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Lawrence Marnett

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Maria Cekanova; Alfred M Legendre; Joseph W Bartges; Amanda Callens; Amanda Carter; Kusum Rathore; Md Jashim Uddin; Laura Wright; Lawrence J Marnett
Molecular imaging of cyclooxygenase-2 in canine transitional cell carcinomas in vitro and in vivo.
Md Jashim Uddin; Brenda C Crews; Kebreab Ghebreselasie; Lawrence J Marnett
Design, synthesis, and structure-activity relationship studies of fluorescent inhibitors of cycloxygenase-2 as targeted optical imaging agents.
Andy J Liedtke; Lawrence J Marnett; Adegoke O Adeniji; Michael C Byrns; Mo Chen; David W Christianson; Yi Jin; Trevor M Penning
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.

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2013: Maria Cekanova; Alfred M Legendre; Joseph W Bartges; Amanda Callens; Amanda Carter; Kusum Rathore; Md Jashim Uddin; Laura Wright; Lawrence J Marnett
Molecular imaging of cyclooxygenase-2 in canine transitional cell carcinomas in vitro and in vivo.
Cancer prevention research (Philadelphia, Pa.) 2013;6(5):466-76.
2013: Md Jashim Uddin; Brenda C Crews; Kebreab Ghebreselasie; Lawrence J Marnett
Design, synthesis, and structure-activity relationship studies of fluorescent inhibitors of cycloxygenase-2 as targeted optical imaging agents.
Bioconjugate chemistry 2013;24(4):712-23.
2013: Andy J Liedtke; Lawrence J Marnett; Adegoke O Adeniji; Michael C Byrns; Mo Chen; David W Christianson; Yi Jin; Trevor M Penning
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.
Journal of medicinal chemistry 2013;56(6):2429-46.
2013: Mariana Boiani; Cristina Daniel; Michael D Hogarty; Xueyuan Liu; Lawrence J Marnett
The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737.
The Journal of biological chemistry 2013;288(10):6980-90.
2013: Keri A Tallman; Michelle D Armstrong; H Alex Brown; Lawrence J Marnett; Stephen B Milne; Ned A Porter
Cobalt carbonyl complexes as probes for alkyne-tagged lipids.
Journal of lipid research 2013;54(3):859-68.
2013: Christopher D Aluise; Mariana Boiani; Joseph D Manna; Ned A Porter; Michelle L Reyzer; Kristie Rose; Keri Tallman; Lawrence J Marnett
Peptidyl-prolyl cis/trans-isomerase A1 (Pin1) is a target for modification by lipid electrophiles.
Chemical research in toxicology 2013;26(2):270-9.
2013: Markus Laube; Peter Lönnecke; Lawrence J Marnett; Wilma Neumann; Jens Pietzsch; Matthias Scholz; Brenda Crews; Torsten Kniess; Evamarie Hey-Hawkins
2-Carbaborane-3-phenyl-1H-indoles--synthesis via McMurry reaction and cyclooxygenase (COX) inhibition activity.
ChemMedChem 2013;8(2):329-35.
2013: Rebecca E Connor; Simona G Codreanu; Lawrence J Marnett; Daniel C Liebler
Targeted protein capture for analysis of electrophile-protein adducts.
Methods in molecular biology (Clifton, N.J.) 2013;987():163-76.
2013: Eva M Sevick-Muraca; Thomas D Wang; Walter J Akers; Christopher H Contag; Cathy S Cutler; Bishnu P Joshi; Gary D Luker; Lawrence J Marnett; Ali Azhdarinia
Advancing the translation of optical imaging agents for clinical imaging.
Biomedical optics express 2013;4(1):160-70.
2012: Maria Cekanova; Gina Galyon; Alfred M Legendre; Joseph W Bartges; Amanda Callens; Tomas Martin-Jimenez; Md Jashim Uddin; Lawrence J Marnett
Single-dose safety and pharmacokinetic evaluation of fluorocoxib A: pilot study of novel cyclooxygenase-2-targeted optical imaging agent in a canine model.
Journal of biomedical optics 2012;17(11):116002.
2012: Joel Musee; Lawrence J Marnett
Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid.
The Journal of biological chemistry 2012;287(44):37383-94.
2012: Jody C Ullery; Lawrence J Marnett
Protein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: Investigating cellular responses.
Biochimica et biophysica acta 2012;1818(10):2424-35.
2012: Shu Xu; Lawrence J Marnett; Timothy C Mueser; Max O Funk
Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis.
Structure (London, England : 1993) 2012;20(9):1490-7.
2012: Matthias Scholz; Lawrence J Marnett; Anna L Blobaum; Evamarie Hey-Hawkins
Ortho-carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors.
Bioorganic & medicinal chemistry 2012;20(15):4830-7.
2012: Gerhard Eisenbrand; Kent S Gates; Stephen S Hecht; Christine Janzowski; Larry K Keefer; Lawrence J Marnett; Steven R Tannenbaum
Richard Loeppky (1937-2012).
Chemical research in toxicology 2012;25(6):1155-6.
2012: Lawrence J Marnett
Inflammation and cancer: chemical approaches to mechanisms, imaging, and treatment.
The Journal of organic chemistry 2012;77(12):5224-38.
2012: Melissa B Aldrich; Henry D Appelman; Chris Contag; James M Crawford; Brenda C Crews; Joseph Culver; John Kotyk; Greg Lanza; Joseph C Liao; Lawrence J Marnett; Milton V Marshall; Charles Meyer; Bill Reisdorph; Eva M Sevick-Muraca; D Kim Turgeon; Jashim Uddin; Ken Wang; Lihong V Wang; Tom Wang
Seeing it through: translational validation of new medical imaging modalities.
Biomedical optics express 2012;3(4):764-76.
2012: Andy J Liedtke; Anna L Blobaum; Brenda C Crews; Cristina M Daniel; Kebreab Ghebreselasie; Philip J Kingsley; Lawrence J Marnett
Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.
Journal of medicinal chemistry 2012;55(5):2287-300.
2012: Dapo Akingbade; Robert Carnahan; Tracy Cooper; Philip J Kingsley; Sarah C Shuck; Jozef Szekely; Lawrence J Marnett
Selection of monoclonal antibodies against 6-oxo-M(1)dG and their use in an LC-MS/MS assay for the presence of 6-oxo-M(1)dG in vivo.
Chemical research in toxicology 2012;25(2):454-61.
2012: Lawrence J Marnett
On a high note.
Chemical research in toxicology 2012;25(1):1.
2011: Kelsey C Duggan; Daniel J Hermanson; Surajit Banerjee; Bruce D Carter; Joel Musee; J A Oates; Jeffery J Prusakiewicz; Jami L Scheib; Lawrence J Marnett
(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2.
Nature chemical biology 2011;7(11):803-9.
2011: H Alex Brown; Lawrence J Marnett
Introduction to lipid biochemistry, metabolism, and signaling.
Chemical reviews 2011;111(10):5817-20.
2011: Carol A Rouzer; Lawrence J Marnett
Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways.
Chemical reviews 2011;111(10):5899-921.
2011: Md Jashim Uddin; Jeffery Reese; Mohammed N Tantawy; Mohammad Sib Ansari; Brenda C Crews; Kebreab Ghebreselasie; Imran Huda; Philip J Kingsley; Lawrence J Marnett
Fluorinated COX-2 inhibitors as agents in PET imaging of inflammation and cancer.
Cancer prevention research (Philadelphia, Pa.) 2011;4(10):1536-45.
2011: Troy B Adams; Samuel M Cohen; Victor J Feron; C Lucas Gavin; Lawrence J Marnett; M M McGowen; Ian C Munro; Philip S Portoghese; I M C M Rietjens; William J Waddell; Robert L Smith
The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011;49(10):2471-94.
2011: Carol A Rouzer; Lawrence J Marnett
Green tea gets molecular.
Cancer prevention research (Philadelphia, Pa.) 2011;4(9):1343-5.
2011: Joseph D Manna; Lawrence J Marnett; Michelle L Reyzer; C David Weaver; Joey C Latham; Richard M Caprioli
High-throughput quantification of bioactive lipids by MALDI mass spectrometry: application to prostaglandins.
Analytical chemistry 2011;83(17):6683-8.
2011: Rebecca E Connor; Lawrence J Marnett; Daniel C Liebler
Protein-selective capture to analyze electrophile adduction of hsp90 by 4-hydroxynonenal.
Chemical research in toxicology 2011;24(8):1275-82.
2011: Bing Zhang; Dexter T Duncan; Lawrence J Marnett; Naresh Prodduturi; Zhiao Shi; Daniel C Liebler
Relating protein adduction to gene expression changes: a systems approach.
Molecular bioSystems 2011;7(7):2118-27.
2011: Matthias Scholz; Anna L Blobaum; Lawrence J Marnett; Evamarie Hey-Hawkins
Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors.
Bioorganic & medicinal chemistry 2011;19(10):3242-8.
2011: Andrés Trostchansky; Lucía Bonilla; Christopher P Thomas; Valerie B O'Donnell; Lawrence J Marnett; Rafael Radi; Homero Rubbo
Nitroarachidonic acid, a novel peroxidase inhibitor of prostaglandin endoperoxide H synthases 1 and 2.
The Journal of biological chemistry 2011;286(15):12891-900.
2011: Colleen E McGrath; Keri A Tallman; Ned A Porter; Lawrence J Marnett
Structure-activity analysis of diffusible lipid electrophiles associated with phospholipid peroxidation: 4-hydroxynonenal and 4-oxononenal analogues.
Chemical research in toxicology 2011;24(3):357-70.
2010: Kelsey C Duggan; Matthew J Walters; Joel Musee; Joel M Harp; James R Kiefer; John A Oates; Lawrence J Marnett
Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
The Journal of biological chemistry 2010;285(45):34950-9.
2010: Md Jashim Uddin; Michael I Schulte; Leena Maddukuri; Joel Harp; Lawrence J Marnett
Semisynthesis of 6-chloropurine-2'-deoxyriboside 5'-dimethoxytrityl 3'-(2-cyanoethyl-N,N-diisopropylamino)phosphoramidite and its use in the synthesis of fluorescently labeled oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2010;29(11):831-40.
2010: Susan D Cline; M Fernanda Lodeiro; Lawrence J Marnett; Craig E Cameron; Jamie J Arnold
Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M1dG.
Nucleic acids research 2010;38(21):7546-57.
2010: Robert L Eoff; Colleen E McGrath; Leena Maddukuri; Sandra Giovanna Salamanca-Pinzón; Victor E Marquez; Lawrence J Marnett; F Peter Guengerich; Martin Egli
Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues.
Angewandte Chemie (International ed. in English) 2010;49(41):7481-5.
2010: Leena Maddukuri; Robert L Eoff; Jeong-Yun Choi; Carmelo J Rizzo; F Peter Guengerich; Lawrence J Marnett
In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1.
Biochemistry 2010;49(38):8415-24.
2010: Leslie N Aldrich; Sydney L Stoops; Brenda C Crews; Lawrence J Marnett; Craig W Lindsley
Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs.
Bioorganic & medicinal chemistry letters 2010;20(17):5207-11.
2010: Brian O Bachmann; Ruth McNees; Bruce J Melancon; Victor P Ghidu; Rachel Clark; Brenda C Crews; Sean M Deguire; Lawrence J Marnett; Gary A Sulikowski
Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry.
Organic letters 2010;12(13):2944-7.
2010: Robyn Richie-Jannetta; Chaitanya S Nirodi; Brenda C Crews; David F Woodward; Jenny W Wang; Peter T Duff; Lawrence J Marnett
Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2alpha glyceryl esters in RAW 264.7 cells and H1819 cells.
Prostaglandins & other lipid mediators 2010;92(1-4):19-24.
2010: Aaron T Jacobs; Lawrence J Marnett
Systems analysis of protein modification and cellular responses induced by electrophile stress.
Accounts of chemical research 2010;43(5):673-83.
2010: Md Jashim Uddin; Brenda C Crews; Anna L Blobaum; Philip J Kingsley; D Lee Gorden; J Oliver McIntyre; Lynn M Matrisian; Kotha Subbaramaiah; Andrew J Dannenberg; David W Piston; Lawrence J Marnett
Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents.
Cancer research 2010;70(9):3618-27.
2010: Md Jashim Uddin; David Smithson; Kristin M Brown; Brenda C Crews; Michele Connelly; Fangyi Zhu; Lawrence J Marnett; R Kiplin Guy
Podophyllotoxin analogues active versus Trypanosoma brucei.
Bioorganic & medicinal chemistry letters 2010;20(5):1787-91.
2010: Kelsey C Duggan; Joel Musee; Lawrence J Marnett
Peroxidase active site activity assay.
Methods in molecular biology (Clifton, N.J.) 2010;644():55-65.
2009: Melissa V Turman; Philip J Kingsley; Lawrence J Marnett
Characterization of an AM404 analogue, N-(3-hydroxyphenyl)arachidonoylamide, as a substrate and inactivator of prostaglandin endoperoxide synthase.
Biochemistry 2009;48(51):12233-41.
2009: Sachin Patel; Philip J Kingsley; Ken Mackie; Lawrence J Marnett; Danny G Winder
Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(13):2699-709.
2009: R Nathan Daniels; Bruce J Melancon; Emily A Wang; Brenda C Crews; Lawrence J Marnett; Gary A Sulikowski; Craig W Lindsley
Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A.
The Journal of organic chemistry 2009;74(22):8852-5.
2009: Philip J Kingsley; Lawrence J Marnett
Analysis of endocannabinoids, their congeners and COX-2 metabolites.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(26):2746-54.
2009: Jeffery J Prusakiewicz; Kelsey C Duggan; Carol A Rouzer; Lawrence J Marnett
Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid.
Biochemistry 2009;48(31):7353-5.
2009: Robert L Eoff; Jennifer B Stafford; Jozsef Szekely; Carmelo J Rizzo; Martin Egli; F Peter Guengerich; Lawrence J Marnett
Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct.
Biochemistry 2009;48(30):7079-88.
2009: Victor P Ghidu; Ioanna Ntai; Jingqi Wang; Aaron T Jacobs; Lawrence J Marnett; Brian O Bachmann; Gary A Sulikowski
Combined chemical and biosynthetic route to access a new apoptolidin congener.
Organic letters 2009;11(14):3032-4.
2009: Matthew J Walters; Anna L Blobaum; Philip J Kingsley; Andrew S Felts; Gary A Sulikowski; Lawrence J Marnett
The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives.
Bioorganic & medicinal chemistry letters 2009;19(12):3271-4.
2009: Mary E Konkle; Tatiana Y Hargrove; Yuliya Y Kleshchenko; Jens P von Kries; Whitney Ridenour; Md Jashim Uddin; Richard M Caprioli; Lawrence J Marnett; W David Nes; Fernando Villalta; Michael R Waterman; Galina I Lepesheva
Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.
Journal of medicinal chemistry 2009;52(9):2846-53.
2009: Aaron T Jacobs; Lawrence J Marnett
HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins.
The Journal of biological chemistry 2009;284(14):9176-83.
2009: Lawrence J Marnett
Mechanisms of cyclooxygenase-2 inhibition and cardiovascular side effects: the plot thickens.
Cancer prevention research (Philadelphia, Pa.) 2009;2(4):288-90.
2009: Carol A Rouzer; Lawrence J Marnett
Cyclooxygenases: structural and functional insights.
Journal of lipid research 2009;50 Suppl():S29-34.
2009: Charles G Knutson; Emily H Rubinson; Dapo Akingbade; Carolyn S Anderson; Donald F Stec; Katya V Petrova; Ivan D Kozekov; F Peter Guengerich; Carmelo J Rizzo; Lawrence J Marnett
Oxidation and glycolytic cleavage of etheno and propano DNA base adducts.
Biochemistry 2009;48(4):800-9.
2009: Xiaofei Sun; Haibin Wang; Masaru Okabe; Ken Mackie; Philip J Kingsley; Lawrence J Marnett; Benjamin F Cravatt; Sudhansu K Dey
Genetic loss of Faah compromises male fertility in mice.
Biology of reproduction 2009;80(2):235-42.
2009: Jennifer B Stafford; Robert L Eoff; Albena Kozekova; Carmelo J Rizzo; F Peter Guengerich; Lawrence J Marnett
Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one.
Biochemistry 2009;48(2):471-80.
2009: Keri A Tallman; Andrew Vila; Ned A Porter; Lawrence J Marnett
Measuring electrophile stress.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2009;Chapter 17():Unit17.11.
2009: Lawrence J Marnett
The COXIB experience: a look in the rearview mirror.
Annual review of pharmacology and toxicology 2009;49():265-90.
2008: Md Jashim Uddin; Lawrence J Marnett
Synthesis of 5- and 6-carboxy-X-rhodamines.
Organic letters 2008;10(21):4799-801.
2008: Christopher D Toscano; Philip J Kingsley; Lawrence J Marnett; Francesca Bosetti
NMDA-induced seizure intensity is enhanced in COX-2 deficient mice.
Neurotoxicology 2008;29(6):1114-20.
2008: Lawrence J Marnett
Biochemistry: Divergence from the superfamily.
Nature 2008;455(7211):300-1.
2008: Laurie A VanderVeen; Thomas Harris; Linda Jen-Jacobson; Lawrence J Marnett
Formation of DNA-protein cross-links between gamma-hydroxypropanodeoxyguanosine and EcoRI.
Chemical research in toxicology 2008;21(9):1733-8.
2008: Troy B Adams; C Lucas Gavin; S V Taylor; William J Waddell; Samuel M Cohen; Victor J Feron; J Goodman; I M C M Rietjens; Lawrence J Marnett; Philip S Portoghese; Robert L Smith
The FEMA GRAS assessment of alpha,beta-unsaturated aldehydes and related substances used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(9):2935-67.
2008: Andrew S Felts; Brianna S Siegel; Shiu M Young; Christopher W Moth; Terry P Lybrand; Andrew J Dannenberg; Lawrence J Marnett; Kotha Subbaramaiah
Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition.
Journal of medicinal chemistry 2008;51(16):4911-9.
2008: Yazhen Wang; Sarah K Musser; Sam Saleh; Lawrence J Marnett; Martin Egli; Michael P Stone
Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IV.
Biochemistry 2008;47(28):7322-34.
2008: Victor P Ghidu; Jingqi Wang; Bin Wu; Qingsong Liu; Aaron Jacobs; Lawrence J Marnett; Gary A Sulikowski
Synthesis and evaluation of the cytotoxicity of apoptolidinones A and D.
The Journal of organic chemistry 2008;73(13):4949-55.
2008: Charles G Knutson; Paul L Skipper; Rosa G Liberman; Steven R Tannenbaum; Lawrence J Marnett
Monitoring in vivo metabolism and elimination of the endogenous DNA adduct, M1dG {3-(2-deoxy-beta-D-erythro-pentofuranosyl)pyrimido[1,2-alpha]purin-10(3H)-one}, by accelerator mass spectrometry.
Chemical research in toxicology 2008;21(6):1290-4.
2008: Manju Bala; Cindy N Chin; Asha T Logan; Taneem Amin; Lawrence J Marnett; Olivier Boutaud; John A Oates
Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase.
Biochemical pharmacology 2008;75(7):1472-81.
2008: Carol A Rouzer; Lawrence J Marnett
Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoids.
The Journal of biological chemistry 2008;283(13):8065-9.
2008: Melissa V Turman; Philip J Kingsley; Carol A Rouzer; Benjamin F Cravatt; Lawrence J Marnett
Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.
Biochemistry 2008;47(12):3917-25.
2008: Joseph Szekely; Carmelo J Rizzo; Lawrence J Marnett
Chemical properties of oxopropenyl adducts of purine and pyrimidine nucleosides and their reactivity toward amino acid cross-link formation.
Journal of the American Chemical Society 2008;130(7):2195-201.
2008: Andrew Vila; Keri A Tallman; Aaron T Jacobs; Daniel C Liebler; Ned A Porter; Lawrence J Marnett
Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives.
Chemical research in toxicology 2008;21(2):432-44.
2008: Jozsef Szekely; Hao Wang; Katherine M Peplowski; Charles G Knutson; Lawrence J Marnett; Carmelo J Rizzo
"One-pot" syntheses of malondialdehyde adducts of nucleosides.
Nucleosides, nucleotides & nucleic acids 2008;27(2):103-9.
2008: Jennifer B Stafford; Lawrence J Marnett
Prostaglandin E2 inhibits tumor necrosis factor-alpha RNA through PKA type I.
Biochemical and biophysical research communications 2008;366(1):104-9.
2007: Charles G Knutson; Hao Wang; Carmelo J Rizzo; Lawrence J Marnett
Metabolism and elimination of the endogenous DNA adduct, 3-(2-deoxy-beta-D-erythropentofuranosyl)-pyrimido[1,2-alpha]purine-10(3H)-one, in the rat.
The Journal of biological chemistry 2007;282(50):36257-64.
2007: Aaron T Jacobs; Lawrence J Marnett
Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL.
The Journal of biological chemistry 2007;282(46):33412-20.
2007: Alexandra Druckova; Raymond L Mernaugh; Amy-Joan L Ham; Lawrence J Marnett
Identification of the protein targets of the reactive metabolite of teucrin A in vivo in the rat.
Chemical research in toxicology 2007;20(10):1393-408.
2007: Christine A Harman; Melissa V Turman; Kevin R Kozak; Lawrence J Marnett; William L Smith; R Michael Garavito
Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides.
The Journal of biological chemistry 2007;282(38):28096-105.
2007: Lawrence J Marnett
AuthorChoice: a great way to get your papers read.
Chemical research in toxicology 2007;20(9):1235-6.
2007: Andrew Vila; Anja Rosengarth; Daniele Piomelli; Benjamin F Cravatt; Lawrence J Marnett
Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase.
Biochemistry 2007;46(33):9578-85.
2007: Myungsoo Joo; Minjae Kwon; Ruxana T Sadikot; Philip J Kingsley; Lawrence J Marnett; Timothy S Blackwell; R Stokes Peebles; Yoshihiro Urade; John W Christman
Induction and function of lipocalin prostaglandin D synthase in host immunity.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2565-75.
2007: Jeffery J Prusakiewicz; Melissa V Turman; Andrew Vila; Heather L Ball; Ahmad H Al-Mestarihi; Vincenzo Di Marzo; Lawrence J Marnett
Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.
Archives of biochemistry and biophysics 2007;464(2):260-8.
2007: Yazhen Wang; Nathalie Schnetz-Boutaud; Sam Saleh; Lawrence J Marnett; Michael P Stone
Bulge migration of the malondialdehyde OPdG DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Chemical research in toxicology 2007;20(8):1200-10.
2007: Andrew S Felts; Chuan Ji; Jennifer B Stafford; Brenda C Crews; Philip J Kingsley; Carol A Rouzer; Mary Kay Washington; Kotha Subbaramaiah; Brianna S Siegel; Shiu M Young; Andrew J Dannenberg; Lawrence J Marnett
Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology.
ACS chemical biology 2007;2(7):479-83.
2007: Aaron T Jacobs; Lawrence J Marnett
The future of toxicology--wrap up.
Chemical research in toxicology 2007;20(7):983-5.
2007: Anna L Blobaum; Lawrence J Marnett
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.
The Journal of biological chemistry 2007;282(22):16379-90.
2007: Carol A Rouzer; Pavlina T Ivanova; Mark O Byrne; H Alex Brown; Lawrence J Marnett
Lipid profiling reveals glycerophospholipid remodeling in zymosan-stimulated macrophages.
Biochemistry 2007;46(20):6026-42.
2007: Anna L Blobaum; Lawrence J Marnett
Structural and functional basis of cyclooxygenase inhibition.
Journal of medicinal chemistry 2007;50(7):1425-41.
2007: Andres Trostchansky; Valerie B O'Donnell; Douglas C Goodwin; Lisa M Landino; Lawrence J Marnett; Rafael Radi; Homero Rubbo
Interactions between nitric oxide and peroxynitrite during prostaglandin endoperoxide H synthase-1 catalysis: a free radical mechanism of inactivation.
Free radical biology & medicine 2007;42(7):1029-38.
2007: Charles G Knutson; Dapo Akingbade; Brenda C Crews; Markus Voehler; Donald F Stec; Lawrence J Marnett
Metabolism in vitro and in vivo of the DNA base adduct, M1G.
Chemical research in toxicology 2007;20(3):550-7.
2007: Haibin Wang; Huirong Xie; Xiaofei Sun; Philip J Kingsley; Lawrence J Marnett; Benjamin F Cravatt; Sudhansu K Dey
Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation.
Prostaglandins & other lipid mediators 2007;83(1-2):62-74.
2007: Troy B Adams; M M McGowen; M C Williams; Samuel M Cohen; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Philip S Portoghese; Robert L Smith; William J Waddell
The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(2):171-201.
2007: Craig W Lindsley; David Weaver; Carrie Jones; Lawrence J Marnett; P Jeffrey Conn
Preclinical drug discovery research and training at Vanderbilt.
ACS chemical biology 2007;2(1):17-20.
2007: Ying Yu; Jinjin Fan; Yiqun Hui; Carol A Rouzer; Lawrence J Marnett; Andres J P Klein-Szanto; garret fitzgerald; Colin D Funk
Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality.
The Journal of biological chemistry 2007;282(2):1498-506.
2007: Philip J Kingsley; Lawrence J Marnett
LC-MS-MS analysis of neutral eicosanoids.
Methods in enzymology 2007;433():91-112.
2006: Peter B Anning; Barbara Coles; Jonathan Morton; Haibin Wang; Jashim Uddin; Jason D Morrow; Sudhansu K Dey; Lawrence J Marnett; Valerie B O'Donnell
Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors.
Blood 2006;108(13):4059-62.
2006: Carol A Rouzer; Pavlina T Ivanova; Mark O Byrne; Stephen B Milne; Lawrence J Marnett; H Alex Brown
Lipid profiling reveals arachidonate deficiency in RAW264.7 cells: Structural and functional implications.
Biochemistry 2006;45(49):14795-808.
2006: Hao Wang; Ivan D Kozekov; Albena Kozekova; Pamela J Tamura; Lawrence J Marnett; Thomas Harris; Carmelo J Rizzo
Site-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a postsynthetic modification strategy.
Chemical research in toxicology 2006;19(11):1467-74.
2006: Zhaohui Feng; Wenwei Hu; Lawrence J Marnett; Moon-shong Tang
Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair.
Mutation research 2006;601(1-2):125-36.
2006: Alexandra Druckova; Lawrence J Marnett
Characterization of the amino acid adducts of the enedial derivative of teucrin A.
Chemical research in toxicology 2006;19(10):1330-40.
2006: Carol A Rouzer; Susanne Tranguch; Haibin Wang; Hao Zhang; Sudhansu K Dey; Lawrence J Marnett
Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2.
The Biochemical journal 2006;399(1):91-9.
2006: Haibin Wang; Huirong Xie; Yong Guo; Hao Zhang; Toshifumi Takahashi; Philip J Kingsley; Lawrence J Marnett; Sanjoy K Das; Benjamin F Cravatt; Sudhansu K Dey
Fatty acid amide hydrolase deficiency limits early pregnancy events.
The Journal of clinical investigation 2006;116(8):2122-31.
2006: Michael B Otteneder; Charles G Knutson; J Scott Daniels; Muhammed F Hashim; Brenda C Crews; Rory P Remmel; Hao Wang; Carmelo J Rizzo; Lawrence J Marnett
In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6665-9.
2006: James D West; Lawrence J Marnett
Endogenous reactive intermediates as modulators of cell signaling and cell death.
Chemical research in toxicology 2006;19(2):173-94.
2006: Gladson Muthian; Himanshu P Raikwar; Caroline Johnson; Rajasingh Johnson; Amit Kalgutkar; Lawrence J Marnett; John Bright
COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis.
Journal of clinical immunology 2006;26(1):73-85.
2005: Amit S Kalgutkar; Brenda C Crews; Sam Saleh; Daniel Prudhomme; Lawrence J Marnett
Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors.
Bioorganic & medicinal chemistry 2005;13(24):6810-22.
2005: Carol A Rouzer; Lawrence J Marnett
Structural and functional differences between cyclooxygenases: fatty acid oxygenases with a critical role in cell signaling.
Biochemical and biophysical research communications 2005;338(1):34-44.
2005: James D West; Lawrence J Marnett
Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal.
Chemical research in toxicology 2005;18(11):1642-53.
2005: Marja D Van Sickle; Marnie Duncan; Philip J Kingsley; Abdeslam Mouihate; Paolo Urbani; Ken Mackie; Nephi Stella; Alexandros Makriyannis; Daniele Piomelli; Joseph S Davison; Lawrence J Marnett; Vincenzo Di Marzo; Quentin J Pittman; Kamala D Patel; Keith Sharkey
Identification and functional characterization of brainstem cannabinoid CB2 receptors.
Science (New York, N.Y.) 2005;310(5746):329-32.
2005: Miriam Sander; Jean Cadet; Daniel A Casciano; Sheila M Galloway; Lawrence J Marnett; Raymond F Novak; syril director pettit; R Julian Preston; Julie A Skare; Gary M Williams; Bennett Van Houten; B Bhaskar Gollapudi
Proceedings of a workshop on DNA adducts: biological significance and applications to risk assessment Washington, DC, April 13-14, 2004.
Toxicology and applied pharmacology 2005;208(1):1-20.
2005: Philip J Kingsley; Carol A Rouzer; Samir Saleh; Lawrence J Marnett
Simultaneous analysis of prostaglandin glyceryl esters and prostaglandins by electrospray tandem mass spectrometry.
Analytical biochemistry 2005;343(2):203-11.
2005: Troy B Adams; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Philip S Portoghese; Robert L Smith; William J Waddell; Bernard M Wagner
The FEMA GRAS assessment of hydroxy- and alkoxy-substituted benzyl derivatives used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1241-71.
2005: Troy B Adams; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Philip S Portoghese; Robert L Smith; William J Waddell; Bernard M Wagner
The FEMA GRAS assessment of benzyl derivatives used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1207-40.
2005: Troy B Adams; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Philip S Portoghese; Robert L Smith; William J Waddell; Bernard M Wagner
The FEMA GRAS assessment of phenethyl alcohol, aldehyde, acid, and related acetals and esters used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1179-206.
2005: Robert L Smith; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Philip S Portoghese; William J Waddell; Bernard M Wagner; Troy B Adams
Criteria for the safety evaluation of flavoring substances. The Expert Panel of the Flavor and Extract Manufacturers Association.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1141-77.
2005: Michael E Burleigh; Vladimir R Babaev; Mayur B Patel; Brenda C Crews; Rory P Remmel; Jason D Morrow; John A Oates; Lawrence J Marnett; Sergio Fazio; MacRae F Linton
Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice.
Biochemical pharmacology 2005;70(3):334-42.
2005: Carol A Rouzer; Lawrence J Marnett
Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus.
The Journal of biological chemistry 2005;280(29):26690-700.
2005: Yong Guo; Haibin Wang; Yasuo Okamoto; Natsuo Ueda; Philip J Kingsley; Lawrence J Marnett; Harald H O Schmid; Sanjoy K Das; Sudhansu K Dey
N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation.
The Journal of biological chemistry 2005;280(25):23429-32.
2005: Christopher W Moth; Jeffery J Prusakiewicz; Lawrence J Marnett; Terry P Lybrand
Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1.
Journal of medicinal chemistry 2005;48(10):3613-20.
2005: Carol A Rouzer; Aaron T Jacobs; Chetan S Nirodi; Philip J Kingsley; Jason D Morrow; Lawrence J Marnett
RAW264.7 cells lack prostaglandin-dependent autoregulation of tumor necrosis factor-alpha secretion.
Journal of lipid research 2005;46(5):1027-37.
2005: James D West; Chuan Ji; Lawrence J Marnett
Modulation of DNA fragmentation factor 40 nuclease activity by poly(ADP-ribose) polymerase-1.
The Journal of biological chemistry 2005;280(15):15141-7.
2005: Laurie A VanderVeen; Alexandra Druckova; James N Riggins; Jennifer L Sorrells; F Peter Guengerich; Lawrence J Marnett
Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct.
Biochemistry 2005;44(13):5024-33.
2005: Renier Vélez-Cruz; James N Riggins; J Scott Daniels; Hongliang Cai; F Peter Guengerich; Lawrence J Marnett; Neil Osheroff
Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.
Biochemistry 2005;44(10):3972-81.
2005: Maria B Kadiiska; Beth C Gladen; Donna D Baird; LB Graham; Carol Parker; Bruce N Ames; S Basu; garret fitzgerald; J A Lawson; Lawrence J Marnett; J D Morrow; D M Murray; J Plastaras; L J Roberts; J Rokach; Mark K Shigenaga; J Sun; Patrick B Walter; Kenneth B Tomer; JC Barrett; Ronald P Mason
Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning.
Free radical biology & medicine 2005;38(6):711-8.
2005: M B Kadiiska; B C Gladen; D D Baird; D Germolec; L B Graham; Carol Parker; A Nyska; J T Wachsman; B N Ames; S Basu; N Brot; garret fitzgerald; R A Floyd; M George; J W Heinecke; G E Hatch; Kenneth Hensley; J A Lawson; Lawrence J Marnett; J D Morrow; D M Murray; J Plastaras; L J Roberts; J Rokach; M K Shigenaga; R S Sohal; J Sun; R R Tice; D H Van Thiel; D Wellner; Patrick B Walter; K B Tomer; R P Mason; J C Barrett
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?
Free radical biology & medicine 2005;38(6):698-710.
2005: Robert L Smith; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Philip S Portoghese; William J Waddell; Bernard M Wagner; RL Hall; N A Higley; C Lucas-Gavin; Troy B Adams
A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(3):345-63.
2005: Aaron N Hata; Terry P Lybrand; Lawrence J Marnett; Richard M Breyer
Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2.
Molecular pharmacology 2005;67(3):640-7.
2005: Stephen Clark; Peter B Anning; Marcus J Coffey; Andrew G Roberts; Lawrence J Marnett; Valerie B O'Donnell
Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover.
The Biochemical journal 2005;385(Pt 3):815-21.
2004: Jeffery J Prusakiewicz; Andrew S Felts; Bonnie S Mackenzie; Lawrence J Marnett
Molecular basis of the time-dependent inhibition of cyclooxygenases by indomethacin.
Biochemistry 2004;43(49):15439-45.
2004: Haibin Wang; Yong Guo; Dingzhi Wang; Philip J Kingsley; Lawrence J Marnett; Sanjoy K Das; Raymond DuBois; Sudhansu K Dey
Aberrant cannabinoid signaling impairs oviductal transport of embryos.
Nature medicine 2004;10(10):1074-80.
2004: Muhammed F Hashim; James N Riggins; Nathalie Schnetz-Boutaud; Markus Voehler; Michael P Stone; Lawrence J Marnett
In vitro bypass of malondialdehyde-deoxyguanosine adducts: differential base selection during extension by the Klenow fragment of DNA polymerase I is the critical determinant of replication outcome.
Biochemistry 2004;43(37):11828-35.
2004: James N Riggins; Derek A Pratt; Markus Voehler; J Scott Daniels; Lawrence J Marnett
Kinetics and mechanism of the general-acid-catalyzed ring-closure of the malondialdehyde-DNA adduct, N2-(3-oxo-1-propenyl)deoxyguanosine (N2OPdG-), to 3-(2'-Deoxy-beta-D-erythro-pentofuranosyl)pyrimido[1,2-alpha]purin- 10(3H)-one (M1dG).
Journal of the American Chemical Society 2004;126(34):10571-81.
2004: Carol A Rouzer; Philip J Kingsley; Haibin Wang; Hao Zhang; Jason D Morrow; Sudhansu K Dey; Lawrence J Marnett
Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages.
The Journal of biological chemistry 2004;279(33):34256-68.
2004: James N Riggins; J Scott Daniels; Carol A Rouzer; Lawrence J Marnett
Kinetic and thermodynamic analysis of the hydrolytic ring-opening of the malondialdehyde-deoxyguanosine adduct, 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)- pyrimido[1,2-alpha]purin-10(3H)-one.
Journal of the American Chemical Society 2004;126(26):8237-43.
2004: Susan D Cline; James N Riggins; Silvia Tornaletti; Lawrence J Marnett; Philip C Hanawalt
Malondialdehyde adducts in DNA arrest transcription by T7 RNA polymerase and mammalian RNA polymerase II.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(19):7275-80.
2004: Robert L Smith; Troy B Adams; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; RL Hall; Lawrence J Marnett; Philip S Portoghese; William J Waddell; Bernard M Wagner
Safety evaluation of natural flavour complexes.
Toxicology letters 2004;149(1-3):197-207.
2004: James D West; Chuan Ji; Stephen T Duncan; Venkataraman Amarnath; Claus Schneider; Carmelo J Rizzo; Alan R Brash; Lawrence J Marnett
Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation.
Chemical research in toxicology 2004;17(4):453-62.
2004: Chaitanya S Nirodi; Brenda C Crews; Kevin R Kozak; Jason D Morrow; Lawrence J Marnett
The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1840-5.
2004: Hao Wang; Lawrence J Marnett; Thomas Harris; Carmelo J Rizzo
A novel synthesis of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine.
Chemical research in toxicology 2004;17(2):144-9.
2004: Troy B Adams; Samuel M Cohen; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Philip S Portoghese; Robert L Smith; William J Waddell; Bernard M Wagner
The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(2):157-85.
2004: Kevin R Kozak; Jeffery J Prusakiewicz; Lawrence J Marnett
Oxidative metabolism of endocannabinoids by COX-2.
Current pharmaceutical design 2004;10(6):659-67.
2004: Anne-Mette Hoberg; Michael Otteneder; Lawrence J Marnett; Henrik E Poulsen
Measurement of the malondialdehyde-2'-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS 2004;39(1):38-42.
2004: Rory P Remmel; Brenda C Crews; Kevin R Kozak; Amit S Kalgutkar; Lawrence J Marnett; Amit S Algutkar
Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(1):113-22.
2003: Laurie A VanderVeen; Muhammed F Hashim; Yu Shyr; Lawrence J Marnett
Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14247-52.
2003: Scott W Rowlinson; James R Kiefer; Jeffery J Prusakiewicz; Jennifer L Pawlitz; Kevin R Kozak; Amit S Kalgutkar; William C Stallings; Ravi Kurumbail; Lawrence J Marnett
A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.
The Journal of biological chemistry 2003;278(46):45763-9.
2003: Laura J Niedernhofer; J Scott Daniels; Carol A Rouzer; Rachel E Greene; Lawrence J Marnett
Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells.
The Journal of biological chemistry 2003;278(33):31426-33.
2003: Kevin R Kozak; Jeffery J Prusakiewicz; Scott W Rowlinson; Daniel R Prudhomme; Lawrence J Marnett
Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide.
Biochemistry 2003;42(30):9041-9.
2003: Zheyong Yu; Claus Schneider; William E Boeglin; Lawrence J Marnett; Alan R Brash
The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9162-7.
2003: Carol A Rouzer; Lawrence J Marnett
Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases.
Chemical reviews 2003;103(6):2239-304.
2003: Cândida F Pereira; Judith T M L Paridaen; Karla Rutten; Marleen C D G Huigen; Marja van de Bovenkamp; Jeena Middel; Nancy Beerens; Ben Berkhout; Rob Schuurman; Lawrence J Marnett; Jan Verhoef; Hans S L M Nottet
Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication.
Antiviral research 2003;58(3):253-63.
2003: Michael Otteneder; Markus Voehler; J Scott Daniels; Lawrence J Marnett
Development of a method for determination of the malondialdehyde-deoxyguanosine adduct in urine using liquid chromatography-tandem mass spectrometry.
Analytical biochemistry 2003;315(2):147-51.
2003: Philip J Kingsley; Lawrence J Marnett
Analysis of endocannabinoids by Ag+ coordination tandem mass spectrometry.
Analytical biochemistry 2003;314(1):8-15.
2003: Lawrence J Marnett; James N Riggins; James D West
Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein.
The Journal of clinical investigation 2003;111(5):583-93.
2003: David M Aronoff; Olivier Boutaud; Lawrence J Marnett; John A Oates
Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.
The Journal of pharmacology and experimental therapeutics 2003;304(2):589-95.
2003: David M Aronoff; Olivier Boutaud; Lawrence J Marnett; John A Oates
Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.
Advances in experimental medicine and biology 2003;525():125-8.
2003: G Phillip Hochgesang; Jennifer F Nemeth-Cawley; Scott W Rowlinson; Richard M Caprioli; Lawrence J Marnett
Functional analysis of the molecular determinants of cyclooxygenase-2 acetylation by 2-acetoxyphenylhept-2-ynyl sulfide.
Archives of biochemistry and biophysics 2003;409(1):127-33.
2002: Lawrence J Marnett
Oxy radicals, lipid peroxidation and DNA damage.
Toxicology 2002;181-182():219-22.
2002: Kevin R Kozak; Brenda C Crews; Jason D Morrow; Lee-Ho Wang; Y Henry Ma; Rolf Weinander; Per-Johan Jakobsson; Lawrence J Marnett
Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides.
The Journal of biological chemistry 2002;277(47):44877-85.
2002: Carol A Rouzer; Kebreab Ghebreselasie; Lawrence J Marnett
Chemical stability of 2-arachidonylglycerol under biological conditions.
Chemistry and physics of lipids 2002;119(1-2):69-82.
2002: Jeffery J Prusakiewicz; Philip J Kingsley; Kevin R Kozak; Lawrence J Marnett
Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2.
Biochemical and biophysical research communications 2002;296(3):612-7.
2002: John S Moody; Lawrence J Marnett
Kinetics of inhibition of leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid.
Biochemistry 2002;41(32):10297-303.
2002: Lawrence J Marnett
Recent developments in cyclooxygenase inhibition.
Prostaglandins & other lipid mediators 2002;68-69():153-64.
2002: Sergei L Timofeevski; Jeffery J Prusakiewicz; Carol A Rouzer; Lawrence J Marnett
Isoform-selective interaction of cyclooxygenase-2 with indomethacin amides studied by real-time fluorescence, inhibition kinetics, and site-directed mutagenesis.
Biochemistry 2002;41(30):9654-62.
2002: Robert L Smith; Troy B Adams; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Philip S Portoghese; William J Waddell; Bernard M Wagner; Adrianne E Rogers; John Caldwell; IG Sipes
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(7):851-70.
2002: Kevin R Kozak; Rajnish A Gupta; John S Moody; Chuan Ji; William E Boeglin; Raymond DuBois; Alan R Brash; Lawrence J Marnett
15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist.
The Journal of biological chemistry 2002;277(26):23278-86.
2002: Olivier Boutaud; David M Aronoff; Jacob H Richardson; Lawrence J Marnett; John A Oates
Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):7130-5.
2002: Kevin R Kozak; Jeffery J Prusakiewicz; Scott W Rowlinson; Lawrence J Marnett
Enantiospecific, selective cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(9):1315-8.
2002: Michael E Burleigh; Vladimir R Babaev; John A Oates; Raymond C Harris; Shiva Gautam; Denis Riendeau; Lawrence J Marnett; Jason D Morrow; Sergio Fazio; MacRae F Linton
Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice.
Circulation 2002;105(15):1816-23.
2002: John P Plastaras; Peter C Dedon; Lawrence J Marnett
Effects of DNA structure on oxopropenylation by the endogenous mutagens malondialdehyde and base propenal.
Biochemistry 2002;41(15):5033-42.
2002: SEKHAR KONJETI; Douglas R Spitz; Stephanie Harris; Trung T Nguyen; Michael J (Michael) Meredith; Jeffrey T Holt; David Gius; Lawrence J Marnett; Marshall Summar; Michael L Freeman; David Guis
Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.
Free radical biology & medicine 2002;32(7):650-62.
2002: Troy B Adams; John Doull; Victor J Feron; Jay I Goodman; Lawrence J Marnett; Ian C Munro; Paul M Newberne; Philip S Portoghese; Robert L Smith; William J Waddell; Bernard M Wagner
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. Flavor and Extract Manufacturers Association.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(4):429-51.
2002: Michael Otteneder; John P Plastaras; Lawrence J Marnett
Reaction of malondialdehyde-DNA adducts with hydrazines-development of a facile assay for quantification of malondialdehyde equivalents in DNA.
Chemical research in toxicology 2002;15(3):312-8.
2002: Chiara Leuratti; Mark A Watson; Eliot J Deag; Ailsa Welch; Rajinder Singh; Elke Gottschalg; Lawrence J Marnett; Wendy S Atkin; Nicholas E Day; David E G Shuker; Sheila A Bingham
Detection of malondialdehyde DNA adducts in human colorectal mucosa: relationship with diet and the presence of adenomas.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(3):267-73.
2002: Amit S Kalgutkar; Scott W Rowlinson; Brenda C Crews; Lawrence J Marnett
Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(4):521-4.
2002: Kevin R Kozak; Lawrence J Marnett
Oxidative metabolism of endocannabinoids.
Prostaglandins, leukotrienes, and essential fatty acids 2002;66(2-3):211-20.
2002: Jason P Weisenseel; G Ramachandra Reddy; Lawrence J Marnett; Michael P Stone
Structure of the 1,N(2)-propanodeoxyguanosine adduct in a three-base DNA hairpin loop derived from a palindrome in the Salmonella typhimurium hisD3052 gene.
Chemical research in toxicology 2002;15(2):140-52.
2002: Jason P Weisenseel; G Ramachandra Reddy; Lawrence J Marnett; Michael P Stone
Structure of an oligodeoxynucleotide containing a 1,N(2)-propanodeoxyguanosine adduct positioned in a palindrome derived from the Salmonella typhimurium hisD3052 gene: Hoogsteen pairing at pH 5.2.
Chemical research in toxicology 2002;15(2):127-39.
2002: Claus Schneider; William E Boeglin; Jeffery J Prusakiewicz; Scott W Rowlinson; Lawrence J Marnett; Nigulas Samel; Alan R Brash
Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349.
The Journal of biological chemistry 2002;277(1):478-85.
2002: James K Gierse; Ravi Kurumbail; Mark Walker; Bill Hood; Joseph B Monahan; Jennifer Pawlitz; Rick Stegeman; Anna Stevens; Jim Kiefer; Carol M Koboldt; Kirby Moreland; Scott W Rowlinson; Lawrence J Marnett; Jennifer Pierce; Jeff Carter; John J Talley; Peter C Isakson; Karen Seibert
Mechanism of inhibition of novel COX-2 inhibitors.
Advances in experimental medicine and biology 2002;507():365-9.
2002: Lawrence J Marnett; Raymond DuBois
COX-2: a target for colon cancer prevention.
Annual review of pharmacology and toxicology 2002;42():55-80.
2001: Nathalie Schnetz-Boutaud; Sam Saleh; Lawrence J Marnett; Michael P Stone
The exocyclic 1,N2-deoxyguanosine pyrimidopurinone M1G is a chemically stable DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Biochemistry 2001;40(51):15638-49.
2001: Ravi Kurumbail; James R Kiefer; Lawrence J Marnett
Cyclooxygenase enzymes: catalysis and inhibition.
Current opinion in structural biology 2001;11(6):752-60.
2001: James N Riggins; Lawrence J Marnett
Mutagenicity of the malondialdehyde oligomerization products 2-(3'-oxo-1'-propenyl)-malondialdehyde and 2,4-dihydroxymethylene-3-(2,2-dimethoxyethyl)glutaraldehyde in Salmonella.
Mutation research 2001;497(1-2):153-7.
2001: Kevin R Kozak; Brenda C Crews; Jennifer Panizzi; Hsin-Hsiung Tai; Jason D Morrow; Lawrence J Marnett
Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo.
The Journal of biological chemistry 2001;276(40):36993-8.
2001: Ricky A Sharma; Andreas J Gescher; JP Plastaras; Chiara Leuratti; Rajinder Singh; Barbara Gallacher-Horley; E Offord; Lawrence J Marnett; William P Steward; S M Plummer
Cyclooxygenase-2, malondialdehyde and pyrimidopurinone adducts of deoxyguanosine in human colon cells.
Carcinogenesis 2001;22(9):1557-60.
2001: Kevin R Kozak; Jeffery J Prusakiewicz; Scott W Rowlinson; Claus Schneider; Lawrence J Marnett
Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol.
The Journal of biological chemistry 2001;276(32):30072-7.
2001: Chuan Ji; Venkataraman Amarnath; Jennifer A Pietenpol; Lawrence J Marnett
4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release.
Chemical research in toxicology 2001;14(8):1090-6.
2001: Rajinder Singh; Chiara Leuratti; S Josyula; MA Sipowicz; Bhalchandra A Diwan; Kazimierz S Kasprzak; Herman A J Schut; Lawrence J Marnett; Lucy M Anderson; David E G Shuker
Lobe-specific increases in malondialdehyde DNA adduct formation in the livers of mice following infection with Helicobacter hepaticus.
Carcinogenesis 2001;22(8):1281-7.
2001: Ricky A Sharma; H R McLelland; KA Hill; Christopher R Ireson; Stephanie A Euden; Margaret M Manson; Munir Pirmohamed; Lawrence J Marnett; Andreas J Gescher; William P Steward
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):1894-900.
2001: Olivier Boutaud; Cynthia J Brame; Pierre Chaurand; Junyu Li; Scott W Rowlinson; Brenda C Crews; Chuan Ji; Lawrence J Marnett; Richard M Caprioli; L Jackson Roberts; John A Oates
Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid.
Biochemistry 2001;40(23):6948-55.
2001: Chuan Ji; Kevin R Kozak; Lawrence J Marnett
IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal.
The Journal of biological chemistry 2001;276(21):18223-8.
2001: Nathalie Schnetz-Boutaud; M C Chapeau; Lawrence J Marnett
Enzymatic synthesis of M(1)G-deoxyribose.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2001;Chapter 1():Unit1.2.
2001: Ricky A Sharma; Christopher R Ireson; Richard D Verschoyle; KA Hill; Marion L Williams; Chiara Leuratti; Margaret M Manson; Lawrence J Marnett; William P Steward; Andreas J Gescher
Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1452-8.
2001: SP Fink; Lawrence J Marnett
The relative contribution of adduct blockage and DNA repair on template utilization during replication of 1,N2-propanodeoxyguanosine and pyrimido.
Mutation research 2001;485(3):209-18.
2001: Simon M Everett; R Singh; C Leuratti; K L M White; PM Neville; D Greenwood; Lawrence J Marnett; Chris J Schorah; David Forman; David E G Shuker; A T R Axon
Levels of malondialdehyde-deoxyguanosine in the gastric mucosa: relationship with lipid peroxidation, ascorbic acid, and Helicobacter pylori.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(4):369-76.
2001: Theodore L DeWeese; A M Hruszkewycz; Lawrence J Marnett
Oxidative stress in chemoprevention trials.
Urology 2001;57(4 Suppl 1):137-40.
2001: Lawrence J Marnett; John P Plastaras
Endogenous DNA damage and mutation.
Trends in genetics : TIG 2001;17(4):214-21.
2001: Laurie A VanderVeen; Muhammed F Hashim; Lubomir V Nechev; Thomas Harris; Constance M Harris; Lawrence J Marnett
Evaluation of the mutagenic potential of the principal DNA adduct of acrolein.
The Journal of biological chemistry 2001;276(12):9066-70.
2001: J F Nemeth; G P Hochgesang; Lawrence J Marnett; Richard M Caprioli; G P Hochensang
Characterization of the glycosylation sites in cyclooxygenase-2 using mass spectrometry.
Biochemistry 2001;40(10):3109-16.
2001: John S Moody; Kevin R Kozak; Chuan Ji; Lawrence J Marnett
Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase.
Biochemistry 2001;40(4):861-6.
2001: Nathalie Schnetz-Boutaud; Sam Saleh; Lawrence J Marnett; Michael P Stone
Structure of the malondialdehyde deoxyguanosine adduct M1G when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Advances in experimental medicine and biology 2001;500():513-6.
2001: Olivier Boutaud; Junyu Li; Pierre Chaurand; Cynthia J Brame; Lawrence J Marnett; L Jackson Roberts; John A Oates
Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins.
Advances in experimental medicine and biology 2001;500():133-7.
2000: Valerie B O'Donnell; Barbara Coles; Malcolm J Lewis; B C Crews; Lawrence J Marnett; Bruce Freeman
Catalytic consumption of nitric oxide by prostaglandin H synthase-1 regulates platelet function.
The Journal of biological chemistry 2000;275(49):38239-44.
2000: John P Plastaras; James N Riggins; Michael Otteneder; Lawrence J Marnett
Reactivity and mutagenicity of endogenous DNA oxopropenylating agents: base propenals, malondialdehyde, and N(epsilon)-oxopropenyllysine.
Chemical research in toxicology 2000;13(12):1235-42.
2000: Kevin R Kozak; Scott W Rowlinson; Lawrence J Marnett
Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.
The Journal of biological chemistry 2000;275(43):33744-9.
2000: Nathalie Schnetz-Boutaud; J Scott Daniels; Muhammed F Hashim; P Scholl; T Burrus; Lawrence J Marnett
Pyrimido[1,2-alpha]purin-10(3H)-one: a reactive electrophile in the genome.
Chemical research in toxicology 2000;13(10):967-70.
2000: Lawrence J Marnett
Cyclooxygenase mechanisms.
Current opinion in chemical biology 2000;4(5):545-52.
2000: Amit S Kalgutkar; A B Marnett; Brenda C Crews; Rory P Remmel; Lawrence J Marnett
Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.
Journal of medicinal chemistry 2000;43(15):2860-70.
2000: CA Lanzo; J Sutin; Scott W Rowlinson; John J Talley; Lawrence J Marnett
Fluorescence quenching analysis of the association and dissociation of a diarylheterocycle to cyclooxygenase-1 and cyclooxygenase-2: dynamic basis of cyclooxygenase-2 selectivity.
Biochemistry 2000;39(20):6228-34.
2000: Douglas C Goodwin; Scott W Rowlinson; Lawrence J Marnett
Substitution of tyrosine for the proximal histidine ligand to the heme of prostaglandin endoperoxide synthase 2: implications for the mechanism of cyclooxygenase activation and catalysis.
Biochemistry 2000;39(18):5422-32.
2000: Lawrence J Marnett; T L Wright; Brenda C Crews; Steven R Tannenbaum; Jason D Morrow
Regulation of prostaglandin biosynthesis by nitric oxide is revealed by targeted deletion of inducible nitric-oxide synthase.
The Journal of biological chemistry 2000;275(18):13427-30.
2000: James R Kiefer; Jennifer L Pawlitz; Kirby Moreland; Roderick A Stegeman; William F Hood; James K Gierse; Anna M Stevens; Douglas C Goodwin; Scott W Rowlinson; Lawrence J Marnett; William C Stallings; Ravi Kurumbail
Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature 2000;405(6782):97-101.
2000: John P Plastaras; F Peter Guengerich; D W Nebert; Lawrence J Marnett
Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde.
The Journal of biological chemistry 2000;275(16):11784-90.
2000: Scott W Rowlinson; Brenda C Crews; Douglas C Goodwin; Claus Schneider; James K Gierse; Lawrence J Marnett
Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete.
The Journal of biological chemistry 2000;275(9):6586-91.
2000: Lawrence J Marnett
Oxyradicals and DNA damage.
Carcinogenesis 2000;21(3):361-70.
2000: Nathalie Schnetz-Boutaud; H Mao; Michael P Stone; Lawrence J Marnett
Synthesis of oligonucleotides containing the alkali-labile pyrimidopurinone adduct, M(1)G.
Chemical research in toxicology 2000;13(2):90-5.
2000: Amit S Kalgutkar; Brenda C Crews; Scott W Rowlinson; A B Marnett; Kevin R Kozak; Rory P Remmel; Lawrence J Marnett
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):925-30.
2000: Lawrence J Marnett
Structure, function and inhibition of cyclo-oxygenases.
Ernst Schering Research Foundation workshop 2000;(31):65-83.
1999: K M Richards; John S Moody; Lawrence J Marnett
Mechanism of inhibition of porcine leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid.
Biochemistry 1999;38(50):16529-38.
1999: Tibor Valyi-Nagy; Kathrin R Sidell; Lawrence J Marnett; L Jackson Roberts; T S Dermody; Jason D Morrow; Thomas J Montine
Divergence of brain prostaglandin H synthase activity and oxidative damage in mice with encephalitis.
Journal of neuropathology and experimental neurology 1999;58(12):1269-75.
1999: Lawrence J Marnett; Amit S Kalgutkar
Cyclooxygenase 2 inhibitors: discovery, selectivity and the future.
Trends in pharmacological sciences 1999;20(11):465-9.
1999: Thomas J Montine; Kathrin R Sidell; Brenda C Crews; William R Markesbery; Lawrence J Marnett; L Jackson Roberts; Jason D Morrow
Elevated CSF prostaglandin E2 levels in patients with probable AD.
Neurology 1999;53(7):1495-8.
1999: H Mao; G Ramachandra Reddy; Lawrence J Marnett; Michael P Stone
Solution structure of an oligodeoxynucleotide containing the malondialdehyde deoxyguanosine adduct N2-(3-oxo-1-propenyl)-dG (ring-opened M1G) positioned in a (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Biochemistry 1999;38(41):13491-501.
1999: K A Johnson; M L Mierzwa; SP Fink; Lawrence J Marnett
MutS recognition of exocyclic DNA adducts that are endogenous products of lipid oxidation.
The Journal of biological chemistry 1999;274(38):27112-8.
1999: Thomas O Daniel; H Liu; Jason D Morrow; Brenda C Crews; Lawrence J Marnett
Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis.
Cancer research 1999;59(18):4574-7.
1999: J L Stevens; Lawrence J Marnett
Defining molecular toxicology: a perspective.
Chemical research in toxicology 1999;12(9):747-8.
1999: Scott W Rowlinson; Brenda C Crews; CA Lanzo; Lawrence J Marnett
The binding of arachidonic acid in the cyclooxygenase active site of mouse prostaglandin endoperoxide synthase-2 (COX-2). A putative L-shaped binding conformation utilizing the top channel region.
The Journal of biological chemistry 1999;274(33):23305-10.
1999: Lawrence J Marnett; Scott W Rowlinson; Douglas C Goodwin; Amit S Kalgutkar; CA Lanzo
Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition.
The Journal of biological chemistry 1999;274(33):22903-6.
1999: Douglas C Goodwin; Lisa M Landino; Lawrence J Marnett
Effects of nitric oxide and nitric oxide-derived species on prostaglandin endoperoxide synthase and prostaglandin biosynthesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(10):1121-36.
1999: H Mao; Nathalie Schnetz-Boutaud; Jason P Weisenseel; Lawrence J Marnett; Michael P Stone
Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6615-20.
1999: Lawrence J Marnett
Lipid peroxidation-DNA damage by malondialdehyde.
Mutation research 1999;424(1-2):83-95.
1999: Douglas C Goodwin; Lisa M Landino; Lawrence J Marnett
Reactions of prostaglandin endoperoxide synthase with nitric oxide and peroxynitrite.
Drug metabolism reviews 1999;31(1):273-94.
1999: Amit S Kalgutkar; Brenda C Crews; Scott W Rowlinson; C Garner; Lawrence J Marnett
Discovery of a new class of selective cyclooxygenase-2 (COX-2) inhibitor that covalently modifies the isozyme.
Advances in experimental medicine and biology 1999;469():139-43.
1999: Chiara Leuratti; Rajinder Singh; E J Deag; E Griech; R Hughes; Sheila A Bingham; JP Plastaras; Lawrence J Marnett; David E G Shuker
A sensitive immunoslot-blot assay for detection of malondialdehyde-deoxyguanosine in human DNA.
IARC scientific publications 1999;(150):197-203.
1999: Lawrence J Marnett
Chemistry and biology of DNA damage by malondialdehyde.
IARC scientific publications 1999;(150):17-27.
1999: Li Li; Z Zhu; B Joshi; C Zhang; C R Johnson; Lawrence J Marnett; Kenneth V Honn; JD Crissman; AT Porter; Ding "Dean" G. Tang
A novel hydroxamic acid compound, BMD188, demonstrates anti-prostate cancer effects by inducing apoptosis. II: In vivo efficacy and pharmacokinetic studies.
Anticancer research 1999;19(1A):61-9.
1998: Amit S Kalgutkar; Kevin R Kozak; Brenda C Crews; G P Hochgesang; Lawrence J Marnett
Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.
Journal of medicinal chemistry 1998;41(24):4800-18.
1998: Chiara Leuratti; Rajinder Singh; C Lagneau; Peter B Farmer; JP Plastaras; Lawrence J Marnett; David E G Shuker
Determination of malondialdehyde-induced DNA damage in human tissues using an immunoslot blot assay.
Carcinogenesis 1998;19(11):1919-24.
1998: F F Kadlubar; K E Anderson; S Häussermann; N P Lang; G W Barone; P A Thompson; S L MacLeod; Ming W Chou; MV Mikhailova; J Plastaras; Lawrence J Marnett; Urmila Nair; I Velic; Helmut Bartsch
Comparison of DNA adduct levels associated with oxidative stress in human pancreas.
Mutation research 1998;405(2):125-33.
1998: Peter C Dedon; John P Plastaras; C A Rouzer; Lawrence J Marnett
Indirect mutagenesis by oxidative DNA damage: formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11113-6.
1998: Lawrence J Marnett; Amit S Kalgutkar
Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents.
Current opinion in chemical biology 1998;2(4):482-90.
1998: C Ji; Carol A Rouzer; Lawrence J Marnett; Jennifer A Pietenpol
Induction of cell cycle arrest by the endogenous product of lipid peroxidation, malondialdehyde.
Carcinogenesis 1998;19(7):1275-83.
1998: Lawrence J Marnett
Forum: reactive species of peroxynitrite.
Chemical research in toxicology 1998;11(7):709.
1998: Amit S Kalgutkar; Brenda C Crews; Scott W Rowlinson; C Garner; K Seibert; Lawrence J Marnett
Aspirin-like molecules that covalently inactivate cyclooxygenase-2.
Science (New York, N.Y.) 1998;280(5367):1268-70.
1998: S Langouët; A N Mican; M Müller; SP Fink; Lawrence J Marnett; S A Muhle; F Peter Guengerich
Misincorporation of nucleotides opposite five-membered exocyclic ring guanine derivatives by escherichia coli polymerases in vitro and in vivo: 1,N2-ethenoguanine, 5,6,7,9-tetrahydro-9-oxoimidazo[1, 2-a]purine, and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1, 2-a]purine.
Biochemistry 1998;37(15):5184-93.
1998: Douglas C Goodwin; Michael R Gunther; Linda C Hsi; Brenda C Crews; Thomas E Eling; Ronald P Mason; Lawrence J Marnett
Nitric oxide trapping of tyrosyl radicals generated during prostaglandin endoperoxide synthase turnover. Detection of the radical derivative of tyrosine 385.
The Journal of biological chemistry 1998;273(15):8903-9.
1998: CA Lanzo; Joseph M Beechem; John J Talley; Lawrence J Marnett
Investigation of the binding of isoform-selective inhibitors to prostaglandin endoperoxide synthases using fluorescence spectroscopy.
Biochemistry 1998;37(1):217-26.
1998: Ding "Dean" G. Tang; Li Li; Z Zhu; B Joshi; C R Johnson; Lawrence J Marnett; Kenneth V Honn; JD Crissman; S Krajewski; J C Reed; Jozsef Timar; AT Porter
BMD188, A novel hydroxamic acid compound, demonstrates potent anti-prostate cancer effects in vitro and in vivo by inducing apoptosis: requirements for mitochondria, reactive oxygen species, and proteases.
Pathology oncology research : POR 1998;4(3):179-90.
1997: C Ji; Lawrence J Marnett; Jennifer A Pietenpol
Cell cycle re-entry following chemically-induced cell cycle synchronization leads to elevated p53 and p21 protein levels.
Oncogene 1997;15(22):2749-53.
1997: Lisa M Landino; Brenda C Crews; James K Gierse; S D Hauser; Lawrence J Marnett
Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation.
The Journal of biological chemistry 1997;272(34):21565-74.
1997: Muhammed F Hashim; Nathalie Schnetz-Boutaud; Lawrence J Marnett
Replication of template-primers containing propanodeoxyguanosine by DNA polymerase beta. Induction of base pair substitution and frameshift mutations by template slippage and deoxynucleoside triphosphate stabilization.
The Journal of biological chemistry 1997;272(32):20205-12.
1997: SP Fink; G Ramachandra Reddy; Lawrence J Marnett
Mutagenicity in Escherichia coli of the major DNA adduct derived from the endogenous mutagen malondialdehyde.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8652-7.
1997: Michael R Gunther; Linda C Hsi; J F Curtis; J K Gierse; Lawrence J Marnett; Thomas E Eling; Ronald P Mason
Nitric oxide trapping of the tyrosyl radical of prostaglandin H synthase-2 leads to tyrosine iminoxyl radical and nitrotyrosine formation.
The Journal of biological chemistry 1997;272(27):17086-90.
1997: K M Richards; Lawrence J Marnett
Leukocyte 12-lipoxygenase: expression, purification, and investigation of the role of methionine residues in turnover-dependent inactivation and 5,8,11,14-eicosatetraynoic acid inhibition.
Biochemistry 1997;36(22):6692-9.
1997: Laura J Niedernhofer; M Riley; Nathalie Schnetz-Boutaud; G Sanduwaran; AK Chaudhary; G Ramachandra Reddy; Lawrence J Marnett
Temperature-dependent formation of a conjugate between tris(hydroxymethyl)aminomethane buffer and the malondialdehyde-DNA adduct pyrimidopurinone.
Chemical research in toxicology 1997;10(5):556-61.
1997: Lawrence J Marnett
Free radical mechanisms of neurotoxicity.
Chemical research in toxicology 1997;10(5):483-4.
1997: K A Johnson; SP Fink; Lawrence J Marnett
Repair of propanodeoxyguanosine by nucleotide excision repair in vivo and in vitro.
The Journal of biological chemistry 1997;272(17):11434-8.
1997: Carol A Rouzer; AK Chaudhary; M Nokubo; D M Ferguson; G Ramachandra Reddy; Ian A Blair; Lawrence J Marnett
Analysis of the malondialdehyde-2'-deoxyguanosine adduct pyrimidopurinone in human leukocyte DNA by gas chromatography/electron capture/negative chemical ionization/mass spectrometry.
Chemical research in toxicology 1997;10(2):181-8.
1997: C L Sevilla; N H Mahle; N Eliezer; A Uzieblo; S M O'Hara; M Nokubo; R Miller; Carol A Rouzer; Lawrence J Marnett
Development of monoclonal antibodies to the malondialdehyde-deoxyguanosine adduct, pyrimidopurinone.
Chemical research in toxicology 1997;10(2):172-80.
1997: C J Smith; Jason D Morrow; L Jackson Roberts; Lawrence J Marnett
Induction of prostaglandin endoperoxide synthase-1 (COX-1) in a human promonocytic cell line by treatment with the differentiating agent TPA.
Advances in experimental medicine and biology 1997;400A():99-106.
1997: Amit S Kalgutkar; Brenda C Crews; Lawrence J Marnett
Inactivation of prostaglandin endoperoxide synthase (PGHS) by N-(substituted)maleimides.
Advances in experimental medicine and biology 1997;407():79-85.
1996: Lisa M Landino; Brenda C Crews; M D Timmons; Jason D Morrow; Lawrence J Marnett
Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15069-74.
1996: G Gorins; L Kuhnert; C R Johnson; Lawrence J Marnett
(Carboxyalkyl)benzyl propargyl ethers as selective inhibitors of leukocyte-type 12-lipoxygenases.
Journal of medicinal chemistry 1996;39(25):4871-8.
1996: C J Smith; Lawrence J Marnett
Effects of cysteine-to-serine mutations on structural and functional properties of prostaglandin endoperoxide synthase.
Archives of biochemistry and biophysics 1996;335(2):342-50.
1996: Amit S Kalgutkar; Brenda C Crews; Lawrence J Marnett
Kinetics of the interaction of nonsteroidal antiinflammatory drugs with prostaglandin endoperoxide synthase-1 studied by limited proteolysis.
Biochemistry 1996;35(28):9076-82.
1996: Lawrence J Marnett
Nitric oxide: chemical events in toxicity.
Chemical research in toxicology 1996;9(5):807-8.
1996: AK Chaudhary; G Ramachandra Reddy; Ian A Blair; Lawrence J Marnett
Characterization of an N6-oxopropenyl-2'-deoxyadenosine adduct in malondialdehyde-modified DNA using liquid chromatography/electrospray ionization tandem mass spectrometry.
Carcinogenesis 1996;17(5):1167-70.
1996: Amit S Kalgutkar; Brenda C Crews; Lawrence J Marnett
Design, synthesis, and biochemical evaluation of N-substituted maleimides as inhibitors of prostaglandin endoperoxide synthases.
Journal of medicinal chemistry 1996;39(8):1692-703.
1996: M F Hashim; Lawrence J Marnett
Sequence-dependent induction of base pair substitutions and frameshifts by propanodeoxyguanosine during in vitro DNA replication.
The Journal of biological chemistry 1996;271(15):9160-5.
1996: Lisa M Landino; Lawrence J Marnett
Mechanism of hydroperoxide reduction by mangano-prostaglandin endoperoxide synthase.
Biochemistry 1996;35(8):2637-43.
1996: SP Fink; G Ramachandra Reddy; Lawrence J Marnett
Relative contribution of cytosine deamination and error-prone replication to the induction of propanodeoxyguanosine-->deoxyadenosine mutations in Escherichia coli.
Chemical research in toxicology 1996;9(1):277-83.
1996: G Ramachandra Reddy; Lawrence J Marnett
Mechanism of reaction of beta-(aryloxy)acroleins with nucleosides.
Chemical research in toxicology 1996;9(1):12-5.
1996: Lawrence J Marnett
Creation of the probationary division of chemical toxicology.
Chemical research in toxicology 1996;9(1):1-2.
1995: PS Kingma; Anita H Corbett; P C Burcham; Lawrence J Marnett; Neil Osheroff
Abasic sites stimulate double-stranded DNA cleavage mediated by topoisomerase II. DNA lesions as endogenous topoisomerase II poisons.
The Journal of biological chemistry 1995;270(37):21441-4.
1995: Lawrence J Marnett
Report on the monitoring study of Chemical Research in Toxicology.
Chemical research in toxicology 1995;8(4):479-80.
1995: Lawrence J Marnett
Aspirin and related nonsteroidal anti-inflammatory drugs as chemopreventive agents against colon cancer.
Preventive medicine 1995;24(2):103-6.
1995: J P Weisenseel; J G Moe; G Ramachandra Reddy; Lawrence J Marnett; Michael P Stone
Structure of a duplex oligodeoxynucleotide containing propanodeoxyguanosine opposite a two-base deletion in the (CpG)3 frame shift hotspot of Salmonella typhimurium hisD3052 determined by 1H NMR and restrained molecular dynamics.
Biochemistry 1995;34(1):50-64.
1995: Lawrence J Marnett; A L Wilcox
The chemistry of lipid alkoxyl radicals and their role in metal-amplified lipid peroxidation.
Biochemical Society symposium 1995;61():65-72.
1995: M Benamira; K Johnson; A Chaudhary; K Bruner; C Tibbetts; Lawrence J Marnett
Induction of mutations by replication of malondialdehyde-modified M13 DNA in Escherichia coli: determination of the extent of DNA modification, genetic requirements for mutagenesis, and types of mutations induced.
Carcinogenesis 1995;16(1):93-9.
1994: J K Beckman; F Bagheri; C Ji; Ian A Blair; Lawrence J Marnett
Phospholipid peroxidation in tumor promoter-exposed mouse skin.
Carcinogenesis 1994;15(12):2937-44.
1994: Lawrence J Marnett
Generation of mutagens during arachidonic acid metabolism.
Cancer metastasis reviews 1994;13(3-4):303-8.
1994: Lawrence J Marnett; Kenneth V Honn
Overview of articles on eicosanoids and cancer.
Cancer metastasis reviews 1994;13(3-4):237-9.
1994: R G Reddy; T Yoshimoto; S Yamamoto; Lawrence J Marnett
Expression, purification, and characterization of porcine leukocyte 12-lipoxygenase produced in the methylotrophic yeast, Pichia pastoris.
Biochemical and biophysical research communications 1994;205(1):381-8.
1994: P C Burcham; Lawrence J Marnett
Site-specific mutagenesis by a propanodeoxyguanosine adduct carried on an M13 genome.
The Journal of biological chemistry 1994;269(46):28844-50.
1994: C W Heath; Michael J Thun; E R Greenberg; B Levin; Lawrence J Marnett
Nonsteroidal antiinflammatory drugs and human cancer. Report of an interdisciplinary research workshop.
Cancer 1994;74(10):2885-8.
1994: T A Kennedy; C J Smith; Lawrence J Marnett
Investigation of the role of cysteines in catalysis by prostaglandin endoperoxide synthase.
The Journal of biological chemistry 1994;269(44):27357-64.
1994: AK Chaudhary; M Nokubo; G Ramachandra Reddy; S N Yeola; Jason D Morrow; Ian A Blair; Lawrence J Marnett
Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver.
Science (New York, N.Y.) 1994;265(5178):1580-2.
1994: AK Chaudhary; M Nokubo; Lawrence J Marnett; Ian A Blair
Analysis of the malondialdehyde-2'-deoxyguanosine adduct in rat liver DNA by gas chromatography/electron capture negative chemical ionization mass spectrometry.
Biological mass spectrometry 1994;23(8):457-64.
1994: Amit S Kalgutkar; Lawrence J Marnett
Rapid inactivation of prostaglandin endoperoxide synthases by N-(carboxyalkyl)maleimides.
Biochemistry 1994;33(29):8625-8.
1994: R G Reddy; T Yoshimoto; S Yamamoto; Colin D Funk; Lawrence J Marnett
Expression of porcine leukocyte 12-lipoxygenase in a baculovirus/insect cell system and its characterization.
Archives of biochemistry and biophysics 1994;312(1):219-26.
1994: J G Moe; G Ramachandra Reddy; Lawrence J Marnett; Michael P Stone
1H NMR characterization of a duplex oligodeoxynucleotide containing propanodeoxyguanosine opposite a two-base deletion in the (CpG)3 frameshift hotspot of Salmonella typhimurium hisD3052.
Chemical research in toxicology 1994;7(3):319-28.
1994: Kathy J Helzlsouer; G Block; J Blumberg; A T Diplock; M Levine; Lawrence J Marnett; R J Schulplein; J T Spence; M G Simic
Summary of the round table discussion on strategies for cancer prevention: diet, food, additives, supplements, and drugs.
Cancer research 1994;54(7 Suppl):2044s-2051s.
1994: Lawrence J Marnett; C Ji
Modulation of oxidant formation in mouse skin in vivo by tumor-promoting phorbol esters.
Cancer research 1994;54(7 Suppl):1886s-1889s.
1994: Yong Q Chen; Z M Duniec; B Liu; Wolfgang Hagmann; X Gao; K Shimoji; Lawrence J Marnett; C R Johnson; Kenneth V Honn
Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.
Cancer research 1994;54(6):1574-9.
1994: B Liu; Lawrence J Marnett; A Chaudhary; C Ji; Ian Blair; C R Johnson; Clement A Diglio; Kenneth V Honn
Biosynthesis of 12(S)-hydroxyeicosatetraenoic acid by B16 amelanotic melanoma cells is a determinant of their metastatic potential.
Laboratory investigation; a journal of technical methods and pathology 1994;70(3):314-23.
1994: Lawrence J Marnett
DNA adducts of alpha,beta-unsaturated aldehydes and dicarbonyl compounds.
IARC scientific publications 1994;(125):151-63.
1993: U S Singh; J G Moe; G Ramachandra Reddy; J P Weisenseel; Lawrence J Marnett; Michael P Stone
1H NMR of an oligodeoxynucleotide containing a propanodeoxyguanosine adduct positioned in a (CG)3 frameshift hotspot of Salmonella typhimurium hisD3052: Hoogsteen base-pairing at pH 5.8.
Chemical research in toxicology 1993;6(6):825-36.
1993: Lawrence J Marnett; P C Burcham
Endogenous DNA adducts: potential and paradox.
Chemical research in toxicology 1993;6(6):771-85.
1993: A L Wilcox; Lawrence J Marnett
Polyunsaturated fatty acid alkoxyl radicals exist as carbon-centered epoxyallylic radicals: a key step in hydroperoxide-amplified lipid peroxidation.
Chemical research in toxicology 1993;6(4):413-6.
1993: M Benamira; Lawrence J Marnett
Construction of a vector for site-specific frameshift mutagenesis containing the mutable hotspot of Salmonella typhimurium TA98 on an M13 bacteriophage.
Chemical research in toxicology 1993;6(3):317-27.
1993: C J Smith; J D Morrow; L J Roberts; Lawrence J Marnett
Differentiation of monocytoid THP-1 cells with phorbol ester induces expression of prostaglandin endoperoxide synthase-1 (COX-1).
Biochemical and biophysical research communications 1993;192(2):787-93.
1993: I Wells; Lawrence J Marnett
Inactivation of prostaglandin endoperoxide synthase by acylating derivatives of indomethacin.
Biochemistry 1993;32(10):2710-6.
1993: E Blée; A L Wilcox; Lawrence J Marnett; Francis Schuber
Mechanism of reaction of fatty acid hydroperoxides with soybean peroxygenase.
The Journal of biological chemistry 1993;268(3):1708-15.
1992: J A DeGray; G Lassmann; J F Curtis; T A Kennedy; Lawrence J Marnett; Thomas E Eling; Ronald P Mason
Spectral analysis of the protein-derived tyrosyl radicals from prostaglandin H synthase.
The Journal of biological chemistry 1992;267(33):23583-8.
1992: M Benamira; U Singh; Lawrence J Marnett
Site-specific frameshift mutagenesis by a propanodeoxyguanosine adduct positioned in the (CpG)4 hot-spot of Salmonella typhimurium hisD3052 carried on an M13 vector.
The Journal of biological chemistry 1992;267(31):22392-400.
1992: H K Jajoo; P C Burcham; Y Goda; Ian A Blair; Lawrence J Marnett
A thermospray liquid chromatography/mass spectrometry method for analysis of human urine for the major malondialdehyde-guanine adduct.
Chemical research in toxicology 1992;5(6):870-5.
1992: Lawrence J Marnett
Of mice and men: human risk assessment based on high-dose rodent exposure.
Chemical research in toxicology 1992;5(6):735-6.
1992: M Benamira; Lawrence J Marnett
The lipid peroxidation product 4-hydroxynonenal is a potent inducer of the SOS response.
Mutation research 1992;293(1):1-10.
1992: Lawrence J Marnett
Aspirin and the potential role of prostaglandins in colon cancer.
Cancer research 1992;52(20):5575-89.
1992: I Wells; Lawrence J Marnett
Acetylation of prostaglandin endoperoxide synthase by N-acetylimidazole: comparison to acetylation by aspirin.
Biochemistry 1992;31(40):9520-5.
1992: C Ji; Lawrence J Marnett
Oxygen radical-dependent epoxidation of (7S,8S)-dihydroxy-7,8-dihydrobenzo[a]pyrene in mouse skin in vivo. Stimulation by phorbol esters and inhibition by antiinflammatory steroids.
The Journal of biological chemistry 1992;267(25):17842-8.
1992: R Odenwaller; Krishna Rao Maddipati; Lawrence J Marnett
Detection of a higher oxidation state of manganese-prostaglandin endoperoxide synthase.
The Journal of biological chemistry 1992;267(20):13863-9.
1992: I Pal; R Odenwaller; Lawrence J Marnett
7-Oxabicycloheptylprostanoic acids: potent, time-dependent cyclooxygenase inhibitors that induce a conformational change in the prostaglandin endoperoxide synthase protein.
Journal of medicinal chemistry 1992;35(12):2340-2.
1992: William L Smith; T E Eling; Richard J Kulmacz; Lawrence J Marnett; A l Tsai
Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase.
Biochemistry 1992;31(1):3-7.
1992: Ashok Reddy; D Pruess-Schwartz; C Ji; P Gorycki; Lawrence J Marnett
32P-postlabeling analysis of DNA adduction in mouse skin following topical administration of (+)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene.
Chemical research in toxicology 1992;5(1):26-33.
1992: Ashok Reddy; D Pruess-Schwartz; Lawrence J Marnett
Separation of (+)-syn- and (-)-anti-benzo[a]pyrene dihydrodiol epoxide-DNA adducts in 32P-postlabeling analysis.
Chemical research in toxicology 1992;5(1):19-25.
1991: M C Chapeau; Lawrence J Marnett
Enzymatic synthesis of purine deoxynucleoside adducts.
Chemical research in toxicology 1991;4(6):636-8.
1991: G Lassmann; R Odenwaller; J F Curtis; J A DeGray; Ronald P Mason; Lawrence J Marnett; Thomas E Eling
Electron spin resonance investigation of tyrosyl radicals of prostaglandin H synthase. Relation to enzyme catalysis.
The Journal of biological chemistry 1991;266(30):20045-55.
1991: Y Goda; Lawrence J Marnett
High-performance liquid chromatography with electrochemical detection for determination of the major malondialdehyde-guanine adduct.
Chemical research in toxicology 1991;4(5):520-4.
1991: William L Smith; Lawrence J Marnett
Prostaglandin endoperoxide synthase: structure and catalysis.
Biochimica et biophysica acta 1991;1083(1):1-17.
1991: S M O'Hara; Lawrence J Marnett
DNA sequence analysis of spontaneous and beta-methoxy-acrolein-induced mutations in Salmonella typhimurium hisD3052.
Mutation research 1991;247(1):45-56.
1991: Lawrence J Marnett
Peroxyl free radicals: biological reactive intermediates produced during lipid oxidation.
Advances in experimental medicine and biology 1991;283():65-70.
1991: William L Smith; Lawrence J Marnett; D L DeWitt
Prostaglandin and thromboxane biosynthesis.
Pharmacology & therapeutics 1991;49(3):153-79.
1991: R Odenwaller; C Y O'Gara; Lawrence J Marnett
Properties of trypsin-cleaved PGH synthase.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():81-4.
1991: Lawrence J Marnett; M T Leithauser; K M Richards; I Blair; Kenneth V Honn; S Yamamoto; T Yoshimoto
Arachidonic acid metabolism of cytosolic fractions of Lewis lung carcinoma cells.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21B():895-900.
1990: Asfar S Azmi; G Radcliff; D M Callewaert; Lawrence J Marnett; T Eling; D S Daston; WJ Caspary
Mutagenic response of mouse lymphoma cells after activation of benzidine and 2-aminofluorene with purified prostaglandin H synthase.
Mutation research 1990;242(4):319-28.
1990: K Stone; A Uzieblo; Lawrence J Marnett
Studies of the reaction of malondialdehyde with cytosine nucleosides.
Chemical research in toxicology 1990;3(5):467-72.
1990: Lawrence J Marnett
Prostaglandin synthase-mediated metabolism of carcinogens and a potential role for peroxyl radicals as reactive intermediates.
Environmental health perspectives 1990;88():5-12.
1990: D C Laudicina; Lawrence J Marnett
Enhancement of hydroperoxide-dependent lipid peroxidation in rat liver microsomes by ascorbic acid.
Archives of biochemistry and biophysics 1990;278(1):73-80.
1990: V M Samokyszyn; Lawrence J Marnett
Inhibition of liver microsomal lipid peroxidation by 13-cis-retinoic acid.
Free radical biology & medicine 1990;8(5):491-6.
1990: Lawrence J Marnett; A Reddy; D Pruess-Schwartz; C Ji
Oxidation of polycyclic hydrocarbons by oxygen radicals.
Princess Takamatsu symposia 1990;21():63-73.
1990: K Stone; Mohamad Ksebati; Lawrence J Marnett
Investigation of the adducts formed by reaction of malondialdehyde with adenosine.
Chemical research in toxicology 1990;3(1):33-8.
1990: R Odenwaller; Y N Chen; Lawrence J Marnett
Preparation and proteolytic cleavage of apoprostaglandin endoperoxide synthase.
Methods in enzymology 1990;187():479-85.
1990: V M Samokyszyn; Lawrence J Marnett
Inhibition of microsomal lipid peroxidation by 13-cis-retinoic acid.
Methods in enzymology 1990;190():281-8.
1989: Tsutomu Shimada; M V Martin; D Pruess-Schwartz; Lawrence J Marnett; F Peter Guengerich
Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.
Cancer research 1989;49(22):6304-12.
1989: C Y O'Gara; Krishna Rao Maddipati; Lawrence J Marnett
A sensitive electrochemical method for quantitative hydroperoxide determination.
Chemical research in toxicology 1989;2(5):295-300.
1989: Y N Chen; Lawrence J Marnett
Heme prosthetic group required for acetylation of prostaglandin H synthase by aspirin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(11):2294-7.
1989: P Plé; Lawrence J Marnett
Alkylaryl sulfides as peroxidase reducing substrates for prostaglandin H synthase. Probes for the reactivity and environment of the ferryl-oxo complex.
The Journal of biological chemistry 1989;264(24):13983-93.
1989: D Pruess-Schwartz; A Nimesheim; Lawrence J Marnett
Peroxyl radical- and cytochrome P-450-dependent metabolic activation of (+)-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in mouse skin in vitro and in vivo.
Cancer research 1989;49(7):1732-7.
1989: Lawrence J Marnett; Y N Chen; Krishna Rao Maddipati; R Labeque; P Ple
Localization of the peroxidase active site of PGH synthase.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():458-61.
1988: Lawrence J Marnett; Y N Chen; Krishna Rao Maddipati; P Plé; R Labèque
Functional differentiation of cyclooxygenase and peroxidase activities of prostaglandin synthase by trypsin treatment. Possible location of a prosthetic heme binding site.
The Journal of biological chemistry 1988;263(32):16532-5.
1988: G Padbury; Stephen G Sligar; R Labeque; Lawrence J Marnett
Ferric bleomycin catalyzed reduction of 10-hydroperoxy-8,12-octadecadienoic acid: evidence for homolytic O-O bond scission.
Biochemistry 1988;27(20):7846-52.
1988: C A O'Brian; Nancy E Ward; I B Weinstein; A W Bull; Lawrence J Marnett
Activation of rat brain protein kinase C by lipid oxidation products.
Biochemical and biophysical research communications 1988;155(3):1374-80.
1988: R Labeque; Lawrence J Marnett
Reaction of hematin with allylic fatty acid hydroperoxides: identification of products and implications for pathways of hydroperoxide-dependent epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene.
Biochemistry 1988;27(18):7060-70.
1988: H Chopra; J S Hatfield; Y S Chang; I M Grossi; L A Fitzgerald; C Y O'Gara; Lawrence J Marnett; Clement A Diglio; John D Taylor; Kenneth V Honn
Role of tumor cytoskeleton and membrane glycoprotein IRGpIIb/IIIa in platelet adhesion to tumor cell membrane and tumor cell-induced platelet aggregation.
Cancer research 1988;48(13):3787-800.
1988: Arthur W Bull; N D Nigro; Lawrence J Marnett
Structural requirements for stimulation of colonic cell proliferation by oxidized fatty acids.
Cancer research 1988;48(7):1771-6.
1988: J Capdevila; Lionel Gil; Myriam Orellana; Lawrence J Marnett; J I Mason; P Yadagiri; John R Falck
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.
Archives of biochemistry and biophysics 1988;261(2):257-63.
1988: A K Basu; S M O'Hara; P Valladier; K Stone; O Mols; Lawrence J Marnett
Identification of adducts formed by reaction of guanine nucleosides with malondialdehyde and structurally related aldehydes.
Chemical research in toxicology 1988;1(1):53-9.
1987: Krishna Rao Maddipati; Lawrence J Marnett
Characterization of the major hydroperoxide-reducing activity of human plasma. Purification and properties of a selenium-dependent glutathione peroxidase.
The Journal of biological chemistry 1987;262(36):17398-403.
1987: Y N Chen; M J Bienkowski; Lawrence J Marnett
Controlled tryptic digestion of prostaglandin H synthase. Characterization of protein fragments and enhanced rate of proteolysis of oxidatively inactivated enzyme.
The Journal of biological chemistry 1987;262(35):16892-9.
1987: David G Menter; B W Steinert; Bonnie F Sloane; N Gundlach; C Y O'Gara; Lawrence J Marnett; Clement A Diglio; D Walz; John D Taylor; Kenneth V Honn
Role of platelet membrane in enhancement of tumor cell adhesion to endothelial cell extracellular matrix.
Cancer research 1987;47(24 Pt 1):6751-62.
1987: V M Samokyszyn; Lawrence J Marnett
Hydroperoxide-dependent cooxidation of 13-cis-retinoic acid by prostaglandin H synthase.
The Journal of biological chemistry 1987;262(29):14119-33.
1987: Lawrence J Marnett
Peroxyl free radicals: potential mediators of tumor initiation and promotion.
Carcinogenesis 1987;8(10):1365-73.
1987: C M Markey; A Alward; P E Weller; Lawrence J Marnett
Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities.
The Journal of biological chemistry 1987;262(13):6266-79.
1987: Krishna Rao Maddipati; C Gasparski; Lawrence J Marnett
Characterization of the hydroperoxide-reducing activity of human plasma.
Archives of biochemistry and biophysics 1987;254(1):9-17.
1987: A W Bull; Kamran S Moghissi; K Wachsman; Lawrence J Marnett
Copper-containing IUDs are not associated with an increase of malondialdehyde levels in cervical mucus.
Contraception 1987;35(1):49-55.
1987: A M Lambeir; C M Markey; H Brian Dunford; Lawrence J Marnett
Spectral properties of the higher oxidation states of prostaglandin H synthase.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17A():25-8.
1986: T Eling; J Curtis; J Battista; Lawrence J Marnett
Oxidation of (+)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by mouse keratinocytes: evidence for peroxyl radical- and monoxygenase-dependent metabolism.
Carcinogenesis 1986;7(12):1957-63.
1986: Thomas A Dix; J R Buck; Lawrence J Marnett
Hydroperoxide-dependent epoxidation of 3,4-dihydroxy-3,4-dihydrobenzo[a]anthracene by ram seminal vesicle microsomes and by hematin.
Biochemical and biophysical research communications 1986;140(1):181-7.
1986: Lawrence J Marnett; A K Basu; S M O'Hara
The role of cyclic nucleic acid adducts in the mutational specificity of malondialdehyde and beta-substituted acroleins in Salmonella.
IARC scientific publications 1986;(70):175-83.
1985: A M Lambeir; C M Markey; H B Dunford; Lawrence J Marnett
Spectral properties of the higher oxidation states of prostaglandin H synthase.
The Journal of biological chemistry 1985;260(28):14894-6.
1985: P E Weller; C M Markey; Lawrence J Marnett
Enzymatic reduction of 5-phenyl-4-pentenyl-hydroperoxide: detection of peroxidases and identification of peroxidase reducing substrates.
Archives of biochemistry and biophysics 1985;243(2):633-43.
1985: A W Bull; Lawrence J Marnett
Determination of malondialdehyde by ion-pairing high-performance liquid chromatography.
Analytical biochemistry 1985;149(1):284-90.
1985: Lawrence J Marnett; J Buck; M A Tuttle; A K Basu; A W Bull
Distribution and oxidation of malondialdehyde in mice.
Prostaglandins 1985;30(2):241-54.
1985: J R Battista; Lawrence J Marnett
Prostaglandin H synthase-dependent epoxidation of aflatoxin B1.
Carcinogenesis 1985;6(8):1227-9.
1985: Kenneth V Honn; Lawrence J Marnett
Requirement of a reactive alpha, beta-unsaturated carbonyl for inhibition of tumor growth and induction of differentiation by "A" series prostaglandins.
Biochemical and biophysical research communications 1985;129(1):34-40.
1985: Thomas A Dix; R Fontana; A Panthani; Lawrence J Marnett
Hematin-catalyzed epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by polyunsaturated fatty acid hydroperoxides.
The Journal of biological chemistry 1985;260(9):5358-65.
1985: Thomas A Dix; Lawrence J Marnett
Conversion of linoleic acid hydroperoxide to hydroxy, keto, epoxyhydroxy, and trihydroxy fatty acids by hematin.
The Journal of biological chemistry 1985;260(9):5351-7.
1985: Lawrence J Marnett; H K Hurd; M C Hollstein; David E Levin; H Esterbauer; B N Ames
Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104.
Mutation research 1985;148(1-2):25-34.
1985: Kenneth V Honn; P Weller; Lawrence J Marnett
Effects of prostaglandins possessing an alpha,beta-unsaturated carbonyl on tumor growth and differentiation.
Advances in prostaglandin, thromboxane, and leukotriene research 1985;15():411-3.
1985: Lawrence J Marnett; P E Weller; C M Markey; A Alward; Thomas A Dix
Transformations of unsaturated fatty acid hydroperoxides.
Advances in prostaglandin, thromboxane, and leukotriene research 1985;15():143-6.
1984: Arthur W Bull; N D Nigro; W A Golembieski; JD Crissman; Lawrence J Marnett
In vivo stimulation of DNA synthesis and induction of ornithine decarboxylase in rat colon by fatty acid hydroperoxides, autoxidation products of unsaturated fatty acids.
Cancer research 1984;44(11):4924-8.
1984: V M Samokyszyn; Bonnie F Sloane; Kenneth V Honn; Lawrence J Marnett
Cooxidation of 13-cis-retinoic acid by prostaglandin H synthase.
Biochemical and biophysical research communications 1984;124(2):430-6.
1984: A K Basu; Lawrence J Marnett; Louis J Romano
Dissociation of malondialdehyde mutagenicity in Salmonella typhimurium from its ability to induce interstrand DNA cross-links.
Mutation research 1984;129(1):39-46.
1984: Lawrence J Marnett; P H Siedlik; R C Ochs; W R Pagels; M Das; Kenneth V Honn; R H Warnock; B E Tainer; T E Eling
Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom.
Molecular pharmacology 1984;26(2):328-35.
1984: David E Levin; Lawrence J Marnett; B N Ames
Spontaneous and mutagen-induced deletions: mechanistic studies in Salmonella tester strain TA102.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(14):4457-61.
1984: A K Basu; Lawrence J Marnett
Molecular requirements for the mutagenicity of malondialdehyde and related acroleins.
Cancer research 1984;44(7):2848-54.
1984: Thomas A Dix; Lawrence J Marnett
Detection of the metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation.
Methods in enzymology 1984;105():347-52.
1984: P H Siedlik; Lawrence J Marnett
Oxidizing radical generation by prostaglandin H synthase.
Methods in enzymology 1984;105():412-6.
1983: M D Sevilla; P Neta; Lawrence J Marnett
Reaction of the antithrombotic and antimetastatic agent, nafazatrom, with oxidizing radicals.
Biochemical and biophysical research communications 1983;115(3):800-6.
1983: Thomas A Dix; Lawrence J Marnett
Metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation.
Science (New York, N.Y.) 1983;221(4605):77-9.
1983: W R Pagels; R J Sachs; Lawrence J Marnett; D L Dewitt; J S Day; William L Smith
Immunochemical evidence for the involvement of prostaglandin H synthase in hydroperoxide-dependent oxidations by ram seminal vesicle microsomes.
The Journal of biological chemistry 1983;258(10):6517-23.
1983: S M Fischer; S Ogle; Lawrence J Marnett; S Nesnow; Thomas Slaga
The lack of initiating and/or promoting activity of sodium malondialdehyde on SENCAR mouse skin.
Cancer letters 1983;19(1):61-6.
1983: A Panthananickal; P Weller; Lawrence J Marnett
Stereoselectivity of the epoxidation of 7,8-dihydrobenzo[a]pyrene by prostaglandin H synthase and cytochrome P-450 determined by the identification of polyguanylic acid adducts.
The Journal of biological chemistry 1983;258(7):4411-8.
1983: K C Morton; C M King; J B Vaught; C Y Wang; M S Lee; Lawrence J Marnett
Prostaglandin H synthase-mediated reaction of carcinogenic arylamines with tRNA and homopolyribonucleotides.
Biochemical and biophysical research communications 1983;111(1):96-103.
1983: Arthur W Bull; Lawrence J Marnett; Elizabeth Jean Dawe; N D Nigro
Stimulation of deoxythymidine incorporation in the colon of rats treated intrarectally with bile acids and fats.
Carcinogenesis 1983;4(2):207-10.
1983: A K Basu; Lawrence J Marnett
Unequivocal demonstration that malondialdehyde is a mutagen.
Carcinogenesis 1983;4(3):331-3.
1983: Lawrence J Marnett; Thomas A Dix; R J Sachs; P H Siedlik
Oxidations by fatty acid hydroperoxides and prostaglandin synthase.
Advances in prostaglandin, thromboxane, and leukotriene research 1983;11():79-86.
1982: G A Reed; Lawrence J Marnett
Metabolism and activation of 7,8-dihydrobenzo[a]pyrene during prostaglandin biosynthesis. Intermediacy of a bay-region epoxide.
The Journal of biological chemistry 1982;257(19):11368-76.
1982: Lawrence J Marnett; P H Siedlik; Leslie W-M Fung
Oxidation of phenidone and BW755C by prostaglandin endoperoxide synthetase.
The Journal of biological chemistry 1982;257(12):6957-64.
1982: J Capdevila; Lawrence J Marnett; N Chacos; R A Prough; Ronald W Estabrook
Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(3):767-70.
1982: Lawrence J Marnett; A Panthananickal; G A Reed
Metabolic activation of 7,8-dihydroxy-7,8-dihydrobenzo[a]-pyrene during prostaglandin biosynthesis.
Drug metabolism reviews 1982;13(2):235-47.
1981: Lawrence J Marnett
Polycyclic aromatic hydrocarbon oxidation during prostaglandin biosynthesis.
Life sciences 1981;29(6):531-46.
1981: Kenneth V Honn; R S Bockman; Lawrence J Marnett
Prostaglandins and cancer: a review of tumor initiation through tumor metastasis.
Prostaglandins 1981;21(5):833-64.
1981: A Panthananickal; Lawrence J Marnett
Arachidonic acid-dependent metabolism of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to polyguanylic acid-binding derivatives.
Chemico-biological interactions 1981;33(2-3):239-52.
1980: Lawrence J Marnett; M J Bienkowski
Hydroperoxide-dependent oxygenation of trans-7,8-dihydroxy-7,8-dihydro benzo[a]pyrene by ram seminal vesicle microsomes. Source of the oxygen.
Biochemical and biophysical research communications 1980;96(2):639-47.
1980: Lawrence J Marnett; M A Tuttle
Comparison of the mutagenicities of malondialdehyde and the side products formed during its chemical synthesis.
Cancer research 1980;40(2):276-82.
1980: N A Porter; R A Wolf; W R Pagels; Lawrence J Marnett
A test for the intermediacy of 11-hydroperoxyeicosa-5,8,12,14-tetraenoic acid [11-HPETE] in prostaglandin biosynthesis.
Biochemical and biophysical research communications 1980;92(2):349-55.
1980: R W Egan; P H Gale; G C Beveridge; Lawrence J Marnett; F A Kuehl
Direct and indirect involvement of radical scavengers during prostaglandin biosynthesis.
Advances in prostaglandin and thromboxane research 1980;6():153-5.
1980: Lawrence J Marnett; M J Bienkowski; W R Pagels; G A Reed
Mechanism of xenobiotic cooxygenation coupled to prostaglandin H2 biosynthesis.
Advances in prostaglandin and thromboxane research 1980;6():149-51.
1979: Lawrence J Marnett; M J Bienkowski; M Raban; M A Tuttle
Studies of the hydrolysis of 14C-labeled tetraethoxypropane to malondialdehyde.
Analytical biochemistry 1979;99(2):458-63.
1979: Lawrence J Marnett; J T Johnson; M J Bienkowski
Arachidonic acid-dependent metabolism of 7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene by ram seminal vesicles.
FEBS letters 1979;106(1):13-6.
1979: Lawrence J Marnett; G A Reed
Peroxidatic oxidation of benzo[a]pyrene and prostaglandin biosynthesis.
Biochemistry 1979;18(14):2923-9.
1979: Lawrence J Marnett; M J Bienkowski; W R Pagels
Oxygen 18 investigation of the prostaglandin synthetase-dependent co-oxidation of diphenylisobenzofuran.
The Journal of biological chemistry 1979;254(12):5077-82.
1979: Kenneth V Honn; J R Dunn; L R Morgan; M Bienkowski; Lawrence J Marnett
Inhibition of DNA synthesis in Harding-Passey melanoma cells by prostaglandins A1 and A2: comparison with chemotherapeutic agents.
Biochemical and biophysical research communications 1979;87(3):795-801.
1979: H Iida; J Kimura; J J Johnson; Lawrence J Marnett
Microsomal drug hydroxylase activity of Tetrahymena pyriformis.
Comparative biochemistry and physiology. C: Comparative pharmacology 1979;63C(2):381-7.
1978: R W Egan; P H Gale; G C Beveridge; G B Phillips; Lawrence J Marnett
Radical scavenging as the mechanism for stimulation of prostaglandin cyclooxygenase and depression of inflammation by lipoic acid and sodium iodide.
Prostaglandins 1978;16(6):861-9.
1978: Lawrence J Marnett; G A Reed; D J Dennison
Prostaglandin synthetase dependent activation of 7,8-dihydro-7,8-dihydroxy-geno (a) pyrene to mutagenic derivativies.
Biochemical and biophysical research communications 1978;82(1):210-6.
1977: Lawrence J Marnett; G A Reed; J T Johnson
Prostaglandin synthetase dependent benzo(a)pyrene oxidation: products of the oxication and inhibition of their formation by antioxidants.
Biochemical and biophysical research communications 1977;79(2):569-76.
1977: Lawrence J Marnett; M J Bienkowski
Nonenzymatic reduction of prostaglandin H by lipoic acid.
Biochemistry 1977;16(19):4303-7.
1977: Lawrence J Marnett; C L Wilcox
Stimulation of prostaglandin biosynthesis by lipoic acid.
Biochimica et biophysica acta 1977;487(1):222-30.
1975: Lawrence J Marnett; P Wlodawer; Bengt Samuelsson
Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland.
The Journal of biological chemistry 1975;250(21):8510-7.
1974: Lawrence J Marnett; P Wlodawer; Bengt Samuelsson
Light emission during the action of prostaglandin synthetase.
Biochemical and biophysical research communications 1974;60(4):1286-94.