechnology : an international journal of immunological engineering 1998;4(1):71-87.
1998: M D Sheets; Peter Amersdorfer; R Finnern; P Sargent; Erika A Lindquist; R Schier; G Hemingsen; Cindy Wong; John Gerhart; James D Marks; E Lindqvist
Efficient construction of a large nonimmune phage antibody library: the production of high-affinity human single-chain antibodies to protein antigens.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6157-62.
1998: Gregory P Adams; R Schier; AM McCall; Robert Crawford; E J Wolf; Louis M Weiner; James D Marks
Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu.
British journal of cancer 1998;77(9):1405-12.
1998: Gregory P Adams; R Schier; K Marshall; E J Wolf; AM McCall; James D Marks; Louis M Weiner
Increased affinity leads to improved selective tumor delivery of single-chain Fv antibodies.
Cancer research 1998;58(3):485-90.
1997: Peter Amersdorfer; Cindy Wong; S Chen; Theresa Smith; S Deshpande; Robert Sheridan; R Finnern; James D Marks
Molecular characterization of murine humoral immune response to botulinum neurotoxin type A binding domain as assessed by using phage antibody libraries.
Infection and immunity 1997;65(9):3743-52.
1997: F Chen; GM Kuziemko; Peter Amersdorfer; Cindy Wong; James D Marks; Raymond C Stevens
Antibody mapping to domains of botulinum neurotoxin serotype A in the complexed and uncomplexed forms.
Infection and immunity 1997;65(5):1626-30.
1996: R Schier; AM McCall; Gregory P Adams; K W Marshall; H Merritt; M Yim; Robert Crawford; Louis M Weiner; C Marks; James D Marks
Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site.
Journal of molecular biology 1996;263(4):551-67.
1996: C Marks; James D Marks
Phage libraries--a new route to clinically useful antibodies.
The New England journal of medicine 1996;335(10):730-3.
1996: R Schier; R F Balint; AM McCall; G Apell; J W Larrick; James D Marks
Identification of functional and structural amino-acid residues by parsimonious mutagenesis.
Gene 1996;169(2):147-55.
1996: R Schier; J Bye; G Apell; AM McCall; Gregory P Adams; M Malmqvist; Louis M Weiner; James D Marks
Isolation of high-affinity monomeric human anti-c-erbB-2 single chain Fv using affinity-driven selection.
Journal of molecular biology 1996;255(1):28-43.
1996: R Schier; James D Marks
Efficient in vitro affinity maturation of phage antibodies using BIAcore guided selections.
Human antibodies and hybridomas 1996;7(3):97-105.
1995: R Finnern; J M Bye; K M Dolman; M H Zhao; A Short; James D Marks; M C Lockwood; Willem H Ouwehand
Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries.
Clinical and experimental immunology 1995;102(3):566-74.
1995: R Schier; James D Marks; E J Wolf; G Apell; Cindy Wong; J E McCartney; M A Bookman; J S Huston; L L Houston; Louis M Weiner
In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library.
Immunotechnology : an international journal of immunological engineering 1995;1(1):73-81.
1994: N C Hughes-Jones; B D Gorick; J M Bye; R Finnern; M L Scott; D Voak; James D Marks; Willem H Ouwehand
Characterization of human blood group scFv antibodies derived from a V gene phage-display library.
British journal of haematology 1994;88(1):180-6.
1994: M Figini; James D Marks; Greg Winter; A D Griffiths
In vitro assembly of repertoires of antibody chains on the surface of phage by renaturation.
Journal of molecular biology 1994;239(1):68-78.
1994: Willem H Ouwehand; J M Bye; B D Gorick; James D Marks; E Timmers; H M Griffin; R Finnern; N Hughes-Jones
The humoral immune response against blood group antigens at the molecular level.
Vox sanguinis 1994;67 Suppl 3():7-12.
1993: James D Marks; Willem H Ouwehand; J M Bye; R Finnern; B D Gorick; D Voak; S J Thorpe; N C Hughes-Jones; Greg Winter
Human antibody fragments specific for human blood group antigens from a phage display library.
Bio/technology (Nature Publishing Company) 1993;11(10):1145-9.
1993: A D Griffiths; M Malmqvist; James D Marks; J M Bye; M J Embleton; J McCafferty; M Baier; K P Holliger; B D Gorick; N C Hughes-Jones
Human anti-self antibodies with high specificity from phage display libraries.
The EMBO journal 1993;12(2):725-34.
1993: H R Hoogenboom; James D Marks; A D Griffiths; Greg Winter
Building antibodies from their genes.
Revue française de transfusion et d'hémobiologie : bulletin de la Société nationale de transfusion sanguine 1993;36(1):19-47.
1992: J M Bye; C Carter; Y Cui; B D Gorick; S Songsivilai; Greg Winter; N C Hughes-Jones; James D Marks
Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift.
The Journal of clinical investigation 1992;90(6):2481-90.
1992: H R Hoogenboom; James D Marks; A D Griffiths; Greg Winter
Building antibodies from their genes.
Immunological reviews 1992;130():41-68.
1992: Cyrus Chothia; Arthur M Lesk; Ermanno Gherardi; Ian M Tomlinson; G Walter; James D Marks; M B Llewelyn; Greg Winter
Structural repertoire of the human VH segments.
Journal of molecular biology 1992;227(3):799-817.
1992: Ian M Tomlinson; G Walter; James D Marks; M B Llewelyn; Greg Winter
The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops.
Journal of molecular biology 1992;227(3):776-98.
1992: James D Marks; H R Hoogenboom; A D Griffiths; Greg Winter
Molecular evolution of proteins on filamentous phage. Mimicking the strategy of the immune system.
The Journal of biological chemistry 1992;267(23):16007-10.
1992: James D Marks; A D Griffiths; M Malmqvist; T P Clackson; J M Bye; Greg Winter
By-passing immunization: building high affinity human antibodies by chain shuffling.
Bio/technology (Nature Publishing Company) 1992;10(7):779-83.
1992: James D Marks; Greg Winter
An artificial immune system for making antibodies.
Behring Institute Mitteilungen 1992;(91):6-12.
1991: James D Marks; H R Hoogenboom; T P Bonnert; J McCafferty; A D Griffiths; Greg Winter
By-passing immunization. Human antibodies from V-gene libraries displayed on phage.
Journal of molecular biology 1991;222(3):581-97.
1990: S Songsivilai; J M Bye; James D Marks; N C Hughes-Jones
Cloning and sequencing of human lambda immunoglobulin genes by the polymerase chain reaction.
European journal of immunology 1990;20(12):2661-6.