Lawrence Marnett

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Chemicals & Drugs

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Patel Sachin; Kingsley Philip J; Mackie Ken; Marnett Lawrence J; Winder Danny G
Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala.
Daniels R Nathan; Melancon Bruce J; Wang Emily A; Crews Brenda C; Marnett Lawrence J; Sulikowski Gary A; Lindsley Craig W
Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A.
Kingsley Philip J; Marnett Lawrence J
Analysis of endocannabinoids, their congeners and COX-2 metabolites.

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All Publications

2009: Patel Sachin; Kingsley Philip J; Mackie Ken; Marnett Lawrence J; Winder Danny G
Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(13):2699-709.
2009: Daniels R Nathan; Melancon Bruce J; Wang Emily A; Crews Brenda C; Marnett Lawrence J; Sulikowski Gary A; Lindsley Craig W
Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A.
The Journal of organic chemistry 2009;74(22):8852-5.
2009: Kingsley Philip J; Marnett Lawrence J
Analysis of endocannabinoids, their congeners and COX-2 metabolites.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(26):2746-54.
2009: Prusakiewicz Jeffery J; Duggan Kelsey C; Rouzer Carol A; Marnett Lawrence J
Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid.
Biochemistry 2009;48(31):7353-5.
2009: Eoff Robert L; Stafford Jennifer B; Szekely Jozsef; Rizzo Carmelo J; Egli Martin; Guengerich F Peter; Marnett Lawrence J
Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct.
Biochemistry 2009;48(30):7079-88.
2009: Ghidu Victor P; Ntai Ioanna; Wang Jingqi; Jacobs Aaron T; Marnett Lawrence J; Bachmann Brian O; Sulikowski Gary A
Combined chemical and biosynthetic route to access a new apoptolidin congener.
Organic letters 2009;11(14):3032-4.
2009: Walters Matthew J; Blobaum Anna L; Kingsley Philip J; Felts Andrew S; Sulikowski Gary A; Marnett Lawrence J
The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives.
Bioorganic & medicinal chemistry letters 2009;19(12):3271-4.
2009: Konkle Mary E; Hargrove Tatiana Y; Kleshchenko Yuliya Y; von Kries Jens P; Ridenour Whitney; Uddin Md Jashim; Caprioli Richard M; Marnett Lawrence J; Nes W David; Villalta Fernando; Waterman Michael R; Lepesheva Galina I
Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.
Journal of medicinal chemistry 2009;52(9):2846-53.
2009: Marnett Lawrence J
Mechanisms of cyclooxygenase-2 inhibition and cardiovascular side effects: the plot thickens.
Cancer prevention research (Philadelphia, Pa.) 2009;2(4):288-90.
2009: Jacobs Aaron T; Marnett Lawrence J
HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins.
The Journal of biological chemistry 2009;284(14):9176-83.
2009: Rouzer Carol A; Marnett Lawrence J
Cyclooxygenases: structural and functional insights.
Journal of lipid research 2009;50 Suppl():S29-34.
2009: Knutson Charles G; Rubinson Emily H; Akingbade Dapo; Anderson Carolyn S; Stec Donald F; Petrova Katya V; Kozekov Ivan D; Guengerich F Peter; Rizzo Carmelo J; Marnett Lawrence J
Oxidation and glycolytic cleavage of etheno and propano DNA base adducts.
Biochemistry 2009;48(4):800-9.
2009: Sun Xiaofei; Wang Haibin; Okabe Masaru; Mackie Kenneth; Kingsley Philip J; Marnett Lawrence J; Cravatt Benjamin F; Dey Sudhansu K
Genetic loss of Faah compromises male fertility in mice.
Biology of reproduction 2009;80(2):235-42.
2009: Stafford Jennifer B; Eoff Robert L; Kozekova Albena; Rizzo Carmelo J; Guengerich F Peter; Marnett Lawrence J
Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one.
Biochemistry 2009;48(2):471-80.
2009: Marnett Lawrence J
The COXIB experience: a look in the rearview mirror.
Annual review of pharmacology and toxicology 2009;49():265-90.
2008: Uddin Md Jashim; Marnett Lawrence J
Synthesis of 5- and 6-carboxy-X-rhodamines.
Organic letters 2008;10(21):4799-801.
2008: Toscano Christopher D; Kingsley Philip J; Marnett Lawrence J; Bosetti Francesca
NMDA-induced seizure intensity is enhanced in COX-2 deficient mice.
Neurotoxicology 2008;29(6):1114-20.
2008: Marnett Lawrence J
Biochemistry: Divergence from the superfamily.
Nature 2008;455(7211):300-1.
2008: VanderVeen Laurie A; Harris Thomas M; Jen-Jacobson Linda; Marnett Lawrence J
Formation of DNA-protein cross-links between gamma-hydroxypropanodeoxyguanosine and EcoRI.
Chemical research in toxicology 2008;21(9):1733-8.
2008: Adams T B; Gavin C Lucas; Taylor S V; Waddell W J; Cohen S M; Feron V J; Goodman J; Rietjens I M C M; Marnett L J; Portoghese P S; Smith R L
The FEMA GRAS assessment of alpha,beta-unsaturated aldehydes and related substances used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(9):2935-67.
2008: Felts Andrew S; Siegel Brianna S; Young Shiu M; Moth Christopher W; Lybrand Terry P; Dannenberg Andrew J; Marnett Lawrence J; Subbaramaiah Kotha
Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition.
Journal of medicinal chemistry 2008;51(16):4911-9.
2008: Wang Yazhen; Musser Sarah K; Saleh Sam; Marnett Lawrence J; Egli Martin; Stone Michael P
Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IV.
Biochemistry 2008;47(28):7322-34.
2008: Ghidu Victor P; Wang Jingqi; Wu Bin; Liu Qingsong; Jacobs Aaron; Marnett Lawrence J; Sulikowski Gary A
Synthesis and evaluation of the cytotoxicity of apoptolidinones A and D.
The Journal of organic chemistry 2008;73(13):4949-55.
2008: Knutson Charles G; Skipper Paul L; Liberman Rosa G; Tannenbaum Steven R; Marnett Lawrence J
Monitoring in vivo metabolism and elimination of the endogenous DNA adduct, M1dG {3-(2-deoxy-beta-D-erythro-pentofuranosyl)pyrimido[1,2-alpha]purin-10(3H)-one}, by accelerator mass spectrometry.
Chemical research in toxicology 2008;21(6):1290-4.
2008: Bala Manju; Chin Cindy N; Logan Asha T; Amin Taneem; Marnett Lawrence J; Boutaud Olivier; Oates John A
Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase.
Biochemical pharmacology 2008;75(7):1472-81.
2008: Turman Melissa V; Kingsley Philip J; Rouzer Carol A; Cravatt Benjamin F; Marnett Lawrence J
Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.
Biochemistry 2008;47(12):3917-25.
2008: Rouzer Carol A; Marnett Lawrence J
Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoids.
The Journal of biological chemistry 2008;283(13):8065-9.
2008: Vila Andrew; Tallman Keri A; Jacobs Aaron T; Liebler Daniel C; Porter Ned A; Marnett Lawrence J
Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives.
Chemical research in toxicology 2008;21(2):432-44.
2008: Szekely Joseph; Rizzo Carmelo J; Marnett Lawrence J
Chemical properties of oxopropenyl adducts of purine and pyrimidine nucleosides and their reactivity toward amino acid cross-link formation.
Journal of the American Chemical Society 2008;130(7):2195-201.
2008: Szekely Jozsef; Wang Hao; Peplowski Katherine M; Knutson Charles G; Marnett Lawrence J; Rizzo Carmelo J
"One-pot" syntheses of malondialdehyde adducts of nucleosides.
Nucleosides, nucleotides & nucleic acids 2008;27(2):103-9.
2008: Stafford Jennifer B; Marnett Lawrence J
Prostaglandin E2 inhibits tumor necrosis factor-alpha RNA through PKA type I.
Biochemical and biophysical research communications 2008;366(1):104-9.
2007: Knutson Charles G; Wang Hao; Rizzo Carmelo J; Marnett Lawrence J
Metabolism and elimination of the endogenous DNA adduct, 3-(2-deoxy-beta-D-erythropentofuranosyl)-pyrimido[1,2-alpha]purine-10(3H)-one, in the rat.
The Journal of biological chemistry 2007;282(50):36257-64.
2007: Jacobs Aaron T; Marnett Lawrence J
Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL.
The Journal of biological chemistry 2007;282(46):33412-20.
2007: Druckova Alexandra; Mernaugh Raymond L; Ham Amy-Joan L; Marnett Lawrence J
Identification of the protein targets of the reactive metabolite of teucrin A in vivo in the rat.
Chemical research in toxicology 2007;20(10):1393-408.
2007: Marnett Lawrence J
AuthorChoice: a great way to get your papers read.
Chemical research in toxicology 2007;20(9):1235-6.
2007: Harman Christine A; Turman Melissa V; Kozak Kevin R; Marnett Lawrence J; Smith William L; Garavito R Michael
Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides.
The Journal of biological chemistry 2007;282(38):28096-105.
2007: Joo Myungsoo; Kwon Minjae; Sadikot Ruxana T; Kingsley Philip J; Marnett Lawrence J; Blackwell Timothy S; Peebles R Stokes; Urade Yoshihiro; Christman John W
Induction and function of lipocalin prostaglandin D synthase in host immunity.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2565-75.
2007: Vila Andrew; Rosengarth Anja; Piomelli Daniele; Cravatt Benjamin; Marnett Lawrence J
Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase.
Biochemistry 2007;46(33):9578-85.
2007: Wang Yazhen; Schnetz-Boutaud Nathalie C; Saleh Sam; Marnett Lawrence J; Stone Michael P
Bulge migration of the malondialdehyde OPdG DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Chemical research in toxicology 2007;20(8):1200-10.
2007: Prusakiewicz Jeffery J; Turman Melissa V; Vila Andrew; Ball Heather L; Al-Mestarihi Ahmad H; Di Marzo Vincenzo; Marnett Lawrence J
Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.
Archives of biochemistry and biophysics 2007;464(2):260-8.
2007: Jacobs Aaron T; Marnett Lawrence J
The future of toxicology--wrap up.
Chemical research in toxicology 2007;20(7):983-5.
2007: Felts Andrew S; Ji Chuan; Stafford Jennifer B; Crews Brenda C; Kingsley Philip J; Rouzer Carol A; Washington Mary Kay; Subbaramaiah Kotha; Siegel Brianna S; Young Shiu M; Dannenberg Andrew J; Marnett Lawrence J
Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology.
ACS chemical biology 2007;2(7):479-83.
2007: Blobaum Anna L; Marnett Lawrence J
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.
The Journal of biological chemistry 2007;282(22):16379-90.
2007: Rouzer Carol A; Ivanova Pavlina T; Byrne Mark O; Brown H Alex; Marnett Lawrence J
Lipid profiling reveals glycerophospholipid remodeling in zymosan-stimulated macrophages.
Biochemistry 2007;46(20):6026-42.
2007: Trostchansky Andrés; O'Donnell Valerie B; Goodwin Douglas C; Landino Lisa M; Marnett Lawrence J; Radi Rafael; Rubbo Homero
Interactions between nitric oxide and peroxynitrite during prostaglandin endoperoxide H synthase-1 catalysis: a free radical mechanism of inactivation.
Free radical biology & medicine 2007;42(7):1029-38.
2007: Blobaum Anna L; Marnett Lawrence J
Structural and functional basis of cyclooxygenase inhibition.
Journal of medicinal chemistry 2007;50(7):1425-41.
2007: Knutson Charles G; Akingbade Dapo; Crews Brenda C; Voehler Markus; Stec Donald F; Marnett Lawrence J
Metabolism in vitro and in vivo of the DNA base adduct, M1G.
Chemical research in toxicology 2007;20(3):550-7.
2007: Wang Haibin; Xie Huirong; Sun Xiaofei; Kingsley Philip J; Marnett Lawrence J; Cravatt Benjamin F; Dey Sudhansu K
Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation.
Prostaglandins & other lipid mediators 2007;83(1-2):62-74.
2007: Adams T B; McGowen M M; Williams M C; Cohen S M; Feron V J; Goodman J I; Marnett L J; Munro I C; Portoghese P S; Smith R L; Waddell W J
The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(2):171-201.
2007: Lindsley Craig W; Weaver David; Jones Carrie; Marnett Larry; Conn P Jeffrey
Preclinical drug discovery research and training at Vanderbilt.
ACS chemical biology 2007;2(1):17-20.
2007: Yu Ying; Fan Jinjin; Hui Yiqun; Rouzer Carol A; Marnett Lawrence J; Klein-Szanto Andres J; FitzGerald Garret A; Funk Colin D
Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality.
The Journal of biological chemistry 2007;282(2):1498-506.
2007: Kingsley Philip J; Marnett Lawrence J
LC-MS-MS analysis of neutral eicosanoids.
Methods in enzymology 2007;433():91-112.
2006: Rouzer Carol A; Ivanova Pavlina T; Byrne Mark O; Milne Stephen B; Marnett Lawrence J; Brown H Alex
Lipid profiling reveals arachidonate deficiency in RAW264.7 cells: Structural and functional implications.
Biochemistry 2006;45(49):14795-808.
2006: Anning Peter B; Coles Barbara; Morton Jonathan; Wang Haibin; Uddin Jashim; Morrow Jason D; Dey Sudhansu K; Marnett Lawrence J; O'Donnell Valerie B
Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors.
Blood 2006;108(13):4059-62.
2006: Wang Hao; Kozekov Ivan D; Kozekova Albena; Tamura Pamela J; Marnett Lawrence J; Harris Thomas M; Rizzo Carmelo J
Site-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a postsynthetic modification strategy.
Chemical research in toxicology 2006;19(11):1467-74.
2006: Druckova Alexandra; Marnett Lawrence J
Characterization of the amino acid adducts of the enedial derivative of teucrin A.
Chemical research in toxicology 2006;19(10):1330-40.
2006: Feng Zhaohui; Hu Wenwei; Marnett Lawrence J; Tang Moon-shong
Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair.
Mutation research 2006;601(1-2):125-36.
2006: Rouzer Carol A; Tranguch Susanne; Wang Haibin; Zhang Hao; Dey Sudhansu K; Marnett Lawrence J
Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2.
The Biochemical journal 2006;399(1):91-9.
2006: Wang Haibin; Xie Huirong; Guo Yong; Zhang Hao; Takahashi Toshifumi; Kingsley Philip J; Marnett Lawrence J; Das Sanjoy K; Cravatt Benjamin F; Dey Sudhansu K
Fatty acid amide hydrolase deficiency limits early pregnancy events.
The Journal of clinical investigation 2006;116(8):2122-31.
2006: Otteneder Michael B; Knutson Charles G; Daniels J Scott; Hashim Muhammed; Crews Brenda C; Remmel Rory P; Wang Hao; Rizzo Carmelo; Marnett Lawrence J
In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6665-9.
2006: West James D; Marnett Lawrence J
Endogenous reactive intermediates as modulators of cell signaling and cell death.
Chemical research in toxicology 2006;19(2):173-94.
2006: Muthian Gladson; Raikwar Himanshu P; Johnson Caroline; Rajasingh Johnson; Kalgutkar Amit; Marnett Lawrence J; Bright John J
COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis.
Journal of clinical immunology 2006;26(1):73-85.
2005: Kalgutkar Amit S; Crews Brenda C; Saleh Sam; Prudhomme Daniel; Marnett Lawrence J
Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors.
Bioorganic & medicinal chemistry 2005;13(24):6810-22.
2005: Rouzer Carol A; Marnett Lawrence J
Structural and functional differences between cyclooxygenases: fatty acid oxygenases with a critical role in cell signaling.
Biochemical and biophysical research communications 2005;338(1):34-44.
2005: West James D; Marnett Lawrence J
Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal.
Chemical research in toxicology 2005;18(11):1642-53.
2005: Van Sickle Marja D; Duncan Marnie; Kingsley Philip J; Mouihate Abdeslam; Urbani Paolo; Mackie Ken; Stella Nephi; Makriyannis Alexandros; Piomelli Daniele; Davison Joseph S; Marnett Lawrence J; Di Marzo Vincenzo; Pittman Quentin J; Patel Kamala D; Sharkey Keith A
Identification and functional characterization of brainstem cannabinoid CB2 receptors.
Science (New York, N.Y.) 2005;310(5746):329-32.
2005: Sander Miriam; Cadet Jean; Casciano Daniel A; Galloway Sheila M; Marnett Lawrence J; Novak Raymond F; Pettit Syril D; Preston R Julian; Skare Julie A; Williams Gary M; Van Houten Bennett; Gollapudi B Bhaskar
Proceedings of a workshop on DNA adducts: biological significance and applications to risk assessment Washington, DC, April 13-14, 2004.
Toxicology and applied pharmacology 2005;208(1):1-20.
2005: Kingsley Philip J; Rouzer Carol A; Saleh Samir; Marnett Lawrence J
Simultaneous analysis of prostaglandin glyceryl esters and prostaglandins by electrospray tandem mass spectrometry.
Analytical biochemistry 2005;343(2):203-11.
2005: Adams T B; Cohen S M; Doull J; Feron V J; Goodman J I; Marnett L J; Munro I C; Portoghese P S; Smith R L; Waddell W J; Wagner B M;
The FEMA GRAS assessment of hydroxy- and alkoxy-substituted benzyl derivatives used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1241-71.
2005: Adams T B; Cohen S M; Doull J; Feron V J; Goodman J I; Marnett L J; Munro I C; Portoghese P S; Smith R L; Waddell W J; Wagner B M;
The FEMA GRAS assessment of benzyl derivatives used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1207-40.
2005: Adams T B; Cohen S M; Doull J; Feron V J; Goodman J I; Marnett L J; Munro I C; Portoghese P S; Smith R L; Waddell W J; Wagner B M;
The FEMA GRAS assessment of phenethyl alcohol, aldehyde, acid, and related acetals and esters used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1179-206.
2005: Smith Robert L; Cohen Samuel M; Doull John; Feron Victor J; Goodman Jay I; Marnett Lawrence J; Munro Ian C; Portoghese Philip S; Waddell William J; Wagner Bernard M; Adams Timothy B;
Criteria for the safety evaluation of flavoring substances. The Expert Panel of the Flavor and Extract Manufacturers Association.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1141-77.
2005: Burleigh Michael E; Babaev Vladimir R; Patel Mayur B; Crews Brenda C; Remmel Rory P; Morrow Jason D; Oates John A; Marnett Lawrence J; Fazio Sergio; Linton Macrae F
Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice.
Biochemical pharmacology 2005;70(3):334-42.
2005: Rouzer Carol A; Marnett Lawrence J
Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus.
The Journal of biological chemistry 2005;280(29):26690-700.
2005: Guo Yong; Wang Haibin; Okamoto Yasuo; Ueda Natsuo; Kingsley Philip J; Marnett Lawrence J; Schmid Harald H O; Das Sanjoy K; Dey Sudhansu K
N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation.
The Journal of biological chemistry 2005;280(25):23429-32.
2005: Moth Christopher W; Prusakiewicz Jeffrey J; Marnett Larry J; Lybrand Terry P
Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1.
Journal of medicinal chemistry 2005;48(10):3613-20.
2005: Rouzer Carol A; Jacobs Aaron T; Nirodi Chetan S; Kingsley Philip J; Morrow Jason D; Marnett Lawrence J
RAW264.7 cells lack prostaglandin-dependent autoregulation of tumor necrosis factor-alpha secretion.
Journal of lipid research 2005;46(5):1027-37.
2005: VanderVeen Laurie A; Druckova Alexandra; Riggins James N; Sorrells Jennifer L; Guengerich F Peter; Marnett Lawrence J
Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct.
Biochemistry 2005;44(13):5024-33.
2005: West James D; Ji Chuan; Marnett Lawrence J
Modulation of DNA fragmentation factor 40 nuclease activity by poly(ADP-ribose) polymerase-1.
The Journal of biological chemistry 2005;280(15):15141-7.
2005: Vélez-Cruz Renier; Riggins James N; Daniels J Scott; Cai Hongliang; Guengerich F Peter; Marnett Lawrence J; Osheroff Neil
Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.
Biochemistry 2005;44(10):3972-81.
2005: Kadiiska M B; Gladen B C; Baird D D; Graham L B; Parker C E; Ames B N; Basu S; Fitzgerald G A; Lawson J A; Marnett L J; Morrow J D; Murray D M; Plastaras J; Roberts L J; Rokach J; Shigenaga M K; Sun J; Walter P B; Tomer K B; Barrett J C; Mason R P
Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning.
Free radical biology & medicine 2005;38(6):711-8.
2005: Kadiiska M B; Gladen B C; Baird D D; Germolec D; Graham L B; Parker C E; Nyska A; Wachsman J T; Ames B N; Basu S; Brot N; Fitzgerald G A; Floyd R A; George M; Heinecke J W; Hatch G E; Hensley K; Lawson J A; Marnett L J; Morrow J D; Murray D M; Plastaras J; Roberts L J; Rokach J; Shigenaga M K; Sohal R S; Sun J; Tice R R; Van Thiel D H; Wellner D; Walter P B; Tomer K B; Mason R P; Barrett J C
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?
Free radical biology & medicine 2005;38(6):698-710.
2005: Smith R L; Cohen S M; Doull J; Feron V J; Goodman J I; Marnett L J; Portoghese P S; Waddell W J; Wagner B M; Hall R L; Higley N A; Lucas-Gavin C; Adams T B
A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(3):345-63.
2005: Hata Aaron N; Lybrand Terry P; Marnett Lawrence J; Breyer Richard M
Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2.
Molecular pharmacology 2005;67(3):640-7.
2005: Clark Stephen R; Anning Peter B; Coffey Marcus J; Roberts Andrew G; Marnett Lawrence J; O'Donnell Valerie B
Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover.
The Biochemical journal 2005;385(Pt 3):815-21.
2004: Prusakiewicz Jeffery J; Felts Andrew S; Mackenzie Bonnie S; Marnett Lawrence J
Molecular basis of the time-dependent inhibition of cyclooxygenases by indomethacin.
Biochemistry 2004;43(49):15439-45.
2004: Wang Haibin; Guo Yong; Wang Dingzhi; Kingsley Philip J; Marnett Lawrence J; Das Sanjoy K; DuBois Raymond N; Dey Sudhansu K
Aberrant cannabinoid signaling impairs oviductal transport of embryos.
Nature medicine 2004;10(10):1074-80.
2004: Hashim Muhammed F; Riggins James N; Schnetz-Boutaud Nathalie; Voehler Markus; Stone Michael P; Marnett Lawrence J
In vitro bypass of malondialdehyde-deoxyguanosine adducts: differential base selection during extension by the Klenow fragment of DNA polymerase I is the critical determinant of replication outcome.
Biochemistry 2004;43(37):11828-35.
2004: Riggins James N; Pratt Derek A; Voehler Markus; Daniels J Scott; Marnett Lawrence J
Kinetics and mechanism of the general-acid-catalyzed ring-closure of the malondialdehyde-DNA adduct, N2-(3-oxo-1-propenyl)deoxyguanosine (N2OPdG-), to 3-(2'-Deoxy-beta-D-erythro-pentofuranosyl)pyrimido[1,2-alpha]purin- 10(3H)-one (M1dG).
Journal of the American Chemical Society 2004;126(34):10571-81.
2004: Rouzer Carol A; Kingsley Phillip J; Wang Haibin; Zhang Hao; Morrow Jason D; Dey Sudhansu K; Marnett Lawrence J
Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages.
The Journal of biological chemistry 2004;279(33):34256-68.
2004: Riggins James N; Daniels J Scott; Rouzer Carol A; Marnett Lawrence J
Kinetic and thermodynamic analysis of the hydrolytic ring-opening of the malondialdehyde-deoxyguanosine adduct, 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)- pyrimido[1,2-alpha]purin-10(3H)-one.
Journal of the American Chemical Society 2004;126(26):8237-43.
2004: Cline Susan D; Riggins James N; Tornaletti Silvia; Marnett Lawrence J; Hanawalt Philip C
Malondialdehyde adducts in DNA arrest transcription by T7 RNA polymerase and mammalian RNA polymerase II.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(19):7275-80.
2004: Smith R L; Adams T B; Cohen S M; Doull J; Feron V J; Goodman J I; Hall R L; Marnett L J; Portoghese P S; Waddell W J; Wagner B M
Safety evaluation of natural flavour complexes.
Toxicology letters 2004;149(1-3):197-207.
2004: West James D; Ji Chuan; Duncan Stephen T; Amarnath Venkataraman; Schneider Claus; Rizzo Carmelo J; Brash Alan R; Marnett Lawrence J
Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation.
Chemical research in toxicology 2004;17(4):453-62.
2004: Wang Hao; Marnett Lawrence J; Harris Thomas M; Rizzo Carmelo J
A novel synthesis of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine.
Chemical research in toxicology 2004;17(2):144-9.
2004: Nirodi Chaitanya S; Crews Brenda C; Kozak Kevin R; Morrow Jason D; Marnett Lawrence J
The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1840-5.
2004: Adams Timothy B; Cohen Samuel M; Doull John; Feron Victor J; Goodman Jay I; Marnett Lawrence J; Munro Ian C; Portoghese Philip S; Smith Robert L; Waddell William J; Wagner Bernard M
The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(2):157-85.
2004: Hoberg Anne-Mette; Otteneder Michael; Marnett Lawrence J; Poulsen Henrik E
Measurement of the malondialdehyde-2'-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS 2004;39(1):38-42.
2004: Remmel Rory P; Crews Brenda C; Kozak Kevin R; Kalgutkar Amit S; Marnett Lawrence J;
Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(1):113-22.
2004: Kozak Kevin R; Prusakiewicz Jeffery J; Marnett Lawrence J
Oxidative metabolism of endocannabinoids by COX-2.
Current pharmaceutical design 2004;10(6):659-67.
2003: VanderVeen Laurie A; Hashim Muhammed F; Shyr Yu; Marnett Lawrence J
Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14247-52.
2003: Rowlinson Scott W; Kiefer James R; Prusakiewicz Jeffery J; Pawlitz Jennifer L; Kozak Kevin R; Kalgutkar Amit S; Stallings William C; Kurumbail Ravi G; Marnett Lawrence J
A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.
The Journal of biological chemistry 2003;278(46):45763-9.
2003: Kozak Kevin R; Prusakiewicz Jeffery J; Rowlinson Scott W; Prudhomme Daniel R; Marnett Lawrence J
Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide.
Biochemistry 2003;42(30):9041-9.
2003: Yu Zheyong; Schneider Claus; Boeglin William E; Marnett Lawrence J; Brash Alan R
The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9162-7.
2003: Niedernhofer Laura J; Daniels J Scott; Rouzer Carol A; Greene Rachel E; Marnett Lawrence J
Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells.
The Journal of biological chemistry 2003;278(33):31426-33.
2003: Rouzer Carol A; Marnett Lawrence J
Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases.
Chemical reviews 2003;103(6):2239-304.
2003: Pereira Cândida F; Paridaen Judith T M L; Rutten Karla; Huigen Marleen C D G; van de Bovenkamp Marja; Middel Jeena; Beerens Nancy; Berkhout Ben; Schuurman Rob; Marnett Lawrence J; Verhoef Jan; Nottet Hans S L M
Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication.
Antiviral research 2003;58(3):253-63.
2003: Otteneder Michael; Scott Daniels J; Voehler Markus; Marnett Lawrence J
Development of a method for determination of the malondialdehyde-deoxyguanosine adduct in urine using liquid chromatography-tandem mass spectrometry.
Analytical biochemistry 2003;315(2):147-51.
2003: Kingsley Philip J; Marnett Lawrence J
Analysis of endocannabinoids by Ag+ coordination tandem mass spectrometry.
Analytical biochemistry 2003;314(1):8-15.
2003: Marnett Lawrence J; Riggins James N; West James D
Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein.
The Journal of clinical investigation 2003;111(5):583-93.
2003: Aronoff David M; Boutaud Olivier; Marnett Lawrence J; Oates John A
Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.
The Journal of pharmacology and experimental therapeutics 2003;304(2):589-95.
2003: Phillip Hochgesang G; Nemeth-Cawley Jennifer F; Rowlinson Scott W; Caprioli Richard M; Marnett Lawrence J
Functional analysis of the molecular determinants of cyclooxygenase-2 acetylation by 2-acetoxyphenylhept-2-ynyl sulfide.
Archives of biochemistry and biophysics 2003;409(1):127-33.
2003: Aronoff David M; Boutaud Olivier; Marnett Lawrence J; Oates John A
Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.
Advances in experimental medicine and biology 2003;525():125-8.
2002: Marnett Lawrence J
Oxy radicals, lipid peroxidation and DNA damage.
Toxicology 2002;181-182():219-22.
2002: Kozak Kevin R; Crews Brenda C; Morrow Jason D; Wang Lee-Ho; Ma Y Henry; Weinander Rolf; Jakobsson Per-Johan; Marnett Lawrence J
Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides.
The Journal of biological chemistry 2002;277(47):44877-85.
2002: Rouzer Carol A; Ghebreselasie Kebreab; Marnett Lawrence J
Chemical stability of 2-arachidonylglycerol under biological conditions.
Chemistry and physics of lipids 2002;119(1-2):69-82.
2002: Marnett Lawrence J
Recent developments in cyclooxygenase inhibition.
Prostaglandins & other lipid mediators 2002;68-69():153-64.
2002: Prusakiewicz Jeffery J; Kingsley Philip J; Kozak Kevin R; Marnett Lawrence J
Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2.
Biochemical and biophysical research communications 2002;296(3):612-7.
2002: Moody John S; Marnett Lawrence J
Kinetics of inhibition of leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid.
Biochemistry 2002;41(32):10297-303.
2002: Timofeevski Sergei L; Prusakiewicz Jeffery J; Rouzer Carol A; Marnett Lawrence J
Isoform-selective interaction of cyclooxygenase-2 with indomethacin amides studied by real-time fluorescence, inhibition kinetics, and site-directed mutagenesis.
Biochemistry 2002;41(30):9654-62.
2002: Smith R L; Adams T B; Doull J; Feron V J; Goodman J I; Marnett L J; Portoghese P S; Waddell W J; Wagner B M; Rogers A E; Caldwell J; Sipes I G
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(7):851-70.
2002: Kozak Kevin R; Gupta Rajnish A; Moody John S; Ji Chuan; Boeglin William E; DuBois Raymond N; Brash Alan R; Marnett Lawrence J
15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist.
The Journal of biological chemistry 2002;277(26):23278-86.
2002: Boutaud Olivier; Aronoff David M; Richardson Jacob H; Marnett Lawrence J; Oates John A
Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):7130-5.
2002: Kozak Kevin R; Prusakiewicz Jeffery J; Rowlinson Scott W; Marnett Lawrence J
Enantiospecific, selective cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(9):1315-8.
2002: Burleigh Michael E; Babaev Vladimir R; Oates John A; Harris Raymond C; Gautam Shiva; Riendeau Denis; Marnett Lawrence J; Morrow Jason D; Fazio Sergio; Linton MacRae F
Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice.
Circulation 2002;105(15):1816-23.
2002: Plastaras John P; Dedon Peter C; Marnett Lawrence J
Effects of DNA structure on oxopropenylation by the endogenous mutagens malondialdehyde and base propenal.
Biochemistry 2002;41(15):5033-42.
2002: Sekhar Konjeti R; Spitz Douglas R; Harris Stephanie; Nguyen Trung T; Meredith Michael J; Holt Jeffrey T; Gius David; Marnett Lawrence J; Summar Marshall L; Freeman Michael L;
Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.
Free radical biology & medicine 2002;32(7):650-62.
2002: Adams T B; Doull J; Feron V J; Goodman J I; Marnett L J; Munro I C; Newberne P M; Portoghese P S; Smith R L; Waddell W J; Wagner B M
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. Flavor and Extract Manufacturers Association.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(4):429-51.
2002: Otteneder Michael; Plastaras John P; Marnett Lawrence J
Reaction of malondialdehyde-DNA adducts with hydrazines-development of a facile assay for quantification of malondialdehyde equivalents in DNA.
Chemical research in toxicology 2002;15(3):312-8.
2002: Leuratti Chiara; Watson Mark A; Deag Eliot J; Welch Ailsa; Singh Rajinder; Gottschalg Elke; Marnett Lawrence J; Atkin Wendy; Day Nicholas E; Shuker David E G; Bingham Sheila A
Detection of malondialdehyde DNA adducts in human colorectal mucosa: relationship with diet and the presence of adenomas.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(3):267-73.
2002: Kozak K R; Marnett L J
Oxidative metabolism of endocannabinoids.
Prostaglandins, leukotrienes, and essential fatty acids 2002;66(2-3):211-20.
2002: Weisenseel Jason P; Reddy G Ramachandra; Marnett Lawrence J; Stone Michael P
Structure of the 1,N(2)-propanodeoxyguanosine adduct in a three-base DNA hairpin loop derived from a palindrome in the Salmonella typhimurium hisD3052 gene.
Chemical research in toxicology 2002;15(2):140-52.
2002: Weisenseel Jason P; Reddy G Ramachandra; Marnett Lawrence J; Stone Michael P
Structure of an oligodeoxynucleotide containing a 1,N(2)-propanodeoxyguanosine adduct positioned in a palindrome derived from the Salmonella typhimurium hisD3052 gene: Hoogsteen pairing at pH 5.2.
Chemical research in toxicology 2002;15(2):127-39.
2002: Kalgutkar Amit S; Rowlinson Scott W; Crews Brenda C; Marnett Lawrence J
Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(4):521-4.
2002: Schneider Claus; Boeglin William E; Prusakiewicz Jeffery J; Rowlinson Scott W; Marnett Lawrence J; Samel Nigulas; Brash Alan R
Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349.
The Journal of biological chemistry 2002;277(1):478-85.
2002: Gierse James; Kurumbail Ravi; Walker Mark; Hood Bill; Monahan Joe; Pawlitz Jennifer; Stegeman Rick; Stevens Anna; Kiefer Jim; Koboldt Carol; Moreland Kirby; Rowlinson Scott; Marnett Larry; Pierce Jennifer; Carter Jeff; Talley John; Isakson Peter; Seibert Karen
Mechanism of inhibition of novel COX-2 inhibitors.
Advances in experimental medicine and biology 2002;507():365-9.
2002: Marnett Lawrence J; DuBois Raymond N
COX-2: a target for colon cancer prevention.
Annual review of pharmacology and toxicology 2002;42():55-80.
2001: Kurumbail R G; Kiefer J R; Marnett L J
Cyclooxygenase enzymes: catalysis and inhibition.
Current opinion in structural biology 2001;11(6):752-60.
2001: Schnetz-Boutaud N C; Saleh S; Marnett L J; Stone M P
The exocyclic 1,N2-deoxyguanosine pyrimidopurinone M1G is a chemically stable DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Biochemistry 2001;40(51):15638-49.
2001: Riggins J N; Marnett L J
Mutagenicity of the malondialdehyde oligomerization products 2-(3'-oxo-1'-propenyl)-malondialdehyde and 2,4-dihydroxymethylene-3-(2,2-dimethoxyethyl)glutaraldehyde in Salmonella.
Mutation research 2001;497(1-2):153-7.
2001: Kozak K R; Crews B C; Ray J L; Tai H H; Morrow J D; Marnett L J
Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo.
The Journal of biological chemistry 2001;276(40):36993-8.
2001: Sharma R A; Gescher A; Plastaras J P; Leuratti C; Singh R; Gallacher-Horley B; Offord E; Marnett L J; Steward W P; Plummer S M
Cyclooxygenase-2, malondialdehyde and pyrimidopurinone adducts of deoxyguanosine in human colon cells.
Carcinogenesis 2001;22(9):1557-60.
2001: Ji C; Amarnath V; Pietenpol J A; Marnett L J
4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release.
Chemical research in toxicology 2001;14(8):1090-6.
2001: Singh R; Leuratti C; Josyula S; Sipowicz M A; Diwan B A; Kasprzak K S; Schut H A; Marnett L J; Anderson L M; Shuker D E
Lobe-specific increases in malondialdehyde DNA adduct formation in the livers of mice following infection with Helicobacter hepaticus.
Carcinogenesis 2001;22(8):1281-7.
2001: Kozak K R; Prusakiewicz J J; Rowlinson S W; Schneider C; Marnett L J
Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol.
The Journal of biological chemistry 2001;276(32):30072-7.
2001: Sharma R A; McLelland H R; Hill K A; Ireson C R; Euden S A; Manson M M; Pirmohamed M; Marnett L J; Gescher A J; Steward W P
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):1894-900.
2001: Boutaud O; Brame C J; Chaurand P; Li J; Rowlinson S W; Crews B C; Ji C; Marnett L J; Caprioli R M; Roberts L J; Oates J A
Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid.
Biochemistry 2001;40(23):6948-55.
2001: Schnetz-Boutaud N C; Chapeau M C; Marnett L J
Enzymatic synthesis of M(1)G-deoxyribose.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2001;Chapter 1():Unit1.2.
2001: Ji C; Kozak K R; Marnett L J
IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal.
The Journal of biological chemistry 2001;276(21):18223-8.
2001: Sharma R A; Ireson C R; Verschoyle R D; Hill K A; Williams M L; Leuratti C; Manson M M; Marnett L J; Steward W P; Gescher A
Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1452-8.
2001: Everett S M; Singh R; Leuratti C; White K L; Neville P; Greenwood D; Marnett L J; Schorah C J; Forman D; Shuker D; Axon A T
Levels of malondialdehyde-deoxyguanosine in the gastric mucosa: relationship with lipid peroxidation, ascorbic acid, and Helicobacter pylori.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(4):369-76.
2001: DeWeese T L; Hruszkewycz A M; Marnett L J
Oxidative stress in chemoprevention trials.
Urology 2001;57(4 Suppl 1):137-40.
2001: Marnett L J; Plastaras J P
Endogenous DNA damage and mutation.
Trends in genetics : TIG 2001;17(4):214-21.
2001: Fink S P; Marnett L J
The relative contribution of adduct blockage and DNA repair on template utilization during replication of 1,N2-propanodeoxyguanosine and pyrimido.
Mutation research 2001;485(3):209-18.
2001: Nemeth J F; Hochgesang G P; Marnett L J; Caprioli R M;
Characterization of the glycosylation sites in cyclooxygenase-2 using mass spectrometry.
Biochemistry 2001;40(10):3109-16.
2001: VanderVeen L A; Hashim M F; Nechev L V; Harris T M; Harris C M; Marnett L J
Evaluation of the mutagenic potential of the principal DNA adduct of acrolein.
The Journal of biological chemistry 2001;276(12):9066-70.
2001: Moody J S; Kozak K R; Ji C; Marnett L J
Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase.
Biochemistry 2001;40(4):861-6.
2001: Schnetz-Boutaud N C; Saleh S; Marnett L J; Stone M P
Structure of the malondialdehyde deoxyguanosine adduct M1G when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Advances in experimental medicine and biology 2001;500():513-6.
2001: Boutaud O; Li J; Chaurand P; Brame C J; Marnett L J; Roberts L J; Oates J A
Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins.
Advances in experimental medicine and biology 2001;500():133-7.
2000: Plastaras J P; Riggins J N; Otteneder M; Marnett L J
Reactivity and mutagenicity of endogenous DNA oxopropenylating agents: base propenals, malondialdehyde, and N(epsilon)-oxopropenyllysine.
Chemical research in toxicology 2000;13(12):1235-42.
2000: O'Donnell V B; Coles B; Lewis M J; Crews B C; Marnett L J; Freeman B A
Catalytic consumption of nitric oxide by prostaglandin H synthase-1 regulates platelet function.
The Journal of biological chemistry 2000;275(49):38239-44.
2000: Schnetz-Boutaud N; Daniels J S; Hashim M F; Scholl P; Burrus T; Marnett L J
Pyrimido[1,2-alpha]purin-10(3H)-one: a reactive electrophile in the genome.
Chemical research in toxicology 2000;13(10):967-70.
2000: Marnett L J
Cyclooxygenase mechanisms.
Current opinion in chemical biology 2000;4(5):545-52.
2000: Kozak K R; Rowlinson S W; Marnett L J
Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.
The Journal of biological chemistry 2000;275(43):33744-9.
2000: Kalgutkar A S; Marnett A B; Crews B C; Remmel R P; Marnett L J
Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.
Journal of medicinal chemistry 2000;43(15):2860-70.
2000: Lanzo C A; Sutin J; Rowlinson S; Talley J; Marnett L J
Fluorescence quenching analysis of the association and dissociation of a diarylheterocycle to cyclooxygenase-1 and cyclooxygenase-2: dynamic basis of cyclooxygenase-2 selectivity.
Biochemistry 2000;39(20):6228-34.
2000: Goodwin D C; Rowlinson S W; Marnett L J
Substitution of tyrosine for the proximal histidine ligand to the heme of prostaglandin endoperoxide synthase 2: implications for the mechanism of cyclooxygenase activation and catalysis.
Biochemistry 2000;39(18):5422-32.
2000: Kiefer J R; Pawlitz J L; Moreland K T; Stegeman R A; Hood W F; Gierse J K; Stevens A M; Goodwin D C; Rowlinson S W; Marnett L J; Stallings W C; Kurumbail R G
Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature 2000;405(6782):97-101.
2000: Marnett L J; Wright T L; Crews B C; Tannenbaum S R; Morrow J D
Regulation of prostaglandin biosynthesis by nitric oxide is revealed by targeted deletion of inducible nitric-oxide synthase.
The Journal of biological chemistry 2000;275(18):13427-30.
2000: Plastaras J P; Guengerich F P; Nebert D W; Marnett L J
Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde.
The Journal of biological chemistry 2000;275(16):11784-90.
2000: Rowlinson S W; Crews B C; Goodwin D C; Schneider C; Gierse J K; Marnett L J
Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete.
The Journal of biological chemistry 2000;275(9):6586-91.
2000: Marnett L J
Oxyradicals and DNA damage.
Carcinogenesis 2000;21(3):361-70.
2000: Schnetz-Boutaud N C; Mao H; Stone M P; Marnett L J
Synthesis of oligonucleotides containing the alkali-labile pyrimidopurinone adduct, M(1)G.
Chemical research in toxicology 2000;13(2):90-5.
2000: Kalgutkar A S; Crews B C; Rowlinson S W; Marnett A B; Kozak K R; Remmel R P; Marnett L J
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):925-30.
2000: Marnett L J
Structure, function and inhibition of cyclo-oxygenases.
Ernst Schering Research Foundation workshop 2000;(31):65-83.
1999: Valyi-Nagy T; Sidell K R; Marnett L J; Roberts L J; Dermody T S; Morrow J D; Montine T J
Divergence of brain prostaglandin H synthase activity and oxidative damage in mice with encephalitis.
Journal of neuropathology and experimental neurology 1999;58(12):1269-75.
1999: Richards K M; Moody J S; Marnett L J
Mechanism of inhibition of porcine leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid.
Biochemistry 1999;38(50):16529-38.
1999: Marnett L J; Kalgutkar A S
Cyclooxygenase 2 inhibitors: discovery, selectivity and the future.
Trends in pharmacological sciences 1999;20(11):465-9.
1999: Montine T J; Sidell K R; Crews B C; Markesbery W R; Marnett L J; Roberts L J; Morrow J D
Elevated CSF prostaglandin E2 levels in patients with probable AD.
Neurology 1999;53(7):1495-8.
1999: Mao H; Reddy G R; Marnett L J; Stone M P
Solution structure of an oligodeoxynucleotide containing the malondialdehyde deoxyguanosine adduct N2-(3-oxo-1-propenyl)-dG (ring-opened M1G) positioned in a (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Biochemistry 1999;38(41):13491-501.
1999: Daniel T O; Liu H; Morrow J D; Crews B C; Marnett L J
Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis.
Cancer research 1999;59(18):4574-7.
1999: Stevens J L; Marnett L J
Defining molecular toxicology: a perspective.
Chemical research in toxicology 1999;12(9):747-8.
1999: Johnson K A; Mierzwa M L; Fink S P; Marnett L J
MutS recognition of exocyclic DNA adducts that are endogenous products of lipid oxidation.
The Journal of biological chemistry 1999;274(38):27112-8.
1999: Rowlinson S W; Crews B C; Lanzo C A; Marnett L J
The binding of arachidonic acid in the cyclooxygenase active site of mouse prostaglandin endoperoxide synthase-2 (COX-2). A putative L-shaped binding conformation utilizing the top channel region.
The Journal of biological chemistry 1999;274(33):23305-10.
1999: Marnett L J; Rowlinson S W; Goodwin D C; Kalgutkar A S; Lanzo C A
Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition.
The Journal of biological chemistry 1999;274(33):22903-6.
1999: Goodwin D C; Landino L M; Marnett L J
Effects of nitric oxide and nitric oxide-derived species on prostaglandin endoperoxide synthase and prostaglandin biosynthesis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(10):1121-36.
1999: Mao H; Schnetz-Boutaud N C; Weisenseel J P; Marnett L J; Stone M P
Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6615-20.
1999: Marnett L J
Lipid peroxidation-DNA damage by malondialdehyde.
Mutation research 1999;424(1-2):83-95.
1999: Goodwin D C; Landino L M; Marnett L J
Reactions of prostaglandin endoperoxide synthase with nitric oxide and peroxynitrite.
Drug metabolism reviews 1999;31(1):273-94.
1999: Li L; Zhu Z; Joshi B; Zhang C; Johnson C R; Marnett L J; Honn K V; Crissman J D; Porter A T; Tang D G
A novel hydroxamic acid compound, BMD188, demonstrates anti-prostate cancer effects by inducing apoptosis. II: In vivo efficacy and pharmacokinetic studies.
Anticancer research 1999;19(1A):61-9.
1999: Kalgutkar A S; Crews B C; Rowlinson S W; Garner C; Marnett L J
Discovery of a new class of selective cyclooxygenase-2 (COX-2) inhibitor that covalently modifies the isozyme.
Advances in experimental medicine and biology 1999;469():139-43.
1999: Leuratti C; Singh R; Deag E J; Griech E; Hughes R; Bingham S A; Plastaras J P; Marnett L J; Shuker D E
A sensitive immunoslot-blot assay for detection of malondialdehyde-deoxyguanosine in human DNA.
IARC scientific publications 1999;(150):197-203.
1999: Marnett L J
Chemistry and biology of DNA damage by malondialdehyde.
IARC scientific publications 1999;(150):17-27.
1998: Leuratti C; Singh R; Lagneau C; Farmer P B; Plastaras J P; Marnett L J; Shuker D E
Determination of malondialdehyde-induced DNA damage in human tissues using an immunoslot blot assay.
Carcinogenesis 1998;19(11):1919-24.
1998: Kalgutkar A S; Kozak K R; Crews B C; Hochgesang G P; Marnett L J
Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.
Journal of medicinal chemistry 1998;41(24):4800-18.
1998: Kadlubar F F; Anderson K E; Häussermann S; Lang N P; Barone G W; Thompson P A; MacLeod S L; Chou M W; Mikhailova M; Plastaras J; Marnett L J; Nair J; Velic I; Bartsch H
Comparison of DNA adduct levels associated with oxidative stress in human pancreas.
Mutation research 1998;405(2):125-33.
1998: Dedon P C; Plastaras J P; Rouzer C A; Marnett L J
Indirect mutagenesis by oxidative DNA damage: formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11113-6.
1998: Marnett L J; Kalgutkar A S
Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents.
Current opinion in chemical biology 1998;2(4):482-90.
1998: Ji C; Rouzer C A; Marnett L J; Pietenpol J A
Induction of cell cycle arrest by the endogenous product of lipid peroxidation, malondialdehyde.
Carcinogenesis 1998;19(7):1275-83.
1998: Marnett L J
Forum: reactive species of peroxynitrite.
Chemical research in toxicology 1998;11(7):709.
1998: Kalgutkar A S; Crews B C; Rowlinson S W; Garner C; Seibert K; Marnett L J
Aspirin-like molecules that covalently inactivate cyclooxygenase-2.
Science (New York, N.Y.) 1998;280(5367):1268-70.
1998: Langouët S; Mican A N; Müller M; Fink S P; Marnett L J; Muhle S A; Guengerich F P
Misincorporation of nucleotides opposite five-membered exocyclic ring guanine derivatives by escherichia coli polymerases in vitro and in vivo: 1,N2-ethenoguanine, 5,6,7,9-tetrahydro-9-oxoimidazo[1, 2-a]purine, and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1, 2-a]purine.
Biochemistry 1998;37(15):5184-93.
1998: Goodwin D C; Gunther M R; Hsi L C; Crews B C; Eling T E; Mason R P; Marnett L J
Nitric oxide trapping of tyrosyl radicals generated during prostaglandin endoperoxide synthase turnover. Detection of the radical derivative of tyrosine 385.
The Journal of biological chemistry 1998;273(15):8903-9.
1998: Lanzo C A; Beechem J M; Talley J; Marnett L J
Investigation of the binding of isoform-selective inhibitors to prostaglandin endoperoxide synthases using fluorescence spectroscopy.
Biochemistry 1998;37(1):217-26.
1998: Tang D G; Li L; Zhu Z; Joshi B; Johnson C R; Marnett L J; Honn K V; Crissman J D; Krajewski S; Reed J C; Timar J; Porter A T
BMD188, A novel hydroxamic acid compound, demonstrates potent anti-prostate cancer effects in vitro and in vivo by inducing apoptosis: requirements for mitochondria, reactive oxygen species, and proteases.
Pathology oncology research : POR 1998;4(3):179-90.
1997: Ji C; Marnett L J; Pietenpol J A
Cell cycle re-entry following chemically-induced cell cycle synchronization leads to elevated p53 and p21 protein levels.
Oncogene 1997;15(22):2749-53.
1997: Landino L M; Crews B C; Gierse J K; Hauser S D; Marnett L J
Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation.
The Journal of biological chemistry 1997;272(34):21565-74.
1997: Hashim M F; Schnetz-Boutaud N; Marnett L J
Replication of template-primers containing propanodeoxyguanosine by DNA polymerase beta. Induction of base pair substitution and frameshift mutations by template slippage and deoxynucleoside triphosphate stabilization.
The Journal of biological chemistry 1997;272(32):20205-12.
1997: Fink S P; Reddy G R; Marnett L J
Mutagenicity in Escherichia coli of the major DNA adduct derived from the endogenous mutagen malondialdehyde.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8652-7.
1997: Gunther M R; Hsi L C; Curtis J F; Gierse J K; Marnett L J; Eling T E; Mason R P
Nitric oxide trapping of the tyrosyl radical of prostaglandin H synthase-2 leads to tyrosine iminoxyl radical and nitrotyrosine formation.
The Journal of biological chemistry 1997;272(27):17086-90.
1997: Richards K M; Marnett L J
Leukocyte 12-lipoxygenase: expression, purification, and investigation of the role of methionine residues in turnover-dependent inactivation and 5,8,11,14-eicosatetraynoic acid inhibition.
Biochemistry 1997;36(22):6692-9.
1997: Niedernhofer L J; Riley M; Schnetz-Boutaud N; Sanduwaran G; Chaudhary A K; Reddy G R; Marnett L J
Temperature-dependent formation of a conjugate between tris(hydroxymethyl)aminomethane buffer and the malondialdehyde-DNA adduct pyrimidopurinone.
Chemical research in toxicology 1997;10(5):556-61.
1997: Marnett L J
Free radical mechanisms of neurotoxicity.
Chemical research in toxicology 1997;10(5):483-4.
1997: Johnson K A; Fink S P; Marnett L J
Repair of propanodeoxyguanosine by nucleotide excision repair in vivo and in vitro.
The Journal of biological chemistry 1997;272(17):11434-8.
1997: Rouzer C A; Chaudhary A K; Nokubo M; Ferguson D M; Reddy G R; Blair I A; Marnett L J
Analysis of the malondialdehyde-2'-deoxyguanosine adduct pyrimidopurinone in human leukocyte DNA by gas chromatography/electron capture/negative chemical ionization/mass spectrometry.
Chemical research in toxicology 1997;10(2):181-8.
1997: Sevilla C L; Mahle N H; Eliezer N; Uzieblo A; O'Hara S M; Nokubo M; Miller R; Rouzer C A; Marnett L J
Development of monoclonal antibodies to the malondialdehyde-deoxyguanosine adduct, pyrimidopurinone.
Chemical research in toxicology 1997;10(2):172-80.
1997: Smith C J; Morrow J D; Roberts L J; Marnett L J
Induction of prostaglandin endoperoxide synthase-1 (COX-1) in a human promonocytic cell line by treatment with the differentiating agent TPA.
Advances in experimental medicine and biology 1997;400A():99-106.
1997: Kalgutkar A S; Crews B C; Marnett L J
Inactivation of prostaglandin endoperoxide synthase (PGHS) by N-(substituted)maleimides.
Advances in experimental medicine and biology 1997;407():79-85.
1996: Landino L M; Crews B C; Timmons M D; Morrow J D; Marnett L J
Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15069-74.
1996: Gorins G; Kuhnert L; Johnson C R; Marnett L J
(Carboxyalkyl)benzyl propargyl ethers as selective inhibitors of leukocyte-type 12-lipoxygenases.
Journal of medicinal chemistry 1996;39(25):4871-8.
1996: Smith C J; Marnett L J
Effects of cysteine-to-serine mutations on structural and functional properties of prostaglandin endoperoxide synthase.
Archives of biochemistry and biophysics 1996;335(2):342-50.
1996: Marnett L J
Nitric oxide: chemical events in toxicity.
Chemical research in toxicology 1996;9(5):807-8.
1996: Kalgutkar A S; Crews B C; Marnett L J
Kinetics of the interaction of nonsteroidal antiinflammatory drugs with prostaglandin endoperoxide synthase-1 studied by limited proteolysis.
Biochemistry 1996;35(28):9076-82.
1996: Chaudhary A K; Reddy G R; Blair I A; Marnett L J
Characterization of an N6-oxopropenyl-2'-deoxyadenosine adduct in malondialdehyde-modified DNA using liquid chromatography/electrospray ionization tandem mass spectrometry.
Carcinogenesis 1996;17(5):1167-70.
1996: Kalgutkar A S; Crews B C; Marnett L J
Design, synthesis, and biochemical evaluation of N-substituted maleimides as inhibitors of prostaglandin endoperoxide synthases.
Journal of medicinal chemistry 1996;39(8):1692-703.
1996: Hashim M F; Marnett L J
Sequence-dependent induction of base pair substitutions and frameshifts by propanodeoxyguanosine during in vitro DNA replication.
The Journal of biological chemistry 1996;271(15):9160-5.
1996: Landino L M; Marnett L J
Mechanism of hydroperoxide reduction by mangano-prostaglandin endoperoxide synthase.
Biochemistry 1996;35(8):2637-43.
1996: Fink S P; Reddy G R; Marnett L J
Relative contribution of cytosine deamination and error-prone replication to the induction of propanodeoxyguanosine-->deoxyadenosine mutations in Escherichia coli.
Chemical research in toxicology 1996;9(1):277-83.
1996: Reddy G R; Marnett L J
Mechanism of reaction of beta-(aryloxy)acroleins with nucleosides.
Chemical research in toxicology 1996;9(1):12-5.
1996: Marnett L J
Creation of the probationary division of chemical toxicology.
Chemical research in toxicology 1996;9(1):1-2.
1995: Kingma P S; Corbett A H; Burcham P C; Marnett L J; Osheroff N
Abasic sites stimulate double-stranded DNA cleavage mediated by topoisomerase II. DNA lesions as endogenous topoisomerase II poisons.
The Journal of biological chemistry 1995;270(37):21441-4.
1995: Marnett L J
Report on the monitoring study of Chemical Research in Toxicology.
Chemical research in toxicology 1995;8(4):479-80.
1995: Marnett L J
Aspirin and related nonsteroidal anti-inflammatory drugs as chemopreventive agents against colon cancer.
Preventive medicine 1995;24(2):103-6.
1995: Benamira M; Johnson K; Chaudhary A; Bruner K; Tibbetts C; Marnett L J
Induction of mutations by replication of malondialdehyde-modified M13 DNA in Escherichia coli: determination of the extent of DNA modification, genetic requirements for mutagenesis, and types of mutations induced.
Carcinogenesis 1995;16(1):93-9.
1995: Weisenseel J P; Moe J G; Reddy G R; Marnett L J; Stone M P
Structure of a duplex oligodeoxynucleotide containing propanodeoxyguanosine opposite a two-base deletion in the (CpG)3 frame shift hotspot of Salmonella typhimurium hisD3052 determined by 1H NMR and restrained molecular dynamics.
Biochemistry 1995;34(1):50-64.
1995: Marnett L J; Wilcox A L
The chemistry of lipid alkoxyl radicals and their role in metal-amplified lipid peroxidation.
Biochemical Society symposium 1995;61():65-72.
1994: Beckman J K; Bagheri F; Ji C; Blair I A; Marnett L J
Phospholipid peroxidation in tumor promoter-exposed mouse skin.
Carcinogenesis 1994;15(12):2937-44.
1994: Marnett L J
Generation of mutagens during arachidonic acid metabolism.
Cancer metastasis reviews 1994;13(3-4):303-8.
1994: Marnett L J; Honn K V
Overview of articles on eicosanoids and cancer.
Cancer metastasis reviews 1994;13(3-4):237-9.
1994: Reddy R G; Yoshimoto T; Yamamoto S; Marnett L J
Expression, purification, and characterization of porcine leukocyte 12-lipoxygenase produced in the methylotrophic yeast, Pichia pastoris.
Biochemical and biophysical research communications 1994;205(1):381-8.
1994: Burcham P C; Marnett L J
Site-specific mutagenesis by a propanodeoxyguanosine adduct carried on an M13 genome.
The Journal of biological chemistry 1994;269(46):28844-50.
1994: Kennedy T A; Smith C J; Marnett L J
Investigation of the role of cysteines in catalysis by prostaglandin endoperoxide synthase.
The Journal of biological chemistry 1994;269(44):27357-64.
1994: Heath C W; Thun M J; Greenberg E R; Levin B; Marnett L J
Nonsteroidal antiinflammatory drugs and human cancer. Report of an interdisciplinary research workshop.
Cancer 1994;74(10):2885-8.
1994: Chaudhary A K; Nokubo M; Reddy G R; Yeola S N; Morrow J D; Blair I A; Marnett L J
Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver.
Science (New York, N.Y.) 1994;265(5178):1580-2.
1994: Chaudhary A K; Nokubo M; Marnett L J; Blair I A
Analysis of the malondialdehyde-2'-deoxyguanosine adduct in rat liver DNA by gas chromatography/electron capture negative chemical ionization mass spectrometry.
Biological mass spectrometry 1994;23(8):457-64.
1994: Kalgutkar A S; Marnett L J
Rapid inactivation of prostaglandin endoperoxide synthases by N-(carboxyalkyl)maleimides.
Biochemistry 1994;33(29):8625-8.
1994: Reddy R G; Yoshimoto T; Yamamoto S; Funk C D; Marnett L J
Expression of porcine leukocyte 12-lipoxygenase in a baculovirus/insect cell system and its characterization.
Archives of biochemistry and biophysics 1994;312(1):219-26.
1994: Moe J G; Reddy G R; Marnett L J; Stone M P
1H NMR characterization of a duplex oligodeoxynucleotide containing propanodeoxyguanosine opposite a two-base deletion in the (CpG)3 frameshift hotspot of Salmonella typhimurium hisD3052.
Chemical research in toxicology 1994;7(3):319-28.
1994: Helzlsouer K J; Block G; Blumberg J; Diplock A T; Levine M; Marnett L J; Schulplein R J; Spence J T; Simic M G
Summary of the round table discussion on strategies for cancer prevention: diet, food, additives, supplements, and drugs.
Cancer research 1994;54(7 Suppl):2044s-2051s.
1994: Marnett L J; Ji C
Modulation of oxidant formation in mouse skin in vivo by tumor-promoting phorbol esters.
Cancer research 1994;54(7 Suppl):1886s-1889s.
1994: Liu B; Marnett L J; Chaudhary A; Ji C; Blair I A; Johnson C R; Diglio C A; Honn K V
Biosynthesis of 12(S)-hydroxyeicosatetraenoic acid by B16 amelanotic melanoma cells is a determinant of their metastatic potential.
Laboratory investigation; a journal of technical methods and pathology 1994;70(3):314-23.
1994: Chen Y Q; Duniec Z M; Liu B; Hagmann W; Gao X; Shimoji K; Marnett L J; Johnson C R; Honn K V
Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.
Cancer research 1994;54(6):1574-9.
1994: Marnett L J
DNA adducts of alpha,beta-unsaturated aldehydes and dicarbonyl compounds.
IARC scientific publications 1994;(125):151-63.
1993: Singh U S; Moe J G; Reddy G R; Weisenseel J P; Marnett L J; Stone M P
1H NMR of an oligodeoxynucleotide containing a propanodeoxyguanosine adduct positioned in a (CG)3 frameshift hotspot of Salmonella typhimurium hisD3052: Hoogsteen base-pairing at pH 5.8.
Chemical research in toxicology 1993;6(6):825-36.
1993: Marnett L J; Burcham P C
Endogenous DNA adducts: potential and paradox.
Chemical research in toxicology 1993;6(6):771-85.
1993: Wilcox A L; Marnett L J
Polyunsaturated fatty acid alkoxyl radicals exist as carbon-centered epoxyallylic radicals: a key step in hydroperoxide-amplified lipid peroxidation.
Chemical research in toxicology 1993;6(4):413-6.
1993: Benamira M; Marnett L J
Construction of a vector for site-specific frameshift mutagenesis containing the mutable hotspot of Salmonella typhimurium TA98 on an M13 bacteriophage.
Chemical research in toxicology 1993;6(3):317-27.
1993: Smith C J; Morrow J D; Roberts L J; Marnett L J
Differentiation of monocytoid THP-1 cells with phorbol ester induces expression of prostaglandin endoperoxide synthase-1 (COX-1).
Biochemical and biophysical research communications 1993;192(2):787-93.
1993: Wells I; Marnett L J
Inactivation of prostaglandin endoperoxide synthase by acylating derivatives of indomethacin.
Biochemistry 1993;32(10):2710-6.
1993: Blée E; Wilcox A L; Marnett L J; Schuber F
Mechanism of reaction of fatty acid hydroperoxides with soybean peroxygenase.
The Journal of biological chemistry 1993;268(3):1708-15.
1992: Jajoo H K; Burcham P C; Goda Y; Blair I A; Marnett L J
A thermospray liquid chromatography/mass spectrometry method for analysis of human urine for the major malondialdehyde-guanine adduct.
Chemical research in toxicology 1992;5(6):870-5.
1992: Marnett L J
Of mice and men: human risk assessment based on high-dose rodent exposure.
Chemical research in toxicology 1992;5(6):735-6.
1992: Benamira M; Singh U; Marnett L J
Site-specific frameshift mutagenesis by a propanodeoxyguanosine adduct positioned in the (CpG)4 hot-spot of Salmonella typhimurium hisD3052 carried on an M13 vector.
The Journal of biological chemistry 1992;267(31):22392-400.
1992: Benamira M; Marnett L J
The lipid peroxidation product 4-hydroxynonenal is a potent inducer of the SOS response.
Mutation research 1992;293(1):1-10.
1992: DeGray J A; Lassmann G; Curtis J F; Kennedy T A; Marnett L J; Eling T E; Mason R P
Spectral analysis of the protein-derived tyrosyl radicals from prostaglandin H synthase.
The Journal of biological chemistry 1992;267(33):23583-8.
1992: Marnett L J
Aspirin and the potential role of prostaglandins in colon cancer.
Cancer research 1992;52(20):5575-89.
1992: Wells I; Marnett L J
Acetylation of prostaglandin endoperoxide synthase by N-acetylimidazole: comparison to acetylation by aspirin.
Biochemistry 1992;31(40):9520-5.
1992: Ji C; Marnett L J
Oxygen radical-dependent epoxidation of (7S,8S)-dihydroxy-7,8-dihydrobenzo[a]pyrene in mouse skin in vivo. Stimulation by phorbol esters and inhibition by antiinflammatory steroids.
The Journal of biological chemistry 1992;267(25):17842-8.
1992: Odenwaller R; Maddipati K R; Marnett L J
Detection of a higher oxidation state of manganese-prostaglandin endoperoxide synthase.
The Journal of biological chemistry 1992;267(20):13863-9.
1992: Pal I; Odenwaller R; Marnett L J
7-Oxabicycloheptylprostanoic acids: potent, time-dependent cyclooxygenase inhibitors that induce a conformational change in the prostaglandin endoperoxide synthase protein.
Journal of medicinal chemistry 1992;35(12):2340-2.
1992: Smith W L; Eling T E; Kulmacz R J; Marnett L J; Tsai A
Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase.
Biochemistry 1992;31(1):3-7.
1992: Reddy A P; Pruess-Schwartz D; Ji C; Gorycki P; Marnett L J
32P-postlabeling analysis of DNA adduction in mouse skin following topical administration of (+)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene.
Chemical research in toxicology 1992;5(1):26-33.
1992: Reddy A P; Pruess-Schwartz D; Marnett L J
Separation of (+)-syn- and (-)-anti-benzo[a]pyrene dihydrodiol epoxide-DNA adducts in 32P-postlabeling analysis.
Chemical research in toxicology 1992;5(1):19-25.
1991: Chapeau M C; Marnett L J
Enzymatic synthesis of purine deoxynucleoside adducts.
Chemical research in toxicology 1991;4(6):636-8.
1991: Lassmann G; Odenwaller R; Curtis J F; DeGray J A; Mason R P; Marnett L J; Eling T E
Electron spin resonance investigation of tyrosyl radicals of prostaglandin H synthase. Relation to enzyme catalysis.
The Journal of biological chemistry 1991;266(30):20045-55.
1991: Goda Y; Marnett L J
High-performance liquid chromatography with electrochemical detection for determination of the major malondialdehyde-guanine adduct.
Chemical research in toxicology 1991;4(5):520-4.
1991: Smith W L; Marnett L J
Prostaglandin endoperoxide synthase: structure and catalysis.
Biochimica et biophysica acta 1991;1083(1):1-17.
1991: O'Hara S M; Marnett L J
DNA sequence analysis of spontaneous and beta-methoxy-acrolein-induced mutations in Salmonella typhimurium hisD3052.
Mutation research 1991;247(1):45-56.
1991: Marnett L J
Peroxyl free radicals: biological reactive intermediates produced during lipid oxidation.
Advances in experimental medicine and biology 1991;283():65-70.
1991: Smith W L; Marnett L J; DeWitt D L
Prostaglandin and thromboxane biosynthesis.
Pharmacology & therapeutics 1991;49(3):153-79.
1991: Odenwaller R; O'Gara C Y; Marnett L J
Properties of trypsin-cleaved PGH synthase.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():81-4.
1991: Marnett L J; Leithauser M T; Richards K M; Blair I; Honn K V; Yamamoto S; Yoshimoto T
Arachidonic acid metabolism of cytosolic fractions of Lewis lung carcinoma cells.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21B():895-900.
1990: Sarkar F H; Radcliff G; Callewaert D M; Marnett L J; Eling T; Daston D S; Caspary W J
Mutagenic response of mouse lymphoma cells after activation of benzidine and 2-aminofluorene with purified prostaglandin H synthase.
Mutation research 1990;242(4):319-28.
1990: Stone K; Uzieblo A; Marnett L J
Studies of the reaction of malondialdehyde with cytosine nucleosides.
Chemical research in toxicology 1990;3(5):467-72.
1990: Marnett L J
Prostaglandin synthase-mediated metabolism of carcinogens and a potential role for peroxyl radicals as reactive intermediates.
Environmental health perspectives 1990;88():5-12.
1990: Laudicina D C; Marnett L J
Enhancement of hydroperoxide-dependent lipid peroxidation in rat liver microsomes by ascorbic acid.
Archives of biochemistry and biophysics 1990;278(1):73-80.
1990: Stone K; Ksebati M B; Marnett L J
Investigation of the adducts formed by reaction of malondialdehyde with adenosine.
Chemical research in toxicology 1990;3(1):33-8.
1990: Samokyszyn V M; Marnett L J
Inhibition of liver microsomal lipid peroxidation by 13-cis-retinoic acid.
Free radical biology & medicine 1990;8(5):491-6.
1990: Marnett L J; Reddy A; Pruess-Schwartz D; Ji C
Oxidation of polycyclic hydrocarbons by oxygen radicals.
Princess Takamatsu symposia 1990;21():63-73.
1990: Odenwaller R; Chen Y N; Marnett L J
Preparation and proteolytic cleavage of apoprostaglandin endoperoxide synthase.
Methods in enzymology 1990;187():479-85.
1990: Samokyszyn V M; Marnett L J
Inhibition of microsomal lipid peroxidation by 13-cis-retinoic acid.
Methods in enzymology 1990;190():281-8.
1989: Shimada T; Martin M V; Pruess-Schwartz D; Marnett L J; Guengerich F P
Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.
Cancer research 1989;49(22):6304-12.
1989: O'Gara C Y; Maddipati K R; Marnett L J
A sensitive electrochemical method for quantitative hydroperoxide determination.
Chemical research in toxicology 1989;2(5):295-300.
1989: Chen Y N; Marnett L J
Heme prosthetic group required for acetylation of prostaglandin H synthase by aspirin.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(11):2294-7.
1989: Plé P; Marnett L J
Alkylaryl sulfides as peroxidase reducing substrates for prostaglandin H synthase. Probes for the reactivity and environment of the ferryl-oxo complex.
The Journal of biological chemistry 1989;264(24):13983-93.
1989: Pruess-Schwartz D; Nimesheim A; Marnett L J
Peroxyl radical- and cytochrome P-450-dependent metabolic activation of (+)-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in mouse skin in vitro and in vivo.
Cancer research 1989;49(7):1732-7.
1989: Marnett L J; Chen Y N; Maddipati K R; Labeque R; Ple P
Localization of the peroxidase active site of PGH synthase.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():458-61.
1988: Marnett L J; Chen Y N; Maddipati K R; Plé P; Labèque R
Functional differentiation of cyclooxygenase and peroxidase activities of prostaglandin synthase by trypsin treatment. Possible location of a prosthetic heme binding site.
The Journal of biological chemistry 1988;263(32):16532-5.
1988: Padbury G; Sligar S G; Labeque R; Marnett L J
Ferric bleomycin catalyzed reduction of 10-hydroperoxy-8,12-octadecadienoic acid: evidence for homolytic O-O bond scission.
Biochemistry 1988;27(20):7846-52.
1988: Labeque R; Marnett L J
Reaction of hematin with allylic fatty acid hydroperoxides: identification of products and implications for pathways of hydroperoxide-dependent epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene.
Biochemistry 1988;27(18):7060-70.
1988: O'Brian C A; Ward N E; Weinstein I B; Bull A W; Marnett L J
Activation of rat brain protein kinase C by lipid oxidation products.
Biochemical and biophysical research communications 1988;155(3):1374-80.
1988: Chopra H; Hatfield J S; Chang Y S; Grossi I M; Fitzgerald L A; O'Gara C Y; Marnett L J; Diglio C A; Taylor J D; Honn K V
Role of tumor cytoskeleton and membrane glycoprotein IRGpIIb/IIIa in platelet adhesion to tumor cell membrane and tumor cell-induced platelet aggregation.
Cancer research 1988;48(13):3787-800.
1988: Bull A W; Nigro N D; Marnett L J
Structural requirements for stimulation of colonic cell proliferation by oxidized fatty acids.
Cancer research 1988;48(7):1771-6.
1988: Capdevila J; Gil L; Orellana M; Marnett L J; Mason J I; Yadagiri P; Falck J R
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.
Archives of biochemistry and biophysics 1988;261(2):257-63.
1988: Basu A K; O'Hara S M; Valladier P; Stone K; Mols O; Marnett L J
Identification of adducts formed by reaction of guanine nucleosides with malondialdehyde and structurally related aldehydes.
Chemical research in toxicology 1988;1(1):53-9.
1987: Maddipati K R; Marnett L J
Characterization of the major hydroperoxide-reducing activity of human plasma. Purification and properties of a selenium-dependent glutathione peroxidase.
The Journal of biological chemistry 1987;262(36):17398-403.
1987: Chen Y N; Bienkowski M J; Marnett L J
Controlled tryptic digestion of prostaglandin H synthase. Characterization of protein fragments and enhanced rate of proteolysis of oxidatively inactivated enzyme.
The Journal of biological chemistry 1987;262(35):16892-9.
1987: Menter D G; Steinert B W; Sloane B F; Gundlach N; O'Gara C Y; Marnett L J; Diglio C; Walz D; Taylor J D; Honn K V
Role of platelet membrane in enhancement of tumor cell adhesion to endothelial cell extracellular matrix.
Cancer research 1987;47(24 Pt 1):6751-62.
1987: Marnett L J
Peroxyl free radicals: potential mediators of tumor initiation and promotion.
Carcinogenesis 1987;8(10):1365-73.
1987: Samokyszyn V M; Marnett L J
Hydroperoxide-dependent cooxidation of 13-cis-retinoic acid by prostaglandin H synthase.
The Journal of biological chemistry 1987;262(29):14119-33.
1987: Markey C M; Alward A; Weller P E; Marnett L J
Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities.
The Journal of biological chemistry 1987;262(13):6266-79.
1987: Maddipati K R; Gasparski C; Marnett L J
Characterization of the hydroperoxide-reducing activity of human plasma.
Archives of biochemistry and biophysics 1987;254(1):9-17.
1987: Bull A W; Moghissi K; Wachsman K; Marnett L J
Copper-containing IUDs are not associated with an increase of malondialdehyde levels in cervical mucus.
Contraception 1987;35(1):49-55.
1987: Lambeir A M; Markey C M; Dunford H B; Marnett L J
Spectral properties of the higher oxidation states of prostaglandin H synthase.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17A():25-8.
1986: Eling T; Curtis J; Battista J; Marnett L J
Oxidation of (+)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by mouse keratinocytes: evidence for peroxyl radical- and monoxygenase-dependent metabolism.
Carcinogenesis 1986;7(12):1957-63.
1986: Dix T A; Buck J R; Marnett L J
Hydroperoxide-dependent epoxidation of 3,4-dihydroxy-3,4-dihydrobenzo[a]anthracene by ram seminal vesicle microsomes and by hematin.
Biochemical and biophysical research communications 1986;140(1):181-7.
1986: Marnett L J; Basu A K; O'Hara S M
The role of cyclic nucleic acid adducts in the mutational specificity of malondialdehyde and beta-substituted acroleins in Salmonella.
IARC scientific publications 1986;(70):175-83.
1985: Weller P E; Markey C M; Marnett L J
Enzymatic reduction of 5-phenyl-4-pentenyl-hydroperoxide: detection of peroxidases and identification of peroxidase reducing substrates.
Archives of biochemistry and biophysics 1985;243(2):633-43.
1985: Lambeir A M; Markey C M; Dunford H B; Marnett L J
Spectral properties of the higher oxidation states of prostaglandin H synthase.
The Journal of biological chemistry 1985;260(28):14894-6.
1985: Bull A W; Marnett L J
Determination of malondialdehyde by ion-pairing high-performance liquid chromatography.
Analytical biochemistry 1985;149(1):284-90.
1985: Marnett L J; Buck J; Tuttle M A; Basu A K; Bull A W
Distribution and oxidation of malondialdehyde in mice.
Prostaglandins 1985;30(2):241-54.
1985: Battista J R; Marnett L J
Prostaglandin H synthase-dependent epoxidation of aflatoxin B1.
Carcinogenesis 1985;6(8):1227-9.
1985: Honn K V; Marnett L J
Requirement of a reactive alpha, beta-unsaturated carbonyl for inhibition of tumor growth and induction of differentiation by "A" series prostaglandins.
Biochemical and biophysical research communications 1985;129(1):34-40.
1985: Dix T A; Fontana R; Panthani A; Marnett L J
Hematin-catalyzed epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by polyunsaturated fatty acid hydroperoxides.
The Journal of biological chemistry 1985;260(9):5358-65.
1985: Dix T A; Marnett L J
Conversion of linoleic acid hydroperoxide to hydroxy, keto, epoxyhydroxy, and trihydroxy fatty acids by hematin.
The Journal of biological chemistry 1985;260(9):5351-7.
1985: Marnett L J; Hurd H K; Hollstein M C; Levin D E; Esterbauer H; Ames B N
Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104.
Mutation research 1985;148(1-2):25-34.
1985: Honn K V; Weller P; Marnett L J
Effects of prostaglandins possessing an alpha,beta-unsaturated carbonyl on tumor growth and differentiation.
Advances in prostaglandin, thromboxane, and leukotriene research 1985;15():411-3.
1985: Marnett L J; Weller P E; Markey C M; Alward A; Dix T A
Transformations of unsaturated fatty acid hydroperoxides.
Advances in prostaglandin, thromboxane, and leukotriene research 1985;15():143-6.
1984: Bull A W; Nigro N D; Golembieski W A; Crissman J D; Marnett L J
In vivo stimulation of DNA synthesis and induction of ornithine decarboxylase in rat colon by fatty acid hydroperoxides, autoxidation products of unsaturated fatty acids.
Cancer research 1984;44(11):4924-8.
1984: Samokyszyn V M; Sloane B F; Honn K V; Marnett L J
Cooxidation of 13-cis-retinoic acid by prostaglandin H synthase.
Biochemical and biophysical research communications 1984;124(2):430-6.
1984: Basu A K; Marnett L J; Romano L J
Dissociation of malondialdehyde mutagenicity in Salmonella typhimurium from its ability to induce interstrand DNA cross-links.
Mutation research 1984;129(1):39-46.
1984: Marnett L J; Siedlik P H; Ochs R C; Pagels W R; Das M; Honn K V; Warnock R H; Tainer B E; Eling T E
Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom.
Molecular pharmacology 1984;26(2):328-35.
1984: Levin D E; Marnett L J; Ames B N
Spontaneous and mutagen-induced deletions: mechanistic studies in Salmonella tester strain TA102.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(14):4457-61.
1984: Basu A K; Marnett L J
Molecular requirements for the mutagenicity of malondialdehyde and related acroleins.
Cancer research 1984;44(7):2848-54.
1984: Dix T A; Marnett L J
Detection of the metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation.
Methods in enzymology 1984;105():347-52.
1984: Siedlik P H; Marnett L J
Oxidizing radical generation by prostaglandin H synthase.
Methods in enzymology 1984;105():412-6.
1983: Sevilla M D; Neta P; Marnett L J
Reaction of the antithrombotic and antimetastatic agent, nafazatrom, with oxidizing radicals.
Biochemical and biophysical research communications 1983;115(3):800-6.
1983: Dix T A; Marnett L J
Metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation.
Science (New York, N.Y.) 1983;221(4605):77-9.
1983: Fischer S M; Ogle S; Marnett L J; Nesnow S; Slaga T J
The lack of initiating and/or promoting activity of sodium malondialdehyde on SENCAR mouse skin.
Cancer letters 1983;19(1):61-6.
1983: Pagels W R; Sachs R J; Marnett L J; Dewitt D L; Day J S; Smith W L
Immunochemical evidence for the involvement of prostaglandin H synthase in hydroperoxide-dependent oxidations by ram seminal vesicle microsomes.
The Journal of biological chemistry 1983;258(10):6517-23.
1983: Panthananickal A; Weller P; Marnett L J
Stereoselectivity of the epoxidation of 7,8-dihydrobenzo[a]pyrene by prostaglandin H synthase and cytochrome P-450 determined by the identification of polyguanylic acid adducts.
The Journal of biological chemistry 1983;258(7):4411-8.
1983: Morton K C; King C M; Vaught J B; Wang C Y; Lee M S; Marnett L J
Prostaglandin H synthase-mediated reaction of carcinogenic arylamines with tRNA and homopolyribonucleotides.
Biochemical and biophysical research communications 1983;111(1):96-103.
1983: Bull A W; Marnett L J; Dawe E J; Nigro N D
Stimulation of deoxythymidine incorporation in the colon of rats treated intrarectally with bile acids and fats.
Carcinogenesis 1983;4(2):207-10.
1983: Basu A K; Marnett L J
Unequivocal demonstration that malondialdehyde is a mutagen.
Carcinogenesis 1983;4(3):331-3.
1983: Marnett L J; Dix T A; Sachs R J; Siedlik P H
Oxidations by fatty acid hydroperoxides and prostaglandin synthase.
Advances in prostaglandin, thromboxane, and leukotriene research 1983;11():79-86.
1982: Reed G A; Marnett L J
Metabolism and activation of 7,8-dihydrobenzo[a]pyrene during prostaglandin biosynthesis. Intermediacy of a bay-region epoxide.
The Journal of biological chemistry 1982;257(19):11368-76.
1982: Marnett L J; Siedlik P H; Fung L W
Oxidation of phenidone and BW755C by prostaglandin endoperoxide synthetase.
The Journal of biological chemistry 1982;257(12):6957-64.
1982: Capdevila J; Marnett L J; Chacos N; Prough R A; Estabrook R W
Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(3):767-70.
1982: Marnett L J; Panthananickal A; Reed G A
Metabolic activation of 7,8-dihydroxy-7,8-dihydrobenzo[a]-pyrene during prostaglandin biosynthesis.
Drug metabolism reviews 1982;13(2):235-47.
1981: Marnett L J
Polycyclic aromatic hydrocarbon oxidation during prostaglandin biosynthesis.
Life sciences 1981;29(6):531-46.
1981: Honn K V; Bockman R S; Marnett L J
Prostaglandins and cancer: a review of tumor initiation through tumor metastasis.
Prostaglandins 1981;21(5):833-64.
1981: Panthananickal A; Marnett L J
Arachidonic acid-dependent metabolism of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to polyguanylic acid-binding derivatives.
Chemico-biological interactions 1981;33(2-3):239-52.
1980: Marnett L J; Bienkowski M J
Hydroperoxide-dependent oxygenation of trans-7,8-dihydroxy-7,8-dihydro benzo[a]pyrene by ram seminal vesicle microsomes. Source of the oxygen.
Biochemical and biophysical research communications 1980;96(2):639-47.
1980: Marnett L J; Tuttle M A
Comparison of the mutagenicities of malondialdehyde and the side products formed during its chemical synthesis.
Cancer research 1980;40(2):276-82.
1980: Porter N A; Wolf R A; Pagels W R; Marnett L J
A test for the intermediacy of 11-hydroperoxyeicosa-5,8,12,14-tetraenoic acid [11-HPETE] in prostaglandin biosynthesis.
Biochemical and biophysical research communications 1980;92(2):349-55.
1980: Egan R W; Gale P H; Beveridge G C; Marnett L J; Kuehl F A
Direct and indirect involvement of radical scavengers during prostaglandin biosynthesis.
Advances in prostaglandin and thromboxane research 1980;6():153-5.
1980: Marnett L J; Bienkowski M J; Pagels W R; Reed G A
Mechanism of xenobiotic cooxygenation coupled to prostaglandin H2 biosynthesis.
Advances in prostaglandin and thromboxane research 1980;6():149-51.
1979: Marnett L J; Bienkowski M J; Raban M; Tuttle M A
Studies of the hydrolysis of 14C-labeled tetraethoxypropane to malondialdehyde.
Analytical biochemistry 1979;99(2):458-63.
1979: Marnett L J; Johnson J T; Bienkowski M J
Arachidonic acid-dependent metabolism of 7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene by ram seminal vesicles.
FEBS letters 1979;106(1):13-6.
1979: Marnett L J; Reed G A
Peroxidatic oxidation of benzo[a]pyrene and prostaglandin biosynthesis.
Biochemistry 1979;18(14):2923-9.
1979: Marnett L J; Bienkowski M J; Pagels W R
Oxygen 18 investigation of the prostaglandin synthetase-dependent co-oxidation of diphenylisobenzofuran.
The Journal of biological chemistry 1979;254(12):5077-82.
1979: Honn K V; Dunn J R; Morgan L R; Bienkowski M; Marnett L J
Inhibition of DNA synthesis in Harding-Passey melanoma cells by prostaglandins A1 and A2: comparison with chemotherapeutic agents.
Biochemical and biophysical research communications 1979;87(3):795-801.
1979: Iida H; Kimura J; Johnson J J; Marnett L J
Microsomal drug hydroxylase activity of Tetrahymena pyriformis.
Comparative biochemistry and physiology. C: Comparative pharmacology 1979;63C(2):381-7.
1978: Egan R W; Gale P H; Beveridge G C; Phillips G B; Marnett L J
Radical scavenging as the mechanism for stimulation of prostaglandin cyclooxygenase and depression of inflammation by lipoic acid and sodium iodide.
Prostaglandins 1978;16(6):861-9.
1978: Marnett L J; Reed G A; Dennison D J
Prostaglandin synthetase dependent activation of 7,8-dihydro-7,8-dihydroxy-geno (a) pyrene to mutagenic derivativies.
Biochemical and biophysical research communications 1978;82(1):210-6.
1977: Marnett L J; Reed G A; Johnson J T
Prostaglandin synthetase dependent benzo(a)pyrene oxidation: products of the oxication and inhibition of their formation by antioxidants.
Biochemical and biophysical research communications 1977;79(2):569-76.
1977: Marnett L J; Bienkowski M J
Nonenzymatic reduction of prostaglandin H by lipoic acid.
Biochemistry 1977;16(19):4303-7.
1977: Marnett L J; Wilcox C L
Stimulation of prostaglandin biosynthesis by lipoic acid.
Biochimica et biophysica acta 1977;487(1):222-30.
1975: Marnett L J; Wlodawer P; Samuelsson B
Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland.
The Journal of biological chemistry 1975;250(21):8510-7.
1974: Marnett L J; Wlodawer P; Samuelsson B
Light emission during the action of prostaglandin synthetase.
Biochemical and biophysical research communications 1974;60(4):1286-94.

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