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Susan Marqusee

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TOP 3
Bharat Jagannathan; Carlos Bustamante; Phillip J Elms; Susan Marqusee
Direct observation of a force-induced switch in the anisotropic mechanical unfolding pathway of a protein.
Phillip J Elms; Carlos J Bustamante; John D Chodera; Susan Marqusee
Limitations of constant-force-feedback experiments.
Phillip J Elms; Carlos Bustamante; John D Chodera; Susan Marqusee
The molten globule state is unusually deformable under mechanical force.

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All Publications

2012: Bharat Jagannathan; Carlos Bustamante; Phillip J Elms; Susan Marqusee
Direct observation of a force-induced switch in the anisotropic mechanical unfolding pathway of a protein.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(44):17820-5.
2012: Phillip J Elms; Carlos J Bustamante; John D Chodera; Susan Marqusee
Limitations of constant-force-feedback experiments.
Biophysical journal 2012;103(7):1490-9.
2012: Phillip J Elms; Carlos Bustamante; John D Chodera; Susan Marqusee
The molten globule state is unusually deformable under mechanical force.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(10):3796-801.
2011: Katherine H Miller; Susan Marqusee
Propensity for C-terminal domain swapping correlates with increased regional flexibility in the C-terminus of RNase A.
Protein science : a publication of the Protein Society 2011;20(10):1735-44.
2011: Rachel Bernstein; Pehr B Harbury; Kierstin L Schmidt; Susan Marqusee
Structural and kinetic mapping of side-chain exposure onto the protein energy landscape.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(26):10532-7.
2010: Melinda S Hanes; Kathleen Ratcliff; Susan Marqusee; Tracy M Handel
Protein-protein binding affinities by pulse proteolysis: application to TEM-1/BLIP protein complexes.
Protein science : a publication of the Protein Society 2010;19(10):1996-2000.
2010: Katherine H Miller; Jessica R Karr; Susan Marqusee
A hinge region cis-proline in ribonuclease A acts as a conformational gatekeeper for C-terminal domain swapping.
Journal of molecular biology 2010;400(3):567-78.
2010: Elizabeth A Shank; Ciro Cecconi; Jesse W Dill; Susan Marqusee; Carlos Bustamante
The folding cooperativity of a protein is controlled by its chain topology.
Nature 2010;465(7298):637-40.
2009: Katelyn B Connell; Geoffrey A Horner; Susan Marqusee
A single mutation at residue 25 populates the folding intermediate of E. coli RNase H and reveals a highly dynamic partially folded ensemble.
Journal of molecular biology 2009;391(2):461-70.
2009: Katelyn B Connell; Erik Miller; Susan Marqusee
The folding trajectory of RNase H is dominated by its topology and not local stability: a protein engineering study of variants that fold via two-state and three-state mechanisms.
Journal of molecular biology 2009;391(2):450-60.
2009: Kathleen Ratcliff; Jacob Corn; Susan Marqusee
Structure, stability, and folding of ribonuclease H1 from the moderately thermophilic Chlorobium tepidum: comparison with thermophilic and mesophilic homologues.
Biochemistry 2009;48(25):5890-8.
2008: Ciro Cecconi; Elizabeth A Shank; Frederick W Dahlquist; Susan Marqusee; Carlos Bustamante
Protein-DNA chimeras for single molecule mechanical folding studies with the optical tweezers.
European biophysics journal : EBJ 2008;37(6):729-38.
2007: Chiwook Park; Sharleen Zhou; Jacqueline Gilmore; Susan Marqusee
Energetics-based protein profiling on a proteomic scale: identification of proteins resistant to proteolysis.
Journal of molecular biology 2007;368(5):1426-37.
2007: Tracy A Young; Emmanuel Skordalakes; Susan Marqusee
Comparison of proteolytic susceptibility in phosphoglycerate kinases from yeast and E. coli: modulation of conformational ensembles without altering structure or stability.
Journal of molecular biology 2007;368(5):1438-47.
2007: Jason Cellitti; Manuel Llinas; Nathaniel Echols; Elizabeth A Shank; Blake Gillespie; Ester Kwon; Scott M Crowder; Frederick W Dahlquist; Thomas Alber; Susan Marqusee
Exploring subdomain cooperativity in T4 lysozyme I: structural and energetic studies of a circular permutant and protein fragment.
Protein science : a publication of the Protein Society 2007;16(5):842-51.
2007: Jason Cellitti; Rachel Bernstein; Susan Marqusee
Exploring subdomain cooperativity in T4 lysozyme II: uncovering the C-terminal subdomain as a hidden intermediate in the kinetic folding pathway.
Protein science : a publication of the Protein Society 2007;16(5):852-62.
2006: Chiwook Park; Susan Marqusee
Quantitative determination of protein stability and ligand binding by pulse proteolysis.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2006;Chapter 20():Unit 20.11.
2006: Tanya S Freedman; Holger Sondermann; Gregory D Friedland; Tanja Kortemme; Dafna Bar-Sagi; Susan Marqusee; John Kuriyan
A Ras-induced conformational switch in the Ras activator Son of sevenless.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16692-7.
2006: David Wildes; L Meadow Anderson; Alex Sabogal; Susan Marqusee
Native state energetics of the Src SH2 domain: evidence for a partially structured state in the denatured ensemble.
Protein science : a publication of the Protein Society 2006;15(7):1769-79.
2006: Miguel A de Los Rios; BK Muralidhara; David Wildes; Tobin R Sosnick; Susan Marqusee; Pernilla Wittung-Stafshede; Kevin W Plaxco; Ingo Ruczinski
On the precision of experimentally determined protein folding rates and phi-values.
Protein science : a publication of the Protein Society 2006;15(3):553-63.
2005: Ciro Cecconi; Elizabeth A Shank; Carlos Bustamante; Susan Marqusee
Direct observation of the three-state folding of a single protein molecule.
Science (New York, N.Y.) 2005;309(5743):2057-60.
2005: Chiwook Park; Susan Marqusee
Pulse proteolysis: a simple method for quantitative determination of protein stability and ligand binding.
Nature methods 2005;2(3):207-12.
2005: David Wildes; Susan Marqusee
Hydrogen exchange and ligand binding: ligand-dependent and ligand-independent protection in the Src SH3 domain.
Protein science : a publication of the Protein Society 2005;14(1):81-8.
2004: Chiwook Park; Susan Marqusee
Probing the high energy states in proteins by proteolysis.
Journal of molecular biology 2004;343(5):1467-76.
2004: Chiwook Park; Susan Marqusee
Analysis of the stability of multimeric proteins by effective DeltaG and effective m-values.
Protein science : a publication of the Protein Society 2004;13(9):2553-8.
2004: Giulietta M Spudich; Erik Miller; Susan Marqusee
Destabilization of the Escherichia coli RNase H kinetic intermediate: switching between a two-state and three-state folding mechanism.
Journal of molecular biology 2004;335(2):609-18.
2004: David Wildes; Susan Marqusee
Hydrogen-exchange strategies applied to energetics of intermediate processes in protein folding.
Methods in enzymology 2004;380():328-49.
2003: Srebrenka Robic; Mercedes Guzman-Casado; Jose M Sanchez-Ruiz; Susan Marqusee
Role of residual structure in the unfolded state of a thermophilic protein.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11345-9.
2003: Rosalind Kim; Luhua Lai; Hi-Hong Lee; Gang-Won Cheong; Kyeong Kyu Kim; Zheng Wu; Hisao Yokota; Susan Marqusee; Sung-Huo S H Kim
On the mechanism of chaperone activity of the small heat-shock protein of Methanococcus jannaschii.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8151-5.
2003: Mercedes Guzman-Casado; Antonio Parody-Morreale; Srebrenka Robic; Susan Marqusee; Jose M Sanchez-Ruiz
Energetic evidence for formation of a pH-dependent hydrophobic cluster in the denatured state of Thermus thermophilus ribonuclease H.
Journal of molecular biology 2003;329(4):731-43.
2002: Erik Miller; Kael F Fischer; Susan Marqusee
Experimental evaluation of topological parameters determining protein-folding rates.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10359-63.
2002: Gunther Kern; Jeffrey G Pelton; Susan Marqusee; Dorothee Kern
Structural properties of the histidine-containing loop in HIV-1 RNase H.
Biophysical chemistry 2002;96(2-3):285-91.
2002: Giulietta M Spudich; Sonja Lorenz; Susan Marqusee
Propagation of a single destabilizing mutation throughout the Escherichia coli ribonuclease HI native state.
Protein science : a publication of the Protein Society 2002;11(3):522-8.
2002: Eric M Nicholson; Huaping Mo; Stanley B Prusiner; Fred Cohen; Susan Marqusee
Differences between the prion protein and its homolog Doppel: a partially structured state with implications for scrapie formation.
Journal of molecular biology 2002;316(3):807-15.
2002: Julie Hollien; Susan Marqusee
Comparison of the folding processes of T. thermophilus and E. coli ribonucleases H.
Journal of molecular biology 2002;316(2):327-40.
2002: Srebrenka Robic; James M Berger; Susan Marqusee
Contributions of folding cores to the thermostabilities of two ribonucleases H.
Protein science : a publication of the Protein Society 2002;11(2):381-9.
2001: Eric R Goedken; Susan Marqusee
Native-state energetics of a thermostabilized variant of ribonuclease HI.
Journal of molecular biology 2001;314(4):863-71.
2001: Eric R Goedken; Susan Marqusee
Co-crystal of Escherichia coli RNase HI with Mn2+ ions reveals two divalent metals bound in the active site.
The Journal of biological chemistry 2001;276(10):7266-71.
2001: MJ Parker; Susan Marqusee
A kinetic folding intermediate probed by native state hydrogen exchange.
Journal of molecular biology 2001;305(3):593-602.
2000: Eric R Goedken; James L Keck; James M Berger; Susan Marqusee
Divalent metal cofactor binding in the kinetic folding trajectory of Escherichia coli ribonuclease HI.
Protein science : a publication of the Protein Society 2000;9(10):1914-21.
2000: Giulietta M Spudich; Susan Marqusee
A change in the apparent m value reveals a populated intermediate under equilibrium conditions in Escherichia coli ribonuclease HI.
Biochemistry 2000;39(38):11677-83.
2000: Kael F Fischer; Susan Marqusee
A rapid test for identification of autonomous folding units in proteins.
Journal of molecular biology 2000;302(3):701-12.
2000: Eric A Toth; Carolyn A Worby; Jack E Dixon; Eric R Goedken; Susan Marqusee; Todd O Yeates
The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
Journal of molecular biology 2000;301(2):433-50.
2000: MJ Parker; Susan Marqusee
A statistical appraisal of native state hydrogen exchange data: evidence for a burst phase continuum?
Journal of molecular biology 2000;300(5):1361-75.
2000: A K Chamberlain; Susan Marqusee
Comparison of equilibrium and kinetic approaches for determining protein folding mechanisms.
Advances in protein chemistry 2000;53():283-328.
1999: Julie Hollien; Susan Marqusee
Structural distribution of stability in a thermophilic enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):13674-8.
1999: MJ Parker; Susan Marqusee
The cooperativity of burst phase reactions explored.
Journal of molecular biology 1999;293(5):1195-210.
1999: Eric R Goedken; Susan Marqusee
Metal binding and activation of the ribonuclease H domain from moloney murine leukemia virus.
Protein engineering 1999;12(11):975-80.
1999: M Llinás; B Gillespie; Frederick W Dahlquist; Susan Marqusee
The energetics of T4 lysozyme reveal a hierarchy of conformations.
Nature structural biology 1999;6(11):1072-8.
1999: TM Raschke; J Kho; Susan Marqusee
Confirmation of the hierarchical folding of RNase H: a protein engineering study.
Nature structural biology 1999;6(9):825-31.
1999: H Liu; Shauna Farr-Jones; Nikolai B Ulyanov; M Llinas; Susan Marqusee; Darlene Groth; Fred Cohen; Stanley B Prusiner; Tom L James
Solution structure of Syrian hamster prion protein rPrP(90-231).
Biochemistry 1999;38(17):5362-77.
1999: Julie Hollien; Susan Marqusee
A thermodynamic comparison of mesophilic and thermophilic ribonucleases H.
Biochemistry 1999;38(12):3831-6.
1998: James L Keck; Eric R Goedken; Susan Marqusee
Activation/attenuation model for RNase H. A one-metal mechanism with second-metal inhibition.
The Journal of biological chemistry 1998;273(51):34128-33.
1998: Gunther Kern; Tracy M Handel; Susan Marqusee
Characterization of a folding intermediate from HIV-1 ribonuclease H.
Protein science : a publication of the Protein Society 1998;7(10):2164-74.
1998: Eric R Goedken; Susan Marqusee
Folding the ribonuclease H domain of Moloney murine leukemia virus reverse transcriptase requires metal binding or a short N-terminal extension.
Proteins 1998;33(1):135-43.
1998: AK Chamberlain; Susan Marqusee
Molten globule unfolding monitored by hydrogen exchange in urea.
Biochemistry 1998;37(7):1736-42.
1998: TM Raschke; Susan Marqusee
Hydrogen exchange studies of protein structure.
Current opinion in biotechnology 1998;9(1):80-6.
1998: M Llinás; Susan Marqusee
Subdomain interactions as a determinant in the folding and stability of T4 lysozyme.
Protein science : a publication of the Protein Society 1998;7(1):96-104.
1997: AK Chamberlain; Susan Marqusee
Touring the landscapes: partially folded proteins examined by hydrogen exchange.
Structure (London, England : 1993) 1997;5(7):859-63.
1997: Eric R Goedken; TM Raschke; Susan Marqusee
Importance of the C-terminal helix to the stability and enzymatic activity of Escherichia coli ribonuclease H.
Biochemistry 1997;36(23):7256-63.
1997: TM Raschke; Susan Marqusee
The kinetic folding intermediate of ribonuclease H resembles the acid molten globule and partially unfolded molecules detected under native conditions.
Nature structural biology 1997;4(4):298-304.
1996: J M Dabora; Jeffrey G Pelton; Susan Marqusee
Structure of the acid state of Escherichia coli ribonuclease HI.
Biochemistry 1996;35(37):11951-8.
1996: A K Chamberlain; Tracy M Handel; Susan Marqusee
Detection of rare partially folded molecules in equilibrium with the native conformation of RNaseH.
Nature structural biology 1996;3(9):782-7.
1996: James L Keck; Susan Marqusee
The putative substrate recognition loop of Escherichia coli ribonuclease H is not essential for activity.
The Journal of biological chemistry 1996;271(33):19883-7.
1995: James L Keck; Susan Marqusee
Substitution of a highly basic helix/loop sequence into the RNase H domain of human immunodeficiency virus reverse transcriptase restores its Mn(2+)-dependent RNase H activity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2740-4.
1994: Susan Marqusee; Robert T Sauer
Contributions of a hydrogen bond/salt bridge network to the stability of secondary and tertiary structure in lambda repressor.
Protein science : a publication of the Protein Society 1994;3(12):2217-25.
1994: J M Dabora; Susan Marqusee
Equilibrium unfolding of Escherichia coli ribonuclease H: characterization of a partially folded state.
Protein science : a publication of the Protein Society 1994;3(9):1401-8.
1991: Susan Marqusee; L Regan
Deconstructing protein structure.
Current biology : CB 1991;1(4):207-8.
1991: J Martin Scholtz; Susan Marqusee; Robert L Baldwin; E J York; J M Stewart; M Santoro; David Bolen
Calorimetric determination of the enthalpy change for the alpha-helix to coil transition of an alanine peptide in water.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2854-8.
1990: S Padmanabhan; Susan Marqusee; T Ridgeway; T M Laue; Robert L Baldwin
Relative helix-forming tendencies of nonpolar amino acids.
Nature 1990;344(6263):268-70.
1989: Susan Marqusee; V H Robbins; Robert L Baldwin
Unusually stable helix formation in short alanine-based peptides.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5286-90.
1987: Susan Marqusee; Robert L Baldwin
Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8898-902.
1985: K R Shoemaker; P S Kim; D N Brems; Susan Marqusee; E J York; I M Chaiken; J M Stewart; Robert L Baldwin
Nature of the charged-group effect on the stability of the C-peptide helix.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(8):2349-53.