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Victor Marquez
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51
Blumberg, Peter
34
Lewin, Nancy
31
Kelley, James
19
Barchi, Joseph
18
Lee, Jeewoo
17
Nicklaus, Marc
14
Johns, David
13
Kang, Ji-Hye
13
Ford, Harry
13
Agbaria, Riad
13
Sigano, Dina
12
Mitsuya, Hiroaki
12
Wang, Shulin
10
Jacobson, Kenneth
10
Nacro, Kassoum
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All Publications
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2009: Philosof-Mazor Liron; Volinsky Roman; Jopp Jurgen; Blumberg Peter; Rapaport Hanna; Marquez Victor E; Jelinek Raz
Lipid-modulated pharmacophore nanorods assembled at the air/water interface.
Chemphyschem : a European journal of chemical physics and physical chemistry 2009;10(15):2615-9.
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2009: Boyer Paul L; Vu B Christie; Ambrose Zandrea; Julias John G; Warnecke Svenja; Liao Chenzhong; Meier Chris; Marquez Victor E; Hughes Stephen H
The nucleoside analogue D-carba T blocks HIV-1 reverse transcription.
Journal of medicinal chemistry 2009;52(17):5356-64.
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2009: Saneyoshi Hisao; Mazzini Stefania; Aviñó Anna; Portella Guillem; González Carlos; Orozco Modesto; Marquez Víctor E; Eritja Ramon
Conformationally rigid nucleoside probes help understand the role of sugar pucker and nucleobase orientation in the thrombin-binding aptamer.
Nucleic acids research 2009;37(17):5589-601.
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2009: Russ Pamela L; Gonzalez-Moa Maria J; Vu B Christie; Sigano Dina M; Kelley James A; Lai Christopher C; Deschamps Jeffrey R; Hughes Stephen H; Marquez Victor E
North- and south-bicyclo[3.1.0]hexene nucleosides: the effect of ring planarity on anti-HIV activity.
ChemMedChem 2009;4(8):1354-63.
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2009: Comin Maria J; Czifra Gabriella; Kedei Noemi; Telek Andrea; Lewin Nancy E; Kolusheva Sofiya; Velasquez Julia F; Kobylarz Ryan; Jelinek Raz; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths.
Journal of medicinal chemistry 2009;52(10):3274-83.
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2009: Kang Ji-Hye; Garg Himanshu; Sigano Dina M; Francella Nicholas; Blumenthal Robert; Marquez Victor E
Ceramides: branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency.
Bioorganic & medicinal chemistry 2009;17(4):1498-505.
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2009: Saneyoshi Hisao; Mazzini Stefania; Aviñó Anna; Portella Guillem; González Carlos; Orozco Modesto; Marquez Victor E; Eritja Ramon
The use of conformationally rigid nucleoside probes to study the role of sugar pucker and nucleobase orientation in the thrombin binding aptamer.
Nucleic acids symposium series (2004) 2009;(53):109-10.
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2008: Saneyoshi Hisao; Michel Benoît Y; Choi Yongseok; Strazewski Peter; Marquez Victor E
Synthesis of conformationally locked versions of puromycin analogues.
The Journal of organic chemistry 2008;73(23):9435-8.
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2008: Philosof-Mazor Liron; Volinsky Roman; Comin Maria J; Lewin Nancy E; Kedei Noemi; Blumberg Peter M; Marquez Victor E; Jelinek Raz
Self-assembly and lipid interactions of diacylglycerol lactone derivatives studied at the air/water interface.
Langmuir : the ACS journal of surfaces and colloids 2008;24(19):11043-52.
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2008: Duan Dehui; Sigano Dina M; Kelley James A; Lai Christopher C; Lewin Nancy E; Kedei Noemi; Peach Megan L; Lee Jeewoo; Abeyweera Thushara P; Rotenberg Susan A; Kim Hee; Kim Young Ho; El Kazzouli Saïd; Chung Jae-Uk; Young Howard A; Young Matthew R; Baker Alyson; Colburn Nancy H; Haimovitz-Friedman Adriana; Truman Jean-Philip; Parrish Damon A; Deschamps Jeffrey R; Perry Nicholas A; Surawski Robert J; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.
Journal of medicinal chemistry 2008;51(17):5198-220.
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2008: Blumberg P M; Kedei N; Lewin N E; Yang D; Czifra G; Pu Y; Peach M L; Marquez V E
Wealth of opportunity - the C1 domain as a target for drug development.
Current drug targets 2008;9(8):641-52.
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2008: Barchi Joseph J; Karki Rajeshri G; Nicklaus Marc C; Siddiqui Maqbool A; George Clifford; Mikhailopulo Igor A; Marquez Victor E
Comprehensive structural studies of 2',3'-difluorinated nucleosides: comparison of theory, solution, and solid state.
Journal of the American Chemical Society 2008;130(28):9048-57.
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2008: Comin Maria J; Vu B Christie; Boyer Paul L; Liao Chenzhong; Hughes Stephen H; Marquez Victor E
D-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase.
ChemMedChem 2008;3(7):1129-34.
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2008: Choi Sung Hee; Czifra Gabriella; Kedei Noemi; Lewin Nancy E; Lazar Jozsef; Pu Yongmei; Marquez Victor E; Blumberg Peter M
Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta.
The Journal of biological chemistry 2008;283(16):10543-9.
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2008: Ludek Olaf R; Schroeder Gottfried K; Wolfenden Richard; Marquez Victor E
Synthesis of conformationally locked carbocyclic 1,3-diazepinone nucleosides as inhibitors of cytidine deaminase.
Nucleic acids symposium series (2004) 2008;(52):659-60.
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2008: Saneyoshi Hisao; Vu B Christie; Hughes Stephen H; Boyer Paul L; Sarafianos Stefan G; Marquez Victor E
Synthesis of conformationally locked carbocyclic nucleoside phosphonates to probe the active site of HIV-1 RT.
Nucleic acids symposium series (2004) 2008;(52):623-4.
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2008: Marquez Victor E; Sun Guangyu; Siddiqui Maqbool A; Lee Yi-Chien; Barchi Joseph J; Filippov Igor V; Landsman Nicklaus A; Kelley James A
What are the consequences of freezing the anomeric effect in nucleosides?
Nucleic acids symposium series (2004) 2008;(52):543-4.
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2007: Boyer Paul L; Julias John G; Ambrose Zandrea; Siddiqui Maqbool A; Marquez Victor E; Hughes Stephen H
The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants.
Journal of molecular biology 2007;371(4):873-82.
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2007: Choi Yongseok; Pu Yongmei; Peach Megan L; Kang Ji-Hye; Lewin Nancy E; Sigano Dina M; Garfield Susan H; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.
Journal of medicinal chemistry 2007;50(15):3465-81.
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2007: Comin Maria J; Agbaria Riad; Ben-Kasus Tsipi; Huleihel Mahmoud; Liao Chenzhong; Sun Guangyu; Nicklaus Marc C; Deschamps Jeffrey R; Parrish Damon A; Marquez Victor E
Sculpting the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve recognition by herpes thymidine kinase.
Journal of the American Chemical Society 2007;129(19):6216-22.
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2007: Malolanarasimhan Krishnan; Kedei Noemi; Sigano Dina M; Kelley James A; Lai Christopher C; Lewin Nancy E; Surawski Robert J; Pavlyukovets Vladimir A; Garfield Susan H; Wincovitch Stephen; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups.
Journal of medicinal chemistry 2007;50(5):962-78.
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2007: Siddiqui Maqbool A; Marquez Victor E
The triphosphate of beta-D-4'-C-ethynyl-2',3'-dideoxycytidine is the preferred enantiomer substrate for HIV reverse transcriptase.
Bioorganic & medicinal chemistry 2007;15(1):283-7.
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2007: Marquez Victor E; Comin Maria J
Rearranging the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve binding recognition by kinases.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):585-8.
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2007: Maderia Melissa; Shenoy Shilpa; Van Que N; Marquez Victor E; Barchi Joseph J
Biophysical studies of DNA modified with conformationally constrained nucleotides: comparison of 2'-exo (north) and 3'-exo (south) 'locked' templates.
Nucleic acids research 2007;35(6):1978-91.
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2006: Pu Yongmei; Peach Megan L; Garfield Susan H; Wincovitch Stephen; Marquez Victor E; Blumberg Peter M
Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms.
The Journal of biological chemistry 2006;281(44):33773-88.
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2006: Johnson Allison A; Sayer Jane M; Yagi Haruhiko; Patil Sachindra S; Debart Françoise; Maier Martin A; Corey David R; Vasseur Jean-Jacques; Burke Terrence R; Marquez Victor E; Jerina Donald M; Pommier Yves
Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.
The Journal of biological chemistry 2006;281(43):32428-38.
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2006: Marquez Victor E; Hughes Stephen H; Sei Shizuko; Agbaria Riad
The history of N-methanocarbathymidine: the investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent.
Antiviral research 2006;71(2-3):268-75.
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2006: Kang Ji-Hye; Benzaria Samira; Sigano Dina M; Lewin Nancy E; Pu Yongmei; Peach Megan L; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions.
Journal of medicinal chemistry 2006;49(11):3185-203.
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2006: Lee Jeewoo; Kang Ji-Hye; Han Kee-Chung; Kim Yerim; Kim Su Yeon; Youn Hae-Suk; Mook-Jung Inhee; Kim Hee; Lo Han Jee Hye; Ha Hee Jin; Kim Young Ho; Marquez Victor E; Lewin Nancy E; Pearce Larry V; Lundberg Daniel J; Blumberg Peter M
Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators.
Journal of medicinal chemistry 2006;49(6):2028-36.
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2006: Comin Maria J; Parrish Damon A; Deschamps Jeffrey R; Marquez Victor E
Synthesis of bicyclo[3.1.0]hexanes functionalized at the tip of the cyclopropane ring. Application to the synthesis of carbocyclic nucleosides.
Organic letters 2006;8(4):705-8.
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2005: Costanzi Stefano; Joshi Bhalchandra V; Maddileti Savitri; Mamedova Liaman; Gonzalez-Moa Maria J; Marquez Victor E; Harden T Kendall; Jacobson Kenneth A
Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.
Journal of medicinal chemistry 2005;48(26):8108-11.
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2005: Zhu Weimin; Burnette Angela; Dorjsuren Dorjbal; Roberts Paula E; Huleihel Mahmoud; Shoemaker Robert H; Marquez Victor E; Agbaria Riad; Sei Shizuko
Potent antiviral activity of north-methanocarbathymidine against Kaposi's sarcoma-associated herpesvirus.
Antimicrobial agents and chemotherapy 2005;49(12):4965-73.
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2005: Marquez Victor E; Kelley James A; Agbaria Riad; Ben-Kasus Tisipi; Cheng Jonathan C; Yoo Christine B; Jones Peter A
Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy.
Annals of the New York Academy of Sciences 2005;1058():246-54.
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2005: Marquez Victor E; Choi Yongseok; Comin Maria Julieta; Russ Pamela; George Clifford; Huleihel Mahmoud; Ben-Kasus Tsipi; Agbaria Riad
Understanding how the herpes thymidine kinase orchestrates optimal sugar and nucleobase conformations to accommodate its substrate at the active site: a chemical approach.
Journal of the American Chemical Society 2005;127(43):15145-50.
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2005: Kang Ji-Hye; Peach Megan L; Pu Yongmei; Lewin Nancy E; Nicklaus Marc C; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.
Journal of medicinal chemistry 2005;48(18):5738-48.
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2005: Pu Yongmei; Perry Nicholas A; Yang Dazhi; Lewin Nancy E; Kedei Noemi; Braun Derek C; Choi Sung Hee; Blumberg Peter M; Garfield Susan H; Stone James C; Duan Dehui; Marquez Victor E
A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.
The Journal of biological chemistry 2005;280(29):27329-38.
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2005: Ben-Kasus Tsipi; Ben-Zvi Zvi; Marquez Victor E; Kelley James A; Agbaria Riad
Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells.
Biochemical pharmacology 2005;70(1):121-33.
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2005: Hodge David R; Peng Benjamin; Pompeia Celine; Thomas Suneetha; Cho Edward; Clausen Peter A; Marquez Victor E; Farrar William L
Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation.
Cancer biology & therapy 2005;4(5):585-92.
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2005: Huleihel Mahmoud; Talishanisky Marina; Ford Harry; Marquez Victor E; Kelley James A; Johns David G; Agbaria Riad
Dynamics of the antiviral activity of N-methanocarbathymidine against herpes simplex virus type 1 in cell culture.
International journal of antimicrobial agents 2005;25(5):427-32.
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2005: Malolanarasimhan Krishnan; Lai Christopher C; Kelley James A; Iaccarino Lynn; Reynolds Della; Young Howard A; Marquez Victor E
Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe.
Bioorganic & medicinal chemistry 2005;13(8):2717-22.
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2005: Joshi Bhalchandra V; Moon Hyung Ryong; Fettinger James C; Marquez Victor E; Jacobson Kenneth A
A new synthetic route to (North)-methanocarba nucleosides designed as A3 adenosine receptor agonists.
The Journal of organic chemistry 2005;70(2):439-47.
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2005: Wu Zhengrong; Maderia Melissa; Barchi Joseph J; Marquez Victor E; Bax Ad
Changes in DNA bending induced by restricting nucleotide ring pucker studied by weak alignment NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):24-8.
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2005: Boyer Paul L; Julias John G; Marquez Victor E; Hughes Stephen H
Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases.
Journal of molecular biology 2005;345(3):441-50.
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2005: Sun Guangyu; Voigt Johannes H; Marquez Victor E; Nicklaus Marc C
Prosit, an online service to calculate pseudorotational parameters of nucleosides and nucleotides.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):1029-32.
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2005: Maderia Melissa; Wu Justin; Bax Ad; Shenoy Shilpa; O'Keefe Barry; Marquez Victor E; Barchi Joseph J
Engineering DNA topology with locked nucleosides: a structural study.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):687-90.
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2005: Marquez Victor E; Barchi Joseph J; Kelley James A; Rao Kambhampati V R; Agbaria Riad; Ben-Kasus Tsipi; Cheng Jonathan C; Yoo Christine B; Jones Peter A
Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):305-18.
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2004: Siddiqui Maqbool A; Hughes Stephen H; Boyer Paul L; Mitsuya Hiroaki; Van Que N; George Clifford; Sarafinanos Stefan G; Marquez Victor E
A 4'-C-ethynyl-2',3'-dideoxynucleoside analogue highlights the role of the 3'-OH in anti-HIV active 4'-C-ethynyl-2'-deoxy nucleosides.
Journal of medicinal chemistry 2004;47(21):5041-8.
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2004: Sun Guangyu; Voigt Johannes H; Filippov Igor V; Marquez Victor E; Nicklaus Marc C
PROSIT: pseudo-rotational online service and interactive tool, applied to a conformational survey of nucleosides and nucleotides.
Journal of chemical information and computer sciences 2004;44(5):1752-62.
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2004: Tamamura Hirokazu; Sigano Dina M; Lewin Nancy E; Peach Megan L; Nicklaus Marc C; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C).
Journal of medicinal chemistry 2004;47(20):4858-64.
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2004: Kang Ji-Hye; Kim Su Yeon; Lee Jeewoo; Marquez Victor E; Lewin Nancy E; Pearce Larry V; Blumberg Peter M
Macrocyclic diacylglycerol-bis-lactones as conformationally constrained analogues of diacylglycerol-lactones. Interactions with protein kinase C.
Journal of medicinal chemistry 2004;47(16):4000-7.
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2004: Kang Ji-Hye; Siddiqui Maqbool A; Sigano Dina M; Krajewski Krzysztof; Lewin Nancy E; Pu Yongmei; Blumberg Peter M; Lee Jeewoo; Marquez Victor E
Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones.
Organic letters 2004;6(14):2413-6.
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2004: Schelling Pierre; Claus Michael T; Johner Regula; Marquez Victor E; Schulz Georg E; Scapozza Leonardo
Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells.
The Journal of biological chemistry 2004;279(31):32832-8.
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2004: Duan Dehui; Lewin Nancy E; Sigano Dina M; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands.
Journal of medicinal chemistry 2004;47(12):3248-54.
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2004: Pompeia Celine; Hodge David R; Plass Christoph; Wu Yue-Zhong; Marquez Victor E; Kelley James A; Farrar William L
Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell line.
Cancer research 2004;64(10):3465-73.
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2004: Lee Jeewoo; Kim Su Yeon; Kang Ji-Hye; Acs Geza; Acs Peter; Blumberg Peter M; Marquez Victor E
Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands.
European journal of medicinal chemistry 2004;39(1):69-77.
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2004: Tamamura Hirokazu; Sigano Dina M; Lewin Nancy E; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones.
Journal of medicinal chemistry 2004;47(3):644-55.
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2004: Marquez Victor E; Ben-Kasus Tsipi; Barchi Joseph J; Green Karen M; Nicklaus Marc C; Agbaria Riad
Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker.
Journal of the American Chemical Society 2004;126(2):543-9.
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2004: Marquez Victor E
Chemical and biological consequences of locking the conformation of nucleosides at the two antipodal extremes of the pseudorotational cycle.
Nucleic acids symposium series (2004) 2004;(48):11-2.
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2004: Horton John R; Ratner Gary; Banavali Nilesh K; Huang Niu; Choi Yongseok; Maier Martin A; Marquez Victor E; MacKerell Alexander D; Cheng Xiaodong
Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase.
Nucleic acids research 2004;32(13):3877-86.
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2003: Marquez Victor E; Eritja Ramon; Kelley James A; Vanbemmel Dana; Christman Judith K
Potent inhibition of HhaI DNA methylase by the aglycon of 2-(1H)-pyrimidinone riboside (zebularine) at the GCGC recognition domain.
Annals of the New York Academy of Sciences 2003;1002():154-64.
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2003: Choi Yongseok; Sun Guangyu; George Clifford; Nicklaus Marc C; Kelley James A; Marquez Victor E
Synthesis and conformational analysis of a locked analogue of carbovir built on a bicyclo[3.1.0]hex-2-enyl template.
Nucleosides, nucleotides & nucleic acids 2003;22(12):2077-91.
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2003: Wang Qiming J; Fang Tzan-Wei; Yang Dazhi; Lewin Nancy E; Van Lint Johan; Marquez Victor E; Blumberg Peter M
Ligand structure-activity requirements and phospholipid dependence for the binding of phorbol esters to protein kinase D.
Molecular pharmacology 2003;64(6):1342-8.
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2003: Russ Pamela; Schelling Pierre; Scapozza Leonardo; Folkers Gerd; Clercq Erik De; Marquez Victor E
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
Journal of medicinal chemistry 2003;46(23):5045-54.
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2003: Kim Hak Sung; Ohno Michihiro; Xu Bin; Kim Hea Ok; Choi Yongseok; Ji Xiao D; Maddileti Savitri; Marquez Victor E; Harden T Kendall; Jacobson Kenneth A
2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.
Journal of medicinal chemistry 2003;46(23):4974-87.
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2003: Hamer Dean H; Bocklandt Sven; McHugh Louise; Chun Tae-Wook; Blumberg Peter M; Sigano Dina M; Marquez Victor E
Rational design of drugs that induce human immunodeficiency virus replication.
Journal of virology 2003;77(19):10227-36.
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2003: Choi Yongseok; George Clifford; Comin Maria J; Barchi Joseph J; Kim Hak Sung; Jacobson Kenneth A; Balzarini Jan; Mitsuya Hiroaki; Boyer Paul L; Hughes Stephen H; Marquez Victor E
A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.
Journal of medicinal chemistry 2003;46(15):3292-9.
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2003: Marquez Victor E; Blumberg Peter M
Synthetic diacylglycerols (DAG) and DAG-lactones as activators of protein kinase C (PK-C).
Accounts of chemical research 2003;36(6):434-43.
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2003: Choi Yongseok; Kang Ji-Hye; Lewin Nancy E; Blumberg Peter M; Lee Jeewoo; Marquez Victor E
Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain.
Journal of medicinal chemistry 2003;46(13):2790-3.
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2003: Kang Ji-Hye; Chung Hye-Eun; Kim Su Yeon; Kim Yerim; Lee Jeewoo; Lewin Nancy E; Pearce Larry V; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones.
Bioorganic & medicinal chemistry 2003;11(12):2529-39.
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2003: Choi Yongseok; Moon Hyung R; Yoshimura Yuichi; Marquez Victor E
Recent advances in the synthesis of conformationally locked nucleosides and their success in probing the critical question of conformational preferences by their biological targets.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):547-57.
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2003: Sigano Dina M; Peach Megan L; Nacro Kassoum; Choi Yongseok; Lewin Nancy E; Nicklaus Marc C; Blumberg Peter M; Marquez Victor E
Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).
Journal of medicinal chemistry 2003;46(9):1571-9.
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2002: Noy Roy; Ben-Zvi Zvi; Elezra Miri; Candotti Fabio; Ford Jr Harry; Morris John C; Marquez Victor E; Johns David G; Agbaria Riad
Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene.
Cancer chemotherapy and pharmacology 2002;50(5):360-6.
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2002: Yoshimura Yuichi; Moon Hyung R; Choi Yongseok; Marquez Victor E
Enantioselective synthesis of bicyclo[3.1.0]hexane carbocyclic nucleosides via a lipase-catalyzed asymmetric acetylation. Characterization of an unusual acetal byproduct.
The Journal of organic chemistry 2002;67(17):5938-45.
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2002: Hernandez Susana; Ford Harry; Marquez Victor E
Is the anomeric effect an important factor in the rate of adenosine deaminase catalyzed hydrolysis of purine nucleosides? A direct comparison of nucleoside analogues constructed on ribose and carbocyclic templates with equivalent heterocyclic bases selected to promote hydration.
Bioorganic & medicinal chemistry 2002;10(8):2723-30.
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2002: Zalah Livnat; Huleihel Mahmoud; Manor Esther; Konson Alexander; Ford Harry; Marquez Victor E; Johns David G; Agbaria Riad
Metabolic pathways of N-methanocarbathymidine, a novel antiviral agent, in native and herpes simplex virus type 1 infected Vero cells.
Antiviral research 2002;55(1):63-75.
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2002: Noy Roy; Ben-Zvi Zvi; Manor Esther; Candotti Fabio; Morris John C; Ford Harry; Marquez Victor E; Johns David G; Agbaria Riad
Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase.
Molecular cancer therapeutics 2002;1(8):585-93.
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2002: Choi Yongseok; George Clifford; Strazewski Peter; Marquez Victor E
Synthesis of a conformationally locked version of puromycin amino nucleoside.
Organic letters 2002;4(4):589-92.
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2002: Kim Hak Sung; Ravi R Gnana; Marquez Victor E; Maddileti Savitri; Wihlborg Anna-Karin; Erlinge David; Malmsjö Malin; Boyer José L; Harden T Kendall; Jacobson Kenneth A
Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.
Journal of medicinal chemistry 2002;45(1):208-18.
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2002: Garcia-Bermejo Maria Laura; Leskow Federico Coluccio; Fujii Teruhiko; Wang Qiming; Blumberg Peter M; Ohba Motoi; Kuroki Toshio; Han Kee-Chung; Lee Jeewoo; Marquez Victor E; Kazanietz Marcelo G
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha.
The Journal of biological chemistry 2002;277(1):645-55.
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2001: Lee J; Han K C; Kang J H; Pearce L L; Lewin N E; Yan S; Benzaria S; Nicklaus M C; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.
Journal of medicinal chemistry 2001;44(25):4309-12.
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2001: Ravi G; Lee K; Ji X; Kim H S; Soltysiak K A; Marquez V E; Jacobson K A
Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings.
Bioorganic & medicinal chemistry letters 2001;11(17):2295-300.
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2001: Nacro K; Sigano D M; Yan S; Nicklaus M C; Pearce L L; Lewin N E; Garfield S H; Blumberg P M; Marquez V E
An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P).
Journal of medicinal chemistry 2001;44(12):1892-904.
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2001: Wang Q J; Fang T W; Nacro K; Marquez V E; Wang S; Blumberg P M
Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions.
The Journal of biological chemistry 2001;276(22):19580-7.
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2001: Lee K; Ravi G; Ji X D; Marquez V E; Jacobson K A
Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications.
Bioorganic & medicinal chemistry letters 2001;11(10):1333-7.
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2001: Marquez V E; Wang P; Nicklaus M C; Maier M; Manoharan M; Christman J K; Banavali N K; Mackerell A D
Inhibition of (cytosine C5)-methyltransferase by oligonucleotides containing flexible (cyclopentane) and conformationally constrained (bicyclo[3.1.0]hexane) abasic sites.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):451-9.
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2001: Jacobson K A; Ravi R G; Nandanan E; Kim H S; Moro S; Kim Y C; Lee K; Barak D; Marquez V E; Ji X D
Ribose modified nucleosides and nucleotides as ligands for purine receptors.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):333-41.
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2001: Lee J; Han K C; Lee S Y; Kim S Y; Kang J H; Lewin N E; Best L S; Blumberg P M; Marquez V E
5-acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel template for protein kinase C (PKC) binding.
Farmaco (Società chimica italiana : 1989) 2001;56(3):203-10.
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2001: Lee J; Lee J; Kim J; Kim S Y; Chun M W; Cho H; Hwang S W; Oh U; Park Y H; Marquez V E; Beheshti M; Szabo T; Blumberg P M
N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics.
Bioorganic & medicinal chemistry 2001;9(1):19-32.
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2000: Moon H R; Ford H; Marquez V E
A remarkably simple chemicoenzymatic approach to structurally complex bicyclo[3.1.0]hexane carbocyclic nucleosides.
Organic letters 2000;2(24):3793-6.
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2000: Mu L; Sarafianos S G; Nicklaus M C; Russ P; Siddiqui M A; Ford H; Mitsuya H; Le R; Kodama E; Meier C; Knispel T; Anderson L; Barchi J J; Marquez V E
Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase.
Biochemistry 2000;39(37):11205-15.
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2000: Tamamura H; Bienfait B; Nacro K; Lewin N E; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C.
Journal of medicinal chemistry 2000;43(17):3209-17.
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2000: Prota A; Vogt J; Pilger B; Perozzo R; Wurth C; Marquez V E; Russ P; Schulz G E; Folkers G; Scapozza L
Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine.
Biochemistry 2000;39(31):9597-603.
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2000: Jacobson K A; Ji X; Li A H; Melman N; Siddiqui M A; Shin K J; Marquez V E; Ravi R G
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.
Journal of medicinal chemistry 2000;43(11):2196-203.
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2000: Shin K J; Moon H R; George C; Marquez V E
Construction of the bicyclo[3.1.0]hexane template of a conformationally locked carbocyclic adenosine via an olefin keto-carbene cycloaddition.
The Journal of organic chemistry 2000;65(7):2172-8.
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2000: Wang Q J; Fang T W; Fenick D; Garfield S; Bienfait B; Marquez V E; Blumberg P M
The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein.
The Journal of biological chemistry 2000;275(16):12136-46.
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2000: Nacro K; Bienfait B; Lewin N E; Blumberg P M; Marquez V E
Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones.
Bioorganic & medicinal chemistry letters 2000;10(7):653-5.
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2000: Nacro K; Bienfait B; Lee J; Han K C; Kang J H; Benzaria S; Lewin N E; Bhattacharyya D K; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
Journal of medicinal chemistry 2000;43(5):921-44.
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2000: Nandanan E; Jang S Y; Moro S; Kim H O; Siddiqui M A; Russ P; Marquez V E; Busson R; Herdewijn P; Harden T K; Boyer J L; Jacobson K A
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands.
Journal of medicinal chemistry 2000;43(5):829-42.
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2000: Ford H; Dai F; Mu L; Siddiqui M A; Nicklaus M C; Anderson L; Marquez V E; Barchi J J
Adenosine deaminase prefers a distinct sugar ring conformation for binding and catalysis: kinetic and structural studies.
Biochemistry 2000;39(10):2581-92.
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2000: Siddiqui M A; Driscoll J S; Abushanab E; Kelley J A; Barchi J J; Marquez V E
The "beta-fluorine effect" in the non-metal hydride radical deoxygenation of fluorine-containing nucleoside xanthates.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):1-12.
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1999: Wang Q J; Bhattacharyya D; Garfield S; Nacro K; Marquez V E; Blumberg P M
Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein.
The Journal of biological chemistry 1999;274(52):37233-9.
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1999: Ikeda H; Abushanab E; Marquez V E
The assembly of beta-methylene-TAD, a metabolically stable analogue of the antitumor agent TAD, by the stepwise esterification of monodeprotected methylenebis-(phosphonate) benzyl esters under Mitsunobu conditions.
Bioorganic & medicinal chemistry letters 1999;9(21):3069-74.
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1999: Lee J; Park S U; Kim J Y; Kim J K; Lee J; Oh U; Marquez V E; Beheshti M; Wang Q J; Modarres S; Blumberg P M
3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists.
Bioorganic & medicinal chemistry letters 1999;9(20):2909-14.
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1999: Caloca M J; Garcia-Bermejo M L; Blumberg P M; Lewin N E; Kremmer E; Mischak H; Wang S; Nacro K; Bienfait B; Marquez V E; Kazanietz M G
beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11854-9.
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1999: Lee J; Kang J H; Lee S Y; Han K C; Torres C M; Bhattacharyya D K; Blumberg P M; Marquez V E
Protein kinase C ligands based on tetrahydrofuran templates containing a new set of phorbol ester pharmacophores.
Journal of medicinal chemistry 1999;42(20):4129-39.
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1999: Marquez V E; Nacro K; Benzaria S; Lee J; Sharma R; Teng K; Milne G W; Bienfait B; Wang S; Lewin N E; Blumberg P M
The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands.
Pharmacology & therapeutics 1999;82(2-3):251-61.
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1999: Marquez V E; Russ P; Alonso R; Siddiqui M A; Shin K J; George C; Nicklaus M C; Dai F; Ford H
Conformationally restricted nucleosides. The reaction of adenosine deaminase with substrates built on a bicyclo[3.1.0]hexane template.
Nucleosides & nucleotides 1999;18(4-5):521-30.
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1998: Benzaria S; Bienfait B; Nacro K; Wang S; Lewin N E; Beheshti M; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C).
Bioorganic & medicinal chemistry letters 1998;8(23):3403-8.
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1998: Marquez V E; Sharma R; Wang S; Lewin N E; Blumberg P M; Kim I S; Lee J
Conformationally constrained analogues of diacylglycerol (DAG). 14. Dissection of the roles of the sn-1 and sn-2 carbonyls in DAG mimetics by isopharmacophore replacement.
Bioorganic & medicinal chemistry letters 1998;8(13):1757-62.
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1998: Jeong L S; Buenger G; McCormack J J; Cooney D A; Hao Z; Marquez V E
Carbocyclic analogues of the potent cytidine deaminase inhibitor 1-(beta-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one (zebularine).
Journal of medicinal chemistry 1998;41(14):2572-8.
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1998: Ikeda H; Fernandez R; Wilk A; Barchi J J; Huang X; Marquez V E
The effect of two antipodal fluorine-induced sugar puckers on the conformation and stability of the Dickerson-Drew dodecamer duplex [d(CGCGAATTCGCG)]2.
Nucleic acids research 1998;26(9):2237-44.
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1997: Barchi J J; Jeong L S; Siddiqui M A; Marquez V E
Conformational analysis of the complete series of 2' and 3' monofluorinated dideoxyuridines.
Journal of biochemical and biophysical methods 1997;34(1):11-29.
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1996: Lee J; Lewin N E; Acs P; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol. 13. Protein kinase C ligands based on templates derived from 2,3-dideoxy-L-erythro(threo)-hexono-1,4-lactone and 2-deoxyapiolactone.
Journal of medicinal chemistry 1996;39(25):4912-9.
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1996: Marquez V E; Siddiqui M A; Ezzitouni A; Russ P; Wang J; Wagner R W; Matteucci M D
Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides?
Journal of medicinal chemistry 1996;39(19):3739-47.
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1996: Lee J; Lewin N E; Blumberg P M; Marquez V E
Synthesis of bis-gamma-butyrolactones containing conformationally constrained (S)- and (R)-diacylglycerol structures.
Bioorganic & medicinal chemistry 1996;4(8):1299-305.
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1996: Wang S; Kazanietz M G; Blumberg P M; Marquez V E; Milne G W
Molecular modeling and site-directed mutagenesis studies of a phorbol ester-binding site in protein kinase C.
Journal of medicinal chemistry 1996;39(13):2541-53.
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1996: Driscoll J S; Siddiqui M A; Ford H; Kelley J A; Roth J S; Mitsuya H; Tanaka M; Marquez V E
Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 3. 6-Amino prodrugs of 2'-beta-fluoro-2',3'-dideoxyinosine.
Journal of medicinal chemistry 1996;39(8):1619-25.
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1996: Lee J; Sharma R; Wang S; Milne G W; Lewin N E; Szallasi Z; Blumberg P M; George C; Marquez V E
Conformationally constrained analogues of diacylglycerol. 12. Ultrapotent protein kinase C ligands based on a chiral 4,4-disubstituted heptono-1,4-lactone template.
Journal of medicinal chemistry 1996;39(1):36-45.
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1996: Lee J; Wang S; Milne G W; Sharma R; Lewin N E; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol. 11. Ultrapotent protein kinase C ligands based on a chiral 5-disubstituted tetrahydro-2-furanone template.
Journal of medicinal chemistry 1996;39(1):29-35.
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1996: Sharma R; Lee J; Wang S; Milne G W; Lewin N E; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol. 10. Ultrapotent protein kinase C ligands based on a racemic 5-disubstituted tetrahydro-2-furanone template.
Journal of medicinal chemistry 1996;39(1):19-28.
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1995: Acs G; Lee J; Marquez V E; Wang S; Milne G W; Du L; Lewin N E; Blumberg P M
Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids.
Journal of neurochemistry 1995;65(1):301-18.
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1995: Ford H; Siddiqui M A; Driscoll J S; Marquez V E; Kelley J A; Mitsuya H; Shirasaka T
Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 2. 6-Halo and 6-alkoxy prodrugs of 2'-beta-fluoro-2',3'-dideoxyinosine.
Journal of medicinal chemistry 1995;38(7):1189-95.
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1995: Cysyk R L; Malinowski N; Marquez V; Zaharevitz D; August E M; Moyer J D
Cyclopentenyl uracil: an effective inhibitor of uridine salvage in vivo.
Biochemical pharmacology 1995;49(2):203-7.
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1995: Barchi J J; Cooney D A; Hao Z; Weinberg Z H; Taft C; Marquez V E; Ford H
Improved synthesis of zebularine [1-(beta-D-ribofuranosyl)-dihydropyrimidin-2-one] nucleotides as inhibitors of human deoxycytidylate deaminase.
Journal of enzyme inhibition 1995;9(2):147-62.
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1994: Wang S; Zaharevitz D W; Sharma R; Marquez V E; Lewin N E; Du L; Blumberg P M; Milne G W
The discovery of novel, structurally diverse protein kinase C agonists through computer 3D-database pharmacophore search. Molecular modeling studies.
Journal of medicinal chemistry 1994;37(26):4479-89.
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1994: Jeong L S; Lim B B; Marquez V E
Synthesis of a 2,3-dideoxy-2,3-difluorofuranose with the D-lyxo configuration. An intramolecular rearrangement of methyl 5-O-benzoyl-2,3-dideoxy-2,3-difluoro-D-lyxofuranoside observed during the attempted synthesis of 1-(2,3-dideoxy-2,3-difluoro-beta-D-lyxofuranosyl)thymine.
Carbohydrate research 1994;262(1):103-14.
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1994: Rodriguez J B; Marquez V E; Nicklaus M C; Mitsuya H; Barchi J J
Conformationally locked nucleoside analogues. Synthesis of dideoxycarbocyclic nucleoside analogues structurally related to neplanocin C.
Journal of medicinal chemistry 1994;37(20):3389-99.
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1994: Wang S; Milne G W; Nicklaus M C; Marquez V E; Lee J; Blumberg P M
Protein kinase C. Modeling of the binding site and prediction of binding constants.
Journal of medicinal chemistry 1994;37(9):1326-38.
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1994: Gharehbaghi K; Paull K D; Kelley J A; Barchi J J; Marquez V E; Cooney D A; Monks A; Scudiero D; Krohn K; Jayaram H N
Cytotoxicity and characterization of an active metabolite of benzamide riboside, a novel inhibitor of IMP dehydrogenase.
International journal of cancer. Journal international du cancer 1994;56(6):892-9.
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1994: Li H; Hallows W H; Punzi J S; Marquez V E; Carrell H L; Pankiewicz K W; Watanabe K A; Goldstein B M
Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Biochemistry 1994;33(1):23-32.
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1994: Driscoll J S; Marquez V E
The design and synthesis of a new anticancer drug based on a natural product lead compound: from neplanocin A to cyclopentenyl cytosine (CPE-C).
Stem cells (Dayton, Ohio) 1994;12(1):7-12.
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1993: Agbaria R; Ford H; Kelley J A; Xie F; Politi P; Grem J L; Cooney D A; Marquez V E; Allegra C J; Johns D G
Measurement of cyclopentenyl cytosine 5'-triphosphate in vitro and in vivo by multidimensional high-performance liquid chromatography.
Analytical biochemistry 1993;213(1):90-6.
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1993: Lee J; Marquez V E; Blumberg P M; Krausz K W; Kazanietz M G
Conformationally constrained analogues of diacylglycerol (DAG)--II. Differential interaction of delta-lactones and gamma-lactones with protein kinase C (PK-C).
Bioorganic & medicinal chemistry 1993;1(2):119-23.
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1993: Burke T R; Lim B; Marquez V E; Li Z H; Bolen J B; Stefanova I; Horak I D
Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck.
Journal of medicinal chemistry 1993;36(4):425-32.
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1992: Siddiqui M A; Driscoll J S; Marquez V E; Roth J S; Shirasaka T; Mitsuya H; Barchi J J; Kelley J A
Chemistry and anti-HIV properties of 2'-fluoro-2',3'-dideoxyarabinofuranosylpyrimidines.
Journal of medicinal chemistry 1992;35(12):2195-201.
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1991: Driscoll J S; Marquez V E; Plowman J; Liu P S; Kelley J A; Barchi J J
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.
Journal of medicinal chemistry 1991;34(11):3280-4.
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1991: Zhen W; Jayaram H N; Marquez V E; Goldstein B M; Cooney D A; Weber G
Cytotoxicity of tiazofurin and its arabinose and xylose analogues in K562 cells.
Biochemical and biophysical research communications 1991;180(2):933-8.
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1991: Goldstein B M; Leary J F; Farley B A; Marquez V E; Levy P C; Rowley P T
Induction of HL60 cell differentiation by tiazofurin and its analogues: characterization and efficacy.
Blood 1991;78(3):593-8.
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1991: Barchi J J; Marquez V E; Driscoll J S; Ford H; Mitsuya H; Shirasaka T; Aoki S; Kelley J A
Potential anti-AIDS drugs. Lipophilic, adenosine deaminase-activated prodrugs.
Journal of medicinal chemistry 1991;34(5):1647-55.
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1991: Burke T R; Li Z H; Bolen J B; Marquez V E
Phosphonate-containing inhibitors of tyrosine-specific protein kinases.
Journal of medicinal chemistry 1991;34(5):1577-81.
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1991: Burke T R; Li Z H; Bolen J B; Chapekar M; Gang Y; Glazer R I; Rice K C; Marquez V E
Examination of the possible mediation of antineoplastic effects of opiates through the inhibition of tyrosine-specific protein kinases.
Biochemical pharmacology 1991;41(10):R17-20.
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1991: Tseng C K; Marquez V E; Milne G W; Wysocki R J; Mitsuya H; Shirasaki T; Driscoll J S
A ring-enlarged oxetanocin A analogue as an inhibitor of HIV infectivity.
Journal of medicinal chemistry 1991;34(1):343-9.
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1991: Copp R R; Marquez V E
Synthesis of two cyclopentenyl-3-deazapyrimidine carbocyclic nucleosides related to cytidine and uridine.
Journal of medicinal chemistry 1991;34(1):208-12.
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1990: Masood R; Ahluwalia G S; Cooney D A; Fridland A; Marquez V E; Driscoll J S; Hao Z; Mitsuya H; Perno C F; Broder S
2'-Fluoro-2',3'-dideoxyarabinosyladenine: a metabolically stable analogue of the antiretroviral agent 2',3'-dideoxyadenosine.
Molecular pharmacology 1990;37(4):590-6.
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1990: Goldstein B M; Bell J E; Marquez V E
Dehydrogenase binding by tiazofurin anabolites.
Journal of medicinal chemistry 1990;33(4):1123-7.
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1990: Marquez V E; Tseng C K; Mitsuya H; Aoki S; Kelley J A; Ford H; Roth J S; Broder S; Johns D G; Driscoll J S
Acid-stable 2'-fluoro purine dideoxynucleosides as active agents against HIV.
Journal of medicinal chemistry 1990;33(3):978-85.
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1990: Marquez V E
Effect of fluorine substitution on the anti-HIV activity of dideoxynucleosides.
NIDA research monograph 1990;96():61-79.
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1990: Marquez V E; Bodenteich M; Copp R R; Lim B B
Synthesis and biological activity of novel carbocyclic nucleosides.
Nucleic acids symposium series 1990;(22):35-6.
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1990: Fridland A; Johnson M A; Cooney D A; Ahluwalia G; Marquez V E; Driscoll J S; Johns D G
Metabolism in human leukocytes of anti-HIV dideoxypurine nucleosides.
Annals of the New York Academy of Sciences 1990;616():205-16.
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1989: Tseng C K; Marquez V E; Fuller R W; Goldstein B M; Haines D R; McPherson H; Parsons J L; Shannon W M; Arnett G; Hollingshead M
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.
Journal of medicinal chemistry 1989;32(7):1442-6.
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1989: Kang G J; Cooney D A; Moyer J D; Kelley J A; Kim H Y; Marquez V E; Johns D G
Cyclopentenylcytosine triphosphate. Formation and inhibition of CTP synthetase.
The Journal of biological chemistry 1989;264(2):713-8.
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1988: Marquez V E; Lim M I; Treanor S P; Plowman J; Priest M A; Markovac A; Khan M S; Kaskar B; Driscoll J S
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
Journal of medicinal chemistry 1988;31(9):1687-94.
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1988: Goldstein B M; Mao D T; Marquez V E
Ara-tiazofurin: conservation of structural features in an unusual thiazole nucleoside.
Journal of medicinal chemistry 1988;31(5):1026-31.
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1987: Cooney D; Hamel E; Cohen M; Kang G J; Dalal M; Marquez V
A simple method for the rapid determination of the stereospecificity of NAD-dependent dehydrogenases applied to mammalian IMP dehydrogenase and bacterial NADH peroxidase.
Biochimica et biophysica acta 1987;916(1):89-93.
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1987: Marquez V E; Tseng C K; Kelley J A; Mitsuya H; Broder S; Roth J S; Driscoll J S
2',3'-Dideoxy-2'-fluoro-ara-A. An acid-stable purine nucleoside active against human immunodeficiency virus (HIV).
Biochemical pharmacology 1987;36(17):2719-22.
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1987: Haines D R; Tseng C K; Marquez V E
Synthesis and biological activity of unsaturated carboacyclic purine nucleoside analogues.
Journal of medicinal chemistry 1987;30(5):943-7.
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1987: Haines D R; Fuller R W; Ahmad S; Vistica D T; Marquez V E
Selective cytotoxicity of a system L specific amino acid nitrogen mustard.
Journal of medicinal chemistry 1987;30(3):542-7.
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1986: Glazer R I; Knode M C; Tseng C K; Haines D R; Marquez V E
3-Deazaneplanocin A: a new inhibitor of S-adenosylhomocysteine synthesis and its effects in human colon carcinoma cells.
Biochemical pharmacology 1986;35(24):4523-7.
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1986: Kelley J A; Driscoll J S; McCormack J J; Roth J S; Marquez V E
Furanose-pyranose isomerization of reduced pyrimidine and cyclic urea ribosides.
Journal of medicinal chemistry 1986;29(11):2351-8.
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1986: Marquez V E; Tseng C K; Gebeyehu G; Cooney D A; Ahluwalia G S; Kelley J A; Dalal M; Fuller R W; Wilson Y A; Johns D G
Thiazole-4-carboxamide adenine dinucleotide (TAD). Analogues stable to phosphodiesterase hydrolysis.
Journal of medicinal chemistry 1986;29(9):1726-31.
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1986: Kim C H; Marquez V E; Mao D T; Haines D R; McCormack J J
Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase.
Journal of medicinal chemistry 1986;29(8):1374-80.
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1986: Moyer J D; Malinowski N M; Treanor S P; Marquez V E
Antitumor activity and biochemical effects of cyclopentenyl cytosine in mice.
Cancer research 1986;46(7):3325-9.
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1986: Glazer R I; Cohen M B; Hartman K D; Knode M C; Lim M I; Marquez V E
Induction of differentiation in the human promyelocytic leukemia cell line HL-60 by the cyclopentenyl analogue of cytidine.
Biochemical pharmacology 1986;35(11):1841-8.
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1986: Glazer R I; Hartman K D; Knode M C; Richard M M; Chiang P K; Tseng C K; Marquez V E
3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.
Biochemical and biophysical research communications 1986;135(2):688-94.
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1986: Marquez V E; Lim M I
Carbocyclic nucleosides.
Medicinal research reviews 1986;6(1):1-40.
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1985: Moyer J D; Karle J M; Malinowski N; Marquez V E; Salam M A; Malspeis L; Cysyk R L
Inhibition of uridine kinase and the salvage of uridine by modified pyrimidine nucleosides.
Molecular pharmacology 1985;28(5):454-60.
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1985: Monks A; Marquez V E; Mao D T; Cysyk R L
Uptake of 2-beta-D-ribofuranosylthiazole-4-carboxamide (tiazofurin) and analogues by the facilitated transport mechanism of erythrocytes.
Cancer letters 1985;28(1):1-8.
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1985: Glazer R I; Knode M C; Lim M I; Marquez V E
Cyclopentenyl cytidine analogue. An inhibitor of cytidine triphosphate synthesis in human colon carcinoma cells.
Biochemical pharmacology 1985;34(14):2535-9.
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1985: Gebeyehu G; Marquez V E; Van Cott A; Cooney D A; Kelley J A; Jayaram H N; Ahluwalia G S; Dion R L; Wilson Y A; Johns D G
Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase.
Journal of medicinal chemistry 1985;28(1):99-105.
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1984: Lim M I; Moyer J D; Cysyk R I; Marquez V E
Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase.
Journal of medicinal chemistry 1984;27(12):1536-8.
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1984: Mao D T; Driscoll J S; Marquez V E
Synthesis of 3-hydroxy-2- and -4-pyridone nucleosides as potential antitumor agents.
Journal of medicinal chemistry 1984;27(2):160-4.
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1983: Jayaram H N; Ahluwalia G S; Dion R L; Gebeyehu G; Marquez V E; Kelley J A; Robins R K; Cooney D A; Johns D G
Conversion of 2-beta-D-ribofuranosylselenazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.
Biochemical pharmacology 1983;32(17):2633-6.
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1983: Gebeyehu G; Marquez V E; Kelley J A; Cooney D A; Jayaram H N; Johns D G
Synthesis of thiazole-4-carboxamide adenine dinucleotide. A powerful inhibitor of IMP dehydrogenase.
Journal of medicinal chemistry 1983;26(6):922-5.
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1983: Cooney D A; Jayaram H N; Glazer R I; Kelley J A; Marquez V E; Gebeyehu G; Van Cott A C; Zwelling L A; Johns D G
Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity.
Advances in enzyme regulation 1983;21():271-303.
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1982: Cooney D A; Jayaram H N; Gebeyehu G; Betts C R; Kelley J A; Marquez V E; Johns D G
The conversion of 2-beta-D-ribofuranosylthiazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.
Biochemical pharmacology 1982;31(11):2133-6.
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1981: Liu P S; Marquez V E; Driscoll J S; Fuller R W; McCormack J J
Cyclic urea nucleosides. Cytidine deaminase activity as a function of aglycon ring size.
Journal of medicinal chemistry 1981;24(6):662-6.
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1980: Marquez V E; Liu P S; Kelley J A; Driscoll J S; McCormack J J
Synthesis of 1,3-diazepin-2-one nucleosides as transition-state inhibitors of cytidine deaminase.
Journal of medicinal chemistry 1980;23(7):713-5.
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